FIZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.59154870
2regulation of chromatin binding (GO:0035561)4.55815042
3DNA unwinding involved in DNA replication (GO:0006268)4.52218042
4DNA replication initiation (GO:0006270)4.47641318
5DNA strand elongation involved in DNA replication (GO:0006271)4.47349915
6protein localization to kinetochore (GO:0034501)4.44982710
7planar cell polarity pathway involved in neural tube closure (GO:0090179)4.30802446
8DNA strand elongation (GO:0022616)4.27503549
9DNA deamination (GO:0045006)4.23485228
10apoptotic process involved in morphogenesis (GO:0060561)4.13912920
11DNA replication checkpoint (GO:0000076)4.11199804
12formation of translation preinitiation complex (GO:0001731)4.06521293
13mitotic metaphase plate congression (GO:0007080)3.97759319
14protein localization to chromosome, centromeric region (GO:0071459)3.92474894
15folic acid-containing compound biosynthetic process (GO:0009396)3.86386760
16telomere maintenance via semi-conservative replication (GO:0032201)3.86212349
17intracellular estrogen receptor signaling pathway (GO:0030520)3.85307469
18negative regulation of cell size (GO:0045792)3.84734763
19activation of MAPKKK activity (GO:0000185)3.83290012
20nucleobase biosynthetic process (GO:0046112)3.81961322
21mitotic nuclear envelope disassembly (GO:0007077)3.76663483
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75480185
23CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.73527473
24DNA replication-dependent nucleosome organization (GO:0034723)3.73293387
25DNA replication-dependent nucleosome assembly (GO:0006335)3.73293387
26mannose metabolic process (GO:0006013)3.68737531
27maturation of SSU-rRNA (GO:0030490)3.67846380
28ribosome biogenesis (GO:0042254)3.66953825
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.64413428
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57744466
31purine nucleobase biosynthetic process (GO:0009113)3.57458048
32regulation of mammary gland epithelial cell proliferation (GO:0033599)3.56712376
33mitotic sister chromatid segregation (GO:0000070)3.49608562
34activation of Rac GTPase activity (GO:0032863)3.46726343
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.46189429
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.45548851
37nuclear envelope disassembly (GO:0051081)3.43650739
38membrane disassembly (GO:0030397)3.43650739
39positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.40504819
40nuclear pore organization (GO:0006999)3.39081689
41metaphase plate congression (GO:0051310)3.35700829
42telomere maintenance via recombination (GO:0000722)3.33377419
43positive regulation of histone deacetylation (GO:0031065)3.29591796
44DNA damage response, signal transduction resulting in transcription (GO:0042772)3.29334774
45ribosome assembly (GO:0042255)3.26471926
46nuclear pore complex assembly (GO:0051292)3.26174668
47maternal placenta development (GO:0001893)3.25726236
48IMP biosynthetic process (GO:0006188)3.25577325
49cell migration in hindbrain (GO:0021535)3.24530244
50modulation by virus of host process (GO:0019054)3.24129708
51modulation by symbiont of host cellular process (GO:0044068)3.23429282
52GDP-mannose metabolic process (GO:0019673)3.23054775
53cellular response to virus (GO:0098586)3.22696159
54telomere maintenance via telomere lengthening (GO:0010833)3.22319701
55regulation of gene silencing by RNA (GO:0060966)3.22191425
56regulation of posttranscriptional gene silencing (GO:0060147)3.22191425
57regulation of gene silencing by miRNA (GO:0060964)3.22191425
58ribonucleoprotein complex biogenesis (GO:0022613)3.20800805
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.20505449
60mitotic chromosome condensation (GO:0007076)3.19525783
61regulation of glucose import in response to insulin stimulus (GO:2001273)3.19380496
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18891448
63DNA duplex unwinding (GO:0032508)3.18388843
64heterochromatin organization (GO:0070828)3.16787292
65mitotic recombination (GO:0006312)3.15203125
66DNA geometric change (GO:0032392)3.15160493
67DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.14099197
68regulation of NFAT protein import into nucleus (GO:0051532)3.13866032
69stress fiber assembly (GO:0043149)3.10696714
70positive regulation of synapse maturation (GO:0090129)3.08315285
71spliceosomal snRNP assembly (GO:0000387)3.08283065
72regulation of telomere maintenance via telomerase (GO:0032210)3.07615823
73protein complex localization (GO:0031503)3.07295637
74regulation of early endosome to late endosome transport (GO:2000641)3.05958529
75cell-substrate adherens junction assembly (GO:0007045)3.05656344
76focal adhesion assembly (GO:0048041)3.05656344
77regulation of spindle organization (GO:0090224)3.05046932
78sister chromatid segregation (GO:0000819)3.04596814
79ribosomal small subunit biogenesis (GO:0042274)3.02319667
80folic acid metabolic process (GO:0046655)3.01754276
81pre-miRNA processing (GO:0031054)3.01711177
82negative regulation of viral release from host cell (GO:1902187)3.01082809
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00586959
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.00586959
85rRNA processing (GO:0006364)3.00088119
86regulation of ARF GTPase activity (GO:0032312)2.99443113
87viral transcription (GO:0019083)2.99405125
88translational initiation (GO:0006413)2.97925594
89IMP metabolic process (GO:0046040)2.97825873
90negative regulation of chromosome segregation (GO:0051985)2.97726816
91regulation of double-strand break repair via homologous recombination (GO:0010569)2.97646786
92regulation of podosome assembly (GO:0071801)2.96909888
93negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.96235015
94negative regulation of DNA-templated transcription, elongation (GO:0032785)2.96235015
95protein localization to chromosome (GO:0034502)2.95014064
96dosage compensation (GO:0007549)2.94667918
97adherens junction assembly (GO:0034333)2.93932243
98rRNA metabolic process (GO:0016072)2.93342639
99translational termination (GO:0006415)2.93062621
100rRNA modification (GO:0000154)2.93000198
101establishment of chromosome localization (GO:0051303)2.92851187
102regulation of chromosome segregation (GO:0051983)2.92555516
103maturation of 5.8S rRNA (GO:0000460)2.91782177
104negative regulation of RNA splicing (GO:0033119)2.91416358
105pseudouridine synthesis (GO:0001522)2.91062124
106signal complex assembly (GO:0007172)2.89702556
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.87684318
108ribosomal small subunit assembly (GO:0000028)2.87339407
109negative regulation of mitotic sister chromatid separation (GO:2000816)2.87315182
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87315182
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87315182
112negative regulation of sister chromatid segregation (GO:0033046)2.87315182
113peptidyl-arginine omega-N-methylation (GO:0035247)2.86848155
114DNA replication-independent nucleosome organization (GO:0034724)2.86379932
115DNA replication-independent nucleosome assembly (GO:0006336)2.86379932
116regulation of telomerase activity (GO:0051972)2.86133565
117regulation of apoptotic process involved in morphogenesis (GO:1902337)2.86054732
118chromatin remodeling at centromere (GO:0031055)2.85664596
119negative regulation of histone methylation (GO:0031061)2.85240606
120histone arginine methylation (GO:0034969)2.84930981
121semaphorin-plexin signaling pathway (GO:0071526)2.84835348
122translational elongation (GO:0006414)2.81508299
123mitochondrial DNA metabolic process (GO:0032042)2.80887090
124base-excision repair (GO:0006284)2.80587811
125mitotic spindle assembly checkpoint (GO:0007094)2.80585682
126histone H2A acetylation (GO:0043968)2.80443506
127spindle assembly checkpoint (GO:0071173)2.79902512
128chromatin assembly or disassembly (GO:0006333)2.79778495
129apoptotic process involved in development (GO:1902742)2.79511546
130positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.79392803
131protein K6-linked ubiquitination (GO:0085020)2.79315935
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79303845
133modulation by virus of host morphology or physiology (GO:0019048)2.78838881
134cell-cell junction maintenance (GO:0045217)2.78800888
135attachment of spindle microtubules to kinetochore (GO:0008608)2.78277335
136endothelial cell chemotaxis (GO:0035767)2.78122230
137spindle checkpoint (GO:0031577)2.77779280
138CENP-A containing nucleosome assembly (GO:0034080)2.77450080
139regulation of translation in response to stress (GO:0043555)2.76996129
140nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.76658060
141nuclear envelope organization (GO:0006998)2.76429801
142T cell lineage commitment (GO:0002360)2.75963944
143adenosine receptor signaling pathway (GO:0001973)2.75380167
144regulation of monocyte differentiation (GO:0045655)2.74986288
1453-UTR-mediated mRNA stabilization (GO:0070935)2.74949029
146negative regulation of mRNA processing (GO:0050686)2.74892854
147positive regulation of protein deacetylation (GO:0090312)2.74119209
148cellular protein complex localization (GO:0034629)2.73383110
149positive regulation of protein dephosphorylation (GO:0035307)2.71428757
150NIK/NF-kappaB signaling (GO:0038061)2.67383348
151positive regulation of isotype switching (GO:0045830)2.66297185
152histone H4 deacetylation (GO:0070933)2.65924143
153positive regulation of Cdc42 GTPase activity (GO:0043089)2.62866167
154regulation of histone H3-K27 methylation (GO:0061085)2.62053135
155osteoblast development (GO:0002076)2.61887638
156pentose-phosphate shunt (GO:0006098)2.61840893
157convergent extension (GO:0060026)2.61441725
158glucose 6-phosphate metabolic process (GO:0051156)2.57517979
159diaphragm development (GO:0060539)2.56675610
160atrioventricular valve morphogenesis (GO:0003181)2.56405514
161vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.56292542
162negative regulation of B cell apoptotic process (GO:0002903)2.56002775
163protein retention in ER lumen (GO:0006621)2.55248826
164skeletal muscle organ development (GO:0060538)2.54168813
165response to peptidoglycan (GO:0032494)2.54014585
166negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.53963722
167proline biosynthetic process (GO:0006561)2.53309966
168positive regulation of CREB transcription factor activity (GO:0032793)2.53290638
169regulation of ARF protein signal transduction (GO:0032012)2.52904525
170positive regulation of triglyceride biosynthetic process (GO:0010867)2.52774682
171G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.51504942
172Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50008297
173negative regulation of fatty acid transport (GO:2000192)2.48685546
174regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48619030
175regulation of fatty acid beta-oxidation (GO:0031998)2.44660037
176protein localization to endosome (GO:0036010)2.44474785
177regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.43960374
178regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.42534714
179regulation of cholesterol homeostasis (GO:2000188)2.40027355
180response to parathyroid hormone (GO:0071107)2.39410571
181intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.36990298
182positive regulation of blood vessel endothelial cell migration (GO:0043536)2.36340123
183response to muramyl dipeptide (GO:0032495)2.36238235
184positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.35127868
185negative regulation of toll-like receptor signaling pathway (GO:0034122)2.33834629
186negative regulation of telomerase activity (GO:0051974)2.33049425
187RNA stabilization (GO:0043489)2.31182305
188mRNA stabilization (GO:0048255)2.31182305
189positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.30466610
190positive regulation of DNA biosynthetic process (GO:2000573)2.30129953
191cytoskeletal anchoring at plasma membrane (GO:0007016)2.29988705
192UV protection (GO:0009650)2.28101297
193thymic T cell selection (GO:0045061)2.25767064
194positive regulation of gene expression, epigenetic (GO:0045815)2.25004794
195protein-DNA complex disassembly (GO:0032986)2.23700972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.60752547
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.81735495
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.71919091
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34321779
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.22099008
6LXR_22292898_ChIP-Seq_THP-1_Human2.99267744
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95187340
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90717432
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79430012
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.74031211
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.61524473
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58956327
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54413561
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.42791769
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.37138885
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.29243824
17KDM2B_26808549_Chip-Seq_DND41_Human2.28706951
18RACK7_27058665_Chip-Seq_MCF-7_Human2.28630018
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28501947
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26977257
21MYC_22102868_ChIP-Seq_BL_Human2.25904197
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23842856
23XRN2_22483619_ChIP-Seq_HELA_Human2.22014603
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.17921117
25TCF7_22412390_ChIP-Seq_EML_Mouse2.14008769
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10008002
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09408391
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05569934
29KDM2B_26808549_Chip-Seq_K562_Human2.01315337
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.00824893
31* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97201665
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95655021
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94158772
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91565857
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.90076034
36P68_20966046_ChIP-Seq_HELA_Human1.89745275
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86306556
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84700174
39* GABP_19822575_ChIP-Seq_HepG2_Human1.80526030
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79911227
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.78967963
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78477970
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77477698
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76697125
45* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76170923
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.76132276
47* CIITA_25753668_ChIP-Seq_RAJI_Human1.75175761
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73835408
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73767780
50ZNF263_19887448_ChIP-Seq_K562_Human1.72505795
51VDR_23849224_ChIP-Seq_CD4+_Human1.71819132
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71272220
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.71064184
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70897367
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.70178562
56VDR_24763502_ChIP-Seq_THP-1_Human1.68957145
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.68423462
58AR_21909140_ChIP-Seq_LNCAP_Human1.67750516
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67305686
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65883101
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.64431563
62CREB1_26743006_Chip-Seq_LNCaP_Human1.63941131
63* FOXP3_21729870_ChIP-Seq_TREG_Human1.62435446
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59734756
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58685487
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.58549708
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55320467
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.55209214
69MAF_26560356_Chip-Seq_TH1_Human1.54935323
70TTF2_22483619_ChIP-Seq_HELA_Human1.54099373
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53426455
72SMC4_20622854_ChIP-Seq_HELA_Human1.52362457
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50970944
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50297429
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48821668
76DCP1A_22483619_ChIP-Seq_HELA_Human1.48738754
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46825430
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46278977
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.45942464
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45340793
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.45124751
82VDR_21846776_ChIP-Seq_THP-1_Human1.43961337
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43563885
84KDM5A_27292631_Chip-Seq_BREAST_Human1.43356011
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43024771
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42932119
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41912897
88MAF_26560356_Chip-Seq_TH2_Human1.41001909
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40838261
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38496353
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37919012
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37563487
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.35041375
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34195126
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34122805
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33192470
97CTCF_27219007_Chip-Seq_Bcells_Human1.32372835
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31929993
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31391535
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30135753
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30135753
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30135753
103UTX_26944678_Chip-Seq_JUKART_Human1.29293806
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29235096
105NCOR1_26117541_ChIP-Seq_K562_Human1.28934162
106TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27484637
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26845508
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26785784
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26108399
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25428336
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25014832
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21961649
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21650631
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21356418
115BCOR_27268052_Chip-Seq_Bcells_Human1.19799775
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19498119
117* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17775631
118* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16519237
119* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16324681
120* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16032409
121* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15238469
122NOTCH1_21737748_ChIP-Seq_TLL_Human1.14602313
123ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13751561
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13682281
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12932654
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12611795
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12508730
128P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11876103
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11778436
130RUNX1_22412390_ChIP-Seq_EML_Mouse1.11261530
131* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10936278
132TP53_22127205_ChIP-Seq_IMR90_Human1.10811417
133BCL6_27268052_Chip-Seq_Bcells_Human1.10643902
134ATF3_27146783_Chip-Seq_COLON_Human1.09930021
135TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09202100
136NANOG_21062744_ChIP-ChIP_HESCs_Human1.08479465
137RUNX1_27514584_Chip-Seq_MCF-7_Human1.07871154
138* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06912325
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06696391
140ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06277361
141SA1_27219007_Chip-Seq_Bcells_Human1.06207616
142CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05969834
143STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05880147
144PHF8_20622854_ChIP-Seq_HELA_Human1.05309727
145CTCF_26484167_Chip-Seq_Bcells_Mouse1.05243937
146CTCF_21964334_Chip-Seq_Bcells_Human1.05068395
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04718588
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04218924
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03354344
150VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03187647
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03151730
152SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02870619
153TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02784707
154CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02532812
155RARA_24833708_ChIP-Seq_LIVER_Mouse1.02445763
156PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02171385
157HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02004471
158GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01928347
159TFEB_21752829_ChIP-Seq_HELA_Human1.01504702
160PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01442604
161SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00963439
162E2F1_20622854_ChIP-Seq_HELA_Human0.99303248
163OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98288398
164IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98124677
165SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97477045
166RARB_24833708_ChIP-Seq_LIVER_Mouse0.97297594
167* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97173983
168POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96576069
169GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95128760
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95120857
171MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93506034
172SRF_21415370_ChIP-Seq_HL-1_Mouse0.93199202
173NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91471767
174SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91148957
175SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90480968
176SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89877195
177TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86688171
178NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86396632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.92159776
2MP0004957_abnormal_blastocyst_morpholog4.04539506
3MP0003111_abnormal_nucleus_morphology3.92359046
4MP0010094_abnormal_chromosome_stability3.76996591
5MP0003077_abnormal_cell_cycle3.58822353
6MP0001348_abnormal_lacrimal_gland3.45360867
7MP0008057_abnormal_DNA_replication3.10213851
8MP0005058_abnormal_lysosome_morphology2.70283984
9MP0002653_abnormal_ependyma_morphology2.57073806
10MP0008058_abnormal_DNA_repair2.55026841
11MP0008007_abnormal_cellular_replicative2.52514546
12MP0000566_synostosis2.52225802
13MP0008932_abnormal_embryonic_tissue2.35161802
14MP0001730_embryonic_growth_arrest2.35010473
15MP0010352_gastrointestinal_tract_polyps2.34436733
16MP0010030_abnormal_orbit_morphology2.32589580
17MP0000350_abnormal_cell_proliferation2.23124336
18MP0003303_peritoneal_inflammation2.22911538
19MP0003283_abnormal_digestive_organ2.15291520
20MP0003172_abnormal_lysosome_physiology2.11288292
21MP0003300_gastrointestinal_ulcer2.09452575
22MP0004510_myositis2.07144377
23MP0002396_abnormal_hematopoietic_system2.05057143
24MP0000490_abnormal_crypts_of2.01541398
25MP0002822_catalepsy2.01196772
26MP0003123_paternal_imprinting1.99416854
27MP0008260_abnormal_autophagy1.96053978
28MP0005380_embryogenesis_phenotype1.93610353
29MP0001672_abnormal_embryogenesis/_devel1.93610353
30MP0003436_decreased_susceptibility_to1.86152839
31MP0001697_abnormal_embryo_size1.85944965
32MP0002085_abnormal_embryonic_tissue1.81322319
33MP0004858_abnormal_nervous_system1.75573062
34MP0003984_embryonic_growth_retardation1.75501025
35MP0002084_abnormal_developmental_patter1.72388579
36MP0002088_abnormal_embryonic_growth/wei1.71181871
37MP0006292_abnormal_olfactory_placode1.69848399
38MP0002089_abnormal_postnatal_growth/wei1.68333125
39MP0002080_prenatal_lethality1.61058203
40MP0003453_abnormal_keratinocyte_physiol1.60745447
41MP0003786_premature_aging1.59382357
42MP0009379_abnormal_foot_pigmentation1.53911064
43MP0002086_abnormal_extraembryonic_tissu1.53665810
44MP0005409_darkened_coat_color1.48206460
45MP0003718_maternal_effect1.47209611
46MP0010307_abnormal_tumor_latency1.46572396
47MP0003890_abnormal_embryonic-extraembry1.45367465
48MP0000313_abnormal_cell_death1.44678718
49MP0005666_abnormal_adipose_tissue1.44272620
50MP0004859_abnormal_synaptic_plasticity1.43992464
51MP0002019_abnormal_tumor_incidence1.41066951
52MP0004197_abnormal_fetal_growth/weight/1.40279891
53MP0005076_abnormal_cell_differentiation1.40188191
54MP0003119_abnormal_digestive_system1.38935884
55MP0001293_anophthalmia1.35365017
56MP0005397_hematopoietic_system_phenotyp1.33604895
57MP0001545_abnormal_hematopoietic_system1.33604895
58MP0008877_abnormal_DNA_methylation1.31457183
59MP0009333_abnormal_splenocyte_physiolog1.30358208
60MP0000003_abnormal_adipose_tissue1.29450410
61MP0005375_adipose_tissue_phenotype1.28754926
62MP0008789_abnormal_olfactory_epithelium1.28391746
63MP0004233_abnormal_muscle_weight1.27997418
64MP0000747_muscle_weakness1.24970027
65MP0003763_abnormal_thymus_physiology1.23738982
66MP0009278_abnormal_bone_marrow1.23367291
67MP0002210_abnormal_sex_determination1.21202516
68MP0002249_abnormal_larynx_morphology1.16032187
69MP0004808_abnormal_hematopoietic_stem1.14741590
70MP0003191_abnormal_cellular_cholesterol1.14725385
71MP0000751_myopathy1.14713825
72MP0003121_genomic_imprinting1.13659412
73MP0000604_amyloidosis1.13194055
74MP0001853_heart_inflammation1.10893152
75MP0001145_abnormal_male_reproductive1.10638314
76MP0004381_abnormal_hair_follicle1.09234017
77MP0000759_abnormal_skeletal_muscle1.08616338
78MP0005257_abnormal_intraocular_pressure1.08277666
79MP0000750_abnormal_muscle_regeneration1.05999228
80MP0001849_ear_inflammation1.05600598
81MP0000703_abnormal_thymus_morphology1.05167318
82MP0000681_abnormal_thyroid_gland1.03884730
83MP0004133_heterotaxia1.03673618
84MP0005394_taste/olfaction_phenotype1.02636312
85MP0005499_abnormal_olfactory_system1.02636312
86MP0001929_abnormal_gametogenesis1.02312431
87MP0003806_abnormal_nucleotide_metabolis1.01152488
88MP0002877_abnormal_melanocyte_morpholog1.00587028
89MP0003567_abnormal_fetal_cardiomyocyte1.00545846
90MP0002398_abnormal_bone_marrow0.98499994
91MP0008995_early_reproductive_senescence0.96927979
92MP0004947_skin_inflammation0.96527259
93MP0002796_impaired_skin_barrier0.96487938
94MP0000689_abnormal_spleen_morphology0.95129991
95MP0002722_abnormal_immune_system0.94933361
96MP0000678_abnormal_parathyroid_gland0.94816411
97MP0002132_abnormal_respiratory_system0.94005696
98MP0003329_amyloid_beta_deposits0.93865556
99MP0003705_abnormal_hypodermis_morpholog0.93562065
100MP0008569_lethality_at_weaning0.93461137
101MP0000653_abnormal_sex_gland0.93263475
102MP0000358_abnormal_cell_content/0.93235428
103MP0001873_stomach_inflammation0.93099301
104MP0005501_abnormal_skin_physiology0.90514703
105MP0003091_abnormal_cell_migration0.90492274
106MP0003942_abnormal_urinary_system0.89865339
107MP0001346_abnormal_lacrimal_gland0.88657319
108MP0000049_abnormal_middle_ear0.88608283
109MP0004264_abnormal_extraembryonic_tissu0.88289273
110MP0000858_altered_metastatic_potential0.86501800
111MP0009931_abnormal_skin_appearance0.85981942
112MP0002092_abnormal_eye_morphology0.85392311
113MP0003315_abnormal_perineum_morphology0.84856146
114MP0002111_abnormal_tail_morphology0.83215215
115MP0009672_abnormal_birth_weight0.82881996
116MP0001835_abnormal_antigen_presentation0.82423464
117MP0001119_abnormal_female_reproductive0.80815611
118MP0000477_abnormal_intestine_morphology0.78616112
119MP0003937_abnormal_limbs/digits/tail_de0.78601331
120MP0000428_abnormal_craniofacial_morphol0.77249623
121MP0005384_cellular_phenotype0.76845653
122MP0000685_abnormal_immune_system0.76582012
123MP0002429_abnormal_blood_cell0.76465137
124MP0003634_abnormal_glial_cell0.75691055
125MP0003938_abnormal_ear_development0.75045674
126MP0008874_decreased_physiological_sensi0.74688071
127MP0003935_abnormal_craniofacial_develop0.74583566
128MP0009840_abnormal_foam_cell0.74305426
129MP0000537_abnormal_urethra_morphology0.74032442
130MP0005023_abnormal_wound_healing0.73954513
131MP0010630_abnormal_cardiac_muscle0.73742795
132MP0005621_abnormal_cell_physiology0.72475893
133MP0005310_abnormal_salivary_gland0.71733896
134MP0003115_abnormal_respiratory_system0.71420708
135MP0009053_abnormal_anal_canal0.71319956
136MP0002102_abnormal_ear_morphology0.71012930
137MP0005387_immune_system_phenotype0.70754037
138MP0001790_abnormal_immune_system0.70754037
139MP0003221_abnormal_cardiomyocyte_apopto0.70705923
140MP0005075_abnormal_melanosome_morpholog0.70664838
141MP0002998_abnormal_bone_remodeling0.69942162
142MP0002932_abnormal_joint_morphology0.69825730
143MP0001915_intracranial_hemorrhage0.69676044
144MP0005451_abnormal_body_composition0.69507137
145MP0003646_muscle_fatigue0.69232007
146MP0004185_abnormal_adipocyte_glucose0.68989354
147MP0004087_abnormal_muscle_fiber0.68275727
148MP0005025_abnormal_response_to0.67423145
149MP0001286_abnormal_eye_development0.66947671
150MP0001340_abnormal_eyelid_morphology0.66925162
151MP0003879_abnormal_hair_cell0.66921898
152MP0003279_aneurysm0.66775718
153MP0002116_abnormal_craniofacial_bone0.66341224
154MP0005083_abnormal_biliary_tract0.65487182
155MP0005623_abnormal_meninges_morphology0.64862024
156MP0003699_abnormal_female_reproductive0.63887499
157MP0003075_altered_response_to0.63885010
158MP0000733_abnormal_muscle_development0.63798478
159MP0002405_respiratory_system_inflammati0.62742288
160MP0002127_abnormal_cardiovascular_syste0.62178273
161MP0003861_abnormal_nervous_system0.62017280
162MP0002925_abnormal_cardiovascular_devel0.61787420
163MP0005000_abnormal_immune_tolerance0.61527772
164MP0002148_abnormal_hypersensitivity_rea0.60740360
165MP0002113_abnormal_skeleton_development0.59562299
166MP0001944_abnormal_pancreas_morphology0.57399947

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.28568265
2Breast hypoplasia (HP:0003187)4.08515537
3Ependymoma (HP:0002888)4.05982984
4Obstructive sleep apnea (HP:0002870)3.99531065
5Hyperacusis (HP:0010780)3.69922452
6Oral leukoplakia (HP:0002745)3.52507226
7Patellar aplasia (HP:0006443)3.43051425
8Reticulocytopenia (HP:0001896)3.29429833
9Degeneration of anterior horn cells (HP:0002398)3.27609562
10Abnormality of the anterior horn cell (HP:0006802)3.27609562
11Medulloblastoma (HP:0002885)3.22114434
12Aplasia/Hypoplasia of the patella (HP:0006498)3.19270912
13Selective tooth agenesis (HP:0001592)3.12440293
14Broad face (HP:0000283)3.09156558
15Turricephaly (HP:0000262)3.05564339
16Colon cancer (HP:0003003)3.04707660
17Rib fusion (HP:0000902)3.04622923
18Impulsivity (HP:0100710)3.03653747
19Carpal bone hypoplasia (HP:0001498)3.02023678
20Annular pancreas (HP:0001734)3.01717286
21Chromsome breakage (HP:0040012)2.99589874
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98875140
23Myopathic facies (HP:0002058)2.89234492
24Microretrognathia (HP:0000308)2.85968143
25Cerebral hypomyelination (HP:0006808)2.85879272
26Rough bone trabeculation (HP:0100670)2.85834283
27Aplastic anemia (HP:0001915)2.83384443
28Astrocytoma (HP:0009592)2.75879123
29Abnormality of the astrocytes (HP:0100707)2.75879123
30Abnormality of cells of the erythroid lineage (HP:0012130)2.75605312
31Rhabdomyosarcoma (HP:0002859)2.74019279
32Abnormal number of erythroid precursors (HP:0012131)2.70299982
33Trismus (HP:0000211)2.67013175
34Neoplasm of striated muscle (HP:0009728)2.66610391
35Ulnar bowing (HP:0003031)2.63096373
36Multiple enchondromatosis (HP:0005701)2.62934418
37Achilles tendon contracture (HP:0001771)2.60166078
38Facial hemangioma (HP:0000329)2.57179888
39Long palpebral fissure (HP:0000637)2.57054738
40Hypercortisolism (HP:0001578)2.53860579
41Absent radius (HP:0003974)2.52338861
42Premature ovarian failure (HP:0008209)2.51852955
43Neoplasm of the oral cavity (HP:0100649)2.50400421
44Hyperparathyroidism (HP:0000843)2.50191803
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.49590718
46Meckel diverticulum (HP:0002245)2.46948617
47Absent thumb (HP:0009777)2.45683743
48Broad distal phalanx of finger (HP:0009836)2.44746417
49Abnormality of the ileum (HP:0001549)2.44153842
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.42744378
51Neoplasm of the pancreas (HP:0002894)2.39069465
52Abnormality of the preputium (HP:0100587)2.38848386
53Absent forearm bone (HP:0003953)2.34507676
54Aplasia involving forearm bones (HP:0009822)2.34507676
55Progressive muscle weakness (HP:0003323)2.34024248
56Stridor (HP:0010307)2.32362417
57Myelodysplasia (HP:0002863)2.31014150
58High anterior hairline (HP:0009890)2.30853102
59Glioma (HP:0009733)2.30783255
60Truncus arteriosus (HP:0001660)2.30725759
61Overlapping toe (HP:0001845)2.28273501
62Abnormality of the thoracic spine (HP:0100711)2.27591792
63Supernumerary spleens (HP:0009799)2.26859103
64Shawl scrotum (HP:0000049)2.26436038
65Atrophy/Degeneration involving motor neurons (HP:0007373)2.26177311
66Agnosia (HP:0010524)2.25707120
67Abnormality of chromosome stability (HP:0003220)2.24625124
68Atresia of the external auditory canal (HP:0000413)2.24241422
69Insomnia (HP:0100785)2.21240229
70Abnormality of the Achilles tendon (HP:0005109)2.20774278
71Abnormality of the labia minora (HP:0012880)2.20217902
72Mitral regurgitation (HP:0001653)2.20014465
73Urethral obstruction (HP:0000796)2.19567119
74Gastrointestinal dysmotility (HP:0002579)2.18404428
75Aplasia/hypoplasia of the humerus (HP:0006507)2.18148508
76Duodenal stenosis (HP:0100867)2.17417590
77Small intestinal stenosis (HP:0012848)2.17417590
78Supranuclear gaze palsy (HP:0000605)2.16779779
79Pendular nystagmus (HP:0012043)2.16467344
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16137107
81Basal cell carcinoma (HP:0002671)2.15197410
82Proximal placement of thumb (HP:0009623)2.14672620
83Tracheoesophageal fistula (HP:0002575)2.14353628
84Multiple lipomas (HP:0001012)2.14190467
85Bowel incontinence (HP:0002607)2.12983657
86Distal lower limb muscle weakness (HP:0009053)2.11586811
87Abnormal number of incisors (HP:0011064)2.11530335
88Easy fatigability (HP:0003388)2.10908352
89Thin bony cortex (HP:0002753)2.10858812
90Neuronal loss in central nervous system (HP:0002529)2.10822532
91Difficulty climbing stairs (HP:0003551)2.10326777
92Cerebral aneurysm (HP:0004944)2.09161874
93Hyperthyroidism (HP:0000836)2.09043591
94Bulbar palsy (HP:0001283)2.08916088
95Increased variability in muscle fiber diameter (HP:0003557)2.08908091
96Bone marrow hypocellularity (HP:0005528)2.06984830
97Tongue fasciculations (HP:0001308)2.06050696
98Centrally nucleated skeletal muscle fibers (HP:0003687)2.05307846
99Amaurosis fugax (HP:0100576)2.05256088
100Ectopic kidney (HP:0000086)2.04967769
101Missing ribs (HP:0000921)2.04629273
102Hypertensive crisis (HP:0100735)2.04018353
103Thoracic kyphosis (HP:0002942)2.03672434
104Distal lower limb amyotrophy (HP:0008944)2.03561847
105Upper limb amyotrophy (HP:0009129)2.03376967
106Distal upper limb amyotrophy (HP:0007149)2.03376967
107Horseshoe kidney (HP:0000085)2.00930091
108Premature graying of hair (HP:0002216)2.00155107
109Rectovaginal fistula (HP:0000143)1.99696957
110Rectal fistula (HP:0100590)1.99696957
111Abnormal large intestine physiology (HP:0012700)1.99279552
112Nuclear cataract (HP:0100018)1.99167274
113Increased cerebral lipofuscin (HP:0011813)1.98550779
114Deviation of the thumb (HP:0009603)1.96539089
115Ankle clonus (HP:0011448)1.95642113
116Increased nuchal translucency (HP:0010880)1.94296322
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.92491331
118Abnormal trabecular bone morphology (HP:0100671)1.92014605
119Sloping forehead (HP:0000340)1.91938420
120Reticulocytosis (HP:0001923)1.91175219
121Abnormality of abdominal situs (HP:0011620)1.90960099
122Abdominal situs inversus (HP:0003363)1.90960099
123Segmental peripheral demyelination/remyelination (HP:0003481)1.90754888
124Pointed chin (HP:0000307)1.90569343
125Dysostosis multiplex (HP:0000943)1.90093575
126Increased connective tissue (HP:0009025)1.88612618
127Shallow orbits (HP:0000586)1.88386634
128Muscle fibrillation (HP:0010546)1.88133283
129Intestinal fistula (HP:0100819)1.87228447
130Short humerus (HP:0005792)1.86847891
131Secondary amenorrhea (HP:0000869)1.86476073
132Abnormality of skeletal muscle fiber size (HP:0012084)1.85869680
133Pallor (HP:0000980)1.85838574
134Ragged-red muscle fibers (HP:0003200)1.85428167
135Abnormal lung lobation (HP:0002101)1.85299239
136Prominent nose (HP:0000448)1.85221879
137Abnormality of the duodenum (HP:0002246)1.84934773
138Asymmetry of the thorax (HP:0001555)1.84499420
139Abnormality of the fingertips (HP:0001211)1.83794219
140Visual hallucinations (HP:0002367)1.83204452
141Atelectasis (HP:0100750)1.82512447
142Increased neuronal autofluorescent lipopigment (HP:0002074)1.82368605
143Metaphyseal cupping (HP:0003021)1.81577640
144Abnormality of the carotid arteries (HP:0005344)1.81246667
145Optic nerve coloboma (HP:0000588)1.81160056
146Triphalangeal thumb (HP:0001199)1.80675012
147Cerebral inclusion bodies (HP:0100314)1.80247901
148Renal duplication (HP:0000075)1.80144875
149Cafe-au-lait spot (HP:0000957)1.79897639
150Protrusio acetabuli (HP:0003179)1.79576704
151Abnormality of the aortic arch (HP:0012303)1.78952480
152Broad alveolar ridges (HP:0000187)1.78379247
153Deep palmar crease (HP:0006191)1.78042361
154Preauricular skin tag (HP:0000384)1.77982268
155Gastrointestinal inflammation (HP:0004386)1.77060199
156Dysmetric saccades (HP:0000641)1.76975902
157Macrocytic anemia (HP:0001972)1.76913005
158Neurofibrillary tangles (HP:0002185)1.75610305
159Bilateral microphthalmos (HP:0007633)1.75463359
160Peripheral hypomyelination (HP:0007182)1.75123876
161Cellular immunodeficiency (HP:0005374)1.74410784
162Slender long bone (HP:0003100)1.73598775
163Vaginal fistula (HP:0004320)1.73402581
164Emphysema (HP:0002097)1.73161519
165Abnormality of the distal phalanx of the thumb (HP:0009617)1.73078311
166Hypercalcemia (HP:0003072)1.69841106
167Overriding aorta (HP:0002623)1.69123825
168Axonal loss (HP:0003447)1.68785550
169Flattened epiphyses (HP:0003071)1.68666152
170Hemorrhage of the eye (HP:0011885)1.68149820
171Vertebral compression fractures (HP:0002953)1.67990276
172Genu recurvatum (HP:0002816)1.67278330
173Exercise-induced myalgia (HP:0003738)1.66952804
174Polygenic inheritance (HP:0010982)1.65878434
175Deep venous thrombosis (HP:0002625)1.65450453
176Mildly elevated creatine phosphokinase (HP:0008180)1.65139835
177Patellar dislocation (HP:0002999)1.64378688
178Bronchomalacia (HP:0002780)1.63784866
179Bowing of the arm (HP:0006488)1.62988079
180Bowed forearm bones (HP:0003956)1.62988079
181Germ cell neoplasia (HP:0100728)1.62406434
182Neonatal hypoglycemia (HP:0001998)1.60761861
183Slow saccadic eye movements (HP:0000514)1.60295636
184Disproportionate tall stature (HP:0001519)1.60286730
185Macroorchidism (HP:0000053)1.59120528
186Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58412455
187Asymmetric septal hypertrophy (HP:0001670)1.58224863
188Blue sclerae (HP:0000592)1.57424867
189Abnormality of the columella (HP:0009929)1.56888847
190Broad metatarsal (HP:0001783)1.56778405
191Lower limb asymmetry (HP:0100559)1.55493732
192Prolonged neonatal jaundice (HP:0006579)1.55424887
193Spinal cord compression (HP:0002176)1.55269465
194Squamous cell carcinoma (HP:0002860)1.54558146
195Cellulitis (HP:0100658)1.54468115
196Flat acetabular roof (HP:0003180)1.53908369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.96873448
2PRPF4B3.82256340
3SMG13.75176283
4SIK13.61421902
5EEF2K3.43044226
6CDK123.25233466
7CDC73.10573625
8WEE13.01006664
9NEK23.00325940
10MAP3K102.53563414
11ACVR1B2.48574668
12IRAK32.41862710
13TTK2.41057383
14EIF2AK12.26358707
15DYRK32.24697795
16TESK22.04238386
17PRKD32.03360840
18CDK72.02450864
19MAPKAPK32.02252880
20RPS6KB21.99870674
21RPS6KA41.90467870
22PLK11.79339358
23SRPK11.76075632
24PRKD21.72971507
25NEK11.70825302
26NME21.56674871
27EPHA21.51820430
28RIPK11.50474650
29STK101.49155835
30CDK41.48388540
31ATR1.45905026
32CHEK21.43768066
33AURKB1.41234020
34PLK41.36657365
35MAP4K11.35041952
36BMX1.33691806
37ERN11.32822820
38PTK61.31880403
39IRAK21.30393283
40MAP3K81.28509820
41SIK21.27338186
42MARK21.26521556
43TTN1.24145834
44TLK11.22458737
45VRK11.21481174
46LATS21.19999534
47TBK11.18473507
48BRSK21.14035928
49PASK1.13905641
50PAK41.13772367
51RIPK41.11783633
52STK161.11774451
53AURKA1.11382989
54TSSK61.11234597
55CHEK11.10308041
56FLT31.08695758
57BCKDK1.07090652
58CDC42BPA1.06531779
59FGFR41.06294683
60DDR21.03034747
61PKN21.00296173
62PDGFRA0.99764042
63TRIB30.99512606
64CAMK1D0.98740706
65GRK60.97345694
66IRAK40.96505974
67MAP3K30.94919632
68RPS6KC10.93714512
69RPS6KL10.93714512
70BRD40.93173055
71CAMKK10.92731797
72MAP3K10.91752076
73MAP3K110.90875224
74TGFBR10.90338880
75PDPK10.88310635
76ICK0.88284358
77MKNK10.85807072
78BRSK10.85570800
79RPS6KA20.85461570
80DYRK20.84540996
81STK40.84167098
82MAP3K90.84162568
83TNK20.83840508
84CDK20.83550443
85PRKCH0.83459355
86MTOR0.81493124
87CDK80.79262317
88CCNB10.77640315
89PIM10.76844183
90SCYL20.76426928
91MAP3K130.76162855
92KDR0.75716440
93RPS6KA60.75523410
94CSF1R0.73936023
95ATM0.71893521
96EIF2AK30.71693582
97VRK20.68479845
98MAPK110.68325802
99MELK0.68125799
100MAP3K60.64423341
101UHMK10.63853851
102PAK10.63469187
103AKT20.63060040
104MAPK120.62062035
105ALK0.61958881
106KSR20.60264886
107LATS10.60074208
108STK30.58483115
109MAP3K70.58158366
110PLK30.57022859
111STK38L0.56278327
112PRKG20.56271136
113PRKCI0.53637773
114TAOK10.52560379
115TYRO30.51504558
116BTK0.50464130
117MATK0.49947462
118CSK0.49720177
119CDK190.49580415
120ZAP700.49431274
121CDK10.48857418
122CDK60.48801779
123MAPK150.47934724
124PDK10.47733390
125MST1R0.46914616
126TYK20.46678199
127NME10.46168938
128DYRK1B0.45003934
129TAOK20.44711482
130MKNK20.44663621
131MAP2K20.44660664
132CAMK1G0.44653602
133BRAF0.44375760
134PIM20.43694272
135PTK20.43444941
136EPHB10.42085842
137TESK10.41425310
138WNK30.41351023
139MAPK40.41273297
140RAF10.41139266
141CSNK2A20.40565695
142BLK0.40002728
143RPS6KA50.39653256
144HIPK20.39563867
145LRRK20.39426937
146NLK0.39283647
147CSNK2A10.39275052
148ARAF0.39191251
149MAP2K30.39167934
150RPS6KA10.39046673
151CDK90.39026079
152NTRK10.38715811
153PAK60.37605666
154IKBKB0.37000999
155KSR10.35287421
156DAPK30.32762480
157CHUK0.32116963
158STK380.31882715
159SGK30.31857101
160EPHB20.30893147
161CDK11A0.30780370
162MAP2K60.30020185
163MAPKAPK20.27194110

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72950390
2Mismatch repair_Homo sapiens_hsa034303.88739959
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43556971
4Spliceosome_Homo sapiens_hsa030403.16373880
5Base excision repair_Homo sapiens_hsa034103.15063451
6RNA transport_Homo sapiens_hsa030133.05105117
7RNA polymerase_Homo sapiens_hsa030202.99060370
8Cell cycle_Homo sapiens_hsa041102.87264760
9Ribosome_Homo sapiens_hsa030102.73083497
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.67685542
11Homologous recombination_Homo sapiens_hsa034402.61093594
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.45786410
13Nucleotide excision repair_Homo sapiens_hsa034202.39659212
14One carbon pool by folate_Homo sapiens_hsa006702.38575913
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26727070
16Pyrimidine metabolism_Homo sapiens_hsa002402.18171616
17RNA degradation_Homo sapiens_hsa030181.89664754
18Fanconi anemia pathway_Homo sapiens_hsa034601.86443956
19Basal transcription factors_Homo sapiens_hsa030221.86037112
20mRNA surveillance pathway_Homo sapiens_hsa030151.81799903
21Proteasome_Homo sapiens_hsa030501.80912815
22Prion diseases_Homo sapiens_hsa050201.78765855
23p53 signaling pathway_Homo sapiens_hsa041151.66785490
24Vitamin B6 metabolism_Homo sapiens_hsa007501.55731810
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.53653310
26Non-homologous end-joining_Homo sapiens_hsa034501.53616308
27Renal cell carcinoma_Homo sapiens_hsa052111.44510760
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38255611
29Folate biosynthesis_Homo sapiens_hsa007901.37164750
30Insulin signaling pathway_Homo sapiens_hsa049101.32387051
31Glioma_Homo sapiens_hsa052141.30683868
32Sulfur relay system_Homo sapiens_hsa041221.26675074
33Prolactin signaling pathway_Homo sapiens_hsa049171.22647613
34ErbB signaling pathway_Homo sapiens_hsa040121.19631473
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19327326
36Estrogen signaling pathway_Homo sapiens_hsa049151.17367429
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15831668
38GnRH signaling pathway_Homo sapiens_hsa049121.15083873
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.15045028
40Selenocompound metabolism_Homo sapiens_hsa004501.15023300
41Herpes simplex infection_Homo sapiens_hsa051681.13525962
42TNF signaling pathway_Homo sapiens_hsa046681.12662463
43Osteoclast differentiation_Homo sapiens_hsa043801.09431383
44Biosynthesis of amino acids_Homo sapiens_hsa012301.08467408
45Long-term potentiation_Homo sapiens_hsa047201.08369269
46Epstein-Barr virus infection_Homo sapiens_hsa051691.08062588
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.06902178
48Purine metabolism_Homo sapiens_hsa002301.04581716
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03034491
50AMPK signaling pathway_Homo sapiens_hsa041521.02155056
51Pentose phosphate pathway_Homo sapiens_hsa000301.01447934
52Notch signaling pathway_Homo sapiens_hsa043301.00512064
53T cell receptor signaling pathway_Homo sapiens_hsa046601.00019219
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98329370
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97443942
56Hepatitis C_Homo sapiens_hsa051600.95694509
57Prostate cancer_Homo sapiens_hsa052150.95143481
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93460575
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93412862
60MAPK signaling pathway_Homo sapiens_hsa040100.93064546
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91827835
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.91817698
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91289437
64Insulin resistance_Homo sapiens_hsa049310.91038927
65Thyroid cancer_Homo sapiens_hsa052160.90303634
66Leishmaniasis_Homo sapiens_hsa051400.90162327
67Viral carcinogenesis_Homo sapiens_hsa052030.88460557
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87897001
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86911712
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.86683879
71HTLV-I infection_Homo sapiens_hsa051660.84333780
72Cocaine addiction_Homo sapiens_hsa050300.83204012
73Lysosome_Homo sapiens_hsa041420.81858098
74Type II diabetes mellitus_Homo sapiens_hsa049300.80081369
75Systemic lupus erythematosus_Homo sapiens_hsa053220.78988049
76Colorectal cancer_Homo sapiens_hsa052100.78313430
77Basal cell carcinoma_Homo sapiens_hsa052170.77076851
78Melanogenesis_Homo sapiens_hsa049160.76833581
79MicroRNAs in cancer_Homo sapiens_hsa052060.76693708
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.73409623
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73259325
82Antigen processing and presentation_Homo sapiens_hsa046120.72131356
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72092163
84Oocyte meiosis_Homo sapiens_hsa041140.71477716
85Acute myeloid leukemia_Homo sapiens_hsa052210.69938826
86Small cell lung cancer_Homo sapiens_hsa052220.69731622
87Toxoplasmosis_Homo sapiens_hsa051450.68590110
88Hippo signaling pathway_Homo sapiens_hsa043900.68026287
89Choline metabolism in cancer_Homo sapiens_hsa052310.66935053
90Bladder cancer_Homo sapiens_hsa052190.66872599
91Synaptic vesicle cycle_Homo sapiens_hsa047210.66640960
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66051912
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65137495
94Endocytosis_Homo sapiens_hsa041440.65105273
95Primary immunodeficiency_Homo sapiens_hsa053400.64154222
96mTOR signaling pathway_Homo sapiens_hsa041500.62882654
97Tuberculosis_Homo sapiens_hsa051520.62634116
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62470851
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.62463616
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60467377
101Chronic myeloid leukemia_Homo sapiens_hsa052200.60466734
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60384384
103Fructose and mannose metabolism_Homo sapiens_hsa000510.59407084
104Apoptosis_Homo sapiens_hsa042100.58787361
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58167043
106Inositol phosphate metabolism_Homo sapiens_hsa005620.57913816
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56514930
108FoxO signaling pathway_Homo sapiens_hsa040680.56121494
109Cholinergic synapse_Homo sapiens_hsa047250.53809152
110Chemokine signaling pathway_Homo sapiens_hsa040620.53143442
111Glucagon signaling pathway_Homo sapiens_hsa049220.53024402
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52651792
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51791711
114Carbon metabolism_Homo sapiens_hsa012000.51657834
115Proteoglycans in cancer_Homo sapiens_hsa052050.51479759
116TGF-beta signaling pathway_Homo sapiens_hsa043500.51476417
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.50859604
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50329046
119Gap junction_Homo sapiens_hsa045400.49646806
120Legionellosis_Homo sapiens_hsa051340.49524264
121Amoebiasis_Homo sapiens_hsa051460.48534983
122Rap1 signaling pathway_Homo sapiens_hsa040150.47687102
123Hepatitis B_Homo sapiens_hsa051610.47514080
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47498663
125Galactose metabolism_Homo sapiens_hsa000520.47266910
126Shigellosis_Homo sapiens_hsa051310.45932953
127N-Glycan biosynthesis_Homo sapiens_hsa005100.44930368
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44367543
129Adherens junction_Homo sapiens_hsa045200.39504094
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.39381353
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37219878
132Measles_Homo sapiens_hsa051620.35969147
133Pancreatic cancer_Homo sapiens_hsa052120.34807639
134Pathways in cancer_Homo sapiens_hsa052000.34680239
135Linoleic acid metabolism_Homo sapiens_hsa005910.34388396
136Lysine degradation_Homo sapiens_hsa003100.33984938
137Non-small cell lung cancer_Homo sapiens_hsa052230.33849625
138Hedgehog signaling pathway_Homo sapiens_hsa043400.33666770
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32633549
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31035883
141Other glycan degradation_Homo sapiens_hsa005110.30151582
142Influenza A_Homo sapiens_hsa051640.30132979
143Endometrial cancer_Homo sapiens_hsa052130.29821101
144Glutathione metabolism_Homo sapiens_hsa004800.29571297
145B cell receptor signaling pathway_Homo sapiens_hsa046620.27859643
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26398445
147VEGF signaling pathway_Homo sapiens_hsa043700.25812447
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.24804808
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24236377
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24071639
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22452013
152Viral myocarditis_Homo sapiens_hsa054160.21791682
153Arginine and proline metabolism_Homo sapiens_hsa003300.21519767
154HIF-1 signaling pathway_Homo sapiens_hsa040660.21155956
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.20937058
156Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20901712

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