FILIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.07259178
2cardiac myofibril assembly (GO:0055003)7.07729869
3actin-myosin filament sliding (GO:0033275)7.01273720
4muscle filament sliding (GO:0030049)7.01273720
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.76087928
6myofibril assembly (GO:0030239)6.64323580
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.42795799
8negative regulation of potassium ion transmembrane transport (GO:1901380)6.27033570
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.22356000
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.16627402
11regulation of skeletal muscle contraction (GO:0014819)5.94762102
12actin-mediated cell contraction (GO:0070252)5.92367960
13plasma membrane repair (GO:0001778)5.88790074
14cardiac muscle contraction (GO:0060048)5.81468013
15sarcoplasmic reticulum calcium ion transport (GO:0070296)5.69679006
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.48670803
17actomyosin structure organization (GO:0031032)5.42648069
18cardiac muscle cell development (GO:0055013)5.22291805
19regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.17509310
20regulation of relaxation of muscle (GO:1901077)5.07257165
21striated muscle contraction (GO:0006941)5.01349335
22regulation of actin filament-based movement (GO:1903115)4.92940945
23cardiac cell development (GO:0055006)4.91415036
24ventricular cardiac muscle cell action potential (GO:0086005)4.89733572
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.87672623
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.85836874
27regulation of cell communication by electrical coupling (GO:0010649)4.82105017
28cardiac muscle tissue morphogenesis (GO:0055008)4.70874812
29cardiac muscle hypertrophy (GO:0003300)4.69381812
30actin filament-based movement (GO:0030048)4.65484737
31cell communication involved in cardiac conduction (GO:0086065)4.51461601
32adult heart development (GO:0007512)4.50735586
33striated muscle hypertrophy (GO:0014897)4.49146914
34regulation of sarcomere organization (GO:0060297)4.45795334
35regulation of membrane repolarization (GO:0060306)4.44459022
36regulation of striated muscle contraction (GO:0006942)4.42224528
37response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.41250173
38bundle of His cell to Purkinje myocyte communication (GO:0086069)4.39154706
39tricarboxylic acid cycle (GO:0006099)4.36437385
40muscle tissue morphogenesis (GO:0060415)4.32192214
41cell communication by electrical coupling (GO:0010644)4.31375494
42ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.28922815
43heart process (GO:0003015)4.28419909
44heart contraction (GO:0060047)4.28419909
45detection of calcium ion (GO:0005513)4.26735441
46cardiac chamber formation (GO:0003207)4.26644773
47carnitine shuttle (GO:0006853)4.24457869
48adrenergic receptor signaling pathway (GO:0071875)4.14027684
49heart trabecula formation (GO:0060347)4.09730815
50skeletal muscle contraction (GO:0003009)3.98657813
51regulation of the force of heart contraction (GO:0002026)3.97592722
52positive regulation of cardiac muscle cell differentiation (GO:2000727)3.89590288
53muscle hypertrophy (GO:0014896)3.88077503
54response to muscle activity (GO:0014850)3.87834464
55regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.80090852
56response to inactivity (GO:0014854)3.77947856
57response to caffeine (GO:0031000)3.77338011
58cardiac muscle cell action potential (GO:0086001)3.76202486
59positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.70830236
60regulation of cardiac muscle contraction (GO:0055117)3.67377956
61cardiac muscle cell action potential involved in contraction (GO:0086002)3.65886175
62relaxation of cardiac muscle (GO:0055119)3.65449873
63negative regulation of potassium ion transport (GO:0043267)3.65038205
64relaxation of muscle (GO:0090075)3.64757419
65fatty acid transmembrane transport (GO:1902001)3.62990618
66regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.58737979
67muscle contraction (GO:0006936)3.57895069
68cardiac ventricle formation (GO:0003211)3.57804391
69regulation of heart rate (GO:0002027)3.52342018
70regulation of calcium ion transmembrane transporter activity (GO:1901019)3.51551527
71regulation of calcium ion transmembrane transport (GO:1903169)3.51551527
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50956015
73regulation of acyl-CoA biosynthetic process (GO:0050812)3.43928207
74negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.43768012
75cardiac conduction (GO:0061337)3.42662733
76striated muscle cell development (GO:0055002)3.38359813
77muscle system process (GO:0003012)3.33193008
78regulation of heart rate by cardiac conduction (GO:0086091)3.31867535
79regulation of cardiac muscle cell contraction (GO:0086004)3.30829621
80regulation of heart contraction (GO:0008016)3.30782728
81positive regulation of cation channel activity (GO:2001259)3.30768431
