FHL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.87884344
2spermatid development (GO:0007286)9.87758262
3axonemal dynein complex assembly (GO:0070286)9.70982725
4motile cilium assembly (GO:0044458)9.23691371
5cilium or flagellum-dependent cell motility (GO:0001539)8.77051957
6regulation of cilium movement (GO:0003352)8.53860857
7cilium movement (GO:0003341)8.13642066
8single fertilization (GO:0007338)7.57364521
9sperm capacitation (GO:0048240)7.44073768
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.38348554
11negative regulation of inclusion body assembly (GO:0090084)7.14377477
12synaptonemal complex organization (GO:0070193)7.10103707
13male meiosis (GO:0007140)7.05392120
14synaptonemal complex assembly (GO:0007130)7.00881239
15spermatogenesis (GO:0007283)6.66422266
16male gamete generation (GO:0048232)6.63924755
17piRNA metabolic process (GO:0034587)6.63803621
18organic cation transport (GO:0015695)6.41940398
19fertilization (GO:0009566)6.35384407
20microtubule depolymerization (GO:0007019)6.30469624
21gamete generation (GO:0007276)6.11069812
22actin-myosin filament sliding (GO:0033275)6.10011703
23muscle filament sliding (GO:0030049)6.10011703
24spermatid nucleus differentiation (GO:0007289)6.05455982
25sarcoplasmic reticulum calcium ion transport (GO:0070296)5.95853587
26regulation of inclusion body assembly (GO:0090083)5.92220411
27calcium ion-dependent exocytosis (GO:0017156)5.64816667
28germ cell development (GO:0007281)5.45244667
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.41414503
30sexual reproduction (GO:0019953)5.21685450
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.16741718
32glycerol ether metabolic process (GO:0006662)5.15833799
33actin-mediated cell contraction (GO:0070252)5.15235341
34cell recognition (GO:0008037)5.11014666
35ventricular system development (GO:0021591)5.10548581
36chromosome condensation (GO:0030261)5.04756299
37myofibril assembly (GO:0030239)4.98329204
38regulation of microtubule-based movement (GO:0060632)4.97965893
39regulation of skeletal muscle contraction (GO:0014819)4.93265776
40microtubule severing (GO:0051013)4.90058549
41multicellular organismal reproductive process (GO:0048609)4.82171680
42ether metabolic process (GO:0018904)4.76535484
43chromosome organization involved in meiosis (GO:0070192)4.75790477
44DNA packaging (GO:0006323)4.72372691
45regulation of relaxation of muscle (GO:1901077)4.71349335
46single strand break repair (GO:0000012)4.66949695
47regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.60769435
48skeletal muscle contraction (GO:0003009)4.55472263
49male meiosis I (GO:0007141)4.51836157
50cardiac myofibril assembly (GO:0055003)4.43523213
51seminiferous tubule development (GO:0072520)4.38593008
52DNA methylation involved in gamete generation (GO:0043046)4.27657690
53response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.18640826
54striated muscle contraction (GO:0006941)4.13555958
55left/right pattern formation (GO:0060972)4.12222595
56meiotic nuclear division (GO:0007126)4.11885170
57peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.03728275
58actin filament-based movement (GO:0030048)3.96532597
59chaperone-mediated protein complex assembly (GO:0051131)3.89239397
60sarcomere organization (GO:0045214)3.88413583
61multicellular organismal development (GO:0007275)3.87939125
62regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.85703092
63regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.80541515
64protein K11-linked deubiquitination (GO:0035871)3.76956748
65cardiac muscle hypertrophy (GO:0003300)3.75498555
66cardiac muscle contraction (GO:0060048)3.74219915
67regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.73485362
68genitalia morphogenesis (GO:0035112)3.73456096
69response to inactivity (GO:0014854)3.72599763
70striated muscle hypertrophy (GO:0014897)3.71364946
71muscle contraction (GO:0006936)3.68356740
72monoubiquitinated protein deubiquitination (GO:0035520)3.63934367
73cellular response to epinephrine stimulus (GO:0071872)3.61400610
74meiosis I (GO:0007127)3.55387045
75response to epinephrine (GO:0071871)3.53228716
76regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.52185498
77regulation of cell communication by electrical coupling (GO:0010649)3.52128517
78positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.49992324
79protein polyglutamylation (GO:0018095)3.49526627
80creatine metabolic process (GO:0006600)3.48052957
81sequestering of actin monomers (GO:0042989)3.47301414
82cGMP-mediated signaling (GO:0019934)3.45323966
83regulation of actin filament-based movement (GO:1903115)3.44341411
84muscle hypertrophy (GO:0014896)3.42731638
85actomyosin structure organization (GO:0031032)3.42489492
86muscle system process (GO:0003012)3.40301985
87skeletal muscle fiber development (GO:0048741)3.38597476
88myotube cell development (GO:0014904)3.34456022
89skeletal muscle adaptation (GO:0043501)3.34359863
90positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.34260471
91metanephric nephron tubule development (GO:0072234)3.32679022
92metanephric tubule development (GO:0072170)3.32679022
93regulation of sequestering of triglyceride (GO:0010889)3.29406498
94carnitine shuttle (GO:0006853)3.29076414
95glycolytic process (GO:0006096)3.27241407
96protein refolding (GO:0042026)3.27139113
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27001269
98regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.25601703
99microtubule polymerization or depolymerization (GO:0031109)3.22597690
100NADH metabolic process (GO:0006734)3.21573524
101metanephric nephron epithelium development (GO:0072243)3.21116942
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19252143
103response to muscle activity (GO:0014850)3.16605824
104meiotic cell cycle (GO:0051321)3.16570361
105relaxation of muscle (GO:0090075)3.13924703
106nucleus organization (GO:0006997)3.12635287
107regulation of spindle checkpoint (GO:0090231)3.12494170
108amino-acid betaine transport (GO:0015838)3.11292364
109carnitine transport (GO:0015879)3.11292364
110striated muscle adaptation (GO:0014888)3.08521083
111positive regulation of macrophage activation (GO:0043032)3.02608902
112cardiac muscle adaptation (GO:0014887)3.02554244
113cardiac muscle hypertrophy in response to stress (GO:0014898)3.02554244
