FIBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)6.75429194
2ATP synthesis coupled proton transport (GO:0015986)6.75429194
3galactose catabolic process (GO:0019388)6.60416904
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.60068170
5chaperone-mediated protein transport (GO:0072321)6.21811179
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.64281287
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.93424481
8respiratory electron transport chain (GO:0022904)4.87913062
9electron transport chain (GO:0022900)4.76113818
10viral transcription (GO:0019083)4.68089023
11regulation of mitochondrial translation (GO:0070129)4.47788765
12endosome to pigment granule transport (GO:0043485)4.31846748
13endosome to melanosome transport (GO:0035646)4.31846748
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.25206484
15establishment of integrated proviral latency (GO:0075713)4.23427824
16translational termination (GO:0006415)4.18497713
17response to misfolded protein (GO:0051788)4.03378723
18ribosomal small subunit biogenesis (GO:0042274)4.02609369
19galactose metabolic process (GO:0006012)4.00460784
20establishment of viral latency (GO:0019043)3.99458824
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.95856934
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.93160559
23NADH dehydrogenase complex assembly (GO:0010257)3.93160559
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93160559
25cotranslational protein targeting to membrane (GO:0006613)3.92910897
26aldehyde catabolic process (GO:0046185)3.92190573
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.91958652
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.90101686
29negative regulation of ligase activity (GO:0051352)3.90021938
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.90021938
31translational elongation (GO:0006414)3.89948035
32rRNA modification (GO:0000154)3.88047078
33protein targeting to ER (GO:0045047)3.85310135
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.83908787
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.83908787
36mitochondrial respiratory chain complex assembly (GO:0033108)3.82173770
37protein complex biogenesis (GO:0070271)3.79539262
38base-excision repair, AP site formation (GO:0006285)3.79482785
39monocyte chemotaxis (GO:0002548)3.79184506
40negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.77046684
41protein maturation by protein folding (GO:0022417)3.76523006
42protein targeting to mitochondrion (GO:0006626)3.74471452
43signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.70282342
44ribosomal small subunit assembly (GO:0000028)3.68546984
45protein localization to endoplasmic reticulum (GO:0070972)3.67813909
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65385205
47regulation of translational termination (GO:0006449)3.65310877
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.62752587
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.60256452
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.60256452
51interleukin-6-mediated signaling pathway (GO:0070102)3.58511799
52establishment of protein localization to mitochondrion (GO:0072655)3.57890970
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.56253275
54negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.55566122
55viral life cycle (GO:0019058)3.53947033
56eosinophil chemotaxis (GO:0048245)3.53766106
57proteasome assembly (GO:0043248)3.51756118
58protein localization to mitochondrion (GO:0070585)3.42777137
59iron-sulfur cluster assembly (GO:0016226)3.42377712
60metallo-sulfur cluster assembly (GO:0031163)3.42377712
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.42122383
62cellular component biogenesis (GO:0044085)3.39644627
63protein neddylation (GO:0045116)3.33712481
64pseudouridine synthesis (GO:0001522)3.32715749
65hydrogen ion transmembrane transport (GO:1902600)3.32113742
66cellular protein complex disassembly (GO:0043624)3.30217536
67fat-soluble vitamin catabolic process (GO:0042363)3.29199279
68vitamin catabolic process (GO:0009111)3.29199279
69negative regulation of DNA-templated transcription, elongation (GO:0032785)3.27157600
70telomere maintenance via semi-conservative replication (GO:0032201)3.26950408
71positive regulation of ligase activity (GO:0051351)3.23940159
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.23500312
73eosinophil migration (GO:0072677)3.23014947
74ATP biosynthetic process (GO:0006754)3.22790987
75antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.16527533
76transcription-coupled nucleotide-excision repair (GO:0006283)3.15976688
77maturation of SSU-rRNA (GO:0030490)3.15670112
78purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14958897
79ribonucleoprotein complex biogenesis (GO:0022613)3.13501138
80oligosaccharide biosynthetic process (GO:0009312)3.13322713
81deoxyribonucleotide catabolic process (GO:0009264)3.11208317
82nuclear envelope reassembly (GO:0031468)3.09497895
83mitotic nuclear envelope reassembly (GO:0007084)3.09497895
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09167040
85regulation of ubiquitin-protein transferase activity (GO:0051438)3.07130591
86mannosylation (GO:0097502)3.06599534
87DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.04040935
88purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03011469
89maturation of 5.8S rRNA (GO:0000460)3.01726839
90rRNA methylation (GO:0031167)3.01118677
91DNA strand elongation involved in DNA replication (GO:0006271)3.00083300
92translation (GO:0006412)3.00076992
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.00067685
94mitochondrion morphogenesis (GO:0070584)3.00013841
