FICD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.88466308
2proline metabolic process (GO:0006560)7.49630113
3transcription from mitochondrial promoter (GO:0006390)7.27825879
4replication fork processing (GO:0031297)6.48605923
5embryonic process involved in female pregnancy (GO:0060136)6.19517279
6folic acid-containing compound biosynthetic process (GO:0009396)6.06506948
7regulation of plasminogen activation (GO:0010755)6.01896211
8oxidative demethylation (GO:0070989)5.63385973
9protein retention in ER lumen (GO:0006621)5.51421860
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.50318397
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.47480625
12negative regulation of acute inflammatory response (GO:0002674)5.43674282
13adenosine metabolic process (GO:0046085)5.36007047
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.32620716
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.32620716
16homocysteine metabolic process (GO:0050667)5.24985451
17poly(A)+ mRNA export from nucleus (GO:0016973)5.24068788
18positive regulation of protein homooligomerization (GO:0032464)5.19046994
19pteridine-containing compound biosynthetic process (GO:0042559)5.14944052
20regulation of gonadotropin secretion (GO:0032276)4.99778895
21DNA deamination (GO:0045006)4.97276359
22regulation of integrin activation (GO:0033623)4.92155736
23establishment of apical/basal cell polarity (GO:0035089)4.80751879
24negative regulation of JAK-STAT cascade (GO:0046426)4.76922321
25mitochondrial DNA metabolic process (GO:0032042)4.72883612
26regulation of protein homooligomerization (GO:0032462)4.72571623
27GDP-mannose metabolic process (GO:0019673)4.72520318
28response to lipoprotein particle (GO:0055094)4.54317733
29cellular response to ATP (GO:0071318)4.52264515
30mitotic G1 DNA damage checkpoint (GO:0031571)4.46942006
31COPII vesicle coating (GO:0048208)4.43998568
32glandular epithelial cell development (GO:0002068)4.43964936
33cysteine metabolic process (GO:0006534)4.36725577
34purine nucleotide salvage (GO:0032261)4.33880613
35white fat cell differentiation (GO:0050872)4.31224118
36cellular zinc ion homeostasis (GO:0006882)4.20215461
37negative regulation of fatty acid biosynthetic process (GO:0045717)4.19645519
38positive regulation of glycolytic process (GO:0045821)4.17700859
39glutamine family amino acid biosynthetic process (GO:0009084)4.16526575
40establishment or maintenance of monopolar cell polarity (GO:0061339)4.10257546
41establishment of monopolar cell polarity (GO:0061162)4.10257546
42mitotic G1/S transition checkpoint (GO:0044819)4.02151780
43G1 DNA damage checkpoint (GO:0044783)4.01638898
44columnar/cuboidal epithelial cell development (GO:0002066)3.99578777
45regulation of type B pancreatic cell apoptotic process (GO:2000674)3.98731942
46embryonic placenta development (GO:0001892)3.98507894
47labyrinthine layer development (GO:0060711)3.97636676
48intestinal epithelial cell development (GO:0060576)3.93320640
49Golgi transport vesicle coating (GO:0048200)3.93059228
50COPI coating of Golgi vesicle (GO:0048205)3.93059228
51intestinal cholesterol absorption (GO:0030299)3.81296030
52rRNA methylation (GO:0031167)3.80022386
53desmosome organization (GO:0002934)3.79216647
54regulation of vitamin D biosynthetic process (GO:0060556)3.71822742
55ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.70099226
56preassembly of GPI anchor in ER membrane (GO:0016254)3.69615622
57sulfur amino acid catabolic process (GO:0000098)3.69456590
58microtubule nucleation (GO:0007020)3.69204637
59DNA strand renaturation (GO:0000733)3.68183887
60mRNA cleavage (GO:0006379)3.67343564
61vitamin transmembrane transport (GO:0035461)3.65555332
62somatic diversification of immune receptors via somatic mutation (GO:0002566)3.65270662
63somatic hypermutation of immunoglobulin genes (GO:0016446)3.65270662
64acrosome assembly (GO:0001675)3.56862251
65maturation of 5.8S rRNA (GO:0000460)3.55748057
66ER to Golgi vesicle-mediated transport (GO:0006888)3.55700456
67regulation of RNA export from nucleus (GO:0046831)3.55558905
68histone H4-K12 acetylation (GO:0043983)3.53551659
69nucleotide-sugar biosynthetic process (GO:0009226)3.52914324
70inner ear receptor cell development (GO:0060119)3.52526846
71cellular ketone body metabolic process (GO:0046950)3.48796317
72signal peptide processing (GO:0006465)3.45985568
73activation of Rac GTPase activity (GO:0032863)3.45890243
74negative regulation of DNA biosynthetic process (GO:2000279)3.45014593
75regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.44713930
76negative regulation of cell cycle arrest (GO:0071157)3.42277555
77aminoglycoside antibiotic metabolic process (GO:0030647)3.40643451
78regulation of hexokinase activity (GO:1903299)3.39982960
79regulation of glucokinase activity (GO:0033131)3.39982960
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.39023276
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.39023276
82positive regulation of mitotic sister chromatid separation (GO:1901970)3.39023276
83tetrahydrofolate metabolic process (GO:0046653)3.34854929
84positive regulation of protein autophosphorylation (GO:0031954)3.32374775
85zinc ion homeostasis (GO:0055069)3.30077769
86regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.28797735
87respiratory chain complex IV assembly (GO:0008535)3.27732887
88neuromuscular process controlling posture (GO:0050884)3.27402080
89rRNA modification (GO:0000154)3.26576601
90biotin metabolic process (GO:0006768)3.26233652
91regulation of endothelial cell differentiation (GO:0045601)3.26227394
92regulation of early endosome to late endosome transport (GO:2000641)3.25987808
93negative regulation of protein oligomerization (GO:0032460)3.25873330
94mitochondrial respiratory chain complex I assembly (GO:0032981)3.22940520
95NADH dehydrogenase complex assembly (GO:0010257)3.22940520
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22940520
97protein complex biogenesis (GO:0070271)3.21390241
98ketone body metabolic process (GO:1902224)3.20194694
99regulation of cholesterol homeostasis (GO:2000188)3.19650657
100eosinophil chemotaxis (GO:0048245)3.19606962
101protein targeting to vacuole (GO:0006623)3.18953496
102protein targeting to lysosome (GO:0006622)3.18953496
103establishment of protein localization to vacuole (GO:0072666)3.18953496
104convergent extension (GO:0060026)3.18031148
105folic acid-containing compound metabolic process (GO:0006760)3.16519648
106heme transport (GO:0015886)3.15476310
107activin receptor signaling pathway (GO:0032924)3.15416460