114muscle hypertrophy in response to stress (GO:0003299)3.02554244
115fatty acid transmembrane transport (GO:1902001)3.01519108
116nucleoside diphosphate phosphorylation (GO:0006165)2.96780636
117polyol catabolic process (GO:0046174)2.96552940
118carnitine transmembrane transport (GO:1902603)2.96132922
119metanephric epithelium development (GO:0072207)2.96013344
120interferon-gamma secretion (GO:0072643)2.95620373
121alditol metabolic process (GO:0019400)2.90737732
122protein localization to cilium (GO:0061512)2.88711980
123regulation of striated muscle contraction (GO:0006942)2.88411007
124GTP biosynthetic process (GO:0006183)2.84799600
125relaxation of cardiac muscle (GO:0055119)2.84389109
126mitotic sister chromatid cohesion (GO:0007064)2.83746061
127muscle fiber development (GO:0048747)2.81466167
128cilium organization (GO:0044782)2.79917262
129regulation of calcium ion transmembrane transporter activity (GO:1901019)2.77707597
130regulation of calcium ion transmembrane transport (GO:1903169)2.77707597
131surfactant homeostasis (GO:0043129)2.77154938
132RNA localization (GO:0006403)2.76920446
133synapsis (GO:0007129)2.74021312
134myotube differentiation (GO:0014902)2.73187158
135chemical homeostasis within a tissue (GO:0048875)2.72592001
136metanephric mesenchyme development (GO:0072075)2.70853241
137chromatin silencing (GO:0006342)2.70605128
138regulation of p38MAPK cascade (GO:1900744)2.70359429
139cellular potassium ion homeostasis (GO:0030007)2.70343542
140regulation of the force of heart contraction (GO:0002026)2.70206497
141regulation of phosphoprotein phosphatase activity (GO:0043666)2.69974070
142regulation of skeletal muscle cell differentiation (GO:2001014)2.69360157
143cellular component assembly involved in morphogenesis (GO:0010927)2.68925969
144cilium assembly (GO:0042384)2.68405825
145glycogen catabolic process (GO:0005980)2.68398783
146lactate metabolic process (GO:0006089)2.68123422
147polyamine biosynthetic process (GO:0006596)2.67492182
148meiotic cell cycle process (GO:1903046)2.67312097
149sodium ion export (GO:0071436)2.66689807
150microtubule-based movement (GO:0007018)2.66586161
151cellular sodium ion homeostasis (GO:0006883)2.65739582
152regulation of muscle system process (GO:0090257)2.65430526
153skeletal muscle tissue development (GO:0007519)2.64681680
154cell communication by electrical coupling (GO:0010644)2.60037886
155negative regulation of muscle contraction (GO:0045932)2.59866930
156kidney mesenchyme development (GO:0072074)2.59065629
157myoblast fusion (GO:0007520)2.58245834
158growth hormone receptor signaling pathway (GO:0060396)2.57916374
159cilium morphogenesis (GO:0060271)2.57030335
160muscle adaptation (GO:0043500)2.56119753
161membrane depolarization during action potential (GO:0086010)2.55736309
162regulation of muscle adaptation (GO:0043502)2.55356241
163muscle organ development (GO:0007517)2.55058633
164RNA destabilization (GO:0050779)2.54407755
165negative regulation of Rho protein signal transduction (GO:0035024)2.53733494
166intraciliary transport (GO:0042073)2.53347627
167muscle structure development (GO:0061061)2.53100610
168UTP biosynthetic process (GO:0006228)2.52812205
169endocrine hormone secretion (GO:0060986)2.52723250
170glucan catabolic process (GO:0009251)2.50622693
171peripheral nervous system axon ensheathment (GO:0032292)2.50128335
172myelination in peripheral nervous system (GO:0022011)2.50128335
173regulation of membrane repolarization (GO:0060306)2.50080792
174negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49934480
175plasma membrane repair (GO:0001778)2.48723763
176regulation of cilium assembly (GO:1902017)2.48383212
177negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.48258559
178glycerol metabolic process (GO:0006071)2.45298485
179centriole assembly (GO:0098534)2.44893827
180axoneme assembly (GO:0035082)2.41431439
181negative regulation of organelle assembly (GO:1902116)2.40486044
182gene silencing by RNA (GO:0031047)2.39698884
183sperm motility (GO:0030317)14.4205048
184cell wall macromolecule catabolic process (GO:0016998)13.8920779
185cell wall macromolecule metabolic process (GO:0044036)13.8920779
186fusion of sperm to egg plasma membrane (GO:0007342)13.4341820
187acrosome reaction (GO:0007340)12.1742642
188acrosome assembly (GO:0001675)11.9003467
189sperm-egg recognition (GO:0035036)11.7361864
190multicellular organism reproduction (GO:0032504)11.2108402
191binding of sperm to zona pellucida (GO:0007339)10.6893078
192cell-cell recognition (GO:0009988)10.5130093
193plasma membrane fusion (GO:0045026)10.2483064
194epithelial cilium movement (GO:0003351)10.0642400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.84789407
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.05935896
3EZH2_22144423_ChIP-Seq_EOC_Human3.95123222
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.52570476
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.19285178
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.91551873
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.81390120
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65157467
9VDR_22108803_ChIP-Seq_LS180_Human2.41717506
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.35306754
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.21856378
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14766271
13GBX2_23144817_ChIP-Seq_PC3_Human2.10473326
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.09869401
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.05636242
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05477477
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04670088
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.03767852
19ZNF274_21170338_ChIP-Seq_K562_Hela2.00952179
20KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.96060940
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89360559
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85072425
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.83639005
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.80796232
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80726941
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79427556
27DROSHA_22980978_ChIP-Seq_HELA_Human1.78607296
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.78212048
29STAT1_17558387_ChIP-Seq_HELA_Human1.74874601
