FITM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: FIT2 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1carnitine shuttle (GO:0006853)5.31529122
2fatty acid transmembrane transport (GO:1902001)5.30433829
3* regulation of sequestering of triglyceride (GO:0010889)5.12811296
4fatty acid beta-oxidation (GO:0006635)5.08550404
5regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.70661726
6tricarboxylic acid cycle (GO:0006099)4.69104220
7fatty acid catabolic process (GO:0009062)4.54865993
8fatty acid oxidation (GO:0019395)4.54735191
9lipid oxidation (GO:0034440)4.46660491
10biotin metabolic process (GO:0006768)4.44027358
11branched-chain amino acid catabolic process (GO:0009083)4.41894864
12valine metabolic process (GO:0006573)4.40678832
13alpha-linolenic acid metabolic process (GO:0036109)4.40249508
14lysine metabolic process (GO:0006553)4.38486960
15lysine catabolic process (GO:0006554)4.38486960
16positive regulation of fatty acid beta-oxidation (GO:0032000)4.35548312
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.34950740
182-oxoglutarate metabolic process (GO:0006103)4.30749352
19acetyl-CoA metabolic process (GO:0006084)4.26825729
20positive regulation of fatty acid oxidation (GO:0046321)4.25834759
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.25351574
22L-phenylalanine catabolic process (GO:0006559)4.25351574
23regulation of cell communication by electrical coupling (GO:0010649)4.23265214
24detection of calcium ion (GO:0005513)4.22403335
25cardiac muscle contraction (GO:0060048)4.12307280
26carnitine transmembrane transport (GO:1902603)4.11022326
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.10155392
28L-phenylalanine metabolic process (GO:0006558)4.10155392
29branched-chain amino acid metabolic process (GO:0009081)4.08550200
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.06697186
31regulation of actin filament-based movement (GO:1903115)4.04224987
32regulation of triglyceride catabolic process (GO:0010896)4.03951283
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.03454876
34ventricular cardiac muscle cell action potential (GO:0086005)4.00721795
35monocarboxylic acid catabolic process (GO:0072329)4.00151089
36regulation of fatty acid oxidation (GO:0046320)3.99049449
37regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.98145852
38short-chain fatty acid metabolic process (GO:0046459)3.92577567
39low-density lipoprotein particle clearance (GO:0034383)3.88236912
40NADH metabolic process (GO:0006734)3.86816246
41carnitine transport (GO:0015879)3.86699409
42amino-acid betaine transport (GO:0015838)3.86699409
43cell communication involved in cardiac conduction (GO:0086065)3.85551633
44cellular ketone body metabolic process (GO:0046950)3.83200807
45positive regulation of action potential (GO:0045760)3.82543117
46thioester biosynthetic process (GO:0035384)3.78935652
47acyl-CoA biosynthetic process (GO:0071616)3.78935652
48triglyceride catabolic process (GO:0019433)3.76733957
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.71030300
50aspartate family amino acid catabolic process (GO:0009068)3.70401774
51regulation of relaxation of muscle (GO:1901077)3.68000320
52regulation of acyl-CoA biosynthetic process (GO:0050812)3.62770929
53neutral lipid catabolic process (GO:0046461)3.62082454
54acylglycerol catabolic process (GO:0046464)3.62082454
55carnitine metabolic process (GO:0009437)3.61874335
56regulation of membrane repolarization (GO:0060306)3.61081057
57fatty acid homeostasis (GO:0055089)3.60943787
58amino-acid betaine metabolic process (GO:0006577)3.60376907
59tricarboxylic acid metabolic process (GO:0072350)3.56988337
60succinate metabolic process (GO:0006105)3.48436698
61response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.47897060
62sarcomere organization (GO:0045214)3.46906871
63regulation of the force of heart contraction (GO:0002026)3.44783274
64positive regulation of lipid catabolic process (GO:0050996)3.43419305
65aromatic amino acid family catabolic process (GO:0009074)3.42032492
66glyoxylate metabolic process (GO:0046487)3.41856879
67oxaloacetate metabolic process (GO:0006107)3.41775445
68relaxation of cardiac muscle (GO:0055119)3.40900152
69regulation of fatty acid beta-oxidation (GO:0031998)3.39919074
70adult heart development (GO:0007512)3.38601746
71plasma lipoprotein particle clearance (GO:0034381)3.36645180
72regulation of heart rate (GO:0002027)3.35205883
73regulation of cofactor metabolic process (GO:0051193)3.33745326
74regulation of coenzyme metabolic process (GO:0051196)3.33745326
75response to pheromone (GO:0019236)3.33586984
76cardiac muscle cell action potential (GO:0086001)3.32513588
77fatty-acyl-CoA biosynthetic process (GO:0046949)3.30521910
78regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.30417434
79ketone body metabolic process (GO:1902224)3.28707984
80regulation of striated muscle contraction (GO:0006942)3.28559335
81behavioral response to nicotine (GO:0035095)3.28228733
82cardiac muscle hypertrophy (GO:0003300)3.28056664
83positive regulation of heart rate (GO:0010460)3.27006925
84ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.25008654
85sulfur amino acid catabolic process (GO:0000098)3.23164351
86thioester metabolic process (GO:0035383)3.23009483
87acyl-CoA metabolic process (GO:0006637)3.23009483
88cardiac muscle cell action potential involved in contraction (GO:0086002)3.22332862
89cardiac muscle tissue morphogenesis (GO:0055008)3.21404097
90response to caffeine (GO:0031000)3.20066338
91adrenergic receptor signaling pathway (GO:0071875)3.19430725
