FIGNL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.82557491
2paraxial mesoderm development (GO:0048339)5.43694723
3regulation of gene silencing by miRNA (GO:0060964)5.09579901
4regulation of gene silencing by RNA (GO:0060966)5.09579901
5regulation of posttranscriptional gene silencing (GO:0060147)5.09579901
6convergent extension (GO:0060026)5.04587956
7protein-DNA complex disassembly (GO:0032986)4.52595752
8nucleosome disassembly (GO:0006337)4.52595752
9lung-associated mesenchyme development (GO:0060484)4.35315099
10mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.07155640
11establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)4.04946994
12Wnt signaling pathway, planar cell polarity pathway (GO:0060071)4.04553848
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.00220348
14L-phenylalanine metabolic process (GO:0006558)4.00220348
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.99380848
16L-phenylalanine catabolic process (GO:0006559)3.99380848
17regulation of establishment of planar polarity (GO:0090175)3.85353914
18midgut development (GO:0007494)3.83507906
19axon extension involved in axon guidance (GO:0048846)3.75568460
20neuron projection extension involved in neuron projection guidance (GO:1902284)3.75568460
21polarized epithelial cell differentiation (GO:0030859)3.73797113
22glyoxylate metabolic process (GO:0046487)3.73249828
23establishment or maintenance of bipolar cell polarity (GO:0061245)3.69975399
24establishment or maintenance of apical/basal cell polarity (GO:0035088)3.69975399
25G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.69456777
26non-canonical Wnt signaling pathway (GO:0035567)3.66354697
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.61652711
28mRNA stabilization (GO:0048255)3.58055145
29RNA stabilization (GO:0043489)3.58055145
30histone H3-K36 demethylation (GO:0070544)3.54174282
31glycine metabolic process (GO:0006544)3.52863273
32cell surface receptor signaling pathway involved in heart development (GO:0061311)3.51688958
33negative regulation of fibrinolysis (GO:0051918)3.51217381
34regulation of stem cell maintenance (GO:2000036)3.51072381
35aromatic amino acid family catabolic process (GO:0009074)3.50670412
36negative regulation of cell fate specification (GO:0009996)3.45471763
37regulation of NFAT protein import into nucleus (GO:0051532)3.44678308
38gap junction assembly (GO:0016264)3.44647978
39cell migration in hindbrain (GO:0021535)3.40208548
40lysine metabolic process (GO:0006553)3.38899094
41lysine catabolic process (GO:0006554)3.38899094
42plasma lipoprotein particle clearance (GO:0034381)3.38296269
43somatic stem cell division (GO:0048103)3.38208031
44kynurenine metabolic process (GO:0070189)3.38052364
45planar cell polarity pathway involved in neural tube closure (GO:0090179)3.35858401
46alpha-linolenic acid metabolic process (GO:0036109)3.35185970
47hippo signaling (GO:0035329)3.34420786
48low-density lipoprotein particle clearance (GO:0034383)3.28571899
49regulation of cell fate specification (GO:0042659)3.26208617
50serine family amino acid catabolic process (GO:0009071)3.25272497
51establishment of apical/basal cell polarity (GO:0035089)3.23319228
52outer ear morphogenesis (GO:0042473)3.21664300
53high-density lipoprotein particle remodeling (GO:0034375)3.20619668
54urea metabolic process (GO:0019627)3.16865772
55urea cycle (GO:0000050)3.16865772
56regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15836265
57regulation of fibrinolysis (GO:0051917)3.13719027
58regulation of hippo signaling (GO:0035330)3.10462282
59nuclear pore organization (GO:0006999)3.08596437
60complement activation, alternative pathway (GO:0006957)3.08210512
61peptidyl-glutamic acid carboxylation (GO:0017187)3.07521933
62protein carboxylation (GO:0018214)3.07521933
63dorsal/ventral axis specification (GO:0009950)3.05792027
64cell-cell junction maintenance (GO:0045217)3.05302810
65regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.05212288
66regulation of cholesterol homeostasis (GO:2000188)3.05084722
67regulation of protein activation cascade (GO:2000257)3.04897898
68tryptophan catabolic process (GO:0006569)3.04555528
69indole-containing compound catabolic process (GO:0042436)3.04555528
70indolalkylamine catabolic process (GO:0046218)3.04555528
71post-anal tail morphogenesis (GO:0036342)3.02175441
72digestive tract morphogenesis (GO:0048546)3.01899072
73folic acid-containing compound biosynthetic process (GO:0009396)3.00167277
74dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.00167110
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98916823
76negative regulation of cholesterol transport (GO:0032375)2.98876952
77negative regulation of sterol transport (GO:0032372)2.98876952
78bile acid biosynthetic process (GO:0006699)2.97855266
79basement membrane organization (GO:0071711)2.97469527
80DNA unwinding involved in DNA replication (GO:0006268)2.96378036
81heterochromatin organization (GO:0070828)2.96232101
82histone arginine methylation (GO:0034969)2.96133919
83cranial nerve development (GO:0021545)2.95854004
84tryptophan metabolic process (GO:0006568)2.94500197
85embryonic foregut morphogenesis (GO:0048617)2.91533968
86peptidyl-arginine omega-N-methylation (GO:0035247)2.90949325
87nitrogen cycle metabolic process (GO:0071941)2.90607298
88morphogenesis of an epithelial sheet (GO:0002011)2.86160940
89homocysteine metabolic process (GO:0050667)2.85987684
90regulation of complement activation (GO:0030449)2.84876575
91semaphorin-plexin signaling pathway (GO:0071526)2.84379068
92endocardial cushion development (GO:0003197)2.83362076
93positive regulation of SMAD protein import into nucleus (GO:0060391)2.82934866
94regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.82113474