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71230582
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71144818
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.71007778
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.66438688
34KDM2B_26808549_Chip-Seq_REH_Human1.65434905
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.64112558
36AR_21572438_ChIP-Seq_LNCaP_Human1.62995683
37FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61889113
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.61568622
39TBX20_22328084_ChIP-Seq_HEART_Mouse1.61568622
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61329503
41GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.59938097
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59302565
43SOX2_22085726_ChIP-Seq_NPCs_Mouse1.55926414
44TAL1_26923725_Chip-Seq_HPCs_Mouse1.55381561
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52395605
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51948231
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50496862
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50069468
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47884185
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.47575521
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47562972
52CBP_20019798_ChIP-Seq_JUKART_Human1.47562972
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47295367
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47295367
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.46782385
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46031009
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45557736
58SMAD4_21799915_ChIP-Seq_A2780_Human1.44930826
59GATA1_22025678_ChIP-Seq_K562_Human1.44569802
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41884015
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.40172587
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40113767
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36965817
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36204415
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33209179
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.31116335
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30470602
68LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29787691
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29692628
70GATA3_21867929_ChIP-Seq_TH1_Mouse1.29513443
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.29231043
72P53_21459846_ChIP-Seq_SAOS-2_Human1.28862927
73* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28746161
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27400435
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26988799
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25949502
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.25913177
78CJUN_26792858_Chip-Seq_BT549_Human1.25818594
79FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25780279
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.25079646
81REST_21632747_ChIP-Seq_MESCs_Mouse1.23474607
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22859405
83TAF15_26573619_Chip-Seq_HEK293_Human1.22855200
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.22505003
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.22092235
86CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21189558
87GF1_26923725_Chip-Seq_HPCs_Mouse1.21011605
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.20762625
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20229727
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20229727
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19187318
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18402807
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.17627911
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17325914
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15193646
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15029437
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.14725987
98RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14357839
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14331192
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13946334
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13244367
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12821150
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12749696
104RNF2_27304074_Chip-Seq_ESCs_Mouse1.12097581
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12011840
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11634081
107P53_22387025_ChIP-Seq_ESCs_Mouse1.11598441
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.11374027
109SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10856217
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.10626033
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.10132663
112AR_25329375_ChIP-Seq_VCAP_Human1.09521495
113JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09488620
114CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09351372
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09138225
116CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08948235
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08895273
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08877848
119WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08799884
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.08644261
121RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07679978
122NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07503730
123SPI1_26923725_Chip-Seq_HPCs_Mouse1.07445323
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07405297
125TCF4_18268006_ChIP-ChIP_LS174T_Human1.07276893
126AHR_22903824_ChIP-Seq_MCF-7_Human1.06417714
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06245623
128ESET_19884257_ChIP-Seq_ESCs_Mouse1.06013545
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05943669
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05671469
131* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04349914
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.03781777
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03100040
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02654096
135SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02599660