82negative regulation of protein localization to cell surface (GO:2000009)3.28859789
83neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.24213221
84otic vesicle formation (GO:0030916)3.20479222
85negative regulation of striated muscle cell apoptotic process (GO:0010664)3.17745009
86muscle fiber development (GO:0048747)3.16113134
87negative regulation of cytosolic calcium ion concentration (GO:0051481)3.14128024
88positive regulation of myoblast differentiation (GO:0045663)3.10364436
89regulation of muscle contraction (GO:0006937)3.10018580
90growth hormone secretion (GO:0030252)3.09671979
91cardiac muscle hypertrophy in response to stress (GO:0014898)3.09565644
92muscle hypertrophy in response to stress (GO:0003299)3.09565644
93cardiac muscle adaptation (GO:0014887)3.09565644
94response to epinephrine (GO:0071871)3.07997183
95regulation of cofactor metabolic process (GO:0051193)3.06966554
96regulation of coenzyme metabolic process (GO:0051196)3.06966554
97positive regulation of heart rate (GO:0010460)3.06498920
98regulation of secondary heart field cardioblast proliferation (GO:0003266)3.06035447
99regulation of cardioblast proliferation (GO:0003264)3.06035447
100striated muscle adaptation (GO:0014888)3.05232475
101cardiac septum development (GO:0003279)3.02256125
102regulation of ATPase activity (GO:0043462)3.01891642
103regulation of ATP catabolic process (GO:1903289)3.01891642
104muscle cell cellular homeostasis (GO:0046716)2.99954490
105carnitine transmembrane transport (GO:1902603)2.99909670
106creatine metabolic process (GO:0006600)2.98490854
107skeletal muscle adaptation (GO:0043501)2.97474002
108myotube cell development (GO:0014904)2.96627374
109regulation of cardiac muscle cell differentiation (GO:2000725)2.96057576
110regulation of muscle system process (GO:0090257)2.95074924
111negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.93903931
112negative regulation of calcium ion transmembrane transport (GO:1903170)2.93903931
113muscle cell development (GO:0055001)2.91837777
114positive regulation of heart contraction (GO:0045823)2.91784553
115regulation of myoblast differentiation (GO:0045661)2.90890088
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89034963
117skeletal muscle tissue development (GO:0007519)2.87796523
118regulation of cardioblast differentiation (GO:0051890)2.87678231
119membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.85803908
120positive regulation of potassium ion transmembrane transport (GO:1901381)2.84495131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse3.77614377
2EZH2_22144423_ChIP-Seq_EOC_Human3.08609534
3VDR_22108803_ChIP-Seq_LS180_Human2.87332437
4* TBX20_22080862_ChIP-Seq_HEART_Mouse2.82012463
5* TBX20_22328084_ChIP-Seq_HEART_Mouse2.82012463
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54311385
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53843514
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51650602
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40228981
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.35395912
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.27473801
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23114192
13MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.19218611
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18811592
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15946602
16TAF15_26573619_Chip-Seq_HEK293_Human2.13441677
17DROSHA_22980978_ChIP-Seq_HELA_Human2.11674119
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99765021
19FUS_26573619_Chip-Seq_HEK293_Human1.99499080
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.96282328
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90445726
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89432666
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.75389852
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75136621
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73293098
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69801536
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69801536
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69508356
29IGF1R_20145208_ChIP-Seq_DFB_Human1.69454729
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.68769224
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67752961
32ZNF263_19887448_ChIP-Seq_K562_Human1.67623029
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67456220
34* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.65955412
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62556753
36* P300_19829295_ChIP-Seq_ESCs_Human1.61187564
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59426779
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58368000
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.58274446
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.56025227
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55549106
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55091881
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53997540
44GBX2_23144817_ChIP-Seq_PC3_Human1.51523222
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51068354
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.51061597
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49695997
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45409295
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.45165177
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44785810
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43671611
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42928303
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40281859
54TCF4_23295773_ChIP-Seq_U87_Human1.39990735
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37244210
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37099223
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36118502
58STAT3_23295773_ChIP-Seq_U87_Human1.35388604
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.34350687
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34283568
61ISL1_27105846_Chip-Seq_CPCs_Mouse1.32542212
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.32362792
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32117605
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31568703
65* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.30905104
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30461378
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30272771
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29326189
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28692098
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28582486
71AHR_22903824_ChIP-Seq_MCF-7_Human1.28197752
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27897221
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26086365
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.26080128
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.25838266
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25252487
77ZNF274_21170338_ChIP-Seq_K562_Hela1.24661439
78RNF2_27304074_Chip-Seq_NSC_Mouse1.23220524
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.22353648
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.22151315
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.22033907
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20755539
83CTCF_27219007_Chip-Seq_Bcells_Human1.20654046
84TP53_16413492_ChIP-PET_HCT116_Human1.19134904
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18462759
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18462759
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18145966
88* SMAD4_21741376_ChIP-Seq_HESCs_Human1.18103651
89SOX2_19829295_ChIP-Seq_ESCs_Human1.17928372
90NANOG_19829295_ChIP-Seq_ESCs_Human1.17928372
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17540388
92EWS_26573619_Chip-Seq_HEK293_Human1.16798196
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16654059
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15601329
95* SMAD4_21799915_ChIP-Seq_A2780_Human1.14036445
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13311109
97AR_25329375_ChIP-Seq_VCAP_Human1.12687094
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12546059
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12477963
100BCAT_22108803_ChIP-Seq_LS180_Human1.12073611
101* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11806300
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11145358
103ER_23166858_ChIP-Seq_MCF-7_Human1.10406248
104TBL1_22424771_ChIP-Seq_293T_Human1.10217946
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.09575076
106KDM2B_26808549_Chip-Seq_K562_Human1.09275325
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09073153
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08831832
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08828660
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08736548
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08343996
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07948456
113CBP_20019798_ChIP-Seq_JUKART_Human1.07948456
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.07518832
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06774143
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06774143
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06471436
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04724740
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04458684
120SOX9_26525672_Chip-Seq_HEART_Mouse1.04106616
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03850269
122WT1_19549856_ChIP-ChIP_CCG9911_Human1.02983163
123AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02652980
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02195513
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02010704
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.01810670
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01663782
128CLOCK_20551151_ChIP-Seq_293T_Human1.01504872
129AR_19668381_ChIP-Seq_PC3_Human1.00418430
130* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99900238
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99766780
132E2F1_18555785_Chip-Seq_ESCs_Mouse0.99670640
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.98786355
134ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98336420
135OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97837250
136* CJUN_26792858_Chip-Seq_BT549_Human0.97345428
137GATA1_19941826_ChIP-Seq_K562_Human0.95147552
138NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94423113
139EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93100779
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92732014
141* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91733609
142TCF4_18268006_ChIP-ChIP_LS174T_Human0.91683759
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91013757
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90319252
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.89460089
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89223181
147FOXA2_19822575_ChIP-Seq_HepG2_Human0.88981784
148ESR1_21235772_ChIP-Seq_MCF-7_Human0.88688336
149AR_21572438_ChIP-Seq_LNCaP_Human0.87509526
150TP53_23651856_ChIP-Seq_MEFs_Mouse0.85966310
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84002495
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83835957
153RING1B_27294783_Chip-Seq_ESCs_Mouse0.83709506
154YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83433745
155TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83338248
156THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82402238
157SMAD_19615063_ChIP-ChIP_OVARY_Human0.81505392
158SMAD3_21741376_ChIP-Seq_EPCs_Human0.81454349
159KDM2B_26808549_Chip-Seq_DND41_Human0.81228681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.30922381
2MP0000751_myopathy5.30654007
3MP0004084_abnormal_cardiac_muscle5.03887938
4MP0003646_muscle_fatigue4.65449802
5MP0004215_abnormal_myocardial_fiber4.28350965
6MP0000749_muscle_degeneration4.20072338
7MP0004036_abnormal_muscle_relaxation4.06436223
8MP0004145_abnormal_muscle_electrophysio3.67923753
9MP0005330_cardiomyopathy3.45657829
10MP0004087_abnormal_muscle_fiber3.04773550
11MP0002972_abnormal_cardiac_muscle2.85479732
12MP0000750_abnormal_muscle_regeneration2.82375147
13MP0005620_abnormal_muscle_contractility2.77341277
14MP0002106_abnormal_muscle_physiology2.67251917
15MP0003137_abnormal_impulse_conducting2.49414245
16MP0008775_abnormal_heart_ventricle2.44943173
17MP0002269_muscular_atrophy2.40631213
18MP0000747_muscle_weakness2.33929525
19MP0010630_abnormal_cardiac_muscle2.27486118
20MP0004130_abnormal_muscle_cell2.24519101
21MP0000759_abnormal_skeletal_muscle2.24194122
22MP0004484_altered_response_of2.23469771
23MP0005369_muscle_phenotype2.23462447
24MP0005385_cardiovascular_system_phenoty2.20388754
25MP0001544_abnormal_cardiovascular_syste2.20388754
26MP0004085_abnormal_heartbeat2.05908457
27MP0006138_congestive_heart_failure1.99314388
28MP0003828_pulmonary_edema1.87368421
29MP0004510_myositis1.84604014
30MP0003950_abnormal_plasma_membrane1.81777615
31MP0002127_abnormal_cardiovascular_syste1.74784552
32MP0004233_abnormal_muscle_weight1.73681360
33MP0009780_abnormal_chondrocyte_physiolo1.66957736
34MP0000013_abnormal_adipose_tissue1.63841969
35MP0003221_abnormal_cardiomyocyte_apopto1.54699992
36MP0010368_abnormal_lymphatic_system1.50330127
37MP0002909_abnormal_adrenal_gland1.38341123
38MP0005670_abnormal_white_adipose1.32965340
39MP0001879_abnormal_lymphatic_vessel1.27241775
40MP0002332_abnormal_exercise_endurance1.27015028
41MP0002108_abnormal_muscle_morphology1.24283188
42MP0003045_fibrosis1.16965956
43MP0006036_abnormal_mitochondrial_physio1.16892278
44MP0003136_yellow_coat_color1.14958871
45MP0005666_abnormal_adipose_tissue1.11992365
46MP0002822_catalepsy1.08778277
47MP0004272_abnormal_basement_membrane1.06915509
48MP0000266_abnormal_heart_morphology1.03667820
49MP0002234_abnormal_pharynx_morphology1.03453229
50MP0000733_abnormal_muscle_development1.02400413
51MP0004270_analgesia0.96208858
52MP0002102_abnormal_ear_morphology0.96106763
53MP0003279_aneurysm0.93581328
54MP0005623_abnormal_meninges_morphology0.93477963
55MP0005375_adipose_tissue_phenotype0.92134258
56MP0000230_abnormal_systemic_arterial0.91277960
57MP0002638_abnormal_pupillary_reflex0.87785261
58MP0003567_abnormal_fetal_cardiomyocyte0.87063094
59MP0000003_abnormal_adipose_tissue0.83718436
60MP0005165_increased_susceptibility_to0.81033596
61MP0004043_abnormal_pH_regulation0.79209477
62MP0004185_abnormal_adipocyte_glucose0.77582708
63MP0001984_abnormal_olfaction0.77351044
64MP0002877_abnormal_melanocyte_morpholog0.75888741
65MP0003283_abnormal_digestive_organ0.74366294
66MP0008961_abnormal_basal_metabolism0.71145887
