FIGLA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)8.96831236
2protein kinase C signaling (GO:0070528)7.76056436
3regulation of female gonad development (GO:2000194)7.58749396
4regulation of meiosis I (GO:0060631)7.45497079
5protein K6-linked ubiquitination (GO:0085020)7.31996116
6positive regulation of humoral immune response (GO:0002922)7.17159890
7male meiosis (GO:0007140)7.03654788
8regulation of retinoic acid receptor signaling pathway (GO:0048385)7.03050642
9negative regulation of meiosis (GO:0045835)6.93155863
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.70634811
11histone H3-K9 demethylation (GO:0033169)6.50522688
12reproduction (GO:0000003)6.47651325
13base-excision repair, AP site formation (GO:0006285)6.04962260
14regulation of meiosis (GO:0040020)6.00407342
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.00350071
16positive regulation of meiosis (GO:0045836)5.99859806
17synaptonemal complex assembly (GO:0007130)5.98258347
18binding of sperm to zona pellucida (GO:0007339)5.81104638
19gene silencing by RNA (GO:0031047)5.75892293
20positive regulation of histone H3-K4 methylation (GO:0051571)5.69672673
21positive regulation of meiotic cell cycle (GO:0051446)5.56675986
22synaptonemal complex organization (GO:0070193)5.55999615
23ribosomal small subunit assembly (GO:0000028)5.55985653
24mitotic chromosome condensation (GO:0007076)5.55749815
25female gamete generation (GO:0007292)5.49294091
26glycine transport (GO:0015816)5.44909161
27synapsis (GO:0007129)5.26317871
28citrulline biosynthetic process (GO:0019240)5.11458239
29retinal cone cell development (GO:0046549)5.10444775
30histone H2A ubiquitination (GO:0033522)5.08488101
31male meiosis I (GO:0007141)5.07606751
32ribosomal small subunit biogenesis (GO:0042274)5.05119475
33negative regulation of meiotic cell cycle (GO:0051447)5.00949129
34regulation of steroid hormone secretion (GO:2000831)4.91586553
35mitotic metaphase plate congression (GO:0007080)4.87083814
36pyrimidine nucleotide catabolic process (GO:0006244)4.83913223
37single fertilization (GO:0007338)4.79817454
38regulation of meiotic cell cycle (GO:0051445)4.76852568
39regulation of acrosome reaction (GO:0060046)4.70673070
40histone H2A monoubiquitination (GO:0035518)4.70199141
41positive regulation of reproductive process (GO:2000243)4.69794076
42kinetochore assembly (GO:0051382)4.65473059
43attachment of spindle microtubules to kinetochore (GO:0008608)4.58919677
44DNA methylation (GO:0006306)4.57138645
45DNA alkylation (GO:0006305)4.57138645
46sperm-egg recognition (GO:0035036)4.56079715
47meiotic nuclear division (GO:0007126)4.52366998
48chaperone-mediated protein transport (GO:0072321)4.49592417
49* oocyte development (GO:0048599)4.48646399
50meiotic cell cycle (GO:0051321)4.41551543
51kinetochore organization (GO:0051383)4.41124117
52oogenesis (GO:0048477)4.40833776
53positive regulation of uterine smooth muscle contraction (GO:0070474)4.37493627
54regulation of cell maturation (GO:1903429)4.35288002
55metaphase plate congression (GO:0051310)4.34740053
56negative regulation of smooth muscle cell differentiation (GO:0051151)4.32341956
57protein localization to chromosome, centromeric region (GO:0071459)4.29031343
58meiosis I (GO:0007127)4.25802277
59regulation of exit from mitosis (GO:0007096)4.23870415
60regulation of hypersensitivity (GO:0002883)4.23402892
61oocyte maturation (GO:0001556)4.19660382
62regulation of calcium ion-dependent exocytosis (GO:0017158)4.10189642
63positive regulation of gastrulation (GO:2000543)4.07332709
64protein localization to kinetochore (GO:0034501)3.99460833
65chromosome organization involved in meiosis (GO:0070192)3.97089081
66regulation of reproductive process (GO:2000241)3.93252685
67establishment of chromosome localization (GO:0051303)3.92079375
68N-terminal protein amino acid acetylation (GO:0006474)3.91611832
69gene silencing (GO:0016458)3.82464184
70notochord development (GO:0030903)3.80425216
71regulation of female receptivity (GO:0045924)3.78597523
72positive regulation of mitotic sister chromatid separation (GO:1901970)3.76231217
73positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.76231217
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.76231217
75multicellular organism reproduction (GO:0032504)3.74698878
76L-amino acid import (GO:0043092)3.72609960
77histone lysine demethylation (GO:0070076)3.70319337
78chromatin remodeling at centromere (GO:0031055)3.69169835
79cell-cell recognition (GO:0009988)3.66795090
80regulation of phospholipid biosynthetic process (GO:0071071)3.66691783
81regulation of histone H3-K9 methylation (GO:0051570)3.63897362
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61346863
83regulation of cytokine production involved in inflammatory response (GO:1900015)3.60765964
84hyperosmotic salinity response (GO:0042538)3.59839710
85DNA modification (GO:0006304)3.59629129
86positive regulation of chromosome segregation (GO:0051984)3.59512111
87protein localization to chromosome (GO:0034502)3.58145439
88proteasome assembly (GO:0043248)3.57282791
89positive regulation of histone methylation (GO:0031062)3.56208617
90citrulline metabolic process (GO:0000052)3.53955105
91primitive streak formation (GO:0090009)3.53038004
92CENP-A containing nucleosome assembly (GO:0034080)3.51524264
93histone demethylation (GO:0016577)3.50668501
94meiotic chromosome segregation (GO:0045132)3.50210153
95mitotic sister chromatid segregation (GO:0000070)3.49595354
96centriole replication (GO:0007099)3.48128097
97meiotic cell cycle process (GO:1903046)3.47180852
98regulation of histone H3-K4 methylation (GO:0051569)3.47004906
99regulation of DNA methylation (GO:0044030)3.46130679
100protein complex localization (GO:0031503)3.44098523
101DNA methylation or demethylation (GO:0044728)3.43719085
