FHL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1creatine metabolic process (GO:0006600)7.95719987
2actin filament-based movement (GO:0030048)7.77232671
3regulation of relaxation of muscle (GO:1901077)7.38232744
4striated muscle contraction (GO:0006941)7.30285616
5response to muscle activity (GO:0014850)7.21902628
6skeletal muscle fiber development (GO:0048741)7.00145314
7myofibril assembly (GO:0030239)6.92717628
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.56059707
9positive regulation of protein kinase C signaling (GO:0090037)6.55004521
10sarcomere organization (GO:0045214)6.21895647
11myotube cell development (GO:0014904)6.18445745
12negative regulation of execution phase of apoptosis (GO:1900118)6.14708862
13short-term memory (GO:0007614)5.99538833
14glycogen catabolic process (GO:0005980)5.88142763
15response to inactivity (GO:0014854)5.85844454
16presynaptic membrane assembly (GO:0097105)5.83677941
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.71734551
18plasma membrane repair (GO:0001778)5.70303462
19skeletal muscle adaptation (GO:0043501)5.68885164
20muscle contraction (GO:0006936)5.68290728
21postsynaptic membrane organization (GO:0001941)5.64083194
22glucan catabolic process (GO:0009251)5.56517757
23cellular polysaccharide catabolic process (GO:0044247)5.25518314
24glycogen biosynthetic process (GO:0005978)5.14597245
25glucan biosynthetic process (GO:0009250)5.14597245
26cardiac muscle contraction (GO:0060048)5.08347813
27cardiac myofibril assembly (GO:0055003)5.07112691
28muscle system process (GO:0003012)5.06819838
29skeletal muscle tissue regeneration (GO:0043403)5.03700116
30NADH metabolic process (GO:0006734)4.99694385
31presynaptic membrane organization (GO:0097090)4.87575549
32positive regulation of myotube differentiation (GO:0010831)4.80191732
33muscle fiber development (GO:0048747)4.78309501
34skeletal muscle tissue development (GO:0007519)4.73340051
35actomyosin structure organization (GO:0031032)4.72872648
36regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.72391899
37polysaccharide catabolic process (GO:0000272)4.71758867
38muscle organ morphogenesis (GO:0048644)4.53608610
39negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.47989330
40fructose metabolic process (GO:0006000)4.45829587
41axon ensheathment in central nervous system (GO:0032291)4.41232558
42central nervous system myelination (GO:0022010)4.41232558
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.38748748
44spermatid nucleus differentiation (GO:0007289)4.33111187
452-oxoglutarate metabolic process (GO:0006103)4.30945894
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.26584525
47protein heterotetramerization (GO:0051290)4.24733508
48regulation of actin filament-based movement (GO:1903115)4.24297157
49striated muscle adaptation (GO:0014888)4.23950974
50metanephric nephron tubule development (GO:0072234)4.16499758
51metanephric tubule development (GO:0072170)4.16499758
52glycogen metabolic process (GO:0005977)4.15241152
53muscle cell fate commitment (GO:0042693)4.14148819
54muscle cell cellular homeostasis (GO:0046716)4.14114515
55response to activity (GO:0014823)4.12774929
56IMP metabolic process (GO:0046040)4.10316737
57cellular glucan metabolic process (GO:0006073)4.08108260
58glucan metabolic process (GO:0044042)4.08108260
59cardiac muscle hypertrophy (GO:0003300)4.07341433
60gluconeogenesis (GO:0006094)4.05960885
61negative regulation of potassium ion transmembrane transport (GO:1901380)4.04236165
62GMP metabolic process (GO:0046037)4.02097563
63interkinetic nuclear migration (GO:0022027)3.98754461
64regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.96835704
65metanephric nephron epithelium development (GO:0072243)3.91298190
66regulation of cell communication by electrical coupling (GO:0010649)3.89962329
67endothelium development (GO:0003158)3.89368174
68striated muscle hypertrophy (GO:0014897)3.89185683
69positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.88856503
70melanin metabolic process (GO:0006582)3.80608418
71metanephric epithelium development (GO:0072207)3.75395098
72neuronal action potential propagation (GO:0019227)3.73914923
73muscle tissue morphogenesis (GO:0060415)3.73172442
74cranial nerve morphogenesis (GO:0021602)3.72276199
75negative regulation of necroptotic process (GO:0060546)3.70506232
76regulation of pigment cell differentiation (GO:0050932)3.70295980
77limb bud formation (GO:0060174)3.67723129
78organ growth (GO:0035265)3.67365631
79facial nerve structural organization (GO:0021612)3.65692124
80hexose biosynthetic process (GO:0019319)3.65586536
81muscle adaptation (GO:0043500)3.63839175
82negative regulation of muscle contraction (GO:0045932)3.63581275
83tricarboxylic acid cycle (GO:0006099)3.62977616
84nephron epithelium development (GO:0072009)3.61029535
85striated muscle cell development (GO:0055002)3.60853541
86muscle hypertrophy (GO:0014896)3.60413493
87* muscle organ development (GO:0007517)3.57595717
88* muscle structure development (GO:0061061)3.56709088
89viral transcription (GO:0019083)3.54898584
90regulation of striated muscle contraction (GO:0006942)3.54526934
91melanin biosynthetic process (GO:0042438)3.52591363
92purine nucleotide salvage (GO:0032261)3.51506389
93ribosomal small subunit biogenesis (GO:0042274)3.51434624
94regulation of protein kinase C signaling (GO:0090036)3.49302654
95striated muscle atrophy (GO:0014891)3.46862269
96cardiac muscle tissue morphogenesis (GO:0055008)3.45165818
97GTP biosynthetic process (GO:0006183)3.43083174
98myoblast fusion (GO:0007520)3.41068907
99retina layer formation (GO:0010842)3.38238207
100AMP metabolic process (GO:0046033)3.37629456
101negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.36707191
102negative regulation of calcium ion transmembrane transport (GO:1903170)3.36707191
103regulation of myoblast differentiation (GO:0045661)3.36020751
104oxaloacetate metabolic process (GO:0006107)3.33554670
105ubiquinone biosynthetic process (GO:0006744)3.30122097
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.28824972
107regulation of calcium ion transmembrane transporter activity (GO:1901019)3.28270748
108regulation of calcium ion transmembrane transport (GO:1903169)3.28270748
109monosaccharide biosynthetic process (GO:0046364)3.27303813
110regulation of myotube differentiation (GO:0010830)3.25510707
111regulation of protein kinase A signaling (GO:0010738)3.24170930
112mesonephros development (GO:0001823)3.23753165
113translational termination (GO:0006415)3.20167812
114muscle cell development (GO:0055001)3.16464178
115cellular carbohydrate catabolic process (GO:0044275)3.16208772
116succinate metabolic process (GO:0006105)3.14670514
117eyelid development in camera-type eye (GO:0061029)3.14389776
118syncytium formation by plasma membrane fusion (GO:0000768)3.14177453