108C-terminal protein lipidation (GO:0006501)3.14911407
109activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.14173251
110protein maturation by protein folding (GO:0022417)3.13857851
111pteridine-containing compound metabolic process (GO:0042558)3.13388934
112viral mRNA export from host cell nucleus (GO:0046784)3.13047201
113prenylation (GO:0097354)3.12156050
114protein prenylation (GO:0018342)3.12156050
115regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.11134668
116zinc ion transmembrane transport (GO:0071577)3.08291093
117platelet dense granule organization (GO:0060155)3.06766920
118positive regulation of receptor recycling (GO:0001921)3.06400243
119adult feeding behavior (GO:0008343)3.05714839
120water-soluble vitamin biosynthetic process (GO:0042364)3.04714521
121positive regulation of circadian rhythm (GO:0042753)3.04351350
122protein-chromophore linkage (GO:0018298)3.03887270
123epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.03848867
124regulation of cAMP-dependent protein kinase activity (GO:2000479)3.02561824
125adaptation of signaling pathway (GO:0023058)3.02411058
126regulation of sister chromatid cohesion (GO:0007063)3.01361540
127positive regulation of calcium ion import (GO:0090280)3.00760009
128mitochondrial RNA metabolic process (GO:0000959)3.00643225
129positive regulation of chromosome segregation (GO:0051984)3.00322765
130positive regulation of nuclease activity (GO:0032075)2.98830830
131glycerol ether metabolic process (GO:0006662)2.98484362
132endocrine pancreas development (GO:0031018)2.98466834
133trophectodermal cell differentiation (GO:0001829)2.98054170
134galactose metabolic process (GO:0006012)2.97100263
135mitotic cell cycle arrest (GO:0071850)2.96913990
136fatty acid homeostasis (GO:0055089)2.96231762
137negative regulation of heart rate (GO:0010459)2.96036938
138lactate metabolic process (GO:0006089)2.95042069
139mannosylation (GO:0097502)2.94848058
140protein localization to endosome (GO:0036010)2.93751328
141regulation of translational fidelity (GO:0006450)2.93722980
142positive regulation of endothelial cell differentiation (GO:0045603)2.92234439
1434-hydroxyproline metabolic process (GO:0019471)2.91789898
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.90822582
145protein-cofactor linkage (GO:0018065)2.90388771
146regulation of cell size (GO:0008361)2.88966357
147zinc ion transport (GO:0006829)2.87031585
148alkaloid metabolic process (GO:0009820)2.86379382
149histamine secretion (GO:0001821)2.85961735
150resolution of meiotic recombination intermediates (GO:0000712)2.84393771
151eosinophil migration (GO:0072677)2.84161701
152mitochondrial respiratory chain complex assembly (GO:0033108)2.83318769
153organic cation transport (GO:0015695)2.81945320
154C-terminal protein amino acid modification (GO:0018410)2.81401526
155regulation of vitamin metabolic process (GO:0030656)2.81123786
156negative regulation of keratinocyte proliferation (GO:0010839)2.80884477
157positive regulation of respiratory burst (GO:0060267)2.79916854
158inositol phosphate catabolic process (GO:0071545)2.79655620
159regulation of nucleobase-containing compound transport (GO:0032239)2.79185833
160vitamin transport (GO:0051180)2.78233731
161dosage compensation (GO:0007549)2.77037830
162positive regulation of response to nutrient levels (GO:0032109)2.75487665
163positive regulation of response to extracellular stimulus (GO:0032106)2.75487665
164proteasome assembly (GO:0043248)2.75367797
165transferrin transport (GO:0033572)2.75278051
166base-excision repair (GO:0006284)2.75047893
167ether metabolic process (GO:0018904)2.73393729
168regulation of nuclease activity (GO:0032069)2.73372387
169nucleoside transmembrane transport (GO:1901642)2.73040325
170energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.72560147
171ATP hydrolysis coupled proton transport (GO:0015991)2.72560147
172trivalent inorganic cation transport (GO:0072512)2.72201093
173ferric iron transport (GO:0015682)2.72201093
174meiotic chromosome segregation (GO:0045132)2.71844582
175cellular response to zinc ion (GO:0071294)2.67828154
176negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.67121166
177negative regulation of response to food (GO:0032096)2.66565536
178negative regulation of appetite (GO:0032099)2.66565536
179phosphatidylglycerol biosynthetic process (GO:0006655)2.66484635
180glycoside metabolic process (GO:0016137)2.64794456
181negative regulation of alcohol biosynthetic process (GO:1902931)2.64767796
182regulation of double-strand break repair via homologous recombination (GO:0010569)2.64605255
183regulation of protein oligomerization (GO:0032459)2.64251063
184L-alpha-amino acid transmembrane transport (GO:1902475)2.63384564
185tRNA modification (GO:0006400)2.61172655
186cytochrome complex assembly (GO:0017004)2.60383691
187peptidyl-histidine modification (GO:0018202)2.58910574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.73940824
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.82712917
3VDR_22108803_ChIP-Seq_LS180_Human2.86813513
4ZNF274_21170338_ChIP-Seq_K562_Hela2.82903891
5NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.69732901
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.60550100
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.53946045
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.51612646
9DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.50093039
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.45967925
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.36084044
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.27422776
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.24901477
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23824609
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23824609
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23824609
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23686474
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22815290
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20238684
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18940038
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.16145628
22ZNF263_19887448_ChIP-Seq_K562_Human2.15026125
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09804964
24NANOG_21062744_ChIP-ChIP_HESCs_Human2.02491481
25KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96107479
26GBX2_23144817_ChIP-Seq_PC3_Human1.94689907
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93996105
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.92593528