92cell communication by electrical coupling (GO:0010644)3.18433097
93brown fat cell differentiation (GO:0050873)3.17362838
94organic acid catabolic process (GO:0016054)3.16977847
95carboxylic acid catabolic process (GO:0046395)3.16977847
96cardiac conduction (GO:0061337)3.16938224
97actomyosin structure organization (GO:0031032)3.16862175
98* triglyceride homeostasis (GO:0070328)3.14941217
99* acylglycerol homeostasis (GO:0055090)3.14941217
100regulation of action potential (GO:0098900)3.13293097
101complement activation, alternative pathway (GO:0006957)3.12886057
102fatty-acyl-CoA metabolic process (GO:0035337)3.12463902
103positive regulation of fatty acid metabolic process (GO:0045923)3.11899877
104regulation of cardiac muscle contraction (GO:0055117)3.11213371
105striated muscle hypertrophy (GO:0014897)3.10170968
106quaternary ammonium group transport (GO:0015697)3.08770629
107kynurenine metabolic process (GO:0070189)3.08748987
108regulation of cardiac muscle cell contraction (GO:0086004)3.08077002
109striated muscle contraction (GO:0006941)3.07857392
110positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.06637814
111cardiac myofibril assembly (GO:0055003)3.05040394
112actin-mediated cell contraction (GO:0070252)3.04827544
113phospholipid homeostasis (GO:0055091)3.04716426
114coenzyme catabolic process (GO:0009109)3.02177112
115negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.01942267
116regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01492185
117positive regulation of sodium ion transport (GO:0010765)3.00934574
118intracellular lipid transport (GO:0032365)2.98804803
119bile acid biosynthetic process (GO:0006699)2.98295470
120positive regulation of glycolytic process (GO:0045821)2.96898012
121creatine metabolic process (GO:0006600)2.96191170
122regulation of heart rate by cardiac conduction (GO:0086091)2.95828495
123regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94863187
124coenzyme A metabolic process (GO:0015936)2.94473793
125negative regulation of lipase activity (GO:0060192)2.92714741
126alpha-amino acid catabolic process (GO:1901606)2.92246314
127positive regulation of triglyceride metabolic process (GO:0090208)2.92126816
128myofibril assembly (GO:0030239)2.91317931
129ethanol oxidation (GO:0006069)2.91287127
130bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90838683
131regulation of cholesterol metabolic process (GO:0090181)2.90502098
132cardiac muscle cell development (GO:0055013)2.90433067
133muscle filament sliding (GO:0030049)2.90094960
134actin-myosin filament sliding (GO:0033275)2.90094960
135triglyceride metabolic process (GO:0006641)2.88561870
136cellular amino acid catabolic process (GO:0009063)2.85940062
137triglyceride biosynthetic process (GO:0019432)2.84882653
138regulation of skeletal muscle contraction (GO:0014819)2.83844590
139positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.83546834
140muscle tissue morphogenesis (GO:0060415)2.83255039
141neutral lipid biosynthetic process (GO:0046460)2.81933363
142acylglycerol biosynthetic process (GO:0046463)2.81933363
143negative regulation of potassium ion transmembrane transport (GO:1901380)2.81730978
144negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80007242
145macroautophagy (GO:0016236)2.76360152
146regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73939809
147action potential (GO:0001508)2.73811105
148response to inactivity (GO:0014854)2.73266254
149sarcoplasmic reticulum calcium ion transport (GO:0070296)2.73120738
150regulation of sarcomere organization (GO:0060297)2.69369988
151regulation of heart contraction (GO:0008016)2.68396720
152muscle hypertrophy (GO:0014896)2.63419904
153cardiac cell development (GO:0055006)2.63310400
154regulation of ATPase activity (GO:0043462)2.62187605
155regulation of ATP catabolic process (GO:1903289)2.62187605
156neuronal action potential (GO:0019228)2.59767860
157response to epinephrine (GO:0071871)2.56503978
158pyrimidine nucleobase catabolic process (GO:0006208)2.55863422
159positive regulation of heart contraction (GO:0045823)2.54891557
160neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.52303174
161regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50969627
162ubiquinone biosynthetic process (GO:0006744)2.50119891
163regulation of sodium ion transmembrane transport (GO:1902305)2.49285593
164membrane depolarization during action potential (GO:0086010)2.48692866
165toxin metabolic process (GO:0009404)2.47346827
166regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45015712
167ubiquinone metabolic process (GO:0006743)2.44371832
168positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.43733843
169endocardial cushion development (GO:0003197)2.38906810
170heart contraction (GO:0060047)2.38515487
171heart process (GO:0003015)2.38515487
172regulation of calcium ion transmembrane transport (GO:1903169)2.37579663
173regulation of calcium ion transmembrane transporter activity (GO:1901019)2.37579663
174cAMP catabolic process (GO:0006198)2.37330669
175positive regulation of sodium ion transmembrane transport (GO:1902307)2.36645163
176nephron tubule morphogenesis (GO:0072078)2.36423127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.61194307
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.75590557
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.98870115
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.30956878
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.24137444
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.21648611
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.58203361
8EZH2_22144423_ChIP-Seq_EOC_Human3.57293567