136P300_18555785_Chip-Seq_ESCs_Mouse1.02543586
137RXR_22108803_ChIP-Seq_LS180_Human1.02460853
138GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02047967
139SMAD4_21741376_ChIP-Seq_HESCs_Human1.01986847
140EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01912694
141ERG_20517297_ChIP-Seq_VCAP_Human1.01635977
142RNF2_27304074_Chip-Seq_NSC_Mouse1.00889530
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99916566
144KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99651738
145MYC_27129775_Chip-Seq_CORNEA_Mouse0.99513306
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99332000
147KLF4_18555785_Chip-Seq_ESCs_Mouse0.98581999
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98490421
149TP53_18474530_ChIP-ChIP_U2OS_Human0.98442337
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.98368822
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.97760904
152ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96687685
153* STAT3_23295773_ChIP-Seq_U87_Human0.96602256
154SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95731964
155CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95664163
156SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95174875
157SOX9_26525672_Chip-Seq_HEART_Mouse0.94082609
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.93934178
159RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93560785
160GF1B_26923725_Chip-Seq_HPCs_Mouse0.93512584
161EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93043858
162NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92795833
163RARA_24833708_ChIP-Seq_LIVER_Mouse0.92415580
164NFYB_21822215_ChIP-Seq_K562_Human0.92326025
165TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92285496
166* TCF4_23295773_ChIP-Seq_U87_Human0.91328913
167LXR_22158963_ChIP-Seq_LIVER_Mouse0.91113255
168LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90887189
169JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.90473417
170RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90453588
171RUNX_20019798_ChIP-Seq_JUKART_Human0.90336184
172TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90048511
173SOX2_18555785_Chip-Seq_ESCs_Mouse0.89880640
174* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89737481
175SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89544219
176STAT3_18555785_Chip-Seq_ESCs_Mouse0.89029170
177FUS_26573619_Chip-Seq_HEK293_Human0.87927319
178TRIM28_21343339_ChIP-Seq_HEK293_Human0.87398087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.03687042
2* MP0001929_abnormal_gametogenesis5.48041063
3MP0008877_abnormal_DNA_methylation3.91665009
4MP0000749_muscle_degeneration3.86288071
5* MP0002161_abnormal_fertility/fecundity3.29445562
6* MP0002210_abnormal_sex_determination3.20941182
7MP0005670_abnormal_white_adipose3.13489661
8MP0005275_abnormal_skin_tensile2.76404773
9* MP0001145_abnormal_male_reproductive2.73972922
10MP0005620_abnormal_muscle_contractility2.54423159
11* MP0000653_abnormal_sex_gland2.38186239
12MP0000759_abnormal_skeletal_muscle2.34306940
13MP0004215_abnormal_myocardial_fiber2.30893104
14MP0000747_muscle_weakness2.27117975
15MP0010368_abnormal_lymphatic_system2.24569696
16MP0006138_congestive_heart_failure2.19623448
17MP0005369_muscle_phenotype2.17699194
18MP0002653_abnormal_ependyma_morphology2.17515013
19MP0002332_abnormal_exercise_endurance2.11188828
20MP0004484_altered_response_of2.08006796
21MP0005410_abnormal_fertilization16.6974735
22MP0005330_cardiomyopathy1.91009653
23MP0002972_abnormal_cardiac_muscle1.84596809
24MP0000013_abnormal_adipose_tissue1.83936554
25MP0000750_abnormal_muscle_regeneration1.79377837
26MP0001879_abnormal_lymphatic_vessel1.74592289
27MP0005167_abnormal_blood-brain_barrier1.72390078
28MP0005623_abnormal_meninges_morphology1.66736052
29MP0002127_abnormal_cardiovascular_syste1.65172913
30MP0003828_pulmonary_edema1.64687651
31MP0002638_abnormal_pupillary_reflex1.52507031
32MP0002160_abnormal_reproductive_system1.47873333
33MP0008438_abnormal_cutaneous_collagen1.47347862
34MP0005385_cardiovascular_system_phenoty1.45560778
35MP0001544_abnormal_cardiovascular_syste1.45560778
36MP0003879_abnormal_hair_cell1.43027178
37MP0004510_myositis1.42376034
38MP0004270_analgesia1.39577491
39MP0004233_abnormal_muscle_weight1.39205762
40MP0009780_abnormal_chondrocyte_physiolo1.38259383
41MP0008775_abnormal_heart_ventricle1.35447254
42MP0003646_muscle_fatigue1.34835522
43MP0004085_abnormal_heartbeat1.32989090
44MP0000733_abnormal_muscle_development1.31528541
45MP0001958_emphysema1.29019471
46MP0002282_abnormal_trachea_morphology1.28696864
47MP0010630_abnormal_cardiac_muscle1.26815459
48MP0000003_abnormal_adipose_tissue1.24086736
49MP0005451_abnormal_body_composition1.22038738
50MP0005595_abnormal_vascular_smooth1.20472537
51MP0001765_abnormal_ion_homeostasis1.19795083
52MP0003137_abnormal_impulse_conducting1.17263170
53MP0005647_abnormal_sex_gland1.01789445
54MP0000230_abnormal_systemic_arterial0.99899723
55MP0008004_abnormal_stomach_pH0.96091890
56MP0005423_abnormal_somatic_nervous0.92183834
57MP0005535_abnormal_body_temperature0.87582047
58MP0001501_abnormal_sleep_pattern0.87464701
59MP0001486_abnormal_startle_reflex0.86955586
60MP0002272_abnormal_nervous_system0.86517262
61MP0001984_abnormal_olfaction0.86389795
62MP0005165_increased_susceptibility_to0.81139886
63MP0008058_abnormal_DNA_repair0.78625052
64MP0009046_muscle_twitch0.77603927
65MP0000343_altered_response_to0.77502869
66MP0005266_abnormal_metabolism0.76499979
67MP0010386_abnormal_urinary_bladder0.75614169
68MP0004036_abnormal_muscle_relaxation0.74986248
69MP0001440_abnormal_grooming_behavior0.74726749
70MP0005666_abnormal_adipose_tissue0.74143311
71MP0004272_abnormal_basement_membrane0.73983758
72MP0004782_abnormal_surfactant_physiolog0.72681154
73MP0005389_reproductive_system_phenotype0.72613596
74MP0000249_abnormal_blood_vessel0.72206468
75MP0002234_abnormal_pharynx_morphology0.69969702
76MP0003091_abnormal_cell_migration0.69031213
77MP0003115_abnormal_respiratory_system0.68867992
78MP0003690_abnormal_glial_cell0.67327387
79MP0002128_abnormal_blood_circulation0.66964457
80MP0008995_early_reproductive_senescence0.66313939
81MP0003011_delayed_dark_adaptation0.64564439
82MP0006276_abnormal_autonomic_nervous0.63674975
83MP0005334_abnormal_fat_pad0.63485647
84MP0005636_abnormal_mineral_homeostasis0.61372112