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.91115618
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90932357
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.90689054
32BCAT_22108803_ChIP-Seq_LS180_Human1.90664499
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89468346
34* CDX2_22108803_ChIP-Seq_LS180_Human1.87468410
35PU.1_20513432_ChIP-Seq_Bcells_Mouse1.87236920
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84218669
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83436845
38POU5F1_16518401_ChIP-PET_MESCs_Mouse1.83163822
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.82296799
40P300_19829295_ChIP-Seq_ESCs_Human1.81446315
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.79874929
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79586659
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.78346821
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77642959
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.76823887
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76051189
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73892262
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.72848352
49* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.72665331
50* LXR_22292898_ChIP-Seq_THP-1_Human1.69560219
51* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.67300808
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66378861
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65942011
54VDR_21846776_ChIP-Seq_THP-1_Human1.65806305
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65086706
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65003026
57FUS_26573619_Chip-Seq_HEK293_Human1.62016151
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.61151057
59RARB_24833708_ChIP-Seq_LIVER_Mouse1.58759177
60TP53_22573176_ChIP-Seq_HFKS_Human1.57428083
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56508070
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55354828
63SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54991800
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54754920
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.54311810
66RACK7_27058665_Chip-Seq_MCF-7_Human1.54254053
67GABP_19822575_ChIP-Seq_HepG2_Human1.52433645
68MYC_22102868_ChIP-Seq_BL_Human1.51833636
69NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51694750
70ER_23166858_ChIP-Seq_MCF-7_Human1.51694226
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.50987742
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48090125
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.47431726
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46158553
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45899628
76RARA_24833708_ChIP-Seq_LIVER_Mouse1.43762125
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43634918
78ETS1_21867929_ChIP-Seq_TH2_Mouse1.43019808
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.42223702
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.41589121
81NANOG_19829295_ChIP-Seq_ESCs_Human1.40151651
82SOX2_19829295_ChIP-Seq_ESCs_Human1.40151651
83ELK1_19687146_ChIP-ChIP_HELA_Human1.39878606
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39877767
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38944128
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38919802
87KAP1_27257070_Chip-Seq_ESCs_Mouse1.37536651
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37394154
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.36434819
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35616054
91SPI1_26923725_Chip-Seq_HPCs_Mouse1.34390171
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34313105
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33813688
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.33626490
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.32683293
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32010123
97MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31241208
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31080150
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30272909
100KDM5A_27292631_Chip-Seq_BREAST_Human1.30096654
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30005624
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27847515
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27657599
104LXR_22158963_ChIP-Seq_LIVER_Mouse1.27462557
105POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26187634
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25909976
107E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25746835
108TET1_21490601_ChIP-Seq_MESCs_Mouse1.24176320
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23905178
110SMAD4_21799915_ChIP-Seq_A2780_Human1.23387437
111ETS1_20019798_ChIP-Seq_JURKAT_Human1.22789299
112TCF4_22108803_ChIP-Seq_LS180_Human1.22672177
113BCOR_27268052_Chip-Seq_Bcells_Human1.22542355
114* STAT3_23295773_ChIP-Seq_U87_Human1.21997085
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21149404
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20332698
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20227071
118FOXM1_23109430_ChIP-Seq_U2OS_Human1.19628333
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18590806
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18498649
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18433334
122FOXA1_25329375_ChIP-Seq_VCAP_Human1.18433334
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.18176120
124* AR_25329375_ChIP-Seq_VCAP_Human1.17844598
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17357611
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.17260365
127TFEB_21752829_ChIP-Seq_HELA_Human1.17062469
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16068912
129CBP_20019798_ChIP-Seq_JUKART_Human1.16068912
130EWS_26573619_Chip-Seq_HEK293_Human1.15775475
131* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15726361
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15045985
133MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14848019
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14560820
135ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14091519
136PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13807592
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13668443
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.12562343
139ESR2_21235772_ChIP-Seq_MCF-7_Human1.12335683
140TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.12323418
141* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12209750
142GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11900920
143EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11255783
144EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10691045
145FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10379678
146KDM2B_26808549_Chip-Seq_DND41_Human1.10303852
147CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10231419
148FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09938183
149NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09931357
150NCOR_22424771_ChIP-Seq_293T_Human1.09290560
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09278613
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09224829
153EST1_17652178_ChIP-ChIP_JURKAT_Human1.09084274
154SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08492723
155* VDR_23849224_ChIP-Seq_CD4+_Human1.08378141
156FOXH1_21741376_ChIP-Seq_EPCs_Human1.08319862
157CJUN_26792858_Chip-Seq_BT549_Human1.08007593
158CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07876181
159EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07777625
160* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07386451
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07118179
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07097443
163YY1_21170310_ChIP-Seq_MESCs_Mouse1.06653688
164CREB1_26743006_Chip-Seq_LNCaP_Human1.06642464
165* PHF8_20622854_ChIP-Seq_HELA_Human1.06072143
166CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05662590
167RUNX2_22187159_ChIP-Seq_PCA_Human1.05143360
168* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04712687
169SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04684674
170E2F1_20622854_ChIP-Seq_HELA_Human1.04641539
171TAF15_26573619_Chip-Seq_HEK293_Human1.04570906
172TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04141106
173NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03617382
174OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02266952
175SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01738564
176TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00770529
177CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99931095
178TCF4_23295773_ChIP-Seq_U87_Human0.99423613
179P53_22387025_ChIP-Seq_ESCs_Mouse0.99322329
180FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98291314
181TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97982913
182MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97849631
183CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97681386
184FOXP3_21729870_ChIP-Seq_TREG_Human0.97332827
185AR_20517297_ChIP-Seq_VCAP_Human0.97316859
186STAT3_18555785_Chip-Seq_ESCs_Mouse0.97047978
187SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96125940
188PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95842138
189MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95373937
190* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95253804
191FLI1_21867929_ChIP-Seq_TH2_Mouse0.95039375
192P300_18555785_Chip-Seq_ESCs_Mouse0.94701117
193BRD4_25478319_ChIP-Seq_HGPS_Human0.93621800
194TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93537361
195PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93452834
196ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92317103
197PRDM14_20953172_ChIP-Seq_ESCs_Human0.91745227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.64973343
2MP0005646_abnormal_pituitary_gland4.01347231
3MP0003283_abnormal_digestive_organ3.86162573
4MP0004233_abnormal_muscle_weight3.67474979
5MP0005670_abnormal_white_adipose3.65842588
6MP0009278_abnormal_bone_marrow3.49597692
7MP0005171_absent_coat_pigmentation3.39973933
8MP0005365_abnormal_bile_salt2.98899500
9MP0002877_abnormal_melanocyte_morpholog2.94501692
10MP0005367_renal/urinary_system_phenotyp2.85442991
11MP0000516_abnormal_urinary_system2.85442991
12MP0002009_preneoplasia2.69308615
13MP0005058_abnormal_lysosome_morphology2.64974201
14MP0002653_abnormal_ependyma_morphology2.49282033
15MP0006072_abnormal_retinal_apoptosis2.47972766
16MP0010234_abnormal_vibrissa_follicle2.41927979
17MP0000462_abnormal_digestive_system2.38703352
18MP0002876_abnormal_thyroid_physiology2.36689172
19MP0003787_abnormal_imprinting2.30608839
20MP0003183_abnormal_peptide_metabolism2.25437751
21MP0005360_urolithiasis2.24401211
22MP0010030_abnormal_orbit_morphology2.22446207
23MP0005220_abnormal_exocrine_pancreas2.22430344
24MP0004264_abnormal_extraembryonic_tissu2.15693089
25MP0003718_maternal_effect2.15262179
26MP0009840_abnormal_foam_cell2.12424674
27MP0009780_abnormal_chondrocyte_physiolo2.04467106
28MP0002938_white_spotting2.00940652
29MP0005085_abnormal_gallbladder_physiolo1.94497041
30MP0003119_abnormal_digestive_system1.93682580
31MP0008995_early_reproductive_senescence1.92443164
32MP0003890_abnormal_embryonic-extraembry1.90514287
33MP0000639_abnormal_adrenal_gland1.88222133
34MP0003724_increased_susceptibility_to1.87213091
35MP0002254_reproductive_system_inflammat1.87087575
36MP0003950_abnormal_plasma_membrane1.87003537
37MP0002269_muscular_atrophy1.84456670
38MP0005253_abnormal_eye_physiology1.78463172
39MP0004885_abnormal_endolymph1.78077200
40MP0002295_abnormal_pulmonary_circulatio1.74197607
41MP0005551_abnormal_eye_electrophysiolog1.72930944
42MP0002736_abnormal_nociception_after1.72756203
43MP0000013_abnormal_adipose_tissue1.71086955
44MP0002693_abnormal_pancreas_physiology1.70927134
45MP0001756_abnormal_urination1.69681557
46MP0000579_abnormal_nail_morphology1.67536216
47MP0003172_abnormal_lysosome_physiology1.67496090
48MP0001944_abnormal_pancreas_morphology1.64406261
49MP0005076_abnormal_cell_differentiation1.58706375
50MP0003693_abnormal_embryo_hatching1.58351415
51MP0001764_abnormal_homeostasis1.55834376
52MP0005397_hematopoietic_system_phenotyp1.54573060
53MP0001545_abnormal_hematopoietic_system1.54573060
54MP0003786_premature_aging1.52795607
55MP0005379_endocrine/exocrine_gland_phen1.52764003
56MP0008872_abnormal_physiological_respon1.49647681
57MP0006082_CNS_inflammation1.49048166
58MP0002086_abnormal_extraembryonic_tissu1.46587988
59MP0004957_abnormal_blastocyst_morpholog1.43914194
60MP0004147_increased_porphyrin_level1.43504897
61MP0008877_abnormal_DNA_methylation1.42173432
62MP0002909_abnormal_adrenal_gland1.40298767
63MP0001697_abnormal_embryo_size1.39940272
64MP0002084_abnormal_developmental_patter1.39426539
65MP0002735_abnormal_chemical_nociception1.38819030
66MP0003186_abnormal_redox_activity1.33982356
67MP0003656_abnormal_erythrocyte_physiolo1.29807950
68MP0003111_abnormal_nucleus_morphology1.25167742