95oxidative phosphorylation (GO:0006119)2.99287297
96tRNA processing (GO:0008033)2.99229995
97intracellular protein transmembrane import (GO:0044743)2.98487091
98response to muramyl dipeptide (GO:0032495)2.98482301
99rRNA processing (GO:0006364)2.98456269
100tRNA metabolic process (GO:0006399)2.97678734
101ATP hydrolysis coupled proton transport (GO:0015991)2.96829877
102energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.96829877
103cellular response to nicotine (GO:0071316)2.95501917
104phagosome maturation (GO:0090382)2.94952842
105translational initiation (GO:0006413)2.93993250
106deoxyribose phosphate catabolic process (GO:0046386)2.93660363
107proton transport (GO:0015992)2.93446417
108regulation of ligase activity (GO:0051340)2.93302334
109protein complex disassembly (GO:0043241)2.93027277
110ribonucleoside triphosphate biosynthetic process (GO:0009201)2.92340482
111deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.91831497
112ribosomal large subunit biogenesis (GO:0042273)2.88191821
113GTP biosynthetic process (GO:0006183)2.87546583
114hydrogen transport (GO:0006818)2.86917812
115negative regulation of multicellular organism growth (GO:0040015)2.86295237
116platelet dense granule organization (GO:0060155)2.83651014
117macromolecular complex disassembly (GO:0032984)2.83259110
118histone H2A acetylation (GO:0043968)2.81333397
119viral protein processing (GO:0019082)2.78881684
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73537549
1217-methylguanosine mRNA capping (GO:0006370)2.71153524
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71050335
123regulation of cellular amino acid metabolic process (GO:0006521)2.70647692
124DNA integration (GO:0015074)2.69784570
125CTP metabolic process (GO:0046036)2.69116631
126CTP biosynthetic process (GO:0006241)2.69116631
127melanosome localization (GO:0032400)2.68843679
128macrophage chemotaxis (GO:0048246)2.67794983
129anterograde synaptic vesicle transport (GO:0048490)2.67183157
130cellular response to interferon-beta (GO:0035458)2.66346125
131inner mitochondrial membrane organization (GO:0007007)2.66044991
132protein deneddylation (GO:0000338)2.63728420
133DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61882441
134aerobic respiration (GO:0009060)2.61752914
135positive regulation of monocyte chemotaxis (GO:0090026)2.60229637
136cullin deneddylation (GO:0010388)2.56659494
137RNA capping (GO:0036260)2.55305243
1387-methylguanosine RNA capping (GO:0009452)2.55305243
139response to interferon-beta (GO:0035456)2.55227664
140protein-cofactor linkage (GO:0018065)2.55066365
141negative regulation of interleukin-17 production (GO:0032700)2.53146075
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.52755637
143termination of RNA polymerase III transcription (GO:0006386)2.52755637
144pigment granule localization (GO:0051875)2.51863096
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.51121773
146intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.51121773
147cytochrome complex assembly (GO:0017004)2.50463257
148respiratory chain complex IV assembly (GO:0008535)2.50313058
149DNA deamination (GO:0045006)2.50272531
150nucleoside triphosphate biosynthetic process (GO:0009142)2.50230943
151purinergic nucleotide receptor signaling pathway (GO:0035590)2.49505096
152negative regulation of microtubule polymerization (GO:0031115)2.49407408
153pyrimidine nucleotide catabolic process (GO:0006244)2.48874163
154signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.48334940
155signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.48334940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.40636465
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81182870
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.44577179
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.39694945
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.38507581
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10511345
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93474469
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74209430
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71842903
10CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.71604012
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66941742
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.62750840
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.58320328
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56712372
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55322050
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51755746
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51517815
18E2F7_22180533_ChIP-Seq_HELA_Human2.50550758
19FOXP3_21729870_ChIP-Seq_TREG_Human2.42611158
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39606306
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.27791999
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17024206
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.14442056
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.07980911
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06594848
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06005188
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05008355
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04759301
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01736261
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99733156
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97245080
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92116844
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90676608
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90091086