95serine family amino acid metabolic process (GO:0009069)2.81152613
96anterior/posterior axis specification, embryo (GO:0008595)2.80312748
97cysteine metabolic process (GO:0006534)2.80215510
98cochlea morphogenesis (GO:0090103)2.80211228
99mesenchymal to epithelial transition (GO:0060231)2.80007884
100regulation of mRNA stability (GO:0043488)2.79797381
101regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.79121766
102regulation of gene silencing (GO:0060968)2.77136228
103nerve development (GO:0021675)2.76637459
1043-UTR-mediated mRNA stabilization (GO:0070935)2.72757892
105chromatin assembly (GO:0031497)2.71796388
106reverse cholesterol transport (GO:0043691)2.71629993
107positive regulation of hormone biosynthetic process (GO:0046886)2.71468522
108trophectodermal cell differentiation (GO:0001829)2.70957537
109positive regulation of cell size (GO:0045793)2.70829387
110positive regulation of catenin import into nucleus (GO:0035413)2.70657771
111adherens junction assembly (GO:0034333)2.70148422
112regulation of catenin import into nucleus (GO:0035412)2.68383904
113neural tube development (GO:0021915)2.68302958
114apoptotic process involved in morphogenesis (GO:0060561)2.68038504
115sulfur amino acid catabolic process (GO:0000098)2.67630161
116regulation of somitogenesis (GO:0014807)2.66400158
117gastrulation with mouth forming second (GO:0001702)2.64591457
118tube closure (GO:0060606)2.64588702
119V(D)J recombination (GO:0033151)2.64351575
120serine family amino acid biosynthetic process (GO:0009070)2.64328707
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.64282507
122neural tube closure (GO:0001843)2.63620854
123negative regulation of chondrocyte differentiation (GO:0032331)2.63570871
124positive regulation of fatty acid beta-oxidation (GO:0032000)2.63549270
125exocrine pancreas development (GO:0031017)2.63246015
126alpha-amino acid catabolic process (GO:1901606)2.63127007
127tetrahydrofolate metabolic process (GO:0046653)2.62887964
128mesenchymal cell proliferation (GO:0010463)2.62205938
129establishment of monopolar cell polarity (GO:0061162)2.60943211
130establishment or maintenance of monopolar cell polarity (GO:0061339)2.60943211
131notochord development (GO:0030903)2.60579791
132nuclear pore complex assembly (GO:0051292)2.60411562
133branching involved in salivary gland morphogenesis (GO:0060445)2.60265537
134regulation of non-canonical Wnt signaling pathway (GO:2000050)2.59844987
135protein-lipid complex remodeling (GO:0034368)2.58536543
136macromolecular complex remodeling (GO:0034367)2.58536543
137plasma lipoprotein particle remodeling (GO:0034369)2.58536543
138peptidyl-arginine N-methylation (GO:0035246)2.57784809
139peptidyl-arginine methylation (GO:0018216)2.57784809
140negative regulation of vascular permeability (GO:0043116)2.56918066
141regulation of RNA stability (GO:0043487)2.56537243
142apical protein localization (GO:0045176)2.55260882
143lateral sprouting from an epithelium (GO:0060601)2.54304902
144arginine metabolic process (GO:0006525)2.53695441
145negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.53218874
1464-hydroxyproline metabolic process (GO:0019471)2.52251356
147regulation of cardioblast differentiation (GO:0051890)2.52107620
148bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51834964
149negative regulation of DNA repair (GO:0045738)2.51604062
150dicarboxylic acid biosynthetic process (GO:0043650)2.50367401
151tyrosine metabolic process (GO:0006570)2.50156778
152bile acid metabolic process (GO:0008206)2.50058117
153imidazole-containing compound metabolic process (GO:0052803)2.49969662
154lens fiber cell development (GO:0070307)2.48657913
155embryonic hindlimb morphogenesis (GO:0035116)2.48470132
156peptidyl-lysine dimethylation (GO:0018027)2.48133772
157mesenchyme development (GO:0060485)2.47179767
158acylglycerol homeostasis (GO:0055090)2.46997237
159triglyceride homeostasis (GO:0070328)2.46997237
160heart morphogenesis (GO:0003007)2.46381887
161midbrain development (GO:0030901)2.46000995
162cell junction maintenance (GO:0034331)2.45971053
163regulation of SMAD protein import into nucleus (GO:0060390)2.45945295
164proximal/distal pattern formation (GO:0009954)2.45689449
165embryonic camera-type eye development (GO:0031076)2.45585802
166regulation of translational fidelity (GO:0006450)2.45151795
167negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.45140771
168fibrinolysis (GO:0042730)2.45133053
169regulation of triglyceride catabolic process (GO:0010896)2.44455047
170epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44370468
171protein complex localization (GO:0031503)2.44101717
172cranial suture morphogenesis (GO:0060363)2.43390139
173placenta development (GO:0001890)2.42589625
174craniofacial suture morphogenesis (GO:0097094)2.41960014
175embryonic digestive tract development (GO:0048566)2.41611483
176negative regulation of histone methylation (GO:0031061)2.40896935
177hindlimb morphogenesis (GO:0035137)2.40522245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.73030093
2E2F7_22180533_ChIP-Seq_HELA_Human4.03436492
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.84363189
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.70041582
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.59865837
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.41777509
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.22556152
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.10879168
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.05138092
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73693755
11CLOCK_20551151_ChIP-Seq_293T_Human2.68931563
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.53289889
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.53289889
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.53289889
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46701398
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.42076337
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.34557029
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.23712323
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20371209
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.19576937
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.17539878
22* KDM2B_26808549_Chip-Seq_K562_Human2.14019755
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.13089388
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.04630718
25TP63_19390658_ChIP-ChIP_HaCaT_Human2.01271305
26TCF3_18692474_ChIP-Seq_MEFs_Mouse1.99470489
27AR_21909140_ChIP-Seq_LNCAP_Human1.97924469
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.93729465
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90823002
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90312265
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87334632
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.84842106
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83556343
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82308957
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80233650
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80122063
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76766023
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.75336812
39* KDM2B_26808549_Chip-Seq_DND41_Human1.70897450
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70285411
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66840271
42SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.65964539
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65678389
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65304969
45OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.64147021
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64085619
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62109161
48LXR_22292898_ChIP-Seq_THP-1_Human1.61678045
49* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60651186
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57293337
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56229073
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.56166019
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55790621
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52431878
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52378711
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50728901
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.48824271
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48075373
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46092271
60TCF7_22412390_ChIP-Seq_EML_Mouse1.45676404
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42098070
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41937267
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40505990
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40043311
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38566437
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38566437
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38500163
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.38413279
69MYC_22102868_ChIP-Seq_BL_Human1.38193532
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37734062
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37206400
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36537364
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36064599
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.35919209
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.35807040
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35804760
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.35405977
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35390773
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35022904
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34826806
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34333529
82XRN2_22483619_ChIP-Seq_HELA_Human1.33821779
83* CTCF_27219007_Chip-Seq_Bcells_Human1.32548127
84SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32396873
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30570479
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.29685977
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29041892
88POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28659187
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28510795
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.28351931
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28060723
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27750355
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26256765
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25314703
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.25218749
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24825538
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.24587554
98* KDM2B_26808549_Chip-Seq_JURKAT_Human1.24506274
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.24089117
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22954834
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.21607296
102SOX3_22085726_ChIP-Seq_NPCs_Mouse1.21014281
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20902386
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20687843
105RACK7_27058665_Chip-Seq_MCF-7_Human1.20123101
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.19014097
107EZH2_27304074_Chip-Seq_ESCs_Mouse1.18702470
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18420226
109MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17085522
110EED_16625203_ChIP-ChIP_MESCs_Mouse1.16667009
111VDR_21846776_ChIP-Seq_THP-1_Human1.15957131
112* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15882072
113EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15370164
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15095749
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14727400
116GATA1_26923725_Chip-Seq_HPCs_Mouse1.14488597
117ATF3_27146783_Chip-Seq_COLON_Human1.13006389
118POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12169672
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11390426
120GATA6_25053715_ChIP-Seq_YYC3_Human1.11242521
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10916984
122P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10755473
123CREB1_26743006_Chip-Seq_LNCaP_Human1.10156492
124SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08665054
125CHD1_26751641_Chip-Seq_LNCaP_Human1.08107016
126* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07687282
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07428124
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06686917
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06544063
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06340696
131KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03916546
132KAP1_27257070_Chip-Seq_ESCs_Mouse1.03796102
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03545179
134NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02957619
135ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01463075
136PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.00564556
137NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00540410
138NANOG_16153702_ChIP-ChIP_HESCs_Human0.97869339
139E2F1_21310950_ChIP-Seq_MCF-7_Human0.97335786
140SOX17_20123909_ChIP-Seq_XEN_Mouse0.95780037
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.95603789
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94634070
143ZNF263_19887448_ChIP-Seq_K562_Human0.94548250
144FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94290242
145TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.92838861
146POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92723589
147DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92648299
148TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92645476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.65830429
2MP0005360_urolithiasis3.55857768
3MP0003705_abnormal_hypodermis_morpholog3.45565043
4MP0009053_abnormal_anal_canal3.22415793
5MP0010030_abnormal_orbit_morphology3.07945091
6MP0003123_paternal_imprinting3.03501721
7MP0000537_abnormal_urethra_morphology2.75624544
8MP0003122_maternal_imprinting2.72628578
9MP0005085_abnormal_gallbladder_physiolo2.70779878
10MP0004272_abnormal_basement_membrane2.56884479
11MP0005365_abnormal_bile_salt2.49495853
12MP0005377_hearing/vestibular/ear_phenot2.37381511
13MP0003878_abnormal_ear_physiology2.37381511
14MP0003567_abnormal_fetal_cardiomyocyte2.26145859
15MP0003806_abnormal_nucleotide_metabolis2.25535012
16MP0004858_abnormal_nervous_system2.24187330
17MP0010368_abnormal_lymphatic_system2.11050345
18MP0003283_abnormal_digestive_organ2.10633757
19MP0003121_genomic_imprinting2.06225479
20MP0002089_abnormal_postnatal_growth/wei2.01836127
21MP0002233_abnormal_nose_morphology1.99740135
22MP0005083_abnormal_biliary_tract1.90133524
23MP0001299_abnormal_eye_distance/1.81667440
24MP0003119_abnormal_digestive_system1.77980058
25MP0004197_abnormal_fetal_growth/weight/1.75214234
26MP0003385_abnormal_body_wall1.72885398
27MP0005257_abnormal_intraocular_pressure1.72725435
28MP0003937_abnormal_limbs/digits/tail_de1.71238898
29MP0005076_abnormal_cell_differentiation1.70624641
30MP0004264_abnormal_extraembryonic_tissu1.68808531
31MP0003252_abnormal_bile_duct1.67461547
32MP0009840_abnormal_foam_cell1.65463683
33MP0003890_abnormal_embryonic-extraembry1.65326819
34MP0009672_abnormal_birth_weight1.65155799
35MP0003861_abnormal_nervous_system1.58105647
36MP0008875_abnormal_xenobiotic_pharmacok1.56388190
37MP0002249_abnormal_larynx_morphology1.52715715
38MP0002697_abnormal_eye_size1.52127572
39MP0000778_abnormal_nervous_system1.51716997
40MP0003566_abnormal_cell_adhesion1.50384767
41MP0005380_embryogenesis_phenotype1.49769412
42MP0001672_abnormal_embryogenesis/_devel1.49769412
43MP0010329_abnormal_lipoprotein_level1.49326173
44MP0001730_embryonic_growth_arrest1.47553433
45MP0002088_abnormal_embryonic_growth/wei1.46492809
46MP0006292_abnormal_olfactory_placode1.44832243
47MP0002086_abnormal_extraembryonic_tissu1.43555642
48MP0003984_embryonic_growth_retardation1.43289622
49MP0002084_abnormal_developmental_patter1.42883995
50MP0009278_abnormal_bone_marrow1.40962878
51MP0000566_synostosis1.40529233
52MP0001346_abnormal_lacrimal_gland1.40500457
53MP0010352_gastrointestinal_tract_polyps1.40198452
54MP0005623_abnormal_meninges_morphology1.37796966
55MP0002254_reproductive_system_inflammat1.36939989
56MP0005409_darkened_coat_color1.36207208
57MP0003115_abnormal_respiratory_system1.33284463
58MP0002653_abnormal_ependyma_morphology1.32843613
59MP0005394_taste/olfaction_phenotype1.30668155
60MP0005499_abnormal_olfactory_system1.30668155
61MP0002282_abnormal_trachea_morphology1.29305985
62MP0001293_anophthalmia1.28748131
63MP0002116_abnormal_craniofacial_bone1.28204214
64MP0002085_abnormal_embryonic_tissue1.27644738
65MP0005187_abnormal_penis_morphology1.27278626
66MP0001697_abnormal_embryo_size1.26114978
67MP0003221_abnormal_cardiomyocyte_apopto1.25092848
68MP0003942_abnormal_urinary_system1.21293036
69MP0002111_abnormal_tail_morphology1.21121855
70MP0000428_abnormal_craniofacial_morphol1.20846364
71MP0005248_abnormal_Harderian_gland1.17610135
72MP0000049_abnormal_middle_ear1.16071071
73MP0002932_abnormal_joint_morphology1.15332075
74MP0001879_abnormal_lymphatic_vessel1.15269942
75MP0001915_intracranial_hemorrhage1.15078798
76MP0003941_abnormal_skin_development1.14081441
77MP0002092_abnormal_eye_morphology1.12751911
78MP0004957_abnormal_blastocyst_morpholog1.08500461
79MP0003136_yellow_coat_color1.07044428
80MP0004233_abnormal_muscle_weight1.06119361
81MP0003935_abnormal_craniofacial_develop1.04510859
82MP0005332_abnormal_amino_acid1.04331148
83MP0002081_perinatal_lethality1.04318338
84MP0005023_abnormal_wound_healing1.03218327
85MP0009703_decreased_birth_body1.03195460
86MP0000462_abnormal_digestive_system1.03032397
87MP0002822_catalepsy1.02868909
88MP0009697_abnormal_copulation1.01182547
89MP0002925_abnormal_cardiovascular_devel0.97930274
90MP0005451_abnormal_body_composition0.95525040
91MP0001849_ear_inflammation0.94927898
92MP0002127_abnormal_cardiovascular_syste0.94686977
93MP0000534_abnormal_ureter_morphology0.92904112
94MP0008932_abnormal_embryonic_tissue0.91668019
95MP0002152_abnormal_brain_morphology0.91463309
96MP0002080_prenatal_lethality0.91277157
97MP0002938_white_spotting0.89451784
98MP0001666_abnormal_nutrient_absorption0.88624052
99MP0001286_abnormal_eye_development0.88481956
100MP0010630_abnormal_cardiac_muscle0.88364900
101MP0005391_vision/eye_phenotype0.88128943
102MP0010234_abnormal_vibrissa_follicle0.88032819
103MP0000733_abnormal_muscle_development0.87744936
104MP0002751_abnormal_autonomic_nervous0.87555193
105MP0003077_abnormal_cell_cycle0.87373716
106MP0004019_abnormal_vitamin_homeostasis0.86128227
107MP0001340_abnormal_eyelid_morphology0.84154195
108MP0000516_abnormal_urinary_system0.83428549
109MP0005367_renal/urinary_system_phenotyp0.83428549
110MP0008789_abnormal_olfactory_epithelium0.82515939
111MP0003755_abnormal_palate_morphology0.81324611
112MP0000350_abnormal_cell_proliferation0.81177842
113MP0000609_abnormal_liver_physiology0.80619180
114MP0003315_abnormal_perineum_morphology0.80567508
115MP0004185_abnormal_adipocyte_glucose0.79204873
116MP0004133_heterotaxia0.78838734
117MP0000762_abnormal_tongue_morphology0.78720757
118MP0001614_abnormal_blood_vessel0.78687039
119MP0010678_abnormal_skin_adnexa0.78621125
120MP0002184_abnormal_innervation0.78590973
121MP0000477_abnormal_intestine_morphology0.78503514
122MP0000767_abnormal_smooth_muscle0.78446391
123MP0000598_abnormal_liver_morphology0.77832605
124MP0003111_abnormal_nucleus_morphology0.77747595
125MP0000383_abnormal_hair_follicle0.77613972
126MP0003693_abnormal_embryo_hatching0.77514016
127MP0000432_abnormal_head_morphology0.76966015
128MP0004084_abnormal_cardiac_muscle0.76887537
129MP0001984_abnormal_olfaction0.76841788
130MP0009250_abnormal_appendicular_skeleto0.76687565
131MP0002114_abnormal_axial_skeleton0.76507967
132MP0003938_abnormal_ear_development0.74400296
133MP0002128_abnormal_blood_circulation0.73683280

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.70475610
2Vitreoretinal degeneration (HP:0000655)4.31815927
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.12227437
4Intrahepatic cholestasis (HP:0001406)3.96510105
5Xanthomatosis (HP:0000991)3.64086537
6Hypobetalipoproteinemia (HP:0003563)3.50776653
7Renal duplication (HP:0000075)3.34020386
8Pseudobulbar signs (HP:0002200)3.28661912
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.08635806
10Partial duplication of thumb phalanx (HP:0009944)3.06765509
11Spastic diplegia (HP:0001264)2.84463245
12Epidermoid cyst (HP:0200040)2.81581416
13Aplasia involving bones of the upper limbs (HP:0009823)2.80632885
14Aplasia of the phalanges of the hand (HP:0009802)2.80632885
15Aplasia involving bones of the extremities (HP:0009825)2.80632885
16Back pain (HP:0003418)2.76596860
17Complement deficiency (HP:0004431)2.72935712
18Turricephaly (HP:0000262)2.71367402
19Abnormality of pyrimidine metabolism (HP:0004353)2.69001434
20Abnormality of the aortic arch (HP:0012303)2.68916701
21Shallow orbits (HP:0000586)2.68221260
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67506721
23Short 4th metacarpal (HP:0010044)2.67506721
24Esophageal varix (HP:0002040)2.66948029
25Thin ribs (HP:0000883)2.66261829
26Metaphyseal cupping (HP:0003021)2.65828901
27Prolonged partial thromboplastin time (HP:0003645)2.64611193
28Broad palm (HP:0001169)2.58993975
29Broad phalanges of the hand (HP:0009768)2.58269834
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58237433
31Abnormality of the 4th metacarpal (HP:0010012)2.55594807
32Cutaneous syndactyly (HP:0012725)2.53027711
33Broad finger (HP:0001500)2.52072870
34Skull defect (HP:0001362)2.51748673
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.50596755
36Broad metatarsal (HP:0001783)2.49697636
37Hepatoblastoma (HP:0002884)2.48660254
38Cutaneous finger syndactyly (HP:0010554)2.46070203
39Neonatal short-limb short stature (HP:0008921)2.41673778
40Mixed hearing impairment (HP:0000410)2.40896493
41Hyperglycinemia (HP:0002154)2.39617406
42Hypolipoproteinemia (HP:0010981)2.36418755
43Abnormality of the lumbar spine (HP:0100712)2.33696834
44Diastasis recti (HP:0001540)2.33389390
45Coronal craniosynostosis (HP:0004440)2.32573684
46Broad phalanx (HP:0006009)2.31272343
47Hepatocellular carcinoma (HP:0001402)2.27753078
48Broad long bones (HP:0005622)2.27221359
49Abnormality of the common coagulation pathway (HP:0010990)2.27080030
50Bilateral microphthalmos (HP:0007633)2.22332421
51Vertebral clefting (HP:0008428)2.20792865
52Abnormality of complement system (HP:0005339)2.18538830
53Anophthalmia (HP:0000528)2.18326447
54Midline defect of the nose (HP:0004122)2.18232469
55Abnormality of glycine metabolism (HP:0010895)2.17947633
56Abnormality of serine family amino acid metabolism (HP:0010894)2.17947633
57Hypoglycemic coma (HP:0001325)2.17883594
58Lymphangioma (HP:0100764)2.17237974
59Fused cervical vertebrae (HP:0002949)2.17028619
60Hyperglycinuria (HP:0003108)2.15876095
61Hyperammonemia (HP:0001987)2.15502972
62Hyperlipoproteinemia (HP:0010980)2.15166906
63Aqueductal stenosis (HP:0002410)2.14814005
64Broad thumb (HP:0011304)2.11422707
65Selective tooth agenesis (HP:0001592)2.08515726
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.07430276
67Abnormality of the calcaneus (HP:0008364)2.07415512
68Thoracic kyphosis (HP:0002942)2.06782770
69Abnormality of the phalanges of the 2nd finger (HP:0009541)2.05624462
70Abnormality of the ischium (HP:0003174)2.05232720
71Hypoplastic ischia (HP:0003175)2.03462602
72Exercise-induced muscle cramps (HP:0003710)2.02991409
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02689876
74Duplication of thumb phalanx (HP:0009942)2.02426143
75Septo-optic dysplasia (HP:0100842)2.00609042
76Asymmetry of the thorax (HP:0001555)1.98673201
77Anal stenosis (HP:0002025)1.98389035
78Skin nodule (HP:0200036)1.97732125
79Disproportionate tall stature (HP:0001519)1.97377009
80Esophageal atresia (HP:0002032)1.95771574
81Tracheomalacia (HP:0002779)1.95639046
82Reticulocytosis (HP:0001923)1.95565871
83Thoracolumbar scoliosis (HP:0002944)1.95149625
84Pancreatic islet-cell hyperplasia (HP:0004510)1.95067830
85Right ventricular cardiomyopathy (HP:0011663)1.92950799
86Vertebral fusion (HP:0002948)1.90873210
87Overriding aorta (HP:0002623)1.89607522
88Abnormality of methionine metabolism (HP:0010901)1.88959993
89Joint hemorrhage (HP:0005261)1.87830281
90Absent epiphyses (HP:0010577)1.87714667
91Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87714667
92Supernumerary ribs (HP:0005815)1.87624527
93Broad hallux (HP:0010055)1.87339453
94Absent eyebrow (HP:0002223)1.87067987
95Capillary hemangiomas (HP:0005306)1.86882825
96Bronchomalacia (HP:0002780)1.86036283
97Abnormality of the pubic bones (HP:0003172)1.85337019
98Abnormality of the diencephalon (HP:0010662)1.85212221
99Buphthalmos (HP:0000557)1.84626456
100Short middle phalanx of finger (HP:0005819)1.83824914
101Hypoalphalipoproteinemia (HP:0003233)1.83538327
102High anterior hairline (HP:0009890)1.83263399
103Rib fusion (HP:0000902)1.83233521
104Abnormal tarsal ossification (HP:0008369)1.83042393
105Midface retrusion (HP:0011800)1.82972714
106Generalized hypotonia (HP:0001290)1.82888165
107Abnormality of the columella (HP:0009929)1.82774135
108Hypercholesterolemia (HP:0003124)1.82647683
109Flat acetabular roof (HP:0003180)1.81897085
110Deep palmar crease (HP:0006191)1.81734736
111Long palpebral fissure (HP:0000637)1.81054195
112Renovascular hypertension (HP:0100817)1.80945454
113Enlarged kidneys (HP:0000105)1.78723596
114Vaginal fistula (HP:0004320)1.78395107
115Omphalocele (HP:0001539)1.78345176
116Abnormality of the thoracic spine (HP:0100711)1.78283312
117Choanal stenosis (HP:0000452)1.77972859
118Delayed CNS myelination (HP:0002188)1.77926093
119Abnormal vertebral ossification (HP:0100569)1.77402592
120Deviation of the thumb (HP:0009603)1.77359787
121Abnormal number of incisors (HP:0011064)1.77340495
122Abnormality of the intervertebral disk (HP:0005108)1.77246906
123Short 5th finger (HP:0009237)1.76789855
124Broad distal phalanx of finger (HP:0009836)1.76265321
125Fat malabsorption (HP:0002630)1.75676680
126Broad toe (HP:0001837)1.75477310
127Hypoglycemic seizures (HP:0002173)1.75328977
128Hemivertebrae (HP:0002937)1.75206588
129Anteriorly placed anus (HP:0001545)1.75192886
130Myelomeningocele (HP:0002475)1.74770759
131Intestinal atresia (HP:0011100)1.73886228
132Epiphyseal dysplasia (HP:0002656)1.73855173
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72924715
134Long eyelashes (HP:0000527)1.72302826
135Arnold-Chiari malformation (HP:0002308)1.70990188
136Renal hypoplasia (HP:0000089)1.70711516
137Increased nuchal translucency (HP:0010880)1.70296295
138Preaxial foot polydactyly (HP:0001841)1.69770669
139Synostosis of carpal bones (HP:0005048)1.69458221
140Increased mean platelet volume (HP:0011877)1.68952693
141Intestinal fistula (HP:0100819)1.68563288
142Ketosis (HP:0001946)1.68549743
143Ependymoma (HP:0002888)1.68506740
144Trigonocephaly (HP:0000243)1.66512271
145Abnormality of the lacrimal duct (HP:0011481)1.66300350
146Partial duplication of the phalanx of hand (HP:0009999)1.65734020
147Ulnar bowing (HP:0003031)1.65666172
148Alacrima (HP:0000522)1.65597755
149Bicornuate uterus (HP:0000813)1.64830312
150Elfin facies (HP:0004428)1.64608008
151Hemorrhage of the eye (HP:0011885)1.64521823
152Neonatal death (HP:0003811)1.64434572
153Thickened helices (HP:0000391)1.63839748
154Spina bifida occulta (HP:0003298)1.63659924
155Abnormality of the distal phalanx of the thumb (HP:0009617)1.62396797
156Hyperacusis (HP:0010780)1.62149151
157Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.62110465
158Abnormality of endocrine pancreas physiology (HP:0012093)1.61553805
159Abnormality of the pancreatic islet cells (HP:0006476)1.61553805
160Glomerulosclerosis (HP:0000096)1.60984661
161Chorioretinal atrophy (HP:0000533)1.59871999
162Abnormality of the parietal bone (HP:0002696)1.59604357
163Subacute progressive viral hepatitis (HP:0006572)1.59302055
164Abnormality of nucleobase metabolism (HP:0010932)1.58369162
165Supernumerary bones of the axial skeleton (HP:0009144)1.58113654
166Carpal synostosis (HP:0009702)1.57659614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.27376011
2MAP3K103.16420836
3CDK122.94945711
4PKN22.77687082
5LATS22.64780207
6EPHB22.55828044
7SMG12.55342070
8PLK42.34897045
9CDC72.15603493
10TRIB32.05187250
11STK38L1.98743429
12PTK61.95412732
13TGFBR11.93301389
14ICK1.75985116
15PDGFRA1.73238760
16RPS6KB21.65127966
17MET1.65118091
18NEK11.64405263
19SIK11.63922954
20BCKDK1.63800304
21FGFR11.63119753
22BRD41.60054184
23NTRK11.59189946
24STK101.58828073
25TSSK61.57232949
26MKNK11.55429777
27PTK21.50376367
28FGFR21.49634324
29MAP3K81.49559857
30TLK11.38595764
31RIPK11.38223962
32TTK1.35532621
33MTOR1.33424224
34PASK1.32890496
35EEF2K1.31497905
36STK31.28566884
37CDK61.27940692
38ERN11.26516977
39ERBB41.26068803
40ALK1.24498110
41CDK71.22044662
42EPHA21.20367127
43ERBB21.19775309
44PAK41.19436318
45TTN1.18807283
46NEK21.17591226
47FGFR41.17588185
48CDK41.17580536
49MAP2K31.14046405
50PAK21.09844934
51KDR1.07410255
52SRPK11.04705377
53TIE11.04545762
54BCR1.04348395
55BMX1.01046652
56LRRK21.00382270
57WEE10.97604641
58DYRK20.94324509
59FLT30.93019453
60CAMK1D0.92092790
61DYRK30.90439502
62PBK0.89958063
63FER0.87968110
64CDK190.87361155
65FGFR30.85914675
66CSNK1G30.85712512
67CSNK1G10.85690742
68NEK90.84483614
69AKT20.82816345
70NTRK20.79883178
71MAP3K90.79788732
72PRKD30.79755807
73RPS6KA20.76811720
74MELK0.75562880
75MAP2K20.75215565
76CAMK1G0.73696039
77SGK4940.72494415
78SGK2230.72494415
79FGR0.70201931
80MAP2K70.69010586
81MKNK20.67722553
82TAF10.67478457
83EPHA40.66967030
84NLK0.66898795
85PLK30.66059237
86RET0.64212212
87CSNK1E0.62720506
88CSNK1G20.62562000
89CHEK10.59712296
90LIMK10.57446745
91KSR10.57255420
92DYRK1B0.56910519
93AURKB0.55979094
94MARK20.54682085
95CDK20.52674548
96MAP3K30.52090888
97PAK30.51560732
98ILK0.50543340
99PDGFRB0.50423178
100FES0.50397818
101RPS6KC10.49578978
102RPS6KL10.49578978
103PLK10.48285824
104CSNK1D0.48126768
105PAK10.48098496
106CDK140.48013193
107ATM0.47997315
108CDK11A0.47712638
109RPS6KA40.47147408
110AURKA0.46296550
111CDK150.45656064
112TYRO30.43109350
113CDK30.42655386
114CDK180.42637804
115AKT10.42140601
116STK40.41946069
117CDK10.40748257
118MAP3K110.40708619
119OBSCN0.40473206
120RPS6KA10.40184950
121CDK90.39988847
122MAP3K70.39886484
123CDC42BPA0.39619231
124MAPK90.38728745
125TGFBR20.38378537
126SCYL20.37853212
127BRAF0.37530932
128CHEK20.37173317
129ATR0.36750860
130GSK3A0.35192233
131DAPK30.35094040
132CAMK40.34877495
133EGFR0.34863169
134WNK40.34613338
135CSNK1A1L0.34141095
136DDR20.31759356
137PRKCI0.31204701
138MST1R0.31117132
139CLK10.30835926

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19675721
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.19611409
3Nitrogen metabolism_Homo sapiens_hsa009103.09056091
4Arginine biosynthesis_Homo sapiens_hsa002202.78449381
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.77689594
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51072733
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44662990
8Complement and coagulation cascades_Homo sapiens_hsa046102.30639621
9One carbon pool by folate_Homo sapiens_hsa006702.13235045
10Axon guidance_Homo sapiens_hsa043602.11529056
11Tryptophan metabolism_Homo sapiens_hsa003802.07676918
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02909007
13Endometrial cancer_Homo sapiens_hsa052131.95337968
14Melanogenesis_Homo sapiens_hsa049161.85066752
15Fatty acid degradation_Homo sapiens_hsa000711.84922159
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84680451
17Basal cell carcinoma_Homo sapiens_hsa052171.84608117
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83722673
19Biosynthesis of amino acids_Homo sapiens_hsa012301.79190115
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.75743337
21Selenocompound metabolism_Homo sapiens_hsa004501.74257519
22Lysine degradation_Homo sapiens_hsa003101.71718581
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63425203
24Fatty acid metabolism_Homo sapiens_hsa012121.60972831
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52934918
26Butanoate metabolism_Homo sapiens_hsa006501.52683643
27Carbon metabolism_Homo sapiens_hsa012001.52056879
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.51195075
29Colorectal cancer_Homo sapiens_hsa052101.49556419
30PPAR signaling pathway_Homo sapiens_hsa033201.49241374
31Propanoate metabolism_Homo sapiens_hsa006401.48558308
32Alcoholism_Homo sapiens_hsa050341.47366910
33Staphylococcus aureus infection_Homo sapiens_hsa051501.45567624
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.43138076
35Phenylalanine metabolism_Homo sapiens_hsa003601.42974779
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41342872
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37342320
38Hippo signaling pathway_Homo sapiens_hsa043901.37127227
39Fat digestion and absorption_Homo sapiens_hsa049751.36185341
40Retinol metabolism_Homo sapiens_hsa008301.35192327
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.29508190
42Gap junction_Homo sapiens_hsa045401.27058754
43Chronic myeloid leukemia_Homo sapiens_hsa052201.26111434
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25355138
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25343203
46Bile secretion_Homo sapiens_hsa049761.24584840
47Rap1 signaling pathway_Homo sapiens_hsa040151.24022946
48beta-Alanine metabolism_Homo sapiens_hsa004101.19813516
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18207754
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.17737401
51Peroxisome_Homo sapiens_hsa041461.17477448
52Pyruvate metabolism_Homo sapiens_hsa006201.17268854
53Hedgehog signaling pathway_Homo sapiens_hsa043401.16043457
54Chemical carcinogenesis_Homo sapiens_hsa052041.11868151
55Tyrosine metabolism_Homo sapiens_hsa003501.11639606
56Adherens junction_Homo sapiens_hsa045201.10725641
57Caffeine metabolism_Homo sapiens_hsa002321.07270986
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.06764909
59Histidine metabolism_Homo sapiens_hsa003401.06483589
60Glioma_Homo sapiens_hsa052141.06050903
61Steroid biosynthesis_Homo sapiens_hsa001001.05988435
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05935189
63ErbB signaling pathway_Homo sapiens_hsa040121.01553598
64Central carbon metabolism in cancer_Homo sapiens_hsa052301.00879385
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99957495
66Non-small cell lung cancer_Homo sapiens_hsa052230.97995446
67Fatty acid elongation_Homo sapiens_hsa000620.96607066
68Arginine and proline metabolism_Homo sapiens_hsa003300.96364677
69Insulin signaling pathway_Homo sapiens_hsa049100.95840287
70RNA transport_Homo sapiens_hsa030130.95232591
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.94929817
72Spliceosome_Homo sapiens_hsa030400.94437288
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94387645
74AMPK signaling pathway_Homo sapiens_hsa041520.92599957
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92189998
76Protein digestion and absorption_Homo sapiens_hsa049740.90900222
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88881814
78VEGF signaling pathway_Homo sapiens_hsa043700.85781692
79Choline metabolism in cancer_Homo sapiens_hsa052310.85223517
80Notch signaling pathway_Homo sapiens_hsa043300.84889674
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.82355263
82Starch and sucrose metabolism_Homo sapiens_hsa005000.81180847
83Proteoglycans in cancer_Homo sapiens_hsa052050.81104257
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79685139
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79272179
86TGF-beta signaling pathway_Homo sapiens_hsa043500.77584631
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75851784
88MicroRNAs in cancer_Homo sapiens_hsa052060.75279931
89Bladder cancer_Homo sapiens_hsa052190.74910141
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74430833
91Base excision repair_Homo sapiens_hsa034100.74249849
92Tight junction_Homo sapiens_hsa045300.71254293
93Ras signaling pathway_Homo sapiens_hsa040140.70258249
94mRNA surveillance pathway_Homo sapiens_hsa030150.69773955
95Estrogen signaling pathway_Homo sapiens_hsa049150.69445335
96Non-homologous end-joining_Homo sapiens_hsa034500.69340825
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68496853
98Melanoma_Homo sapiens_hsa052180.68169941
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67611892
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67334375
101Viral carcinogenesis_Homo sapiens_hsa052030.66218794
102Folate biosynthesis_Homo sapiens_hsa007900.65881038
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63716837
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63402514
105Pentose phosphate pathway_Homo sapiens_hsa000300.63178625
106Prion diseases_Homo sapiens_hsa050200.62900782
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.62408844
108Cell cycle_Homo sapiens_hsa041100.62133180
109Glucagon signaling pathway_Homo sapiens_hsa049220.61629793
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61440452
111Sulfur relay system_Homo sapiens_hsa041220.60834501
112Vitamin digestion and absorption_Homo sapiens_hsa049770.58914326
113Acute myeloid leukemia_Homo sapiens_hsa052210.57887300
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57835104
115Inositol phosphate metabolism_Homo sapiens_hsa005620.57812370
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57242230
117Systemic lupus erythematosus_Homo sapiens_hsa053220.57057377
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55547292
119Glutathione metabolism_Homo sapiens_hsa004800.55292903
120mTOR signaling pathway_Homo sapiens_hsa041500.55068925
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.53805652
122Small cell lung cancer_Homo sapiens_hsa052220.53630755
123Long-term potentiation_Homo sapiens_hsa047200.51381550
124Oocyte meiosis_Homo sapiens_hsa041140.51350567
125ECM-receptor interaction_Homo sapiens_hsa045120.50571412
126Dilated cardiomyopathy_Homo sapiens_hsa054140.50073737
127HTLV-I infection_Homo sapiens_hsa051660.49847100
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49795103
129Apoptosis_Homo sapiens_hsa042100.49337828
130Mismatch repair_Homo sapiens_hsa034300.48873348
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48710716
132Glycerolipid metabolism_Homo sapiens_hsa005610.48496354
133Thyroid cancer_Homo sapiens_hsa052160.48175266
134Pancreatic cancer_Homo sapiens_hsa052120.46330525
135DNA replication_Homo sapiens_hsa030300.46107079
136Renal cell carcinoma_Homo sapiens_hsa052110.46066037
137Insulin resistance_Homo sapiens_hsa049310.45485778
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43722667
139MAPK signaling pathway_Homo sapiens_hsa040100.42137161
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41849228
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41272757
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38660808
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38550199
144Galactose metabolism_Homo sapiens_hsa000520.37841413
145Oxytocin signaling pathway_Homo sapiens_hsa049210.37397406
146GnRH signaling pathway_Homo sapiens_hsa049120.36982503
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.36164160
148Focal adhesion_Homo sapiens_hsa045100.35621740
149Wnt signaling pathway_Homo sapiens_hsa043100.31795244
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31132455
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30540012
152Amoebiasis_Homo sapiens_hsa051460.29859127
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28596878
154Sulfur metabolism_Homo sapiens_hsa009200.27423437
155Pathways in cancer_Homo sapiens_hsa052000.27301537
156Legionellosis_Homo sapiens_hsa051340.26755208
157Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26408165
158Prostate cancer_Homo sapiens_hsa052150.25735120
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24987696

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