119adult heart development (GO:0007512)3.12857320
120striated muscle tissue development (GO:0014706)3.12739761
121regulation of sequestering of triglyceride (GO:0010889)3.11528375
122cardiac muscle adaptation (GO:0014887)3.09823047
123cardiac muscle hypertrophy in response to stress (GO:0014898)3.09823047
124muscle hypertrophy in response to stress (GO:0003299)3.09823047
125cellular polysaccharide biosynthetic process (GO:0033692)3.09146600
126muscle atrophy (GO:0014889)3.08701607
127positive regulation of cellular amine metabolic process (GO:0033240)3.08525283
128heart contraction (GO:0060047)3.08270737
129heart process (GO:0003015)3.08270737
130regulation of timing of cell differentiation (GO:0048505)3.07473067
131negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.06749272
132lymphoid progenitor cell differentiation (GO:0002320)3.05871950
133cranial nerve structural organization (GO:0021604)3.02760604
134import into cell (GO:0098657)3.01701074
135regulation of development, heterochronic (GO:0040034)3.01166509
136response to folic acid (GO:0051593)3.01034996
137branch elongation of an epithelium (GO:0060602)3.00044183
138positive regulation of steroid hormone secretion (GO:2000833)2.97601260
139mesenchymal cell differentiation involved in kidney development (GO:0072161)2.97453476
140mesenchymal cell differentiation involved in renal system development (GO:2001012)2.97453476
141secondary metabolite biosynthetic process (GO:0044550)2.94824479
142regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.93660853
143omega-hydroxylase P450 pathway (GO:0097267)2.85222953
144positive regulation of calcium ion import (GO:0090280)2.83069359
145DNA methylation involved in gamete generation (GO:0043046)2.81685626
146mature B cell differentiation (GO:0002335)2.80991454
147negative regulation of leukocyte chemotaxis (GO:0002689)2.79791847
148cotranslational protein targeting to membrane (GO:0006613)2.79488051
149SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79043447
150protein targeting to ER (GO:0045047)2.78758696
151pattern specification involved in kidney development (GO:0061004)2.78594577
152negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.75554417
153cornea development in camera-type eye (GO:0061303)2.74036599
154UTP biosynthetic process (GO:0006228)2.72947732
155nephron tubule development (GO:0072080)2.72625943
156UV protection (GO:0009650)2.70272859
157membrane assembly (GO:0071709)2.67246183
158endocrine hormone secretion (GO:0060986)2.65898178
159positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.65759721
160establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63880803
161otic vesicle formation (GO:0030916)2.63697294
162negative regulation of keratinocyte proliferation (GO:0010839)2.62971311
163negative regulation of Ras GTPase activity (GO:0034261)2.58619887
164thyroid gland development (GO:0030878)2.57344914
165cell proliferation in forebrain (GO:0021846)2.57334419
166negative regulation of transcription by competitive promoter binding (GO:0010944)2.57009945
167forebrain neuron differentiation (GO:0021879)2.56684399
168superoxide anion generation (GO:0042554)2.55910367
169cilium movement (GO:0003341)2.54493858
170protein localization to endoplasmic reticulum (GO:0070972)2.54235802
171sympathetic nervous system development (GO:0048485)2.52042181
172keratinocyte development (GO:0003334)2.51943083
173developmental pigmentation (GO:0048066)2.45609456
174regulation of execution phase of apoptosis (GO:1900117)2.43939620
175proteasome assembly (GO:0043248)2.43773442
176renal tubule development (GO:0061326)2.41949200
177response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.38793506
178amino sugar catabolic process (GO:0046348)2.38344325
179response to peptidoglycan (GO:0032494)2.37980896
180forebrain neuron development (GO:0021884)2.36963162
181cerebral cortex radially oriented cell migration (GO:0021799)2.36944544
182centriole replication (GO:0007099)2.35472960
183neuron cell-cell adhesion (GO:0007158)2.35127663
184viral genome replication (GO:0019079)2.32563056
185generation of neurons (GO:0048699)2.32442993
186DNA ligation (GO:0006266)2.32138131
187mesenchymal to epithelial transition (GO:0060231)2.31438670
188spinal cord motor neuron differentiation (GO:0021522)2.29957467
189nephron tubule formation (GO:0072079)2.28271777
190Leydig cell differentiation (GO:0033327)2.28220524
191righting reflex (GO:0060013)2.28027489
192oligodendrocyte differentiation (GO:0048709)2.26818472
193RNA destabilization (GO:0050779)2.25938489
194actin-myosin filament sliding (GO:0033275)12.8371930
195muscle filament sliding (GO:0030049)12.8371930
196sarcoplasmic reticulum calcium ion transport (GO:0070296)11.5751175
197skeletal muscle contraction (GO:0003009)10.6444174
198actin-mediated cell contraction (GO:0070252)10.4415233
199regulation of skeletal muscle contraction (GO:0014819)10.1491943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67096594
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.77961750
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16255122
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.06721409
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.99852435
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.92710697
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.81096660
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.80038321
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76557413
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.73853165
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68060874
12BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.64484651
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.62137258
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.59611747
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.57150021
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.54449199
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.45561473
18TBX20_22328084_ChIP-Seq_HEART_Mouse2.42269544
19TBX20_22080862_ChIP-Seq_HEART_Mouse2.42269544
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30510561
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26734270
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26734270
23GBX2_23144817_ChIP-Seq_PC3_Human2.25510745
24TAF15_26573619_Chip-Seq_HEK293_Human2.24336861
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22236695
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20949882
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20493795
28AR_21572438_ChIP-Seq_LNCaP_Human2.19957032
29VDR_22108803_ChIP-Seq_LS180_Human2.17992897
30LXR_22292898_ChIP-Seq_THP-1_Human2.17297876
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14790445
32JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14358258
33PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12596716
34ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09951608
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06342761
36VDR_21846776_ChIP-Seq_THP-1_Human2.05903657
37SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02872976
38FLI1_27457419_Chip-Seq_LIVER_Mouse2.00276352
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99831293
40RNF2_27304074_Chip-Seq_NSC_Mouse1.99133086
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.97585549
42* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.92220051
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.91863180
44ZNF263_19887448_ChIP-Seq_K562_Human1.86677621
45* KDM2B_26808549_Chip-Seq_DND41_Human1.84757845
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82419330
47TCF7_22412390_ChIP-Seq_EML_Mouse1.82396049
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78720815
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.76248408
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74134627
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72992886
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.72610264
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.71974006
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70887758
55NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.70104319
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68302955
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.68177544
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67797383
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.67538729
60* MAF_26560356_Chip-Seq_TH1_Human1.66791645
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.63644410
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.63644410
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.63644410
64MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.63210625
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.61991384
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61548094
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61307327
68* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.61132739
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58463636
70CTCF_21964334_ChIP-Seq_BJAB-B_Human1.57689616
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56738342
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55261695
73CTCF_27219007_Chip-Seq_Bcells_Human1.51875673
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51033784
75* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50621775
76GATA4_21415370_ChIP-Seq_HL-1_Mouse1.50614658
77* SA1_27219007_Chip-Seq_Bcells_Human1.48465120
78RACK7_27058665_Chip-Seq_MCF-7_Human1.47992841
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.47325106
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47260165
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47060057
82* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47000016
83SPI1_20517297_ChIP-Seq_HL60_Human1.46274882
84MYC_22102868_ChIP-Seq_BL_Human1.45711260
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45014894
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.44197692
87ER_23166858_ChIP-Seq_MCF-7_Human1.44074027
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43570733
89IGF1R_20145208_ChIP-Seq_DFB_Human1.43236655
90CTCF_21964334_Chip-Seq_Bcells_Human1.42183494
91SMC3_22415368_ChIP-Seq_MEFs_Mouse1.41313722
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41125900
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.41002928
94* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40799825
95STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.40395329
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39230578
97IRF1_19129219_ChIP-ChIP_H3396_Human1.38521479
98SPI1_23127762_ChIP-Seq_K562_Human1.37274973
99* SA1_27219007_Chip-Seq_ERYTHROID_Human1.37067394
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35745860
101STAT1_20625510_ChIP-Seq_HELA_Human1.34692065
102CTCF_26484167_Chip-Seq_Bcells_Mouse1.33185048
103MAF_26560356_Chip-Seq_TH2_Human1.32732287
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32345333
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31045268
106P300_18555785_Chip-Seq_ESCs_Mouse1.29777514
107P53_22387025_ChIP-Seq_ESCs_Mouse1.29248355
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.29200196
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28900096
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27785612
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26879763
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26786642
113BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26401774
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.26046407
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.25816532
116P68_20966046_ChIP-Seq_HELA_Human1.25757713
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.25421937
118TP53_18474530_ChIP-ChIP_U2OS_Human1.24777952
119RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24369638
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.23916707
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23488024
122YY1_22570637_ChIP-Seq_MALME-3M_Human1.23453660
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23350351
124ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22952734
125P300_19829295_ChIP-Seq_ESCs_Human1.21329995
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21197483
127ELF1_20517297_ChIP-Seq_JURKAT_Human1.20691374
128VDR_24763502_ChIP-Seq_THP-1_Human1.19859267
129CLOCK_20551151_ChIP-Seq_293T_Human1.19093116
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19032660
131TP63_17297297_ChIP-ChIP_HaCaT_Human1.18786527
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18213710
133NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17942629
134CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17865850
135CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17735393
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17481327
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17175839
138RUNX1_22412390_ChIP-Seq_EML_Mouse1.16634159
139STAT3_18555785_Chip-Seq_ESCs_Mouse1.16614452
140* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15960611
141NCOR1_26117541_ChIP-Seq_K562_Human1.15781781
142KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15593765
143RING1B_27294783_Chip-Seq_NPCs_Mouse1.15462892
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15208540
145RXR_22158963_ChIP-Seq_LIVER_Mouse1.15110653
146ZFX_18555785_Chip-Seq_ESCs_Mouse1.12285256
147EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12269019
148MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12263100
149* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12218897
150SMAD3_21741376_ChIP-Seq_EPCs_Human1.11940769
151PIAS1_25552417_ChIP-Seq_VCAP_Human1.11819173
152DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11729391
153SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11510596
154TP63_19390658_ChIP-ChIP_HaCaT_Human1.10643260
155SOX2_18555785_Chip-Seq_ESCs_Mouse1.10509443
156OCT4_18555785_Chip-Seq_ESCs_Mouse1.10367363
157TET1_21451524_ChIP-Seq_MESCs_Mouse1.10227232
158CMYC_18555785_Chip-Seq_ESCs_Mouse1.10082644
159BCOR_27268052_Chip-Seq_Bcells_Human1.09857061
160GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09528023
161BCL6_27268052_Chip-Seq_Bcells_Human1.08749890
162UTX_26944678_Chip-Seq_JUKART_Human1.07792503
163ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07253447
164CRX_20693478_ChIP-Seq_RETINA_Mouse1.06148989
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04944710
166CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03368292
167PU1_27457419_Chip-Seq_LIVER_Mouse1.03331493
168CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02859439
169KLF4_18555785_Chip-Seq_ESCs_Mouse1.02704137
170FUS_26573619_Chip-Seq_HEK293_Human1.01763857
171RING1B_27294783_Chip-Seq_ESCs_Mouse1.01428855
172PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01332723
173ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00680986
174OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99433359
175CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99118643
176GATA1_19941826_ChIP-Seq_K562_Human0.98365875
177E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97937093
178* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97528228
179EGR1_19032775_ChIP-ChIP_M12_Human0.97307622
180CTCF_18555785_Chip-Seq_ESCs_Mouse0.97139357
181GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96741436
182SMC4_20622854_ChIP-Seq_HELA_Human0.96081666
183SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95978303
184KDM2B_26808549_Chip-Seq_JURKAT_Human0.94961534
185KDM2B_26808549_Chip-Seq_REH_Human0.94948046
186SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94006472
187CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93931240
188TAL1_26923725_Chip-Seq_HPCs_Mouse0.93585260
189OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93092240
190SMAD_19615063_ChIP-ChIP_OVARY_Human0.93079585
191PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91326240
192EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90277756
193SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90217193
194VDR_24787735_ChIP-Seq_THP-1_Human0.88685722
195TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88486828
196STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88179627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.94132856
2MP0003646_muscle_fatigue6.90113543
3MP0005409_darkened_coat_color5.80989006
4MP0000749_muscle_degeneration5.61101144
5MP0001188_hyperpigmentation5.31839380
6MP0004381_abnormal_hair_follicle4.82309450
7MP0009379_abnormal_foot_pigmentation4.30154468
8MP0004036_abnormal_muscle_relaxation4.18022954
9MP0005451_abnormal_body_composition4.08140779
10MP0002106_abnormal_muscle_physiology3.77347643
11MP0000747_muscle_weakness3.60554682
12MP0000759_abnormal_skeletal_muscle3.59320850
13MP0004087_abnormal_muscle_fiber3.33828715
14MP0005174_abnormal_tail_pigmentation3.32187677
15MP0006292_abnormal_olfactory_placode3.31643336
16MP0004233_abnormal_muscle_weight3.27656503
17MP0002332_abnormal_exercise_endurance3.27124637
18MP0005369_muscle_phenotype3.16973006
19MP0002269_muscular_atrophy2.97750218
20MP0000015_abnormal_ear_pigmentation2.86547676
21MP0004130_abnormal_muscle_cell2.75748981
22MP0004084_abnormal_cardiac_muscle2.73600941
23MP0002102_abnormal_ear_morphology2.68749927
24MP0005620_abnormal_muscle_contractility2.66305108
25MP0003724_increased_susceptibility_to2.62825714
26MP0005330_cardiomyopathy2.56946398
27MP0003880_abnormal_central_pattern2.50392761
28MP0003315_abnormal_perineum_morphology2.30174748
29MP0000733_abnormal_muscle_development2.23417524
30MP0006036_abnormal_mitochondrial_physio2.06278889
31MP0002972_abnormal_cardiac_muscle2.01880312
32MP0002177_abnormal_outer_ear1.95642739
33MP0004742_abnormal_vestibular_system1.91647374
34MP0003303_peritoneal_inflammation1.89423242
35MP0002108_abnormal_muscle_morphology1.87952809
36MP0002277_abnormal_respiratory_mucosa1.74330098
37MP0003938_abnormal_ear_development1.72584372
38MP0004510_myositis1.70905808
39MP0004145_abnormal_muscle_electrophysio1.58736327
40MP0002249_abnormal_larynx_morphology1.57070626
41MP0002837_dystrophic_cardiac_calcinosis1.56525346
42MP0000566_synostosis1.55392213
43MP0000049_abnormal_middle_ear1.53079483
44MP0010630_abnormal_cardiac_muscle1.51926764
45MP0009250_abnormal_appendicular_skeleto1.50282478
46MP0008260_abnormal_autophagy1.47708947
47MP0004484_altered_response_of1.46762891
48MP0005257_abnormal_intraocular_pressure1.40997957
49MP0005266_abnormal_metabolism1.39280051
50MP0002127_abnormal_cardiovascular_syste1.35003742
51MP0000579_abnormal_nail_morphology1.34155257
52MP0004185_abnormal_adipocyte_glucose1.33790288
53MP0000013_abnormal_adipose_tissue1.32848960
54MP0000751_myopathy1.31579270
55MP0001544_abnormal_cardiovascular_syste1.30350631
56MP0005385_cardiovascular_system_phenoty1.30350631
57MP0006138_congestive_heart_failure1.30021544
58MP0002095_abnormal_skin_pigmentation1.28627337
59MP0003221_abnormal_cardiomyocyte_apopto1.25660442
60MP0001986_abnormal_taste_sensitivity1.22432497
61MP0004215_abnormal_myocardial_fiber1.21532307
62MP0003937_abnormal_limbs/digits/tail_de1.20057429
63MP0001968_abnormal_touch/_nociception1.11391990
64MP0000026_abnormal_inner_ear1.11327993
65MP0008995_early_reproductive_senescence1.09453524
66MP0002971_abnormal_brown_adipose1.09262930
67MP0003436_decreased_susceptibility_to1.08416563
68MP0005171_absent_coat_pigmentation1.07438715
69MP0000467_abnormal_esophagus_morphology1.04843997
70MP0001346_abnormal_lacrimal_gland1.04747822
71MP0002933_joint_inflammation1.00755989
72MP0005666_abnormal_adipose_tissue1.00112712
73MP0003828_pulmonary_edema0.99810294
74MP0002282_abnormal_trachea_morphology0.97691837
75MP0004142_abnormal_muscle_tone0.96603218
76MP0002751_abnormal_autonomic_nervous0.96276774
77MP0005375_adipose_tissue_phenotype0.95576567
78MP0002638_abnormal_pupillary_reflex0.94961688
79MP0001661_extended_life_span0.94712813
80MP0003950_abnormal_plasma_membrane0.94672237
81MP0000750_abnormal_muscle_regeneration0.94647206
82MP0002148_abnormal_hypersensitivity_rea0.94285022
83MP0001340_abnormal_eyelid_morphology0.92064077
84MP0005000_abnormal_immune_tolerance0.91601225
85MP0004270_analgesia0.85168169
86MP0006276_abnormal_autonomic_nervous0.84719626
87MP0002098_abnormal_vibrissa_morphology0.83498502
88MP0003656_abnormal_erythrocyte_physiolo0.82436712
89MP0003385_abnormal_body_wall0.81160845
90MP0000465_gastrointestinal_hemorrhage0.80967294
91MP0001486_abnormal_startle_reflex0.80561958
92MP0000920_abnormal_myelination0.80078328
93MP0003718_maternal_effect0.79761903