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.22101872
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.87779923
11VDR_22108803_ChIP-Seq_LS180_Human2.81411454
12ZNF274_21170338_ChIP-Seq_K562_Hela2.59131114
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57894424
14CLOCK_20551151_ChIP-Seq_293T_Human2.42607806
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39981880
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.30513173
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28610159
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17835051
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12978833
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03907087
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.97004344
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.90114197
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79426198
24TBX20_22080862_ChIP-Seq_HEART_Mouse1.77099220
25TBX20_22328084_ChIP-Seq_HEART_Mouse1.77099220
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70102118
27GATA1_22025678_ChIP-Seq_K562_Human1.68493005
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.62022177
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61837364
30ER_23166858_ChIP-Seq_MCF-7_Human1.58566391
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57714855
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.56369733
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53261361
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51947333
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51913088
36IGF1R_20145208_ChIP-Seq_DFB_Human1.49633151
37SMAD4_21799915_ChIP-Seq_A2780_Human1.49037225
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48709238
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46071413
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44102892
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43578934
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43550426
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.43305260
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.42082921
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.39944511
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.39864928
47STAT3_23295773_ChIP-Seq_U87_Human1.37697179
48TAF15_26573619_Chip-Seq_HEK293_Human1.36470114
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33036976
50TCF4_23295773_ChIP-Seq_U87_Human1.31267122
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31236039
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30364860
53ZNF263_19887448_ChIP-Seq_K562_Human1.30240363
54AR_25329375_ChIP-Seq_VCAP_Human1.29951839
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.29422477
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28379746
57* REST_21632747_ChIP-Seq_MESCs_Mouse1.28335242
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27207282
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.26344504
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25630309
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24009454
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23727295
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.22343555
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21295107
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20926059
66P300_19829295_ChIP-Seq_ESCs_Human1.20755251
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20713476
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19541704
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19540147
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.18383840
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17428525
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16444927
73RNF2_27304074_Chip-Seq_NSC_Mouse1.14299773
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13902663
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13036418
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12455356
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12152474
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11517266
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.11152845
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09396710
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08829041
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08381577
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08109187
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08109187
85TP53_16413492_ChIP-PET_HCT116_Human1.06983936
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.06921769
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.06377958
88RUNX2_22187159_ChIP-Seq_PCA_Human1.04747282
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.02453540
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02292036
91TCF4_22108803_ChIP-Seq_LS180_Human1.01867387
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01819565
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.98557026
94AR_21572438_ChIP-Seq_LNCaP_Human0.97051677
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96459442
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96050695
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95818970
98FUS_26573619_Chip-Seq_HEK293_Human0.95607208
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95603492
100PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94948527
101PIAS1_25552417_ChIP-Seq_VCAP_Human0.94113265
102BCAT_22108803_ChIP-Seq_LS180_Human0.94080173
103HTT_18923047_ChIP-ChIP_STHdh_Human0.92737095
104* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91904531
105FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91272305
106* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91238302
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91217843
108FLI1_21867929_ChIP-Seq_TH2_Mouse0.90605412
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89926986
110HNF4A_19822575_ChIP-Seq_HepG2_Human0.89913479
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87713715
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85348301
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85235730
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82075353
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81978849
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.81040071
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77088630
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76269398
119GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75891074
120SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75599668
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75563439
122MTF2_20144788_ChIP-Seq_MESCs_Mouse0.75542577
123GATA2_21666600_ChIP-Seq_HMVEC_Human0.75104990
124DROSHA_22980978_ChIP-Seq_HELA_Human0.74609583
125GBX2_23144817_ChIP-Seq_PC3_Human0.74586214
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73182825
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72302411
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.72102754
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71675386
130CJUN_26792858_Chip-Seq_BT549_Human0.71640802
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71350495
132CBP_21632823_ChIP-Seq_H3396_Human0.71156134
133SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70424430
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.68226664
135CTCF_27219007_Chip-Seq_Bcells_Human0.66870134
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65668637
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.64632565
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.63458289
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.63456934
140OCT4_20526341_ChIP-Seq_ESCs_Human0.63003447
141SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.62839286
142GATA4_25053715_ChIP-Seq_YYC3_Human0.61951812
143RNF2_18974828_ChIP-Seq_MESCs_Mouse0.61149600
144EZH2_18974828_ChIP-Seq_MESCs_Mouse0.61149600
145GATA1_19941826_ChIP-Seq_K562_Human0.60970652
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.60940195
147CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.59569998
148AHR_22903824_ChIP-Seq_MCF-7_Human0.59507885
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.59357999
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58993164
151FOXH1_21741376_ChIP-Seq_ESCs_Human0.58586304
152FOXA1_25552417_ChIP-Seq_VCAP_Human0.57549977
153P63_26484246_Chip-Seq_KERATINOCYTES_Human0.57236687
154KLF4_19829295_ChIP-Seq_ESCs_Human0.57073730
155TP63_22573176_ChIP-Seq_HFKS_Human0.56926045
156GATA2_19941826_ChIP-Seq_K562_Human0.55772568
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.55743151
158NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.54986963
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.54978945
160GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54757870
161SOX2_20726797_ChIP-Seq_SW620_Human0.53944458
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53763762
163SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.52831277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.35771013
2MP0002139_abnormal_hepatobiliary_system4.13477581
3MP0005670_abnormal_white_adipose3.98341713
4MP0004130_abnormal_muscle_cell3.57759100
5MP0005365_abnormal_bile_salt3.50410237
6MP0003646_muscle_fatigue3.45794464
7MP0005360_urolithiasis3.28520398
8MP0005085_abnormal_gallbladder_physiolo3.21944021
9MP0005666_abnormal_adipose_tissue2.98091236
10MP0000751_myopathy2.91634942
11MP0010329_abnormal_lipoprotein_level2.56092792
12MP0004084_abnormal_cardiac_muscle2.52968013
13MP0004215_abnormal_myocardial_fiber2.51809428
14MP0000749_muscle_degeneration2.39713233
15MP0004036_abnormal_muscle_relaxation2.39468316
16MP0008875_abnormal_xenobiotic_pharmacok2.38356210
17MP0005330_cardiomyopathy2.32283145
18MP0004185_abnormal_adipocyte_glucose2.26580724
19MP0005375_adipose_tissue_phenotype2.14507128
20MP0003195_calcinosis2.06968780
21MP0003806_abnormal_nucleotide_metabolis2.05310643
22MP0003252_abnormal_bile_duct2.04330460
23MP0002118_abnormal_lipid_homeostasis2.00242691
24MP0002971_abnormal_brown_adipose1.90611554
25MP0000013_abnormal_adipose_tissue1.88705542
26MP0006036_abnormal_mitochondrial_physio1.88651850
27MP0004087_abnormal_muscle_fiber1.86693814
28MP0002972_abnormal_cardiac_muscle1.76890899
29MP0005620_abnormal_muscle_contractility1.76846723
30MP0003122_maternal_imprinting1.76709358
31MP0005332_abnormal_amino_acid1.75811142
32MP0005083_abnormal_biliary_tract1.71373362
33MP0008775_abnormal_heart_ventricle1.64623382
34MP0003191_abnormal_cellular_cholesterol1.61765006
35MP0002269_muscular_atrophy1.58664471
36MP0002638_abnormal_pupillary_reflex1.58648813
37MP0009046_muscle_twitch1.53977098
38MP0000003_abnormal_adipose_tissue1.53376381
39MP0005385_cardiovascular_system_phenoty1.52856619
40MP0001544_abnormal_cardiovascular_syste1.52856619
41MP0006138_congestive_heart_failure1.52817405
42MP0005646_abnormal_pituitary_gland1.48694994
43MP0000750_abnormal_muscle_regeneration1.45925736
44MP0009840_abnormal_foam_cell1.45479178
45MP0002078_abnormal_glucose_homeostasis1.45270027
46MP0005535_abnormal_body_temperature1.44633024
47MP0005334_abnormal_fat_pad1.43532232