35ELK1_22589737_ChIP-Seq_MCF10A_Human1.85550352
36* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85145970
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79027909
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76905925
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76422857
40XRN2_22483619_ChIP-Seq_HELA_Human1.70861092
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68815465
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64703301
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64381181
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.64295415
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63553286
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63101088
47CTCF_18555785_ChIP-Seq_MESCs_Mouse1.61219315
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60019797
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59828862
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58833173
51DCP1A_22483619_ChIP-Seq_HELA_Human1.58064959
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55867788
53* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54876760
54CIITA_25753668_ChIP-Seq_RAJI_Human1.53327801
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52605288
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52593122
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52201868
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51208175
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50215791
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48853590
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48696521
62KDM5A_27292631_Chip-Seq_BREAST_Human1.44606637
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41799547
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40741875
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40627440
66* MYC_18940864_ChIP-ChIP_HL60_Human1.39392852
67VDR_23849224_ChIP-Seq_CD4+_Human1.39043187
68* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39004467
69SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.38081463
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36289862
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35024864
72* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34081179
73STAT1_20625510_ChIP-Seq_HELA_Human1.32264932
74TTF2_22483619_ChIP-Seq_HELA_Human1.32068425
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29341467
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29110802
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.26575222
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25758145
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25297889
80* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24797666
81IRF1_19129219_ChIP-ChIP_H3396_Human1.24574850
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21624759
83* SPI1_23547873_ChIP-Seq_NB4_Human1.21169133
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19989693
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.18010879
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17083608
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17015092
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16681658
89BCL6_27268052_Chip-Seq_Bcells_Human1.15910915
90* FOXP1_21924763_ChIP-Seq_HESCs_Human1.15453652
91ELK1_19687146_ChIP-ChIP_HELA_Human1.15380112
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14980307
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.14542544
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13052042
95SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12249627
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11093768
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10401641
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07857243
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06919087
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06095003
101IRF8_22096565_ChIP-ChIP_GC-B_Human1.05866316
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05788178
103FOXM1_23109430_ChIP-Seq_U2OS_Human1.05149312
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04879354
105LXR_22292898_ChIP-Seq_THP-1_Human1.04676274
106* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03236896
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03156910
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02485018
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.02285302
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.01730915
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99471976
112RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98858239
113SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98142183
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97926702
115* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97412847
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96669880
117* GABP_19822575_ChIP-Seq_HepG2_Human0.96190888
118BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95647513
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95345783
120JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95132603
121* TET1_21451524_ChIP-Seq_MESCs_Mouse0.94533577
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93249757
123ZNF263_19887448_ChIP-Seq_K562_Human0.92337789
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92263189
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92040245
126TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91771270
127SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90651217
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89969856