94MP0005595_abnormal_vascular_smooth0.77769452
95MP0003011_delayed_dark_adaptation0.76056111
96MP0003705_abnormal_hypodermis_morpholog0.75924201
97MP0003941_abnormal_skin_development0.75769111
98MP0000631_abnormal_neuroendocrine_gland0.75217623
99MP0000613_abnormal_salivary_gland0.74701494
100MP0000003_abnormal_adipose_tissue0.74088888
101MP0002067_abnormal_sensory_capabilities0.73498183
102MP0003755_abnormal_palate_morphology0.72039657
103MP0000372_irregular_coat_pigmentation0.71262325
104MP0005670_abnormal_white_adipose0.70757503
105MP0000762_abnormal_tongue_morphology0.70249756
106MP0009785_altered_susceptibility_to0.69802860
107MP0001851_eye_inflammation0.68982550
108MP0001663_abnormal_digestive_system0.68822740
109MP0005423_abnormal_somatic_nervous0.68304719
110MP0005166_decreased_susceptibility_to0.66604071
111MP0010030_abnormal_orbit_morphology0.65234269
112MP0003806_abnormal_nucleotide_metabolis0.65139144
113MP0000681_abnormal_thyroid_gland0.64964630
114MP0002752_abnormal_somatic_nervous0.64805558
115MP0005083_abnormal_biliary_tract0.64008386
116MP0002419_abnormal_innate_immunity0.62796302
117MP0001963_abnormal_hearing_physiology0.62689312
118MP0001919_abnormal_reproductive_system0.62299690
119MP0008775_abnormal_heart_ventricle0.61993720
120MP0003045_fibrosis0.61703082
121MP0000266_abnormal_heart_morphology0.61457899
122MP0009764_decreased_sensitivity_to0.60836210
123MP0005381_digestive/alimentary_phenotyp0.60632316
124MP0009840_abnormal_foam_cell0.60142476
125MP0000858_altered_metastatic_potential0.59899989
126MP0002938_white_spotting0.59645139
127MP0001853_heart_inflammation0.59380220
128MP0000432_abnormal_head_morphology0.59329077
129MP0005025_abnormal_response_to0.59318137
130MP0001533_abnormal_skeleton_physiology0.59239161
131MP0004147_increased_porphyrin_level0.59225789
132MP0003137_abnormal_impulse_conducting0.59043413
133MP0005075_abnormal_melanosome_morpholog0.58672868
134MP0000383_abnormal_hair_follicle0.58348001
135MP0001970_abnormal_pain_threshold0.58020781
136MP0002160_abnormal_reproductive_system0.57615552
137MP0005164_abnormal_response_to0.57394312
138MP0005167_abnormal_blood-brain_barrier0.57287055
139MP0005084_abnormal_gallbladder_morpholo0.56043096
140MP0005165_increased_susceptibility_to0.55909944
141MP0000343_altered_response_to0.55609473
142MP0002272_abnormal_nervous_system0.55450662
143MP0000647_abnormal_sebaceous_gland0.53330837
144MP0005671_abnormal_response_to0.53061674
145MP0002557_abnormal_social/conspecific_i0.52997760
146MP0002723_abnormal_immune_serum0.52908063
147MP0001286_abnormal_eye_development0.52591890
148MP0000778_abnormal_nervous_system0.52091782
149MP0003935_abnormal_craniofacial_develop0.51996542
150MP0009333_abnormal_splenocyte_physiolog0.51591214
151MP0003448_altered_tumor_morphology0.51585722
152MP0002998_abnormal_bone_remodeling0.51180180
153MP0004134_abnormal_chest_morphology0.50588312
154MP0001664_abnormal_digestion0.50292314
155MP0005197_abnormal_uvea_morphology0.50253659
156MP0002116_abnormal_craniofacial_bone0.50185004
157MP0005376_homeostasis/metabolism_phenot0.47227877
158MP0002822_catalepsy0.46690150
159MP0005058_abnormal_lysosome_morphology0.46442632
160MP0003191_abnormal_cellular_cholesterol0.45514058
161MP0004858_abnormal_nervous_system0.44114147
162MP0005584_abnormal_enzyme/coenzyme_acti0.43657550
163MP0005319_abnormal_enzyme/_coenzyme0.43508323
164MP0002128_abnormal_blood_circulation0.42894363
165MP0004085_abnormal_heartbeat0.42306580
166MP0003279_aneurysm0.41446107
167MP0002078_abnormal_glucose_homeostasis0.41429702
168MP0003879_abnormal_hair_cell0.41009800
169MP0009278_abnormal_bone_marrow0.39367248
170MP0005464_abnormal_platelet_physiology0.38030412
171MP0005535_abnormal_body_temperature0.37516050
172MP0006035_abnormal_mitochondrial_morpho0.37030827
173MP0003075_altered_response_to0.35555903
174MP0002896_abnormal_bone_mineralization0.33982619
175MP0001299_abnormal_eye_distance/0.33328118
176MP0002132_abnormal_respiratory_system0.32979453
177MP0002114_abnormal_axial_skeleton0.32610350
178MP0009672_abnormal_birth_weight0.32357808
179MP0005334_abnormal_fat_pad0.29921652
180MP0003948_abnormal_gas_homeostasis0.29430977
181MP0000678_abnormal_parathyroid_gland0.28851992
182MP0005452_abnormal_adipose_tissue0.28089001
183MP0008438_abnormal_cutaneous_collagen0.27904145
184MP0008874_decreased_physiological_sensi0.26196825
185MP0000249_abnormal_blood_vessel0.26158630
186MP0003959_abnormal_lean_body0.24426143

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)8.50415100
2Exercise-induced myalgia (HP:0003738)8.30758672
3Exercise-induced muscle cramps (HP:0003710)7.47943707
4Myopathic facies (HP:0002058)6.16156566
5Distal arthrogryposis (HP:0005684)6.08246963
6EMG: myopathic abnormalities (HP:0003458)5.23237662
7Calf muscle hypertrophy (HP:0008981)5.23132925
8Rhabdomyolysis (HP:0003201)5.04015493
9Centrally nucleated skeletal muscle fibers (HP:0003687)4.95690324
10Ulnar deviation of the wrist (HP:0003049)4.92883440
11Myoglobinuria (HP:0002913)4.80692313
12Muscle fiber splitting (HP:0003555)4.77326718
13Abnormality of skeletal muscle fiber size (HP:0012084)4.67075273
14Hyporeflexia of lower limbs (HP:0002600)4.42217808
15Sex reversal (HP:0012245)4.39278789
16Abnormal sex determination (HP:0012244)4.39278789
17Neck muscle weakness (HP:0000467)4.37266878
18Calcaneovalgus deformity (HP:0001848)4.31605467
19Abnormality of the calf musculature (HP:0001430)4.22861382
20Increased connective tissue (HP:0009025)4.12693085
21Abnormality of the left ventricular outflow tract (HP:0011103)4.07126071
22Subaortic stenosis (HP:0001682)4.07126071
23Abnormality of secondary sexual hair (HP:0009888)4.05675900
24Abnormality of the axillary hair (HP:0100134)4.05675900
25Rimmed vacuoles (HP:0003805)4.02079735
26Muscle stiffness (HP:0003552)4.01519051
27Difficulty running (HP:0009046)3.91787386
28Obstructive sleep apnea (HP:0002870)3.84172509
29Deformed tarsal bones (HP:0008119)3.83821367
30Increased variability in muscle fiber diameter (HP:0003557)3.81752770
31Distal lower limb muscle weakness (HP:0009053)3.72579343
32Abnormal ciliary motility (HP:0012262)3.70896371
33Absent phalangeal crease (HP:0006109)3.57633283
34Asymmetric septal hypertrophy (HP:0001670)3.54624489
35Septo-optic dysplasia (HP:0100842)3.52552774
36Thyroid-stimulating hormone excess (HP:0002925)3.52012442
37Dynein arm defect of respiratory motile cilia (HP:0012255)3.47776208
38Absent/shortened dynein arms (HP:0200106)3.47776208
39Split foot (HP:0001839)3.38064622
40Attenuation of retinal blood vessels (HP:0007843)3.37535489
41Myotonia (HP:0002486)3.31912204
42Parakeratosis (HP:0001036)3.30777603
43Malignant hyperthermia (HP:0002047)3.28968235
44Frequent falls (HP:0002359)3.27157639
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.26933248
46Joint hemorrhage (HP:0005261)3.20904520
