FJX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact function of this gene in humans is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.49835792
2layer formation in cerebral cortex (GO:0021819)5.25236584
3vocalization behavior (GO:0071625)5.11125337
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.09580345
5neuron cell-cell adhesion (GO:0007158)4.97742200
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.97364156
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.84914148
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.71350367
9synaptic vesicle maturation (GO:0016188)4.54309796
10glutamate secretion (GO:0014047)4.51534872
11protein localization to synapse (GO:0035418)4.49797108
12regulation of glutamate receptor signaling pathway (GO:1900449)4.45656077
13neuron projection extension involved in neuron projection guidance (GO:1902284)4.44471746
14axon extension involved in axon guidance (GO:0048846)4.44471746
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37959081
16exploration behavior (GO:0035640)4.32148105
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.31631524
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.29512466
19dendritic spine morphogenesis (GO:0060997)4.28601745
20synaptic vesicle exocytosis (GO:0016079)4.27442855
21neurotransmitter-gated ion channel clustering (GO:0072578)4.25298856
22gamma-aminobutyric acid transport (GO:0015812)4.19311097
23glutamate receptor signaling pathway (GO:0007215)4.10487625
24L-amino acid import (GO:0043092)4.07900996
25axon extension (GO:0048675)4.07382738
26regulation of synapse structural plasticity (GO:0051823)3.97452925
27auditory behavior (GO:0031223)3.95070086
28proline transport (GO:0015824)3.94896421
29cellular potassium ion homeostasis (GO:0030007)3.92559150
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91219762
31postsynaptic membrane organization (GO:0001941)3.90727040
32neuron recognition (GO:0008038)3.89129029
33regulation of neuronal synaptic plasticity (GO:0048168)3.86532863
34amino acid import (GO:0043090)3.78713974
35synaptic transmission, glutamatergic (GO:0035249)3.75993675
36dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.75791811
37axonal fasciculation (GO:0007413)3.74950754
38regulation of synaptic vesicle exocytosis (GO:2000300)3.74172798
39C4-dicarboxylate transport (GO:0015740)3.73265055
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.72079523
41paraxial mesoderm development (GO:0048339)3.69265388
42sodium ion export (GO:0071436)3.67988526
43neurotransmitter secretion (GO:0007269)3.66674764
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.65472763
45response to auditory stimulus (GO:0010996)3.65431110
46dendrite morphogenesis (GO:0048813)3.64660708
47cochlea morphogenesis (GO:0090103)3.60702614
48hemidesmosome assembly (GO:0031581)3.59235834
49neuronal action potential propagation (GO:0019227)3.58327202
50regulation of dendritic spine morphogenesis (GO:0061001)3.58201934
51alanine transport (GO:0032328)3.55941639
52heparan sulfate proteoglycan metabolic process (GO:0030201)3.48939006
53central nervous system projection neuron axonogenesis (GO:0021952)3.48754910
54transmission of nerve impulse (GO:0019226)3.48516500
55innervation (GO:0060384)3.48062886
56regulation of establishment of planar polarity (GO:0090175)3.45899450
57neuron projection extension (GO:1990138)3.43978917
58positive regulation of synapse maturation (GO:0090129)3.41508912
59cell migration in hindbrain (GO:0021535)3.40871015
60neuron-neuron synaptic transmission (GO:0007270)3.40839586
61long-term memory (GO:0007616)3.39864939
62G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.39813394
63proximal/distal pattern formation (GO:0009954)3.39311970
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.38437499
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.37017731
66presynaptic membrane assembly (GO:0097105)3.36454198
67positive regulation of dendritic spine development (GO:0060999)3.36112986
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.35169077
69cell communication by electrical coupling (GO:0010644)3.34711964
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.33493033
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29916765
72negative regulation of axon extension involved in axon guidance (GO:0048843)3.25633467
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25373331
74convergent extension (GO:0060026)3.24127391
75regulation of dendritic spine development (GO:0060998)3.21263337
76neuromuscular process controlling balance (GO:0050885)3.20736541
