FHP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.62986721
2establishment of protein localization to mitochondrial membrane (GO:0090151)7.23037335
3translational termination (GO:0006415)7.21610231
4ribosomal small subunit assembly (GO:0000028)7.06878301
5ribosomal small subunit biogenesis (GO:0042274)6.93729919
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.28041077
7ATP synthesis coupled proton transport (GO:0015986)6.22364022
8energy coupled proton transport, down electrochemical gradient (GO:0015985)6.22364022
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.89721760
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.89509865
11protein targeting to ER (GO:0045047)5.85105100
12cotranslational protein targeting to membrane (GO:0006613)5.79859052
13translational elongation (GO:0006414)5.78458830
14maturation of SSU-rRNA (GO:0030490)5.72713331
15behavioral response to nicotine (GO:0035095)5.72298898
16establishment of protein localization to endoplasmic reticulum (GO:0072599)5.58758579
17viral life cycle (GO:0019058)5.54474516
18cellular protein complex disassembly (GO:0043624)5.53569382
19protein localization to endoplasmic reticulum (GO:0070972)5.45906390
20pyrimidine nucleotide catabolic process (GO:0006244)5.33093495
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.24167593
22glyoxylate metabolic process (GO:0046487)5.10398367
23protein polyglutamylation (GO:0018095)4.88540733
24translational initiation (GO:0006413)4.79335409
25protein complex disassembly (GO:0043241)4.68921246
26chaperone-mediated protein transport (GO:0072321)4.44955240
27macromolecular complex disassembly (GO:0032984)4.44694176
28protein complex biogenesis (GO:0070271)4.03099300
29pyrimidine nucleobase catabolic process (GO:0006208)3.84923568
30protein targeting to membrane (GO:0006612)3.83225125
31base-excision repair, AP site formation (GO:0006285)3.81990392
32regulation of cilium movement (GO:0003352)3.79693609
33preassembly of GPI anchor in ER membrane (GO:0016254)3.79462310
34pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.70326539
35electron transport chain (GO:0022900)3.66127095
36respiratory electron transport chain (GO:0022904)3.59168148
37mitochondrial respiratory chain complex assembly (GO:0033108)3.58199661
38ATP biosynthetic process (GO:0006754)3.55120686
39heterochromatin organization (GO:0070828)3.54472953
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52224025
41substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.48729318
42substrate-independent telencephalic tangential migration (GO:0021826)3.48729318
43positive regulation of protein homooligomerization (GO:0032464)3.46848534
44receptor guanylyl cyclase signaling pathway (GO:0007168)3.46641953
45translation (GO:0006412)3.40687525
46regulation of microtubule-based movement (GO:0060632)3.37187495
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36209797
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.36209797
49NADH dehydrogenase complex assembly (GO:0010257)3.36209797
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.30256991
51ribosomal large subunit biogenesis (GO:0042273)3.29920719
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27623792
53dopamine biosynthetic process (GO:0042416)3.25370822
54neuron fate determination (GO:0048664)3.25320615
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25131593
56chaperone-mediated protein complex assembly (GO:0051131)3.25127240
57male meiosis I (GO:0007141)3.25065816
58sequestering of actin monomers (GO:0042989)3.22451731
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21485197
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21485197
61purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16532029
62negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.12944600
63mRNA catabolic process (GO:0006402)3.09111828
64negative regulation of telomere maintenance (GO:0032205)3.07191832
65negative regulation of potassium ion transmembrane transport (GO:1901380)3.04595245
66peptidyl-histidine modification (GO:0018202)3.01652481
67protein neddylation (GO:0045116)3.00562504
68cell proliferation in forebrain (GO:0021846)2.99255395
69somite development (GO:0061053)2.98995808
70behavioral fear response (GO:0001662)2.98614241
71behavioral defense response (GO:0002209)2.98614241
72serine family amino acid catabolic process (GO:0009071)2.96103776
73ribonucleoside triphosphate biosynthetic process (GO:0009201)2.94865874
74nucleobase catabolic process (GO:0046113)2.93883913
75negative regulation of multicellular organism growth (GO:0040015)2.91471541
76hydrogen ion transmembrane transport (GO:1902600)2.90237548
77deoxyribonucleotide catabolic process (GO:0009264)2.82641276
78intracellular protein transmembrane import (GO:0044743)2.82065269
79positive regulation of sodium ion transmembrane transport (GO:1902307)2.79583685
80ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.79250955
81negative regulation of response to food (GO:0032096)2.78069200
82negative regulation of appetite (GO:0032099)2.78069200
83axonemal dynein complex assembly (GO:0070286)2.77832092
84resolution of meiotic recombination intermediates (GO:0000712)2.76088325
85transmission of nerve impulse (GO:0019226)2.75590731
86RNA catabolic process (GO:0006401)2.74411982
87positive regulation of respiratory burst (GO:0060267)2.74211006
88intraciliary transport (GO:0042073)2.70611610
89tongue development (GO:0043586)2.70371087
90auditory receptor cell differentiation (GO:0042491)2.70064859
91nonmotile primary cilium assembly (GO:0035058)2.69858469
92water-soluble vitamin biosynthetic process (GO:0042364)2.69461839
93phenol-containing compound catabolic process (GO:0019336)2.65066358
94fear response (GO:0042596)2.64830630
95regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.63782371
96axonal fasciculation (GO:0007413)2.63049335
97regulation of mitochondrial translation (GO:0070129)2.62976858
98establishment of protein localization to membrane (GO:0090150)2.61304251
99cellular component biogenesis (GO:0044085)2.60814101
100icosanoid secretion (GO:0032309)2.60174659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.21614754
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49158758
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.42354160
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.36530931
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.01971867
6ZNF274_21170338_ChIP-Seq_K562_Hela2.55139352
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.45011156
8IRF1_19129219_ChIP-ChIP_H3396_Human2.42965561
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.38597945
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.36852994
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.30373900
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30013997
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25766721
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.19071972
15REST_21632747_ChIP-Seq_MESCs_Mouse2.04721778
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97051944
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95763142
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.92505851
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89975852
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.87562735
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83175586
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75937472
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72589761
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72589761
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.72143979
26RNF2_27304074_Chip-Seq_NSC_Mouse1.69228772
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64326531
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64070536
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63804890
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63045639
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59617957
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.56984837
33P53_22127205_ChIP-Seq_FIBROBLAST_Human1.50369247
34TP53_22573176_ChIP-Seq_HFKS_Human1.46308217
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.44071059
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43445991
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43232518
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.41693424
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38723827
40SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38110366
41E2F1_20622854_ChIP-Seq_HELA_Human1.37170258
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.36221042
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33975567
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33966664
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31939499
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30202067
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30011828
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28551484
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26365336
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.24779540
51CTCF_27219007_Chip-Seq_Bcells_Human1.23607473
52SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22150774
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.18372924
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.17450104
55ERA_21632823_ChIP-Seq_H3396_Human1.16247321
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16075193
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15370323
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11710643
59NANOG_20526341_ChIP-Seq_ESCs_Human1.11040174
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10555370
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.08344584
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07962543
63RAC3_21632823_ChIP-Seq_H3396_Human1.07706467
64P300_27268052_Chip-Seq_Bcells_Human1.07103598
65VDR_22108803_ChIP-Seq_LS180_Human1.07058614
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06106214
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04868344
68OCT4_19829295_ChIP-Seq_ESCs_Human1.03768685
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03254100
70EWS_26573619_Chip-Seq_HEK293_Human1.02995940
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02838389
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02728672
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.02631823
74BCL6_27268052_Chip-Seq_Bcells_Human1.02498603
75TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00991922
76TAF2_19829295_ChIP-Seq_ESCs_Human1.00161981
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00020172
78P53_21459846_ChIP-Seq_SAOS-2_Human0.98577621
79CTCF_20526341_ChIP-Seq_ESCs_Human0.97991874
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97850429
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93708050
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93033638
83P68_20966046_ChIP-Seq_HELA_Human0.91412762
84P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91003177
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90562969
86CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90544126
87ER_23166858_ChIP-Seq_MCF-7_Human0.87985337
88FOXH1_21741376_ChIP-Seq_ESCs_Human0.87467075
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84383378
90FUS_26573619_Chip-Seq_HEK293_Human0.83322192
91P300_19829295_ChIP-Seq_ESCs_Human0.83195571
92BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.82890330
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82343044
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.82183127
95DROSHA_22980978_ChIP-Seq_HELA_Human0.81915962
96NCOR_22424771_ChIP-Seq_293T_Human0.80172221
97BCOR_27268052_Chip-Seq_Bcells_Human0.79984754
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79085620
99MYC_19829295_ChIP-Seq_ESCs_Human0.78868350
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.78115584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.19466289
2MP0003646_muscle_fatigue4.68357678
3MP0006292_abnormal_olfactory_placode3.56713678
4MP0003122_maternal_imprinting3.44949043
5MP0008789_abnormal_olfactory_epithelium3.32664655
6MP0005394_taste/olfaction_phenotype2.92433338
7MP0005499_abnormal_olfactory_system2.92433338
8MP0002653_abnormal_ependyma_morphology2.74713230
9MP0003123_paternal_imprinting2.32677277
10MP0002837_dystrophic_cardiac_calcinosis2.17915821
11MP0003121_genomic_imprinting2.13988384
12MP0004145_abnormal_muscle_electrophysio2.13637472
13MP0000778_abnormal_nervous_system1.90798058
14MP0006276_abnormal_autonomic_nervous1.88226340
15MP0001485_abnormal_pinna_reflex1.84646422
16MP0005670_abnormal_white_adipose1.84598371
17MP0001440_abnormal_grooming_behavior1.80151171
18MP0002736_abnormal_nociception_after1.77417768
19MP0003787_abnormal_imprinting1.76948781
20MP0002160_abnormal_reproductive_system1.72081016
21MP0005423_abnormal_somatic_nervous1.69111888
22MP0003011_delayed_dark_adaptation1.62079962
23MP0004885_abnormal_endolymph1.60309161
24MP0004142_abnormal_muscle_tone1.57565447
25MP0002876_abnormal_thyroid_physiology1.57350587
26MP0001968_abnormal_touch/_nociception1.56374026
27MP0004133_heterotaxia1.56029395
28MP0001529_abnormal_vocalization1.55649545
29MP0000566_synostosis1.53509420
30MP0003880_abnormal_central_pattern1.50907576
31MP0003879_abnormal_hair_cell1.49000155
32MP0001293_anophthalmia1.48814966
33MP0002163_abnormal_gland_morphology1.48488928
34MP0000049_abnormal_middle_ear1.47437467
35MP0003890_abnormal_embryonic-extraembry1.45642395
36MP0005377_hearing/vestibular/ear_phenot1.44071569
37MP0003878_abnormal_ear_physiology1.44071569
38MP0002735_abnormal_chemical_nociception1.42227574
39MP0010030_abnormal_orbit_morphology1.41994496
40MP0003941_abnormal_skin_development1.39810239
41MP0001919_abnormal_reproductive_system1.37652998
42MP0000631_abnormal_neuroendocrine_gland1.37527344
43MP0002272_abnormal_nervous_system1.36189964
44MP0003938_abnormal_ear_development1.32690626
45MP0001486_abnormal_startle_reflex1.32040771
46MP0004043_abnormal_pH_regulation1.31019343
47MP0003136_yellow_coat_color1.30681575
48MP0004858_abnormal_nervous_system1.27983107
49MP0004742_abnormal_vestibular_system1.27664028
50MP0002233_abnormal_nose_morphology1.24533337
51MP0009053_abnormal_anal_canal1.23998244
52MP0002234_abnormal_pharynx_morphology1.23266228
53MP0002184_abnormal_innervation1.22893742
54MP0005389_reproductive_system_phenotype1.21528033
55MP0000955_abnormal_spinal_cord1.15297196
56MP0002638_abnormal_pupillary_reflex1.14964574
57MP0002557_abnormal_social/conspecific_i1.12271726
58MP0005551_abnormal_eye_electrophysiolog1.12106278
59MP0003119_abnormal_digestive_system1.11070207
60MP0000026_abnormal_inner_ear1.07189617
61MP0002102_abnormal_ear_morphology1.06829907
62MP0009745_abnormal_behavioral_response1.05711110
63MP0002733_abnormal_thermal_nociception1.02288360
64MP0002095_abnormal_skin_pigmentation1.01721955
65MP0002752_abnormal_somatic_nervous1.01692918
66MP0001986_abnormal_taste_sensitivity0.98613885
67MP0001970_abnormal_pain_threshold0.97479874
68MP0005195_abnormal_posterior_eye0.96891200
69MP0005646_abnormal_pituitary_gland0.96079683
70MP0006072_abnormal_retinal_apoptosis0.95878334
71MP0009046_muscle_twitch0.94775411
72MP0002063_abnormal_learning/memory/cond0.94526048
73MP0004859_abnormal_synaptic_plasticity0.93380974
74MP0002277_abnormal_respiratory_mucosa0.92549413
75MP0003635_abnormal_synaptic_transmissio0.92406222
76MP0002928_abnormal_bile_duct0.91727231
77MP0004130_abnormal_muscle_cell0.91580342
78MP0001905_abnormal_dopamine_level0.90768425
79MP0002734_abnormal_mechanical_nocicepti0.90439636
80MP0002572_abnormal_emotion/affect_behav0.89721468
81MP0003959_abnormal_lean_body0.86067866
82MP0010386_abnormal_urinary_bladder0.85109953
83MP0001984_abnormal_olfaction0.84911573
84MP0002882_abnormal_neuron_morphology0.80984027
85MP0002064_seizures0.80665615
86MP0003942_abnormal_urinary_system0.78877875
87MP0002909_abnormal_adrenal_gland0.77798329
88MP0008872_abnormal_physiological_respon0.77363698
89MP0002210_abnormal_sex_determination0.76952533
90MP0008057_abnormal_DNA_replication0.76828641
91MP0008058_abnormal_DNA_repair0.74077381
92MP0005645_abnormal_hypothalamus_physiol0.74075717
93MP0001963_abnormal_hearing_physiology0.73436693
94MP0009250_abnormal_appendicular_skeleto0.72018004
95MP0002067_abnormal_sensory_capabilities0.71929859
96MP0003137_abnormal_impulse_conducting0.71809545
97MP0003937_abnormal_limbs/digits/tail_de0.71535811
98MP0008775_abnormal_heart_ventricle0.70191693
99MP0002249_abnormal_larynx_morphology0.69299045
100MP0002152_abnormal_brain_morphology0.68588573

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.05176905
2Lipid accumulation in hepatocytes (HP:0006561)4.59331065
3Abnormality of cells of the erythroid lineage (HP:0012130)4.53884051
4Colon cancer (HP:0003003)3.82014608
5Rib fusion (HP:0000902)3.80370990
6Macrocytic anemia (HP:0001972)3.59012008
7Pallor (HP:0000980)3.57941773
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.46409142
9Hip dysplasia (HP:0001385)3.44880100
10Abnormal number of erythroid precursors (HP:0012131)3.27884024
11Increased muscle lipid content (HP:0009058)3.25708073
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.20876793
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.04084171
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.04084171
15Increased hepatocellular lipid droplets (HP:0006565)3.03912350
16Myokymia (HP:0002411)3.01759784
17Absent thumb (HP:0009777)2.95990685
18Methylmalonic aciduria (HP:0012120)2.90303200
19Type II lissencephaly (HP:0007260)2.89408594
20Hyperthyroidism (HP:0000836)2.83765675
21Abnormal rod and cone electroretinograms (HP:0008323)2.82236617
22Nephrogenic diabetes insipidus (HP:0009806)2.73153664
23Mitochondrial inheritance (HP:0001427)2.72443882
24Tubulointerstitial nephritis (HP:0001970)2.70067430
25Renal Fanconi syndrome (HP:0001994)2.69510840
26Methylmalonic acidemia (HP:0002912)2.67791251
27Panhypogammaglobulinemia (HP:0003139)2.63265425
28Acute necrotizing encephalopathy (HP:0006965)2.61871859
29Abnormality of midbrain morphology (HP:0002418)2.61248576
30Molar tooth sign on MRI (HP:0002419)2.61248576
31Medial flaring of the eyebrow (HP:0010747)2.54068409
32Asplenia (HP:0001746)2.53879130
33Pendular nystagmus (HP:0012043)2.51573636
34Abnormal mitochondria in muscle tissue (HP:0008316)2.50377239
35Supernumerary spleens (HP:0009799)2.48083673
36Nephronophthisis (HP:0000090)2.47127290
37Acute encephalopathy (HP:0006846)2.47025621
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.39135599
39Anomalous pulmonary venous return (HP:0010772)2.38371495
40Septo-optic dysplasia (HP:0100842)2.37568666
41Gait imbalance (HP:0002141)2.34137752
42Hepatocellular necrosis (HP:0001404)2.33544888
43Increased intramyocellular lipid droplets (HP:0012240)2.28776635
44Abnormality of the diencephalon (HP:0010662)2.27271767
45Broad distal phalanx of finger (HP:0009836)2.25743070
46Hepatic necrosis (HP:0002605)2.22284299
47Increased CSF lactate (HP:0002490)2.22261740
48Neoplasm of head and neck (HP:0012288)2.22015633
49Esophageal neoplasm (HP:0100751)2.22015633
50Congenital primary aphakia (HP:0007707)2.17777181
51Respiratory difficulties (HP:0002880)2.16456064
52Bony spicule pigmentary retinopathy (HP:0007737)2.13617019
53Abnormality of renal resorption (HP:0011038)2.13267560
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11638906
55Hyperglycinemia (HP:0002154)2.11288274
56Stenosis of the external auditory canal (HP:0000402)2.09174172
57Abnormal respiratory motile cilium physiology (HP:0012261)2.08826300
58Partial duplication of thumb phalanx (HP:0009944)2.08825467
59Poor coordination (HP:0002370)2.08181981
60Abnormal respiratory motile cilium morphology (HP:0005938)2.06921268
61Abnormal respiratory epithelium morphology (HP:0012253)2.06921268
62Abnormal ciliary motility (HP:0012262)2.06477860
63Cerebellar dysplasia (HP:0007033)2.05529530
64Cerebral hypomyelination (HP:0006808)2.05120105
65Abnormality of the pulmonary veins (HP:0011718)2.04099946
66True hermaphroditism (HP:0010459)2.00173005
67Progressive macrocephaly (HP:0004481)1.99460911
68Enlarged kidneys (HP:0000105)1.99278732
69Abnormality of the renal medulla (HP:0100957)1.96958153
70Pachygyria (HP:0001302)1.94870272
71Polyphagia (HP:0002591)1.94748103
72Pancreatic fibrosis (HP:0100732)1.94074362
73Congenital stationary night blindness (HP:0007642)1.93980543
74Sleep apnea (HP:0010535)1.92946502
75Pancreatic cysts (HP:0001737)1.92635130
76Confusion (HP:0001289)1.91319806
77Absent/shortened dynein arms (HP:0200106)1.90137626
78Dynein arm defect of respiratory motile cilia (HP:0012255)1.90137626
79Hypoplasia of the radius (HP:0002984)1.89980248
80Dicarboxylic aciduria (HP:0003215)1.88633368
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88633368
82Hypoplasia of the ulna (HP:0003022)1.88369709
83Lissencephaly (HP:0001339)1.84390043
84Symphalangism affecting the phalanges of the hand (HP:0009773)1.83851067
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.83445240
86Short femoral neck (HP:0100864)1.81899438
87Sclerocornea (HP:0000647)1.81850738
88Exertional dyspnea (HP:0002875)1.80447721
893-Methylglutaconic aciduria (HP:0003535)1.78784585
90Abnormality of the phalanges of the 5th finger (HP:0004213)1.78503859
91Anencephaly (HP:0002323)1.78300624
92Abnormality of the aortic arch (HP:0012303)1.77620188
93Glycosuria (HP:0003076)1.76746047
94Abnormality of urine glucose concentration (HP:0011016)1.76746047
95Chorioretinal atrophy (HP:0000533)1.76434902
96Depressed nasal ridge (HP:0000457)1.75281460
97Specific learning disability (HP:0001328)1.73439413
98Elfin facies (HP:0004428)1.72989562
99Partial duplication of the phalanx of hand (HP:0009999)1.72522398
100Forearm undergrowth (HP:0009821)1.71797119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.11492547
2WNK43.35957051
3DYRK22.95274843
4ADRBK22.66568178
5CDC72.23979450
6CASK2.15424328
7MAP2K22.14593717
8TIE11.93284179
9MAP2K71.84603730
10LRRK21.84455945
11STK391.77690355
12PIK3CA1.77261143
13STK111.74512199
14DAPK21.71165902
15WNK31.69444916
16EPHB21.67276367
17VRK21.61982953
18ZAK1.59516167
19TRIM281.58192442
20MINK11.41126409
21NEK21.40743628
22MARK11.40021818
23PINK11.39472857
24GRK11.39379931
25MUSK1.35471841
26BMPR1B1.34668249
27MAPK131.25607266
28PRKCG1.23917560
29PDK21.21106532
30NEK11.17849252
31MAPK151.17629179
32CSNK1G21.17333829
33FRK1.16646795
34NLK1.15790115
35MAP3K41.15145559
36DYRK31.13729489
37SIK21.12256343
38NME11.06983286
39RPS6KA21.06048306
40ADRBK11.02991460
41NTRK20.99594683
42MARK20.98037479
43MAP3K90.95960065
44BCKDK0.92043847
45CSNK1E0.90297467
46CSNK1G30.89603327
47DYRK1A0.84113836
48CDK190.82026072
49CAMKK10.81178537
50INSRR0.78165242
51CAMKK20.78031139
52MAP2K10.76177923
53TXK0.75997859
54WNK10.74624716
55TAF10.74464022
56CSNK1A1L0.73701524
57IRAK20.73422820
58EPHA40.72442568
59CAMK10.70311914
60PAK30.70162846
61RPS6KA50.70039635
62DAPK30.69989084
63MAP2K40.68367421
64RPS6KA60.68356463
65LIMK10.68188279
66ATR0.65024943
67MAP3K80.64876172
68DYRK1B0.64673666
69PRKACA0.63835758
70PRKCZ0.63377965
71PRKCH0.62435563
72PLK40.60558740
73CSNK2A20.60494154
74TAOK30.59797910
75IKBKE0.59669169
76CAMK40.58341130
77CDK80.57901687
78PLK10.54532858
79CSNK1A10.54395691
80PRKCI0.54276194
81SGK2230.53728416
82SGK4940.53728416
83TESK20.53294066
84CAMK2A0.51824898
85RPS6KL10.50885667
86RPS6KC10.50885667
87OBSCN0.50136101
88PRKCQ0.49207009
89RPS6KB10.46757976
90VRK10.46388080
91PRKCA0.45450673
92CSNK2A10.45157295
93CSNK1G10.43377370
94MELK0.41231642
95PRKCD0.41083038
96GRK50.40792391
97AURKA0.40223706
98SGK20.39622903
99NTRK30.38783632
100BRSK10.38687573

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.65788065
2Oxidative phosphorylation_Homo sapiens_hsa001904.38823563
3Parkinsons disease_Homo sapiens_hsa050123.72301999
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.06434495
5Cardiac muscle contraction_Homo sapiens_hsa042603.05555256
6Alzheimers disease_Homo sapiens_hsa050102.87098746
7Sulfur relay system_Homo sapiens_hsa041222.82131834
8Huntingtons disease_Homo sapiens_hsa050162.80073330
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11400244
10Nicotine addiction_Homo sapiens_hsa050332.07129510
11Phototransduction_Homo sapiens_hsa047441.74588501
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73511338
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60848135
14Olfactory transduction_Homo sapiens_hsa047401.60084593
15Fanconi anemia pathway_Homo sapiens_hsa034601.47029677
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42280496
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39910686
18Homologous recombination_Homo sapiens_hsa034401.38272775
19Asthma_Homo sapiens_hsa053101.35510829
20Steroid biosynthesis_Homo sapiens_hsa001001.28016981
21Morphine addiction_Homo sapiens_hsa050321.21976046
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19317427
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14336924
24Basal cell carcinoma_Homo sapiens_hsa052171.13898615
25GABAergic synapse_Homo sapiens_hsa047271.11859515
26Peroxisome_Homo sapiens_hsa041461.11342506
27Propanoate metabolism_Homo sapiens_hsa006401.10182112
28RNA polymerase_Homo sapiens_hsa030201.09202124
29Primary immunodeficiency_Homo sapiens_hsa053401.08243668
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07666924
31Linoleic acid metabolism_Homo sapiens_hsa005911.07471633
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06342132
33Synaptic vesicle cycle_Homo sapiens_hsa047211.05279918
34Collecting duct acid secretion_Homo sapiens_hsa049661.04378884
35Arginine and proline metabolism_Homo sapiens_hsa003300.99163079
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98024294
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.96845069
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94082121
39Hedgehog signaling pathway_Homo sapiens_hsa043400.94055894
40Serotonergic synapse_Homo sapiens_hsa047260.90600134
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90401878
42Protein export_Homo sapiens_hsa030600.89414941
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89331526
44Glutamatergic synapse_Homo sapiens_hsa047240.86904622
45Pyrimidine metabolism_Homo sapiens_hsa002400.83255957
46Insulin secretion_Homo sapiens_hsa049110.79795482
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78121954
48Tryptophan metabolism_Homo sapiens_hsa003800.77813950
49Retinol metabolism_Homo sapiens_hsa008300.76507348
50Base excision repair_Homo sapiens_hsa034100.76169957
51Pyruvate metabolism_Homo sapiens_hsa006200.75812147
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.75551641
53Circadian entrainment_Homo sapiens_hsa047130.71673618
54Dopaminergic synapse_Homo sapiens_hsa047280.71594558
55Graft-versus-host disease_Homo sapiens_hsa053320.70502708
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69413507
57Axon guidance_Homo sapiens_hsa043600.67646667
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.65198489
59Metabolic pathways_Homo sapiens_hsa011000.61948920
60DNA replication_Homo sapiens_hsa030300.61489761
61Chemical carcinogenesis_Homo sapiens_hsa052040.58058389
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55358044
63Arachidonic acid metabolism_Homo sapiens_hsa005900.55121106
64Autoimmune thyroid disease_Homo sapiens_hsa053200.54635287
65Allograft rejection_Homo sapiens_hsa053300.54304834
66Cholinergic synapse_Homo sapiens_hsa047250.53897428
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52804813
68Nitrogen metabolism_Homo sapiens_hsa009100.52727922
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52444540
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50997541
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49625979
72Caffeine metabolism_Homo sapiens_hsa002320.48720985
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.48060330
74Phenylalanine metabolism_Homo sapiens_hsa003600.46531293
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44929271
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44503689
77Type I diabetes mellitus_Homo sapiens_hsa049400.44268049
78Fat digestion and absorption_Homo sapiens_hsa049750.44153539
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44135685
80Fatty acid degradation_Homo sapiens_hsa000710.42486218
81Antigen processing and presentation_Homo sapiens_hsa046120.40316380
82Folate biosynthesis_Homo sapiens_hsa007900.38483445
83Rheumatoid arthritis_Homo sapiens_hsa053230.37275378
84Alcoholism_Homo sapiens_hsa050340.37026057
85Systemic lupus erythematosus_Homo sapiens_hsa053220.34564431
86Fatty acid biosynthesis_Homo sapiens_hsa000610.34425800
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.34071437
88Taste transduction_Homo sapiens_hsa047420.33374927
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.32829986
90Cocaine addiction_Homo sapiens_hsa050300.32810004
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30953401
92Glycerolipid metabolism_Homo sapiens_hsa005610.30719778
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30287678
94Purine metabolism_Homo sapiens_hsa002300.29499983
95Wnt signaling pathway_Homo sapiens_hsa043100.29143224
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28873086
97p53 signaling pathway_Homo sapiens_hsa041150.28796600
98Butanoate metabolism_Homo sapiens_hsa006500.28458164
99RNA degradation_Homo sapiens_hsa030180.28327830
100Notch signaling pathway_Homo sapiens_hsa043300.28083262

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