67MP0002128_abnormal_blood_circulation0.70699549
68MP0003937_abnormal_limbs/digits/tail_de0.67563801
69MP0006292_abnormal_olfactory_placode0.67146839
70MP0002078_abnormal_glucose_homeostasis0.66632085
71MP0000343_altered_response_to0.63864000
72MP0000767_abnormal_smooth_muscle0.63004175
73MP0005187_abnormal_penis_morphology0.61678269
74MP0001485_abnormal_pinna_reflex0.60901941
75MP0005167_abnormal_blood-brain_barrier0.59952631
76MP0004859_abnormal_synaptic_plasticity0.58233796
77MP0009250_abnormal_appendicular_skeleto0.57960274
78MP0010030_abnormal_orbit_morphology0.57626159
79MP0004133_heterotaxia0.56958399
80MP0001270_distended_abdomen0.56912364
81MP0003566_abnormal_cell_adhesion0.55847812
82MP0004142_abnormal_muscle_tone0.55198482
83MP0005266_abnormal_metabolism0.55109235
84MP0005248_abnormal_Harderian_gland0.54967698
85MP0009384_cardiac_valve_regurgitation0.54756964
86MP0000462_abnormal_digestive_system0.53997889
87MP0003119_abnormal_digestive_system0.53662927
88MP0002925_abnormal_cardiovascular_devel0.51418504
89MP0004885_abnormal_endolymph0.51397705
90MP0005253_abnormal_eye_physiology0.51322740
91MP0001486_abnormal_startle_reflex0.50700103
92MP0005646_abnormal_pituitary_gland0.49647335
93MP0003122_maternal_imprinting0.47104206
94MP0000372_irregular_coat_pigmentation0.46721961
95MP0002896_abnormal_bone_mineralization0.43823564
96MP0005595_abnormal_vascular_smooth0.43391306
97MP0002971_abnormal_brown_adipose0.43252379
98MP0001299_abnormal_eye_distance/0.42703669
99MP0002693_abnormal_pancreas_physiology0.41951007
100MP0006072_abnormal_retinal_apoptosis0.41867826
101MP0000049_abnormal_middle_ear0.41801390
102MP0005386_behavior/neurological_phenoty0.41430697
103MP0004924_abnormal_behavior0.41430697
104MP0005551_abnormal_eye_electrophysiolog0.41339633
105MP0003941_abnormal_skin_development0.40682097
106MP0000631_abnormal_neuroendocrine_gland0.39674466
107MP0000026_abnormal_inner_ear0.39370301
108MP0003705_abnormal_hypodermis_morpholog0.38284905
109MP0004147_increased_porphyrin_level0.37788988
110MP0006035_abnormal_mitochondrial_morpho0.37715224
111MP0003385_abnormal_body_wall0.36855021
112MP0005535_abnormal_body_temperature0.36524435
113MP0002272_abnormal_nervous_system0.36506462
114MP0001784_abnormal_fluid_regulation0.35820136
115MP0000534_abnormal_ureter_morphology0.35728291
116MP0001614_abnormal_blood_vessel0.35173748
117MP0003948_abnormal_gas_homeostasis0.34727694
118MP0008569_lethality_at_weaning0.33763056
119MP0000537_abnormal_urethra_morphology0.33399991
120MP0002734_abnormal_mechanical_nocicepti0.32268284
121MP0001293_anophthalmia0.32111969
122MP0008438_abnormal_cutaneous_collagen0.32076056
123MP0002249_abnormal_larynx_morphology0.30560430
124MP0003935_abnormal_craniofacial_develop0.29893518
125MP0001661_extended_life_span0.29177946
126MP0006276_abnormal_autonomic_nervous0.28960325
127MP0001727_abnormal_embryo_implantation0.28913914
128MP0005334_abnormal_fat_pad0.26854002
129MP0004858_abnormal_nervous_system0.26128379
130MP0003953_abnormal_hormone_level0.25600234
131MP0001765_abnormal_ion_homeostasis0.25068219
132MP0002168_other_aberrant_phenotype0.24908784

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.62882324
2Calf muscle hypertrophy (HP:0008981)6.20274927
3Exercise-induced myalgia (HP:0003738)6.09761343
4Muscle fiber splitting (HP:0003555)5.92466725
5Muscle hypertrophy of the lower extremities (HP:0008968)5.83006836
6Ventricular tachycardia (HP:0004756)5.74882776
7Exercise-induced muscle cramps (HP:0003710)5.52446883
8Abnormality of the calf musculature (HP:0001430)5.37452187
9Hyporeflexia of lower limbs (HP:0002600)5.35016941
10Atrial fibrillation (HP:0005110)5.33410394
11Primary atrial arrhythmia (HP:0001692)5.00435651
12Supraventricular tachycardia (HP:0004755)4.79861923
13Supraventricular arrhythmia (HP:0005115)4.72845695
14Abnormality of the left ventricular outflow tract (HP:0011103)4.70769122
15Subaortic stenosis (HP:0001682)4.70769122
16Lipoatrophy (HP:0100578)4.63338046
17Syncope (HP:0001279)4.45759061
18EMG: myopathic abnormalities (HP:0003458)4.44962510
19Myoglobinuria (HP:0002913)4.38000720
20Right ventricular cardiomyopathy (HP:0011663)4.33454264
21Prolonged QT interval (HP:0001657)4.29911099
22Difficulty running (HP:0009046)4.16816926
23Bundle branch block (HP:0011710)4.15051294
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.07902298
25Type 1 muscle fiber predominance (HP:0003803)4.07031094
26Increased connective tissue (HP:0009025)4.06002891
27Muscle fiber inclusion bodies (HP:0100299)4.05368215
28Dilated cardiomyopathy (HP:0001644)3.92422486
29Ventricular arrhythmia (HP:0004308)3.68657633
30Asymmetric septal hypertrophy (HP:0001670)3.62812658
31Myotonia (HP:0002486)3.57976549
32Palpitations (HP:0001962)3.55334568
33Heart block (HP:0012722)3.40764627
34Nemaline bodies (HP:0003798)3.31449524
35Ventricular fibrillation (HP:0001663)3.29230748
36Abnormal atrioventricular conduction (HP:0005150)3.22849293
37Difficulty climbing stairs (HP:0003551)3.21105914
38Atrioventricular block (HP:0001678)3.18928471
39Abnormal EKG (HP:0003115)3.13972525
40Rhabdomyolysis (HP:0003201)3.06858370
41Increased variability in muscle fiber diameter (HP:0003557)3.00978549
42Absent phalangeal crease (HP:0006109)2.87093301
43Abnormality of skeletal muscle fiber size (HP:0012084)2.82601268
44Neck muscle weakness (HP:0000467)2.80154003
45Distal arthrogryposis (HP:0005684)2.68102558
46Mildly elevated creatine phosphokinase (HP:0008180)2.65017851
47Left ventricular hypertrophy (HP:0001712)2.63276612
48Ketoacidosis (HP:0001993)2.62882892
49Hypoglycemic coma (HP:0001325)2.59121681
50Areflexia of lower limbs (HP:0002522)2.52277292
51Hypoplastic ischia (HP:0003175)2.48671118
52Myopathic facies (HP:0002058)2.46392358
53Hyperinsulinemic hypoglycemia (HP:0000825)2.45897316
54EMG: neuropathic changes (HP:0003445)2.45214136
55Gowers sign (HP:0003391)2.44761262
56Muscle stiffness (HP:0003552)2.44390080
57Round ear (HP:0100830)2.39523285
58Rimmed vacuoles (HP:0003805)2.37343713
59Limited hip movement (HP:0008800)2.35950349
60Muscular dystrophy (HP:0003560)2.35783886
61Pheochromocytoma (HP:0002666)2.35094061
62Abnormal finger flexion creases (HP:0006143)2.30108683
63Deformed tarsal bones (HP:0008119)2.28792195
64Abnormality of the foot musculature (HP:0001436)2.28543207
65Distal lower limb muscle weakness (HP:0009053)2.26410121
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.25675277
67Malignant hyperthermia (HP:0002047)2.23995846
68Abnormality of the ischium (HP:0003174)2.22989222
69Distal lower limb amyotrophy (HP:0008944)2.21963111
70Facial diplegia (HP:0001349)2.21179062
71Foot dorsiflexor weakness (HP:0009027)2.20956411
72Limb-girdle muscle atrophy (HP:0003797)2.13010662
73Palmoplantar keratoderma (HP:0000982)2.12931785
74Scapular winging (HP:0003691)2.08686614
75Calcaneovalgus deformity (HP:0001848)2.07195513
76Proximal amyotrophy (HP:0007126)2.06489901
77Large for gestational age (HP:0001520)2.03303236
78Generalized muscle weakness (HP:0003324)2.02896773
79Neuroendocrine neoplasm (HP:0100634)2.02468608
80Fetal akinesia sequence (HP:0001989)2.01568643
81Insulin-resistant diabetes mellitus (HP:0000831)2.00773598
82Testicular atrophy (HP:0000029)2.00531291
83Hyperglycemia (HP:0003074)1.97723445
84Abnormality of the shoulder girdle musculature (HP:0001435)1.96212311
85Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93165557
86Maternal diabetes (HP:0009800)1.92631871
87Hip contracture (HP:0003273)1.88535137
88Fatigable weakness (HP:0003473)1.88350646
89Abnormality of the neuromuscular junction (HP:0003398)1.88350646
90Hamartoma of the eye (HP:0010568)1.87500770
91Sudden cardiac death (HP:0001645)1.87371534
92Ulnar deviation of the wrist (HP:0003049)1.86095165
93Waddling gait (HP:0002515)1.85161374
94Lower limb amyotrophy (HP:0007210)1.84393676
95Congenital malformation of the right heart (HP:0011723)1.82949622
96Double outlet right ventricle (HP:0001719)1.82949622
97Diaphragmatic weakness (HP:0009113)1.81358874
98Spinal rigidity (HP:0003306)1.81130405
99Frequent falls (HP:0002359)1.80732210
100Congestive heart failure (HP:0001635)1.80483856
101Toxemia of pregnancy (HP:0100603)1.76312660
102Weak cry (HP:0001612)1.76269584
103Steppage gait (HP:0003376)1.75585156
104Pancreatic islet-cell hyperplasia (HP:0004510)1.74384879
105Dysmetric saccades (HP:0000641)1.73024727
106Neoplasm of the adrenal gland (HP:0100631)1.72116252
107Hypoglycemic seizures (HP:0002173)1.65960498
108Hyperkalemia (HP:0002153)1.65580804
109Periauricular skin pits (HP:0100277)1.64897434
110Preauricular pit (HP:0004467)1.64897434
111Ragged-red muscle fibers (HP:0003200)1.63909890
112Abnormal mitochondria in muscle tissue (HP:0008316)1.63684382
113Ketosis (HP:0001946)1.62108798
114Lymphangioma (HP:0100764)1.61941220
115Bulbar palsy (HP:0001283)1.61892204
116Acute necrotizing encephalopathy (HP:0006965)1.59106270
117Dicarboxylic aciduria (HP:0003215)1.58212807
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.58212807
119Easy fatigability (HP:0003388)1.56852754
120Hypoplastic heart (HP:0001961)1.56343785
121Popliteal pterygium (HP:0009756)1.55983021
122Ulnar deviation of finger (HP:0009465)1.51209716
123Aplasia of the musculature (HP:0100854)1.48473355
124Respiratory insufficiency due to muscle weakness (HP:0002747)1.47063381
125Bradycardia (HP:0001662)1.46202949
126Nephronophthisis (HP:0000090)1.46130106
127Tubular atrophy (HP:0000092)1.45729995
128Long clavicles (HP:0000890)1.42658137
129Abnormality of the renal cortex (HP:0011035)1.42628899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.91039124
2TTN4.59527979
3PHKG23.66611671
4PHKG13.66611671
5DMPK3.14347805
6LMTK23.06248428
7MYLK3.03342130
8INSRR2.83400983
9MUSK2.79149768
10TIE12.41464151
11PDK42.36685249
12PDK32.36685249
13TRIB32.28305537
14NEK11.95474402
15PRKD31.91318754
16PIK3CA1.90047109
17PKN21.83274506
18ZAK1.66303853
19STK391.64391937
20FRK1.63735504
21EPHB21.57649575
22PINK11.51011224
23PDK21.48071862
24PIK3CG1.45504010
25CDC42BPA1.43627300
26STK241.36867740
27PAK31.23437107
28MARK11.21968545
29PRKD11.20538881
30TNIK1.18109470
31CAMK2D1.15981554
32ROCK11.10120520
33BCKDK1.05799671
34NEK91.02925662
35WNK41.02550504
36RIPK11.00975383
37ILK1.00754585
38MAP3K70.98890738
39PRKAA10.98377928
40BMPR1B0.95381110
41NLK0.92094487
42GRK70.91754652
43MAPK120.89298854
44EPHA40.85889013
45PRKAA20.84566744
46PTK2B0.82748703
47PDGFRA0.82522033
48GRK10.81264544
49NTRK30.79050606
50NME10.78513473
51KDR0.78142484
52MAPKAPK30.72316179
53EPHA30.72263117
54TRPM70.69296399
55STK380.69012770
56LIMK10.68479805
57PRKCH0.68404151
58STK38L0.68062212
59WNK10.67771976
60MAP3K100.67681556
61EPHB10.67507984
62MAP3K30.66675843
63FER0.64366128
64KSR10.63270406
65CAMK40.62213493
66RPS6KA20.60783436
67CAMK2A0.60707554
68MARK20.58211924
69MAP3K50.57716063
70NEK60.56649648
71PKN10.56567304
72PTK60.56004804
73MAP2K30.52371289
74MAPK70.51711003
75CAMK10.51500267
76MAP4K20.51139983
77TGFBR20.50371204
78ADRBK10.50104561
79MAPK130.49797594
80ADRBK20.49552772
81PRKACB0.49279475
82PRKCE0.48348316
83UHMK10.47335123
84KSR20.45780573
85PLK20.45703013
86STK30.45388604
87MAP3K10.44403646
88PRKACA0.43143858
89MAPK150.43133864
90DAPK30.42956812
91PRKACG0.42312878
92WNK30.41815806
93STK110.41452973
94HIPK20.41061097
95CAMK2B0.40965452
96SGK10.40898980
97MAPK40.40363282
98ERBB30.40221657
99SGK4940.40151075
100SGK2230.40151075
101SGK30.39453643
102RET0.39378623
103PNCK0.38839500
104AKT20.38703316
105RPS6KL10.37819601
106RPS6KC10.37819601
107PDPK10.37746286
108AKT30.37002448
109TGFBR10.36780865
110SIK10.36659641
111PRKG20.36018477
112ROCK20.35499142
113BRSK20.35166685
114MAP2K10.33014435
115LATS10.32090702
116SGK20.32007878
117ACVR1B0.31583626
118PRKG10.31416594
119NUAK10.31326049
120RPS6KA30.31320973
121FLT30.30888507
122CAMK2G0.30408479
123MAP3K20.30352614
124CAMK1G0.30321162
125DYRK20.29607513
126PDK10.29531953
127PAK60.29060370
128FGFR20.28615950
129PRKCQ0.28278020
130FGFR10.28178822
131MAP3K40.27198516
132NTRK10.26122817
133MTOR0.25966881
134CCNB10.25892284
135MAP2K40.25660672
136MARK30.24635915
137LATS20.23758536
138DYRK1B0.20769446
139MOS0.20254288
140RPS6KA10.18793065

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.55363487
2Dilated cardiomyopathy_Homo sapiens_hsa054144.06160114
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.98583183
4Cardiac muscle contraction_Homo sapiens_hsa042603.87181208
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.02284838
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.65721596
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.26606682
8Propanoate metabolism_Homo sapiens_hsa006402.07248268
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02409671
10Parkinsons disease_Homo sapiens_hsa050122.01624642
11Fatty acid degradation_Homo sapiens_hsa000711.78480627
12Oxidative phosphorylation_Homo sapiens_hsa001901.71251035
13Viral myocarditis_Homo sapiens_hsa054161.66847252
14Insulin secretion_Homo sapiens_hsa049111.65795474
15Alzheimers disease_Homo sapiens_hsa050101.57041490
16cGMP-PKG signaling pathway_Homo sapiens_hsa040221.53829004
17Carbon metabolism_Homo sapiens_hsa012001.41455777
18Fatty acid metabolism_Homo sapiens_hsa012121.39862062
19Type II diabetes mellitus_Homo sapiens_hsa049301.39433877
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37283585
21Insulin resistance_Homo sapiens_hsa049311.37241656
22Oxytocin signaling pathway_Homo sapiens_hsa049211.36647910
23Glucagon signaling pathway_Homo sapiens_hsa049221.36376877
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27377431
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.23464652
26Calcium signaling pathway_Homo sapiens_hsa040201.19404595
27Insulin signaling pathway_Homo sapiens_hsa049101.18541131
28Focal adhesion_Homo sapiens_hsa045101.18405339
29Circadian entrainment_Homo sapiens_hsa047131.17590701
30Renin secretion_Homo sapiens_hsa049241.14752426
31Huntingtons disease_Homo sapiens_hsa050161.11433661
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.07724862
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05570538
34Pyruvate metabolism_Homo sapiens_hsa006201.04328623
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02666672
36Phototransduction_Homo sapiens_hsa047440.98814509
37Starch and sucrose metabolism_Homo sapiens_hsa005000.98809689
38Nitrogen metabolism_Homo sapiens_hsa009100.97600594
39Tight junction_Homo sapiens_hsa045300.97474555
40Butanoate metabolism_Homo sapiens_hsa006500.97223609
41Adipocytokine signaling pathway_Homo sapiens_hsa049200.95553018
42Arginine and proline metabolism_Homo sapiens_hsa003300.94532171
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94143379
44beta-Alanine metabolism_Homo sapiens_hsa004100.93539911
45Gastric acid secretion_Homo sapiens_hsa049710.91814902
46Circadian rhythm_Homo sapiens_hsa047100.90547251
47Cholinergic synapse_Homo sapiens_hsa047250.89898671
48AMPK signaling pathway_Homo sapiens_hsa041520.89483154
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89372211
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88373937
51cAMP signaling pathway_Homo sapiens_hsa040240.87382150
52Linoleic acid metabolism_Homo sapiens_hsa005910.87372738
53Olfactory transduction_Homo sapiens_hsa047400.85395558
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82626123
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80228310
56Regulation of autophagy_Homo sapiens_hsa041400.79520608
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77585140
58Adherens junction_Homo sapiens_hsa045200.76750007
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75719234
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75451737
61ECM-receptor interaction_Homo sapiens_hsa045120.73792385
62Hippo signaling pathway_Homo sapiens_hsa043900.72617916
63Lysine degradation_Homo sapiens_hsa003100.71600082
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71576464
65GnRH signaling pathway_Homo sapiens_hsa049120.71433803
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70302593
67Cocaine addiction_Homo sapiens_hsa050300.69015629
68Long-term potentiation_Homo sapiens_hsa047200.68982084
69Basal cell carcinoma_Homo sapiens_hsa052170.68593624
70Gap junction_Homo sapiens_hsa045400.67673907
71Arginine biosynthesis_Homo sapiens_hsa002200.67647195
72Amphetamine addiction_Homo sapiens_hsa050310.67327652
73PPAR signaling pathway_Homo sapiens_hsa033200.66466667
74Dorso-ventral axis formation_Homo sapiens_hsa043200.65348608
75HIF-1 signaling pathway_Homo sapiens_hsa040660.63911127
76TGF-beta signaling pathway_Homo sapiens_hsa043500.62703258
77Protein digestion and absorption_Homo sapiens_hsa049740.62546862
78Hedgehog signaling pathway_Homo sapiens_hsa043400.62377972
79Taste transduction_Homo sapiens_hsa047420.61649926
80Dopaminergic synapse_Homo sapiens_hsa047280.61167489
81Morphine addiction_Homo sapiens_hsa050320.59863255
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59374145
83mTOR signaling pathway_Homo sapiens_hsa041500.58965602
84Fatty acid elongation_Homo sapiens_hsa000620.57223754
85Pancreatic secretion_Homo sapiens_hsa049720.54852513
86Ovarian steroidogenesis_Homo sapiens_hsa049130.54813124
87Galactose metabolism_Homo sapiens_hsa000520.54662163
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54017695
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.53950504
90GABAergic synapse_Homo sapiens_hsa047270.53584736
91Salivary secretion_Homo sapiens_hsa049700.53403436
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51747380
93Estrogen signaling pathway_Homo sapiens_hsa049150.51165040
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50459140
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50181315
96Tryptophan metabolism_Homo sapiens_hsa003800.49313633
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47934385
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46424342
99Amoebiasis_Homo sapiens_hsa051460.46393379
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46344130
101ABC transporters_Homo sapiens_hsa020100.45671183
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45431163
103Histidine metabolism_Homo sapiens_hsa003400.44868110
104Peroxisome_Homo sapiens_hsa041460.44661382
105Renal cell carcinoma_Homo sapiens_hsa052110.43621021
106Proteoglycans in cancer_Homo sapiens_hsa052050.43605751
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43376570
108Platelet activation_Homo sapiens_hsa046110.42670474
109Melanogenesis_Homo sapiens_hsa049160.42372945
110Mineral absorption_Homo sapiens_hsa049780.41799064
111RNA degradation_Homo sapiens_hsa030180.40995126
112Selenocompound metabolism_Homo sapiens_hsa004500.40579231
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40386454
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39874219
115VEGF signaling pathway_Homo sapiens_hsa043700.39735372
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.39003912
117Glutamatergic synapse_Homo sapiens_hsa047240.38534164
118Phenylalanine metabolism_Homo sapiens_hsa003600.37370776
119Tyrosine metabolism_Homo sapiens_hsa003500.36861722
120Axon guidance_Homo sapiens_hsa043600.36776864
121MAPK signaling pathway_Homo sapiens_hsa040100.35752562
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34892774
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34745878
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33489450
125Rap1 signaling pathway_Homo sapiens_hsa040150.33007302
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.28266462
127Serotonergic synapse_Homo sapiens_hsa047260.27889942
128FoxO signaling pathway_Homo sapiens_hsa040680.26335224
129Biosynthesis of amino acids_Homo sapiens_hsa012300.26086577
130Bile secretion_Homo sapiens_hsa049760.25989540

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