47Abnormal respiratory motile cilium physiology (HP:0012261)3.19165675
48Areflexia of lower limbs (HP:0002522)3.18973839
49Absent septum pellucidum (HP:0001331)3.09257767
50Chronic obstructive pulmonary disease (HP:0006510)3.07272380
51Obstructive lung disease (HP:0006536)3.07272380
52Optic nerve hypoplasia (HP:0000609)2.98264744
53Abnormal finger flexion creases (HP:0006143)2.96288663
54Abnormal respiratory motile cilium morphology (HP:0005938)2.94948706
55Abnormal respiratory epithelium morphology (HP:0012253)2.94948706
56Nonprogressive disorder (HP:0003680)2.94721564
57Abnormality of the septum pellucidum (HP:0007375)2.94566853
58Sudden death (HP:0001699)2.93261124
59Slender build (HP:0001533)2.92428888
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.89007738
61Agammaglobulinemia (HP:0004432)2.85241534
62EMG: neuropathic changes (HP:0003445)2.83174647
63Generalized muscle weakness (HP:0003324)2.82466171
64Mildly elevated creatine phosphokinase (HP:0008180)2.80891896
65Bulbar palsy (HP:0001283)2.76351648
66Concave nail (HP:0001598)2.73487823
67Distal lower limb amyotrophy (HP:0008944)2.71591168
68Abnormality of the calcaneus (HP:0008364)2.58508419
69Progressive muscle weakness (HP:0003323)2.57756230
70Spinal rigidity (HP:0003306)2.56212385
71Stomatitis (HP:0010280)2.53241347
72Short tibia (HP:0005736)2.52396691
73Weak cry (HP:0001612)2.51155984
74Optic disc pallor (HP:0000543)2.50226884
75Menorrhagia (HP:0000132)2.47767672
76Bundle branch block (HP:0011710)2.47608295
77Muscle fiber inclusion bodies (HP:0100299)2.44831966
78Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44262288
79Aplasia cutis congenita (HP:0001057)2.42787694
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.39368344
81Prolonged partial thromboplastin time (HP:0003645)2.37774271
82Supernumerary spleens (HP:0009799)2.35486365
83Scapular winging (HP:0003691)2.35481024
84Laryngomalacia (HP:0001601)2.34275281
85Reticulocytopenia (HP:0001896)2.33630397
86Limb-girdle muscle atrophy (HP:0003797)2.32921959
87Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.32784205
88Dilated cardiomyopathy (HP:0001644)2.32127580
89Nemaline bodies (HP:0003798)2.29207124
90Ventricular tachycardia (HP:0004756)2.28135244
91Aplasia/Hypoplasia of the tibia (HP:0005772)2.27689980
92Gowers sign (HP:0003391)2.26829594
93Fetal akinesia sequence (HP:0001989)2.25928200
94Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23969669
95Difficulty climbing stairs (HP:0003551)2.21516407
96Abnormality of the neuromuscular junction (HP:0003398)2.21509075
97Fatigable weakness (HP:0003473)2.21509075
98Overfolded helix (HP:0000396)2.21406538
99Type I transferrin isoform profile (HP:0003642)2.20802663
100Ragged-red muscle fibers (HP:0003200)2.16052982
101Patchy hypopigmentation of hair (HP:0011365)2.15465698
102Sleep apnea (HP:0010535)2.14391607
103Conical tooth (HP:0000698)2.14360626
104Waddling gait (HP:0002515)2.11995778
105Macrocytic anemia (HP:0001972)2.11671838
106Muscle hypertrophy of the lower extremities (HP:0008968)2.11222177
107White forelock (HP:0002211)2.11021715
108Hip contracture (HP:0003273)2.09788314
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07374100
110Abnormality of cells of the erythroid lineage (HP:0012130)2.07360267
111Decreased central vision (HP:0007663)2.06927385
112Atelectasis (HP:0100750)2.06692816
113Hypoplasia of the radius (HP:0002984)2.05804503
114Reduced antithrombin III activity (HP:0001976)2.05232229
115Nasolacrimal duct obstruction (HP:0000579)2.03802286
116Meningitis (HP:0001287)2.03239051
117Paralysis (HP:0003470)2.02582093
118Lipoatrophy (HP:0100578)2.02425239
119Rhinitis (HP:0012384)2.02054817
120Alacrima (HP:0000522)2.01253779
121Muscular dystrophy (HP:0003560)2.01049866
122Hyperkalemia (HP:0002153)1.99213387
123Craniofacial hyperostosis (HP:0004493)1.97589834
124Abnormality of the foot musculature (HP:0001436)1.97056676
125Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96779923
126Lower limb amyotrophy (HP:0007210)1.96354059
127Pallor (HP:0000980)1.96013264
128Renal agenesis (HP:0000104)1.93598814
129Abnormal number of erythroid precursors (HP:0012131)1.92708094
130Submucous cleft hard palate (HP:0000176)1.92149670
131Hypophosphatemic rickets (HP:0004912)1.92023510
132Round ear (HP:0100830)1.91539560
133Hypoplasia of the ulna (HP:0003022)1.86603916
134Exercise intolerance (HP:0003546)1.86062747
135Seborrheic dermatitis (HP:0001051)1.85778060
136Foot dorsiflexor weakness (HP:0009027)1.85581841
137Popliteal pterygium (HP:0009756)1.85013983
138Amelogenesis imperfecta (HP:0000705)1.85013933
139Abnormally folded helix (HP:0008544)1.84752016
140Aplasia/hypoplasia of the uterus (HP:0008684)1.84176380
141Abnormality of the shoulder girdle musculature (HP:0001435)1.82583663
142Abnormality of magnesium homeostasis (HP:0004921)1.82092585
143Esotropia (HP:0000565)1.81879145
144Chin dimple (HP:0010751)1.81674034
145Partial duplication of thumb phalanx (HP:0009944)1.80151920
146Fibular aplasia (HP:0002990)1.79011383
147Increased hepatocellular lipid droplets (HP:0006565)1.78428959
148Proximal amyotrophy (HP:0007126)1.78335540
149Asplenia (HP:0001746)1.77989754
150Respiratory insufficiency due to muscle weakness (HP:0002747)1.77985089
151Partial duplication of the phalanx of hand (HP:0009999)1.77157958
152Peripheral hypomyelination (HP:0007182)1.77039866
153Hypothermia (HP:0002045)1.76127074
154Severe visual impairment (HP:0001141)1.76004447
155Decreased lacrimation (HP:0000633)1.75233321
156Morphological abnormality of the middle ear (HP:0008609)1.74888064
157Abnormality of the pulmonary veins (HP:0011718)1.73394693
158Pulmonary artery stenosis (HP:0004415)1.72073078
159Neonatal respiratory distress (HP:0002643)1.72055335
160Hypertensive crisis (HP:0100735)1.71989390
161Abnormality of the musculature of the pelvis (HP:0001469)1.71891637
162Abnormality of the hip-girdle musculature (HP:0001445)1.71891637
163Pelvic girdle muscle weakness (HP:0003749)1.71409594
164Abnormality of the phalanges of the 2nd finger (HP:0009541)1.70914294
165Absent speech (HP:0001344)1.70714406
166Facial diplegia (HP:0001349)1.68832084
167Limb-girdle muscle weakness (HP:0003325)1.67203287
168Shoulder girdle muscle weakness (HP:0003547)1.66447291
169Stage 5 chronic kidney disease (HP:0003774)1.66373036
170Anomalous pulmonary venous return (HP:0010772)1.65565752
171Metatarsus adductus (HP:0001840)1.65381905
172Aplasia/Hypoplasia of the ulna (HP:0006495)1.65241658
173Recurrent cutaneous fungal infections (HP:0011370)1.64564028
174Chronic mucocutaneous candidiasis (HP:0002728)1.64564028
175Focal motor seizures (HP:0011153)1.64140234
176Heart block (HP:0012722)1.63254193
177Increased intramyocellular lipid droplets (HP:0012240)1.62492335
178Abnormal atrioventricular conduction (HP:0005150)1.58964305
179Increased muscle lipid content (HP:0009058)1.55203515