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89772783
130SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89718344
131SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89063214
132* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88831483
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88547507
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88324218
135TFEB_21752829_ChIP-Seq_HELA_Human0.83902129
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83457441
137* ELF5_23300383_ChIP-Seq_T47D_Human0.82986364
138CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82692117
139* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81131162
140KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80415435
141ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77791473
142SOX17_20123909_ChIP-Seq_XEN_Mouse0.75328304
143HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75307799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.81678501
2MP0008058_abnormal_DNA_repair3.69790835
3MP0001764_abnormal_homeostasis3.65737291
4MP0003806_abnormal_nucleotide_metabolis3.38136700
5MP0003693_abnormal_embryo_hatching3.36950862
6MP0001542_abnormal_bone_strength3.14148211
7MP0010386_abnormal_urinary_bladder2.99009684
8MP0001529_abnormal_vocalization2.98012773
9MP0002234_abnormal_pharynx_morphology2.84308306
10MP0002638_abnormal_pupillary_reflex2.73158621
11MP0008877_abnormal_DNA_methylation2.56911633
12MP0004957_abnormal_blastocyst_morpholog2.55411640
13MP0005058_abnormal_lysosome_morphology2.54550366
14MP0010094_abnormal_chromosome_stability2.53603710
15MP0001905_abnormal_dopamine_level2.50252233
16MP0001346_abnormal_lacrimal_gland2.44229670
17MP0001835_abnormal_antigen_presentation2.43334872
18MP0008007_abnormal_cellular_replicative2.42731879
19MP0009785_altered_susceptibility_to2.39421791
20MP0003786_premature_aging2.32986935
21MP0003315_abnormal_perineum_morphology2.18169332
22MP0002148_abnormal_hypersensitivity_rea2.15489001
23MP0005671_abnormal_response_to2.12930037
24MP0005084_abnormal_gallbladder_morpholo2.12556395
25MP0003111_abnormal_nucleus_morphology2.11234713
26MP0001188_hyperpigmentation2.07083166
27MP0002736_abnormal_nociception_after2.03695193
28MP0008932_abnormal_embryonic_tissue2.01051892
29MP0004142_abnormal_muscle_tone2.00310630
30MP0003303_peritoneal_inflammation1.99236098
31MP0003718_maternal_effect1.98814927
32MP0002160_abnormal_reproductive_system1.96670079
33MP0000685_abnormal_immune_system1.95073475
34MP0003436_decreased_susceptibility_to1.91838334
35MP0002277_abnormal_respiratory_mucosa1.91052873
36MP0006276_abnormal_autonomic_nervous1.90374994
37MP0008789_abnormal_olfactory_epithelium1.83951189
38MP0003880_abnormal_central_pattern1.81946077
39MP0002132_abnormal_respiratory_system1.81128241
40MP0002089_abnormal_postnatal_growth/wei1.76032373
41MP0002419_abnormal_innate_immunity1.74675393
42MP0001968_abnormal_touch/_nociception1.73518290
43MP0005025_abnormal_response_to1.72647954
44MP0000538_abnormal_urinary_bladder1.70310125
45MP0003122_maternal_imprinting1.69472101
46MP0003077_abnormal_cell_cycle1.68435475
47MP0003866_abnormal_defecation1.67665931
48MP0005075_abnormal_melanosome_morpholog1.67331120
49MP0006072_abnormal_retinal_apoptosis1.66924998
50MP0005389_reproductive_system_phenotype1.66270277
51MP0001853_heart_inflammation1.66076230
52MP0008004_abnormal_stomach_pH1.65909354
53MP0003186_abnormal_redox_activity1.60551563
54MP0003191_abnormal_cellular_cholesterol1.59436196
55MP0002102_abnormal_ear_morphology1.58644159
56MP0002396_abnormal_hematopoietic_system1.52734277
57MP0000358_abnormal_cell_content/1.51704095
58MP0006082_CNS_inflammation1.50340754
59MP0004883_abnormal_blood_vessel1.46656671
60MP0005000_abnormal_immune_tolerance1.46135481
61MP0001663_abnormal_digestive_system1.39377692
62MP0006035_abnormal_mitochondrial_morpho1.38874558
63MP0000516_abnormal_urinary_system1.38737883
64MP0005367_renal/urinary_system_phenotyp1.38737883
65MP0000015_abnormal_ear_pigmentation1.38671124
66MP0000343_altered_response_to1.38587419
67MP0002723_abnormal_immune_serum1.36773696
68MP0005174_abnormal_tail_pigmentation1.36357643
69MP0006292_abnormal_olfactory_placode1.32944275
70MP0004043_abnormal_pH_regulation1.32190777
71MP0003724_increased_susceptibility_to1.31506260
72MP0002837_dystrophic_cardiac_calcinosis1.29954645
73MP0003011_delayed_dark_adaptation1.28102173
74MP0005164_abnormal_response_to1.27398415
75MP0005645_abnormal_hypothalamus_physiol1.26262701
76MP0002452_abnormal_antigen_presenting1.25903152
77MP0001533_abnormal_skeleton_physiology1.24304807
78MP0006036_abnormal_mitochondrial_physio1.23865340
79MP0002090_abnormal_vision1.23703654
80MP0002420_abnormal_adaptive_immunity1.23516138
81MP0004019_abnormal_vitamin_homeostasis1.22709622
82MP0008469_abnormal_protein_level1.22491681
83MP0001790_abnormal_immune_system1.22327370
84MP0005387_immune_system_phenotype1.22327370
85MP0002557_abnormal_social/conspecific_i1.22277097
86MP0001819_abnormal_immune_cell1.21753743
87MP0005464_abnormal_platelet_physiology1.20312369
88MP0001727_abnormal_embryo_implantation1.19922316
89MP0010030_abnormal_orbit_morphology1.16677620
90MP0001970_abnormal_pain_threshold1.16459194
91MP0001873_stomach_inflammation1.14409349
92MP0005248_abnormal_Harderian_gland1.13835705
93MP0000858_altered_metastatic_potential1.13815319
94MP0005408_hypopigmentation1.12540239
95MP0000372_irregular_coat_pigmentation1.12472414
96MP0002733_abnormal_thermal_nociception1.11905995
97MP0003123_paternal_imprinting1.11497118
98MP0004147_increased_porphyrin_level1.10234230
99MP0008872_abnormal_physiological_respon1.06747263
100MP0003279_aneurysm1.06635782
101MP0001984_abnormal_olfaction1.05959824
102MP0003172_abnormal_lysosome_physiology1.05361525
103MP0000371_diluted_coat_color1.03952332
104MP0005376_homeostasis/metabolism_phenot1.03818108
105MP0002163_abnormal_gland_morphology1.03460059
106MP0005171_absent_coat_pigmentation1.02874531
107MP0008873_increased_physiological_sensi1.02240354
108MP0009046_muscle_twitch1.01614628
109MP0005499_abnormal_olfactory_system1.01144167
110MP0005394_taste/olfaction_phenotype1.01144167
111MP0005266_abnormal_metabolism1.00420328
112MP0000604_amyloidosis1.00403530
113MP0001986_abnormal_taste_sensitivity1.00017256
114MP0001800_abnormal_humoral_immune0.99667687
115MP0002735_abnormal_chemical_nociception0.99482350
116MP0000026_abnormal_inner_ear0.99053026
117MP0001919_abnormal_reproductive_system0.96324169
118MP0002909_abnormal_adrenal_gland0.94756529
119MP0002938_white_spotting0.94320462
120MP0005381_digestive/alimentary_phenotyp0.92441509
121MP0001293_anophthalmia0.92431803
122MP0002064_seizures0.91681104
123MP0009053_abnormal_anal_canal0.90773160
124MP0004134_abnormal_chest_morphology0.89759141
125MP0002184_abnormal_innervation0.88949187
126MP0001845_abnormal_inflammatory_respons0.88000729
127MP0000716_abnormal_immune_system0.87835162
128MP0009840_abnormal_foam_cell0.87317515
129MP0002177_abnormal_outer_ear0.86861679
130MP0009697_abnormal_copulation0.86837496
131MP0002572_abnormal_emotion/affect_behav0.84972819
132MP0000465_gastrointestinal_hemorrhage0.84636728
133MP0001879_abnormal_lymphatic_vessel0.84515591
134MP0001440_abnormal_grooming_behavior0.84027020
135MP0001270_distended_abdomen0.83184897
136MP0005083_abnormal_biliary_tract0.82076209
137MP0003329_amyloid_beta_deposits0.81683364
138MP0000778_abnormal_nervous_system0.81181338
139MP0000751_myopathy0.80424647
140MP0008875_abnormal_xenobiotic_pharmacok0.80024851
141MP0001664_abnormal_digestion0.80011957
142MP0005636_abnormal_mineral_homeostasis0.79861189
143MP0000490_abnormal_crypts_of0.78729466
144MP0000749_muscle_degeneration0.78552981
145MP0002751_abnormal_autonomic_nervous0.77943900
146MP0002876_abnormal_thyroid_physiology0.77834007
147MP0009333_abnormal_splenocyte_physiolog0.77299363
148MP0003634_abnormal_glial_cell0.77132953
149MP0005332_abnormal_amino_acid0.76797592
150MP0000313_abnormal_cell_death0.75931700
151MP0000920_abnormal_myelination0.75914931
152MP0001145_abnormal_male_reproductive0.75857755
153MP0000689_abnormal_spleen_morphology0.75718186
154MP0002272_abnormal_nervous_system0.75094708
155MP0000049_abnormal_middle_ear0.75071642
156MP0002210_abnormal_sex_determination0.74464873
157MP0000350_abnormal_cell_proliferation0.74183772
158MP0005646_abnormal_pituitary_gland0.73041454
159MP0004133_heterotaxia0.72405742
160MP0002095_abnormal_skin_pigmentation0.71400345
161MP0002019_abnormal_tumor_incidence0.70696288
162MP0003567_abnormal_fetal_cardiomyocyte0.69119403
163MP0005165_increased_susceptibility_to0.68639907
164MP0005379_endocrine/exocrine_gland_phen0.68037554
165MP0005501_abnormal_skin_physiology0.66010233
166MP0000653_abnormal_sex_gland0.65912800
167MP0001929_abnormal_gametogenesis0.62929234
168MP0003121_genomic_imprinting0.59056049
169MP0005410_abnormal_fertilization0.58471935
170MP0009745_abnormal_behavioral_response0.57994192
171MP0001186_pigmentation_phenotype0.57883391
172MP0000750_abnormal_muscle_regeneration0.56155376

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)5.76728558
2Acute necrotizing encephalopathy (HP:0006965)5.67776797
3Abnormal mitochondria in muscle tissue (HP:0008316)5.11169391
4Mitochondrial inheritance (HP:0001427)4.98650991
5Acute encephalopathy (HP:0006846)4.65545563
6Progressive macrocephaly (HP:0004481)4.43698516
7Hepatocellular necrosis (HP:0001404)4.30030631
8Renal Fanconi syndrome (HP:0001994)4.22241426
9Premature ovarian failure (HP:0008209)4.20423076
10Increased CSF lactate (HP:0002490)4.06608139
11Abnormality of cells of the erythroid lineage (HP:0012130)3.94391880
12Increased hepatocellular lipid droplets (HP:0006565)3.87274998
13Hepatic necrosis (HP:0002605)3.84987856
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.63353840
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.58103724
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.58103724
17Abnormal number of erythroid precursors (HP:0012131)3.48500925
18Aplastic anemia (HP:0001915)3.44263878
19Lipid accumulation in hepatocytes (HP:0006561)3.40729546
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.35148996
21Exertional dyspnea (HP:0002875)3.28027176
22Abnormal protein glycosylation (HP:0012346)3.27255976
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.27255976
24Abnormal protein N-linked glycosylation (HP:0012347)3.27255976
25Abnormality of glycolysis (HP:0004366)3.27175791
26Increased serum pyruvate (HP:0003542)3.27175791
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.24463071
28Vascular calcification (HP:0004934)3.17444203
29Increased intramyocellular lipid droplets (HP:0012240)3.08024747
303-Methylglutaconic aciduria (HP:0003535)2.99724327
31Vacuolated lymphocytes (HP:0001922)2.98179994
32Neuroendocrine neoplasm (HP:0100634)2.95383058
33Abnormality of renal resorption (HP:0011038)2.93845610
34Respiratory failure (HP:0002878)2.93144573
35Hypergonadotropic hypogonadism (HP:0000815)2.88130169
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.87850976
37Reticulocytopenia (HP:0001896)2.86795296
38Lactic acidosis (HP:0003128)2.84581500
39Optic disc pallor (HP:0000543)2.83296055
40Abnormal gallbladder physiology (HP:0012438)2.81588423
41Cholecystitis (HP:0001082)2.81588423
42Cardiovascular calcification (HP:0011915)2.79484677
43Sensory axonal neuropathy (HP:0003390)2.75357399
44Reduced antithrombin III activity (HP:0001976)2.75160187
45Cerebral edema (HP:0002181)2.71911765
46Exercise intolerance (HP:0003546)2.70953346
47Cerebral palsy (HP:0100021)2.70789382
48Increased serum lactate (HP:0002151)2.67622016
49Increased muscle lipid content (HP:0009058)2.66999159
50Generalized hypopigmentation (HP:0007513)2.62205039
51Hypothermia (HP:0002045)2.60812641
52Lethargy (HP:0001254)2.55827012
53Osteomalacia (HP:0002749)2.53568064
54Leukodystrophy (HP:0002415)2.52464152
55Parakeratosis (HP:0001036)2.52134935
56Testicular atrophy (HP:0000029)2.49994550
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46535948
58Opisthotonus (HP:0002179)2.36268457
59Delayed CNS myelination (HP:0002188)2.34877852
60Abnormal urine phosphate concentration (HP:0012599)2.34794256
61Type I transferrin isoform profile (HP:0003642)2.34261150
62Abnormality of the vocal cords (HP:0008777)2.32882184
63Increased cerebral lipofuscin (HP:0011813)2.32509152
64Hypoplastic pelvis (HP:0008839)2.29901737
65Dry hair (HP:0011359)2.29333277
66Methylmalonic aciduria (HP:0012120)2.27675708
67Hypoplasia of the uterus (HP:0000013)2.25261802
68Microvesicular hepatic steatosis (HP:0001414)2.24583660
69Panhypogammaglobulinemia (HP:0003139)2.22891744
70Axonal loss (HP:0003447)2.21875276
71Agammaglobulinemia (HP:0004432)2.21833568
72Respiratory difficulties (HP:0002880)2.21073033
73Elevated erythrocyte sedimentation rate (HP:0003565)2.19501128
74Recurrent abscess formation (HP:0002722)2.19304683
75Pheochromocytoma (HP:0002666)2.18292518
76Emotional lability (HP:0000712)2.17846618
77Thyroid-stimulating hormone excess (HP:0002925)2.17773568
78Hyperphosphatemia (HP:0002905)2.17615971
79Basal ganglia calcification (HP:0002135)2.16931647
80Pancytopenia (HP:0001876)2.14224539
81Rough bone trabeculation (HP:0100670)2.11859302
82Delusions (HP:0000746)2.10593401
83Sex reversal (HP:0012245)2.07141324
84Abnormal sex determination (HP:0012244)2.07141324
85Conjunctival hamartoma (HP:0100780)2.04084024
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02822200
87Dicarboxylic aciduria (HP:0003215)2.02822200
88CNS hypomyelination (HP:0003429)2.02665854
89Pallor (HP:0000980)2.01887810
90Heterochromia iridis (HP:0001100)2.01628288
91Macrocytic anemia (HP:0001972)2.00441942
92Aplasia/hypoplasia of the uterus (HP:0008684)2.00086968
93Methylmalonic acidemia (HP:0002912)1.99881862
94Hyperphosphaturia (HP:0003109)1.98956293
95Oral leukoplakia (HP:0002745)1.96941840
96CNS demyelination (HP:0007305)1.96788531
97Mediastinal lymphadenopathy (HP:0100721)1.93713090
98Microretrognathia (HP:0000308)1.93354357
99Progressive neurologic deterioration (HP:0002344)1.91897149
100Neoplasm of the adrenal gland (HP:0100631)1.91757551
101Hypoplastic left heart (HP:0004383)1.90171092
102Abnormality of the anterior horn cell (HP:0006802)1.89560416
103Degeneration of anterior horn cells (HP:0002398)1.89560416
104Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84319747
105Metabolic acidosis (HP:0001942)1.83244649
106Large eyes (HP:0001090)1.81933505
107Recurrent bacterial skin infections (HP:0005406)1.80505785
108Abnormality of placental membranes (HP:0011409)1.79374334
109Amniotic constriction ring (HP:0009775)1.79374334
110Retinal dysplasia (HP:0007973)1.77735893
111Abnormality of the labia minora (HP:0012880)1.77515201
112Muscle fiber atrophy (HP:0100295)1.76770581
113Limb dystonia (HP:0002451)1.76649386
114Neoplasm of head and neck (HP:0012288)1.76525442
115Esophageal neoplasm (HP:0100751)1.76525442
116Orthostatic hypotension (HP:0001278)1.75462975
117Systemic lupus erythematosus (HP:0002725)1.74759983
118Progressive microcephaly (HP:0000253)1.74164110
119Vomiting (HP:0002013)1.73452904
120Abnormality of urine glucose concentration (HP:0011016)1.73260245
121Glycosuria (HP:0003076)1.73260245
122Anomalous pulmonary venous return (HP:0010772)1.73255172
123Type 2 muscle fiber atrophy (HP:0003554)1.72977194
124Abnormality of the basal ganglia (HP:0002134)1.72326057
125Sclerocornea (HP:0000647)1.72246149
126Cerebral hypomyelination (HP:0006808)1.72139589
127Hypoplasia of the pons (HP:0012110)1.71719569
128Split foot (HP:0001839)1.71481180
129Colon cancer (HP:0003003)1.71264752
130Abnormality of hair growth rate (HP:0011363)1.71023700
131Slow-growing hair (HP:0002217)1.71023700
132Poor suck (HP:0002033)1.70585238
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70369734
134Abnormality of alanine metabolism (HP:0010916)1.70369734
135Hyperalaninemia (HP:0003348)1.70369734
136Hypertensive crisis (HP:0100735)1.69523649
137Retinal atrophy (HP:0001105)1.67339726
138Dysostosis multiplex (HP:0000943)1.67263895
139Iris hypopigmentation (HP:0007730)1.66923616
140X-linked dominant inheritance (HP:0001423)1.66405255
141Redundant skin (HP:0001582)1.66240308
142Decreased lacrimation (HP:0000633)1.66035267
143Multiple enchondromatosis (HP:0005701)1.65130274
144Chronic mucocutaneous candidiasis (HP:0002728)1.65020034
145Recurrent cutaneous fungal infections (HP:0011370)1.65020034
146Gliosis (HP:0002171)1.64758440
147Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.64088460
148Blindness (HP:0000618)1.63866894
149Abnormal glycosylation (HP:0012345)1.63730195
150Sparse eyelashes (HP:0000653)1.63184725
151Generalized aminoaciduria (HP:0002909)1.62207959
152Congenital, generalized hypertrichosis (HP:0004540)1.61595250
153Abnormality of the pons (HP:0007361)1.57295757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.06640685
2MAP3K124.07486519
3SIK33.03290974
4TNIK2.83548271
5TNK22.81452196
6TAOK22.52686195
7BLK2.42296582
8ARAF2.39373224
9LIMK12.37527262
10NME22.36531371