77negative regulation of astrocyte differentiation (GO:0048712)3.20567608
78regulation of synaptic vesicle transport (GO:1902803)3.19160011
79regulation of axon extension involved in axon guidance (GO:0048841)3.17914670
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.17234656
81regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16934512
82ganglion development (GO:0061548)3.16742180
83regulation of synaptic plasticity (GO:0048167)3.15794950
84lens fiber cell development (GO:0070307)3.14597842
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12906420
86negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12539337
87cerebellar granule cell differentiation (GO:0021707)3.12334039
88synapse assembly (GO:0007416)3.11355855
89long-term synaptic potentiation (GO:0060291)3.11102338
90chondrocyte proliferation (GO:0035988)3.08476134
91positive regulation of membrane potential (GO:0045838)3.07991897
92negative regulation of axon guidance (GO:1902668)3.07138671
93regulation of postsynaptic membrane potential (GO:0060078)3.06984253
94regulation of axon guidance (GO:1902667)3.06855543
95positive regulation of synapse assembly (GO:0051965)3.05838303
96heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.05166221
97mechanosensory behavior (GO:0007638)3.05064395
98mating behavior (GO:0007617)3.02287932
99presynaptic membrane organization (GO:0097090)3.01650999
100regulation of hair follicle development (GO:0051797)3.00567370
101neurotransmitter transport (GO:0006836)2.99120626
102gamma-aminobutyric acid signaling pathway (GO:0007214)2.98899364
103neuronal stem cell maintenance (GO:0097150)2.98579587
104non-canonical Wnt signaling pathway (GO:0035567)2.98414811
105positive regulation of hair follicle development (GO:0051798)2.98004877
106positive regulation of hair cycle (GO:0042635)2.98004877
107cerebral cortex neuron differentiation (GO:0021895)2.97823290
108cerebral cortex radially oriented cell migration (GO:0021799)2.97448704
109camera-type eye morphogenesis (GO:0048593)2.97027430
110response to histamine (GO:0034776)2.94368417
111synapse organization (GO:0050808)2.91854252
112anatomical structure regression (GO:0060033)2.90837445
113cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90812515
114establishment of tissue polarity (GO:0007164)2.90169657
115establishment of planar polarity (GO:0001736)2.90169657
116outer ear morphogenesis (GO:0042473)2.88130090
117dendritic spine organization (GO:0097061)2.88079023
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.87591296
119prepulse inhibition (GO:0060134)2.87078679
120pyrimidine nucleobase catabolic process (GO:0006208)2.85434209
121negative regulation of chondrocyte differentiation (GO:0032331)2.85084403
122regulation of neurotransmitter levels (GO:0001505)2.84657530
123glial cell proliferation (GO:0014009)2.83136033
124branching involved in salivary gland morphogenesis (GO:0060445)2.82693238
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.82389975
126lateral sprouting from an epithelium (GO:0060601)2.82078409
127neuronal ion channel clustering (GO:0045161)2.81624730
128activation of protein kinase A activity (GO:0034199)2.81158860
129positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80668839
130negative regulation of catenin import into nucleus (GO:0035414)2.80510180
131axon ensheathment in central nervous system (GO:0032291)2.79829451
132central nervous system myelination (GO:0022010)2.79829451
133regulation of vesicle fusion (GO:0031338)2.79534331
134pattern specification involved in kidney development (GO:0061004)2.78976115
135central nervous system neuron axonogenesis (GO:0021955)2.75343181
136learning (GO:0007612)2.75127667
137regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74992298
138negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.74024589
139behavioral defense response (GO:0002209)2.74007337
140behavioral fear response (GO:0001662)2.74007337
141Notch signaling involved in heart development (GO:0061314)2.73062858
142notochord development (GO:0030903)2.72671698
143kidney mesenchyme development (GO:0072074)2.72628418
144positive regulation of smoothened signaling pathway (GO:0045880)2.72353398
145cell adhesion mediated by integrin (GO:0033627)2.70805699
146regulation of respiratory system process (GO:0044065)2.70786529
147positive regulation of osteoblast proliferation (GO:0033690)2.69257577
148negative regulation of sodium ion transport (GO:0010766)2.68570682
149dermatan sulfate biosynthetic process (GO:0030208)2.68258496