69MP0010094_abnormal_chromosome_stability1.25114205
70MP0004043_abnormal_pH_regulation1.25046138
71MP0002078_abnormal_glucose_homeostasis1.24473582
72MP0005395_other_phenotype1.22445208
73MP0005380_embryogenesis_phenotype1.20972763
74MP0001672_abnormal_embryogenesis/_devel1.20972763
75MP0003806_abnormal_nucleotide_metabolis1.19500994
76MP0005084_abnormal_gallbladder_morpholo1.19438039
77MP0003045_fibrosis1.19139622
78MP0003453_abnormal_keratinocyte_physiol1.19025567
79MP0002085_abnormal_embryonic_tissue1.18231977
80MP0003252_abnormal_bile_duct1.15978898
81MP0000372_irregular_coat_pigmentation1.14172937
82MP0001730_embryonic_growth_arrest1.12905284
83MP0005645_abnormal_hypothalamus_physiol1.12150297
84MP0003011_delayed_dark_adaptation1.11653855
85MP0009643_abnormal_urine_homeostasis1.07488614
86MP0001919_abnormal_reproductive_system1.06912266
87MP0005389_reproductive_system_phenotype1.06172037
88MP0005636_abnormal_mineral_homeostasis1.04706381
89MP0001986_abnormal_taste_sensitivity1.01738233
90MP0001968_abnormal_touch/_nociception1.01050409
91MP0000678_abnormal_parathyroid_gland1.00191261
92MP0006054_spinal_hemorrhage0.99438587
93MP0001293_anophthalmia0.98458438
94MP0002249_abnormal_larynx_morphology0.98411008
95MP0000003_abnormal_adipose_tissue0.95638039
96MP0003195_calcinosis0.95061263
97MP0002160_abnormal_reproductive_system0.94752056
98MP0002080_prenatal_lethality0.94594618
99MP0000371_diluted_coat_color0.93868198
100MP0003984_embryonic_growth_retardation0.92966471
101MP0002102_abnormal_ear_morphology0.92606910
102MP0005164_abnormal_response_to0.90518521
103MP0002928_abnormal_bile_duct0.90365087
104MP0010386_abnormal_urinary_bladder0.89402990
105MP0002837_dystrophic_cardiac_calcinosis0.89397330
106MP0000470_abnormal_stomach_morphology0.88572766
107MP0009046_muscle_twitch0.88548762
108MP0000647_abnormal_sebaceous_gland0.88530318
109MP0000609_abnormal_liver_physiology0.88283412
110MP0003953_abnormal_hormone_level0.88140822
111MP0002088_abnormal_embryonic_growth/wei0.86802159
112MP0008058_abnormal_DNA_repair0.86422797
113MP0004019_abnormal_vitamin_homeostasis0.86021178
114MP0004133_heterotaxia0.85158907
115MP0002396_abnormal_hematopoietic_system0.84859817
116MP0000427_abnormal_hair_cycle0.84835914
117MP0000747_muscle_weakness0.84270182
118MP0002168_other_aberrant_phenotype0.84173904
119MP0002970_abnormal_white_adipose0.83908659
120MP0000538_abnormal_urinary_bladder0.83054661
121MP0002277_abnormal_respiratory_mucosa0.82834593
122MP0004197_abnormal_fetal_growth/weight/0.82672988
123MP0010307_abnormal_tumor_latency0.81694225
124MP0003699_abnormal_female_reproductive0.80399707
125MP0001270_distended_abdomen0.80357416
126MP0002006_tumorigenesis0.79566146
127MP0005332_abnormal_amino_acid0.79521942
128MP0002163_abnormal_gland_morphology0.78386586
129MP0001502_abnormal_circadian_rhythm0.78242240
130MP0005266_abnormal_metabolism0.77257407
131MP0002095_abnormal_skin_pigmentation0.77081992
132MP0005410_abnormal_fertilization0.76377268
133MP0002971_abnormal_brown_adipose0.74263214
134MP0001984_abnormal_olfaction0.74194741
135MP0009333_abnormal_splenocyte_physiolog0.74001095
136MP0005647_abnormal_sex_gland0.73756566
137MP0001661_extended_life_span0.73713968
138MP0010329_abnormal_lipoprotein_level0.73517005
139MP0008932_abnormal_embryonic_tissue0.72883312
140MP0001666_abnormal_nutrient_absorption0.72718410
141MP0009745_abnormal_behavioral_response0.72624272
142MP0002118_abnormal_lipid_homeostasis0.72442800
143MP0002148_abnormal_hypersensitivity_rea0.72374681
144MP0000350_abnormal_cell_proliferation0.71944954
145MP0009115_abnormal_fat_cell0.69859289
146MP0003935_abnormal_craniofacial_develop0.69700490
147MP0002734_abnormal_mechanical_nocicepti0.69391201
148MP0005508_abnormal_skeleton_morphology0.68653266
149MP0005451_abnormal_body_composition0.68456309
150MP0004185_abnormal_adipocyte_glucose0.68342568
151MP0003122_maternal_imprinting0.68129811
152MP0005187_abnormal_penis_morphology0.67896929
153MP0002069_abnormal_eating/drinking_beha0.66845738
154MP0003567_abnormal_fetal_cardiomyocyte0.66724592
155MP0002139_abnormal_hepatobiliary_system0.66401679
156MP0003077_abnormal_cell_cycle0.66323297
157MP0000613_abnormal_salivary_gland0.65662326
158MP0001145_abnormal_male_reproductive0.65414248
159MP0001765_abnormal_ion_homeostasis0.65288551
160MP0004134_abnormal_chest_morphology0.64623483
161MP0002229_neurodegeneration0.64576824
162MP0005376_homeostasis/metabolism_phenot0.64539888
163MP0003868_abnormal_feces_composition0.64162300
164MP0002138_abnormal_hepatobiliary_system0.63599589
165MP0005448_abnormal_energy_balance0.63107163
166MP0003633_abnormal_nervous_system0.62387708
167MP0001340_abnormal_eyelid_morphology0.61045693
168MP0003221_abnormal_cardiomyocyte_apopto0.59907047
169MP0002111_abnormal_tail_morphology0.58420252
170MP0000653_abnormal_sex_gland0.57537097
171MP0003137_abnormal_impulse_conducting0.57282692

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.13241588
2Abnormality of alanine metabolism (HP:0010916)6.13241588
3Hyperalaninemia (HP:0003348)6.13241588
4Facial hemangioma (HP:0000329)5.11403812
5Pustule (HP:0200039)4.66020659
6Large for gestational age (HP:0001520)4.61019995
7Dysautonomia (HP:0002459)4.41746150
8Congenital sensorineural hearing impairment (HP:0008527)4.33445423
9Turricephaly (HP:0000262)4.28637806
10Male infertility (HP:0003251)4.28255868
11Urinary glycosaminoglycan excretion (HP:0003541)4.27271441
12Mucopolysacchariduria (HP:0008155)4.27271441
13Constricted visual fields (HP:0001133)4.26584040
14Pancreatic islet-cell hyperplasia (HP:0004510)4.23875674
15Dysostosis multiplex (HP:0000943)4.20833701
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.09267358
17Rib fusion (HP:0000902)4.01063952
18Abnormality of mucopolysaccharide metabolism (HP:0011020)4.00801378
19Abnormality of polysaccharide metabolism (HP:0011012)4.00801378
20Abnormality of glycosaminoglycan metabolism (HP:0004371)4.00801378
21Alopecia of scalp (HP:0002293)3.96550210
22Concave nail (HP:0001598)3.74351237
23Abnormality of endocrine pancreas physiology (HP:0012093)3.70988602
24Abnormality of the pancreatic islet cells (HP:0006476)3.70988602
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.59997221
26Patchy hypopigmentation of hair (HP:0011365)3.56977066
27White forelock (HP:0002211)3.55616110
28Annular pancreas (HP:0001734)3.42815744
29Anteriorly placed anus (HP:0001545)3.42656203
30Rectovaginal fistula (HP:0000143)3.31537414
31Rectal fistula (HP:0100590)3.31537414
32Hyperglycemia (HP:0003074)3.30339634
33Hypomagnesemia (HP:0002917)3.29483263
34Intestinal fistula (HP:0100819)3.28853402
35Hypochromic microcytic anemia (HP:0004840)3.24232569
36Vaginal fistula (HP:0004320)3.23141302
37Polycythemia (HP:0001901)3.23022792
38Increased IgM level (HP:0003496)3.20561747
39Gout (HP:0001997)3.19964414
40Short humerus (HP:0005792)3.17029844
41Ketoacidosis (HP:0001993)3.13219565
42Orthostatic hypotension (HP:0001278)3.12537030
43Ulnar bowing (HP:0003031)3.10536734
44Capillary hemangiomas (HP:0005306)3.07434083
45Aplasia/hypoplasia of the humerus (HP:0006507)3.06493593
46Hyperinsulinemic hypoglycemia (HP:0000825)3.01646192
47Conjugated hyperbilirubinemia (HP:0002908)3.00610839
48Anorexia (HP:0002039)3.00209056
49Poikiloderma (HP:0001029)2.99383358
50Insulin-resistant diabetes mellitus (HP:0000831)2.95980212
51Intestinal atresia (HP:0011100)2.91108691
52Tongue fasciculations (HP:0001308)2.90874991
53Generalized aminoaciduria (HP:0002909)2.89441878
54Muscle fibrillation (HP:0010546)2.85471988
55Homocystinuria (HP:0002156)2.80429402
56Abnormality of homocysteine metabolism (HP:0010919)2.80429402
57Hypoglycemic seizures (HP:0002173)2.77834408
58Esophageal varix (HP:0002040)2.76056394
59Congenital hip dislocation (HP:0001374)2.68209901
60Abnormality of serum amino acid levels (HP:0003112)2.67392771
61Vertebral hypoplasia (HP:0008417)2.67201187
62Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.67201187
63Methylmalonic acidemia (HP:0002912)2.66905785
64Action tremor (HP:0002345)2.62834623
65Joint stiffness (HP:0001387)2.61459084
66Abnormality of sulfur amino acid metabolism (HP:0004339)2.60961645
67Coronal craniosynostosis (HP:0004440)2.57619356
68Abnormality of male internal genitalia (HP:0000022)2.54438853
69Cerebral aneurysm (HP:0004944)2.52384864
70Progressive neurologic deterioration (HP:0002344)2.51663871
71Abnormality of the aortic arch (HP:0012303)2.51337007
72Growth hormone excess (HP:0000845)2.50940857
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49925597
74Abnormality of magnesium homeostasis (HP:0004921)2.49556837
75Attenuation of retinal blood vessels (HP:0007843)2.48751903
76Hypoglycemic coma (HP:0001325)2.43022460
77Metaphyseal dysplasia (HP:0100255)2.42651257
78Heterochromia iridis (HP:0001100)2.40448635
79Absent radius (HP:0003974)2.37954223
80Type I diabetes mellitus (HP:0100651)2.37398016
81Tetany (HP:0001281)2.37137841
82Patellar aplasia (HP:0006443)2.36927142
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36769120
84Premature skin wrinkling (HP:0100678)2.35957271
85Short chin (HP:0000331)2.35039034
86Abnormal umbilical cord blood vessels (HP:0011403)2.34879040
87Single umbilical artery (HP:0001195)2.34879040
88Abnormality of the fetal cardiovascular system (HP:0010948)2.34879040
89Hyperglycinemia (HP:0002154)2.34244043
90Spontaneous hematomas (HP:0007420)2.32310309
91Asymmetric septal hypertrophy (HP:0001670)2.31318317
92Abnormality of the labia minora (HP:0012880)2.27233441
93Diaphragmatic weakness (HP:0009113)2.25976247
94Absent forearm bone (HP:0003953)2.25900596
95Aplasia involving forearm bones (HP:0009822)2.25900596
96Poor speech (HP:0002465)2.25596259
97Alacrima (HP:0000522)2.24105864
98Progressive muscle weakness (HP:0003323)2.23285325
99Shawl scrotum (HP:0000049)2.22148513
100Aplasia/Hypoplasia of the patella (HP:0006498)2.22122266
101Hypoalphalipoproteinemia (HP:0003233)2.21825291
102Methylmalonic aciduria (HP:0012120)2.21216632
103Lower limb hyperreflexia (HP:0002395)2.20689124
104Tubulointerstitial nephritis (HP:0001970)2.20440939
105Conjunctival telangiectasia (HP:0000524)2.18111790
106Hypothermia (HP:0002045)2.17847085
107Abnormal hemoglobin (HP:0011902)2.17822653
108Aplasia of the musculature (HP:0100854)2.17310176
109Abnormal autonomic nervous system physiology (HP:0012332)2.16316559
110Albinism (HP:0001022)2.15281835
111Late onset (HP:0003584)2.14882203
112Hematochezia (HP:0002573)2.13186570
113Abnormality of the basal ganglia (HP:0002134)2.12884707
114Hypercortisolism (HP:0001578)2.12309245
115Hyperglycinuria (HP:0003108)2.11981147
116Duplicated collecting system (HP:0000081)2.11871786
117Broad alveolar ridges (HP:0000187)2.10528750
118Exocrine pancreatic insufficiency (HP:0001738)2.07918704
119Prominent metopic ridge (HP:0005487)2.07480363
120Symptomatic seizures (HP:0011145)2.06581823
121Ketosis (HP:0001946)2.04959576
122Pendular nystagmus (HP:0012043)2.02259717
123Chronic hepatic failure (HP:0100626)1.99499698
124Insulin resistance (HP:0000855)1.98735220
125Generalized hyperpigmentation (HP:0007440)1.98333654
126Clumsiness (HP:0002312)1.98215275
127Hypotension (HP:0002615)1.98038173
128Split hand (HP:0001171)1.96844992
129Chorioretinal atrophy (HP:0000533)1.96521503
130Choanal stenosis (HP:0000452)1.96472028
131Myocardial infarction (HP:0001658)1.94866330
132Cystic hygroma (HP:0000476)1.93653488
133Reduced subcutaneous adipose tissue (HP:0003758)1.93615400
134Spinal muscular atrophy (HP:0007269)1.93398567
135Abnormality of the renal collecting system (HP:0004742)1.93111104
136Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92513346
137Abnormality of vitamin B metabolism (HP:0004340)1.91718664
138Abnormality of the metopic suture (HP:0005556)1.91430503
139Small for gestational age (HP:0001518)1.90844678
140Disproportionate short-trunk short stature (HP:0003521)1.90473638
141Muscular hypotonia of the trunk (HP:0008936)1.90092077
142Hyperparathyroidism (HP:0000843)1.87791813
143Hyperphosphatemia (HP:0002905)1.87791662
144Pulmonary embolism (HP:0002204)1.86617570
145Abnormality of liposaccharide metabolism (HP:0010968)1.85664156
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.85664156
147Abnormality of glycolipid metabolism (HP:0010969)1.85664156
148Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85158742
149Hypokinesia (HP:0002375)1.84852484
150Epidermoid cyst (HP:0200040)1.84579201
151Cavernous hemangioma (HP:0001048)1.84512212
152Basal ganglia calcification (HP:0002135)1.83749831
153Bowing of the arm (HP:0006488)1.83169938
154Bowed forearm bones (HP:0003956)1.83169938
155Type I transferrin isoform profile (HP:0003642)1.82353567
156Oligomenorrhea (HP:0000876)1.81940163
157Delayed gross motor development (HP:0002194)1.81203831
158Progressive macrocephaly (HP:0004481)1.81043585
159Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80760352
160Hypolipoproteinemia (HP:0010981)1.80636620
161Squamous cell carcinoma (HP:0002860)1.80248505
162Acute hepatic failure (HP:0006554)1.79826325
163Atrioventricular block (HP:0001678)1.79785722
164Pigmentary retinal degeneration (HP:0001146)1.79724192
165Hypotelorism (HP:0000601)1.79308870