11TESK12.29783790
12MST42.27147450
13NUAK12.24465428
14CDC72.15659321
15MYLK2.12423192
16TLK12.12131049
17MAP4K22.10388112
18RIPK41.96306358
19TBK11.93013667
20TAF11.87175628
21ZAK1.85837993
22PIM21.76482968
23MAP2K71.66630268
24EIF2AK31.65627208
25TRIB31.64492139
26BMX1.61875347
27FES1.59135185
28DAPK11.57261586
29GRK71.55826505
30ZAP701.55694149
31SRPK11.51665862
32MAP2K31.48089328
33CASK1.46961162
34PLK31.46829158
35PRPF4B1.45893443
36CSNK1G31.41177381
37MAP3K111.39699628
38SCYL21.38528844
39MAP2K61.36053597
40PKN21.35341393
41MINK11.31149268
42ADRBK21.30525952
43DYRK21.26723506
44CSNK1G21.25897532
45MAPK131.24064200
46BCR1.24003787
47ERN11.23605302
48TRIM281.23388651
49NEK11.22672815
50LMTK21.22025618
51VRK11.21614000
52BRAF1.18850542
53IRAK11.16535021
54MAP3K51.16356457
55YES11.15036640
56EIF2AK11.10890414
57PLK41.10302421
58EPHB21.09929470
59LRRK21.08743093
60PASK1.07651553
61IKBKB1.05684005
62CSNK1A1L1.05201263
63PRKCI1.04434971
64PBK1.03207242
65CSNK1G11.01227932
66STK161.00179867
67CDK80.97973033
68MAPKAPK30.97502590
69PLK10.95955594
70PHKG10.95280292
71PHKG20.95280292
72KIT0.94690140
73TESK20.93960544
74IRAK20.93371685
75MAPKAPK50.92697484
76BCKDK0.92150078
77SYK0.91513307
78AURKA0.90456994
79MAPK120.89307881
80ILK0.86814343
81ABL20.85651529
82MAP2K40.85331299
83BMPR1B0.84038394
84AURKB0.82087437
85PLK20.81512549
86IKBKE0.79257615
87BUB10.78842920
88TTK0.78364451
89IRAK40.77999280
90IRAK30.77693499
91MAP3K140.77363918
92PAK40.75190173
93GRK60.74953651
94BMPR20.74398249
95ATR0.70281212
96ADRBK10.70274474
97GRK50.70081089
98WNK30.69381142
99EIF2AK20.68232190
100PTK2B0.67098515
101TSSK60.67050472
102CHEK20.66577598
103LYN0.64770043
104CDK70.63854395
105KDR0.62129350
106CSNK2A10.61918417
107NME10.61866358
108MAP2K20.60241549
109CSNK2A20.60153067
110DAPK30.59749139
111JAK30.59714058
112MAP2K10.57047011
113EPHA20.55718075
114CDK190.54423502
115BRSK10.52710873
116PDK20.52654943
117GRK10.50925175
118PAK10.50504188
119MAP4K10.49465901
120PRKG20.49178283
121MAPK40.48634607
122PTK60.48355793
123RPS6KA50.47769516
124RPS6KB20.47050385
125TIE10.46811991
126CDK30.46597292
127MUSK0.45936496
128CSF1R0.45756590
129MAPKAPK20.44249939
130TYK20.41294847
131CDK140.40927082
132BTK0.40563177
133CDK11A0.40069661
134MARK10.38392286
135SMG10.38171539
136PINK10.38151895
137MAP3K10.37527805
138NTRK30.37462626
139ROCK10.37320500
140UHMK10.37027284
141AKT20.36575246
142PRKCE0.35919865
143CAMK2G0.35492068
144NLK0.35259399
145CCNB10.32517433
146CDK180.32379614
147CSNK1A10.31629507
148NTRK20.31447329
149CDK150.31439664
150PRKCD0.31361204
151FRK0.31053541
152PRKD30.30738729
153PRKCG0.30333438
154ALK0.30026495
155NEK20.29828407
156CHEK10.28332198
157PRKD20.27593045
158OXSR10.27455881
159RPS6KA40.26660386
160ATM0.24667381

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.69261189
2Parkinsons disease_Homo sapiens_hsa050124.69431919
3Ribosome_Homo sapiens_hsa030104.45430284
4Proteasome_Homo sapiens_hsa030503.72437637
5Alzheimers disease_Homo sapiens_hsa050103.65097349
6Huntingtons disease_Homo sapiens_hsa050163.06346095
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.04917579
8Homologous recombination_Homo sapiens_hsa034402.98236320
9Mismatch repair_Homo sapiens_hsa034302.81556867
10RNA polymerase_Homo sapiens_hsa030202.48148008
11Collecting duct acid secretion_Homo sapiens_hsa049662.46142062
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26813885
13Nucleotide excision repair_Homo sapiens_hsa034202.00022876
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97370638
15Vibrio cholerae infection_Homo sapiens_hsa051101.74380987
16Protein export_Homo sapiens_hsa030601.68300380
17Fanconi anemia pathway_Homo sapiens_hsa034601.64396416
18Non-homologous end-joining_Homo sapiens_hsa034501.61821265
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59813266
20Regulation of autophagy_Homo sapiens_hsa041401.59806869
21Cardiac muscle contraction_Homo sapiens_hsa042601.58516882
22Rheumatoid arthritis_Homo sapiens_hsa053231.56651713
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40126745
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37669001
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33020605
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31761427
27Phenylalanine metabolism_Homo sapiens_hsa003601.27025794
28One carbon pool by folate_Homo sapiens_hsa006701.26920174
29Pyrimidine metabolism_Homo sapiens_hsa002401.25934659
30Phagosome_Homo sapiens_hsa041451.24740695
31Basal transcription factors_Homo sapiens_hsa030221.21170141
32RNA transport_Homo sapiens_hsa030131.19666602
33Other glycan degradation_Homo sapiens_hsa005111.15969364
34Pyruvate metabolism_Homo sapiens_hsa006201.15348051
35Leishmaniasis_Homo sapiens_hsa051401.11094357
36RNA degradation_Homo sapiens_hsa030181.07307600
37Arachidonic acid metabolism_Homo sapiens_hsa005901.06841346
38Sulfur relay system_Homo sapiens_hsa041221.06501589
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04047158
40Pertussis_Homo sapiens_hsa051331.04015260
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98590187
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96754319
43Lysosome_Homo sapiens_hsa041420.95408270
44Synaptic vesicle cycle_Homo sapiens_hsa047210.95199689
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.93945914
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93228633
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.93090213
48Carbon metabolism_Homo sapiens_hsa012000.90954129
49Biosynthesis of amino acids_Homo sapiens_hsa012300.89974246
50Peroxisome_Homo sapiens_hsa041460.89025873
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88020585