150glial cell migration (GO:0008347)2.67238688
151spinal cord development (GO:0021510)2.63945470
152semaphorin-plexin signaling pathway (GO:0071526)2.63910528
153regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63121840
154developmental cell growth (GO:0048588)2.57173378
155proteoglycan metabolic process (GO:0006029)2.55374559
156cardiovascular system development (GO:0072358)2.53168127
157retinal ganglion cell axon guidance (GO:0031290)2.52686839
158developmental growth involved in morphogenesis (GO:0060560)2.52553273
159positive regulation of neuroblast proliferation (GO:0002052)2.52275529
160substrate-dependent cell migration (GO:0006929)2.51813149
161digestive tract morphogenesis (GO:0048546)2.50836208
162cellular response to vitamin D (GO:0071305)2.50455199
163endodermal cell differentiation (GO:0035987)2.50423044
164cell migration involved in sprouting angiogenesis (GO:0002042)2.49133104
165dermatan sulfate metabolic process (GO:0030205)2.49051030
166neuroblast proliferation (GO:0007405)2.48793387
167lens morphogenesis in camera-type eye (GO:0002089)2.48518126
168cranial nerve morphogenesis (GO:0021602)2.47343768
169regulation of NFAT protein import into nucleus (GO:0051532)2.46120273
170forebrain neuron differentiation (GO:0021879)2.45958377
171negative chemotaxis (GO:0050919)2.45433866
172substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.44930096
173substrate-independent telencephalic tangential migration (GO:0021826)2.44930096
174skin morphogenesis (GO:0043589)2.43194810
175positive regulation of axon extension (GO:0045773)2.42363362
176morphogenesis of an epithelial sheet (GO:0002011)2.40934151
177hippo signaling (GO:0035329)2.40300234
178mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.39391635
179establishment of monopolar cell polarity (GO:0061162)2.38869647
180establishment or maintenance of monopolar cell polarity (GO:0061339)2.38869647
181neural crest cell development (GO:0014032)2.37533165
182epithelial tube branching involved in lung morphogenesis (GO:0060441)2.37479256
183bone trabecula formation (GO:0060346)2.37095087
184mesenchymal-epithelial cell signaling (GO:0060638)2.35403387
185apical protein localization (GO:0045176)2.33510673
186heterochromatin organization (GO:0070828)2.32656096
187calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.32246614
188mesenchyme morphogenesis (GO:0072132)2.32007085
189cell proliferation in forebrain (GO:0021846)2.31775919
190mitotic cytokinesis (GO:0000281)2.31377741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.64256723
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.60053011
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.29691556
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.23123792
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17412777
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.01813664
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.94948285
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.94948285
9GBX2_23144817_ChIP-Seq_PC3_Human2.93797000
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.89227467
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.88432310
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.84200692
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.75762009
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73710184
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.71828375
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58339973
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.48979360
18AR_21572438_ChIP-Seq_LNCaP_Human2.48211507
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44489086
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37887639
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.36499998
22REST_21632747_ChIP-Seq_MESCs_Mouse2.35790371
23DROSHA_22980978_ChIP-Seq_HELA_Human2.20608081
24* RARB_27405468_Chip-Seq_BRAIN_Mouse2.12745058
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01125141
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92604177
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91261288
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84638705
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.84289397
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.81295489
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80303965
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80143591
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79054809
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77879778
35* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77010029
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74229742
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71004520
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70864496
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.70686783
40* RING1B_27294783_Chip-Seq_ESCs_Mouse1.68081270
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.67593000
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67016378
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56079281
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54817214
45* RING1B_27294783_Chip-Seq_NPCs_Mouse1.50186430
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49509432
47* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49434813
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.49016426
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44975112
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43391740
51* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41830715
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39599873
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36494951
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.34771453
55* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34687833
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.33991377
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.32322663
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31786736
59ZNF274_21170338_ChIP-Seq_K562_Hela1.30261518
60SMAD4_21799915_ChIP-Seq_A2780_Human1.28872267
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28389616
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27790855
63* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27573794
64TP53_22127205_ChIP-Seq_IMR90_Human1.26500969
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.26185823
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24517264
67* UBF1/2_26484160_Chip-Seq_HMECs_Human1.23955127
68P300_19829295_ChIP-Seq_ESCs_Human1.23300210
69* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22047455
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.20215562
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19793032
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.19659522
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.18925484
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18133586
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.18109728
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17389206
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.17284870
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17280739
79* AR_19668381_ChIP-Seq_PC3_Human1.16601231
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16471018
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14754939
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13972610
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13870881
84AR_25329375_ChIP-Seq_VCAP_Human1.13866243
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13026686
86TP53_16413492_ChIP-PET_HCT116_Human1.12630589
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12376041
88* KDM2B_26808549_Chip-Seq_K562_Human1.12194376
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12034163
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.11298883
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11230625
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11171562
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10595644
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09352121
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.09307701
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08793374
97ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08255398
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07812303
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07679109
100TAF15_26573619_Chip-Seq_HEK293_Human1.06851981
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05905412
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05657579
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05321993
104TRIM28_21343339_ChIP-Seq_HEK293_Human1.04758120
105RNF2_27304074_Chip-Seq_NSC_Mouse1.04702658
106CLOCK_20551151_ChIP-Seq_293T_Human1.04508986
107AHR_22903824_ChIP-Seq_MCF-7_Human1.04463289
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04336635
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03842304
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03842304
111* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03595237
112LXR_22292898_ChIP-Seq_THP-1_Human1.03562350
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02889503
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01874443
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01772022
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01647228
117* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01104918
118TP53_23651856_ChIP-Seq_MEFs_Mouse1.00588316
119RXR_22108803_ChIP-Seq_LS180_Human0.99545434
120ZNF263_19887448_ChIP-Seq_K562_Human0.99525334
121TP53_18474530_ChIP-ChIP_U2OS_Human0.99484942
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99244238
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99220814
124GATA1_26923725_Chip-Seq_HPCs_Mouse0.99166598
125* SA1_22415368_ChIP-Seq_MEFs_Mouse0.97190138
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97160405
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.96641311
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.96362411
129FUS_26573619_Chip-Seq_HEK293_Human0.96360730
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96135540
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95975024
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95485982
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.94418027
134SOX3_22085726_ChIP-Seq_NPCs_Mouse0.94195182
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93886007
136CTCF_27219007_Chip-Seq_Bcells_Human0.93705565
137* STAT3_23295773_ChIP-Seq_U87_Human0.93557517
138* RACK7_27058665_Chip-Seq_MCF-7_Human0.93177127
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.93058257
140POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92773994
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92317269
142* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91948849
143TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90648952
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90619751
145* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89519268
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89381048
147SOX2_16153702_ChIP-ChIP_HESCs_Human0.88564572
148STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88084842
149BCAT_22108803_ChIP-Seq_LS180_Human0.87847655
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87601604
151NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87383650
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86255079
153DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86148562
154KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85802029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.65862619
2MP0003880_abnormal_central_pattern3.98298576
3MP0003635_abnormal_synaptic_transmissio3.72309636
4MP0004270_analgesia3.29884283
5MP0003705_abnormal_hypodermis_morpholog3.28386664
6MP0002063_abnormal_learning/memory/cond3.04800350
7MP0009745_abnormal_behavioral_response2.97034667
8MP0002877_abnormal_melanocyte_morpholog2.92047025
9MP0005423_abnormal_somatic_nervous2.80390370
10MP0009053_abnormal_anal_canal2.73927420
11MP0002064_seizures2.70286712
12MP0001486_abnormal_startle_reflex2.69686041
13MP0004858_abnormal_nervous_system2.69481553
14MP0005257_abnormal_intraocular_pressure2.57721321
15MP0000778_abnormal_nervous_system2.56679294
16MP0002572_abnormal_emotion/affect_behav2.54481227
17MP0009046_muscle_twitch2.48713038
18MP0000579_abnormal_nail_morphology2.46224316
19MP0001968_abnormal_touch/_nociception2.35808910
20MP0009780_abnormal_chondrocyte_physiolo2.30439919
21MP0002734_abnormal_mechanical_nocicepti2.23361451
22MP0003329_amyloid_beta_deposits2.20321788
23MP0004885_abnormal_endolymph2.13487952
24MP0001440_abnormal_grooming_behavior2.13235594
25MP0001346_abnormal_lacrimal_gland2.07867345
26MP0002272_abnormal_nervous_system2.01595022
27MP0004272_abnormal_basement_membrane1.99622866
28MP0005248_abnormal_Harderian_gland1.97646522
29MP0002733_abnormal_thermal_nociception1.87939218
30MP0002736_abnormal_nociception_after1.86184941
31MP0000462_abnormal_digestive_system1.85276411
32MP0004133_heterotaxia1.84999573
33MP0000762_abnormal_tongue_morphology1.82891913
34MP0001501_abnormal_sleep_pattern1.79578201
35MP0002697_abnormal_eye_size1.77348319
36MP0002557_abnormal_social/conspecific_i1.77098432
37MP0008569_lethality_at_weaning1.76947712
38MP0003315_abnormal_perineum_morphology1.76200648
39MP0002184_abnormal_innervation1.73204197
40MP0000955_abnormal_spinal_cord1.68972875
41MP0002067_abnormal_sensory_capabilities1.68615116
42MP0005623_abnormal_meninges_morphology1.68070269