48MP0003137_abnormal_impulse_conducting1.43145406
49MP0000747_muscle_weakness1.41675295
50MP0000609_abnormal_liver_physiology1.41605954
51MP0004510_myositis1.40040357
52MP0004145_abnormal_muscle_electrophysio1.39830415
53MP0002106_abnormal_muscle_physiology1.38252880
54MP0000759_abnormal_skeletal_muscle1.35300338
55MP0008438_abnormal_cutaneous_collagen1.34660816
56MP0009745_abnormal_behavioral_response1.32202223
57MP0004043_abnormal_pH_regulation1.31975675
58MP0010630_abnormal_cardiac_muscle1.29153311
59MP0005319_abnormal_enzyme/_coenzyme1.28585498
60MP0005551_abnormal_eye_electrophysiolog1.27863134
61MP0003136_yellow_coat_color1.26534130
62MP0002876_abnormal_thyroid_physiology1.25832154
63MP0005386_behavior/neurological_phenoty1.24347174
64MP0004924_abnormal_behavior1.24347174
65MP0002272_abnormal_nervous_system1.24267713
66MP0004484_altered_response_of1.22131391
67MP0001666_abnormal_nutrient_absorption1.21948765
68MP0001984_abnormal_olfaction1.20504050
69MP0009780_abnormal_chondrocyte_physiolo1.20338459
70MP0004885_abnormal_endolymph1.20243203
71MP0005584_abnormal_enzyme/coenzyme_acti1.18558788
72MP0002909_abnormal_adrenal_gland1.18304058
73MP0005369_muscle_phenotype1.17751769
74MP0003221_abnormal_cardiomyocyte_apopto1.16121504
75MP0005187_abnormal_penis_morphology1.15924770
76MP0001661_extended_life_span1.10862261
77MP0003705_abnormal_hypodermis_morpholog1.10162368
78MP0004085_abnormal_heartbeat1.07868177
79MP0009115_abnormal_fat_cell1.05027440
80MP0003283_abnormal_digestive_organ1.04458820
81MP0005451_abnormal_body_composition1.04286034
82MP0002064_seizures1.03526216
83MP0005275_abnormal_skin_tensile0.99071148
84MP0005448_abnormal_energy_balance0.99030826
85MP0000230_abnormal_systemic_arterial0.98172914
86MP0002332_abnormal_exercise_endurance0.97378020
87MP0009643_abnormal_urine_homeostasis0.97300982
88MP0001529_abnormal_vocalization0.95537675
89MP0002234_abnormal_pharynx_morphology0.94376168
90MP0001486_abnormal_startle_reflex0.93501730
91MP0004142_abnormal_muscle_tone0.93234993
92MP0002970_abnormal_white_adipose0.92060717
93MP0000427_abnormal_hair_cycle0.91752830
94MP0001968_abnormal_touch/_nociception0.91286028
95MP0001764_abnormal_homeostasis0.90059998
96MP0003121_genomic_imprinting0.88326558
97MP0002572_abnormal_emotion/affect_behav0.88257814
98MP0006035_abnormal_mitochondrial_morpho0.87021507
99MP0003959_abnormal_lean_body0.86915964
100MP0003186_abnormal_redox_activity0.86253871
101MP0004233_abnormal_muscle_weight0.85811328
102MP0006276_abnormal_autonomic_nervous0.83596337
103MP0005423_abnormal_somatic_nervous0.82569220
104MP0001502_abnormal_circadian_rhythm0.81694199
105MP0005266_abnormal_metabolism0.81083750
106MP0003950_abnormal_plasma_membrane0.80658759
107MP0003828_pulmonary_edema0.80568852
108MP0002877_abnormal_melanocyte_morpholog0.78274406
109MP0006072_abnormal_retinal_apoptosis0.77867891
110MP0002108_abnormal_muscle_morphology0.77075507
111MP0003635_abnormal_synaptic_transmissio0.76392936
112MP0002063_abnormal_learning/memory/cond0.75459450
113MP0010368_abnormal_lymphatic_system0.74861686
114MP0004019_abnormal_vitamin_homeostasis0.74699913
115MP0005452_abnormal_adipose_tissue0.74477252
116MP0001501_abnormal_sleep_pattern0.73782773
117MP0003953_abnormal_hormone_level0.73389459
118MP0009384_cardiac_valve_regurgitation0.73252583
119MP0004133_heterotaxia0.72874346
120MP0002557_abnormal_social/conspecific_i0.72567533
121MP0008961_abnormal_basal_metabolism0.72280629
122MP0005645_abnormal_hypothalamus_physiol0.71962553
123MP0005253_abnormal_eye_physiology0.71941668
124MP0001970_abnormal_pain_threshold0.69460772
125MP0002938_white_spotting0.69340196
126MP0000372_irregular_coat_pigmentation0.68648837
127MP0001986_abnormal_taste_sensitivity0.67310532
128MP0003690_abnormal_glial_cell0.66491823
129MP0003329_amyloid_beta_deposits0.66425035
130MP0003787_abnormal_imprinting0.65634564
131MP0002067_abnormal_sensory_capabilities0.65546089
132MP0002160_abnormal_reproductive_system0.64460126
133MP0002138_abnormal_hepatobiliary_system0.64202749
134MP0002127_abnormal_cardiovascular_syste0.63958671
135MP0001756_abnormal_urination0.63943738
136MP0003567_abnormal_fetal_cardiomyocyte0.63140616
137MP0003868_abnormal_feces_composition0.60529267
138MP0004147_increased_porphyrin_level0.60322239
139MP0000343_altered_response_to0.60133256
140MP0009642_abnormal_blood_homeostasis0.57047092
141MP0005165_increased_susceptibility_to0.55494941
142MP0003011_delayed_dark_adaptation0.54761826
143MP0009697_abnormal_copulation0.54303180
144MP0001944_abnormal_pancreas_morphology0.54095941

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.99023475
2Myoglobinuria (HP:0002913)4.96540198
3Ketoacidosis (HP:0001993)4.64180717
4Exercise-induced myalgia (HP:0003738)4.41448425
5Ketosis (HP:0001946)4.38255437
6Hyperglycinuria (HP:0003108)4.25057991
7Sudden death (HP:0001699)4.21982129
8Abnormality of fatty-acid metabolism (HP:0004359)4.14323183
9Abnormality of serine family amino acid metabolism (HP:0010894)3.79206792
10Abnormality of glycine metabolism (HP:0010895)3.79206792
11Calf muscle hypertrophy (HP:0008981)3.76736938
12Rhabdomyolysis (HP:0003201)3.70101172
13Ventricular fibrillation (HP:0001663)3.69980071
14Hyperammonemia (HP:0001987)3.66231234
15Exercise-induced muscle cramps (HP:0003710)3.65064342
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.63485829
17Ventricular tachycardia (HP:0004756)3.59889372
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.59631123
19Dicarboxylic aciduria (HP:0003215)3.59631123
20Xanthomatosis (HP:0000991)3.59423719
21Left ventricular hypertrophy (HP:0001712)3.58648948
22Muscle hypertrophy of the lower extremities (HP:0008968)3.53806943
23Hyporeflexia of lower limbs (HP:0002600)3.48444825
24Muscle fiber splitting (HP:0003555)3.46534903
25Hypoalphalipoproteinemia (HP:0003233)3.39954315
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32926471
27Right ventricular cardiomyopathy (HP:0011663)3.32859037
28Hyperlipoproteinemia (HP:0010980)3.32053913
29Hyperinsulinemic hypoglycemia (HP:0000825)3.26473452
30Intrahepatic cholestasis (HP:0001406)3.16525332
31Palpitations (HP:0001962)3.13120422
32Lipoatrophy (HP:0100578)3.09769568
33Hepatic necrosis (HP:0002605)3.08035509
34Hyperglycinemia (HP:0002154)3.07736297
35Increased connective tissue (HP:0009025)3.03340330
36Oligomenorrhea (HP:0000876)2.99903519
37Difficulty running (HP:0009046)2.99013176
38Cerebral edema (HP:0002181)2.98778091
39Deep venous thrombosis (HP:0002625)2.94506467
40Epidermoid cyst (HP:0200040)2.94269700
41Atrial fibrillation (HP:0005110)2.92923278
42Hyperglycemia (HP:0003074)2.86584325
43Generalized aminoaciduria (HP:0002909)2.86544145
44Skin nodule (HP:0200036)2.85973825
45Abnormal EKG (HP:0003115)2.84891714
46Type II lissencephaly (HP:0007260)2.82954041
47Abnormality of the calf musculature (HP:0001430)2.82920117
48Hypoglycemic seizures (HP:0002173)2.82648076
49Insulin-resistant diabetes mellitus (HP:0000831)2.82393863
50Large for gestational age (HP:0001520)2.80194282
51Hypolipoproteinemia (HP:0010981)2.80134041
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.75484491
53Hyperventilation (HP:0002883)2.74346659
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73195104
55Abnormality of alanine metabolism (HP:0010916)2.73195104
56Hyperalaninemia (HP:0003348)2.73195104
57Dilated cardiomyopathy (HP:0001644)2.72896746
58Increased muscle lipid content (HP:0009058)2.70380411
59Primary atrial arrhythmia (HP:0001692)2.67758020
60Complement deficiency (HP:0004431)2.64826206
61Abnormality of the renal cortex (HP:0011035)2.61484618
62Syncope (HP:0001279)2.58481417
63Metabolic acidosis (HP:0001942)2.58450449
64Arthropathy (HP:0003040)2.58285853
65Acute encephalopathy (HP:0006846)2.56864078
66Bundle branch block (HP:0011710)2.54710907
67Prolonged partial thromboplastin time (HP:0003645)2.54638028
68Muscle stiffness (HP:0003552)2.53523114
69Asymmetric septal hypertrophy (HP:0001670)2.53156848
70Supraventricular tachycardia (HP:0004755)2.52875241
71Lethargy (HP:0001254)2.49195208
72Supraventricular arrhythmia (HP:0005115)2.49011740
73EMG: neuropathic changes (HP:0003445)2.48068868
74EMG: myopathic abnormalities (HP:0003458)2.43326374
75Atrioventricular block (HP:0001678)2.42335237
76Prominent supraorbital ridges (HP:0000336)2.36985364
77Heart block (HP:0012722)2.35849748
78Abnormal mitochondria in muscle tissue (HP:0008316)2.32945322
79Myotonia (HP:0002486)2.31421075
80Pheochromocytoma (HP:0002666)2.28646719
81Hypobetalipoproteinemia (HP:0003563)2.28572972
82Pancreatic cysts (HP:0001737)2.27849215
83Abnormal gallbladder morphology (HP:0012437)2.25789434
84Cholelithiasis (HP:0001081)2.25610536
85Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25514710
86Abnormal atrioventricular conduction (HP:0005150)2.24874039
87Ventricular arrhythmia (HP:0004308)2.24174998
88Abnormality of serum amino acid levels (HP:0003112)2.24089582
89Renal cortical cysts (HP:0000803)2.23242932
90Subaortic stenosis (HP:0001682)2.22910940
91Abnormality of the left ventricular outflow tract (HP:0011103)2.22910940
92Acute necrotizing encephalopathy (HP:0006965)2.20593384
93Acanthosis nigricans (HP:0000956)2.19902225
94Hepatocellular necrosis (HP:0001404)2.19257217
95Prolonged QT interval (HP:0001657)2.19191204
96Vomiting (HP:0002013)2.17300218
97Late onset (HP:0003584)2.16337007
98Conjunctival hamartoma (HP:0100780)2.16053585
99Tubular atrophy (HP:0000092)2.15731796
100Type 1 muscle fiber predominance (HP:0003803)2.14541513
101Proximal tubulopathy (HP:0000114)2.12275464
102Hypertriglyceridemia (HP:0002155)2.10113737
103Abnormality of purine metabolism (HP:0004352)2.10033826
104Lactic acidosis (HP:0003128)2.10013133
105Increased variability in muscle fiber diameter (HP:0003557)2.09538104
106Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08840096
107Abnormality of the intrinsic pathway (HP:0010989)2.08243620
108Abnormality of glycolysis (HP:0004366)2.05644570
109Increased serum pyruvate (HP:0003542)2.05644570
110Nephronophthisis (HP:0000090)2.02886198
111Gout (HP:0001997)2.02302491
112Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01299616
113Nausea (HP:0002018)2.00751843
114Pancreatic islet-cell hyperplasia (HP:0004510)2.00313006
115Symptomatic seizures (HP:0011145)1.99276826
116Frequent falls (HP:0002359)1.98930008
117Insulin resistance (HP:0000855)1.97802395
118Distal lower limb muscle weakness (HP:0009053)1.95147411
119Bradycardia (HP:0001662)1.94584465
120Pancreatic fibrosis (HP:0100732)1.93383426
121Pachygyria (HP:0001302)1.92855259
122True hermaphroditism (HP:0010459)1.92371034
123Abnormality of the renal medulla (HP:0100957)1.92297409
124Muscular dystrophy (HP:0003560)1.92255737
125Decreased circulating renin level (HP:0003351)1.88471774
126Congenital stationary night blindness (HP:0007642)1.86922517
127Concave nail (HP:0001598)1.85556047
128Rimmed vacuoles (HP:0003805)1.84666739
129Abnormality of midbrain morphology (HP:0002418)1.79031978
130Molar tooth sign on MRI (HP:0002419)1.79031978
131Severe muscular hypotonia (HP:0006829)1.77310845
132Medial flaring of the eyebrow (HP:0010747)1.75993655
133Cerebellar dysplasia (HP:0007033)1.75787850
134Abnormal drinking behavior (HP:0030082)1.75754487
135Polydipsia (HP:0001959)1.75754487