85MP0003868_abnormal_feces_composition0.60983356
86MP0003705_abnormal_hypodermis_morpholog0.60789690
87MP0001299_abnormal_eye_distance/0.60675188
88MP0002067_abnormal_sensory_capabilities0.58959301
89MP0005166_decreased_susceptibility_to0.58630277
90MP0003635_abnormal_synaptic_transmissio0.56566349
91MP0004185_abnormal_adipocyte_glucose0.56221873
92MP0002933_joint_inflammation0.55791945
93MP0003950_abnormal_plasma_membrane0.55231192
94MP0009278_abnormal_bone_marrow0.53269851
95MP0002928_abnormal_bile_duct0.52927489
96MP0003329_amyloid_beta_deposits0.51548261
97MP0002269_muscular_atrophy0.49117761
98MP0003699_abnormal_female_reproductive0.48611629
99MP0001324_abnormal_eye_pigmentation0.46113297
100MP0000569_abnormal_digit_pigmentation0.45350267
101MP0003878_abnormal_ear_physiology0.45136575
102MP0005377_hearing/vestibular/ear_phenot0.45136575
103MP0009115_abnormal_fat_cell0.45017924
104MP0001764_abnormal_homeostasis0.43891130
105MP0002295_abnormal_pulmonary_circulatio0.43410883
106MP0005397_hematopoietic_system_phenotyp0.42839582
107MP0001545_abnormal_hematopoietic_system0.42839582
108MP0002971_abnormal_brown_adipose0.42658522
109MP0000358_abnormal_cell_content/0.42119247
110MP0000534_abnormal_ureter_morphology0.41482375
111MP0001293_anophthalmia0.41440342
112MP0000751_myopathy0.40656829
113MP0004145_abnormal_muscle_electrophysio0.38573076
114MP0005253_abnormal_eye_physiology0.38111211
115MP0005551_abnormal_eye_electrophysiolog0.35566413
116MP0002736_abnormal_nociception_after0.35215859
117MP0006036_abnormal_mitochondrial_physio0.34469777
118MP0005375_adipose_tissue_phenotype0.30731348
119MP0003633_abnormal_nervous_system0.30475891
120MP0001119_abnormal_female_reproductive0.30412725
121MP0005391_vision/eye_phenotype0.29582500
122MP0010094_abnormal_chromosome_stability0.29394174
123MP0003279_aneurysm0.28405797
124MP0003942_abnormal_urinary_system0.28044676
125MP0002102_abnormal_ear_morphology0.28019761
126MP0004084_abnormal_cardiac_muscle0.27946721
127MP0004130_abnormal_muscle_cell0.26933578
128MP0000604_amyloidosis0.26670047
129MP0004019_abnormal_vitamin_homeostasis0.25046961
130MP0003948_abnormal_gas_homeostasis0.24295722
131MP0004133_heterotaxia0.23210385
132MP0001348_abnormal_lacrimal_gland0.22144868
133MP0000462_abnormal_digestive_system0.22126249
134MP0002139_abnormal_hepatobiliary_system0.21997885
135MP0002169_no_abnormal_phenotype0.20536876
136MP0004811_abnormal_neuron_physiology0.20461179
137MP0002873_normal_phenotype0.20270036
138MP0003631_nervous_system_phenotype0.20170911
139MP0001727_abnormal_embryo_implantation0.19760195
140MP0009697_abnormal_copulation0.18840239
141MP0003959_abnormal_lean_body0.18473344
142MP0003045_fibrosis0.17991506
143MP0008961_abnormal_basal_metabolism0.17526243
144MP0003861_abnormal_nervous_system0.17482798
145MP0002092_abnormal_eye_morphology0.17391497
146MP0002108_abnormal_muscle_morphology0.16929619
147MP0001661_extended_life_span0.16661576
148MP0004087_abnormal_muscle_fiber0.16045674
149MP0002152_abnormal_brain_morphology0.16015939
150MP0002009_preneoplasia0.15342765
151MP0002133_abnormal_respiratory_system0.15115005
152MP0005388_respiratory_system_phenotype0.15115005
153MP0005319_abnormal_enzyme/_coenzyme0.14918586
154MP0009250_abnormal_appendicular_skeleto0.14703254
155MP0001968_abnormal_touch/_nociception0.14629269
156MP0001730_embryonic_growth_arrest0.14390767
157MP0005503_abnormal_tendon_morphology0.14167089
158MP0002106_abnormal_muscle_physiology0.14127606
159MP0001270_distended_abdomen0.13952562
160MP0002693_abnormal_pancreas_physiology0.13789791
161MP0002118_abnormal_lipid_homeostasis0.13714514
162MP0004808_abnormal_hematopoietic_stem0.13593451
163MP0002837_dystrophic_cardiac_calcinosis0.13466956
164MP0008569_lethality_at_weaning0.13196485

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.37359041
2Abnormal respiratory motile cilium morphology (HP:0005938)9.28783141
3Abnormal respiratory epithelium morphology (HP:0012253)9.28783141
4Muscle fiber inclusion bodies (HP:0100299)8.28551526
5Nemaline bodies (HP:0003798)8.17294717
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.02059539
7Abnormal ciliary motility (HP:0012262)7.57090120
8Rhinitis (HP:0012384)7.35930701
9Chronic bronchitis (HP:0004469)7.31738213
10Type 1 muscle fiber predominance (HP:0003803)6.91071574
11Infertility (HP:0000789)6.86455403
12Nasal polyposis (HP:0100582)6.38686310
13Muscle fiber splitting (HP:0003555)5.48184754
14Abnormality of the nasal mucosa (HP:0000433)5.29543281
15Exercise-induced muscle cramps (HP:0003710)5.11323520
16Male infertility (HP:0003251)5.07959976
17Muscle hypertrophy of the lower extremities (HP:0008968)4.90331260
18Increased connective tissue (HP:0009025)4.56725740
19Calf muscle hypertrophy (HP:0008981)4.54270721
20Bronchitis (HP:0012387)4.52493984
21EMG: myopathic abnormalities (HP:0003458)4.40901964
22Bronchiectasis (HP:0002110)4.33880419
23Abnormality of the calf musculature (HP:0001430)4.14577622
24Nephronophthisis (HP:0000090)4.09124018
25Difficulty running (HP:0009046)4.07546305
26Distal arthrogryposis (HP:0005684)4.05591789
27Neck muscle weakness (HP:0000467)4.01781672
28Sudden death (HP:0001699)3.90360762
29Abnormality of skeletal muscle fiber size (HP:0012084)3.81571102
30Round ear (HP:0100830)3.74215641
31Distal lower limb muscle weakness (HP:0009053)3.66930267
32Increased variability in muscle fiber diameter (HP:0003557)3.66540579
33Abnormal spermatogenesis (HP:0008669)3.65436248
34Myopathic facies (HP:0002058)3.60467356
35Hyperkalemia (HP:0002153)3.51820902
36Myotonia (HP:0002486)3.49418318
37Recurrent sinusitis (HP:0011108)3.39630837
38Subaortic stenosis (HP:0001682)3.34163912
39Abnormality of the left ventricular outflow tract (HP:0011103)3.34163912
40Centrally nucleated skeletal muscle fibers (HP:0003687)3.25838761
41Aortic aneurysm (HP:0004942)3.24572406
42Recurrent otitis media (HP:0000403)3.24353800
43Frequent falls (HP:0002359)3.20922995
44Rimmed vacuoles (HP:0003805)3.20711090
45Ulnar deviation of the wrist (HP:0003049)3.16034019
46Ventricular tachycardia (HP:0004756)3.15312604
47Abnormality of the renal medulla (HP:0100957)3.07475662
48Muscle stiffness (HP:0003552)2.81372403
49Tubulointerstitial nephritis (HP:0001970)2.80388869
50Heart block (HP:0012722)2.76040984
51Areflexia of lower limbs (HP:0002522)2.71818624
52Abnormal atrioventricular conduction (HP:0005150)2.69571949
53EMG: neuropathic changes (HP:0003445)2.67251158
54Bulbar palsy (HP:0001283)2.66715506
55Recurrent bronchitis (HP:0002837)2.66331165
56Abnormality of midbrain morphology (HP:0002418)2.61070170
57Molar tooth sign on MRI (HP:0002419)2.61070170
58Atrial fibrillation (HP:0005110)2.60904594
59Tubular atrophy (HP:0000092)2.60172870
60Malignant hyperthermia (HP:0002047)2.58112594
61Distal lower limb amyotrophy (HP:0008944)2.55760573
62Lipoatrophy (HP:0100578)2.51975970
63Abnormality of the ischium (HP:0003174)2.50240664
64Spinal rigidity (HP:0003306)2.48799912
65Medial flaring of the eyebrow (HP:0010747)2.46772733
66Mildly elevated creatine phosphokinase (HP:0008180)2.44995042
67Insulin-resistant diabetes mellitus (HP:0000831)2.41209652
68Dilated cardiomyopathy (HP:0001644)2.39626371
69Tubulointerstitial abnormality (HP:0001969)2.39296638
70Primary atrial arrhythmia (HP:0001692)2.36620286
71Dysmetric saccades (HP:0000641)2.31153750
72Absent phalangeal crease (HP:0006109)2.29813770
73Oligomenorrhea (HP:0000876)2.28301980
74Generalized muscle weakness (HP:0003324)2.27813683
75Impulsivity (HP:0100710)2.27459691
76Calcaneovalgus deformity (HP:0001848)2.26506128
77Azoospermia (HP:0000027)2.24891959
78Syncope (HP:0001279)2.23134758
79Atrioventricular block (HP:0001678)2.22886600
80Abnormality of the foot musculature (HP:0001436)2.22715819
81Supraventricular tachycardia (HP:0004755)2.20995409
82Muscular dystrophy (HP:0003560)2.20163623
83Atonic seizures (HP:0010819)2.19542665
84Supraventricular arrhythmia (HP:0005115)2.18819415
85Abnormal gallbladder physiology (HP:0012438)2.18665240
86Cholecystitis (HP:0001082)2.18665240
87Foot dorsiflexor weakness (HP:0009027)2.18457433
88Proximal amyotrophy (HP:0007126)2.16707281
89Gonadotropin excess (HP:0000837)2.15746430
90Hypoalphalipoproteinemia (HP:0003233)2.14901204
91Hip contracture (HP:0003273)2.13760790
92Scapular winging (HP:0003691)2.13568993
93Ventricular fibrillation (HP:0001663)2.11303702
94Dyschromatopsia (HP:0007641)2.10335720
95Ventricular arrhythmia (HP:0004308)2.09990746
96Hypoplastic ischia (HP:0003175)2.09694078
97Complement deficiency (HP:0004431)2.07515809
98Lower limb amyotrophy (HP:0007210)2.02615988
99Gowers sign (HP:0003391)2.02136292
100Fetal akinesia sequence (HP:0001989)2.01980009
101Absent/shortened dynein arms (HP:0200106)13.6344787
102Dynein arm defect of respiratory motile cilia (HP:0012255)13.6344787
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0506941
104Abnormality of potassium homeostasis (HP:0011042)1.96789780
105Action tremor (HP:0002345)1.96248091
106Weak cry (HP:0001612)1.95988309
107Steppage gait (HP:0003376)1.94350311
108Decreased central vision (HP:0007663)1.93269300
109Tubulointerstitial fibrosis (HP:0005576)1.92378542
110Deformed tarsal bones (HP:0008119)1.89000210
111Abnormal finger flexion creases (HP:0006143)1.88569728
112Choroideremia (HP:0001139)1.85485793
113Febrile seizures (HP:0002373)1.84149006
114Slender build (HP:0001533)1.83356049
115Prolonged QT interval (HP:0001657)1.81773882
116Postaxial foot polydactyly (HP:0001830)1.81702081
117Asymmetric septal hypertrophy (HP:0001670)1.81535462
118Stage 5 chronic kidney disease (HP:0003774)1.80809733
119Limited hip movement (HP:0008800)1.80024057
120Cerebral aneurysm (HP:0004944)1.79987840
121Right ventricular cardiomyopathy (HP:0011663)1.77899899
122Waddling gait (HP:0002515)1.77068946
123Hemorrhage of the eye (HP:0011885)1.72655545
124Abnormal EKG (HP:0003115)1.72417213
125Difficulty climbing stairs (HP:0003551)1.71696884
126Polydipsia (HP:0001959)1.70990499
127Abnormal drinking behavior (HP:0030082)1.70990499
128Absence seizures (HP:0002121)1.70319418
129Spastic tetraparesis (HP:0001285)1.69853910
130Congenital hepatic fibrosis (HP:0002612)1.69317204
131Nonprogressive disorder (HP:0003680)1.68588338
132Hypoplasia of the iris (HP:0007676)1.67412312
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66045349
134Abnormal biliary tract physiology (HP:0012439)1.64658406
135Bile duct proliferation (HP:0001408)1.64658406
136Abnormality of complement system (HP:0005339)1.64538363
137Heterotopia (HP:0002282)1.64382811
138Abnormality of renal excretion (HP:0011036)1.63533580
139Postural instability (HP:0002172)1.61615074
140Abnormality of the renal cortex (HP:0011035)1.61486616
141Bell-shaped thorax (HP:0001591)1.57326626
142Short ribs (HP:0000773)1.51939120
143Fibular hypoplasia (HP:0003038)1.51623554
144Abnormality of dentin (HP:0010299)1.50297334
145Aplasia/Hypoplasia of the lens (HP:0008063)1.49823934
146Bundle branch block (HP:0011710)1.49693306
147Oculomotor apraxia (HP:0000657)1.48271998
148Abnormality of the dental root (HP:0006486)1.47064994
149Taurodontia (HP:0000679)1.47064994
150Abnormality of permanent molar morphology (HP:0011071)1.47064994
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.45642991
152Postaxial hand polydactyly (HP:0001162)1.42597155
153Congenital malformation of the right heart (HP:0011723)1.41205138
154Double outlet right ventricle (HP:0001719)1.41205138
155Chronic sinusitis (HP:0011109)1.39698006
156Cystic liver disease (HP:0006706)1.39252189
157Neurofibrillary tangles (HP:0002185)1.38203050
158Abnormality of molar morphology (HP:0011070)1.36900068
159Abnormality of molar (HP:0011077)1.36900068
160Abnormality of the dental pulp (HP:0006479)1.36406249
161Hypoplasia of the capital femoral epiphysis (HP:0003090)1.36169042
162Renal dysplasia (HP:0000110)1.34749079
163Pancreatic fibrosis (HP:0100732)1.33520567
164Microglossia (HP:0000171)1.32520710
165Absent frontal sinuses (HP:0002688)1.32425463
166Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.32031156
167Abnormal urine output (HP:0012590)1.31249721
168Exercise-induced myalgia (HP:0003738)1.29988616
169Facial cleft (HP:0002006)1.29274073
170Congenital primary aphakia (HP:0007707)1.26871317
171Constricted visual fields (HP:0001133)1.26811849
172Abnormality of the lower motor neuron (HP:0002366)1.26614170
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.26541829
174Gait imbalance (HP:0002141)1.26138501
175Aplasia/Hypoplasia of the tongue (HP:0010295)1.25479611
176Deformed sella turcica (HP:0002681)1.24814136
177Easy fatigability (HP:0003388)1.23150516
178Myoglobinuria (HP:0002913)1.21785511
179Abnormality of saccadic eye movements (HP:0000570)1.19788839
180Sensory axonal neuropathy (HP:0003390)1.19245914
181Hyporeflexia of lower limbs (HP:0002600)1.17863760
182Fatigable weakness (HP:0003473)1.17698889
183Abnormality of the neuromuscular junction (HP:0003398)1.17698889
184Rhabdomyolysis (HP:0003201)1.16515379
185Cerebellar dysplasia (HP:0007033)1.14916060
186Optic nerve hypoplasia (HP:0000609)1.14338966
187Short thorax (HP:0010306)1.14183775
188Vascular calcification (HP:0004934)1.14180218
189Cerebral inclusion bodies (HP:0100314)1.13494931
190Nephropathy (HP:0000112)1.13398488
191Truncal obesity (HP:0001956)1.13230078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.82176062
2PDK48.82176062
3OBSCN7.59947080
4PDK25.73389876
5TESK15.60525387
6PRKD34.66972524
7ICK3.98690401
8PHKG23.64966605
9PHKG13.64966605
10TIE12.48783216
11PTK2B2.20148796
12DDR22.02653285
13WNK41.90198057
14STK391.88412862
15MAPK121.87164436
16DMPK1.80274893
17TRPM71.71917678
18MAP3K71.68532226
19PNCK1.65557138
20EPHA31.59670268
21STK381.57314978
22PRKAA21.55649378
23MAP3K131.36781419
24DYRK1B1.36458056
25INSRR1.35713415
26LATS11.29859778
27NEK21.29367239
28AKT31.28771532
29MARK11.27869255
30TGFBR21.24167973
31PDK11.23986568
32LATS21.18291336
33SGK21.13749861
34CAMK11.11329558
35PIK3CA1.02293906
36NLK1.00629017
37SGK2230.97430187
38SGK4940.97430187
39CAMK2G0.96441233
40MAPKAPK30.92155715
41MOS0.90272211
42CAMK40.88413138
43MAPK70.85745600
44MAPK150.85293976
45FER0.85229614
46SGK30.82064860
47IRAK10.80261966
48MAPK40.79050755
49TYRO30.77167866
50MAP3K90.76265638
51KSR20.75276905
52MAP2K40.74442911
53DYRK30.74421292
54PDGFRA0.73600824
55PDPK10.73588656
56EPHB10.72948311
57WNK10.72302100
58MAP3K60.72075560
59NTRK30.71080906
60ROCK10.69335060
61LMTK20.68274958
62BLK0.66879985
63NEK90.64985394
64CAMK2D0.63204497
65STK30.60467800
66SGK10.57136029
67MAP2K60.56625557
68CAMK1G0.56315069
69CCNB10.55777447
70PASK0.55693419
71RIPK40.54452472
72TTK0.53475906
73EEF2K0.53382302
74STK38L0.51815386
75CAMK2B0.51180782
76MAP2K30.51094782
77MAP3K10.50319420
78PRKD10.50137962
79FGFR30.49354697
80CDC42BPA0.48923002
81FES0.48839637
82CHEK20.48777071
83PAK20.48632620
84GRK50.48519399
85MAP2K10.48292832
86MAPK100.45776294
87JAK10.45742106
88RPS6KA20.45490743
89ARAF0.45252593
90IRAK20.43466912
91AKT20.43220591
92PAK10.42151240
93PINK10.40811048
94MUSK0.40725795
95MAPK110.36012862
96RET0.33988633
97BRD40.33897388
98RPS6KL10.31247710
99RPS6KC10.31247710
100KIT0.31090775
101CHEK10.30587486
102MET0.30522037
103DAPK20.29944812
104CDK50.29802970
105JAK20.29266199
106TESK20.29042844
107PRKCG0.28572190
108MAP3K100.28179062
109NTRK20.27365581
110MYLK0.25921655
111MTOR0.25147302
112MAPKAPK50.22278066
113ATM0.22088394
114MARK20.21916826
115TTN0.19703377
116PRKG20.19484366
117NEK60.17858965
118PRKAA10.17733447
119PRKCZ0.17149788
120CAMKK10.15855381
121PLK40.15631565
122BRSK20.13666028
123ATR0.12388599
124PRKCQ0.12375637
125PAK40.11077448
126RPS6KB10.10840076
127CDK150.10836118
128WEE10.08397249
129CDK180.08149168
130BRAF0.08022175
131PRKG10.06635409
132CAMK2A0.06452553
133PIK3CG0.06417781
134PDGFRB0.06361256
135CDK11A0.06138635
136STK110.05991609
137PKN10.05908707
138PLK10.05416055
139GSK3B0.04303014
140RPS6KA10.04260737
141CDK140.04031565
142CSNK2A10.03792296
143STK100.03311801
144PRKACG0.03173096
145GSK3A0.02884911
146CDK60.02777251
147CDC70.02757315
148TRIB30.02735802
149FRK0.02692111
150PRKCB0.02367844
151PRKCD0.01817529
152PRKCA0.01635575
153RIPK10.01311745
154MAPK80.01090567
155MARK30.01082030
156CSNK2A20.00943882
157CSNK1D0.00740902
158EGFR0.00262923
159PAK6-0.0250500
160PRKACA-0.0205598
161CSF1R-0.0167227
162CDK2-0.0163402
163PRKACB-0.0156747
164ZAP70-0.0126332
165RPS6KA3-0.0103372
166CDK1-0.0074371
167WNK3-0.0046814
168BRSK1-0.0036599

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.51753540
2Fatty acid biosynthesis_Homo sapiens_hsa000614.44302257
3Pyruvate metabolism_Homo sapiens_hsa006203.51788763
4Vitamin B6 metabolism_Homo sapiens_hsa007503.50295750
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.01086578
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98485221
7Dilated cardiomyopathy_Homo sapiens_hsa054142.92398029
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.90146429
9Linoleic acid metabolism_Homo sapiens_hsa005912.89864993
10Propanoate metabolism_Homo sapiens_hsa006402.74717068
11Glucagon signaling pathway_Homo sapiens_hsa049222.61145001
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.28957735
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.27998775
14Circadian rhythm_Homo sapiens_hsa047102.15433314
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03911702
16Glycerolipid metabolism_Homo sapiens_hsa005611.98715697
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95901203
18Basal transcription factors_Homo sapiens_hsa030221.95541843
19PPAR signaling pathway_Homo sapiens_hsa033201.92348003
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.86369601
21Selenocompound metabolism_Homo sapiens_hsa004501.85050808
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.77135510
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75862459
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71857345
25Oocyte meiosis_Homo sapiens_hsa041141.71709128
26Phenylalanine metabolism_Homo sapiens_hsa003601.71339664
27Pentose phosphate pathway_Homo sapiens_hsa000301.70508266
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66408197
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.65399208
30ECM-receptor interaction_Homo sapiens_hsa045121.62580327
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.62438402
32Dorso-ventral axis formation_Homo sapiens_hsa043201.58687437
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51887941
34Mineral absorption_Homo sapiens_hsa049781.49733335
35Fat digestion and absorption_Homo sapiens_hsa049751.46748991
36Fructose and mannose metabolism_Homo sapiens_hsa000511.40387615
37Amphetamine addiction_Homo sapiens_hsa050311.39833917
38Ether lipid metabolism_Homo sapiens_hsa005651.35917743
39Fatty acid metabolism_Homo sapiens_hsa012121.35007308
40Carbon metabolism_Homo sapiens_hsa012001.34242358
41Arginine biosynthesis_Homo sapiens_hsa002201.33764328
42Fatty acid degradation_Homo sapiens_hsa000711.32282003
43Cardiac muscle contraction_Homo sapiens_hsa042601.30759420
44Renin secretion_Homo sapiens_hsa049241.29822804
45Focal adhesion_Homo sapiens_hsa045101.27728894
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24376405
47Insulin signaling pathway_Homo sapiens_hsa049101.20553079
48Olfactory transduction_Homo sapiens_hsa047401.13725782
49Long-term depression_Homo sapiens_hsa047301.11648695
50GABAergic synapse_Homo sapiens_hsa047271.10095016
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06300637
52Morphine addiction_Homo sapiens_hsa050321.06276222
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04892042
54Gap junction_Homo sapiens_hsa045401.02196003
55Nitrogen metabolism_Homo sapiens_hsa009101.01270156
56Antigen processing and presentation_Homo sapiens_hsa046121.00485632
57Fanconi anemia pathway_Homo sapiens_hsa034600.98273163
58Histidine metabolism_Homo sapiens_hsa003400.97294058
59Purine metabolism_Homo sapiens_hsa002300.96447341
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.96339570
61Glutamatergic synapse_Homo sapiens_hsa047240.95258369
62Arginine and proline metabolism_Homo sapiens_hsa003300.94863004
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94696197
64Cholinergic synapse_Homo sapiens_hsa047250.93324390
65Ovarian steroidogenesis_Homo sapiens_hsa049130.91058452
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90128507
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89145931
68GnRH signaling pathway_Homo sapiens_hsa049120.88194552
69Bile secretion_Homo sapiens_hsa049760.87725928
70Insulin secretion_Homo sapiens_hsa049110.87631682
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86589735
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86144220
73Glutathione metabolism_Homo sapiens_hsa004800.84932071
74Tyrosine metabolism_Homo sapiens_hsa003500.84172013
75mRNA surveillance pathway_Homo sapiens_hsa030150.84050229
76Thyroid hormone synthesis_Homo sapiens_hsa049180.83290210
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83286793
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.82218666
79Estrogen signaling pathway_Homo sapiens_hsa049150.81991402
80Renin-angiotensin system_Homo sapiens_hsa046140.81629153
81Huntingtons disease_Homo sapiens_hsa050160.81016826
82Biosynthesis of amino acids_Homo sapiens_hsa012300.80504189
83Hedgehog signaling pathway_Homo sapiens_hsa043400.80456473
84Protein digestion and absorption_Homo sapiens_hsa049740.78846517
85Chemical carcinogenesis_Homo sapiens_hsa052040.74725900
86Type II diabetes mellitus_Homo sapiens_hsa049300.74524065
87Arachidonic acid metabolism_Homo sapiens_hsa005900.73351148
88Collecting duct acid secretion_Homo sapiens_hsa049660.72524668
89Platelet activation_Homo sapiens_hsa046110.72460919
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71584883
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.70200932
92Complement and coagulation cascades_Homo sapiens_hsa046100.69328215
93Nicotine addiction_Homo sapiens_hsa050330.68351018
94Long-term potentiation_Homo sapiens_hsa047200.67199378
95Serotonergic synapse_Homo sapiens_hsa047260.66154377
96Salivary secretion_Homo sapiens_hsa049700.64832563
97Adherens junction_Homo sapiens_hsa045200.64191630
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.64053731
99Pancreatic secretion_Homo sapiens_hsa049720.63336522
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.62592036
101Gastric acid secretion_Homo sapiens_hsa049710.61780771
102Tryptophan metabolism_Homo sapiens_hsa003800.61013394
103Calcium signaling pathway_Homo sapiens_hsa040200.59714523
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59565705
105Inositol phosphate metabolism_Homo sapiens_hsa005620.58133459
106RNA transport_Homo sapiens_hsa030130.56334378
107FoxO signaling pathway_Homo sapiens_hsa040680.56232363
108beta-Alanine metabolism_Homo sapiens_hsa004100.56000485
109MAPK signaling pathway_Homo sapiens_hsa040100.55690565
110Systemic lupus erythematosus_Homo sapiens_hsa053220.55158232
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54892946
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54360204
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54311477
114Butanoate metabolism_Homo sapiens_hsa006500.53180667
115Viral myocarditis_Homo sapiens_hsa054160.53162756
116Legionellosis_Homo sapiens_hsa051340.52223033
117Amoebiasis_Homo sapiens_hsa051460.50483240
118AMPK signaling pathway_Homo sapiens_hsa041520.50193015
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49032705
120Malaria_Homo sapiens_hsa051440.48648629
121Dopaminergic synapse_Homo sapiens_hsa047280.48480534
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47900014
123ABC transporters_Homo sapiens_hsa020100.47764885
124Endocytosis_Homo sapiens_hsa041440.47636211
125cAMP signaling pathway_Homo sapiens_hsa040240.47624286
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46868434
127Glioma_Homo sapiens_hsa052140.46781662
128Prion diseases_Homo sapiens_hsa050200.45378175
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44354573
130mTOR signaling pathway_Homo sapiens_hsa041500.44206632
131Choline metabolism in cancer_Homo sapiens_hsa052310.43294804
132Sulfur metabolism_Homo sapiens_hsa009200.43027868
133Taste transduction_Homo sapiens_hsa047420.41391077
134Melanogenesis_Homo sapiens_hsa049160.40111229
135Circadian entrainment_Homo sapiens_hsa047130.36437269
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34165814
137VEGF signaling pathway_Homo sapiens_hsa043700.33369589
138Metabolic pathways_Homo sapiens_hsa011000.32702241
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30436932
140Synaptic vesicle cycle_Homo sapiens_hsa047210.28254214
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26306706
142Alcoholism_Homo sapiens_hsa050340.20440031
143Cocaine addiction_Homo sapiens_hsa050300.18132523
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17017487
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15781923
146Wnt signaling pathway_Homo sapiens_hsa043100.12889315
147HIF-1 signaling pathway_Homo sapiens_hsa040660.12383799
148Insulin resistance_Homo sapiens_hsa049310.11603478
149Salmonella infection_Homo sapiens_hsa051320.10490923
150Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09633105
151Oxytocin signaling pathway_Homo sapiens_hsa049210.06888571
152Basal cell carcinoma_Homo sapiens_hsa052170.05451828
153Tight junction_Homo sapiens_hsa045300.05092637

Most similar genes based on co-expression Upload to Enrichr

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