102DNA damage induced protein phosphorylation (GO:0006975)3.42932154
103regulation of sister chromatid cohesion (GO:0007063)3.41896622
104histone exchange (GO:0043486)3.40092625
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.34830947
106regulation of spindle organization (GO:0090224)3.34337169
107aggressive behavior (GO:0002118)3.33921779
108pre-miRNA processing (GO:0031054)3.33280646
109pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.33122968
110DNA replication-independent nucleosome organization (GO:0034724)3.30041290
111DNA replication-independent nucleosome assembly (GO:0006336)3.30041290
112positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.29508728
113positive regulation of male gonad development (GO:2000020)3.29084797
114maturation of SSU-rRNA (GO:0030490)3.27921504
115regulation of uterine smooth muscle contraction (GO:0070472)3.27556970
116protein K11-linked ubiquitination (GO:0070979)3.25016177
117phosphorelay signal transduction system (GO:0000160)3.23901764
118ovulation cycle (GO:0042698)3.23045295
119female mating behavior (GO:0060180)3.20614009
120negative regulation of nuclear division (GO:0051784)3.20072953
121phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.19779181
122protein dealkylation (GO:0008214)3.17275881
123protein demethylation (GO:0006482)3.17275881
124regulation of steroid hormone biosynthetic process (GO:0090030)3.12513847
125regulation of histone methylation (GO:0031060)3.12135993
126DNA replication-dependent nucleosome assembly (GO:0006335)3.10409690
127DNA replication-dependent nucleosome organization (GO:0034723)3.10409690
128fertilization (GO:0009566)3.10228369
129spindle checkpoint (GO:0031577)3.09899419
130positive regulation of megakaryocyte differentiation (GO:0045654)3.09285198
131negative regulation of histone methylation (GO:0031061)3.08408361
132negative regulation of histone modification (GO:0031057)3.07600064
133protein deneddylation (GO:0000338)3.06716373
134labyrinthine layer development (GO:0060711)3.06347055
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06027409
136translesion synthesis (GO:0019985)3.05553876
137negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.05043856
138regulation of chromatin silencing (GO:0031935)3.02547677
139negative regulation of cell division (GO:0051782)3.01062137
140chromosome segregation (GO:0007059)3.00831244
141nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.00781842
142negative regulation of reproductive process (GO:2000242)3.00520891
143DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.97409753
144mitotic nuclear envelope disassembly (GO:0007077)2.92669311
145ribonucleoprotein complex biogenesis (GO:0022613)2.92140987
146chromatin assembly or disassembly (GO:0006333)2.91219208
147negative regulation of mitotic sister chromatid separation (GO:2000816)2.88939380
148negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88939380
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88939380
150negative regulation of sister chromatid segregation (GO:0033046)2.88939380
151regulation of chromosome segregation (GO:0051983)2.88899776
152regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88613359
153peptidyl-arginine modification (GO:0018195)2.88409632
154negative regulation of chromosome segregation (GO:0051985)2.88049833
155positive regulation of T cell apoptotic process (GO:0070234)2.87924366
156mitotic spindle assembly checkpoint (GO:0007094)2.84954636
157spliceosomal complex assembly (GO:0000245)2.83928624
158DNA replication checkpoint (GO:0000076)2.83025349
159piRNA metabolic process (GO:0034587)14.2355782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.70812596
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.64979784
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.05607466
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.01753020
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80558217
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.54154516
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52386918
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.39351902
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10615614
10AR_21909140_ChIP-Seq_LNCAP_Human3.04248601
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.89510676
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.88435009
13MYC_18940864_ChIP-ChIP_HL60_Human2.81647440
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74302981
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.67387729
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.66645886
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.66645886
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.66645886
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56558912
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.48319180
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.39586351
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.31733877
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28495592
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28142800
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26661818
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.15293641
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14267992
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.13858864
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.05405197
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.03008730
31EZH2_22144423_ChIP-Seq_EOC_Human15.5426576
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.96564444
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94725597
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.94082883
35GBX2_23144817_ChIP-Seq_PC3_Human1.93961181
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.88031767
