FIP1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.90112516
2synapsis (GO:0007129)5.68760934
3centriole replication (GO:0007099)4.81291140
4mitotic sister chromatid cohesion (GO:0007064)4.74580446
5DNA unwinding involved in DNA replication (GO:0006268)4.70384580
6protein localization to kinetochore (GO:0034501)4.52417370
7regulation of DNA endoreduplication (GO:0032875)4.45969756
8chromosome organization involved in meiosis (GO:0070192)4.36351041
9male meiosis I (GO:0007141)4.32908131
10mitotic chromosome condensation (GO:0007076)4.30550915
11nuclear pore complex assembly (GO:0051292)4.29194552
12DNA methylation involved in gamete generation (GO:0043046)4.27733180
13microtubule depolymerization (GO:0007019)4.22003088
14DNA synthesis involved in DNA repair (GO:0000731)4.18496785
15regulation of meiosis I (GO:0060631)4.08293475
16male meiosis (GO:0007140)4.04259595
17nuclear pore organization (GO:0006999)4.00401850
18protein localization to chromosome, centromeric region (GO:0071459)3.99267465
19pre-miRNA processing (GO:0031054)3.98407969
20sister chromatid segregation (GO:0000819)3.92340096
21meiosis I (GO:0007127)3.80239862
22meiotic nuclear division (GO:0007126)3.76224079
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.69172716
24centriole assembly (GO:0098534)3.68996601
25negative regulation of histone methylation (GO:0031061)3.65844178
26mitotic sister chromatid segregation (GO:0000070)3.65481391
27mitotic nuclear envelope disassembly (GO:0007077)3.64723890
28histone exchange (GO:0043486)3.64175167
29regulation of RNA export from nucleus (GO:0046831)3.61806609
30resolution of meiotic recombination intermediates (GO:0000712)3.60987772
31kinetochore organization (GO:0051383)3.54718346
32mitotic metaphase plate congression (GO:0007080)3.54517873
33membrane disassembly (GO:0030397)3.48032084
34nuclear envelope disassembly (GO:0051081)3.48032084
35regulation of centriole replication (GO:0046599)3.46884339
36synaptonemal complex assembly (GO:0007130)3.46753808
37regulation of spindle organization (GO:0090224)3.43310456
38single strand break repair (GO:0000012)3.41354698
39DNA duplex unwinding (GO:0032508)3.38182249
40meiotic cell cycle process (GO:1903046)3.34413290
41DNA geometric change (GO:0032392)3.34364614
42protein localization to chromosome (GO:0034502)3.33224503
43regulation of sister chromatid cohesion (GO:0007063)3.32804917
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31071808
45metaphase plate congression (GO:0051310)3.30461889
46folic acid-containing compound biosynthetic process (GO:0009396)3.27936794
47proteasome assembly (GO:0043248)3.27486473
48DNA packaging (GO:0006323)3.20416247
49negative regulation of RNA splicing (GO:0033119)3.18020276
50synaptonemal complex organization (GO:0070193)3.17622823
51regulation of mitotic spindle organization (GO:0060236)3.16935484
52attachment of spindle microtubules to kinetochore (GO:0008608)3.14999908
53pore complex assembly (GO:0046931)3.13012840
54regulation of histone H3-K9 methylation (GO:0051570)3.11677106
55heterochromatin organization (GO:0070828)3.11137088
56ribosomal large subunit biogenesis (GO:0042273)3.10750870
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10633756
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10633756
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.10633756
60histone mRNA metabolic process (GO:0008334)3.05688541
61positive regulation of chromosome segregation (GO:0051984)3.05631843
62DNA replication-dependent nucleosome assembly (GO:0006335)3.05303097
63DNA replication-dependent nucleosome organization (GO:0034723)3.05303097
64reciprocal meiotic recombination (GO:0007131)3.04231483
65reciprocal DNA recombination (GO:0035825)3.04231483
66ribosome biogenesis (GO:0042254)3.00615059
67meiotic cell cycle (GO:0051321)3.00487838
68establishment of chromosome localization (GO:0051303)3.00326533
69meiotic chromosome segregation (GO:0045132)2.99431724
70positive regulation of histone H3-K4 methylation (GO:0051571)2.97680237
71gene silencing by RNA (GO:0031047)2.97024858
72chromatin assembly or disassembly (GO:0006333)2.96617480
73alternative mRNA splicing, via spliceosome (GO:0000380)2.96410385
74negative regulation of mRNA processing (GO:0050686)2.95489117
75RNA stabilization (GO:0043489)2.95005096
76mRNA stabilization (GO:0048255)2.95005096
77glucocorticoid receptor signaling pathway (GO:0042921)2.94936691
78dosage compensation (GO:0007549)2.94842086
79protein K6-linked ubiquitination (GO:0085020)2.93185861
80DNA topological change (GO:0006265)2.91841729
81ribonucleoprotein complex biogenesis (GO:0022613)2.90724839
82rRNA methylation (GO:0031167)2.89417594
83maturation of SSU-rRNA (GO:0030490)2.89230264
84chromatin assembly (GO:0031497)2.89061779
85nuclear envelope organization (GO:0006998)2.87710484
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86637723
87spindle assembly checkpoint (GO:0071173)2.86466738
88kinetochore assembly (GO:0051382)2.86107345
89termination of RNA polymerase II transcription (GO:0006369)2.86100076
90spindle checkpoint (GO:0031577)2.85806230
91establishment of integrated proviral latency (GO:0075713)2.85694752
92positive regulation of histone methylation (GO:0031062)2.83839485
93nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.82721271
94negative regulation of mRNA metabolic process (GO:1903312)2.82647410
95mitotic spindle assembly checkpoint (GO:0007094)2.82027454
96regulation of chromosome segregation (GO:0051983)2.81903017
97binding of sperm to zona pellucida (GO:0007339)2.81616272
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81267243
99formation of translation preinitiation complex (GO:0001731)2.81115105
100DNA conformation change (GO:0071103)2.80875424
101negative regulation of chromosome segregation (GO:0051985)2.80548941
102rRNA modification (GO:0000154)2.79995856
103regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79859376
104DNA replication checkpoint (GO:0000076)2.79663473
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79308452
106microtubule nucleation (GO:0007020)2.78277138
107DNA replication-independent nucleosome assembly (GO:0006336)2.77904392
108DNA replication-independent nucleosome organization (GO:0034724)2.77904392
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77414601
110negative regulation of sister chromatid segregation (GO:0033046)2.77414601
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.77414601
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77414601
113regulation of nucleobase-containing compound transport (GO:0032239)2.77318910
114ATP-dependent chromatin remodeling (GO:0043044)2.77185324
115histone H2A monoubiquitination (GO:0035518)2.76316799
116microtubule polymerization or depolymerization (GO:0031109)2.75121982
117ribosomal small subunit assembly (GO:0000028)2.75024111
118mitotic spindle checkpoint (GO:0071174)2.74308326
119regulation of DNA damage checkpoint (GO:2000001)2.74268998
120non-recombinational repair (GO:0000726)2.73979766
121double-strand break repair via nonhomologous end joining (GO:0006303)2.73979766
122histone mRNA catabolic process (GO:0071044)2.71787310
123regulation of mitotic sister chromatid separation (GO:0010965)2.70027235
124regulation of mitotic sister chromatid segregation (GO:0033047)2.70027235
125regulation of sister chromatid segregation (GO:0033045)2.70027235
126DNA replication initiation (GO:0006270)2.68014564
127DNA strand elongation involved in DNA replication (GO:0006271)2.66793546
128chromosome segregation (GO:0007059)2.66390857
129RNA splicing, via transesterification reactions (GO:0000375)2.65587285
130RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.65464084
131mRNA splicing, via spliceosome (GO:0000398)2.65464084
132regulation of histone H3-K4 methylation (GO:0051569)2.65386860
133regulation of translational fidelity (GO:0006450)2.63200401
134chromosome condensation (GO:0030261)2.61271630
135sister chromatid cohesion (GO:0007062)2.61125374
136cytoplasmic mRNA processing body assembly (GO:0033962)2.58704408
137snRNA processing (GO:0016180)2.58249807
138mRNA transport (GO:0051028)2.57352797
139translesion synthesis (GO:0019985)2.57086343
140chromatin remodeling at centromere (GO:0031055)2.56263898
141CENP-A containing nucleosome assembly (GO:0034080)2.54907822
142regulation of centrosome cycle (GO:0046605)2.54294480
143gene silencing (GO:0016458)2.53936303
144DNA strand elongation (GO:0022616)2.53297943
145snRNA metabolic process (GO:0016073)2.51822570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.40815633
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.01791271
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.20390589
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.66351997
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.63577747
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.27092248
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.20138214
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.10428170
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.07144913
10MYC_22102868_ChIP-Seq_BL_Human2.91675543
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55702628
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.52044162
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51392132
14AR_21909140_ChIP-Seq_LNCAP_Human2.38892785
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21161618
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20426570
17CIITA_25753668_ChIP-Seq_RAJI_Human2.19580836
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13916647
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13066335
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11694662
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11434585
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.04349979
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01122861
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.92574053
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88914600
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88637650
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.83755863
28XRN2_22483619_ChIP-Seq_HELA_Human1.83252736
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79375333
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79324177
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79062935
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79028923
33CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.73999315
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72718556
35IRF1_19129219_ChIP-ChIP_H3396_Human1.64372186
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64347693
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60584652
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58850457
39KDM5A_27292631_Chip-Seq_BREAST_Human1.54867103
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53340102
41TTF2_22483619_ChIP-Seq_HELA_Human1.52881442
42* MYC_18940864_ChIP-ChIP_HL60_Human1.51578506
43FOXP3_21729870_ChIP-Seq_TREG_Human1.51419126
44VDR_23849224_ChIP-Seq_CD4+_Human1.51254162
45ELK1_19687146_ChIP-ChIP_HELA_Human1.49118979
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.48002588
47* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47314276
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47147050
49FUS_26573619_Chip-Seq_HEK293_Human1.43942627
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43033353
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.42660283
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.41274507
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39745752
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39412279
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38553507
56VDR_21846776_ChIP-Seq_THP-1_Human1.37174308
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.37171828
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37005448
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36558659
60* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.36472848
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35784825
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.35169490
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34536304
64ZNF274_21170338_ChIP-Seq_K562_Hela1.33552805
65TFEB_21752829_ChIP-Seq_HELA_Human1.33339421
66* GABP_19822575_ChIP-Seq_HepG2_Human1.32781052
67FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31148602
68* EWS_26573619_Chip-Seq_HEK293_Human1.30350468
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28821220
70CHD1_26751641_Chip-Seq_LNCaP_Human1.27391556
71* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24957080
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24567118
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23916196
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23740790
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22794558
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21626709
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21308230
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20498211
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20312654
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19961970
81TCF7_22412390_ChIP-Seq_EML_Mouse1.19678109
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19644090
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19034178
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18303266
85IGF1R_20145208_ChIP-Seq_DFB_Human1.17790052
86* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17630514
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.16432725
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14942343
89EZH2_22144423_ChIP-Seq_EOC_Human1.13478731
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11138456
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10465183
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.10265791
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10253471
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08648186
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08097569
96DCP1A_22483619_ChIP-Seq_HELA_Human1.06830254
97UTX_26944678_Chip-Seq_JUKART_Human1.06525359
98* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06503442
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03874509
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03327552
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02930062
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01798448
103E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98060494
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95581519
105* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94423695
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94175892
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94076958
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93800445
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93427721
110THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92109863
111KDM2B_26808549_Chip-Seq_DND41_Human0.91372133
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91035513
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90023392
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89619263
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89083823
116* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88981654
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88938732
118TAF15_26573619_Chip-Seq_HEK293_Human0.87815527
119MYB_26560356_Chip-Seq_TH1_Human0.87249232
120BRD4_25478319_ChIP-Seq_HGPS_Human0.83284489
121* SOX2_16153702_ChIP-ChIP_HESCs_Human0.82330761
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.81928982
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81837815
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81670579
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79637865
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79435697
127VDR_22108803_ChIP-Seq_LS180_Human0.77925385
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77571545
129CBP_20019798_ChIP-Seq_JUKART_Human0.77571545
130MYB_26560356_Chip-Seq_TH2_Human0.77547276
131TP53_22573176_ChIP-Seq_HFKS_Human0.76748872
132ER_23166858_ChIP-Seq_MCF-7_Human0.74502421
133* SOX17_20123909_ChIP-Seq_XEN_Mouse0.69977226
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.67401699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.33488474
2MP0003693_abnormal_embryo_hatching3.15069020
3MP0003111_abnormal_nucleus_morphology3.04983904
4MP0004957_abnormal_blastocyst_morpholog2.88491452
5MP0003077_abnormal_cell_cycle2.80871193
6MP0003718_maternal_effect2.68891645
7MP0008057_abnormal_DNA_replication2.63849120
8MP0008995_early_reproductive_senescence2.57365170
9MP0003121_genomic_imprinting2.57302781
10MP0003123_paternal_imprinting2.57270208
11MP0001929_abnormal_gametogenesis2.52449902
12MP0008007_abnormal_cellular_replicative2.36309827
13MP0010352_gastrointestinal_tract_polyps2.28594821
14MP0005076_abnormal_cell_differentiation2.26139546
15MP0000537_abnormal_urethra_morphology2.21415822
16MP0008877_abnormal_DNA_methylation2.15031303
17MP0006035_abnormal_mitochondrial_morpho2.09911612
18MP0003787_abnormal_imprinting2.06938687
19MP0003786_premature_aging2.04532753
20MP0003698_abnormal_male_reproductive2.03972581
21MP0010030_abnormal_orbit_morphology2.02634157
22MP0000350_abnormal_cell_proliferation1.97760669
23MP0001730_embryonic_growth_arrest1.96766576
24MP0002084_abnormal_developmental_patter1.85282341
25MP0005410_abnormal_fertilization1.74994659
26MP0002877_abnormal_melanocyte_morpholog1.73972493
27MP0002085_abnormal_embryonic_tissue1.70692968
28MP0002102_abnormal_ear_morphology1.70538864
29MP0000428_abnormal_craniofacial_morphol1.70423212
30MP0001697_abnormal_embryo_size1.69566974
31MP0004197_abnormal_fetal_growth/weight/1.69042729
32MP0003890_abnormal_embryonic-extraembry1.67989881
33MP0001672_abnormal_embryogenesis/_devel1.66345588
34MP0005380_embryogenesis_phenotype1.66345588
35MP0008058_abnormal_DNA_repair1.66131843
36MP0000569_abnormal_digit_pigmentation1.65817500
37MP0010307_abnormal_tumor_latency1.60587438
38MP0002396_abnormal_hematopoietic_system1.60339690
39MP0004808_abnormal_hematopoietic_stem1.58468922
40MP0008932_abnormal_embryonic_tissue1.57902203
41MP0001293_anophthalmia1.56753406
42MP0003119_abnormal_digestive_system1.53286393
43MP0004264_abnormal_extraembryonic_tissu1.52760941
44MP0003984_embryonic_growth_retardation1.52261494
45MP0003937_abnormal_limbs/digits/tail_de1.52153425
46MP0002088_abnormal_embryonic_growth/wei1.49451778
47MP0009697_abnormal_copulation1.42112239
48MP0002086_abnormal_extraembryonic_tissu1.41965991
49MP0008789_abnormal_olfactory_epithelium1.40559315
50MP0009703_decreased_birth_body1.37740789
51MP0000015_abnormal_ear_pigmentation1.37708618
52MP0003935_abnormal_craniofacial_develop1.37090219
53MP0002080_prenatal_lethality1.35424781
54MP0002161_abnormal_fertility/fecundity1.33286740
55MP0009672_abnormal_birth_weight1.33148535
56MP0003122_maternal_imprinting1.32843881
57MP0009053_abnormal_anal_canal1.30670428
58MP0000733_abnormal_muscle_development1.26783920
59MP0006072_abnormal_retinal_apoptosis1.26552699
60MP0002653_abnormal_ependyma_morphology1.25532833
61MP0003942_abnormal_urinary_system1.24296486
62MP0002095_abnormal_skin_pigmentation1.22215245
63MP0006054_spinal_hemorrhage1.21737925
64MP0003941_abnormal_skin_development1.20918113
65MP0001849_ear_inflammation1.18994667
66MP0002932_abnormal_joint_morphology1.18511836
67MP0006292_abnormal_olfactory_placode1.17809794
68MP0000358_abnormal_cell_content/1.17028819
69MP0003567_abnormal_fetal_cardiomyocyte1.16371370
70MP0000703_abnormal_thymus_morphology1.15626095
71MP0005394_taste/olfaction_phenotype1.15358031
72MP0005499_abnormal_olfactory_system1.15358031
73MP0003283_abnormal_digestive_organ1.15339368
74MP0003763_abnormal_thymus_physiology1.15195541
75MP0000432_abnormal_head_morphology1.12063994
76MP0000313_abnormal_cell_death1.08793627
77MP0002160_abnormal_reproductive_system1.08365998
78MP0002697_abnormal_eye_size1.08137601
79MP0001286_abnormal_eye_development1.08080194
80MP0002092_abnormal_eye_morphology1.06848529
81MP0000490_abnormal_crypts_of1.05946827
82MP0003755_abnormal_palate_morphology1.04564656
83MP0003115_abnormal_respiratory_system1.03577781
84MP0003699_abnormal_female_reproductive1.02850227
85MP0000372_irregular_coat_pigmentation1.02774433
86MP0005389_reproductive_system_phenotype1.01889749
87MP0000049_abnormal_middle_ear1.00798827
88MP0002116_abnormal_craniofacial_bone1.00739202
89MP0005174_abnormal_tail_pigmentation1.00582400
90MP0001915_intracranial_hemorrhage0.99695071
91MP0003300_gastrointestinal_ulcer0.98922326
92MP0000631_abnormal_neuroendocrine_gland0.98715743
93MP0003705_abnormal_hypodermis_morpholog0.97797312
94MP0004147_increased_porphyrin_level0.96143411
95MP0002938_white_spotting0.95186861
96MP0003186_abnormal_redox_activity0.94747230
97MP0009278_abnormal_bone_marrow0.93701368
98MP0002019_abnormal_tumor_incidence0.93167982
99MP0002111_abnormal_tail_morphology0.92360794
100MP0003385_abnormal_body_wall0.91944985
101MP0003646_muscle_fatigue0.91933936
102MP0005257_abnormal_intraocular_pressure0.91536037
103MP0002925_abnormal_cardiovascular_devel0.91265674
104MP0000678_abnormal_parathyroid_gland0.90925344
105MP0003861_abnormal_nervous_system0.90818249
106MP0001299_abnormal_eye_distance/0.88053537
107MP0001984_abnormal_olfaction0.87923833
108MP0002114_abnormal_axial_skeleton0.87655160
109MP0000534_abnormal_ureter_morphology0.86425682
110MP0008961_abnormal_basal_metabolism0.85635132
111MP0002210_abnormal_sex_determination0.85458621
112MP0004142_abnormal_muscle_tone0.84138271
113MP0005220_abnormal_exocrine_pancreas0.84059337
114MP0006036_abnormal_mitochondrial_physio0.83647877
115MP0001944_abnormal_pancreas_morphology0.82953791
116MP0004233_abnormal_muscle_weight0.81013023
117MP0001919_abnormal_reproductive_system0.80305877
118MP0000647_abnormal_sebaceous_gland0.79364363
119MP0005248_abnormal_Harderian_gland0.77723418
120MP0005075_abnormal_melanosome_morpholog0.77433420
121MP0003943_abnormal_hepatobiliary_system0.77235137
122MP0000003_abnormal_adipose_tissue0.77009757
123MP0004742_abnormal_vestibular_system0.76094242
124MP0005621_abnormal_cell_physiology0.74599406
125MP0002177_abnormal_outer_ear0.74173837
126MP0005384_cellular_phenotype0.73976609
127MP0002233_abnormal_nose_morphology0.73491399
128MP0000653_abnormal_sex_gland0.73077447
129MP0002109_abnormal_limb_morphology0.72850303
130MP0009384_cardiac_valve_regurgitation0.72609964
131MP0002234_abnormal_pharynx_morphology0.72555736
132MP0005391_vision/eye_phenotype0.72393195
133MP0001119_abnormal_female_reproductive0.72350641
134MP0005395_other_phenotype0.72210038
135MP0001145_abnormal_male_reproductive0.70868555
136MP0000427_abnormal_hair_cycle0.70636691
137MP0005408_hypopigmentation0.69640766
138MP0000778_abnormal_nervous_system0.69365054
139MP0001529_abnormal_vocalization0.69054555
140MP0003936_abnormal_reproductive_system0.67299472
141MP0005253_abnormal_eye_physiology0.67011422
142MP0002163_abnormal_gland_morphology0.64087432
143MP0001188_hyperpigmentation0.57410466

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.45462737
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.79777029
3Oligodactyly (hands) (HP:0001180)3.64260512
4Abnormality of DNA repair (HP:0003254)3.43763445
5Entropion (HP:0000621)3.24788520
6Abnormality of the fingertips (HP:0001211)3.19361068
7Increased nuchal translucency (HP:0010880)3.06433459
8Reticulocytopenia (HP:0001896)2.94204031
9Oligodactyly (HP:0012165)2.90601354
10Aplasia/Hypoplasia of the sternum (HP:0006714)2.87317040
11Ependymoma (HP:0002888)2.82454542
12Short 4th metacarpal (HP:0010044)2.79392420
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.79392420
14Long eyelashes (HP:0000527)2.78949894
15Proximal placement of thumb (HP:0009623)2.74960122
16Deviation of the thumb (HP:0009603)2.73382772
17Abnormality of cells of the erythroid lineage (HP:0012130)2.71322129
18Medulloblastoma (HP:0002885)2.67758955
19High anterior hairline (HP:0009890)2.66131043
20Poikiloderma (HP:0001029)2.63586199
21Gonadotropin excess (HP:0000837)2.57284099
22Colon cancer (HP:0003003)2.51749216
23Abnormality of the astrocytes (HP:0100707)2.47780611
24Astrocytoma (HP:0009592)2.47780611
25Rhabdomyosarcoma (HP:0002859)2.45879368
26Degeneration of anterior horn cells (HP:0002398)2.43660765
27Abnormality of the anterior horn cell (HP:0006802)2.43660765
28Rib fusion (HP:0000902)2.43032148
29Nephrogenic diabetes insipidus (HP:0009806)2.39973876
30Truncal obesity (HP:0001956)2.37709015
31Papillary thyroid carcinoma (HP:0002895)2.34888601
32Duodenal stenosis (HP:0100867)2.34276271
33Small intestinal stenosis (HP:0012848)2.34276271
34Broad thumb (HP:0011304)2.28856168
35Nephronophthisis (HP:0000090)2.28755550
36Abnormality of the renal medulla (HP:0100957)2.27936803
37Short 1st metacarpal (HP:0010034)2.27039705
38Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.27039705
39Abnormal number of erythroid precursors (HP:0012131)2.24991125
40Birth length less than 3rd percentile (HP:0003561)2.22696426
41Hypoplastic iliac wings (HP:0002866)2.22567394
4211 pairs of ribs (HP:0000878)2.21505882
43Meckel diverticulum (HP:0002245)2.20983453
44Glioma (HP:0009733)2.19760223
45Embryonal renal neoplasm (HP:0011794)2.18848757
46Dislocated radial head (HP:0003083)2.17648969
47Neoplasm of striated muscle (HP:0009728)2.15334422
48Gastrointestinal carcinoma (HP:0002672)2.15187654
49Malignant gastrointestinal tract tumors (HP:0006749)2.15187654
50Cerebral hypomyelination (HP:0006808)2.14319224
51Neoplasm of the oral cavity (HP:0100649)2.14190287
52Selective tooth agenesis (HP:0001592)2.13731609
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.13446624
54Abnormality of the ileum (HP:0001549)2.13377241
55Sloping forehead (HP:0000340)2.13127428
56Abdominal situs inversus (HP:0003363)2.13061599
57Abnormality of abdominal situs (HP:0011620)2.13061599
58Tubulointerstitial nephritis (HP:0001970)2.11944404
59Cortical dysplasia (HP:0002539)2.10849095
60Medial flaring of the eyebrow (HP:0010747)2.10469614
61Broad phalanges of the hand (HP:0009768)2.10077705
62Patellar aplasia (HP:0006443)2.09296458
63Abnormality of the nasal septum (HP:0000419)2.08386079
64Renal duplication (HP:0000075)2.08351381
65Premature ovarian failure (HP:0008209)2.07766662
66Sparse lateral eyebrow (HP:0005338)2.07288379
67Macroorchidism (HP:0000053)2.07236965
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07149395
69Facial hemangioma (HP:0000329)2.06888437
70Shawl scrotum (HP:0000049)2.06521610
71Chronic hepatic failure (HP:0100626)2.06488600
72Abnormality of the radial head (HP:0003995)2.05511310
73Aplasia/Hypoplasia of the patella (HP:0006498)2.05378745
74Atresia of the external auditory canal (HP:0000413)2.05120636
75Biliary tract neoplasm (HP:0100574)2.04868101
76Horseshoe kidney (HP:0000085)2.04124851
77Broad palm (HP:0001169)2.03185791
78Abnormality of the proximal phalanges of the hand (HP:0009834)2.02621273
79Abnormal spermatogenesis (HP:0008669)2.01631004
80Hip dysplasia (HP:0001385)2.01551798
81Macrocytic anemia (HP:0001972)2.00618286
82Increased hepatocellular lipid droplets (HP:0006565)2.00496024
83Median cleft lip (HP:0000161)1.98464028
84Overlapping toe (HP:0001845)1.95828631
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94544412
86Degeneration of the lateral corticospinal tracts (HP:0002314)1.94544412
87Hypoplastic labia majora (HP:0000059)1.94390584
88Broad finger (HP:0001500)1.92562305
89Abnormality of the 4th metacarpal (HP:0010012)1.92378218
90Congenital primary aphakia (HP:0007707)1.90821497
91Molar tooth sign on MRI (HP:0002419)1.90314932
92Abnormality of midbrain morphology (HP:0002418)1.90314932
93Abnormality of the preputium (HP:0100587)1.90096147
94Prominent nose (HP:0000448)1.89820292
95Deep philtrum (HP:0002002)1.89263128
96Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.89097304
97Abnormality of the duodenum (HP:0002246)1.89015196
98Upper limb muscle weakness (HP:0003484)1.88786150
99Abnormal hair whorl (HP:0010721)1.88591033
100Shallow orbits (HP:0000586)1.87679474
101Abnormality of the septum pellucidum (HP:0007375)1.87310446
102Abnormality of the labia minora (HP:0012880)1.86146443
103Abnormality of the 1st metacarpal (HP:0010009)1.84794469
104Absent thumb (HP:0009777)1.84538107
105Abnormality of the metopic suture (HP:0005556)1.83848893
106Abnormal number of incisors (HP:0011064)1.83682255
107Septo-optic dysplasia (HP:0100842)1.83051921
108Short phalanx of the thumb (HP:0009660)1.82735561
109Broad phalanx (HP:0006009)1.82583299
110Poor coordination (HP:0002370)1.81963902
111Hyperacusis (HP:0010780)1.81612176
112Cutis marmorata (HP:0000965)1.80854545
113CNS hypomyelination (HP:0003429)1.80442830
114Ectopic kidney (HP:0000086)1.80260660
115Transitional cell carcinoma of the bladder (HP:0006740)1.79341330
116Abnormality of the labia majora (HP:0012881)1.79257100
117Supernumerary spleens (HP:0009799)1.78580044
118Lipid accumulation in hepatocytes (HP:0006561)1.77186992
119Leiomyosarcoma (HP:0100243)1.76872175
120Uterine leiomyosarcoma (HP:0002891)1.76872175
121Abnormality of the carotid arteries (HP:0005344)1.76687627
122Hypoplasia of the maxilla (HP:0000327)1.76523951
123Acute encephalopathy (HP:0006846)1.76481058
124Short humerus (HP:0005792)1.76416360
125Basal cell carcinoma (HP:0002671)1.76147547
126Missing ribs (HP:0000921)1.75653209
127Obsessive-compulsive behavior (HP:0000722)1.74837831
128Aplasia/hypoplasia of the humerus (HP:0006507)1.74760223
129Growth hormone deficiency (HP:0000824)1.74621296
130Abnormality of the renal cortex (HP:0011035)1.73943505
131Acute necrotizing encephalopathy (HP:0006965)1.73331933
132Lip pit (HP:0100267)1.73269100
133Broad long bones (HP:0005622)1.72940974
134Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72335884
135Narrow palate (HP:0000189)1.72218408
136Heterotopia (HP:0002282)1.72200089
137Cafe-au-lait spot (HP:0000957)1.72185989
138Osteomalacia (HP:0002749)1.72133336
139Gait imbalance (HP:0002141)1.72117106
140Thyroid carcinoma (HP:0002890)1.71549049
141Long clavicles (HP:0000890)1.71471586
142Uterine neoplasm (HP:0010784)1.71324325
143Trigonocephaly (HP:0000243)1.71139495
144Supernumerary ribs (HP:0005815)1.70997904
145Low anterior hairline (HP:0000294)1.70366383
146Optic nerve hypoplasia (HP:0000609)1.69126058
147Vertebral arch anomaly (HP:0008438)1.68172112
148Small hand (HP:0200055)1.67411174
149Prominent nasal bridge (HP:0000426)1.67255112
150Abnormal lung lobation (HP:0002101)1.67183871
151Nephroblastoma (Wilms tumor) (HP:0002667)1.66939893
152Myelodysplasia (HP:0002863)1.66299413
153Morphological abnormality of the inner ear (HP:0011390)1.64630112
154Highly arched eyebrow (HP:0002553)1.64614307
155Abnormality of chromosome stability (HP:0003220)1.64565697
156Oculomotor apraxia (HP:0000657)1.64379091
157Skin tags (HP:0010609)1.64179682
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64052631
159Bladder carcinoma (HP:0002862)1.63626737
160Bladder neoplasm (HP:0009725)1.63626737
161Shoulder girdle muscle weakness (HP:0003547)1.63548825
162Spinal muscular atrophy (HP:0007269)1.63237929
163Chromsome breakage (HP:0040012)1.62674801
164Subacute progressive viral hepatitis (HP:0006572)1.62627691
165Neoplasm of the colon (HP:0100273)1.62184677
166Acute myeloid leukemia (HP:0004808)1.62103856
167Broad toe (HP:0001837)1.61514980
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.61476313
169Abnormality of chromosome segregation (HP:0002916)1.61412497
170Absent septum pellucidum (HP:0001331)1.60911728
171Rectal prolapse (HP:0002035)1.60165660
172Type I transferrin isoform profile (HP:0003642)1.59933766
173Impulsivity (HP:0100710)1.59167078
174Prominent metopic ridge (HP:0005487)1.58993294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.62270411
2CDK124.47943113
3PNCK3.90183422
4EEF2K2.93335896
5PASK2.77131709
6NEK22.75996128
7MAP3K102.60534384
8BRD42.58468859
9CDK192.26807512
10STK102.23125221
11TTK2.12934880
12EIF2AK12.08423511
13LATS11.95543773
14STK161.92347473
15EIF2AK31.84428877
16MST41.81931316
17RPS6KA41.81095665
18ACVR1B1.70506385
19CHEK21.70057637
20ATR1.69474871
21SCYL21.65098851
22SRPK11.57037333
23BRSK21.53115351
24PLK11.52344511
25BUB11.49170501
26CDK61.46641972
27AURKB1.46274152
28CHEK11.46109446
29CDK41.45067771
30MKNK11.39838928
31CDK71.38849390
32PBK1.35196408
33PLK41.33645357
34PLK31.32445610
35ATM1.29898032
36HIPK21.29769510
37WNK11.28818156
38PDGFRA1.28038461
39RPS6KB21.27764647
40DYRK31.26017124
41WEE11.20669363
42ZAK1.20554317
43PKN21.19534473
44MTOR1.18950070
45CDK31.17566357
46TNIK1.17457124
47MAP3K81.16344900
48PLK21.15207173
49STK391.15065297
50TAOK31.15051919
51MAP3K41.14640152
52TSSK61.14193754
53CDK21.13629227
54CDK91.13161840
55MELK1.09058271
56BCR1.06146474
57TGFBR11.04180835
58WNK41.03196317
59TRIB31.00996918
60STK31.00045857
61PTK60.99584644
62STK240.98973546
63NEK10.98882571
64ALK0.95846706
65FLT30.92776220
66BCKDK0.89237086
67VRK10.89043793
68NEK90.88973427
69LRRK20.88795618
70CAMK1D0.88198680
71* CDK10.87470590
72MAP4K10.86699985
73STK40.86419857
74TLK10.84426847
75BRAF0.83758629
76MKNK20.82982220
77CDK80.82959143
78FGFR10.81310023
79NME10.80944271
80BRSK10.79836516
81TESK20.79020177
82OXSR10.78662637
83ITK0.75531538
84AURKA0.72557412
85TEC0.72315333
86NUAK10.72283929
87DYRK1B0.71428312
88TAOK10.70413338
89DMPK0.69705886
90CCNB10.69182261
91FRK0.68367240
92PRKDC0.68084764
93CSNK1E0.67362166
94PAK20.67215441
95BMX0.66986365
96FGFR30.66594443
97PIK3CG0.66416763
98* MAPK140.66174678
99CAMK1G0.65877961
100PDGFRB0.65631127
101PAK40.65304357
102EPHA30.63994893
103TRIM280.61857756
104PDK20.61548260
105PTK2B0.59402559
106PRKD20.58675273
107PIM10.58251426
108CLK10.57661247
109BMPR1B0.56358679
110PRKD30.54971702
111AKT10.54854145
112MAPK100.53479587
113CHUK0.53328332
114MAP3K20.51304940
115NEK60.50727016
116GSK3B0.50435040
117RPS6KA50.49966644
118AKT30.48528920
119NLK0.48053831
120LATS20.47700048
121MAP4K20.47579208
122MAPK10.45473802
123CSNK2A10.45083372
124MAP3K50.45011662
125TYRO30.44742857
126CSNK1A1L0.44459290
127CSNK1G20.44020874
128CSNK1G30.43476907
129CSNK1D0.43385457
130PTK20.43048363
131STK38L0.41964717
132CSNK2A20.41898100
133MAPK90.41540987
134MAP2K70.40900315
135MARK20.40799778
136MAP3K90.39362287
137MATK0.39173800
138KSR20.39025132
139RAF10.35474818
140UHMK10.35304792
141MOS0.34131127
142AKT20.34072788
143KSR10.33599336
144CSNK1G10.30498001
145RPS6KB10.30063760

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.87696909
2Cell cycle_Homo sapiens_hsa041102.79161449
3Proteasome_Homo sapiens_hsa030502.69891902
4Mismatch repair_Homo sapiens_hsa034302.67530417
5Spliceosome_Homo sapiens_hsa030402.61660651
6RNA transport_Homo sapiens_hsa030132.39624450
7Base excision repair_Homo sapiens_hsa034102.22904696
8* mRNA surveillance pathway_Homo sapiens_hsa030152.15448328
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05664678
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96118137
11Homologous recombination_Homo sapiens_hsa034401.95783760
12Non-homologous end-joining_Homo sapiens_hsa034501.95407172
13RNA degradation_Homo sapiens_hsa030181.91132960
14Fanconi anemia pathway_Homo sapiens_hsa034601.77126957
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75484556
16Nucleotide excision repair_Homo sapiens_hsa034201.74699072
17One carbon pool by folate_Homo sapiens_hsa006701.67593071
18MicroRNAs in cancer_Homo sapiens_hsa052061.61409034
19Huntingtons disease_Homo sapiens_hsa050161.52827175
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50051943
21Basal transcription factors_Homo sapiens_hsa030221.48243020
22p53 signaling pathway_Homo sapiens_hsa041151.46495181
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42139627
24Chronic myeloid leukemia_Homo sapiens_hsa052201.40903700
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.40344930
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36443358
27Parkinsons disease_Homo sapiens_hsa050121.35529134
28Colorectal cancer_Homo sapiens_hsa052101.35184175
29Viral carcinogenesis_Homo sapiens_hsa052031.31735021
30Oocyte meiosis_Homo sapiens_hsa041141.30822341
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30679526
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30443062
33HTLV-I infection_Homo sapiens_hsa051661.29193004
34mTOR signaling pathway_Homo sapiens_hsa041501.28787446
35Oxidative phosphorylation_Homo sapiens_hsa001901.25611303
36Antigen processing and presentation_Homo sapiens_hsa046121.23205356
37Notch signaling pathway_Homo sapiens_hsa043301.21586104
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20973992
39Purine metabolism_Homo sapiens_hsa002301.19807926
40TGF-beta signaling pathway_Homo sapiens_hsa043501.15182512
41Systemic lupus erythematosus_Homo sapiens_hsa053221.15093950
42Adherens junction_Homo sapiens_hsa045201.14667800
43Basal cell carcinoma_Homo sapiens_hsa052171.12182490
44Pancreatic cancer_Homo sapiens_hsa052121.11746226
45Hippo signaling pathway_Homo sapiens_hsa043901.11515093
46Small cell lung cancer_Homo sapiens_hsa052221.10875087
47Thyroid cancer_Homo sapiens_hsa052161.10155652
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06906909
49Endometrial cancer_Homo sapiens_hsa052131.06874466
50Prostate cancer_Homo sapiens_hsa052151.02473713
51Non-small cell lung cancer_Homo sapiens_hsa052230.99569311
52Wnt signaling pathway_Homo sapiens_hsa043100.98152600
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97935834
54Steroid biosynthesis_Homo sapiens_hsa001000.97873547
55Herpes simplex infection_Homo sapiens_hsa051680.97732256
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.96854985
57Epstein-Barr virus infection_Homo sapiens_hsa051690.96612128
58Hedgehog signaling pathway_Homo sapiens_hsa043400.96536104
59Alcoholism_Homo sapiens_hsa050340.95129866
60Propanoate metabolism_Homo sapiens_hsa006400.94131719
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93656995
62Lysine degradation_Homo sapiens_hsa003100.88997942
63Proteoglycans in cancer_Homo sapiens_hsa052050.86642837
64RNA polymerase_Homo sapiens_hsa030200.86220660
65Bladder cancer_Homo sapiens_hsa052190.84123342
66Glioma_Homo sapiens_hsa052140.82665657
67Ribosome_Homo sapiens_hsa030100.80446919
68Primary immunodeficiency_Homo sapiens_hsa053400.79860952
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.79599846
70T cell receptor signaling pathway_Homo sapiens_hsa046600.78881961
71Hepatitis B_Homo sapiens_hsa051610.78686205
72Acute myeloid leukemia_Homo sapiens_hsa052210.77680532
73N-Glycan biosynthesis_Homo sapiens_hsa005100.76191110
74Renal cell carcinoma_Homo sapiens_hsa052110.75378859
75Pathways in cancer_Homo sapiens_hsa052000.73917667
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73575418
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73008503
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.72119146
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69906751
80Prolactin signaling pathway_Homo sapiens_hsa049170.69883301
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68924398
82Circadian rhythm_Homo sapiens_hsa047100.68536285
83FoxO signaling pathway_Homo sapiens_hsa040680.67195901
84Focal adhesion_Homo sapiens_hsa045100.64461013
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64051706
86Estrogen signaling pathway_Homo sapiens_hsa049150.62361949
87Pyrimidine metabolism_Homo sapiens_hsa002400.62129543
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61915996
89Folate biosynthesis_Homo sapiens_hsa007900.61745637
90Dorso-ventral axis formation_Homo sapiens_hsa043200.61507171
91B cell receptor signaling pathway_Homo sapiens_hsa046620.61488034
92Type II diabetes mellitus_Homo sapiens_hsa049300.59563618
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58179906
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57676408
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57402857
96Melanoma_Homo sapiens_hsa052180.57226515
97Viral myocarditis_Homo sapiens_hsa054160.55651951
98Regulation of autophagy_Homo sapiens_hsa041400.55405863
99Measles_Homo sapiens_hsa051620.54755506
100Apoptosis_Homo sapiens_hsa042100.54426324
101Inositol phosphate metabolism_Homo sapiens_hsa005620.54242535
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52952529
103Protein export_Homo sapiens_hsa030600.51787725
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50536458
105Alzheimers disease_Homo sapiens_hsa050100.50410756
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.49242751
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48274245
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46530718
109VEGF signaling pathway_Homo sapiens_hsa043700.46529601
110Platelet activation_Homo sapiens_hsa046110.45846808
111Olfactory transduction_Homo sapiens_hsa047400.45008708
112ErbB signaling pathway_Homo sapiens_hsa040120.44982791
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44800498
114Choline metabolism in cancer_Homo sapiens_hsa052310.44032973
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.43751034
116MAPK signaling pathway_Homo sapiens_hsa040100.43720747
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43671654
118Selenocompound metabolism_Homo sapiens_hsa004500.42489573
119Tight junction_Homo sapiens_hsa045300.41909432
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41154934
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40247806
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40038940
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39733764
124Insulin resistance_Homo sapiens_hsa049310.39560293
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36331109
126Phototransduction_Homo sapiens_hsa047440.36167559
127Pyruvate metabolism_Homo sapiens_hsa006200.35010445
128Shigellosis_Homo sapiens_hsa051310.33976161
129Cardiac muscle contraction_Homo sapiens_hsa042600.33346822
130Metabolic pathways_Homo sapiens_hsa011000.28096034
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26386935
132Butanoate metabolism_Homo sapiens_hsa006500.22473111
133Fatty acid biosynthesis_Homo sapiens_hsa000610.17167511
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15105598
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14240590
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12063885
137Sulfur relay system_Homo sapiens_hsa041220.11145083
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10730737
139Collecting duct acid secretion_Homo sapiens_hsa049660.10374010
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09313243
141Glutathione metabolism_Homo sapiens_hsa004800.08918580

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