180Muscle fiber atrophy (HP:0100295)1.54611251
181Type 2 muscle fiber atrophy (HP:0003554)1.53616379
182Ulnar deviation of finger (HP:0009465)1.53607020
183Easy fatigability (HP:0003388)1.50706630
184Achilles tendon contracture (HP:0001771)1.49945718
185Ventricular arrhythmia (HP:0004308)1.49797185
186Congenital hip dislocation (HP:0001374)1.48494634
187Long clavicles (HP:0000890)1.46127564
188Generalized amyotrophy (HP:0003700)1.40739303
189Stridor (HP:0010307)1.40374183
190Fatigue (HP:0012378)1.31219134
191Abnormality of the Achilles tendon (HP:0005109)1.30205054
192Limited hip movement (HP:0008800)1.29435803
193Short palpebral fissure (HP:0012745)1.28881097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.25053394
2TTN6.35087922
3MKNK25.76438370
4BLK3.93573336
5TNIK3.68881976
6MKNK13.34922656
7TLK13.01796547
8MAP2K32.70514677
9PHKG12.45382983
10PHKG22.45382983
11FES2.33746516
12MUSK2.19746817
13MAPK122.07269232
14STK161.94157611
15NLK1.89815666
16IRAK31.83728430
17IRAK41.82605875
18IRAK11.69902305
19NME21.65410796
20CLK11.62904224
21IRAK21.61082444
22MAP3K71.58237320
23PINK11.48322104
24PRKD21.31601731
25MAPKAPK31.30441146
26PKN11.29117243
27YES11.28385396
28PRPF4B1.27141184
29TNK21.21438176
30MOS1.19586232
31MAP2K41.14409944
32MAPK151.12276632
33TRPM71.09791964
34PIK3CG1.06170602
35MAP3K131.05255256
36EEF2K1.05069193
37EIF2AK21.02572034
38STK390.99988387
39TAOK20.98974259
40TRIB30.98417063
41CDK190.95921764
42MAP3K140.95690763
43CSK0.94598609
44PIM20.94589478
45FGR0.92949105
46LIMK10.91609642
47PAK20.91071179
48OBSCN0.88131412
49FER0.87942177
50MAP2K60.85857204
51DYRK1B0.85612232
52SRPK10.84482835
53KSR20.83059585
54ERN10.80876835
55GRK70.80296685
56MST40.77616144
57MAPK70.77551622
58ICK0.76556537
59BMPR1B0.76332234
60PBK0.75204551
61PRKAA20.74784930
62CCNB10.74704604
63BCKDK0.73807293
64NEK10.72923283
65RIPK10.71801774
66GRK10.71175643
67MAP3K110.69743306
68ADRBK20.68672198
69ARAF0.67677539
70DYRK1A0.67109065
71TAOK30.66260659
72CDK30.65553278
73KIT0.64266726
74TXK0.63933028
75IKBKE0.63880713
76OXSR10.62280950
77CAMK2B0.60856163
78RPS6KA50.60412017
79NME10.59981881
80MAPK110.59314436
81TEC0.59230660
82PDK20.58196624
83EPHB10.57983864
84SIK10.57128402
85MAP2K20.54842142
86DYRK20.54824688
87RIPK40.54315847
88MAP3K30.53706599
89PRKG10.53383392
90CSNK1G10.53018275
91ZAP700.52471018
92AKT20.52112473
93CAMK40.51944279
94HIPK20.51860753
95PAK10.51055457
96INSRR0.50994725
97PRKAA10.50828322
98NEK90.50058615
99MAPKAPK50.48932925
100UHMK10.47693552
101LYN0.45513705
102SGK30.45466129
103MAPK130.45056862
104IKBKB0.44855097
105HCK0.44013784
106VRK10.43688016
107LCK0.43667502
108EIF2AK30.43186259
109BRAF0.42255934
110MAP2K10.41975581
111CAMK10.41495993
112TYK20.40493931
113PNCK0.39428028
114NEK60.39148884
115CAMK2A0.38875211
116DMPK0.38712516
117TAOK10.38575785
118BMX0.36016479
119MAP3K10.35863600
120TIE10.35376264
121PDPK10.35198348
122EPHB20.35028745
123DYRK30.31908814
124RAF10.30873720
125STK110.30731680
126CAMK2D0.30601033
127CAMK2G0.30565719
128BMPR20.30109761
129RPS6KC10.29661759
130RPS6KL10.29661759
131MARK20.29139699
132SIK20.29015320
133PRKD10.28594042
134ROCK10.27961253
135ROCK20.27397219
136GSK3A0.26830684
137TGFBR20.26784606
138BTK0.26635744
139MAPK40.25610260
140TBK10.25551154
141PRKCQ0.25538253
142MARK10.25415311
143MARK30.23786760
144ABL10.23728150
145CDC42BPA0.23704079
146MAP2K70.22904349
147LATS20.20755205
148PDK10.20561586
149CSNK1A1L0.20430283
150RPS6KA60.20169278
151CSNK1D0.20098473
152NUAK10.19825199
153ERBB30.19656682
154SGK20.19028451
155RPS6KA10.18936087
156MAP3K60.17258702
157PRKG20.16738550
158MAPK100.16618874
159PRKACA0.16301171
160MTOR0.16259030
161SYK0.15796262
162RPS6KA20.15481657
163KSR10.15090934
164ABL20.14626678
165SGK10.13101227
166MAP3K80.12045175

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.05674160
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.83533034
3Dilated cardiomyopathy_Homo sapiens_hsa054143.77556226
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.53944950
5Ribosome_Homo sapiens_hsa030103.45204064
6Pentose phosphate pathway_Homo sapiens_hsa000302.71538642
7Carbon metabolism_Homo sapiens_hsa012002.42488220
8Phototransduction_Homo sapiens_hsa047442.41472483
9Protein export_Homo sapiens_hsa030602.30521374
10Insulin signaling pathway_Homo sapiens_hsa049102.30342467
11Glucagon signaling pathway_Homo sapiens_hsa049222.21290887
12Fructose and mannose metabolism_Homo sapiens_hsa000512.14365580
13Circadian rhythm_Homo sapiens_hsa047102.10145858
14Fanconi anemia pathway_Homo sapiens_hsa034602.10043375
15Other glycan degradation_Homo sapiens_hsa005112.03588547
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91816173
17Arginine and proline metabolism_Homo sapiens_hsa003301.90801016
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.86840365
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83294638
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.80064557
21Sphingolipid metabolism_Homo sapiens_hsa006001.77410301
22Insulin resistance_Homo sapiens_hsa049311.72510896
23Oxytocin signaling pathway_Homo sapiens_hsa049211.71948443
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.71274025
25Ether lipid metabolism_Homo sapiens_hsa005651.60544312
26Arginine biosynthesis_Homo sapiens_hsa002201.58082411
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54873939
28Homologous recombination_Homo sapiens_hsa034401.53878639
29Malaria_Homo sapiens_hsa051441.53626701
30Biosynthesis of amino acids_Homo sapiens_hsa012301.52192768
31Asthma_Homo sapiens_hsa053101.50766675
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50730199
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.47976249
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.47755109
35Axon guidance_Homo sapiens_hsa043601.46659862
36Arachidonic acid metabolism_Homo sapiens_hsa005901.46457250
37Graft-versus-host disease_Homo sapiens_hsa053321.45597194
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43178875
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37813077
40Long-term depression_Homo sapiens_hsa047301.36786043
41Nicotine addiction_Homo sapiens_hsa050331.34463711
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33647069
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33553214
44Autoimmune thyroid disease_Homo sapiens_hsa053201.33127055
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.32752129
46Viral myocarditis_Homo sapiens_hsa054161.29079880
47AMPK signaling pathway_Homo sapiens_hsa041521.27971416
48Pyruvate metabolism_Homo sapiens_hsa006201.25563243
49Galactose metabolism_Homo sapiens_hsa000521.25457069
50Hematopoietic cell lineage_Homo sapiens_hsa046401.24304832
51Allograft rejection_Homo sapiens_hsa053301.24224196
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18866034
53Oxidative phosphorylation_Homo sapiens_hsa001901.16627942
54Spliceosome_Homo sapiens_hsa030401.11158968
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09307835
56RNA polymerase_Homo sapiens_hsa030201.08988929
57Starch and sucrose metabolism_Homo sapiens_hsa005001.08291298
58Primary immunodeficiency_Homo sapiens_hsa053400.98818882
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97974331
60Linoleic acid metabolism_Homo sapiens_hsa005910.97160796
61Leishmaniasis_Homo sapiens_hsa051400.96222185
62Melanogenesis_Homo sapiens_hsa049160.95470247
63Basal cell carcinoma_Homo sapiens_hsa052170.95233473
64Serotonergic synapse_Homo sapiens_hsa047260.94922665
65Staphylococcus aureus infection_Homo sapiens_hsa051500.94640611
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91029934
67Taste transduction_Homo sapiens_hsa047420.89779001
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.85522536
69Wnt signaling pathway_Homo sapiens_hsa043100.85459309
70Calcium signaling pathway_Homo sapiens_hsa040200.84750675
71Osteoclast differentiation_Homo sapiens_hsa043800.82402731
72Alzheimers disease_Homo sapiens_hsa050100.82131061
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82113425
74Fatty acid degradation_Homo sapiens_hsa000710.82063003
75VEGF signaling pathway_Homo sapiens_hsa043700.80954714
76Measles_Homo sapiens_hsa051620.80553883
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79075759
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77641737
79Basal transcription factors_Homo sapiens_hsa030220.77390299
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76558152
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75659209
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.74130333
83Focal adhesion_Homo sapiens_hsa045100.73963178
84Rheumatoid arthritis_Homo sapiens_hsa053230.73180026
85Ras signaling pathway_Homo sapiens_hsa040140.73060380
86T cell receptor signaling pathway_Homo sapiens_hsa046600.72839148
87Glutamatergic synapse_Homo sapiens_hsa047240.72770933
88Melanoma_Homo sapiens_hsa052180.69970826
89Propanoate metabolism_Homo sapiens_hsa006400.69464669
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68629422
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68535892
92African trypanosomiasis_Homo sapiens_hsa051430.67490086
93Pertussis_Homo sapiens_hsa051330.67251322
94Long-term potentiation_Homo sapiens_hsa047200.67203190
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66589763
96B cell receptor signaling pathway_Homo sapiens_hsa046620.65735064
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65162822
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63667316
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63407706
100FoxO signaling pathway_Homo sapiens_hsa040680.62882040
101MicroRNAs in cancer_Homo sapiens_hsa052060.62270358
102Morphine addiction_Homo sapiens_hsa050320.62022390
103Gastric acid secretion_Homo sapiens_hsa049710.61267240
104Huntingtons disease_Homo sapiens_hsa050160.61139649
105Fatty acid metabolism_Homo sapiens_hsa012120.60241392
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.59836974
107Cardiac muscle contraction_Homo sapiens_hsa042600.59818660
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59782559
109Phenylalanine metabolism_Homo sapiens_hsa003600.59568479
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59280244
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59260923
112Fatty acid elongation_Homo sapiens_hsa000620.59121162
113Sulfur relay system_Homo sapiens_hsa041220.58995015
114MAPK signaling pathway_Homo sapiens_hsa040100.58032040
115Prostate cancer_Homo sapiens_hsa052150.57780683
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56936568
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.56883471
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56867396
119HIF-1 signaling pathway_Homo sapiens_hsa040660.56349454
120Amoebiasis_Homo sapiens_hsa051460.56088288
121Acute myeloid leukemia_Homo sapiens_hsa052210.55366353
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54904962
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52751333
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52664778
125Parkinsons disease_Homo sapiens_hsa050120.52512700
126Tight junction_Homo sapiens_hsa045300.51628956
127ECM-receptor interaction_Homo sapiens_hsa045120.51394817
128Phagosome_Homo sapiens_hsa041450.50721349
129Renal cell carcinoma_Homo sapiens_hsa052110.49589784
130Salivary secretion_Homo sapiens_hsa049700.48956500
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48465637
132Hedgehog signaling pathway_Homo sapiens_hsa043400.47907907
133Nitrogen metabolism_Homo sapiens_hsa009100.47722129
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.46670975
135Purine metabolism_Homo sapiens_hsa002300.46650446
136Bladder cancer_Homo sapiens_hsa052190.46606832
137Nucleotide excision repair_Homo sapiens_hsa034200.46162866
138Salmonella infection_Homo sapiens_hsa051320.45643039
139ErbB signaling pathway_Homo sapiens_hsa040120.45621556
140DNA replication_Homo sapiens_hsa030300.45543863
141Dorso-ventral axis formation_Homo sapiens_hsa043200.45481326
142Platelet activation_Homo sapiens_hsa046110.44778592
143Pyrimidine metabolism_Homo sapiens_hsa002400.44627457
144Thyroid cancer_Homo sapiens_hsa052160.44498100
145Chemokine signaling pathway_Homo sapiens_hsa040620.44466180
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44378394
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.43977742
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.43781022
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43545446
150GnRH signaling pathway_Homo sapiens_hsa049120.42861239
151Tuberculosis_Homo sapiens_hsa051520.42812080
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.42672030
153Non-small cell lung cancer_Homo sapiens_hsa052230.42195457
154Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38004381
155Renin secretion_Homo sapiens_hsa049240.34157646
156mTOR signaling pathway_Homo sapiens_hsa041500.34030125
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31446928
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31093700
159Glioma_Homo sapiens_hsa052140.30420188
160Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30306001
161Legionellosis_Homo sapiens_hsa051340.27392919
162Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23230137
163Regulation of autophagy_Homo sapiens_hsa041400.22847760
164Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22583362
165Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20100207
166Chronic myeloid leukemia_Homo sapiens_hsa052200.17616673
167Endometrial cancer_Homo sapiens_hsa052130.12946677
168PPAR signaling pathway_Homo sapiens_hsa033200.12070027
169Aldosterone synthesis and secretion_Homo sapiens_hsa049250.12061300
170Proteoglycans in cancer_Homo sapiens_hsa052050.09889996

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