FIGNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.56046272
2DNA strand elongation involved in DNA replication (GO:0006271)5.47675131
3DNA replication initiation (GO:0006270)5.31292601
4DNA strand elongation (GO:0022616)5.20893110
5telomere maintenance via semi-conservative replication (GO:0032201)5.12508716
6protein localization to kinetochore (GO:0034501)4.99439246
7telomere maintenance via recombination (GO:0000722)4.69680517
8DNA replication checkpoint (GO:0000076)4.67346272
9mitotic recombination (GO:0006312)4.63879866
10kinetochore organization (GO:0051383)4.52559356
11mitotic metaphase plate congression (GO:0007080)4.52406790
12CENP-A containing nucleosome assembly (GO:0034080)4.50114846
13chromatin remodeling at centromere (GO:0031055)4.48905381
14mitotic chromosome condensation (GO:0007076)4.41204029
15nuclear pore organization (GO:0006999)4.39191987
16DNA replication-dependent nucleosome organization (GO:0034723)4.35032870
17DNA replication-dependent nucleosome assembly (GO:0006335)4.35032870
18protein localization to chromosome, centromeric region (GO:0071459)4.31655688
19DNA ligation (GO:0006266)4.30944777
20nuclear pore complex assembly (GO:0051292)4.25661970
21DNA replication-independent nucleosome assembly (GO:0006336)4.16714086
22DNA replication-independent nucleosome organization (GO:0034724)4.16714086
23telomere maintenance via telomere lengthening (GO:0010833)4.15249202
24mitotic nuclear envelope disassembly (GO:0007077)4.11019903
25non-recombinational repair (GO:0000726)4.10320554
26double-strand break repair via nonhomologous end joining (GO:0006303)4.10320554
27metaphase plate congression (GO:0051310)4.08883911
28mitotic sister chromatid segregation (GO:0000070)4.08243725
29nucleotide-excision repair, DNA gap filling (GO:0006297)4.06777904
30attachment of spindle microtubules to kinetochore (GO:0008608)4.04621619
31IMP biosynthetic process (GO:0006188)3.92020650
32nucleobase biosynthetic process (GO:0046112)3.91489261
33sister chromatid segregation (GO:0000819)3.91187184
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.89402324
35kinetochore assembly (GO:0051382)3.85850218
36histone exchange (GO:0043486)3.84031366
37establishment of chromosome localization (GO:0051303)3.81324464
38membrane disassembly (GO:0030397)3.79620385
39nuclear envelope disassembly (GO:0051081)3.79620385
40meiotic chromosome segregation (GO:0045132)3.78090697
41synapsis (GO:0007129)3.72831394
42regulation of mitotic spindle organization (GO:0060236)3.70732878
43replication fork processing (GO:0031297)3.68538048
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.66140335
45purine nucleobase biosynthetic process (GO:0009113)3.65327582
46DNA geometric change (GO:0032392)3.64891549
47DNA duplex unwinding (GO:0032508)3.63681711
48folic acid-containing compound biosynthetic process (GO:0009396)3.57623730
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.56760529
50ribosomal small subunit assembly (GO:0000028)3.55118259
51regulation of DNA endoreduplication (GO:0032875)3.54911697
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.54052663
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.54052663
54mitotic sister chromatid cohesion (GO:0007064)3.49744938
55establishment of viral latency (GO:0019043)3.45648154
56regulation of sister chromatid cohesion (GO:0007063)3.43162901
57IMP metabolic process (GO:0046040)3.42657861
58regulation of centrosome duplication (GO:0010824)3.41924004
59maturation of SSU-rRNA (GO:0030490)3.39957016
60formation of translation preinitiation complex (GO:0001731)3.39868149
61pore complex assembly (GO:0046931)3.38927567
62regulation of centrosome cycle (GO:0046605)3.38826307
63positive regulation of chromosome segregation (GO:0051984)3.38808615
64chromatin assembly or disassembly (GO:0006333)3.38417391
65mismatch repair (GO:0006298)3.38375258
66telomere maintenance (GO:0000723)3.37958182
67regulation of spindle organization (GO:0090224)3.36974417
68telomere organization (GO:0032200)3.36545681
69spindle checkpoint (GO:0031577)3.33257581
70regulation of chromosome segregation (GO:0051983)3.31580289
71sister chromatid cohesion (GO:0007062)3.26067511
72DNA conformation change (GO:0071103)3.24884870
73negative regulation of chromosome segregation (GO:0051985)3.24703884
74DNA topological change (GO:0006265)3.24495736
75spindle assembly checkpoint (GO:0071173)3.23676521
76DNA double-strand break processing (GO:0000729)3.23578810
77negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23066165
78negative regulation of sister chromatid segregation (GO:0033046)3.23066165
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.23066165
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23066165
81resolution of meiotic recombination intermediates (GO:0000712)3.22722927
82protein K6-linked ubiquitination (GO:0085020)3.22533445
83chromosome segregation (GO:0007059)3.22381708
84regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21938765
85translesion synthesis (GO:0019985)3.19862835
86protein localization to chromosome (GO:0034502)3.18567810
87regulation of mitotic spindle checkpoint (GO:1903504)3.17222880
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17222880
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.16950804
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15662874
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14911265
92postreplication repair (GO:0006301)3.13829566
93mitotic spindle assembly checkpoint (GO:0007094)3.13139162
94regulation of centriole replication (GO:0046599)3.13025456
95regulation of histone H3-K9 methylation (GO:0051570)3.12864833
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12805680
97ATP-dependent chromatin remodeling (GO:0043044)3.10554280
98chromosome condensation (GO:0030261)3.10518783
99DNA catabolic process, exonucleolytic (GO:0000738)3.09253741
100mitotic spindle checkpoint (GO:0071174)3.08894706
101negative regulation of DNA recombination (GO:0045910)3.08774701
102viral mRNA export from host cell nucleus (GO:0046784)3.08385502
103regulation of mitotic sister chromatid separation (GO:0010965)3.03891431
104regulation of mitotic sister chromatid segregation (GO:0033047)3.03891431
105regulation of sister chromatid segregation (GO:0033045)3.03891431
106DNA packaging (GO:0006323)3.03534061
107mitotic cell cycle (GO:0000278)3.01629370
108ribosome biogenesis (GO:0042254)3.01407975
109positive regulation of histone H3-K4 methylation (GO:0051571)3.01194047
110transcription-coupled nucleotide-excision repair (GO:0006283)3.01152004
111* regulation of double-strand break repair via homologous recombination (GO:0010569)3.00978914
112DNA replication (GO:0006260)2.98284502
113ribosome assembly (GO:0042255)2.98246457
114regulation of helicase activity (GO:0051095)2.98082945
115base-excision repair (GO:0006284)2.97484024
116positive regulation of mitotic sister chromatid separation (GO:1901970)2.97376763
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97376763
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97376763
119establishment of integrated proviral latency (GO:0075713)2.96036895
120cell cycle G1/S phase transition (GO:0044843)2.94897263
121G1/S transition of mitotic cell cycle (GO:0000082)2.94897263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.09946972
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.49428451
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.98640362
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.63018697
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36385830
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98748830
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76194138
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70784355
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.65101290
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57143702
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44755243
12AR_21909140_ChIP-Seq_LNCAP_Human2.43990099
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37104689
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.36221648
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.35933776
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33837784
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.30537785
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30169785
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19977817
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19615343
21XRN2_22483619_ChIP-Seq_HELA_Human2.13657937
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13143428
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09374304
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.08244392
25VDR_23849224_ChIP-Seq_CD4+_Human2.06545610
26E2F7_22180533_ChIP-Seq_HELA_Human11.2081250
27FOXP3_21729870_ChIP-Seq_TREG_Human1.86237213
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84562596
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84434873
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81859455
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81723036
32DCP1A_22483619_ChIP-Seq_HELA_Human1.81083467
33TTF2_22483619_ChIP-Seq_HELA_Human1.70711991
34* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70066873
35ELK1_19687146_ChIP-ChIP_HELA_Human1.67873225
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65539667
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63159030
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61834349
39* GABP_19822575_ChIP-Seq_HepG2_Human1.61397786
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58744938
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57785642
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55490059
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52780942
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51799719
45CIITA_25753668_ChIP-Seq_RAJI_Human1.51623525
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49370636
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46400513
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44885801
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44394446
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40114312
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40092271
52MYC_22102868_ChIP-Seq_BL_Human1.37230931
53EWS_26573619_Chip-Seq_HEK293_Human1.35936921
54KDM5A_27292631_Chip-Seq_BREAST_Human1.34504219
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34382542
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28800499
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28720877
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.27443953
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.25414077
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23425512
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22720217
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22116934
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.21591158
64FUS_26573619_Chip-Seq_HEK293_Human1.20588678
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20444239
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19768249
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19621593
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18941700
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15587786
70TFEB_21752829_ChIP-Seq_HELA_Human1.06826933
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05172479
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05048547
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.04193943
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04141055
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04135900
76* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99602213
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98215822
78POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98103945
79MYC_18940864_ChIP-ChIP_HL60_Human0.97401707
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95884673
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94269532
82* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92337156
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91219734
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90153260
85ZNF274_21170338_ChIP-Seq_K562_Hela0.89794450
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88849069
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88824945
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.85899876
89SPI1_23547873_ChIP-Seq_NB4_Human0.85110636
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82678278
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82123963
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.81740676
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.81023723
94* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80895248
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79518758
96IRF1_19129219_ChIP-ChIP_H3396_Human0.78789759
97VDR_21846776_ChIP-Seq_THP-1_Human0.77485030
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77242057
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77129364
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.76440283
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.76233037
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75323625
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74740500
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74633691
105IGF1R_20145208_ChIP-Seq_DFB_Human0.74122103
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71053637
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70668125
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70012724
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69810008
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.67732007
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66748256
112CHD1_26751641_Chip-Seq_LNCaP_Human0.65802970
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.64546196
114PKCTHETA_26484144_Chip-Seq_BREAST_Human0.64204265
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.64062626
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.63684319
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.63466480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.40611188
2MP0003693_abnormal_embryo_hatching5.14473402
3MP0008057_abnormal_DNA_replication4.80358103
4MP0003111_abnormal_nucleus_morphology4.77277113
5MP0003077_abnormal_cell_cycle4.19764890
6MP0004957_abnormal_blastocyst_morpholog4.14280999
7MP0008058_abnormal_DNA_repair3.60715321
8MP0008007_abnormal_cellular_replicative2.94930237
9MP0008932_abnormal_embryonic_tissue2.68504451
10MP0002396_abnormal_hematopoietic_system2.64652865
11MP0003123_paternal_imprinting2.50180089
12MP0008877_abnormal_DNA_methylation2.45144422
13MP0000350_abnormal_cell_proliferation2.27577163
14MP0001730_embryonic_growth_arrest2.27217204
15MP0010307_abnormal_tumor_latency2.19365493
16MP0010352_gastrointestinal_tract_polyps2.07182762
17MP0003786_premature_aging1.98203823
18MP0000490_abnormal_crypts_of1.73746743
19MP0005380_embryogenesis_phenotype1.69487902
20MP0001672_abnormal_embryogenesis/_devel1.69487902
21MP0003121_genomic_imprinting1.69006415
22MP0001697_abnormal_embryo_size1.67666813
23MP0000383_abnormal_hair_follicle1.59695758
24MP0002009_preneoplasia1.57848968
25MP0004808_abnormal_hematopoietic_stem1.51843926
26MP0003984_embryonic_growth_retardation1.51341681
27MP0002080_prenatal_lethality1.50103598
28MP0000313_abnormal_cell_death1.47947217
29MP0002088_abnormal_embryonic_growth/wei1.47601341
30MP0000427_abnormal_hair_cycle1.47529056
31MP0002085_abnormal_embryonic_tissue1.45271142
32MP0002019_abnormal_tumor_incidence1.42225346
33MP0002210_abnormal_sex_determination1.40920494
34MP0010678_abnormal_skin_adnexa1.40800730
35MP0004197_abnormal_fetal_growth/weight/1.38084340
36MP0002084_abnormal_developmental_patter1.34791207
37MP0002086_abnormal_extraembryonic_tissu1.34689034
38MP0003567_abnormal_fetal_cardiomyocyte1.33418941
39MP0008789_abnormal_olfactory_epithelium1.29417811
40MP0002234_abnormal_pharynx_morphology1.29247361
41MP0005076_abnormal_cell_differentiation1.28341300
42MP0001293_anophthalmia1.27205112
43MP0004233_abnormal_muscle_weight1.26526712
44MP0003718_maternal_effect1.25186069
45MP0002822_catalepsy1.22977945
46MP0003890_abnormal_embryonic-extraembry1.20784024
47MP0006054_spinal_hemorrhage1.20646697
48MP0003315_abnormal_perineum_morphology1.20133678
49MP0001145_abnormal_male_reproductive1.19958307
50MP0005397_hematopoietic_system_phenotyp1.18799628
51MP0001545_abnormal_hematopoietic_system1.18799628
52MP0004147_increased_porphyrin_level1.18007403
53MP0000647_abnormal_sebaceous_gland1.17522535
54MP0005394_taste/olfaction_phenotype1.16983853
55MP0005499_abnormal_olfactory_system1.16983853
56MP0001929_abnormal_gametogenesis1.13776728
57MP0000703_abnormal_thymus_morphology1.11113112
58MP0010030_abnormal_orbit_morphology1.10221008
59MP0002398_abnormal_bone_marrow1.10032919
60MP0006035_abnormal_mitochondrial_morpho1.07722059
61MP0003763_abnormal_thymus_physiology1.07142319
62MP0009333_abnormal_splenocyte_physiolog1.06997260
63MP0002877_abnormal_melanocyte_morpholog1.03388925
64MP0001529_abnormal_vocalization1.03035627
65MP0000653_abnormal_sex_gland1.01793019
66MP0006072_abnormal_retinal_apoptosis1.01619321
67MP0002160_abnormal_reproductive_system1.01473329
68MP0002722_abnormal_immune_system0.99573536
69MP0002697_abnormal_eye_size0.97519402
70MP0000689_abnormal_spleen_morphology0.96503483
71MP0000579_abnormal_nail_morphology0.95272827
72MP0006292_abnormal_olfactory_placode0.94833365
73MP0002233_abnormal_nose_morphology0.93842313
74MP0000372_irregular_coat_pigmentation0.92857520
75MP0001119_abnormal_female_reproductive0.90285857
76MP0003806_abnormal_nucleotide_metabolis0.88176817
77MP0002429_abnormal_blood_cell0.83974980
78MP0003755_abnormal_palate_morphology0.83720188
79MP0005171_absent_coat_pigmentation0.83593307
80MP0005389_reproductive_system_phenotype0.83217427
81MP0005395_other_phenotype0.81681664
82MP0009053_abnormal_anal_canal0.80056731
83MP0000537_abnormal_urethra_morphology0.78463720
84MP0005384_cellular_phenotype0.77912023
85MP0003935_abnormal_craniofacial_develop0.77581176
86MP0009672_abnormal_birth_weight0.77231794
87MP0003937_abnormal_limbs/digits/tail_de0.76064739
88MP0001727_abnormal_embryo_implantation0.75426756
89MP0001177_atelectasis0.74856358
90MP0000858_altered_metastatic_potential0.74383153
91MP0002098_abnormal_vibrissa_morphology0.73977933
92MP0003699_abnormal_female_reproductive0.73854220
93MP0002132_abnormal_respiratory_system0.73807379
94MP0001346_abnormal_lacrimal_gland0.73298953
95MP0002095_abnormal_skin_pigmentation0.72648457
96MP0004133_heterotaxia0.71811014
97MP0002111_abnormal_tail_morphology0.71787759
98MP0005621_abnormal_cell_physiology0.71109942
99MP0000358_abnormal_cell_content/0.71010951
100MP0003861_abnormal_nervous_system0.70952193
101MP0010234_abnormal_vibrissa_follicle0.70946047
102MP0003941_abnormal_skin_development0.70931818
103MP0000377_abnormal_hair_follicle0.69508983
104MP0005391_vision/eye_phenotype0.69419807
105MP0001915_intracranial_hemorrhage0.69417941
106MP0005187_abnormal_penis_morphology0.68404503
107MP0009703_decreased_birth_body0.68174067
108MP0002938_white_spotting0.67308554
109MP0000716_abnormal_immune_system0.66931115
110MP0005174_abnormal_tail_pigmentation0.65474744
111MP0000566_synostosis0.65266475
112MP0003119_abnormal_digestive_system0.64062436
113MP0009250_abnormal_appendicular_skeleto0.63758204
114MP0002075_abnormal_coat/hair_pigmentati0.63748451
115MP0009697_abnormal_copulation0.63416907
116MP0003950_abnormal_plasma_membrane0.63340699
117MP0001286_abnormal_eye_development0.63052114
118MP0003698_abnormal_male_reproductive0.62850383
119MP0002092_abnormal_eye_morphology0.62772323
120MP0005253_abnormal_eye_physiology0.62520567
121MP0003656_abnormal_erythrocyte_physiolo0.62350860
122MP0009278_abnormal_bone_marrow0.61773844
123MP0000569_abnormal_digit_pigmentation0.61702339
124MP0003186_abnormal_redox_activity0.61395740
125MP0003221_abnormal_cardiomyocyte_apopto0.61130768
126MP0005023_abnormal_wound_healing0.58691308
127MP0001835_abnormal_antigen_presentation0.58625279
128MP0003566_abnormal_cell_adhesion0.57719011
129MP0001919_abnormal_reproductive_system0.56540079
130MP0004264_abnormal_extraembryonic_tissu0.55978672
131MP0000477_abnormal_intestine_morphology0.54793931
132MP0001800_abnormal_humoral_immune0.53275009
133MP0001853_heart_inflammation0.53004158
134MP0003943_abnormal_hepatobiliary_system0.52854059
135MP0001186_pigmentation_phenotype0.51388077
136MP0000015_abnormal_ear_pigmentation0.51357254
137MP0002161_abnormal_fertility/fecundity0.51187513
138MP0002102_abnormal_ear_morphology0.50631166

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.27730167
2Birth length less than 3rd percentile (HP:0003561)5.05482956
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.02097297
4Abnormality of chromosome stability (HP:0003220)4.04328457
5Reticulocytopenia (HP:0001896)3.99267831
6Meckel diverticulum (HP:0002245)3.73791025
7Abnormality of the preputium (HP:0100587)3.67531356
8Abnormality of the ileum (HP:0001549)3.60472053
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.53634939
10Colon cancer (HP:0003003)3.51485631
11Medulloblastoma (HP:0002885)3.45434411
12Breast hypoplasia (HP:0003187)3.36218360
13Selective tooth agenesis (HP:0001592)3.32056555
14Duodenal stenosis (HP:0100867)3.23812564
15Small intestinal stenosis (HP:0012848)3.23812564
16Ependymoma (HP:0002888)3.20873927
17Patellar aplasia (HP:0006443)3.19868792
18Agnosia (HP:0010524)3.19431352
19Abnormality of cells of the erythroid lineage (HP:0012130)3.16487724
20Oral leukoplakia (HP:0002745)3.13002770
21Abnormal number of erythroid precursors (HP:0012131)3.11897594
22Myelodysplasia (HP:0002863)3.04664953
23Aplasia/Hypoplasia of the patella (HP:0006498)2.96256567
24Impulsivity (HP:0100710)2.93928496
25Cortical dysplasia (HP:0002539)2.93576476
2611 pairs of ribs (HP:0000878)2.91402256
27Degeneration of anterior horn cells (HP:0002398)2.89404939
28Abnormality of the anterior horn cell (HP:0006802)2.89404939
29Ectopic kidney (HP:0000086)2.87456253
30Absent thumb (HP:0009777)2.85049959
31Duplicated collecting system (HP:0000081)2.74759649
32Abnormal lung lobation (HP:0002101)2.72788157
33Bone marrow hypocellularity (HP:0005528)2.69072502
34Sloping forehead (HP:0000340)2.68808401
35Volvulus (HP:0002580)2.68248829
36Absent radius (HP:0003974)2.65021834
37Abnormality of the renal collecting system (HP:0004742)2.63159789
38Nephroblastoma (Wilms tumor) (HP:0002667)2.62891290
39Rhabdomyosarcoma (HP:0002859)2.62021965
40Abnormality of the duodenum (HP:0002246)2.61835050
41Aplastic anemia (HP:0001915)2.56214386
42Increased nuchal translucency (HP:0010880)2.55884512
43Microvesicular hepatic steatosis (HP:0001414)2.52302716
44Abnormality of the carotid arteries (HP:0005344)2.50068261
45Embryonal renal neoplasm (HP:0011794)2.47590148
46Aplasia involving forearm bones (HP:0009822)2.44298662
47Absent forearm bone (HP:0003953)2.44298662
48Supernumerary spleens (HP:0009799)2.43038692
49Abnormal number of incisors (HP:0011064)2.42157601
50Carpal bone hypoplasia (HP:0001498)2.41971538
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.38188797
52Premature graying of hair (HP:0002216)2.35873044
53Clubbing of toes (HP:0100760)2.33603290
54Rough bone trabeculation (HP:0100670)2.31885903
55Neoplasm of the pancreas (HP:0002894)2.31296154
56Deep philtrum (HP:0002002)2.30819067
57Abnormality of glycolysis (HP:0004366)2.29717295
58Abnormality of the labia minora (HP:0012880)2.28177814
59Proximal placement of thumb (HP:0009623)2.24473346
60Tracheoesophageal fistula (HP:0002575)2.23037364
61Deviation of the thumb (HP:0009603)2.22094102
62Choanal atresia (HP:0000453)2.21886051
63Basal cell carcinoma (HP:0002671)2.21457418
64Abnormality of cochlea (HP:0000375)2.21157013
65Cafe-au-lait spot (HP:0000957)2.20742798
66Arteriovenous malformation (HP:0100026)2.19129048
67Horseshoe kidney (HP:0000085)2.16864202
68Atresia of the external auditory canal (HP:0000413)2.15609133
69Triphalangeal thumb (HP:0001199)2.15096273
70Abnormality of DNA repair (HP:0003254)2.15083487
71Abnormality of the heme biosynthetic pathway (HP:0010472)2.14870434
72Multiple enchondromatosis (HP:0005701)2.14700564
73Pallor (HP:0000980)2.14041266
74Amaurosis fugax (HP:0100576)2.12992564
75Short thumb (HP:0009778)2.12911568
76Missing ribs (HP:0000921)2.12322233
77Abnormal protein glycosylation (HP:0012346)2.06713796
78Abnormal glycosylation (HP:0012345)2.06713796
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06713796
80Abnormal protein N-linked glycosylation (HP:0012347)2.06713796
81Lymphoma (HP:0002665)2.04265945
82Glioma (HP:0009733)2.02717109
83High pitched voice (HP:0001620)2.02460817
84Abnormality of the astrocytes (HP:0100707)2.01970033
85Astrocytoma (HP:0009592)2.01970033
86Neoplasm of the colon (HP:0100273)2.01797179
87Squamous cell carcinoma (HP:0002860)2.01773640
88Cellular immunodeficiency (HP:0005374)1.99335636
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.96918195
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96700799
91Abnormality of chromosome segregation (HP:0002916)1.95488083
92Macrocytic anemia (HP:0001972)1.95325995
93Facial cleft (HP:0002006)1.94829062
94Increased serum pyruvate (HP:0003542)1.93834309
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93599171
96Short 4th metacarpal (HP:0010044)1.93599171
97Gonadotropin excess (HP:0000837)1.92927134
98Type I transferrin isoform profile (HP:0003642)1.91671398
99Slender long bone (HP:0003100)1.87924998
100Microretrognathia (HP:0000308)1.87017133
101Oligodactyly (HP:0012165)1.85252212
102Neoplasm of striated muscle (HP:0009728)1.85099005
103Oligodactyly (hands) (HP:0001180)1.84776166
104Ovarian neoplasm (HP:0100615)1.84004696
105Abnormality of reticulocytes (HP:0004312)1.83077070
106Neoplasm of the oral cavity (HP:0100649)1.82722411
107Prominent nose (HP:0000448)1.81974372
108Abnormality of pyrimidine metabolism (HP:0004353)1.80609489
109Methylmalonic acidemia (HP:0002912)1.80229918
110Thrombocytosis (HP:0001894)1.78143596
111Abnormal gallbladder physiology (HP:0012438)1.77922544
112Cholecystitis (HP:0001082)1.77922544
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77867122
114Absent epiphyses (HP:0010577)1.77867122
115High anterior hairline (HP:0009890)1.77502213
116Secondary amenorrhea (HP:0000869)1.76755644
117Overlapping toe (HP:0001845)1.75341278
118Cerebral hypomyelination (HP:0006808)1.74319979
119Cleft eyelid (HP:0000625)1.72605089
120Astigmatism (HP:0000483)1.71707536
121Pancytopenia (HP:0001876)1.71064153
122Facial hemangioma (HP:0000329)1.69784697
123Optic nerve coloboma (HP:0000588)1.68559870
124Abnormal trabecular bone morphology (HP:0100671)1.68044356
125Short middle phalanx of the 5th finger (HP:0004220)1.67594434
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66313500
127Morphological abnormality of the inner ear (HP:0011390)1.65776064
128Freckling (HP:0001480)1.64146962
129Acute myeloid leukemia (HP:0004808)1.62933944
130Embryonal neoplasm (HP:0002898)1.61629285
131Hypoplastic pelvis (HP:0008839)1.61321980
132Horizontal nystagmus (HP:0000666)1.58773348
133Neoplasm of the adrenal gland (HP:0100631)1.55102978
134Preaxial hand polydactyly (HP:0001177)1.51837426
135Shoulder girdle muscle weakness (HP:0003547)1.49067999
136Progressive external ophthalmoplegia (HP:0000590)1.48917365
137Pheochromocytoma (HP:0002666)1.46880795
138Median cleft lip (HP:0000161)1.46846220
139Partial agenesis of the corpus callosum (HP:0001338)1.46453270
140Abnormality of methionine metabolism (HP:0010901)1.46111921
141Aplasia/Hypoplasia of the earlobes (HP:0009906)1.44244501
142Premature ovarian failure (HP:0008209)1.44010492
143Papillary thyroid carcinoma (HP:0002895)1.43143269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.02101794
2WEE14.34235746
3BUB14.10468388
4EIF2AK13.24346859
5NEK22.96220190
6BRSK22.64346526
7TTK2.62699446
8SRPK12.60469468
9NEK12.46460408
10ACVR1B2.39788413
11PLK42.28821702
12PLK12.15234965
13ERBB42.07889386
14PDK22.06568732
15ATR2.01887226
16PASK1.99312929
17MKNK11.97124784
18CCNB11.96984678
19TSSK61.95632014
20VRK11.95230475
21AURKB1.85999381
22PLK31.82753449
23STK161.80048157
24BRSK11.74152971
25EIF2AK31.73113527
26CDK71.69155132
27TLK11.65375450
28TRIM281.62741492
29CHEK21.59529409
30STK101.53898872
31CDK121.50136598
32ZAK1.45417706
33RPS6KB21.42289088
34CDK41.40715916
35STK41.39213483
36TAF11.38836642
37MKNK21.38658596
38MAP3K81.35981963
39CHEK11.34126008
40DYRK31.33281872
41RPS6KA41.31359185
42NME21.30677183
43TGFBR11.27089076
44VRK21.25718028
45AURKA1.20891557
46SCYL21.20393052
47NUAK11.17292357
48TESK21.15922280
49MAP4K21.10428103
50EEF2K1.10308580
51ATM1.08644954
52MET1.00360924
53BMPR1B0.92484367
54FLT30.91763594
55PIM10.91566461
56EIF2AK20.90796667
57MELK0.89464892
58CDK20.89333562
59CLK10.87177925
60PBK0.83933000
61NEK60.82770778
62CDK90.80660145
63PLK20.79020017
64BCR0.78160729
65BRD40.78090532
66MST1R0.77679138
67STK30.76478754
68CDK60.75268235
69CDK10.74106115
70MAP3K100.70610843
71CDK80.68913977
72PAK40.68325281
73MAP4K10.67915781
74CSNK2A10.64990923
75TESK10.63697470
76CSNK2A20.62646315
77RAF10.61297517
78EPHA20.59354546
79NME10.56327696
80TEC0.53653368
81CSNK1G10.52815449
82PAK10.52114079
83RPS6KA50.51352187
84KSR10.50799547
85YES10.50361222
86ALK0.49668533
87CSNK1A1L0.49585184
88MAP3K40.49317344
89LRRK20.48612951
90CSNK1G30.48407601
91BTK0.46798281
92CDK30.46602975
93WNK30.45700224
94BRAF0.45494109
95MST40.45134292
96PKN20.44827670
97PDK30.44228076
98PDK40.44228076
99LATS10.42826061
100PRKDC0.41546591
101NEK90.39966122
102MAP2K70.39200697
103MAPK110.39003600
104STK38L0.37157105
105PRKCI0.36497765
106IRAK40.35031263
107MAPK130.32900813
108TRPM70.32063187
109STK390.31206566
110MAP2K30.30154025
111CDK180.30047025
112AKT20.29438359
113PIM20.29088350
114SMG10.28473852
115MAPK140.28441634
116CSNK1D0.27993844
117MARK30.27258850
118IRAK20.26447475
119CSF1R0.25970577
120PNCK0.25446714
121RPS6KB10.25121558
122LYN0.24173823
123KIT0.22042586
124AKT10.21006643
125ERBB30.20698684
126CSNK1E0.20624537
127JAK30.19596217
128KDR0.18972060
129RPS6KC10.17814276
130RPS6KL10.17814276
131RPS6KA60.17401842
132TXK0.16142961

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.67767500
2Mismatch repair_Homo sapiens_hsa034304.81974857
3Homologous recombination_Homo sapiens_hsa034403.50662219
4Base excision repair_Homo sapiens_hsa034103.41047532
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28404538
6Spliceosome_Homo sapiens_hsa030403.15283827
7Cell cycle_Homo sapiens_hsa041103.12387007
8Nucleotide excision repair_Homo sapiens_hsa034203.08326893
9RNA transport_Homo sapiens_hsa030132.97401496
10One carbon pool by folate_Homo sapiens_hsa006702.82544804
11Fanconi anemia pathway_Homo sapiens_hsa034602.77648055
12Ribosome_Homo sapiens_hsa030102.56851033
13RNA polymerase_Homo sapiens_hsa030202.56803062
14Proteasome_Homo sapiens_hsa030502.56630661
15Non-homologous end-joining_Homo sapiens_hsa034502.54315201
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45644179
17Pyrimidine metabolism_Homo sapiens_hsa002402.32367432
18RNA degradation_Homo sapiens_hsa030181.94987148
19Basal transcription factors_Homo sapiens_hsa030221.83651198
20mRNA surveillance pathway_Homo sapiens_hsa030151.76033315
21p53 signaling pathway_Homo sapiens_hsa041151.69699985
22Systemic lupus erythematosus_Homo sapiens_hsa053221.53084144
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50343882
24Propanoate metabolism_Homo sapiens_hsa006401.27545648
25Purine metabolism_Homo sapiens_hsa002301.25520471
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18633884
27Epstein-Barr virus infection_Homo sapiens_hsa051691.13612027
28Pyruvate metabolism_Homo sapiens_hsa006201.11852562
29Viral carcinogenesis_Homo sapiens_hsa052031.08723333
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08450178
31Steroid biosynthesis_Homo sapiens_hsa001001.08422063
32Herpes simplex infection_Homo sapiens_hsa051681.04660328
33Oocyte meiosis_Homo sapiens_hsa041141.02388268
34Antigen processing and presentation_Homo sapiens_hsa046121.01533762
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95318396
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92689579
37Fatty acid elongation_Homo sapiens_hsa000620.91444897
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89700505
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88589731
40HTLV-I infection_Homo sapiens_hsa051660.82732079
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77900966
42Pentose phosphate pathway_Homo sapiens_hsa000300.74202666
43Selenocompound metabolism_Homo sapiens_hsa004500.70096740
44Legionellosis_Homo sapiens_hsa051340.70023424
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69213979
46MicroRNAs in cancer_Homo sapiens_hsa052060.67793528
47Primary immunodeficiency_Homo sapiens_hsa053400.66563061
48Sulfur relay system_Homo sapiens_hsa041220.64539930
49Small cell lung cancer_Homo sapiens_hsa052220.62468547
50Biosynthesis of amino acids_Homo sapiens_hsa012300.62139367
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59959215
52Alcoholism_Homo sapiens_hsa050340.59183612
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.58199894
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57319777
55Vitamin B6 metabolism_Homo sapiens_hsa007500.55027509
56Measles_Homo sapiens_hsa051620.52572165
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52031296
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.51268340
59Protein export_Homo sapiens_hsa030600.49394249
60Folate biosynthesis_Homo sapiens_hsa007900.46460440
61Apoptosis_Homo sapiens_hsa042100.45816069
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44297374
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.43797100
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.43308728
65Thyroid cancer_Homo sapiens_hsa052160.42633881
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41628284
67Hepatitis B_Homo sapiens_hsa051610.41596171
68Glutathione metabolism_Homo sapiens_hsa004800.40678419
69Parkinsons disease_Homo sapiens_hsa050120.38963599
70Hedgehog signaling pathway_Homo sapiens_hsa043400.38280021
71N-Glycan biosynthesis_Homo sapiens_hsa005100.38094780
72TGF-beta signaling pathway_Homo sapiens_hsa043500.37575710
73Hematopoietic cell lineage_Homo sapiens_hsa046400.37261228
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34444233
75Colorectal cancer_Homo sapiens_hsa052100.34265507
76Influenza A_Homo sapiens_hsa051640.33616932
77Carbon metabolism_Homo sapiens_hsa012000.33595609
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32668907
79Basal cell carcinoma_Homo sapiens_hsa052170.31471913
80Huntingtons disease_Homo sapiens_hsa050160.31118875
81Viral myocarditis_Homo sapiens_hsa054160.30140175
82Hippo signaling pathway_Homo sapiens_hsa043900.30106308
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28856116
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28699930
85Melanoma_Homo sapiens_hsa052180.28263782
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27980383
87Chronic myeloid leukemia_Homo sapiens_hsa052200.26535487
88Circadian rhythm_Homo sapiens_hsa047100.26490363
89Notch signaling pathway_Homo sapiens_hsa043300.25771755
90Fatty acid metabolism_Homo sapiens_hsa012120.25215403
91Oxidative phosphorylation_Homo sapiens_hsa001900.25177153
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.24343658
93Shigellosis_Homo sapiens_hsa051310.24288520
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23501822
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23112130
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21912617
97Pathways in cancer_Homo sapiens_hsa052000.21516856
98HIF-1 signaling pathway_Homo sapiens_hsa040660.20227008
99Arginine and proline metabolism_Homo sapiens_hsa003300.19018176
100Renin-angiotensin system_Homo sapiens_hsa046140.18765873
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16852644
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16443080
103Wnt signaling pathway_Homo sapiens_hsa043100.16218951
104Nitrogen metabolism_Homo sapiens_hsa009100.16182438
105Adherens junction_Homo sapiens_hsa045200.15417987
106Prostate cancer_Homo sapiens_hsa052150.15222307
107Endometrial cancer_Homo sapiens_hsa052130.15207887
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14524804
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14423470
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.13642652
111Regulation of autophagy_Homo sapiens_hsa041400.13349540
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13263360
113Peroxisome_Homo sapiens_hsa041460.12469601
114Asthma_Homo sapiens_hsa053100.12459687
115Bladder cancer_Homo sapiens_hsa052190.12123391
116Lysine degradation_Homo sapiens_hsa003100.11455770
117Fructose and mannose metabolism_Homo sapiens_hsa000510.11396359
118Allograft rejection_Homo sapiens_hsa053300.10655290
119Leishmaniasis_Homo sapiens_hsa051400.10644499
120Arachidonic acid metabolism_Homo sapiens_hsa005900.10446482
121Galactose metabolism_Homo sapiens_hsa000520.10289204
122Metabolic pathways_Homo sapiens_hsa011000.10242142
123Pancreatic cancer_Homo sapiens_hsa052120.09999448
124Autoimmune thyroid disease_Homo sapiens_hsa053200.09017057
125Non-small cell lung cancer_Homo sapiens_hsa052230.08422241
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06622718
127Phototransduction_Homo sapiens_hsa047440.06203629
128Olfactory transduction_Homo sapiens_hsa047400.05216346

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