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.87064624
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83751803
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82394827
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80939937
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79730933
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72708746
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71656828
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66041855
45XRN2_22483619_ChIP-Seq_HELA_Human1.63920016
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62755903
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60776274
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59097361
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54839728
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54070362
51RNF2_27304074_Chip-Seq_NSC_Mouse1.52249948
52GABP_19822575_ChIP-Seq_HepG2_Human1.50485917
53ZNF263_19887448_ChIP-Seq_K562_Human1.50381512
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49742096
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48451646
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.44079983
57NANOG_21062744_ChIP-ChIP_HESCs_Human1.42015954
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.40498953
59RUNX1_26923725_Chip-Seq_HPCs_Mouse1.38356015
60TTF2_22483619_ChIP-Seq_HELA_Human1.36639233
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34939514
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33611929
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33605146
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31537120
65DCP1A_22483619_ChIP-Seq_HELA_Human1.31386316
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28649387
67VDR_23849224_ChIP-Seq_CD4+_Human1.27703922
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.27669055
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25927423
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24936985
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.24928130
72TCF4_23295773_ChIP-Seq_U87_Human1.24042313
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21654410
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21039824
75NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20878053
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17330535
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16711652
78IRF1_19129219_ChIP-ChIP_H3396_Human1.15901947
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15096483
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14440219
81CIITA_25753668_ChIP-Seq_RAJI_Human1.11780471
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10523853
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10488561
84TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10319077
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10093592
86AR_25329375_ChIP-Seq_VCAP_Human1.08893151
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.08686564
88NANOG_20526341_ChIP-Seq_ESCs_Human1.08559583
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06623046
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06520833
91CBP_20019798_ChIP-Seq_JUKART_Human1.04819538
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04819538
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04771090
94* SMAD4_21799915_ChIP-Seq_A2780_Human1.03387223
95GF1_26923725_Chip-Seq_HPCs_Mouse1.03219576
96RUNX2_22187159_ChIP-Seq_PCA_Human1.01302587
97KDM5A_27292631_Chip-Seq_BREAST_Human1.01217117
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.99690952
99FOXP3_21729870_ChIP-Seq_TREG_Human0.99568793
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99206193
101NFYA_21822215_ChIP-Seq_K562_Human0.99134596
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97863589
103CBP_21632823_ChIP-Seq_H3396_Human0.97234175
104GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96362531
105ETV1_20927104_ChIP-Seq_GIST48_Human0.96057134
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95904317
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95353058
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95277435
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94965514
110ZNF274_21170338_ChIP-Seq_K562_Hela0.94845162
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94561350
112CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94298661
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94099115
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93757036
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93629154
116STAT3_23295773_ChIP-Seq_U87_Human0.93188142
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93150135
118NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92245273
119PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90821705
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90170274
121EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90153452
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89017472
123* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88745467
124RBPJ_21746931_ChIP-Seq_IB4_Human0.87807220
125SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87471678
126TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.86602284
127* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.85596964
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.84763955
129POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84579346
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84501752
131NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84470032
132HNFA_21074721_ChIP-Seq_CACO-2_Human0.83210407
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82681169
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82512868
135GATA3_21867929_ChIP-Seq_TH1_Mouse0.82371850
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82295174
137PHF8_20622853_ChIP-Seq_HELA_Human0.81465786
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81248705
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81160082
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81160082
141VDR_22108803_ChIP-Seq_LS180_Human0.80737355
142KLF4_19829295_ChIP-Seq_ESCs_Human0.80730093
143TP53_22573176_ChIP-Seq_HFKS_Human0.79547128
144TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79399624
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79288634
146SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79264123
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79176164
148GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79002226
149CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78942374
150POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78814418
151SMRT_27268052_Chip-Seq_Bcells_Human0.78518782
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78090134
153P300_19829295_ChIP-Seq_ESCs_Human0.77908498
154TAL1_26923725_Chip-Seq_HPCs_Mouse0.77733714
155REST_19997604_ChIP-ChIP_NEURONS_Mouse0.76281689
156EWS_26573619_Chip-Seq_HEK293_Human0.75829613
157HTT_18923047_ChIP-ChIP_STHdh_Human0.75587587
158SALL4_22934838_ChIP-ChIP_CD34+_Human0.75324333
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74509500
160GATA3_26560356_Chip-Seq_TH1_Human0.73165502
161BCAT_22108803_ChIP-Seq_LS180_Human0.70028732
162SMAD3_21741376_ChIP-Seq_EPCs_Human0.69409796
163TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.69308152
164REST_21632747_ChIP-Seq_MESCs_Mouse0.67454498
165CTBP2_25329375_ChIP-Seq_LNCAP_Human0.67213659
166NCOR_22424771_ChIP-Seq_293T_Human0.66611452
167PKCTHETA_26484144_Chip-Seq_BREAST_Human0.65271769
168MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.65227918
169* EZH2_27304074_Chip-Seq_ESCs_Mouse0.65170418
170TCF4_22108803_ChIP-Seq_LS180_Human0.64049483
171OCT4_19829295_ChIP-Seq_ESCs_Human0.63250688
172MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.63057535
173NR3C1_23031785_ChIP-Seq_PC12_Mouse0.62679808
174BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.62232845
175* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.61069111
176KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.60134258
177SOX2_21211035_ChIP-Seq_LN229_Gbm0.60103750
178TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.59589887
179SMAD3_21741376_ChIP-Seq_ESCs_Human0.58554465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.86111282
2MP0003646_muscle_fatigue6.16930226
3MP0003718_maternal_effect5.65245041
4MP0010094_abnormal_chromosome_stability3.78297275
5MP0003693_abnormal_embryo_hatching3.72188638
6MP0008789_abnormal_olfactory_epithelium3.45799208
7MP0004957_abnormal_blastocyst_morpholog3.34247453
8MP0005499_abnormal_olfactory_system3.21150518
9MP0005394_taste/olfaction_phenotype3.21150518
10* MP0002210_abnormal_sex_determination3.15118299
11* MP0001929_abnormal_gametogenesis3.11948650
12MP0003111_abnormal_nucleus_morphology2.90008640
13* MP0000653_abnormal_sex_gland2.79297802
14MP0003077_abnormal_cell_cycle2.64814862
15* MP0003699_abnormal_female_reproductive2.51111619
16MP0005395_other_phenotype2.42383570
17MP0001145_abnormal_male_reproductive2.37038170
18* MP0001119_abnormal_female_reproductive2.34440222
19MP0003879_abnormal_hair_cell2.29993048
20MP0010030_abnormal_orbit_morphology2.20160547
21MP0002138_abnormal_hepatobiliary_system2.15461905
22MP0002653_abnormal_ependyma_morphology2.13257013
23MP0003136_yellow_coat_color2.05014193
24MP0005410_abnormal_fertilization2.03382098
25MP0003315_abnormal_perineum_morphology2.01433884
26MP0005451_abnormal_body_composition2.00549071
27MP0000579_abnormal_nail_morphology1.94643445
28MP0002234_abnormal_pharynx_morphology1.82577117
29MP0008932_abnormal_embryonic_tissue1.76174791
30* MP0002161_abnormal_fertility/fecundity1.75597739
31MP0003195_calcinosis1.74934609
32MP0001529_abnormal_vocalization1.72223864
33MP0003183_abnormal_peptide_metabolism1.69553899
34MP0006292_abnormal_olfactory_placode1.65115667
35MP0005187_abnormal_penis_morphology1.65051343
36MP0003698_abnormal_male_reproductive1.56761067
37MP0005646_abnormal_pituitary_gland1.55921219
38MP0010307_abnormal_tumor_latency1.54298969
39MP0008058_abnormal_DNA_repair1.51815885
40MP0000566_synostosis1.47207910
41MP0010368_abnormal_lymphatic_system1.45223101
42MP0003123_paternal_imprinting1.45146638
43MP0010234_abnormal_vibrissa_follicle1.42699857
44MP0000427_abnormal_hair_cycle1.41179889
45MP0009379_abnormal_foot_pigmentation1.39742876
46MP0003950_abnormal_plasma_membrane1.37691580
47MP0005360_urolithiasis1.36945362
48MP0008995_early_reproductive_senescence1.33399257
49MP0000631_abnormal_neuroendocrine_gland1.31204182
50MP0001730_embryonic_growth_arrest1.31063660
51MP0000350_abnormal_cell_proliferation1.30569389
52MP0003937_abnormal_limbs/digits/tail_de1.30364943
53MP0002085_abnormal_embryonic_tissue1.29178293
54MP0001986_abnormal_taste_sensitivity1.28097828
55MP0000678_abnormal_parathyroid_gland1.27771452
56MP0008057_abnormal_DNA_replication1.25480714
57MP0006276_abnormal_autonomic_nervous1.19705168
58MP0003121_genomic_imprinting1.18082290
59MP0002332_abnormal_exercise_endurance1.17660659
60MP0005257_abnormal_intraocular_pressure1.10311654
61MP0002295_abnormal_pulmonary_circulatio1.08572561
62MP0000762_abnormal_tongue_morphology1.08441778
63MP0009697_abnormal_copulation1.05632752
64MP0003453_abnormal_keratinocyte_physiol1.03719011
65MP0004859_abnormal_synaptic_plasticity1.03092011
66MP0002233_abnormal_nose_morphology1.02705009
67MP0000613_abnormal_salivary_gland1.02288804
68MP0001664_abnormal_digestion1.01911831
69MP0001502_abnormal_circadian_rhythm1.00624020
70MP0001672_abnormal_embryogenesis/_devel0.97240171
71MP0005380_embryogenesis_phenotype0.97240171
72MP0003755_abnormal_palate_morphology0.97169278
73MP0002638_abnormal_pupillary_reflex0.96631670
74MP0002249_abnormal_larynx_morphology0.96556357
75MP0003705_abnormal_hypodermis_morpholog0.94823407
76MP0001666_abnormal_nutrient_absorption0.94321014
77MP0003252_abnormal_bile_duct0.93524912
78MP0002084_abnormal_developmental_patter0.92195733
79MP0006072_abnormal_retinal_apoptosis0.91707909
80MP0002272_abnormal_nervous_system0.89977730
81MP0010678_abnormal_skin_adnexa0.89864481
82MP0006036_abnormal_mitochondrial_physio0.89129358
83MP0003787_abnormal_imprinting0.85659463
84MP0000049_abnormal_middle_ear0.84515972
85MP0003786_premature_aging0.84378704
86MP0000465_gastrointestinal_hemorrhage0.83189700
87MP0002932_abnormal_joint_morphology0.82750468
88MP0002282_abnormal_trachea_morphology0.80417105
89MP0001905_abnormal_dopamine_level0.80001838
90MP0002019_abnormal_tumor_incidence0.79868064
91MP0001697_abnormal_embryo_size0.77104769
92MP0003868_abnormal_feces_composition0.76895317
93MP0004185_abnormal_adipocyte_glucose0.76581698
94MP0001915_intracranial_hemorrhage0.75699868
95MP0001984_abnormal_olfaction0.75694711
96MP0005389_reproductive_system_phenotype0.74548326
97MP0003890_abnormal_embryonic-extraembry0.73351214
98MP0001919_abnormal_reproductive_system0.71605901
99MP0002736_abnormal_nociception_after0.71517593
100MP0005408_hypopigmentation0.71488942
101MP0002127_abnormal_cardiovascular_syste0.71176714
102MP0004145_abnormal_muscle_electrophysio0.70723499
103MP0002080_prenatal_lethality0.69038863
104MP0002269_muscular_atrophy0.68309802
105MP0005266_abnormal_metabolism0.66208020
106MP0004036_abnormal_muscle_relaxation0.63859745
107MP0000733_abnormal_muscle_development0.63846426
108MP0001293_anophthalmia0.63009644
109MP0003941_abnormal_skin_development0.62958263
110MP0005551_abnormal_eye_electrophysiolog0.60928918
111MP0003861_abnormal_nervous_system0.60773435
112MP0000639_abnormal_adrenal_gland0.60528178
113MP0002796_impaired_skin_barrier0.60095508
114MP0005085_abnormal_gallbladder_physiolo0.59545836
115MP0001324_abnormal_eye_pigmentation0.58547274
116MP0005076_abnormal_cell_differentiation0.57765138
117MP0010352_gastrointestinal_tract_polyps0.56557196
118MP0002139_abnormal_hepatobiliary_system0.56433032
119MP0001963_abnormal_hearing_physiology0.56259050
120MP0003984_embryonic_growth_retardation0.55917418
121MP0002088_abnormal_embryonic_growth/wei0.52809668
122MP0003959_abnormal_lean_body0.52247950
123MP0002735_abnormal_chemical_nociception0.51384526
124MP0002086_abnormal_extraembryonic_tissu0.51334349
125MP0001881_abnormal_mammary_gland0.50420523
126MP0002160_abnormal_reproductive_system0.49673438
127MP0003186_abnormal_redox_activity0.48968583
128MP0001286_abnormal_eye_development0.48445145
129MP0000490_abnormal_crypts_of0.47385129
130MP0008007_abnormal_cellular_replicative0.47364492
131MP0004142_abnormal_muscle_tone0.47301041
132MP0009840_abnormal_foam_cell0.46990949
133MP0000313_abnormal_cell_death0.46805606
134MP0003935_abnormal_craniofacial_develop0.46797053
135MP0002751_abnormal_autonomic_nervous0.46667891
136MP0005501_abnormal_skin_physiology0.46258525
137MP0003936_abnormal_reproductive_system0.45243017
138MP0005647_abnormal_sex_gland0.44707627
139MP0003119_abnormal_digestive_system0.44106234
140MP0000955_abnormal_spinal_cord0.43106873
141MP0005075_abnormal_melanosome_morpholog0.42346907
142MP0004043_abnormal_pH_regulation0.41493177
143MP0002734_abnormal_mechanical_nocicepti0.40859975
144MP0003221_abnormal_cardiomyocyte_apopto0.40782679
145MP0000383_abnormal_hair_follicle0.40072669
146MP0002873_normal_phenotype0.38994241
147MP0002090_abnormal_vision0.38857879
148MP0002169_no_abnormal_phenotype0.38530623
149MP0002089_abnormal_postnatal_growth/wei0.38409664
150MP0004381_abnormal_hair_follicle0.36506489

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.08447254
2Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.57745599
3Chromsome breakage (HP:0040012)5.41528698
4Breast hypoplasia (HP:0003187)4.99618144
5Abdominal situs inversus (HP:0003363)4.88484836
6Abnormality of abdominal situs (HP:0011620)4.88484836
7Cortical dysplasia (HP:0002539)4.87744602
8Abnormality of the labia minora (HP:0012880)4.74051335
9Osteomalacia (HP:0002749)4.73363991
10Male infertility (HP:0003251)4.60488548
11Abnormal number of erythroid precursors (HP:0012131)4.60351081
12Impulsivity (HP:0100710)4.46555693
13Abnormality of cells of the erythroid lineage (HP:0012130)4.37582755
14Lip pit (HP:0100267)4.35134210
15Oligodactyly (hands) (HP:0001180)4.25122927
16Chromosomal breakage induced by crosslinking agents (HP:0003221)4.21399202
17Hypophosphatemic rickets (HP:0004912)4.19603533
18Infertility (HP:0000789)4.03018439
19Malnutrition (HP:0004395)4.00365307
20Gonadotropin excess (HP:0000837)3.86877687
21Median cleft lip (HP:0000161)3.70077874
22Amniotic constriction ring (HP:0009775)3.68214017
23Abnormality of placental membranes (HP:0011409)3.68214017
24Myokymia (HP:0002411)3.61782858
25Septo-optic dysplasia (HP:0100842)3.44042968
26Atelectasis (HP:0100750)3.42208997
27Short tibia (HP:0005736)3.37793431
28Duplicated collecting system (HP:0000081)3.26634867
29Loss of speech (HP:0002371)3.13366678
30Apathy (HP:0000741)3.09587724
31Shawl scrotum (HP:0000049)3.07905177
32Absent radius (HP:0003974)3.04499066
33Degeneration of anterior horn cells (HP:0002398)3.03036759
34Abnormality of the anterior horn cell (HP:0006802)3.03036759
35Aplasia/Hypoplasia of the tibia (HP:0005772)3.02333546
36Absent septum pellucidum (HP:0001331)2.98839902
37Facial hemangioma (HP:0000329)2.98755689
38Diminished motivation (HP:0000745)2.97949418
39Hypoplasia of the fovea (HP:0007750)2.97080666
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.97080666
41Absent forearm bone (HP:0003953)2.96461290
42Aplasia involving forearm bones (HP:0009822)2.96461290
43Papillary thyroid carcinoma (HP:0002895)2.96459783
44Nonprogressive disorder (HP:0003680)2.94915310
45Patellar aplasia (HP:0006443)2.93488817
46Abnormal spermatogenesis (HP:0008669)2.93057058
47Secondary amenorrhea (HP:0000869)2.91539635
48Abnormality of the fovea (HP:0000493)2.90506300
49Azoospermia (HP:0000027)2.87800356
50* Premature ovarian failure (HP:0008209)2.85737657
51Aplasia/Hypoplasia of the breasts (HP:0010311)2.84787612
52Breast aplasia (HP:0100783)2.82414296
53Urethral obstruction (HP:0000796)2.81711885
54Abnormality of the renal collecting system (HP:0004742)2.77774859
55Birth length less than 3rd percentile (HP:0003561)2.75042357
56Hypogonadotrophic hypogonadism (HP:0000044)2.69918554
57Spinal muscular atrophy (HP:0007269)2.69285050
58Hypokinesia (HP:0002375)2.68437097
59Hypobetalipoproteinemia (HP:0003563)2.67390573
60Carpal bone hypoplasia (HP:0001498)2.66743952
61Aplasia of the musculature (HP:0100854)2.66674231
62Anophthalmia (HP:0000528)2.66391583
63Conjunctival telangiectasia (HP:0000524)2.64814423
64Abnormality of the septum pellucidum (HP:0007375)2.63909570
65Aplasia/Hypoplasia of the patella (HP:0006498)2.63292477
66Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.59151350
67Anhidrosis (HP:0000970)2.58069949
68Sclerocornea (HP:0000647)2.57124480
69Flat capital femoral epiphysis (HP:0003370)2.56894456
70Hypergonadotropic hypogonadism (HP:0000815)2.55544673
71Truncal obesity (HP:0001956)2.52978054
72Muscle stiffness (HP:0003552)2.52861913
73Skin pits (HP:0100276)2.47142232
74Global brain atrophy (HP:0002283)2.46177899
75Absent hand (HP:0004050)2.43676408
76Thyroid carcinoma (HP:0002890)2.42490424
77Fair hair (HP:0002286)2.39099316
78Congenital sensorineural hearing impairment (HP:0008527)2.37600870
79Colon cancer (HP:0003003)2.36687566
80Sensory axonal neuropathy (HP:0003390)2.36652119
81Rhabdomyosarcoma (HP:0002859)2.36503985
82Popliteal pterygium (HP:0009756)2.35339879
83Maternal diabetes (HP:0009800)2.34332678
84Cystic hygroma (HP:0000476)2.33402425
85Metaphyseal irregularity (HP:0003025)2.32731551
86Wrist flexion contracture (HP:0001239)2.31461527
87Horseshoe kidney (HP:0000085)2.29839110
88Bundle branch block (HP:0011710)2.29323818
89Enlarged penis (HP:0000040)2.28588008
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28479004
91Deep venous thrombosis (HP:0002625)2.25739400
92Abnormality of the anterior chamber (HP:0000593)2.25108373
93Lower limb hyperreflexia (HP:0002395)2.23309870
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.21933555
95Dysphonia (HP:0001618)2.20073956
96Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.18556443
97Neurofibrillary tangles (HP:0002185)2.17909384
98Type 2 muscle fiber atrophy (HP:0003554)2.17685412
99Spinal cord compression (HP:0002176)2.16749824
100Microglossia (HP:0000171)2.16741835
101Aplasia/Hypoplasia involving the musculature (HP:0001460)2.16672548
102Proximal tubulopathy (HP:0000114)2.16204449
103Macrocytic anemia (HP:0001972)2.15718765
104Anterior segment dysgenesis (HP:0007700)2.15653766
105Generalized aminoaciduria (HP:0002909)2.15166553
106Muscle fiber atrophy (HP:0100295)2.15050226
107Aplasia/Hypoplasia of the macula (HP:0008059)2.14884766
108Abnormal ciliary motility (HP:0012262)2.13256801
109Obstructive sleep apnea (HP:0002870)2.13216140
110Delayed puberty (HP:0000823)2.10974257
111Supernumerary spleens (HP:0009799)2.08093016
112Abnormality of calcium-phosphate metabolism (HP:0100530)2.07357183
113Abnormality of chromosome segregation (HP:0002916)2.04603971
114Pulmonary fibrosis (HP:0002206)2.04181283
115Dysdiadochokinesis (HP:0002075)2.03929190
116Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03555464
117Striae distensae (HP:0001065)2.03326290
118Papilledema (HP:0001085)2.03252119
119Multiple enchondromatosis (HP:0005701)2.01461961
120Rhinitis (HP:0012384)2.01452197
121Abnormal sex determination (HP:0012244)2.01358035
122Sex reversal (HP:0012245)2.01358035
123Anosmia (HP:0000458)2.00198533
124Adrenal hypoplasia (HP:0000835)1.99996698
125Pallor (HP:0000980)1.99478265
126Cholecystitis (HP:0001082)1.98912988
127Abnormal gallbladder physiology (HP:0012438)1.98912988
128Respiratory difficulties (HP:0002880)1.98795338
129Capillary hemangiomas (HP:0005306)1.97293225
130EMG: neuropathic changes (HP:0003445)1.97190732
131Increased intramyocellular lipid droplets (HP:0012240)1.96876056
132Hydroureter (HP:0000072)1.95539115
133Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94405291
134Supranuclear gaze palsy (HP:0000605)1.90732057
135Abnormality of chromosome stability (HP:0003220)1.90089036
136Preauricular pit (HP:0004467)1.90013565
137Periauricular skin pits (HP:0100277)1.90013565
138Oral leukoplakia (HP:0002745)1.89781533
139Decreased muscle mass (HP:0003199)1.88940431
140Abnormality of reticulocytes (HP:0004312)1.88761720
141Short thumb (HP:0009778)1.88745655
142Insulin-resistant diabetes mellitus (HP:0000831)1.87400850
143Primary amenorrhea (HP:0000786)1.87338675
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.87073917
145Cleft eyelid (HP:0000625)1.84167509
146Intrahepatic cholestasis (HP:0001406)1.84061958
147Stillbirth (HP:0003826)1.83343995
148Duplication of thumb phalanx (HP:0009942)1.83321522
149Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82375884
150Abnormality of the proximal phalanges of the hand (HP:0009834)1.82306667
151Male pseudohermaphroditism (HP:0000037)1.81944544
152Thin ribs (HP:0000883)1.81402207
153Cranial hyperostosis (HP:0004437)1.81034453
154Abnormality of pyrimidine metabolism (HP:0004353)1.80980654
155Limb hypertonia (HP:0002509)1.80149696
156Sandal gap (HP:0001852)1.79239709
157Increased hepatocellular lipid droplets (HP:0006565)1.78643324
158Abnormal lung lobation (HP:0002101)1.77965287
159Absent thumb (HP:0009777)1.76510719
160Meckel diverticulum (HP:0002245)1.75720022
161Hip contracture (HP:0003273)1.75548593
162Oligodactyly (HP:0012165)1.74662396
163Exertional dyspnea (HP:0002875)1.74534885
164Hypohidrosis (HP:0000966)1.73981497
165Increased circulating renin level (HP:0000848)1.73717980
166Nephroblastoma (Wilms tumor) (HP:0002667)1.72832101
167Abnormality of the preputium (HP:0100587)1.72746314
168Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72502797
169Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72502797
170Small intestinal stenosis (HP:0012848)1.72109990
171Duodenal stenosis (HP:0100867)1.72109990
172Abnormal respiratory motile cilium physiology (HP:0012261)1.70978071
173Facial cleft (HP:0002006)1.70934963
174Ankle contracture (HP:0006466)1.70120395
175Depressed nasal tip (HP:0000437)1.68401275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.40159723
2BRAF3.35330203
3LATS23.33623966
4TTK3.25900463
5ERBB43.22531209
6MOS2.97475010
7LATS12.96371405
8TAOK32.89171815
9BMPR22.88456929
10CDK82.70494877
11NEK62.66509088
12PRKD32.59327122
13KSR22.53862414
14CDK122.48046664
15MET2.37487193
16STK38L2.23630357
17MAP3K92.16849247
18MAPKAPK32.12924724
19MELK2.11874994
20DYRK22.09875676
21CDC72.08228154
22CHEK21.98888200
23RPS6KB21.97292957
24AKT31.96679028
25MAP3K41.92299084
26NEK21.79708154
27TRIM281.71379759
28TNIK1.59502125
29PLK11.59156842
30ACVR1B1.54912492
31PLK41.52392075
32ZAK1.43842878
33EIF2AK31.43485260
34AURKA1.40095084
35NTRK21.38649991
36MAP3K81.35478669
37BUB11.33504076
38MAP2K71.31378916
39PRKCI1.23534586
40MAPK131.20323993
41STK101.19681934
42WNK11.18044878
43AURKB1.14770575
44MAP2K41.14515467
45STK31.08037981
46CDK41.07805908
47STK161.04361811
48MUSK1.03445988
49VRK10.99437851
50PIM10.99354716
51STK390.98652687
52EEF2K0.95123521
53WEE10.94636254
54MAP2K20.91721366
55CDK90.87157298
56TLK10.86481428
57MAP3K20.86194158
58STK380.86139682
59ABL20.85666073
60CDK70.85416227
61MAP3K130.84910457
62TAOK10.83488140
63CSNK1G10.82280539
64BMPR1B0.81238512
65EIF2AK10.78712863
66PTK20.78169501
67DYRK30.75109806
68NEK10.75039568
69CSNK1G30.74885364
70SRPK10.74140850
71CSNK1G20.71450208
72NTRK30.71293046
73TESK20.68872362
74ATM0.67335200
75CHEK10.66816519
76KSR10.64674961
77NUAK10.63864310
78TGFBR10.62345280
79MARK30.62211759
80CAMK1D0.59834703
81TYRO30.59821264
82RET0.59471775
83STK40.58809499
84PKN10.58497552
85TNK20.57617594
86CDK20.56553891
87CSNK1A1L0.56043868
88TIE10.55352553
89CAMK1G0.55200225
90PRKD20.55091546
91BRD40.55004761
92PLK30.54867493
93PAK10.54311327
94MKNK20.54178874
95PDK30.53782549
96PDK40.53782549
97NEK90.52544258
98MTOR0.52526497
99RPS6KA40.51543366
100CDK10.50727616
101CSNK1E0.50627913
102MAP3K50.50108517
103ATR0.49218879
104OXSR10.46927962
105DMPK0.45749715
106CSNK1D0.45739601
107PLK20.44677880
108PRKG10.43571287
109LRRK20.43552579
110LIMK10.43499704
111PAK60.42467156
112STK240.41954839
113BRSK20.41065550
114BRSK10.40345437
115ARAF0.38350678
116RPS6KA10.36457183
117PRKCZ0.34409507
118RAF10.33935447
119CDK50.33088993
120CDK190.31699852
121RPS6KA50.31258415
122CDC42BPA0.31199912
123PBK0.30494932
124AKT10.29155435
125EPHA40.28030483
126AKT20.27931014
127MST40.25460589
128MAPK10.24974852
129BCKDK0.24896541
130CAMK2A0.23768009
131MAPK110.23617949
132NME10.23279716
133CAMK10.21937473
134PRKACB0.21815175
135PDK20.21407926
136PRKACA0.21049309
137TRPM70.20442721
138GSK3B0.19870734
139PDK10.19291973
140TRIB30.19289650
141CAMK40.19111583
142PRKDC0.19037313
143CSNK2A20.18535381
144CDK30.18052037
145PDPK10.17511735
146EGFR0.16382967
147MAP2K10.16120416
148CHUK0.15563976

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.36153115
2RNA polymerase_Homo sapiens_hsa030203.97018363
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58615769
4DNA replication_Homo sapiens_hsa030303.18422612
5Ribosome_Homo sapiens_hsa030103.11550579
6Cell cycle_Homo sapiens_hsa041102.96599694
7RNA transport_Homo sapiens_hsa030132.83389674
8Non-homologous end-joining_Homo sapiens_hsa034502.67870648
9RNA degradation_Homo sapiens_hsa030182.62928624
10Ovarian steroidogenesis_Homo sapiens_hsa049132.48930396
11Vitamin B6 metabolism_Homo sapiens_hsa007502.45316933
12Homologous recombination_Homo sapiens_hsa034402.44853917
13Mismatch repair_Homo sapiens_hsa034302.44023838
14Caffeine metabolism_Homo sapiens_hsa002322.36589900
15Nucleotide excision repair_Homo sapiens_hsa034202.34767300
16Oocyte meiosis_Homo sapiens_hsa041142.33271990
17Fanconi anemia pathway_Homo sapiens_hsa034601.97859609
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.96541610
19Base excision repair_Homo sapiens_hsa034101.95936898
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.93089889
21Olfactory transduction_Homo sapiens_hsa047401.84526524
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.81350332
23Proteasome_Homo sapiens_hsa030501.76584632
24mRNA surveillance pathway_Homo sapiens_hsa030151.67159230
25Spliceosome_Homo sapiens_hsa030401.62331022
26Pyrimidine metabolism_Homo sapiens_hsa002401.61591188
27Dorso-ventral axis formation_Homo sapiens_hsa043201.59891490
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45867309
29Huntingtons disease_Homo sapiens_hsa050161.40335406
30p53 signaling pathway_Homo sapiens_hsa041151.32020774
31Linoleic acid metabolism_Homo sapiens_hsa005911.28364712
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24040649
33Purine metabolism_Homo sapiens_hsa002301.18605080
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17382884
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13785379
36Systemic lupus erythematosus_Homo sapiens_hsa053221.11066876
37Pancreatic cancer_Homo sapiens_hsa052121.09372871
38Phototransduction_Homo sapiens_hsa047441.08829760
39mTOR signaling pathway_Homo sapiens_hsa041501.07264456
40Bile secretion_Homo sapiens_hsa049761.07042915
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.04420479
42GnRH signaling pathway_Homo sapiens_hsa049120.98815303
43ABC transporters_Homo sapiens_hsa020100.98138327
44Ether lipid metabolism_Homo sapiens_hsa005650.97322434
45TGF-beta signaling pathway_Homo sapiens_hsa043500.94965777
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93519397
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90733181
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88624996
49Parkinsons disease_Homo sapiens_hsa050120.85106060
50GABAergic synapse_Homo sapiens_hsa047270.80549356
51Taste transduction_Homo sapiens_hsa047420.80098100
52Colorectal cancer_Homo sapiens_hsa052100.79938468
53Hippo signaling pathway_Homo sapiens_hsa043900.79037854
54Oxidative phosphorylation_Homo sapiens_hsa001900.78262300
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77758816
56Thyroid cancer_Homo sapiens_hsa052160.75901861
57Fatty acid elongation_Homo sapiens_hsa000620.74633106
58VEGF signaling pathway_Homo sapiens_hsa043700.74386530
59Regulation of autophagy_Homo sapiens_hsa041400.73188741
60MicroRNAs in cancer_Homo sapiens_hsa052060.72136052
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71684020
62Morphine addiction_Homo sapiens_hsa050320.70286440
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.69042360
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66876576
65Epstein-Barr virus infection_Homo sapiens_hsa051690.66429184
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65857426
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64745337
68Bladder cancer_Homo sapiens_hsa052190.62212378
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60936681
70Viral carcinogenesis_Homo sapiens_hsa052030.60825399
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59411320
72Serotonergic synapse_Homo sapiens_hsa047260.59036050
73Melanoma_Homo sapiens_hsa052180.58981466
74HTLV-I infection_Homo sapiens_hsa051660.58358553
75Long-term depression_Homo sapiens_hsa047300.57504049
76Circadian rhythm_Homo sapiens_hsa047100.56871359
77Renal cell carcinoma_Homo sapiens_hsa052110.56230270
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.55468054
79One carbon pool by folate_Homo sapiens_hsa006700.52950410
80Long-term potentiation_Homo sapiens_hsa047200.52947022
81Biosynthesis of amino acids_Homo sapiens_hsa012300.52520877
82Glycerolipid metabolism_Homo sapiens_hsa005610.48817265
83Steroid biosynthesis_Homo sapiens_hsa001000.48496555
84Adherens junction_Homo sapiens_hsa045200.48383278
85Shigellosis_Homo sapiens_hsa051310.48195799
86Synaptic vesicle cycle_Homo sapiens_hsa047210.43946496
87Ras signaling pathway_Homo sapiens_hsa040140.42232716
88Vitamin digestion and absorption_Homo sapiens_hsa049770.41818177
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40819379
90Choline metabolism in cancer_Homo sapiens_hsa052310.37637887
91Lysine degradation_Homo sapiens_hsa003100.36462262
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.35991570
93Arginine and proline metabolism_Homo sapiens_hsa003300.35505546
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35326319
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35151408
96Non-small cell lung cancer_Homo sapiens_hsa052230.34320960
97Alcoholism_Homo sapiens_hsa050340.34153126
98MAPK signaling pathway_Homo sapiens_hsa040100.34107295
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33624598
100Pyruvate metabolism_Homo sapiens_hsa006200.33459283
101HIF-1 signaling pathway_Homo sapiens_hsa040660.30236060
102FoxO signaling pathway_Homo sapiens_hsa040680.30067973
103Protein export_Homo sapiens_hsa030600.30024371
104Inositol phosphate metabolism_Homo sapiens_hsa005620.29693652
105Chronic myeloid leukemia_Homo sapiens_hsa052200.29068601
106Alzheimers disease_Homo sapiens_hsa050100.26511732
107Prolactin signaling pathway_Homo sapiens_hsa049170.26269190
108ErbB signaling pathway_Homo sapiens_hsa040120.25488324
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25241804
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25166740
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24303881
112Glioma_Homo sapiens_hsa052140.24287441
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23591828
114Protein digestion and absorption_Homo sapiens_hsa049740.23053101
115cAMP signaling pathway_Homo sapiens_hsa040240.22622490
116Small cell lung cancer_Homo sapiens_hsa052220.21878158
117Arginine biosynthesis_Homo sapiens_hsa002200.21778981
118Oxytocin signaling pathway_Homo sapiens_hsa049210.21765981
119Folate biosynthesis_Homo sapiens_hsa007900.21274884
120Cholinergic synapse_Homo sapiens_hsa047250.20835081
121Insulin secretion_Homo sapiens_hsa049110.16842427
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16819972
123Metabolic pathways_Homo sapiens_hsa011000.16272245
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16062756
125Gap junction_Homo sapiens_hsa045400.15988309
126Phagosome_Homo sapiens_hsa041450.15964814
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15848166
128Calcium signaling pathway_Homo sapiens_hsa040200.15489862
129Selenocompound metabolism_Homo sapiens_hsa004500.14578396
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13656731
131Wnt signaling pathway_Homo sapiens_hsa043100.13233670
132Nicotine addiction_Homo sapiens_hsa050330.12810173
133Endometrial cancer_Homo sapiens_hsa052130.11428857
134Herpes simplex infection_Homo sapiens_hsa051680.11161698
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10764171
136Circadian entrainment_Homo sapiens_hsa047130.10537518
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08106031
138Tight junction_Homo sapiens_hsa045300.07751993
139Notch signaling pathway_Homo sapiens_hsa043300.07376873
140Prostate cancer_Homo sapiens_hsa052150.06755161
141Hepatitis B_Homo sapiens_hsa051610.06401712
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.05896234

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »