FITM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: FIT1 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)7.41832353
2actin-myosin filament sliding (GO:0033275)7.41832353
3sarcomere organization (GO:0045214)7.27608978
4response to muscle activity (GO:0014850)6.64984698
5cardiac myofibril assembly (GO:0055003)6.41917166
6regulation of skeletal muscle contraction (GO:0014819)6.38042762
7myofibril assembly (GO:0030239)6.33206935
8actin-mediated cell contraction (GO:0070252)6.09534201
9skeletal muscle fiber development (GO:0048741)5.91796760
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.77651719
11tricarboxylic acid cycle (GO:0006099)5.58667689
12carnitine shuttle (GO:0006853)5.48890816
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.36542154
14myotube cell development (GO:0014904)5.34962368
15cardiac muscle contraction (GO:0060048)5.29322767
16plasma membrane repair (GO:0001778)5.22999991
17muscle system process (GO:0003012)5.14689094
18negative regulation of potassium ion transmembrane transport (GO:1901380)5.08897705
19fatty acid transmembrane transport (GO:1902001)5.06940910
20sarcoplasmic reticulum calcium ion transport (GO:0070296)4.96251753
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.94801132
22striated muscle contraction (GO:0006941)4.84839724
23cardiac muscle cell development (GO:0055013)4.82978624
242-oxoglutarate metabolic process (GO:0006103)4.82478776
25lysine catabolic process (GO:0006554)4.76501702
26lysine metabolic process (GO:0006553)4.76501702
27muscle fiber development (GO:0048747)4.71600376
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.68400705
29actomyosin structure organization (GO:0031032)4.66732682
30actin filament-based movement (GO:0030048)4.52488402
31cardiac cell development (GO:0055006)4.51464041
32skeletal muscle tissue development (GO:0007519)4.48309420
33skeletal muscle contraction (GO:0003009)4.46952999
34glycogen biosynthetic process (GO:0005978)4.46022142
35glucan biosynthetic process (GO:0009250)4.46022142
36regulation of relaxation of muscle (GO:1901077)4.39086992
37heart process (GO:0003015)4.37943626
38heart contraction (GO:0060047)4.37943626
39muscle cell fate commitment (GO:0042693)4.35883572
40cardiac muscle tissue morphogenesis (GO:0055008)4.33863518
41aspartate family amino acid catabolic process (GO:0009068)4.30932212
42response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.30803898
43regulation of actin filament-based movement (GO:1903115)4.29401295
44positive regulation of myotube differentiation (GO:0010831)4.27319574
45adult heart development (GO:0007512)4.26706851
46regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.25618289
47regulation of acyl-CoA biosynthetic process (GO:0050812)4.22624203
48cardiac muscle hypertrophy (GO:0003300)4.21853569
49carnitine transmembrane transport (GO:1902603)4.19943049
50muscle cell cellular homeostasis (GO:0046716)4.16874525
51fatty acid beta-oxidation (GO:0006635)4.13740421
52ventricular cardiac muscle cell action potential (GO:0086005)4.13232618
53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.09989820
54striated muscle hypertrophy (GO:0014897)4.06796936
55positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.06684739
56creatine metabolic process (GO:0006600)4.06185848
57striated muscle cell development (GO:0055002)4.03928172
58bundle of His cell to Purkinje myocyte communication (GO:0086069)4.03040036
59amino-acid betaine transport (GO:0015838)4.02740259
60carnitine transport (GO:0015879)4.02740259
61muscle tissue morphogenesis (GO:0060415)3.98765721
62regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.95532138
63ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.94119595
64skeletal muscle tissue regeneration (GO:0043403)3.93743503
65cardiac muscle adaptation (GO:0014887)3.93736479
66cardiac muscle hypertrophy in response to stress (GO:0014898)3.93736479
67muscle hypertrophy in response to stress (GO:0003299)3.93736479
68striated muscle atrophy (GO:0014891)3.92232537
69regulation of cell communication by electrical coupling (GO:0010649)3.89254837
70NADH metabolic process (GO:0006734)3.88526645
71polysaccharide catabolic process (GO:0000272)3.85763102
72regulation of coenzyme metabolic process (GO:0051196)3.85070397
73regulation of cofactor metabolic process (GO:0051193)3.85070397
74regulation of calcium ion transmembrane transporter activity (GO:1901019)3.84474948
75regulation of calcium ion transmembrane transport (GO:1903169)3.84474948
76heart trabecula formation (GO:0060347)3.83957131
77glyoxylate metabolic process (GO:0046487)3.81928063
78muscle organ development (GO:0007517)3.78597026
79muscle structure development (GO:0061061)3.77527262
80mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74665928
81acetyl-CoA metabolic process (GO:0006084)3.74665147
82regulation of sarcomere organization (GO:0060297)3.73971698
83muscle adaptation (GO:0043500)3.73582205
84regulation of striated muscle contraction (GO:0006942)3.72531818
85cellular ketone body metabolic process (GO:0046950)3.71520299
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69254748
87oxidative phosphorylation (GO:0006119)3.68819609
88glycogen catabolic process (GO:0005980)3.68058137
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.66047716
90muscle hypertrophy (GO:0014896)3.63476964
91oxaloacetate metabolic process (GO:0006107)3.62222810
92fatty acid catabolic process (GO:0009062)3.60705404
93fatty acid oxidation (GO:0019395)3.59262468
94respiratory electron transport chain (GO:0022904)3.58826283
95glycogen metabolic process (GO:0005977)3.57622344
96kynurenine metabolic process (GO:0070189)3.57547744
97regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.54349723
98negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.52945114
99negative regulation of calcium ion transmembrane transport (GO:1903170)3.52945114
100succinate metabolic process (GO:0006105)3.52941086
101skeletal muscle adaptation (GO:0043501)3.52081188
102short-chain fatty acid metabolic process (GO:0046459)3.51830028
103lipid oxidation (GO:0034440)3.51771002
104gluconeogenesis (GO:0006094)3.50957297
105regulation of ATPase activity (GO:0043462)3.50820653
106regulation of ATP catabolic process (GO:1903289)3.50820653
107glucan metabolic process (GO:0044042)3.50730830
108cellular glucan metabolic process (GO:0006073)3.50730830
109energy coupled proton transport, down electrochemical gradient (GO:0015985)3.48311764
110ATP synthesis coupled proton transport (GO:0015986)3.48311764
111muscle atrophy (GO:0014889)3.48269046
112electron transport chain (GO:0022900)3.47854002
113regulation of fatty acid oxidation (GO:0046320)3.47500925
114muscle cell development (GO:0055001)3.47367551
115regulation of myoblast differentiation (GO:0045661)3.47343903
116L-phenylalanine metabolic process (GO:0006558)3.47211386
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.47211386
118glucan catabolic process (GO:0009251)3.46897938
119branched-chain amino acid catabolic process (GO:0009083)3.46817557
120L-phenylalanine catabolic process (GO:0006559)3.41211853
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.41211853
122response to activity (GO:0014823)3.40906938
123regulation of muscle system process (GO:0090257)3.39923319
124positive regulation of myoblast differentiation (GO:0045663)3.39094704
125regulation of muscle contraction (GO:0006937)3.38404267
126tricarboxylic acid metabolic process (GO:0072350)3.37318546
127muscle contraction (GO:0006936)3.36603073
128response to inactivity (GO:0014854)3.32399449
129fructose metabolic process (GO:0006000)3.31362441
130regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.31319995
131pyrimidine ribonucleoside catabolic process (GO:0046133)3.31033998
132regulation of membrane repolarization (GO:0060306)3.29111343
133positive regulation of cation channel activity (GO:2001259)3.28617271
134striated muscle tissue development (GO:0014706)3.27685859
135monocarboxylic acid catabolic process (GO:0072329)3.27256330
136muscle organ morphogenesis (GO:0048644)3.26099326
137regulation of the force of heart contraction (GO:0002026)3.26021308
138regulation of sulfur metabolic process (GO:0042762)3.25353651
139amino-acid betaine metabolic process (GO:0006577)3.25187091
140cellular polysaccharide catabolic process (GO:0044247)3.24721279
141relaxation of muscle (GO:0090075)3.23682474
142carnitine metabolic process (GO:0009437)3.23339933
143quaternary ammonium group transport (GO:0015697)3.23010411
144branched-chain amino acid metabolic process (GO:0009081)3.22513536
145negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.21511433
146striated muscle adaptation (GO:0014888)3.19184069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.69746201
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.40500843
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.16515927
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.83229714
5EZH2_22144423_ChIP-Seq_EOC_Human4.57414369
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.23975002
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.07717641
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.87521082
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.63328156
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.58700737
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.42464909
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.07382634
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.92181238
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.90360341
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.90360341
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.80626940
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.48384086
18ZNF263_19887448_ChIP-Seq_K562_Human2.47403731
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45581566
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.22665330
21MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.97231898
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96508343
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96382968
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91615600
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90532791
26CLOCK_20551151_ChIP-Seq_293T_Human1.89054575
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68120213
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63866656
29GATA4_21415370_ChIP-Seq_HL-1_Mouse1.63463627
30NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48275474
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47819229
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41572398
33PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41509727
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.39561469
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.39397798
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33602095
37BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31091582
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31040306
39GATA1_22025678_ChIP-Seq_K562_Human1.28165258
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.27990846
41PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25103212
42NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23969584
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22355245
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19396404
45STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.19248195
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19006117
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17026787
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.15272999
49DROSHA_22980978_ChIP-Seq_HELA_Human1.14914148
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13530477
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12709518
52CTCF_27219007_Chip-Seq_Bcells_Human1.12678095
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.10976840
54CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08378891
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08342554
56LXR_22292898_ChIP-Seq_THP-1_Human1.07980968
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05060154
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04975411
59SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95693324
60OCT4_20526341_ChIP-Seq_ESCs_Human0.95095700
61AR_21572438_ChIP-Seq_LNCaP_Human0.92992329
62ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92082701
63RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91320013
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91299014
65HTT_18923047_ChIP-ChIP_STHdh_Human0.89485137
66HNF4A_19822575_ChIP-Seq_HepG2_Human0.88599108
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88380798
68ESR1_21235772_ChIP-Seq_MCF-7_Human0.87366846
69CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86791155
70TP63_22573176_ChIP-Seq_HFKS_Human0.86354549
71SPI1_20517297_ChIP-Seq_HL60_Human0.86163946
72PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86078015
73TCF7_22412390_ChIP-Seq_EML_Mouse0.85746712
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84878632
75P68_20966046_ChIP-Seq_HELA_Human0.84649359
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84129125
77CRX_20693478_ChIP-Seq_RETINA_Mouse0.83454922
78CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83453124
79* RACK7_27058665_Chip-Seq_MCF-7_Human0.83252954
80SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82812208
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.82728717
82CBX2_27304074_Chip-Seq_ESCs_Mouse0.82284530
83IGF1R_20145208_ChIP-Seq_DFB_Human0.82128953
84PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.80842313
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80800931
86GATA1_19941826_ChIP-Seq_K562_Human0.80730159
87GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80722741
88BCL6_27268052_Chip-Seq_Bcells_Human0.80718053
89BCOR_27268052_Chip-Seq_Bcells_Human0.79783623
90CTCF_21964334_Chip-Seq_Bcells_Human0.79480661
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78214907
92FOXH1_21741376_ChIP-Seq_ESCs_Human0.76997300
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76164265
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76079027
95ATF3_27146783_Chip-Seq_COLON_Human0.76057783
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75339143
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.74047448
98SMC1_22415368_ChIP-Seq_MEFs_Mouse0.73953230
99DPY_21335234_ChIP-Seq_ESCs_Mouse0.73614262
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.73312944
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72879865
102E2F1_20622854_ChIP-Seq_HELA_Human0.72366808
103MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.71956296
104OCT4_21477851_ChIP-Seq_ESCs_Mouse0.71523884
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71326642
106EZH2_27294783_Chip-Seq_NPCs_Mouse0.71318278
107CEBPB_22108803_ChIP-Seq_LS180_Human0.70325016
108TP53_23651856_ChIP-Seq_MEFs_Mouse0.69902660
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.69362564
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69309908
111SA1_27219007_Chip-Seq_Bcells_Human0.68920261
112GATA2_19941826_ChIP-Seq_K562_Human0.68781974
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68670198
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.68589923
115STAT1_20625510_ChIP-Seq_HELA_Human0.68492128
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68466438
117MYC_27129775_Chip-Seq_CORNEA_Mouse0.68381937
118CTCF_26484167_Chip-Seq_Bcells_Mouse0.68334320
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.67904594
120P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.67557820
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67114123
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.66594047
123CSB_26484114_Chip-Seq_FIBROBLAST_Human0.66252263
124JARID2_20075857_ChIP-Seq_MESCs_Mouse0.65793049
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65455709
126EGR1_19032775_ChIP-ChIP_M12_Human0.65195639
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65186999
128CBP_21632823_ChIP-Seq_H3396_Human0.64978075
129RAC3_21632823_ChIP-Seq_H3396_Human0.64841940
130TAF2_19829295_ChIP-Seq_ESCs_Human0.64607822
131SOX2_27498859_Chip-Seq_STOMACH_Mouse0.63792684
132CREB1_26743006_Chip-Seq_LNCaP_Human0.63498230
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.62995455
134* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62886323
135NANOG_20526341_ChIP-Seq_ESCs_Human0.62218612
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.62030835
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.61756585
138ELK3_25401928_ChIP-Seq_HUVEC_Human0.61298660
139STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.60698190
140KDM2B_26808549_Chip-Seq_DND41_Human0.60467148
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.60420448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.79187379
2MP0003646_muscle_fatigue5.54658323
3MP0000751_myopathy4.74339643
4MP0000749_muscle_degeneration4.36013605
5MP0004084_abnormal_cardiac_muscle4.32602876
6MP0004036_abnormal_muscle_relaxation4.02219857
7MP0004215_abnormal_myocardial_fiber3.45056087
8MP0004145_abnormal_muscle_electrophysio3.33762249
9MP0005330_cardiomyopathy3.31751641
10MP0004087_abnormal_muscle_fiber2.95194256
11MP0002139_abnormal_hepatobiliary_system2.93009883
12MP0002106_abnormal_muscle_physiology2.64663834
13MP0005620_abnormal_muscle_contractility2.62632822
14MP0005360_urolithiasis2.62469476
15MP0004130_abnormal_muscle_cell2.62002945
16MP0002269_muscular_atrophy2.61628265
17MP0003806_abnormal_nucleotide_metabolis2.58036743
18MP0002972_abnormal_cardiac_muscle2.53647887
19MP0005085_abnormal_gallbladder_physiolo2.51967411
20MP0000750_abnormal_muscle_regeneration2.50961800
21MP0000747_muscle_weakness2.45235773
22MP0006036_abnormal_mitochondrial_physio2.21124088
23MP0000759_abnormal_skeletal_muscle2.19057841
24MP0005365_abnormal_bile_salt2.17902689
25MP0003137_abnormal_impulse_conducting2.16569168
26MP0005369_muscle_phenotype2.14709910
27MP0008775_abnormal_heart_ventricle2.12499338
28MP0010630_abnormal_cardiac_muscle2.11189847
29MP0005385_cardiovascular_system_phenoty2.07913394
30MP0001544_abnormal_cardiovascular_syste2.07913394
31MP0006138_congestive_heart_failure1.85338652
32MP0004484_altered_response_of1.83335804
33MP0003221_abnormal_cardiomyocyte_apopto1.81301749
34MP0008875_abnormal_xenobiotic_pharmacok1.74703569
35MP0004233_abnormal_muscle_weight1.69277911
36MP0002332_abnormal_exercise_endurance1.61533841
37MP0005666_abnormal_adipose_tissue1.50857242
38MP0003252_abnormal_bile_duct1.50341266
39MP0004085_abnormal_heartbeat1.49262360
40MP0005083_abnormal_biliary_tract1.44198853
41MP0003828_pulmonary_edema1.41842663
42MP0009840_abnormal_foam_cell1.39351628
43MP0005332_abnormal_amino_acid1.35466606
44MP0005670_abnormal_white_adipose1.35178114
45MP0003195_calcinosis1.34242990
46MP0005451_abnormal_body_composition1.33887298
47MP0002127_abnormal_cardiovascular_syste1.28530244
48MP0006035_abnormal_mitochondrial_morpho1.25944135
49MP0010329_abnormal_lipoprotein_level1.24715984
50MP0003950_abnormal_plasma_membrane1.24222829
51MP0004270_analgesia1.24152021
52MP0005319_abnormal_enzyme/_coenzyme1.19711294
53MP0004510_myositis1.18531771
54MP0005266_abnormal_metabolism1.14313166
55MP0004185_abnormal_adipocyte_glucose1.07811309
56MP0002118_abnormal_lipid_homeostasis1.02674459
57MP0003705_abnormal_hypodermis_morpholog1.00868467
58MP0001661_extended_life_span0.96126962
59MP0002108_abnormal_muscle_morphology0.96010898
60MP0002971_abnormal_brown_adipose0.95042881
61MP0000343_altered_response_to0.92475422
62MP0005375_adipose_tissue_phenotype0.91742741
63MP0010368_abnormal_lymphatic_system0.91710895
64MP0003567_abnormal_fetal_cardiomyocyte0.91384516
65MP0005584_abnormal_enzyme/coenzyme_acti0.88600609
66MP0004043_abnormal_pH_regulation0.88174426
67MP0000266_abnormal_heart_morphology0.87378578
68MP0002234_abnormal_pharynx_morphology0.85161768
69MP0000230_abnormal_systemic_arterial0.82947517
70MP0000609_abnormal_liver_physiology0.80590739
71MP0001666_abnormal_nutrient_absorption0.78317871
72MP0005165_increased_susceptibility_to0.77614200
73MP0002078_abnormal_glucose_homeostasis0.74329869
74MP0000733_abnormal_muscle_development0.71854247
75MP0003191_abnormal_cellular_cholesterol0.71649239
76MP0003656_abnormal_erythrocyte_physiolo0.68318926
77MP0003045_fibrosis0.67402552
78MP0009780_abnormal_chondrocyte_physiolo0.66857165
79MP0002128_abnormal_blood_circulation0.62088933
80MP0003279_aneurysm0.61256659
81MP0004147_increased_porphyrin_level0.60040330
82MP0009643_abnormal_urine_homeostasis0.59903932
83MP0005334_abnormal_fat_pad0.56786241
84MP0001299_abnormal_eye_distance/0.55061594
85MP0005535_abnormal_body_temperature0.54299708
86MP0000372_irregular_coat_pigmentation0.52362665
87MP0005376_homeostasis/metabolism_phenot0.52057968
88MP0002138_abnormal_hepatobiliary_system0.48441719
89MP0003186_abnormal_redox_activity0.48211723
90MP0001764_abnormal_homeostasis0.46224888
91MP0003879_abnormal_hair_cell0.44704779
92MP0008961_abnormal_basal_metabolism0.43025532
93MP0009697_abnormal_copulation0.40960248
94MP0005187_abnormal_penis_morphology0.38818759
95MP0002909_abnormal_adrenal_gland0.38612364
96MP0000598_abnormal_liver_morphology0.38411829
97MP0005167_abnormal_blood-brain_barrier0.38346005
98MP0004134_abnormal_chest_morphology0.38342169
99MP0008569_lethality_at_weaning0.37190385
100MP0009642_abnormal_blood_homeostasis0.37024118
101MP0004019_abnormal_vitamin_homeostasis0.35946459
102MP0002822_catalepsy0.35436068
103MP0002638_abnormal_pupillary_reflex0.34937328
104MP0003566_abnormal_cell_adhesion0.34844744
105MP0000767_abnormal_smooth_muscle0.34734987
106MP0000013_abnormal_adipose_tissue0.34498167
107MP0010030_abnormal_orbit_morphology0.34403748
108MP0000003_abnormal_adipose_tissue0.34156556
109MP0005636_abnormal_mineral_homeostasis0.33466247
110MP0000762_abnormal_tongue_morphology0.33321667
111MP0009115_abnormal_fat_cell0.32621633
112MP0001879_abnormal_lymphatic_vessel0.31821318
113MP0005166_decreased_susceptibility_to0.31386197
114MP0003948_abnormal_gas_homeostasis0.30868645
115MP0001346_abnormal_lacrimal_gland0.29239690
116MP0005452_abnormal_adipose_tissue0.28166194
117MP0001853_heart_inflammation0.27664230
118MP0002114_abnormal_axial_skeleton0.26349245
119MP0004142_abnormal_muscle_tone0.25790904
120MP0002896_abnormal_bone_mineralization0.25300863
121MP0009672_abnormal_birth_weight0.23500312
122MP0002249_abnormal_larynx_morphology0.19974264
123MP0009250_abnormal_appendicular_skeleto0.19697027
124MP0001943_abnormal_respiration0.18825546
125MP0004858_abnormal_nervous_system0.17643988
126MP0002734_abnormal_mechanical_nocicepti0.16596290
127MP0002066_abnormal_motor_capabilities/c0.15133508

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.82421461
2Exercise-induced muscle cramps (HP:0003710)6.62912539
3Calf muscle hypertrophy (HP:0008981)6.28458020
4Muscle hypertrophy of the lower extremities (HP:0008968)6.16185693
5Sudden death (HP:0001699)5.94688893
6Myoglobinuria (HP:0002913)5.31507266
7Ventricular tachycardia (HP:0004756)5.13108964
8Muscle fiber splitting (HP:0003555)5.07499180
9Hyporeflexia of lower limbs (HP:0002600)4.77695764
10Abnormality of the calf musculature (HP:0001430)4.66492155
11Muscle fiber inclusion bodies (HP:0100299)4.65573007
12Centrally nucleated skeletal muscle fibers (HP:0003687)4.61808317
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.46192229
14Subaortic stenosis (HP:0001682)4.44837031
15Abnormality of the left ventricular outflow tract (HP:0011103)4.44837031
16Rhabdomyolysis (HP:0003201)4.30693001
17EMG: myopathic abnormalities (HP:0003458)4.18107373
18Atrial fibrillation (HP:0005110)4.04072969
19Lipoatrophy (HP:0100578)4.02400894
20Calcaneovalgus deformity (HP:0001848)3.96304219
21Nemaline bodies (HP:0003798)3.89179147
22Type 1 muscle fiber predominance (HP:0003803)3.88334639
23Increased connective tissue (HP:0009025)3.83754195
24Difficulty running (HP:0009046)3.81540692
25Asymmetric septal hypertrophy (HP:0001670)3.75934001
26Primary atrial arrhythmia (HP:0001692)3.74231559
27Supraventricular tachycardia (HP:0004755)3.61539508
28Right ventricular cardiomyopathy (HP:0011663)3.60235237
29Absent phalangeal crease (HP:0006109)3.56082313
30Supraventricular arrhythmia (HP:0005115)3.53413083
31Deformed tarsal bones (HP:0008119)3.50246130
32Palpitations (HP:0001962)3.49156689
33Dilated cardiomyopathy (HP:0001644)3.48993017
34Myotonia (HP:0002486)3.37297324
35Muscle stiffness (HP:0003552)3.31397179
36Malignant hyperthermia (HP:0002047)3.29290146
37Ketoacidosis (HP:0001993)3.25341976
38Bundle branch block (HP:0011710)3.23311723
39Frequent falls (HP:0002359)3.20336069
40Ketosis (HP:0001946)3.18966880
41Hypoglycemic coma (HP:0001325)3.15304494
42Syncope (HP:0001279)3.12506502
43Abnormality of fatty-acid metabolism (HP:0004359)3.00698842
44Ventricular arrhythmia (HP:0004308)2.96064665
45Abnormal finger flexion creases (HP:0006143)2.93480825
46Hepatic necrosis (HP:0002605)2.93195915
47Prolonged QT interval (HP:0001657)2.91558231
48Heart block (HP:0012722)2.87388020
49Mildly elevated creatine phosphokinase (HP:0008180)2.85589280
50Cerebral edema (HP:0002181)2.78300593
51Distal arthrogryposis (HP:0005684)2.76946804
52Hyperammonemia (HP:0001987)2.76580696
53Dicarboxylic aciduria (HP:0003215)2.75643497
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75643497
55Difficulty climbing stairs (HP:0003551)2.74456027
56Atrioventricular block (HP:0001678)2.74003052
57Fetal akinesia sequence (HP:0001989)2.72485150
58Abnormal atrioventricular conduction (HP:0005150)2.69382135
59Bulbar palsy (HP:0001283)2.68512651
60Distal lower limb muscle weakness (HP:0009053)2.66052130
61Weak cry (HP:0001612)2.65604983
62Distal lower limb amyotrophy (HP:0008944)2.65420063
63Myopathic facies (HP:0002058)2.65337452
64Abnormal mitochondria in muscle tissue (HP:0008316)2.64482663
65Areflexia of lower limbs (HP:0002522)2.63429204
66Acute encephalopathy (HP:0006846)2.62716931
67Acute necrotizing encephalopathy (HP:0006965)2.60097371
68Gowers sign (HP:0003391)2.59092159
69Hyperglycinuria (HP:0003108)2.57557003
70Neck muscle weakness (HP:0000467)2.53495006
71Abnormality of the neuromuscular junction (HP:0003398)2.49071596
72Fatigable weakness (HP:0003473)2.49071596
73Abnormality of skeletal muscle fiber size (HP:0012084)2.47417888
74Round ear (HP:0100830)2.47355926
75Increased variability in muscle fiber diameter (HP:0003557)2.46131046
76Hepatocellular necrosis (HP:0001404)2.45402023
77Increased muscle lipid content (HP:0009058)2.42916207
78Scapular winging (HP:0003691)2.41767039
79Rimmed vacuoles (HP:0003805)2.38870322
80Ventricular fibrillation (HP:0001663)2.37646093
81Abnormality of serine family amino acid metabolism (HP:0010894)2.37345191
82Abnormality of glycine metabolism (HP:0010895)2.37345191
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.36232874
84Cholelithiasis (HP:0001081)2.32499643
85Ragged-red muscle fibers (HP:0003200)2.31801136
86Progressive muscle weakness (HP:0003323)2.31505702
87Abnormality of the calcaneus (HP:0008364)2.29200581
88Hypoalphalipoproteinemia (HP:0003233)2.28770477
89Hip contracture (HP:0003273)2.26171140
90Abnormality of the foot musculature (HP:0001436)2.24609199
91Xanthomatosis (HP:0000991)2.21898987
92Slender build (HP:0001533)2.21534164
93Popliteal pterygium (HP:0009756)2.20508739
94Mitochondrial inheritance (HP:0001427)2.19043460
95Intrahepatic cholestasis (HP:0001406)2.18414786
96Metabolic acidosis (HP:0001942)2.17019978
97Left ventricular hypertrophy (HP:0001712)2.16488047
98EMG: neuropathic changes (HP:0003445)2.16006609
99Increased CSF lactate (HP:0002490)2.13874256
100Abnormal gallbladder morphology (HP:0012437)2.13570331
101Hyperglycinemia (HP:0002154)2.13474942
102Progressive macrocephaly (HP:0004481)2.13263093
103Limb-girdle muscle atrophy (HP:0003797)2.12363642
104Lactic acidosis (HP:0003128)2.11543079
105Generalized aminoaciduria (HP:0002909)2.11432814
106Deep venous thrombosis (HP:0002625)2.10816800
107Exercise intolerance (HP:0003546)2.09164366
108Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08393489
109Gout (HP:0001997)2.07966394
110Abnormal EKG (HP:0003115)2.07250924
111Increased intramyocellular lipid droplets (HP:0012240)2.06770140
112Spinal rigidity (HP:0003306)2.06017813
113Conjunctival hamartoma (HP:0100780)2.05788714
114Proximal amyotrophy (HP:0007126)2.05499977
115Ulnar deviation of the wrist (HP:0003049)2.04953399
116Hyperkalemia (HP:0002153)2.04639130
117Generalized muscle weakness (HP:0003324)2.04601355
118Foot dorsiflexor weakness (HP:0009027)2.02140153
119Palmoplantar keratoderma (HP:0000982)2.02115821
120Waddling gait (HP:0002515)2.02032796
121Hyperinsulinemic hypoglycemia (HP:0000825)1.99083583
122Lethargy (HP:0001254)1.98840023
123Hyperlipoproteinemia (HP:0010980)1.98243004
124Hypolipoproteinemia (HP:0010981)1.97754063
125Lower limb amyotrophy (HP:0007210)1.97617980
126Abnormality of the shoulder girdle musculature (HP:0001435)1.94552307
127Testicular atrophy (HP:0000029)1.92146125
128Type 2 muscle fiber atrophy (HP:0003554)1.89762487
129Respiratory insufficiency due to muscle weakness (HP:0002747)1.89410499
130Muscular dystrophy (HP:0003560)1.86332112
131Abnormality of glycolysis (HP:0004366)1.85265910
132Muscle fiber atrophy (HP:0100295)1.76360413
133Limb-girdle muscle weakness (HP:0003325)1.67218449
134Metatarsus adductus (HP:0001840)1.63958557
135Long clavicles (HP:0000890)1.61773353
136Facial diplegia (HP:0001349)1.61070965
137Abnormality of placental membranes (HP:0011409)1.59549537
138Amniotic constriction ring (HP:0009775)1.59549537
139Nonprogressive disorder (HP:0003680)1.58581654
140Abnormality of the musculature of the pelvis (HP:0001469)1.57449947
141Abnormality of the hip-girdle musculature (HP:0001445)1.57449947
142Limited hip movement (HP:0008800)1.51527339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.35962979
2TTN6.04875281
3PHKG14.25101840
4PHKG24.25101840
5BCKDK3.98905552
6PDK32.95878443
7PDK42.95878443
8MYLK2.93556964
9PKN22.64172727
10TRIB32.55333453
11PINK12.32621208
12NEK12.31304572
13PIK3CA2.29705304
14LMTK22.22078077
15DMPK2.21364035
16MUSK2.00528994
17MAP2K31.79376523
18PDK21.76557152
19STK241.69110139
20PIK3CG1.58620010
21TIE11.56843987
22MAP3K71.50648623
23NME11.36177291
24MAPK121.33559026
25MOS1.29787401
26STK38L1.17664190
27SIK11.09827965
28EEF2K1.07851196
29LIMK11.05419220
30MAP2K41.00995524
31MAP3K30.99202040
32PAK30.98275956
33PRKAA20.98027864
34INSRR0.98000752
35MARK10.97585520
36FLT30.96247961
37PRKAA10.95087990
38ZAK0.92434618
39PRKD10.91443319
40WNK40.90489942
41ILK0.84760217
42CCNB10.84722081
43MAP3K50.83479095
44CAMK2D0.82403574
45DYRK1B0.81075193
46FGFR40.80923307
47MAPKAPK30.76463708
48RIPK10.75636939
49GRK70.72771444
50NEK90.71772226
51PKN10.70695782
52ROCK10.69558916
53ERN10.66528596
54MAP2K60.66487720
55TRPM70.62372808
56MAPK110.61617424
57MAP2K10.60941449
58STK40.60440914
59CDC42BPA0.58934605
60EPHB10.58261837
61KDR0.57852717
62ERBB30.55658395
63CAMK2G0.53858266
64KSR20.53281280
65MAP3K110.51646629
66MAP3K130.50878215
67DAPK30.50802822
68CAMK40.50108486
69PTK60.50011090
70TGFBR20.46957997
71PRKACB0.46483169
72STK380.46006542
73AKT20.45314410
74PDGFRA0.40836304
75CAMK2B0.39991672
76PRKACG0.39069861
77ICK0.38586403
78PDPK10.38131217
79PRPF4B0.36031734
80RPS6KC10.35379911
81RPS6KL10.35379911
82PRKACA0.35294858
83CAMK2A0.34279543
84LATS10.33379175
85MAP3K100.33359068
86PTK2B0.32573460
87MARK20.31784571
88TBK10.30994517
89RPS6KA60.29231811
90SGK20.29000824
91MAP3K60.28362678
92PDK10.27706383
93TAOK20.27265225
94ROCK20.25366717
95NME20.25353766
96SGK30.25272803
97MAPK100.24882107
98WNK10.24284525
99MAPK40.23127686
100CAMK10.22308081
101TAOK10.21822884
102ABL20.21732636
103JAK20.21688863
104RPS6KA10.20580263
105PRKG10.20486683
106STK390.19845143
107MAPK70.19720039
108ARAF0.19571198
109RPS6KB10.19219421
110RPS6KB20.19216059
111JAK10.18972510
112ZAP700.18653875
113EPHA30.18489908
114MTOR0.18314807
115PRKCH0.17625990
116MAP3K10.16896864
117RPS6KA30.16776116
118SGK10.16310695
119TYK20.16135811
120MARK30.15348928
121SGK2230.12280687
122SGK4940.12280687
123EPHB20.11915778
124RAF10.10699626
125LATS20.10610264
126MAPK130.09578207
127PRKCE0.09533033
128STK110.09416888
129NLK0.08160717
130KSR10.07890551

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.26355959
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.91373925
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.81048719
4Propanoate metabolism_Homo sapiens_hsa006403.35067978
5Fatty acid degradation_Homo sapiens_hsa000713.22546111
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.89898548
7Cardiac muscle contraction_Homo sapiens_hsa042602.83255494
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59170788
9Carbon metabolism_Homo sapiens_hsa012002.44723760
10Fatty acid metabolism_Homo sapiens_hsa012122.37743996
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.24307089
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.23957811
13Parkinsons disease_Homo sapiens_hsa050122.15914796
14Pyruvate metabolism_Homo sapiens_hsa006202.14724945
15Dilated cardiomyopathy_Homo sapiens_hsa054142.13899852
16Arginine biosynthesis_Homo sapiens_hsa002202.13711959
17Butanoate metabolism_Homo sapiens_hsa006502.13265780
18Oxidative phosphorylation_Homo sapiens_hsa001902.11909108
19Tryptophan metabolism_Homo sapiens_hsa003802.04100464
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74798588
21Starch and sucrose metabolism_Homo sapiens_hsa005001.73267880
22PPAR signaling pathway_Homo sapiens_hsa033201.70047812
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66596589
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63533602
25Peroxisome_Homo sapiens_hsa041461.63213940
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62798176
27Biosynthesis of amino acids_Homo sapiens_hsa012301.62057929
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57238339
29Alzheimers disease_Homo sapiens_hsa050101.55718512
30Fatty acid elongation_Homo sapiens_hsa000621.54658701
31beta-Alanine metabolism_Homo sapiens_hsa004101.50956712
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42432095
33Nitrogen metabolism_Homo sapiens_hsa009101.42378685
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.40368525
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39461942
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22416832
37Phenylalanine metabolism_Homo sapiens_hsa003601.22361165
38Huntingtons disease_Homo sapiens_hsa050161.20112397
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14361797
40Arginine and proline metabolism_Homo sapiens_hsa003301.12776569
41Complement and coagulation cascades_Homo sapiens_hsa046100.97637859
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94661306
43Tyrosine metabolism_Homo sapiens_hsa003500.92168232
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.91746990
45Glucagon signaling pathway_Homo sapiens_hsa049220.91480813
46Renin secretion_Homo sapiens_hsa049240.90772330
47Insulin resistance_Homo sapiens_hsa049310.90588980
48Lysine degradation_Homo sapiens_hsa003100.90551205
49Bile secretion_Homo sapiens_hsa049760.86848368
50Gastric acid secretion_Homo sapiens_hsa049710.83684462
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82743327
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.81921964
53Chemical carcinogenesis_Homo sapiens_hsa052040.80250051
54Galactose metabolism_Homo sapiens_hsa000520.80118374
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78871195
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78459877
57Caffeine metabolism_Homo sapiens_hsa002320.76637374
58Fructose and mannose metabolism_Homo sapiens_hsa000510.75494066
59GnRH signaling pathway_Homo sapiens_hsa049120.74638814
60Sulfur metabolism_Homo sapiens_hsa009200.74299584
61Viral myocarditis_Homo sapiens_hsa054160.73477193
62Fat digestion and absorption_Homo sapiens_hsa049750.72208971
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70327920
64Histidine metabolism_Homo sapiens_hsa003400.68098086
65Insulin signaling pathway_Homo sapiens_hsa049100.67189254
66Selenocompound metabolism_Homo sapiens_hsa004500.65704885
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64863728
68Long-term potentiation_Homo sapiens_hsa047200.60834702
69Retinol metabolism_Homo sapiens_hsa008300.59617623
70Fatty acid biosynthesis_Homo sapiens_hsa000610.59305374
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57816387
72Pentose phosphate pathway_Homo sapiens_hsa000300.55722250
73AMPK signaling pathway_Homo sapiens_hsa041520.55634868
74ABC transporters_Homo sapiens_hsa020100.54533681
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53034460
76Insulin secretion_Homo sapiens_hsa049110.52212968
77Metabolic pathways_Homo sapiens_hsa011000.50119581
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49954648
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.48820809
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.48248738
81Sulfur relay system_Homo sapiens_hsa041220.47855110
82FoxO signaling pathway_Homo sapiens_hsa040680.46987502
83Glycerolipid metabolism_Homo sapiens_hsa005610.45013025
84Circadian entrainment_Homo sapiens_hsa047130.42497242
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41838870
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41827988
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41335247
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39228115
89cAMP signaling pathway_Homo sapiens_hsa040240.37366536
90MAPK signaling pathway_Homo sapiens_hsa040100.35339963
91Staphylococcus aureus infection_Homo sapiens_hsa051500.35109419
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34436133
93Salivary secretion_Homo sapiens_hsa049700.34054891
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.32311761
95Glutathione metabolism_Homo sapiens_hsa004800.31703137
96Folate biosynthesis_Homo sapiens_hsa007900.29776340
97Ovarian steroidogenesis_Homo sapiens_hsa049130.28575201
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28557802
99Cholinergic synapse_Homo sapiens_hsa047250.27005470
100VEGF signaling pathway_Homo sapiens_hsa043700.25730556
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24128557
102Calcium signaling pathway_Homo sapiens_hsa040200.23656673
103Pancreatic secretion_Homo sapiens_hsa049720.23517132
104Regulation of autophagy_Homo sapiens_hsa041400.23213212
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.21942360
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21809970
107Platelet activation_Homo sapiens_hsa046110.21716336
108Circadian rhythm_Homo sapiens_hsa047100.21478931
109HIF-1 signaling pathway_Homo sapiens_hsa040660.20782609
110mTOR signaling pathway_Homo sapiens_hsa041500.19102909
111Amphetamine addiction_Homo sapiens_hsa050310.18183364
112Adherens junction_Homo sapiens_hsa045200.16804915
113Melanogenesis_Homo sapiens_hsa049160.16636881
114Oxytocin signaling pathway_Homo sapiens_hsa049210.16514844
115Type II diabetes mellitus_Homo sapiens_hsa049300.15825673
116Tight junction_Homo sapiens_hsa045300.14890135
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.14625834
118Long-term depression_Homo sapiens_hsa047300.13912853
119Focal adhesion_Homo sapiens_hsa045100.13823150
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12282618
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12216694
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.10597977
123Glioma_Homo sapiens_hsa052140.10203110
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09654797
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.07166987
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06835739
127Gap junction_Homo sapiens_hsa045400.05695118
128Linoleic acid metabolism_Homo sapiens_hsa005910.03339504
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.00277389
130Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0264355
131Amoebiasis_Homo sapiens_hsa05146-0.0203115
132Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0082461
133Vitamin B6 metabolism_Homo sapiens_hsa00750-0.0072623

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