52Shigellosis_Homo sapiens_hsa051310.86579943
53Fatty acid elongation_Homo sapiens_hsa000620.84788639
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83152295
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81499418
56Epstein-Barr virus infection_Homo sapiens_hsa051690.80231290
57Spliceosome_Homo sapiens_hsa030400.75829775
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74605276
59Folate biosynthesis_Homo sapiens_hsa007900.72900957
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72384152
61Apoptosis_Homo sapiens_hsa042100.71052013
62Sulfur metabolism_Homo sapiens_hsa009200.70984354
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.70567010
64Glutathione metabolism_Homo sapiens_hsa004800.70182553
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69839673
66Histidine metabolism_Homo sapiens_hsa003400.67919947
67Steroid biosynthesis_Homo sapiens_hsa001000.67630952
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66994004
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64820955
70Hepatitis C_Homo sapiens_hsa051600.64702821
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64264067
72Tuberculosis_Homo sapiens_hsa051520.63777662
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63605484
74Caffeine metabolism_Homo sapiens_hsa002320.63222080
75Metabolic pathways_Homo sapiens_hsa011000.62841446
76Galactose metabolism_Homo sapiens_hsa000520.61237644
77Primary immunodeficiency_Homo sapiens_hsa053400.61149656
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60795703
79Allograft rejection_Homo sapiens_hsa053300.60235663
80Osteoclast differentiation_Homo sapiens_hsa043800.59934470
81Ether lipid metabolism_Homo sapiens_hsa005650.59836597
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59800883
83Phototransduction_Homo sapiens_hsa047440.58251457
84Cell cycle_Homo sapiens_hsa041100.57019875
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.55925922
86TNF signaling pathway_Homo sapiens_hsa046680.55343802
87Serotonergic synapse_Homo sapiens_hsa047260.55084195
88Legionellosis_Homo sapiens_hsa051340.54790436
89Tyrosine metabolism_Homo sapiens_hsa003500.54623575
90Prion diseases_Homo sapiens_hsa050200.54343681
91Pentose phosphate pathway_Homo sapiens_hsa000300.53682459
92B cell receptor signaling pathway_Homo sapiens_hsa046620.53457459
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52727839
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51731998
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50350364
96Vitamin digestion and absorption_Homo sapiens_hsa049770.50311902
97Selenocompound metabolism_Homo sapiens_hsa004500.49499295
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47635570
99Influenza A_Homo sapiens_hsa051640.46890882
100African trypanosomiasis_Homo sapiens_hsa051430.46265623
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46175925
102Tryptophan metabolism_Homo sapiens_hsa003800.45399230
103Fatty acid degradation_Homo sapiens_hsa000710.44664474
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44438747
105Oocyte meiosis_Homo sapiens_hsa041140.44334581
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44287175
107Acute myeloid leukemia_Homo sapiens_hsa052210.44049156
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.42918189
109Salmonella infection_Homo sapiens_hsa051320.41820538
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40997913
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40628025
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40009252
113Asthma_Homo sapiens_hsa053100.39660100
114Arginine and proline metabolism_Homo sapiens_hsa003300.39431874
115beta-Alanine metabolism_Homo sapiens_hsa004100.37915125
116Axon guidance_Homo sapiens_hsa043600.37908171
117N-Glycan biosynthesis_Homo sapiens_hsa005100.37765200
118p53 signaling pathway_Homo sapiens_hsa041150.37234337
119Butanoate metabolism_Homo sapiens_hsa006500.36984505
120Type I diabetes mellitus_Homo sapiens_hsa049400.36343739
121Nicotine addiction_Homo sapiens_hsa050330.36272254
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.35717097
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35363847
124Fatty acid metabolism_Homo sapiens_hsa012120.33957356
125Vitamin B6 metabolism_Homo sapiens_hsa007500.32353473
126Malaria_Homo sapiens_hsa051440.31928460
127Measles_Homo sapiens_hsa051620.31881576
128Purine metabolism_Homo sapiens_hsa002300.31821049
129DNA replication_Homo sapiens_hsa030300.31655229
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30293688
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30230513
132Chemical carcinogenesis_Homo sapiens_hsa052040.30061935
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28025142
134Fructose and mannose metabolism_Homo sapiens_hsa000510.27958766
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27917532
136Propanoate metabolism_Homo sapiens_hsa006400.26433526
137T cell receptor signaling pathway_Homo sapiens_hsa046600.25870522
138Base excision repair_Homo sapiens_hsa034100.25627032
139Toxoplasmosis_Homo sapiens_hsa051450.25218679
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25018423
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24432207
142Melanoma_Homo sapiens_hsa052180.20495972
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19947218
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.17837007
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15193406
146Systemic lupus erythematosus_Homo sapiens_hsa053220.15043128
147Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14778956
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.11299110

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