166Increased serum pyruvate (HP:0003542)1.78976869
167Abnormal protein glycosylation (HP:0012346)1.78532783
168Abnormal glycosylation (HP:0012345)1.78532783
169Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78532783
170Abnormal protein N-linked glycosylation (HP:0012347)1.78532783
171Hepatic necrosis (HP:0002605)1.78494605
172Increased serum lactate (HP:0002151)1.78157698
173Hyperphosphaturia (HP:0003109)1.78049564
174Metabolic acidosis (HP:0001942)1.77057676
175Intention tremor (HP:0002080)1.76801326
176IgA deficiency (HP:0002720)1.75976884
177Polydipsia (HP:0001959)1.74342052
178Abnormal drinking behavior (HP:0030082)1.74342052
179Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73284944
180Thyroiditis (HP:0100646)1.73010998
181Neoplasm of the adrenal cortex (HP:0100641)1.71661772
182Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.70882167
183Glycosuria (HP:0003076)1.70357094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.96750497
2MAPK155.46146543
3ICK4.80372476
4DDR24.18112320
5PINK14.14184441
6MAP3K34.14023609
7MAP3K63.99067504
8MKNK23.60797659
9AKT33.43368616
10ACVR1B3.14360840
11TRIM282.95242923
12MAP3K112.58744370
13PRKD22.50823289
14MAP2K32.44977314
15TYRO32.40366438
16FGFR22.24706521
17LATS22.22054011
18EIF2AK32.21026885
19MATK2.19752357
20PDGFRA2.18257273
21FGR2.17000314
22MAP4K21.98428079
23UHMK11.84387282
24JAK31.73407136
25DYRK1B1.70423950
26CSK1.70346862
27DAPK11.64654029
28MKNK11.58579813
29EIF2AK11.56937999
30NTRK31.56529569
31TNIK1.56529374
32HIPK21.56193929
33PIM21.54161966
34BMX1.51575672
35PLK21.51166071
36INSRR1.50845923
37BMPR1B1.50621342
38CDK91.47001873
39MST41.38188200
40TRPM71.37215254
41ADRBK21.36922507
42MAP3K91.35021619
43ERN11.34849755
44GRK11.33248209
45TAOK31.32986104
46STK38L1.31517530
47TRIB31.29862134
48BRSK21.29859742
49CDC42BPA1.24335352
50PRKD31.24105729
51PRKAA11.23332160
52LATS11.19394019
53CDK71.16424725
54NUAK11.15012372
55FER1.13971383
56ERBB31.11877427
57MAPK111.10316347
58RAF11.10229114
59PHKG11.09315217
60PHKG21.09315217
61YES11.06905879
62DYRK31.06064870
63TAOK11.05642206
64MAP3K121.05176700
65ADRBK11.03260576
66KSR21.00991724
67MAP3K41.00281782
68PRKCE1.00080964
69BUB10.98295215
70CHEK20.97103024
71STK30.94639925
72NEK20.93851300
73BMPR20.92894097
74GSK3A0.92271921
75SGK2230.91546534
76SGK4940.91546534
77SGK20.91231703
78PIM10.91048099
79PASK0.85265931
80CSNK1A10.83426190
81BCKDK0.82681441
82PLK10.79041922
83MTOR0.75461691
84FGFR30.72023359
85IKBKB0.71389450
86PAK60.71221753
87RPS6KL10.70573384
88RPS6KC10.70573384
89ARAF0.69277602
90BRSK10.69140692
91STK390.68847001
92CDK60.66866384
93PLK30.66075854
94MAPKAPK30.65795919
95ABL20.65586521
96STK380.64753912
97BRAF0.61727817
98MYLK0.59922294
99PRKAA20.59585170
100WNK40.58481211
101STK160.57992104
102PTK20.57385179
103RPS6KA60.57291055
104RPS6KB20.56116155
105STK240.55152438
106MAP2K70.54724959
107CLK10.54507087
108WNK30.54264895
109STK40.51368910
110GRK70.50948478
111NEK60.49513655
112NTRK20.49468976
113OXSR10.48801796
114PDGFRB0.48632577
115SIK30.47996856
116PRKCG0.46726939
117SGK30.46708531
118JAK20.46002425
119PRKCQ0.45824444
120BCR0.45309595
121PDK20.43308215
122MAPK100.43137867
123ALK0.42521362
124MAP2K10.42458828
125CAMK2G0.41854003
126JAK10.41580244
127IRAK10.41194691
128WEE10.40816638
129RPS6KA10.40767885
130EPHA20.40061562
131ABL10.39119908
132CASK0.38596629
133CDK20.38291865
134CCNB10.37501112
135PRKCI0.37357663
136DAPK20.36349506
137PRKCA0.35194057
138CSNK1G10.34736983
139NTRK10.33971816
140RPS6KB10.33660576
141ERBB40.33333104
142MUSK0.32976912
143FLT30.32742472
144AURKA0.32203071
145SIK20.31645604
146CSNK1G30.31112086
147CSNK1G20.31089942
148MARK20.30170484
149MAP3K10.29673225
150PAK40.29046839
151PRPF4B0.28948017
152EPHB20.28386306
153MAPK140.28298774
154MAPK10.27169337
155MAPK30.27029733
156CAMK2B0.26673679
157EIF2AK20.25992724
158MAP3K50.25562554
159PRKD10.25316679
160PTK2B0.25120526
161CAMK2D0.24047691
162PAK30.23849857
163DYRK20.23008989
164EGFR0.22763377
165CHEK10.22751057
166PLK40.22069727
167MELK0.21716096
168PRKCH0.20901939
169CSNK2A10.20365516
170CAMK2A0.19844801
171TAOK20.19743764

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.22960869
2Fatty acid biosynthesis_Homo sapiens_hsa000614.66756266
3Collecting duct acid secretion_Homo sapiens_hsa049663.41263733
4Folate biosynthesis_Homo sapiens_hsa007903.28948502
5Circadian rhythm_Homo sapiens_hsa047103.27100147
6Vitamin B6 metabolism_Homo sapiens_hsa007503.03294425
7One carbon pool by folate_Homo sapiens_hsa006702.91997838
8Base excision repair_Homo sapiens_hsa034102.68165321
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.33396499
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.32043841
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24914453
12SNARE interactions in vesicular transport_Homo sapiens_hsa041302.09751591
13mTOR signaling pathway_Homo sapiens_hsa041502.07659033
14Arginine and proline metabolism_Homo sapiens_hsa003302.05374821
15Mismatch repair_Homo sapiens_hsa034301.99224451
16Proteasome_Homo sapiens_hsa030501.84364697
17Longevity regulating pathway - mammal_Homo sapiens_hsa042111.67757371
18Fatty acid metabolism_Homo sapiens_hsa012121.63308023
19Biosynthesis of amino acids_Homo sapiens_hsa012301.60895715
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55230225
21Fatty acid elongation_Homo sapiens_hsa000621.53573085
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52476359
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51913689
24Lysosome_Homo sapiens_hsa041421.46326062
25Protein export_Homo sapiens_hsa030601.45407116
26Sulfur relay system_Homo sapiens_hsa041221.45032148
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38161833
28p53 signaling pathway_Homo sapiens_hsa041151.37107064
29Peroxisome_Homo sapiens_hsa041461.36730954
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36275575
31Oxidative phosphorylation_Homo sapiens_hsa001901.30538978
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.28567054
33RNA transport_Homo sapiens_hsa030131.24459149
34Propanoate metabolism_Homo sapiens_hsa006401.21296792
35Rheumatoid arthritis_Homo sapiens_hsa053231.20250993
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18259892
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.17849651
38Insulin secretion_Homo sapiens_hsa049111.17294352
39Galactose metabolism_Homo sapiens_hsa000521.16451994
40Bladder cancer_Homo sapiens_hsa052191.14110485
41Arginine biosynthesis_Homo sapiens_hsa002201.11701212
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11644803
