FHIT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.86641466
2L-phenylalanine catabolic process (GO:0006559)5.86641466
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.39406850
4L-phenylalanine metabolic process (GO:0006558)5.39406850
5activated T cell proliferation (GO:0050798)4.35735573
6aromatic amino acid family catabolic process (GO:0009074)4.22288324
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05767380
8autophagic vacuole fusion (GO:0000046)4.02334841
9xenobiotic catabolic process (GO:0042178)4.02091674
10response to nitrosative stress (GO:0051409)3.91150704
11DNA deamination (GO:0045006)3.87500094
12protein polyglutamylation (GO:0018095)3.79051785
13coenzyme catabolic process (GO:0009109)3.79037407
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77817950
15signal peptide processing (GO:0006465)3.73783132
16dopamine transport (GO:0015872)3.71214937
17cofactor catabolic process (GO:0051187)3.65515467
18purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.63558463
193-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.63558463
20positive regulation of granulocyte differentiation (GO:0030854)3.61658208
21organelle membrane fusion (GO:0090174)3.58737470
22fatty acid elongation (GO:0030497)3.57365255
23negative T cell selection (GO:0043383)3.46481912
24ubiquinone biosynthetic process (GO:0006744)3.45671081
25protein complex biogenesis (GO:0070271)3.31636651
26regulation of type B pancreatic cell apoptotic process (GO:2000674)3.30633848
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29847272
28positive T cell selection (GO:0043368)3.29085800
29positive regulation of gamma-delta T cell activation (GO:0046645)3.28436551
30bile acid biosynthetic process (GO:0006699)3.27600327
31tyrosine metabolic process (GO:0006570)3.27090707
32negative thymic T cell selection (GO:0045060)3.25930018
33regulation of B cell receptor signaling pathway (GO:0050855)3.25632724
34positive regulation of cellular amine metabolic process (GO:0033240)3.23692420
35alkaloid metabolic process (GO:0009820)3.19019790
36glutathione derivative biosynthetic process (GO:1901687)3.18123913
37glutathione derivative metabolic process (GO:1901685)3.18123913
38behavioral response to nicotine (GO:0035095)3.18061760
39nucleotide transmembrane transport (GO:1901679)3.18019181
40respiratory electron transport chain (GO:0022904)3.17151455
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16978497
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.16978497
43NADH dehydrogenase complex assembly (GO:0010257)3.16978497
44energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16520357
45ATP synthesis coupled proton transport (GO:0015986)3.16520357
46neuron fate specification (GO:0048665)3.14792301
47aromatic amino acid family metabolic process (GO:0009072)3.11806344
48electron transport chain (GO:0022900)3.10780684
49respiratory chain complex IV assembly (GO:0008535)3.07453375
50drug transmembrane transport (GO:0006855)3.07093756
51mast cell activation (GO:0045576)3.03828993
52mast cell activation involved in immune response (GO:0002279)3.03552777
53mast cell degranulation (GO:0043303)3.03552777
54glyoxylate metabolic process (GO:0046487)3.02298905
55negative regulation of cell killing (GO:0031342)3.02142254
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02142254
57benzene-containing compound metabolic process (GO:0042537)2.99596801
58purine deoxyribonucleotide catabolic process (GO:0009155)2.98837884
59ribosomal small subunit assembly (GO:0000028)2.98446328
60fucose catabolic process (GO:0019317)2.97787760
61L-fucose metabolic process (GO:0042354)2.97787760
62L-fucose catabolic process (GO:0042355)2.97787760
63ubiquinone metabolic process (GO:0006743)2.97416716
64regulation of protein glycosylation (GO:0060049)2.96397247
65regulation of cholesterol biosynthetic process (GO:0045540)2.94893384
66regulation of cholesterol esterification (GO:0010872)2.94723086
67cellular response to interferon-beta (GO:0035458)2.94011855
68response to dietary excess (GO:0002021)2.93999137
69response to interferon-beta (GO:0035456)2.93629975
70positive regulation of T cell differentiation in thymus (GO:0033089)2.93047651
71GPI anchor biosynthetic process (GO:0006506)2.91827456
72mitochondrial respiratory chain complex assembly (GO:0033108)2.90636414
73very long-chain fatty acid metabolic process (GO:0000038)2.89396396
74tryptophan metabolic process (GO:0006568)2.89108163
75peroxisome fission (GO:0016559)2.87983074
76cellular glucuronidation (GO:0052695)2.87568800
77positive thymic T cell selection (GO:0045059)2.87236146
78bile acid metabolic process (GO:0008206)2.86503952
79glutathione metabolic process (GO:0006749)2.85957842
80indole-containing compound catabolic process (GO:0042436)2.85922386
81indolalkylamine catabolic process (GO:0046218)2.85922386
82tryptophan catabolic process (GO:0006569)2.85922386
83catecholamine transport (GO:0051937)2.84417056
84G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.83475952
85cranial nerve development (GO:0021545)2.81037791
86antigen processing and presentation of endogenous antigen (GO:0019883)2.79247657
87opsonization (GO:0008228)2.79193443
88endocrine pancreas development (GO:0031018)2.78880485
89drug catabolic process (GO:0042737)2.78548470
90peripheral nervous system neuron development (GO:0048935)2.77999663
91ketone body metabolic process (GO:1902224)2.77525409
92GPI anchor metabolic process (GO:0006505)2.76334801
93phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.76179262
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75504484
95polyol transport (GO:0015791)2.74420252
96cellular ketone body metabolic process (GO:0046950)2.73474597
97ER overload response (GO:0006983)2.73342499
98glucuronate metabolic process (GO:0019585)2.72946497
99uronic acid metabolic process (GO:0006063)2.72946497
100mannosylation (GO:0097502)2.72603447
101ribonucleoside bisphosphate metabolic process (GO:0033875)2.72530754
102nucleoside bisphosphate metabolic process (GO:0033865)2.72530754
103purine nucleoside bisphosphate metabolic process (GO:0034032)2.72530754
104interferon-gamma production (GO:0032609)2.72291364
105quinone biosynthetic process (GO:1901663)2.71978321
106response to pheromone (GO:0019236)2.71654316
107exogenous drug catabolic process (GO:0042738)2.71348362
108cellular response to interleukin-15 (GO:0071350)2.71194319
109omega-hydroxylase P450 pathway (GO:0097267)2.70967082
110regulation of dopamine metabolic process (GO:0042053)2.69801409
111regulation of catecholamine metabolic process (GO:0042069)2.69801409
112amine catabolic process (GO:0009310)2.69758042
113cellular biogenic amine catabolic process (GO:0042402)2.69758042
114high-density lipoprotein particle remodeling (GO:0034375)2.68286781
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67511612
116indolalkylamine metabolic process (GO:0006586)2.67102387
117negative regulation of phagocytosis (GO:0050765)2.65875055
118drug transport (GO:0015893)2.64429272
119CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.64347175
120short-chain fatty acid metabolic process (GO:0046459)2.64213147
121regulation of gamma-delta T cell differentiation (GO:0045586)2.64195535
122toxin metabolic process (GO:0009404)2.63622428
123negative regulation of lipase activity (GO:0060192)2.62712553
124regulation of T cell receptor signaling pathway (GO:0050856)2.61183053
125branched-chain amino acid catabolic process (GO:0009083)2.60871088
126regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.60061404
127T cell selection (GO:0045058)2.57810739
128regulation of regulatory T cell differentiation (GO:0045589)2.57774320
129deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.56855292
130positive regulation of prostaglandin secretion (GO:0032308)2.56367255
131imidazole-containing compound metabolic process (GO:0052803)2.55263243
132water-soluble vitamin biosynthetic process (GO:0042364)2.55025694
133negative regulation of execution phase of apoptosis (GO:1900118)2.52969082
134central nervous system myelination (GO:0022010)2.52710625
135axon ensheathment in central nervous system (GO:0032291)2.52710625
136adenosine metabolic process (GO:0046085)2.52461007
137valine metabolic process (GO:0006573)2.52358805
138monoamine transport (GO:0015844)2.52328636
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52287741
140regulation of cholesterol metabolic process (GO:0090181)2.51682288
141axoneme assembly (GO:0035082)2.51584880
142cytochrome complex assembly (GO:0017004)2.51186062
143cholesterol biosynthetic process (GO:0006695)2.50708774
144response to interleukin-15 (GO:0070672)2.48878889
145regulation of fibrinolysis (GO:0051917)2.47301702
146intestinal cholesterol absorption (GO:0030299)2.46959090
147purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.46513738
148positive regulation of insulin secretion (GO:0032024)2.45824247
149piRNA metabolic process (GO:0034587)2.45496917
150preassembly of GPI anchor in ER membrane (GO:0016254)2.44080302
151positive regulation of T cell mediated cytotoxicity (GO:0001916)2.43700466
152alpha-amino acid catabolic process (GO:1901606)2.43620698
153regulation of cilium movement (GO:0003352)2.43449190
154regulation of gamma-delta T cell activation (GO:0046643)2.43366170
155antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43289323
156negative regulation of telomere maintenance (GO:0032205)2.42344854
157triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.41716381
158regulation of oxidative phosphorylation (GO:0002082)2.41613713
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.40580771
160platelet dense granule organization (GO:0060155)2.40413440
161regulation of thymocyte apoptotic process (GO:0070243)2.39438016
162positive regulation of defense response to virus by host (GO:0002230)2.37898900
163negative regulation of mast cell activation (GO:0033004)2.37455106
164immunoglobulin mediated immune response (GO:0016064)2.37221109
165tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.35921241
166RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.35921241
167seminiferous tubule development (GO:0072520)2.35879611
168T cell migration (GO:0072678)2.35605247
169phosphatidylinositol acyl-chain remodeling (GO:0036149)2.35449913
170negative regulation of thymocyte apoptotic process (GO:0070244)2.35289839
171peptidyl-histidine modification (GO:0018202)2.34857209
172positive regulation of B cell differentiation (GO:0045579)2.34483494
173negative regulation of T cell mediated immunity (GO:0002710)2.34210720
174tolerance induction (GO:0002507)2.34205517
175deoxyribonucleotide catabolic process (GO:0009264)2.33014289
176purinergic nucleotide receptor signaling pathway (GO:0035590)2.31159938
177regulation of T cell mediated cytotoxicity (GO:0001914)2.30845587
178leukocyte degranulation (GO:0043299)2.27833314
179negative regulation of B cell apoptotic process (GO:0002903)2.27626483
180DNA methylation involved in gamete generation (GO:0043046)2.26434453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.46920478
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.25927247
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.49553187
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23097528
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.18891176
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.17853385
7ZNF274_21170338_ChIP-Seq_K562_Hela2.92884809
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.92411620
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.83513933
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.80167605
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55614407
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.50007662
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.45400467
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40562249
15TAF15_26573619_Chip-Seq_HEK293_Human2.37513748
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35626631
17* GBX2_23144817_ChIP-Seq_PC3_Human2.33689956
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.27323759
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24597553
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.16382331
21RUNX_20019798_ChIP-Seq_JUKART_Human2.09920582
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.08123929
23VDR_23849224_ChIP-Seq_CD4+_Human2.04625393
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03611089
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00923139
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95959444
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.94262313
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88980818
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87515768
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84712763
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.83474298
32GATA3_26560356_Chip-Seq_TH2_Human1.79575618
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78293376
34MYB_26560356_Chip-Seq_TH2_Human1.78201486
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69410919
36FOXP3_21729870_ChIP-Seq_TREG_Human1.66003314
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63257554
38GATA3_27048872_Chip-Seq_THYMUS_Human1.62822674
39VDR_22108803_ChIP-Seq_LS180_Human1.62770837
40* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61789101
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.59386624
42* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57195343
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54103209
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52178190
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50789327
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48560351
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.47946641
48TP53_22573176_ChIP-Seq_HFKS_Human1.47806131
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47438149
50* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42433115
51CIITA_25753668_ChIP-Seq_RAJI_Human1.41350155
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39579239
53MYB_26560356_Chip-Seq_TH1_Human1.38133357
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37372081
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37299252
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37044760
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36868544
58IRF1_19129219_ChIP-ChIP_H3396_Human1.35707242
59ERG_20517297_ChIP-Seq_VCAP_Human1.35028402
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33967935
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.32413198
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31666818
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.30963968
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.30756169
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30121096
66ER_23166858_ChIP-Seq_MCF-7_Human1.29849130
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.29578352
68MYC_18940864_ChIP-ChIP_HL60_Human1.29415100
69P300_19829295_ChIP-Seq_ESCs_Human1.28595606
70EZH2_22144423_ChIP-Seq_EOC_Human1.27973541
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25483320
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24693861
73* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24370656
74* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23359142
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22956030
76* PIAS1_25552417_ChIP-Seq_VCAP_Human1.22536301
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.21616314
78SCL_19346495_ChIP-Seq_HPC-7_Human1.21383204
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21260877
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20881166
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20532007
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.20203878
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20203878
84* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20125985
85* AR_20517297_ChIP-Seq_VCAP_Human1.18446478
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18216724
87* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17238606
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15137607
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14911972
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.14585496
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.14438593
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13946106
93EWS_26573619_Chip-Seq_HEK293_Human1.13872035
94TAF2_19829295_ChIP-Seq_ESCs_Human1.13239177
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.11540062
96* CBP_20019798_ChIP-Seq_JUKART_Human1.11412422
97* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11412422
98RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10217169
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.09852856
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09808481
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08784504
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08592976
103RNF2_27304074_Chip-Seq_NSC_Mouse1.08533025
104NANOG_20526341_ChIP-Seq_ESCs_Human1.08346633
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07690239
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07251709
107* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06470338
108MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06234107
109P53_22387025_ChIP-Seq_ESCs_Mouse1.06170831
110KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06035502
111TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05890591
112GATA1_22025678_ChIP-Seq_K562_Human1.05560526
113* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05432654
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05255008
115ELK1_19687146_ChIP-ChIP_HELA_Human1.04681957
116SPI1_23547873_ChIP-Seq_NB4_Human1.04355717
117JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04315409
118ERA_21632823_ChIP-Seq_H3396_Human1.04302122
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04053741
120* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03934945
121GATA3_26560356_Chip-Seq_TH1_Human1.03795687
122FUS_26573619_Chip-Seq_HEK293_Human1.03607766
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03541952
124SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03412038
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02808439
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02304601
127EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01908224
128RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01132568
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00892202
130BCAT_22108803_ChIP-Seq_LS180_Human1.00798135
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.00594407
132NMYC_18555785_Chip-Seq_ESCs_Mouse1.00317455
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99819465
134SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99782069
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99056909
136SOX2_20726797_ChIP-Seq_SW620_Human0.98626508
137P300_18555785_Chip-Seq_ESCs_Mouse0.98205947
138NFE2_27457419_Chip-Seq_LIVER_Mouse0.97961196
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.97099001
140CMYC_18555785_Chip-Seq_ESCs_Mouse0.96648112
141* SMAD4_21799915_ChIP-Seq_A2780_Human0.96136557
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95794026
143* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95791979
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95474806
145* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95183589
146BCL6_27268052_Chip-Seq_Bcells_Human0.94768846
147RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94499894
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94061228
149GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93903910
150NANOG_19829295_ChIP-Seq_ESCs_Human0.93731246
151SOX2_19829295_ChIP-Seq_ESCs_Human0.93731246
152FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93693324
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93557641
154SOX2_18555785_Chip-Seq_ESCs_Mouse0.92334457
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.91254793
156IGF1R_20145208_ChIP-Seq_DFB_Human0.90990775
157PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90566544
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.89807181
159FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89801697
160DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89706622
161NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89604692
162NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89604692
163KLF4_18555785_Chip-Seq_ESCs_Mouse0.89443795
164REST_21632747_ChIP-Seq_MESCs_Mouse0.89130006
165CRX_20693478_ChIP-Seq_RETINA_Mouse0.88556890
166OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88302044
167TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88031241
168TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87922574
169FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87410437
170EGR1_19032775_ChIP-ChIP_M12_Human0.87356163
171AR_21572438_ChIP-Seq_LNCaP_Human0.87242183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.29464908
2MP0008875_abnormal_xenobiotic_pharmacok3.74467390
3MP0005365_abnormal_bile_salt3.55526952
4MP0005085_abnormal_gallbladder_physiolo3.21077904
5MP0005671_abnormal_response_to2.65973327
6MP0005360_urolithiasis2.64468307
7MP0003195_calcinosis2.62196883
8MP0008877_abnormal_DNA_methylation2.50738016
9MP0001905_abnormal_dopamine_level2.46108135
10MP0005379_endocrine/exocrine_gland_phen2.42751440
11MP0006276_abnormal_autonomic_nervous2.38897248
12MP0003646_muscle_fatigue2.38763848
13MP0002132_abnormal_respiratory_system2.36948051
14MP0003806_abnormal_nucleotide_metabolis2.32025409
15MP0004043_abnormal_pH_regulation2.28937735
16MP0003763_abnormal_thymus_physiology2.26789313
17MP0001986_abnormal_taste_sensitivity2.19858127
18MP0001835_abnormal_antigen_presentation2.10645978
19MP0001800_abnormal_humoral_immune2.02073452
20MP0003724_increased_susceptibility_to1.98193711
21MP0002822_catalepsy1.94355594
22MP0008789_abnormal_olfactory_epithelium1.90296416
23MP0009379_abnormal_foot_pigmentation1.89127548
24MP0004270_analgesia1.83343764
25MP0005670_abnormal_white_adipose1.82429800
26MP0005000_abnormal_immune_tolerance1.79991776
27MP0002876_abnormal_thyroid_physiology1.79308696
28MP0005332_abnormal_amino_acid1.79009776
29MP0002723_abnormal_immune_serum1.77848861
30MP0005220_abnormal_exocrine_pancreas1.77103662
31MP0003011_delayed_dark_adaptation1.75290859
32MP0000566_synostosis1.75186293
33MP0001666_abnormal_nutrient_absorption1.74879272
34MP0010386_abnormal_urinary_bladder1.72595749
35MP0002148_abnormal_hypersensitivity_rea1.72093867
36MP0001188_hyperpigmentation1.71084564
37MP0001529_abnormal_vocalization1.66860441
38MP0002420_abnormal_adaptive_immunity1.66597569
39MP0005551_abnormal_eye_electrophysiolog1.64920122
40MP0003787_abnormal_imprinting1.64886168
41MP0001819_abnormal_immune_cell1.63433576
42MP0000685_abnormal_immune_system1.62609238
43MP0002735_abnormal_chemical_nociception1.62230962
44MP0002452_abnormal_antigen_presenting1.62154555
45MP0006082_CNS_inflammation1.60380903
46* MP0005025_abnormal_response_to1.59200055
47MP0005408_hypopigmentation1.58872992
48MP0006292_abnormal_olfactory_placode1.54599865
49MP0002419_abnormal_innate_immunity1.54559582
50MP0009785_altered_susceptibility_to1.53934948
51MP0000372_irregular_coat_pigmentation1.53171825
52MP0001502_abnormal_circadian_rhythm1.51792340
53MP0005499_abnormal_olfactory_system1.51254625
54MP0005394_taste/olfaction_phenotype1.51254625
55MP0009697_abnormal_copulation1.50288512
56MP0003186_abnormal_redox_activity1.50036776
57MP0001545_abnormal_hematopoietic_system1.49369847
58MP0005397_hematopoietic_system_phenotyp1.49369847
59MP0005409_darkened_coat_color1.48650968
60MP0002163_abnormal_gland_morphology1.47934570
61MP0005387_immune_system_phenotype1.46552854
62MP0001790_abnormal_immune_system1.46552854
63MP0004142_abnormal_muscle_tone1.41970964
64MP0003252_abnormal_bile_duct1.41388796
65MP0005645_abnormal_hypothalamus_physiol1.41166106
66MP0002398_abnormal_bone_marrow1.41159247
67MP0004381_abnormal_hair_follicle1.38054524
68MP0003436_decreased_susceptibility_to1.35700453
69MP0000689_abnormal_spleen_morphology1.34905119
70MP0002638_abnormal_pupillary_reflex1.34736654
71* MP0000716_abnormal_immune_system1.34068884
72MP0002653_abnormal_ependyma_morphology1.31599441
73MP0001764_abnormal_homeostasis1.29749385
74MP0005253_abnormal_eye_physiology1.29112427
75MP0010329_abnormal_lipoprotein_level1.28829359
76MP0003868_abnormal_feces_composition1.28828068
77MP0002693_abnormal_pancreas_physiology1.27724339
78MP0001944_abnormal_pancreas_morphology1.23074277
79MP0005646_abnormal_pituitary_gland1.23057378
80MP0003718_maternal_effect1.22755243
81MP0003880_abnormal_central_pattern1.21081404
82MP0000703_abnormal_thymus_morphology1.20582268
83MP0001984_abnormal_olfaction1.20076900
84MP0003183_abnormal_peptide_metabolism1.18783764
85MP0002722_abnormal_immune_system1.17095745
86MP0004782_abnormal_surfactant_physiolog1.16917367
87MP0000538_abnormal_urinary_bladder1.16708532
88MP0009333_abnormal_splenocyte_physiolog1.16008098
89MP0003786_premature_aging1.16003919
90MP0005535_abnormal_body_temperature1.14772226
91MP0002102_abnormal_ear_morphology1.14667750
92MP0003136_yellow_coat_color1.14319539
93MP0006035_abnormal_mitochondrial_morpho1.13771833
94MP0005464_abnormal_platelet_physiology1.13371293
95MP0005636_abnormal_mineral_homeostasis1.13209381
96MP0003866_abnormal_defecation1.12549757
97MP0002138_abnormal_hepatobiliary_system1.12322027
98MP0005075_abnormal_melanosome_morpholog1.10498101
99MP0002909_abnormal_adrenal_gland1.10417243
100MP0006036_abnormal_mitochondrial_physio1.10249598
101MP0001501_abnormal_sleep_pattern1.10106012
102MP0009046_muscle_twitch1.09566966
103MP0002933_joint_inflammation1.07048087
104MP0002272_abnormal_nervous_system1.06832001
105MP0006072_abnormal_retinal_apoptosis1.06504132
106MP0002734_abnormal_mechanical_nocicepti1.05382649
107MP0001845_abnormal_inflammatory_respons1.05016191
108MP0005410_abnormal_fertilization1.04899611
109MP0002118_abnormal_lipid_homeostasis1.02568519
110MP0002837_dystrophic_cardiac_calcinosis1.02528919
111* MP0002429_abnormal_blood_cell1.02515241
112MP0005174_abnormal_tail_pigmentation1.01677778
113MP0008872_abnormal_physiological_respon1.00967216
114MP0002557_abnormal_social/conspecific_i1.00890786
115MP0002095_abnormal_skin_pigmentation1.00884943
116MP0004019_abnormal_vitamin_homeostasis1.00465188
117MP0009643_abnormal_urine_homeostasis0.99976643
118MP0002751_abnormal_autonomic_nervous0.99908022
119MP0008058_abnormal_DNA_repair0.99794602
120MP0008469_abnormal_protein_level0.99509548
121MP0009278_abnormal_bone_marrow0.98879322
122MP0004147_increased_porphyrin_level0.97338649
123MP0002928_abnormal_bile_duct0.95908904
124MP0001485_abnormal_pinna_reflex0.95209262
125MP0002277_abnormal_respiratory_mucosa0.94593414
126MP0003656_abnormal_erythrocyte_physiolo0.94399105
127MP0002405_respiratory_system_inflammati0.93961947
128MP0001346_abnormal_lacrimal_gland0.93953731
129MP0000631_abnormal_neuroendocrine_gland0.93928774
130MP0004924_abnormal_behavior0.93469213
131MP0005386_behavior/neurological_phenoty0.93469213
132MP0000678_abnormal_parathyroid_gland0.92192263
133MP0005083_abnormal_biliary_tract0.90866638
134MP0000920_abnormal_myelination0.89631830
135MP0009764_decreased_sensitivity_to0.87742098
136MP0000613_abnormal_salivary_gland0.86738328
137MP0003879_abnormal_hair_cell0.85903935
138MP0005423_abnormal_somatic_nervous0.84916808
139MP0000015_abnormal_ear_pigmentation0.82390758
140MP0010155_abnormal_intestine_physiology0.82132577
141MP0002733_abnormal_thermal_nociception0.81810024
142MP0002078_abnormal_glucose_homeostasis0.81491878
143MP0003690_abnormal_glial_cell0.81478775
144MP0005084_abnormal_gallbladder_morpholo0.79755619
145MP0003953_abnormal_hormone_level0.79411681
146MP0008995_early_reproductive_senescence0.79075541
147MP0001873_stomach_inflammation0.77821887
148MP0005389_reproductive_system_phenotype0.77675691
149MP0001968_abnormal_touch/_nociception0.77161898
150MP0005584_abnormal_enzyme/coenzyme_acti0.76470412
151MP0000604_amyloidosis0.76189698
152MP0009745_abnormal_behavioral_response0.75597903
153MP0005647_abnormal_sex_gland0.74606542
154MP0000681_abnormal_thyroid_gland0.74449043
155MP0001765_abnormal_ion_homeostasis0.73868878
156MP0002572_abnormal_emotion/affect_behav0.73450448
157MP0009780_abnormal_chondrocyte_physiolo0.73007453
158MP0001970_abnormal_pain_threshold0.72532457
159MP0001851_eye_inflammation0.72471333
160MP0000465_gastrointestinal_hemorrhage0.72421649
161MP0004947_skin_inflammation0.71112502
162MP0004885_abnormal_endolymph0.70992488
163MP0002938_white_spotting0.70757922

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.52598346
2Hypothermia (HP:0002045)4.54834839
3Acute necrotizing encephalopathy (HP:0006965)3.97888422
4Acute encephalopathy (HP:0006846)3.84880113
5Abnormality of B cell number (HP:0010975)3.68438884
6Abnormal mitochondria in muscle tissue (HP:0008316)3.68434201
7Severe combined immunodeficiency (HP:0004430)3.54610427
8Intrahepatic cholestasis (HP:0001406)3.42986065
9Congenital stationary night blindness (HP:0007642)3.40647735
10Eosinophilia (HP:0001880)3.37891342
11Panhypogammaglobulinemia (HP:0003139)3.37373739
12Prolonged partial thromboplastin time (HP:0003645)3.37119079
13Pancreatic cysts (HP:0001737)3.36010957
14Mitochondrial inheritance (HP:0001427)3.32633899
15Progressive macrocephaly (HP:0004481)3.25125400
16Stomatitis (HP:0010280)3.24790591
17Hepatic necrosis (HP:0002605)3.20955173
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.17462746
19Attenuation of retinal blood vessels (HP:0007843)3.17034866
20Hepatocellular necrosis (HP:0001404)3.16084450
21Granulocytopenia (HP:0001913)3.12108216
22Cerebral edema (HP:0002181)3.07844576
23Hypoglycemic coma (HP:0001325)3.03834291
24Abnormality of eosinophils (HP:0001879)3.02602685
25Autoimmune hemolytic anemia (HP:0001890)3.01874637
26Abnormal rod and cone electroretinograms (HP:0008323)2.98873428
27Abnormality of T cell number (HP:0011839)2.97525314
28Elevated erythrocyte sedimentation rate (HP:0003565)2.96933856
29Leukocytosis (HP:0001974)2.92642231
30Increased CSF lactate (HP:0002490)2.89136751
31Hypoglycemic seizures (HP:0002173)2.87026318
32B lymphocytopenia (HP:0010976)2.85667961
33Thyroiditis (HP:0100646)2.84634376
34Autoimmune thrombocytopenia (HP:0001973)2.84170257
35Ketosis (HP:0001946)2.80753373
36Generalized aminoaciduria (HP:0002909)2.77410893
373-Methylglutaconic aciduria (HP:0003535)2.77329444
38Symptomatic seizures (HP:0011145)2.75528795
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73829907
40Conjugated hyperbilirubinemia (HP:0002908)2.72669587
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.72277705
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.70925204
43Combined immunodeficiency (HP:0005387)2.68506448
44Hypoproteinemia (HP:0003075)2.68025583
45Ketoacidosis (HP:0001993)2.66995432
46Abnormality of midbrain morphology (HP:0002418)2.66625560
47Molar tooth sign on MRI (HP:0002419)2.66625560
48Fat malabsorption (HP:0002630)2.65722501
49Recurrent gram-negative bacterial infections (HP:0005420)2.61997519
50Hyperinsulinemic hypoglycemia (HP:0000825)2.60044644
51Abnormality of T cells (HP:0002843)2.59209425
52Abnormality of methionine metabolism (HP:0010901)2.58483922
53Abnormality of the renal cortex (HP:0011035)2.58072966
54Abnormality of the prostate (HP:0008775)2.57921202
55Glycosuria (HP:0003076)2.54907109
56Abnormality of urine glucose concentration (HP:0011016)2.54907109
57Methylmalonic acidemia (HP:0002912)2.53356473
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.52540047
59Hypochromic anemia (HP:0001931)2.47834609
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47776323
61Enlarged kidneys (HP:0000105)2.47753198
62Stomach cancer (HP:0012126)2.45811688
63Osteomalacia (HP:0002749)2.43986900
64Increased IgM level (HP:0003496)2.42623164
65Pancreatic islet-cell hyperplasia (HP:0004510)2.42432742
66Hypoplasia of the thymus (HP:0000778)2.42213152
67IgG deficiency (HP:0004315)2.41760810
68Lethargy (HP:0001254)2.40816923
69Congenital sensorineural hearing impairment (HP:0008527)2.40692471
70Lactic acidosis (HP:0003128)2.39659502
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39616496
72Severe visual impairment (HP:0001141)2.38773119
73Renal Fanconi syndrome (HP:0001994)2.38602656
74Lipid accumulation in hepatocytes (HP:0006561)2.36815016
75Steatorrhea (HP:0002570)2.35182370
76Hyperphosphaturia (HP:0003109)2.34564225
77Abnormality of T cell physiology (HP:0011840)2.33662519
78Type I transferrin isoform profile (HP:0003642)2.33625029
79Nephronophthisis (HP:0000090)2.33398953
80T lymphocytopenia (HP:0005403)2.30202677
81Tubulointerstitial nephritis (HP:0001970)2.26721930
82Abnormality of endocrine pancreas physiology (HP:0012093)2.26538740
83Abnormality of the pancreatic islet cells (HP:0006476)2.26538740
84Prostate neoplasm (HP:0100787)2.25260437
85Acanthocytosis (HP:0001927)2.24121544
86Abnormal number of erythroid precursors (HP:0012131)2.24045677
87True hermaphroditism (HP:0010459)2.23015117
88Abnormal pupillary function (HP:0007686)2.22834585
89Neuroendocrine neoplasm (HP:0100634)2.20886384
90Respiratory failure (HP:0002878)2.20550115
91Lip pit (HP:0100267)2.20384922
92Hyperbilirubinemia (HP:0002904)2.20289362
93Hypobetalipoproteinemia (HP:0003563)2.18516929
94Abolished electroretinogram (ERG) (HP:0000550)2.18300837
95Recurrent abscess formation (HP:0002722)2.17696078
96Medial flaring of the eyebrow (HP:0010747)2.16917684
97Decreased central vision (HP:0007663)2.15828788
98Abnormality of fatty-acid metabolism (HP:0004359)2.14808787
99Agammaglobulinemia (HP:0004432)2.14611254
100Palpitations (HP:0001962)2.13904325
101Chronic hepatic failure (HP:0100626)2.13762092
102Dysautonomia (HP:0002459)2.12095242
103Methylmalonic aciduria (HP:0012120)2.11669283
104Dicarboxylic aciduria (HP:0003215)2.11048235
105Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11048235
106Acute hepatic failure (HP:0006554)2.10787624
107Increased hepatocellular lipid droplets (HP:0006565)2.09814147
108Abnormal drinking behavior (HP:0030082)2.08718082
109Polydipsia (HP:0001959)2.08718082
110Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08629933
111Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08629933
112Abnormality of macular pigmentation (HP:0008002)2.08370282
113Gait imbalance (HP:0002141)2.07195915
114Optic disc pallor (HP:0000543)2.06860489
115Congenital primary aphakia (HP:0007707)2.06466403
116Abnormality of vitamin metabolism (HP:0100508)2.06067176
117Abnormality of the renal medulla (HP:0100957)2.06005903
118Retinal dysplasia (HP:0007973)2.05824847
119Renal tubular dysfunction (HP:0000124)2.04551862
120Hypoplasia of the fovea (HP:0007750)2.01245698
121Aplasia/Hypoplasia of the fovea (HP:0008060)2.01245698
122Hyperammonemia (HP:0001987)2.01053946
123Delayed CNS myelination (HP:0002188)2.00484476
124Synostosis involving the elbow (HP:0003938)2.00393062
125Humeroradial synostosis (HP:0003041)2.00393062
126Abnormal tarsal ossification (HP:0008369)1.99512913
127Abnormality of renal resorption (HP:0011038)1.98576921
128Respiratory distress (HP:0002098)1.97563612
129Alveolar cell carcinoma (HP:0006519)1.96209306
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95643009
131Abnormal protein N-linked glycosylation (HP:0012347)1.95643009
132Abnormal protein glycosylation (HP:0012346)1.95643009
133Abnormal glycosylation (HP:0012345)1.95643009
134Abnormality of vitamin B metabolism (HP:0004340)1.94399485
135Meningitis (HP:0001287)1.92833569
136Renal cortical cysts (HP:0000803)1.92515207
137Abnormality of the intrinsic pathway (HP:0010989)1.92242982
138Nasolacrimal duct obstruction (HP:0000579)1.91567573
139Limb hypertonia (HP:0002509)1.91513480
140Pheochromocytoma (HP:0002666)1.90842913
141Recurrent fungal infections (HP:0002841)1.90606568
142Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89720468
143Opisthotonus (HP:0002179)1.89442281
144Cortical visual impairment (HP:0100704)1.89345086
145Abnormality of the fovea (HP:0000493)1.88922526
146Nephrogenic diabetes insipidus (HP:0009806)1.88401254
147Deep venous thrombosis (HP:0002625)1.88228396
148Abnormality of transition element cation homeostasis (HP:0011030)1.87012102
149Pancreatic fibrosis (HP:0100732)1.86877501
150Xanthomatosis (HP:0000991)1.86660733
151Increased serum lactate (HP:0002151)1.86660174
152Abnormal urine phosphate concentration (HP:0012599)1.85895893
153Poor suck (HP:0002033)1.84949024
154Pustule (HP:0200039)1.84392658
155Myositis (HP:0100614)1.83857249
156Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82732425
157Cystic liver disease (HP:0006706)1.82178606
158Brushfield spots (HP:0001088)1.80366108
159Progressive neurologic deterioration (HP:0002344)1.80195968
160Neutropenia (HP:0001875)1.79379080
161Vasculitis (HP:0002633)1.78053532
162Abnormality of the renal collecting system (HP:0004742)1.77143101
163Metabolic acidosis (HP:0001942)1.76831897
164Retrobulbar optic neuritis (HP:0100654)1.75667363
165Optic neuritis (HP:0100653)1.75667363
166Neoplasm of the tracheobronchial system (HP:0100552)1.75513773
167Encephalitis (HP:0002383)1.75449135
168Abnormality of cells of the erythroid lineage (HP:0012130)1.75393552
169Bony spicule pigmentary retinopathy (HP:0007737)1.74419142
170Abnormality of male internal genitalia (HP:0000022)1.72455454
171Hypochromic microcytic anemia (HP:0004840)1.72420158
172Macular degeneration (HP:0000608)1.71819451
173Polyuria (HP:0000103)1.71478118
174Cerebellar dysplasia (HP:0007033)1.70359258
175Abnormal biliary tract physiology (HP:0012439)1.69269302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.45008014
2MAP4K14.02473635
3INSRR3.91459169
4MAPK153.10534951
5BCKDK2.68616549
6MST42.65830767
7BCR2.56523476
8WNK32.55390678
9TNIK2.42254390
10STK162.35994357
11FRK2.31738171
12CDK192.28000219
13NUAK11.96271449
14OXSR11.91228885
15BMPR21.87285008
16STK391.87283163
17FES1.81983398
18MAP4K21.77949622
19TNK21.76758449
20MAP2K71.75490681
21CASK1.73045572
22SIK31.70481354
23WNK41.66830178
24HIPK21.65142346
25MAP3K121.61991256
26PRKCH1.58594780
27MAP3K41.55271835
28ITK1.47656651
29GRK61.41508108
30ACVR1B1.41074335
31EIF2AK31.40984509
32VRK21.40349137
33CAMKK21.38023068
34IKBKB1.38022118
35ERBB31.37607044
36MUSK1.35258251
37NTRK11.34787373
38BMPR1B1.33885926
39PIK3CG1.29965184
40IKBKE1.28387360
41CSNK1G31.27757205
42IRAK31.26816675
43PBK1.25685003
44NME21.25361284
45AKT31.24944809
46GRK71.24663590
47MAP3K21.24094653
48IRAK41.23740801
49PASK1.23038856
50ADRBK21.21758274
51LCK1.20576768
52SGK2231.15819456
53SGK4941.15819456
54ZAK1.14565605
55TLK11.14357275
56MAPKAPK51.13234168
57CAMK2D1.10749558
58CSNK1G11.06367900
59TEC1.04648806
60CAMK2G1.04107161
61KDR1.04045608
62JAK31.02205673
63DYRK21.00411215
64YES10.92949579
65RIPK40.92288232
66ZAP700.91840233
67BLK0.90575422
68GRK50.88522811
69MAP3K110.88125779
70DYRK1B0.87693271
71PRKCE0.86986449
72DAPK20.86726539
73MAPK130.86426581
74PINK10.83958299
75CSNK1A1L0.83880307
76EPHB10.82674192
77HCK0.81317633
78DYRK30.78872580
79MARK30.76811501
80VRK10.76102024
81SGK20.75433235
82PTK2B0.73815478
83CAMK2A0.73548891
84CSNK1G20.73372602
85SYK0.73201800
86PIM20.72634366
87UHMK10.72429395
88RPS6KA50.71664078
89MATK0.71318964
90IRAK10.71156918
91PIM10.71014241
92BRD40.70956649
93MKNK20.69348448
94DYRK1A0.68584273
95NTRK30.68222263
96CLK10.67212811
97TYK20.66079135
98LIMK10.65496597
99RPS6KB10.62977272
100CSF1R0.62970918
101TGFBR10.62592588
102MAPK110.62364350
103PRKACA0.59275463
104MAP2K60.58909554
105GRK10.57702626
106TRIM280.57236201
107TBK10.56647911
108ARAF0.54783527
109CDK30.54718740
110PRPF4B0.54306230
111PRKCG0.54115192
112FLT30.52087691
113DAPK10.51782205
114CSNK1A10.51394860
115NME10.51376395
116EPHA30.51103691
117BTK0.50499292
118GSK3A0.48954899
119MINK10.48873614
120CSK0.47685400
121MAP3K140.47169723
122NEK60.46084519
123PKN10.45509164
124PRKCD0.45254520
125CAMK2B0.44329030
126PRKCQ0.42377585
127KIT0.42233044
128IRAK20.42178936
129PAK30.41068332
130LYN0.39230929
131TAF10.38713559
132MYLK0.37841195
133MAPK40.37352903
134PHKG10.37249275
135PHKG20.37249275
136ADRBK10.37231876
137JAK20.37147881
138PRKCA0.37028598
139NLK0.35591038
140CDK80.34868877
141TAOK30.34022944
142PLK40.33290518
143MAP3K10.32004773
144CAMKK10.31669063
145STK110.29467158
146ATR0.29020095
147ABL10.28513138
148PRKCB0.27220562
149OBSCN0.26716924
150IGF1R0.26250542

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.57427072
2Protein export_Homo sapiens_hsa030603.39401338
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.11650786
4Graft-versus-host disease_Homo sapiens_hsa053322.86422302
5Allograft rejection_Homo sapiens_hsa053302.85497895
6RNA polymerase_Homo sapiens_hsa030202.81403231
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.80363719
8Autoimmune thyroid disease_Homo sapiens_hsa053202.79369788
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.61360909
10Oxidative phosphorylation_Homo sapiens_hsa001902.57319034
11Type I diabetes mellitus_Homo sapiens_hsa049402.51605499
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.50501544
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.42858796
14Asthma_Homo sapiens_hsa053102.41657574
15Histidine metabolism_Homo sapiens_hsa003402.40940523
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34608881
17Fatty acid elongation_Homo sapiens_hsa000622.29008350
18Chemical carcinogenesis_Homo sapiens_hsa052042.18482185
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17233161
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14548712
21Folate biosynthesis_Homo sapiens_hsa007902.06523730
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06149703
23Parkinsons disease_Homo sapiens_hsa050122.01974098
24Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00350582
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96910652
26Tryptophan metabolism_Homo sapiens_hsa003801.93021431
27Peroxisome_Homo sapiens_hsa041461.92478727
28Phototransduction_Homo sapiens_hsa047441.85220977
29Staphylococcus aureus infection_Homo sapiens_hsa051501.83394011
30Propanoate metabolism_Homo sapiens_hsa006401.77994646
31Butanoate metabolism_Homo sapiens_hsa006501.76362649
32Steroid biosynthesis_Homo sapiens_hsa001001.65203308
33Fatty acid degradation_Homo sapiens_hsa000711.65142608
34Alzheimers disease_Homo sapiens_hsa050101.55888934
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54625280
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.53621362
37Tyrosine metabolism_Homo sapiens_hsa003501.50917767
38beta-Alanine metabolism_Homo sapiens_hsa004101.47394810
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46717459
40Phenylalanine metabolism_Homo sapiens_hsa003601.44250571
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42688655
42Retinol metabolism_Homo sapiens_hsa008301.42157659
43Hematopoietic cell lineage_Homo sapiens_hsa046401.41096558
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38240394
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37469071
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36945095
47Pyruvate metabolism_Homo sapiens_hsa006201.35167986
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32536881
49Leishmaniasis_Homo sapiens_hsa051401.31655333
50Antigen processing and presentation_Homo sapiens_hsa046121.31654913
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31477890
52Rheumatoid arthritis_Homo sapiens_hsa053231.30241267
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27709882
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.25086825
55Homologous recombination_Homo sapiens_hsa034401.19409475
56Olfactory transduction_Homo sapiens_hsa047401.19026440
57Fanconi anemia pathway_Homo sapiens_hsa034601.18991108
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16828429
59Huntingtons disease_Homo sapiens_hsa050161.16466163
60Viral myocarditis_Homo sapiens_hsa054161.16445013
61Arginine biosynthesis_Homo sapiens_hsa002201.14077180
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14009447
63Basal transcription factors_Homo sapiens_hsa030221.13363104
64Glutathione metabolism_Homo sapiens_hsa004801.11762381
65Fatty acid metabolism_Homo sapiens_hsa012121.09968477
66Arginine and proline metabolism_Homo sapiens_hsa003301.09275939
67RNA degradation_Homo sapiens_hsa030181.09263810
68Starch and sucrose metabolism_Homo sapiens_hsa005001.07466880
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06382728
70Pyrimidine metabolism_Homo sapiens_hsa002401.01206592
71Caffeine metabolism_Homo sapiens_hsa002321.01038693
72Proteasome_Homo sapiens_hsa030500.98400081
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95263281
74Complement and coagulation cascades_Homo sapiens_hsa046100.93510554
75Collecting duct acid secretion_Homo sapiens_hsa049660.91552070
76* Purine metabolism_Homo sapiens_hsa002300.89146654
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89087247
78Metabolic pathways_Homo sapiens_hsa011000.88896220
79Linoleic acid metabolism_Homo sapiens_hsa005910.88267703
80PPAR signaling pathway_Homo sapiens_hsa033200.86717423
81Non-homologous end-joining_Homo sapiens_hsa034500.85877870
82ABC transporters_Homo sapiens_hsa020100.84640680
83T cell receptor signaling pathway_Homo sapiens_hsa046600.84320526
84Galactose metabolism_Homo sapiens_hsa000520.82438363
85Vibrio cholerae infection_Homo sapiens_hsa051100.80591746
86Measles_Homo sapiens_hsa051620.79284472
87Legionellosis_Homo sapiens_hsa051340.77773553
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76708911
89Insulin secretion_Homo sapiens_hsa049110.75408022
90Selenocompound metabolism_Homo sapiens_hsa004500.73512295
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72530774
92N-Glycan biosynthesis_Homo sapiens_hsa005100.71136536
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71037106
94Cocaine addiction_Homo sapiens_hsa050300.70753193
95Ether lipid metabolism_Homo sapiens_hsa005650.68109522
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.67905783
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.65724709
98Herpes simplex infection_Homo sapiens_hsa051680.64952535
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64891771
100Vitamin B6 metabolism_Homo sapiens_hsa007500.64883969
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64757592
102Nitrogen metabolism_Homo sapiens_hsa009100.64092362
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61677669
104Serotonergic synapse_Homo sapiens_hsa047260.61606949
105Glycerolipid metabolism_Homo sapiens_hsa005610.61424645
106Bile secretion_Homo sapiens_hsa049760.61237403
107Malaria_Homo sapiens_hsa051440.59242603
108Arachidonic acid metabolism_Homo sapiens_hsa005900.58689840
109Ribosome_Homo sapiens_hsa030100.58142770
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57545272
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57205224
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56473148
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56347059
114Tuberculosis_Homo sapiens_hsa051520.53066857
115Regulation of autophagy_Homo sapiens_hsa041400.51721965
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.51063301
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49883547
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.49543158
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48539746
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42028736
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40454702
122Fat digestion and absorption_Homo sapiens_hsa049750.40441531
123Systemic lupus erythematosus_Homo sapiens_hsa053220.40024419
124Pentose phosphate pathway_Homo sapiens_hsa000300.40003099
125Ovarian steroidogenesis_Homo sapiens_hsa049130.39852816
126Mismatch repair_Homo sapiens_hsa034300.39607944
127Synaptic vesicle cycle_Homo sapiens_hsa047210.39566847
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39061065
129Morphine addiction_Homo sapiens_hsa050320.38956484
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38596555
131Osteoclast differentiation_Homo sapiens_hsa043800.38451965
132Spliceosome_Homo sapiens_hsa030400.36027187
133Sphingolipid metabolism_Homo sapiens_hsa006000.35286670
134Vitamin digestion and absorption_Homo sapiens_hsa049770.34550369
135Taste transduction_Homo sapiens_hsa047420.32650353
136African trypanosomiasis_Homo sapiens_hsa051430.31689690
137GABAergic synapse_Homo sapiens_hsa047270.29866073
138Circadian rhythm_Homo sapiens_hsa047100.29842734
139Sulfur relay system_Homo sapiens_hsa041220.28601381
140Cardiac muscle contraction_Homo sapiens_hsa042600.27146672
141Carbon metabolism_Homo sapiens_hsa012000.22999693
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.20829801
143Amphetamine addiction_Homo sapiens_hsa050310.20419580
144Primary immunodeficiency_Homo sapiens_hsa053400.19845332
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19303191
146Fructose and mannose metabolism_Homo sapiens_hsa000510.17389056
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.17056832
148Prion diseases_Homo sapiens_hsa050200.15400405

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