136Broad-based gait (HP:0002136)1.72759947
137Focal seizures (HP:0007359)1.68483999
138Sudden cardiac death (HP:0001645)1.63765494
139Generalized muscle weakness (HP:0003324)1.63658836
140Congenital, generalized hypertrichosis (HP:0004540)1.62089153
141Palmoplantar keratoderma (HP:0000982)1.61765987
142Progressive cerebellar ataxia (HP:0002073)1.60791066
143Areflexia of lower limbs (HP:0002522)1.59525224
144Infantile muscular hypotonia (HP:0008947)1.59130271
145Cystic liver disease (HP:0006706)1.59074103
146Gaze-evoked nystagmus (HP:0000640)1.57354866
147Lissencephaly (HP:0001339)1.56996166
148Anxiety (HP:0000739)1.56943269
149Inability to walk (HP:0002540)1.56912973
150Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56668013
151Gait imbalance (HP:0002141)1.56619444
152Hemiparesis (HP:0001269)1.56298284
153Testicular atrophy (HP:0000029)1.55541943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.28110449
2TTN3.48570606
3INSRR3.36667890
4PDK43.33964738
5PDK33.33964738
6TRIB33.14923980
7OBSCN3.13947977
8PHKG13.11106347
9PHKG23.11106347
10LMTK23.05687541
11MARK12.64110235
12SIK12.54458429
13PINK12.25244559
14ADRBK22.18829368
15BMPR1B2.02904635
16CAMK1D1.98005333
17PKN21.96487520
18PDK21.93644118
19CASK1.85761789
20MAP4K21.83488382
21MYLK1.80084306
22PIK3CA1.79155099
23ERN11.77635578
24LIMK11.75806184
25TIE11.54582060
26PRKAA21.44443109
27WNK41.42786047
28CAMK1G1.42775912
29ACVR1B1.42641614
30NTRK31.38085311
31FGFR41.30301285
32GRK11.29566926
33RIPK11.23603936
34MUSK1.21077478
35MAPK131.20619098
36PAK31.17477480
37MAP2K41.15260268
38PRKAA11.14732064
39FLT31.14521985
40ADRBK11.12061625
41PIK3CG1.11566401
42DMPK1.07602423
43FGFR21.07097251
44NTRK21.02034549
45CAMKK20.98510642
46AKT30.93732987
47FRK0.92747318
48PRKD10.91183023
49MST1R0.89602800
50CAMK2D0.88338897
51MAP3K70.88318887
52PNCK0.86348377
53NEK90.86106448
54PDGFRA0.83464309
55GRK70.82866517
56MAPK120.82463901
57LATS10.81862753
58MAP2K60.77116662
59STK38L0.76633636
60PRKD30.75930750
61NEK10.74566331
62MAP2K10.74206755
63PDPK10.73280233
64PRKACG0.72796258
65PRKCG0.72523841
66WNK30.71219601
67EPHB10.70291871
68MAP2K20.69980532
69MAP2K30.69601471
70WNK10.64449989
71STK110.64337976
72TLK10.64280386
73FER0.64119211
74CAMK2B0.62663554
75MAP3K30.62274809
76TAOK30.62138561
77STK390.62002592
78OXSR10.61692501
79PRKCH0.61429949
80RET0.61294086
81PKN10.60922234
82MET0.60781252
83ERBB40.59966917
84CDC42BPA0.55488625
85TYRO30.54580592
86MAPK110.54444939
87CAMK2G0.53424989
88EPHA20.52284625
89PRKCE0.51711294
90PRKACA0.50650304
91ZAK0.50393964
92SGK30.50166492
93ROCK10.48638815
94PRKG10.48551468
95DYRK20.48089813
96DAPK20.47994403
97JAK10.47473231
98TGFBR10.47380119
99RPS6KA60.46840747
100PDK10.46557700
101MAP3K50.46101668
102MAP2K70.45329096
103JAK20.44756753
104FGFR30.44675349
105SGK2230.44338937
106SGK4940.44338937
107EPHB20.44245973
108CAMK2A0.43874596
109EPHA30.43091355
110MAP3K60.42614563
111TRPM70.41794615
112STK240.41358773
113MAPK150.41134889
114MAP3K40.40464144
115IRAK10.40367119
116PTK60.40340889
117ABL20.38896342
118EPHA40.38537484
119NLK0.37887702
120CAMK10.37670822
121SGK20.36914131
122MAPKAPK30.36310766
123RPS6KA30.36183695
124CAMK40.35804577
125MAP3K10.35776931
126PTK2B0.35419101
127ROCK20.35030032
128GSK3A0.34699904
129PAK60.33894226
130NTRK10.33618906
131TNIK0.33455814
132PRKACB0.33224171
133PLK20.33190373
134LATS20.32474504
135IRAK20.32209546
136MAP3K20.32188497
137STK380.30771251
138FES0.30632129
139PRKCZ0.30192463
140PRKCA0.28931641
141NUAK10.28251160
142CDK50.26213098

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.70231351
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.69319168
3Fatty acid degradation_Homo sapiens_hsa000713.45870056
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.43217283
5Fatty acid metabolism_Homo sapiens_hsa012123.02791550
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.02259403
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61631383
8PPAR signaling pathway_Homo sapiens_hsa033202.58018464
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46679004
10Butanoate metabolism_Homo sapiens_hsa006502.39391103
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.36029139
12Tryptophan metabolism_Homo sapiens_hsa003802.24200150
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18113995
14Pyruvate metabolism_Homo sapiens_hsa006202.13496414
15Fatty acid elongation_Homo sapiens_hsa000622.09940053
16Carbon metabolism_Homo sapiens_hsa012001.96782430
17Nitrogen metabolism_Homo sapiens_hsa009101.96321439
18Peroxisome_Homo sapiens_hsa041461.91099676
19beta-Alanine metabolism_Homo sapiens_hsa004101.85663978
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83263731
21Arginine biosynthesis_Homo sapiens_hsa002201.82921959
22Fatty acid biosynthesis_Homo sapiens_hsa000611.78417563
23Phenylalanine metabolism_Homo sapiens_hsa003601.47869578
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47421594
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46576790
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38227711
27Starch and sucrose metabolism_Homo sapiens_hsa005001.36744521
28Sulfur metabolism_Homo sapiens_hsa009201.31801443
29Caffeine metabolism_Homo sapiens_hsa002321.27520307
30Tyrosine metabolism_Homo sapiens_hsa003501.22582806
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19689311
32Complement and coagulation cascades_Homo sapiens_hsa046101.19626774
33Oxidative phosphorylation_Homo sapiens_hsa001901.17879224
34Fat digestion and absorption_Homo sapiens_hsa049751.17570405
35Glycerolipid metabolism_Homo sapiens_hsa005611.16614300
36Cardiac muscle contraction_Homo sapiens_hsa042601.15619756
37GABAergic synapse_Homo sapiens_hsa047271.14446521
38Phototransduction_Homo sapiens_hsa047441.14409968
39Ether lipid metabolism_Homo sapiens_hsa005651.13502341
40Circadian entrainment_Homo sapiens_hsa047131.13204676
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.11890727
42Morphine addiction_Homo sapiens_hsa050321.11020569
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09609665
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09426206
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09000091
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05980922
47Parkinsons disease_Homo sapiens_hsa050121.05600063
48Biosynthesis of amino acids_Homo sapiens_hsa012301.04890579
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02020113
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.00314766
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00306990
52Nicotine addiction_Homo sapiens_hsa050330.99686713
53Histidine metabolism_Homo sapiens_hsa003400.99678067
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99016422
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97289796
56Chemical carcinogenesis_Homo sapiens_hsa052040.95650587
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94072770
58ABC transporters_Homo sapiens_hsa020100.92176567
59Dilated cardiomyopathy_Homo sapiens_hsa054140.91836698
60Gastric acid secretion_Homo sapiens_hsa049710.89988605
61Insulin resistance_Homo sapiens_hsa049310.88925090
62Glutamatergic synapse_Homo sapiens_hsa047240.88607024
63Taste transduction_Homo sapiens_hsa047420.88172308
64Bile secretion_Homo sapiens_hsa049760.87713871
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86392283
66Alzheimers disease_Homo sapiens_hsa050100.85312680
67Glucagon signaling pathway_Homo sapiens_hsa049220.82924226
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82841967
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82429018
70Salivary secretion_Homo sapiens_hsa049700.82032245
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81872263
72Arginine and proline metabolism_Homo sapiens_hsa003300.80950521
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80700989
74Oxytocin signaling pathway_Homo sapiens_hsa049210.80410255
75Lysine degradation_Homo sapiens_hsa003100.79337295
76Retinol metabolism_Homo sapiens_hsa008300.79115200
77AMPK signaling pathway_Homo sapiens_hsa041520.76397559
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.76093512
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73739521
80Cocaine addiction_Homo sapiens_hsa050300.73520321
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72888778
82cAMP signaling pathway_Homo sapiens_hsa040240.72653879
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71002433
84Selenocompound metabolism_Homo sapiens_hsa004500.69432531
85Dopaminergic synapse_Homo sapiens_hsa047280.68290769
86Thyroid hormone synthesis_Homo sapiens_hsa049180.67806990
87Amphetamine addiction_Homo sapiens_hsa050310.67360078
88Insulin signaling pathway_Homo sapiens_hsa049100.65375555
89Serotonergic synapse_Homo sapiens_hsa047260.62219627
90Mineral absorption_Homo sapiens_hsa049780.61852187
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.61113863
92Arachidonic acid metabolism_Homo sapiens_hsa005900.59880106
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.59808789
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59769353
95Pancreatic secretion_Homo sapiens_hsa049720.58388710
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57119736
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56727451
98Vitamin B6 metabolism_Homo sapiens_hsa007500.55892460
99Olfactory transduction_Homo sapiens_hsa047400.55304044
100Staphylococcus aureus infection_Homo sapiens_hsa051500.55088790
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54911424
102Metabolic pathways_Homo sapiens_hsa011000.49903215
103Fructose and mannose metabolism_Homo sapiens_hsa000510.47976671
104Type II diabetes mellitus_Homo sapiens_hsa049300.47532192
105Folate biosynthesis_Homo sapiens_hsa007900.46181260
106Huntingtons disease_Homo sapiens_hsa050160.44983158
107Galactose metabolism_Homo sapiens_hsa000520.44383463
108Steroid biosynthesis_Homo sapiens_hsa001000.41047463
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40009289
110Sulfur relay system_Homo sapiens_hsa041220.38664863
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38351048
112Pentose phosphate pathway_Homo sapiens_hsa000300.38251687
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.36075655
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35139239
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30114950
116Insulin secretion_Homo sapiens_hsa049110.27125181
117Linoleic acid metabolism_Homo sapiens_hsa005910.26553079
118Glutathione metabolism_Homo sapiens_hsa004800.24002996
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23223733
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22419571
121Circadian rhythm_Homo sapiens_hsa047100.21835399
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18819735
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18313922
124Vitamin digestion and absorption_Homo sapiens_hsa049770.18240403
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.17556893
126Renin secretion_Homo sapiens_hsa049240.15697431
127Ovarian steroidogenesis_Homo sapiens_hsa049130.12213432
128Prion diseases_Homo sapiens_hsa050200.07716348
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.07426734
130Calcium signaling pathway_Homo sapiens_hsa040200.02641623

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