43Cell cycle_Homo sapiens_hsa041101.09920592
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08397161
45Hedgehog signaling pathway_Homo sapiens_hsa043401.06934614
46Lysine degradation_Homo sapiens_hsa003101.06783658
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06419763
48GABAergic synapse_Homo sapiens_hsa047271.04736042
49Sphingolipid metabolism_Homo sapiens_hsa006001.03376087
50Synaptic vesicle cycle_Homo sapiens_hsa047211.03080096
51Notch signaling pathway_Homo sapiens_hsa043301.02957293
52Oocyte meiosis_Homo sapiens_hsa041141.02599633
53Regulation of autophagy_Homo sapiens_hsa041401.02007163
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01300794
55Hippo signaling pathway_Homo sapiens_hsa043900.99745395
56Fructose and mannose metabolism_Homo sapiens_hsa000510.99282947
57N-Glycan biosynthesis_Homo sapiens_hsa005100.96519253
58Selenocompound metabolism_Homo sapiens_hsa004500.96341705
59mRNA surveillance pathway_Homo sapiens_hsa030150.95450421
60Other glycan degradation_Homo sapiens_hsa005110.93217845
61Sulfur metabolism_Homo sapiens_hsa009200.92930801
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91819795
63Dorso-ventral axis formation_Homo sapiens_hsa043200.91553673
64Basal transcription factors_Homo sapiens_hsa030220.90262284
65Adherens junction_Homo sapiens_hsa045200.89473335
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89061005
67Ether lipid metabolism_Homo sapiens_hsa005650.83152535
68Morphine addiction_Homo sapiens_hsa050320.83017541
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82258761
70Taste transduction_Homo sapiens_hsa047420.76906265
71Retinol metabolism_Homo sapiens_hsa008300.76304998
72Glycerolipid metabolism_Homo sapiens_hsa005610.75354393
73Insulin signaling pathway_Homo sapiens_hsa049100.74943595
74Linoleic acid metabolism_Homo sapiens_hsa005910.74086847
75Choline metabolism in cancer_Homo sapiens_hsa052310.73309280
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71269375
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71043842
78AMPK signaling pathway_Homo sapiens_hsa041520.70313100
79TGF-beta signaling pathway_Homo sapiens_hsa043500.69354097
80Metabolic pathways_Homo sapiens_hsa011000.69157205
81Fat digestion and absorption_Homo sapiens_hsa049750.68850006
82DNA replication_Homo sapiens_hsa030300.68505940
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68414180
84Nucleotide excision repair_Homo sapiens_hsa034200.68085557
85Nicotine addiction_Homo sapiens_hsa050330.66999387
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66567718
87Glutathione metabolism_Homo sapiens_hsa004800.65518848
88Prion diseases_Homo sapiens_hsa050200.65505380
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65077873
90VEGF signaling pathway_Homo sapiens_hsa043700.62110758
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.60557384
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59296084
93Legionellosis_Homo sapiens_hsa051340.59260989
94Serotonergic synapse_Homo sapiens_hsa047260.59183158
95Type II diabetes mellitus_Homo sapiens_hsa049300.58369360
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58219433
97Dopaminergic synapse_Homo sapiens_hsa047280.57862881
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57098961
99Glucagon signaling pathway_Homo sapiens_hsa049220.57022723
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55148915
101Tryptophan metabolism_Homo sapiens_hsa003800.54551812
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.54001536
103Starch and sucrose metabolism_Homo sapiens_hsa005000.53862313
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53680108
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52931987
106Vitamin digestion and absorption_Homo sapiens_hsa049770.52305223
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52270809
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51814567
109Chemical carcinogenesis_Homo sapiens_hsa052040.51661809
110Phototransduction_Homo sapiens_hsa047440.51549165
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50780623
112beta-Alanine metabolism_Homo sapiens_hsa004100.50278332
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49646976
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.48547612
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46973061
116Thyroid cancer_Homo sapiens_hsa052160.46855687
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45818536
118RNA degradation_Homo sapiens_hsa030180.44229642
119Complement and coagulation cascades_Homo sapiens_hsa046100.43787668
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43573334
121Butanoate metabolism_Homo sapiens_hsa006500.43337094
122Wnt signaling pathway_Homo sapiens_hsa043100.43207861
123Homologous recombination_Homo sapiens_hsa034400.42884303
124Pancreatic secretion_Homo sapiens_hsa049720.42327105
125Insulin resistance_Homo sapiens_hsa049310.41996333
126Prolactin signaling pathway_Homo sapiens_hsa049170.41556210
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41538670
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41209556
129Estrogen signaling pathway_Homo sapiens_hsa049150.41163581
130RNA polymerase_Homo sapiens_hsa030200.40534666
131Caffeine metabolism_Homo sapiens_hsa002320.39161479
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38727707
133Ovarian steroidogenesis_Homo sapiens_hsa049130.37647418
134ABC transporters_Homo sapiens_hsa020100.36498830
135Nitrogen metabolism_Homo sapiens_hsa009100.36393874
136Circadian entrainment_Homo sapiens_hsa047130.34790007
137Mineral absorption_Homo sapiens_hsa049780.34655767
138Vibrio cholerae infection_Homo sapiens_hsa051100.34565576
139ErbB signaling pathway_Homo sapiens_hsa040120.34076654
140Glutamatergic synapse_Homo sapiens_hsa047240.33327767
141Non-homologous end-joining_Homo sapiens_hsa034500.33099348
142Type I diabetes mellitus_Homo sapiens_hsa049400.32721161
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.32668486
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32307040
145Fanconi anemia pathway_Homo sapiens_hsa034600.32246459
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31593644
147Prostate cancer_Homo sapiens_hsa052150.31578964
148FoxO signaling pathway_Homo sapiens_hsa040680.31338264
149Gap junction_Homo sapiens_hsa045400.29799080
150Colorectal cancer_Homo sapiens_hsa052100.26477524
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26340632
152Steroid biosynthesis_Homo sapiens_hsa001000.26295742
153Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24868266

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »