FHOD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* sarcomere organization (GO:0045214)7.82181657
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.59425237
3* cardiac myofibril assembly (GO:0055003)7.43131069
4negative regulation of potassium ion transmembrane transport (GO:1901380)7.06978486
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.81922887
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.46651084
7* myofibril assembly (GO:0030239)6.44609908
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.28001069
9cardiac muscle contraction (GO:0060048)6.26215720
10cardiac muscle cell development (GO:0055013)6.17069848
11regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.08820330
12cardiac cell development (GO:0055006)5.79042392
13ventricular cardiac muscle cell action potential (GO:0086005)5.76326109
14tricarboxylic acid cycle (GO:0006099)5.69488119
15muscle filament sliding (GO:0030049)5.63563664
16actin-myosin filament sliding (GO:0033275)5.63563664
17regulation of actin filament-based movement (GO:1903115)5.60270618
18plasma membrane repair (GO:0001778)5.50222297
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.47841387
20regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.47078339
21regulation of relaxation of muscle (GO:1901077)5.30779961
22adult heart development (GO:0007512)5.15051373
23cardiac muscle hypertrophy (GO:0003300)5.12244042
24cell communication involved in cardiac conduction (GO:0086065)5.05352907
25regulation of membrane repolarization (GO:0060306)5.03555336
26bundle of His cell to Purkinje myocyte communication (GO:0086069)5.00008764
27cardiac muscle tissue morphogenesis (GO:0055008)4.99862901
28regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.99012266
29* actomyosin structure organization (GO:0031032)4.96763570
30ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.91873168
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.86865836
32striated muscle hypertrophy (GO:0014897)4.85474954
33actin-mediated cell contraction (GO:0070252)4.83546794
34regulation of sarcomere organization (GO:0060297)4.78572125
35cell communication by electrical coupling (GO:0010644)4.78101108
36striated muscle contraction (GO:0006941)4.70394566
37carnitine shuttle (GO:0006853)4.66221853
38heart trabecula formation (GO:0060347)4.65546839
39regulation of cell communication by electrical coupling (GO:0010649)4.63521677
40sarcoplasmic reticulum calcium ion transport (GO:0070296)4.62220566
41regulation of skeletal muscle contraction (GO:0014819)4.58046849
42regulation of striated muscle contraction (GO:0006942)4.56287304
43regulation of the force of heart contraction (GO:0002026)4.54556240
44cardiac chamber formation (GO:0003207)4.49162685
45regulation of acyl-CoA biosynthetic process (GO:0050812)4.48537751
46muscle tissue morphogenesis (GO:0060415)4.46197344
47regulation of cardioblast differentiation (GO:0051890)4.40401185
48relaxation of cardiac muscle (GO:0055119)4.20634645
49muscle hypertrophy (GO:0014896)4.18594835
50heart process (GO:0003015)4.14297618
51heart contraction (GO:0060047)4.14297618
52regulation of cofactor metabolic process (GO:0051193)4.11353781
53regulation of coenzyme metabolic process (GO:0051196)4.11353781
54regulation of cardiac muscle cell contraction (GO:0086004)4.08790760
55cardiac ventricle formation (GO:0003211)4.08694605
56cardiac muscle cell action potential (GO:0086001)4.05703991
57cardiac muscle cell action potential involved in contraction (GO:0086002)4.05337703
58regulation of cardiac muscle contraction (GO:0055117)4.05147839
59negative regulation of potassium ion transport (GO:0043267)3.96703701
60regulation of heart rate (GO:0002027)3.93900095
61response to inactivity (GO:0014854)3.93057517
62fatty acid transmembrane transport (GO:1902001)3.91041176
63negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.86244723
64positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.85421169
65cardiac conduction (GO:0061337)3.78200720
66detection of calcium ion (GO:0005513)3.74408085
67ventricular cardiac muscle cell development (GO:0055015)3.73927092
68actin filament-based movement (GO:0030048)3.71307306
69cardiac muscle hypertrophy in response to stress (GO:0014898)3.68842054
70muscle hypertrophy in response to stress (GO:0003299)3.68842054
71cardiac muscle adaptation (GO:0014887)3.68842054
72atrial septum morphogenesis (GO:0060413)3.66714474
73regulation of heart rate by cardiac conduction (GO:0086091)3.66236761
74regulation of heart contraction (GO:0008016)3.64268944
75potassium ion export (GO:0071435)3.55792765
76positive regulation of potassium ion transmembrane transport (GO:1901381)3.51504518
77positive regulation of cation channel activity (GO:2001259)3.48050728
78regulation of calcium ion transmembrane transport (GO:1903169)3.46162088
79regulation of calcium ion transmembrane transporter activity (GO:1901019)3.46162088
80positive regulation of heart contraction (GO:0045823)3.45165885
81membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.44830613
82striated muscle cell development (GO:0055002)3.43012290
83regulation of ATPase activity (GO:0043462)3.39187869
84regulation of ATP catabolic process (GO:1903289)3.39187869
85carnitine transmembrane transport (GO:1902603)3.38224169
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38197591
87NADH metabolic process (GO:0006734)3.36350647
88regulation of sulfur metabolic process (GO:0042762)3.36230095
89negative regulation of striated muscle cell apoptotic process (GO:0010664)3.36119908
90neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.35546185
91response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.34600479
92negative regulation of protein localization to cell surface (GO:2000009)3.31117462
93positive regulation of heart rate (GO:0010460)3.26102238
94negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24706948
95oxygen transport (GO:0015671)3.24313352
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13844425
97muscle cell cellular homeostasis (GO:0046716)3.12898169
98muscle system process (GO:0003012)3.12671950
99amino-acid betaine transport (GO:0015838)3.12515937
100carnitine transport (GO:0015879)3.12515937
1012-oxoglutarate metabolic process (GO:0006103)3.09248958
102muscle contraction (GO:0006936)3.09169354
103positive regulation of cardiac muscle cell differentiation (GO:2000727)3.08297029
104regulation of potassium ion transmembrane transporter activity (GO:1901016)3.08031747
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07900781
106membrane repolarization during action potential (GO:0086011)3.06942172
107striated muscle adaptation (GO:0014888)3.04527165
108response to muscle activity (GO:0014850)3.03974352
109regulation of muscle contraction (GO:0006937)3.02821530
110regulation of potassium ion transmembrane transport (GO:1901379)2.99606156
111cardiac muscle tissue development (GO:0048738)2.97241983
112muscle cell development (GO:0055001)2.92968794
113atrioventricular valve morphogenesis (GO:0003181)2.92954711
114regulation of cardiac muscle cell differentiation (GO:2000725)2.92256221
115positive regulation of cardiac muscle tissue growth (GO:0055023)2.90420960
116adrenergic receptor signaling pathway (GO:0071875)2.90416668
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89206019
118regulation of muscle system process (GO:0090257)2.87021172
119cellular response to epinephrine stimulus (GO:0071872)2.83582582
120response to epinephrine (GO:0071871)2.82929749
121positive regulation of cardiac muscle tissue development (GO:0055025)2.81555380
122muscle fiber development (GO:0048747)2.80748467
123relaxation of muscle (GO:0090075)2.76339174
124response to caffeine (GO:0031000)2.75726115
125positive regulation of cardiac muscle cell proliferation (GO:0060045)2.74867129
126skeletal muscle contraction (GO:0003009)2.74121194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EP300_21415370_ChIP-Seq_HL-1_Mouse4.25765806
2EZH2_22144423_ChIP-Seq_EOC_Human3.88673691
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.54704892
4TBX20_22328084_ChIP-Seq_HEART_Mouse3.09649619
5TBX20_22080862_ChIP-Seq_HEART_Mouse3.09649619
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07163805
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93926014
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.85018165
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.79408831
10ZNF263_19887448_ChIP-Seq_K562_Human2.53604666
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.51810990
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13660999
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08073136
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03299906
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.98091141
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91218350
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90638273
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.75599721
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69964725
20GATA4_21415370_ChIP-Seq_HL-1_Mouse1.66462693
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.66013975
22DROSHA_22980978_ChIP-Seq_HELA_Human1.64666536
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59141523
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56496492
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53856956
26NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47585937
27ISL1_27105846_Chip-Seq_CPCs_Mouse1.45634027
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41670965
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41670965
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41429879
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40840860
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.37084220
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36331298
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36151546
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35966763
36VDR_22108803_ChIP-Seq_LS180_Human1.35789357
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.34689906
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.33985287
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33329566
40* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30586115
41* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28578280
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.28532173
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27480820
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26665421
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26207256
46* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25979826
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25734100
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23596777
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.21686717
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20928208
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19875939
52* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19222017
53SMAD4_21799915_ChIP-Seq_A2780_Human1.19205611
54* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18286450
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18131667
56* SMAD3_21741376_ChIP-Seq_HESCs_Human1.17569805
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.17471083
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17286502
59* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16081021
60KDM2B_26808549_Chip-Seq_K562_Human1.15729457
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14565001
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14420282
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.14126991
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13128703
65ZNF274_21170338_ChIP-Seq_K562_Hela1.12538757
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11948424
67* SMAD4_21741376_ChIP-Seq_HESCs_Human1.11279184
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11185782
69GBX2_23144817_ChIP-Seq_PC3_Human1.10488795
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10249990
71* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10023056
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09538840
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.09442176
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08652415
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.07732036
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07624176
77TP53_18474530_ChIP-ChIP_U2OS_Human1.07422376
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.06731942
79* AR_19668381_ChIP-Seq_PC3_Human1.05789902
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05629629
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.04949604
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04631428
83* CTCF_27219007_Chip-Seq_Bcells_Human1.03426687
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03001541
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02831568
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02500962
87* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02490742
88* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02480000
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02356030
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02187816
91AHR_22903824_ChIP-Seq_MCF-7_Human1.02000629
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01361992
93* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00554481
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00453921
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00338591
96* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99923820
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99467274
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98210204
99RNF2_27304074_Chip-Seq_NSC_Mouse0.97846800
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97282430
101SOX9_26525672_Chip-Seq_HEART_Mouse0.96224147
102TP63_22573176_ChIP-Seq_HFKS_Human0.95760831
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93514363
104REST_18959480_ChIP-ChIP_MESCs_Mouse0.93077555
105KDM2B_26808549_Chip-Seq_DND41_Human0.91745657
106FOXA2_19822575_ChIP-Seq_HepG2_Human0.90158826
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89992725
108TBL1_22424771_ChIP-Seq_293T_Human0.89871392
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89320911
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89218165
111* TCF4_23295773_ChIP-Seq_U87_Human0.89009840
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89008969
113* RUNX1_27514584_Chip-Seq_MCF-7_Human0.88942785
114TP53_16413492_ChIP-PET_HCT116_Human0.87879644
115AR_21572438_ChIP-Seq_LNCaP_Human0.87645157
116* STAT3_23295773_ChIP-Seq_U87_Human0.87135822
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.87091452
118SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87027678
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85766769
120* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85273845
121* BCAT_22108803_ChIP-Seq_LS180_Human0.85073408
122JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83855874
123PIAS1_25552417_ChIP-Seq_VCAP_Human0.83793957
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83465717
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83401270
126ATF3_27146783_Chip-Seq_COLON_Human0.82328622
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.82130189
128CJUN_26792858_Chip-Seq_BT549_Human0.82046719
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81416204
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81217098
131TP53_23651856_ChIP-Seq_MEFs_Mouse0.80976110
132SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79331229
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78272367
134* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.77254305
135TBX3_20139965_ChIP-Seq_MESCs_Mouse0.77112732
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.77089422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.80961469
2MP0003646_muscle_fatigue5.80763055
3MP0004084_abnormal_cardiac_muscle5.64375403
4MP0000751_myopathy4.91808397
5MP0004215_abnormal_myocardial_fiber4.88444467
6MP0004036_abnormal_muscle_relaxation4.12582752
7MP0005330_cardiomyopathy3.67258678
8MP0000749_muscle_degeneration3.34801446
9MP0002972_abnormal_cardiac_muscle3.10353137
10MP0003137_abnormal_impulse_conducting2.95455893
11MP0004087_abnormal_muscle_fiber2.88917143
12MP0008775_abnormal_heart_ventricle2.85264260
13MP0005620_abnormal_muscle_contractility2.69015219
14MP0004484_altered_response_of2.51070831
15MP0000750_abnormal_muscle_regeneration2.47881429
16MP0005385_cardiovascular_system_phenoty2.45273356
17MP0001544_abnormal_cardiovascular_syste2.45273356
18MP0010630_abnormal_cardiac_muscle2.44909787
19MP0006138_congestive_heart_failure2.38336147
20MP0002106_abnormal_muscle_physiology2.34760030
21MP0004130_abnormal_muscle_cell2.33201974
22MP0004085_abnormal_heartbeat2.28915207
23MP0004145_abnormal_muscle_electrophysio2.22670615
24MP0002269_muscular_atrophy2.14427530
25MP0004510_myositis1.98396448
26MP0003828_pulmonary_edema1.95738141
27MP0004233_abnormal_muscle_weight1.91579227
28MP0005369_muscle_phenotype1.87854193
29MP0003221_abnormal_cardiomyocyte_apopto1.87182965
30MP0000747_muscle_weakness1.73595014
31MP0002127_abnormal_cardiovascular_syste1.73389260
32MP0000759_abnormal_skeletal_muscle1.72842423
33MP0003950_abnormal_plasma_membrane1.44790753
34MP0002234_abnormal_pharynx_morphology1.35451484
35MP0006036_abnormal_mitochondrial_physio1.31644774
36MP0005666_abnormal_adipose_tissue1.27685874
37MP0002332_abnormal_exercise_endurance1.26378119
38MP0003567_abnormal_fetal_cardiomyocyte1.21067718
39MP0000266_abnormal_heart_morphology1.13087107
40MP0004185_abnormal_adipocyte_glucose1.12811372
41MP0010030_abnormal_orbit_morphology1.10538065
42MP0010368_abnormal_lymphatic_system1.06713430
43MP0005451_abnormal_body_composition1.05987343
44MP0002909_abnormal_adrenal_gland1.03910675
45MP0004043_abnormal_pH_regulation0.99206020
46MP0008438_abnormal_cutaneous_collagen0.98363936
47MP0005623_abnormal_meninges_morphology0.96782571
48MP0005503_abnormal_tendon_morphology0.94958344
49MP0001661_extended_life_span0.91879953
50MP0005375_adipose_tissue_phenotype0.87382553
51MP0005165_increased_susceptibility_to0.86754177
52MP0000762_abnormal_tongue_morphology0.85408517
53MP0005187_abnormal_penis_morphology0.85192380
54MP0005670_abnormal_white_adipose0.83630532
55MP0000778_abnormal_nervous_system0.82867604
56MP0009780_abnormal_chondrocyte_physiolo0.82105839
57MP0000230_abnormal_systemic_arterial0.82102889
58MP0001984_abnormal_olfaction0.82006574
59MP0003283_abnormal_digestive_organ0.81888356
60MP0000537_abnormal_urethra_morphology0.79661162
61MP0005275_abnormal_skin_tensile0.78227674
62MP0005423_abnormal_somatic_nervous0.77612275
63MP0006035_abnormal_mitochondrial_morpho0.76440573
64MP0000534_abnormal_ureter_morphology0.74743508
65MP0000462_abnormal_digestive_system0.73221338
66MP0000343_altered_response_to0.72286454
67MP0006072_abnormal_retinal_apoptosis0.71515495
68MP0009250_abnormal_appendicular_skeleto0.71107963
69MP0003385_abnormal_body_wall0.69160730
70MP0000049_abnormal_middle_ear0.68952027
71MP0008789_abnormal_olfactory_epithelium0.68914530
72MP0001958_emphysema0.67763218
73MP0004859_abnormal_synaptic_plasticity0.67740070
74MP0004924_abnormal_behavior0.67529964
75MP0005386_behavior/neurological_phenoty0.67529964
76MP0003705_abnormal_hypodermis_morpholog0.66125800
77MP0008961_abnormal_basal_metabolism0.65650748
78MP0002102_abnormal_ear_morphology0.65589999
79MP0000003_abnormal_adipose_tissue0.65498575
80MP0005409_darkened_coat_color0.65456937
81MP0002108_abnormal_muscle_morphology0.65296458
82MP0002128_abnormal_blood_circulation0.64494622
83MP0003279_aneurysm0.64074483
84MP0005266_abnormal_metabolism0.63958389
85MP0002653_abnormal_ependyma_morphology0.63028525
86MP0002822_catalepsy0.62480037
87MP0006276_abnormal_autonomic_nervous0.62052987
88MP0005499_abnormal_olfactory_system0.61965204
89MP0005394_taste/olfaction_phenotype0.61965204
90MP0002896_abnormal_bone_mineralization0.61730599
91MP0000013_abnormal_adipose_tissue0.61095761
92MP0003942_abnormal_urinary_system0.57424127
93MP0002249_abnormal_larynx_morphology0.56877195
94MP0002877_abnormal_melanocyte_morpholog0.56729856
95MP0000428_abnormal_craniofacial_morphol0.56235981
96MP0003566_abnormal_cell_adhesion0.55679167
97MP0003937_abnormal_limbs/digits/tail_de0.55405091
98MP0000579_abnormal_nail_morphology0.55008355
99MP0003755_abnormal_palate_morphology0.54735398
100MP0005248_abnormal_Harderian_gland0.54493660
101MP0003941_abnormal_skin_development0.54341459
102MP0000566_synostosis0.53742254
103MP0002233_abnormal_nose_morphology0.53272501
104MP0002078_abnormal_glucose_homeostasis0.52962348
105MP0004270_analgesia0.52946037
106MP0003880_abnormal_central_pattern0.51757329
107MP0006292_abnormal_olfactory_placode0.50893967
108MP0002925_abnormal_cardiovascular_devel0.49832454
109MP0003984_embryonic_growth_retardation0.49547387
110MP0000767_abnormal_smooth_muscle0.48965487
111MP0002088_abnormal_embryonic_growth/wei0.48108445
112MP0000733_abnormal_muscle_development0.45764268
113MP0004272_abnormal_basement_membrane0.45505837
114MP0001784_abnormal_fluid_regulation0.42192988
115MP0003635_abnormal_synaptic_transmissio0.41802614
116MP0002971_abnormal_brown_adipose0.37379918
117MP0005551_abnormal_eye_electrophysiolog0.34961475
118MP0001529_abnormal_vocalization0.34495526
119MP0005535_abnormal_body_temperature0.33841633
120MP0001672_abnormal_embryogenesis/_devel0.33518523
121MP0005380_embryogenesis_phenotype0.33518523
122MP0001299_abnormal_eye_distance/0.31863853
123MP0009384_cardiac_valve_regurgitation0.31691049
124MP0001614_abnormal_blood_vessel0.30825637
125MP0001765_abnormal_ion_homeostasis0.27411863
126MP0003935_abnormal_craniofacial_develop0.27365317
127MP0003045_fibrosis0.27066461
128MP0008569_lethality_at_weaning0.26747416
129MP0004858_abnormal_nervous_system0.26530671
130MP0001879_abnormal_lymphatic_vessel0.26489206
131MP0003948_abnormal_gas_homeostasis0.25542476
132MP0002063_abnormal_learning/memory/cond0.24022728
133MP0010386_abnormal_urinary_bladder0.23326572
134MP0002734_abnormal_mechanical_nocicepti0.22151395
135MP0002272_abnormal_nervous_system0.20552448
136MP0001727_abnormal_embryo_implantation0.20500470

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.68888281
2Ventricular tachycardia (HP:0004756)6.91168291
3Atrial fibrillation (HP:0005110)6.37107162
4Primary atrial arrhythmia (HP:0001692)5.98564701
5Calf muscle hypertrophy (HP:0008981)5.95705551
6Supraventricular tachycardia (HP:0004755)5.74704934
7Supraventricular arrhythmia (HP:0005115)5.63567301
8Syncope (HP:0001279)5.47621837
9Muscle hypertrophy of the lower extremities (HP:0008968)5.39692295
10Muscle fiber splitting (HP:0003555)5.33101732
11Exercise-induced muscle cramps (HP:0003710)5.24970800
12Exercise-induced myalgia (HP:0003738)5.24115893
13Lipoatrophy (HP:0100578)5.23293703
14Bundle branch block (HP:0011710)5.15854219
15Abnormality of the calf musculature (HP:0001430)5.15724838
16Subaortic stenosis (HP:0001682)5.14835938
17Abnormality of the left ventricular outflow tract (HP:0011103)5.14835938
18Right ventricular cardiomyopathy (HP:0011663)5.08970438
19Prolonged QT interval (HP:0001657)4.74422116
20Ventricular fibrillation (HP:0001663)4.55900331
21Hyporeflexia of lower limbs (HP:0002600)4.54822823
22Ventricular arrhythmia (HP:0004308)4.39563819
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.30795037
24Dilated cardiomyopathy (HP:0001644)4.25265217
25Muscle fiber inclusion bodies (HP:0100299)4.25174768
26Myoglobinuria (HP:0002913)4.23786018
27Palpitations (HP:0001962)4.18110920
28Heart block (HP:0012722)4.09541254
29Nemaline bodies (HP:0003798)4.06095785
30Atrioventricular block (HP:0001678)4.00032960
31Asymmetric septal hypertrophy (HP:0001670)3.91409689
32Abnormal atrioventricular conduction (HP:0005150)3.83368930
33EMG: myopathic abnormalities (HP:0003458)3.80980160
34Abnormal EKG (HP:0003115)3.44608037
35Left ventricular hypertrophy (HP:0001712)3.39543187
36Increased connective tissue (HP:0009025)3.30099244
37Myotonia (HP:0002486)3.28721882
38Centrally nucleated skeletal muscle fibers (HP:0003687)3.27031368
39Difficulty running (HP:0009046)3.21532333
40Rhabdomyolysis (HP:0003201)2.99409355
41Ketoacidosis (HP:0001993)2.95124607
42Difficulty climbing stairs (HP:0003551)2.67936295
43Central scotoma (HP:0000603)2.67362802
44Palmoplantar keratoderma (HP:0000982)2.62819058
45Hip contracture (HP:0003273)2.50811033
46Dysmetric saccades (HP:0000641)2.48855425
47Hypoglycemic coma (HP:0001325)2.31333520
48Abnormal mitochondria in muscle tissue (HP:0008316)2.31188154
49Limited hip movement (HP:0008800)2.25811767
50Pheochromocytoma (HP:0002666)2.22604087
51Acute necrotizing encephalopathy (HP:0006965)2.22350834
52Hypoplastic left heart (HP:0004383)2.20314966
53Testicular atrophy (HP:0000029)2.20014193
54Increased variability in muscle fiber diameter (HP:0003557)2.18278693
55Hepatic necrosis (HP:0002605)2.18149468
56Aortic aneurysm (HP:0004942)2.17146320
57Ragged-red muscle fibers (HP:0003200)2.15473378
58EMG: neuropathic changes (HP:0003445)2.14238489
59Conjunctival hamartoma (HP:0100780)2.12142009
60Sudden cardiac death (HP:0001645)2.11843541
61Distal arthrogryposis (HP:0005684)2.11064975
62Neck muscle weakness (HP:0000467)2.09901347
63Limb-girdle muscle atrophy (HP:0003797)2.09749796
64Hamartoma of the eye (HP:0010568)2.08813338
65Areflexia of lower limbs (HP:0002522)2.04114651
66Hypoplastic ischia (HP:0003175)2.03780643
67Myopathic facies (HP:0002058)2.03649525
68Spinal rigidity (HP:0003306)2.03177824
69Protrusio acetabuli (HP:0003179)2.01766324
70Abnormality of the foot musculature (HP:0001436)2.01138563
71Hyperinsulinemic hypoglycemia (HP:0000825)2.00684758
72Round ear (HP:0100830)2.00355800
73Hyperglycemia (HP:0003074)1.99838447
74Hypoplastic heart (HP:0001961)1.98041666
75Abnormality of the shoulder girdle musculature (HP:0001435)1.97100818
76Large for gestational age (HP:0001520)1.96459625
77Myokymia (HP:0002411)1.95706037
78Steppage gait (HP:0003376)1.95045111
79Distal lower limb muscle weakness (HP:0009053)1.94362316
80Bradycardia (HP:0001662)1.93966157
81Abnormality of alanine metabolism (HP:0010916)1.92265578
82Hyperalaninemia (HP:0003348)1.92265578
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92265578
84Muscle stiffness (HP:0003552)1.92231827
85Congestive heart failure (HP:0001635)1.90306367
86Acute encephalopathy (HP:0006846)1.89878060
87Vascular tortuosity (HP:0004948)1.89440661
88Progressive macrocephaly (HP:0004481)1.88794029
89Arterial tortuosity (HP:0005116)1.88710586
90Neuroendocrine neoplasm (HP:0100634)1.88079572
91Gowers sign (HP:0003391)1.85888396
92Neoplasm of the adrenal gland (HP:0100631)1.84725102
93Foot dorsiflexor weakness (HP:0009027)1.84124851
94Abnormality of skeletal muscle fiber size (HP:0012084)1.83038212
95Ketosis (HP:0001946)1.82805314
96Hepatocellular necrosis (HP:0001404)1.81981453
97Type 1 muscle fiber predominance (HP:0003803)1.81882838
98Scotoma (HP:0000575)1.80293919
99Insulin-resistant diabetes mellitus (HP:0000831)1.79486476
100Lower limb amyotrophy (HP:0007210)1.79165030
101Muscular dystrophy (HP:0003560)1.77633405
102Double outlet right ventricle (HP:0001719)1.77424854
103Congenital malformation of the right heart (HP:0011723)1.77424854
104Abnormality of fatty-acid metabolism (HP:0004359)1.76914946
105Scapular winging (HP:0003691)1.75774176
106Mildly elevated creatine phosphokinase (HP:0008180)1.75465206
107Abnormality of the ischium (HP:0003174)1.75353424
108Dicarboxylic aciduria (HP:0003215)1.74071535
109Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74071535
110Increased muscle lipid content (HP:0009058)1.73911245
111Frequent falls (HP:0002359)1.73348392
112Lymphangioma (HP:0100764)1.71960519
113Waddling gait (HP:0002515)1.71850314
114Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70266644
115Athetosis (HP:0002305)1.68819055
116Abnormality of the tricuspid valve (HP:0001702)1.68347514
117Tinnitus (HP:0000360)1.67400830
118Preauricular pit (HP:0004467)1.66725038
119Periauricular skin pits (HP:0100277)1.66725038
120Rimmed vacuoles (HP:0003805)1.65781285
121Skin pits (HP:0100276)1.65753273
122Distal lower limb amyotrophy (HP:0008944)1.64561793
123Mitochondrial inheritance (HP:0001427)1.63987089
124Cerebral edema (HP:0002181)1.63375600
125Proximal amyotrophy (HP:0007126)1.62522390
126Calcaneovalgus deformity (HP:0001848)1.62147857
127Increased CSF lactate (HP:0002490)1.59830873
128Ulnar deviation of the wrist (HP:0003049)1.59671420
129Generalized muscle weakness (HP:0003324)1.58848821
130Limb-girdle muscle weakness (HP:0003325)1.58682294
131Turricephaly (HP:0000262)1.58114810
132Anomalous pulmonary venous return (HP:0010772)1.51299622
133Absent phalangeal crease (HP:0006109)1.51160648
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.47225192
135Deformed tarsal bones (HP:0008119)1.44003576
136Skin nodule (HP:0200036)1.43527982
137Aplasia of the musculature (HP:0100854)1.43104457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.59844834
2PHKG13.65931276
3PHKG23.65931276
4LMTK23.56843244
5DMPK3.41842725
6OBSCN3.41481246
7MYLK3.26761690
8PDK42.99095826
9PDK32.99095826
10PKN22.83507603
11TRIB32.48183621
12NEK12.30444793
13MUSK2.23866292
14EPHB22.20515544
15LATS22.09779099
16STK38L2.04437228
17LATS12.00367207
18STK241.97911336
19PIK3CA1.97562634
20PINK11.86873144
21PAK31.70091043
22PDK21.58863902
23STK381.49544459
24NEK91.47945499
25PRKD31.47034721
26LIMK11.41808836
27MAP3K41.41251256
28TIE11.39385857
29KSR21.30458433
30WNK41.30006778
31PAK61.26767864
32BCKDK1.24508539
33CAMK2D1.23332285
34MAP3K91.22918378
35TAOK11.21788018
36PRKD11.19285683
37CDC42BPA1.18914711
38MAP3K61.17257146
39PRKAA11.13334108
40ILK1.11311447
41CASK1.11014881
42MAP3K51.10610354
43GRK71.08122794
44ROCK11.01931189
45NTRK10.99030528
46RIPK10.95107384
47DDR20.93926732
48NTRK20.92467143
49INSRR0.87651679
50PTK20.87271884
51PDGFRA0.86231824
52CAMK2A0.84242209
53PRKAA20.83814051
54MAP3K70.83507247
55MAPKAPK30.81031504
56MAP2K40.80095183
57MAPK70.78807946
58RET0.75610385
59MAPK120.74470251
60CAMK2B0.73166525
61PIK3CG0.71912031
62CAMK40.68503740
63PAK20.66612549
64MARK10.65107979
65WNK10.65023476
66TNIK0.63925857
67ARAF0.63236111
68UHMK10.62963752
69MET0.62645379
70MAP3K100.61838773
71CAMK10.59718064
72CDK50.54757197
73STK40.53969573
74DAPK30.53349075
75MAPK40.53230849
76ROCK20.52925876
77PRKCH0.52111639
78SGK30.50125981
79AKT30.49868781
80PKN10.49060676
81MOS0.47168984
82MAPKAPK50.46600375
83KSR10.46382476
84SGK20.44518232
85PRKACB0.44274214
86PDPK10.43699473
87CCNB10.43678385
88RAF10.42876200
89PRKCE0.42205314
90MARK20.42073940
91PRKD20.41955772
92PRKG10.41655103
93CDK80.41649078
94RPS6KA60.40723347
95MAP2K70.39921641
96EEF2K0.39499725
97TRPM70.39359914
98PRKACA0.37662145
99STK110.37033018
100CAMK1D0.36522728
101NTRK30.36142629
102SGK4940.35948071
103SGK2230.35948071
104DYRK1B0.35395500
105PDK10.34906888
106PTK2B0.34520114
107ZAK0.34199166
108SGK10.33778641
109MELK0.32859969
110TYRO30.30619260
111CAMK2G0.30380324
112MAP3K10.30211252
113FLT30.29835356
114ICK0.29208052
115PRKACG0.29162602
116RPS6KA30.28894662
117FER0.27487114
118CAMKK10.26313813
119STK390.26280557
120MTOR0.24864818
121AKT20.23581660
122RPS6KC10.23033141
123RPS6KL10.23033141
124ERBB40.21457517
125CAMK1G0.21020456
126RPS6KA20.20675850
127RPS6KA10.19472948
128EPHA40.19045555
129STK30.18236480
130HIPK20.17967688

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.18322295
2Cardiac muscle contraction_Homo sapiens_hsa042604.01353545
3Dilated cardiomyopathy_Homo sapiens_hsa054143.79048127
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.58216355
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.55033456
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73367536
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.51514664
8Propanoate metabolism_Homo sapiens_hsa006402.42214981
9Parkinsons disease_Homo sapiens_hsa050122.27553011
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.21826038
11Oxidative phosphorylation_Homo sapiens_hsa001902.16921385
12Fatty acid degradation_Homo sapiens_hsa000712.04064165
13Carbon metabolism_Homo sapiens_hsa012001.84688405
14Alzheimers disease_Homo sapiens_hsa050101.74186348
15Huntingtons disease_Homo sapiens_hsa050161.57525052
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53937411
17Fatty acid metabolism_Homo sapiens_hsa012121.53492902
18Viral myocarditis_Homo sapiens_hsa054161.44998410
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40265980
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.38947955
21Pyruvate metabolism_Homo sapiens_hsa006201.36025224
22Glucagon signaling pathway_Homo sapiens_hsa049221.25890945
23Insulin secretion_Homo sapiens_hsa049111.23392776
24Butanoate metabolism_Homo sapiens_hsa006501.21887821
25Type II diabetes mellitus_Homo sapiens_hsa049301.17661056
26Oxytocin signaling pathway_Homo sapiens_hsa049211.12440808
27Circadian rhythm_Homo sapiens_hsa047101.12410778
28Insulin resistance_Homo sapiens_hsa049311.10492693
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07335536
30Insulin signaling pathway_Homo sapiens_hsa049101.06065739
31Axon guidance_Homo sapiens_hsa043601.04171211
32Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99895386
33Calcium signaling pathway_Homo sapiens_hsa040200.99660149
34Circadian entrainment_Homo sapiens_hsa047130.99578762
35Hippo signaling pathway_Homo sapiens_hsa043900.99146267
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97525410
37Hedgehog signaling pathway_Homo sapiens_hsa043400.97244336
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.96823547
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95178194
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93917567
41Gastric acid secretion_Homo sapiens_hsa049710.91114151
42cAMP signaling pathway_Homo sapiens_hsa040240.89934326
43Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89305023
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87556500
45Basal cell carcinoma_Homo sapiens_hsa052170.87432139
46Renin secretion_Homo sapiens_hsa049240.87131332
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.85943816
48AMPK signaling pathway_Homo sapiens_hsa041520.85041112
49Ovarian steroidogenesis_Homo sapiens_hsa049130.83044091
50GnRH signaling pathway_Homo sapiens_hsa049120.82393031
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81663340
52Biosynthesis of amino acids_Homo sapiens_hsa012300.79591964
53Olfactory transduction_Homo sapiens_hsa047400.79497688
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78522339
55Dorso-ventral axis formation_Homo sapiens_hsa043200.78318595
56Cholinergic synapse_Homo sapiens_hsa047250.78252816
57Focal adhesion_Homo sapiens_hsa045100.76984251
58Lysine degradation_Homo sapiens_hsa003100.76917408
59Tight junction_Homo sapiens_hsa045300.75315607
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73591769
61Proteoglycans in cancer_Homo sapiens_hsa052050.73247969
62Long-term potentiation_Homo sapiens_hsa047200.72070940
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68969178
64Protein digestion and absorption_Homo sapiens_hsa049740.68274880
65Wnt signaling pathway_Homo sapiens_hsa043100.66631266
66Dopaminergic synapse_Homo sapiens_hsa047280.64573551
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63880458
68mTOR signaling pathway_Homo sapiens_hsa041500.62977359
69Renal cell carcinoma_Homo sapiens_hsa052110.62152204
70HIF-1 signaling pathway_Homo sapiens_hsa040660.61468560
71Nicotine addiction_Homo sapiens_hsa050330.61442392
72Taste transduction_Homo sapiens_hsa047420.60381552
73Bile secretion_Homo sapiens_hsa049760.59606769
74Adherens junction_Homo sapiens_hsa045200.59502981
75Gap junction_Homo sapiens_hsa045400.58307449
76Estrogen signaling pathway_Homo sapiens_hsa049150.57857918
77PPAR signaling pathway_Homo sapiens_hsa033200.56859152
78Amphetamine addiction_Homo sapiens_hsa050310.56376058
79GABAergic synapse_Homo sapiens_hsa047270.55893953
80Morphine addiction_Homo sapiens_hsa050320.55656506
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.55430682
82Thyroid hormone synthesis_Homo sapiens_hsa049180.55187861
83Glutamatergic synapse_Homo sapiens_hsa047240.55127592
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54945087
85Starch and sucrose metabolism_Homo sapiens_hsa005000.52415994
86Phenylalanine metabolism_Homo sapiens_hsa003600.52266755
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52249092
88Salivary secretion_Homo sapiens_hsa049700.51967543
89TGF-beta signaling pathway_Homo sapiens_hsa043500.51625802
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49218789
91Fatty acid elongation_Homo sapiens_hsa000620.46750843
92Arginine biosynthesis_Homo sapiens_hsa002200.46653196
93Phototransduction_Homo sapiens_hsa047440.45674291
94Small cell lung cancer_Homo sapiens_hsa052220.44459116
95VEGF signaling pathway_Homo sapiens_hsa043700.42224153
96Oocyte meiosis_Homo sapiens_hsa041140.42117524
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41796097
98Pathways in cancer_Homo sapiens_hsa052000.41503195
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40748616
100Melanoma_Homo sapiens_hsa052180.40608272
101Melanogenesis_Homo sapiens_hsa049160.39902285
102Synaptic vesicle cycle_Homo sapiens_hsa047210.39297619
103Prion diseases_Homo sapiens_hsa050200.38537121
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38018543
105Endometrial cancer_Homo sapiens_hsa052130.37935337
106Serotonergic synapse_Homo sapiens_hsa047260.37625115
107ECM-receptor interaction_Homo sapiens_hsa045120.37622200
108Long-term depression_Homo sapiens_hsa047300.37320133
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37234344
110Rap1 signaling pathway_Homo sapiens_hsa040150.36463750
111Amoebiasis_Homo sapiens_hsa051460.35898684
112Tryptophan metabolism_Homo sapiens_hsa003800.35467327
113Pancreatic secretion_Homo sapiens_hsa049720.35431326
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33564622
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.33119887
116Arginine and proline metabolism_Homo sapiens_hsa003300.32493284
117MAPK signaling pathway_Homo sapiens_hsa040100.31556193
118Fatty acid biosynthesis_Homo sapiens_hsa000610.31534331
119Cocaine addiction_Homo sapiens_hsa050300.31048370
120Glioma_Homo sapiens_hsa052140.30952112
121FoxO signaling pathway_Homo sapiens_hsa040680.28332827
122Galactose metabolism_Homo sapiens_hsa000520.27813249
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27044363

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