43MP0001970_abnormal_pain_threshold1.60565426
44MP0001849_ear_inflammation1.55374140
45MP0005646_abnormal_pituitary_gland1.54446943
46MP0002653_abnormal_ependyma_morphology1.53703579
47MP0002735_abnormal_chemical_nociception1.52080530
48MP0000428_abnormal_craniofacial_morphol1.51780036
49MP0009379_abnormal_foot_pigmentation1.50887805
50MP0004811_abnormal_neuron_physiology1.50281392
51MP0008438_abnormal_cutaneous_collagen1.49560214
52MP0002092_abnormal_eye_morphology1.48717070
53MP0009384_cardiac_valve_regurgitation1.46898665
54MP0001502_abnormal_circadian_rhythm1.45221359
55* MP0002882_abnormal_neuron_morphology1.44966902
56MP0002822_catalepsy1.42108008
57MP0005386_behavior/neurological_phenoty1.38958723
58MP0004924_abnormal_behavior1.38958723
59MP0003937_abnormal_limbs/digits/tail_de1.38824477
60MP0002152_abnormal_brain_morphology1.38512755
61MP0003690_abnormal_glial_cell1.37311618
62MP0010368_abnormal_lymphatic_system1.36809315
63MP0002233_abnormal_nose_morphology1.33323846
64MP0005197_abnormal_uvea_morphology1.32403531
65MP0001984_abnormal_olfaction1.31113601
66MP0002066_abnormal_motor_capabilities/c1.30525179
67MP0003634_abnormal_glial_cell1.30223265
68MP0002282_abnormal_trachea_morphology1.28344010
69MP0002896_abnormal_bone_mineralization1.27207947
70MP0003279_aneurysm1.26878808
71MP0001293_anophthalmia1.24244891
72MP0003091_abnormal_cell_migration1.22719193
73MP0003633_abnormal_nervous_system1.21930508
74MP0003941_abnormal_skin_development1.17123445
75MP0000631_abnormal_neuroendocrine_gland1.16590820
76MP0002909_abnormal_adrenal_gland1.15716585
77MP0002116_abnormal_craniofacial_bone1.15686151
78MP0005508_abnormal_skeleton_morphology1.12046106
79MP0003938_abnormal_ear_development1.08893443
80MP0003631_nervous_system_phenotype1.08295221
81MP0001905_abnormal_dopamine_level1.08205861
82MP0003283_abnormal_digestive_organ1.08011962
83MP0005394_taste/olfaction_phenotype1.07591935
84MP0005499_abnormal_olfactory_system1.07591935
85MP0000733_abnormal_muscle_development1.07401911
86MP0001958_emphysema1.07245859
87MP0002249_abnormal_larynx_morphology1.06796971
88MP0001286_abnormal_eye_development1.06006973
89MP0003861_abnormal_nervous_system1.04970192
90MP0006276_abnormal_autonomic_nervous1.04892956
91MP0000049_abnormal_middle_ear1.04748102
92MP0004742_abnormal_vestibular_system1.04744256
93MP0001879_abnormal_lymphatic_vessel1.04586434
94MP0004142_abnormal_muscle_tone1.03508226
95MP0003119_abnormal_digestive_system1.02361387
96MP0005076_abnormal_cell_differentiation1.02133053
97MP0000432_abnormal_head_morphology1.01647405
98MP0008932_abnormal_embryonic_tissue0.99893536
99MP0002111_abnormal_tail_morphology0.99623355
100MP0001529_abnormal_vocalization0.99347401
101MP0001485_abnormal_pinna_reflex0.98536726
102MP0001188_hyperpigmentation0.98262893
103MP0001299_abnormal_eye_distance/0.97666288
104MP0004233_abnormal_muscle_weight0.96977049
105MP0003935_abnormal_craniofacial_develop0.96843374
106MP0002081_perinatal_lethality0.96114525
107MP0003632_abnormal_nervous_system0.95561640
108MP0005084_abnormal_gallbladder_morpholo0.94001386
109MP0000647_abnormal_sebaceous_gland0.93812946
110MP0001177_atelectasis0.93460685
111MP0001340_abnormal_eyelid_morphology0.92004531
112MP0006292_abnormal_olfactory_placode0.91956900
113MP0002752_abnormal_somatic_nervous0.90551401
114MP0003136_yellow_coat_color0.90351068
115MP0003453_abnormal_keratinocyte_physiol0.89679304
116MP0001963_abnormal_hearing_physiology0.88436687
117MP0000534_abnormal_ureter_morphology0.88253568
118MP0003122_maternal_imprinting0.87383074
119MP0003566_abnormal_cell_adhesion0.86535385
120MP0001542_abnormal_bone_strength0.85915629
121MP0001348_abnormal_lacrimal_gland0.85888434
122MP0003075_altered_response_to0.85366367
123MP0005645_abnormal_hypothalamus_physiol0.85203863
124MP0002098_abnormal_vibrissa_morphology0.84863741
125MP0000026_abnormal_inner_ear0.84734830
126MP0003879_abnormal_hair_cell0.84580047
127MP0000767_abnormal_smooth_muscle0.84422764
128MP0000467_abnormal_esophagus_morphology0.83329803
129MP0005023_abnormal_wound_healing0.82895656
130MP0000604_amyloidosis0.82649816
131MP0000751_myopathy0.82633544
132MP0000537_abnormal_urethra_morphology0.82434459
133MP0002932_abnormal_joint_morphology0.82400066
134MP0005595_abnormal_vascular_smooth0.82085834
135MP0001270_distended_abdomen0.81038892
136MP0002928_abnormal_bile_duct0.80741367
137MP0000163_abnormal_cartilage_morphology0.80624130
138MP0002069_abnormal_eating/drinking_beha0.80013752
139MP0003137_abnormal_impulse_conducting0.79982238
140MP0002090_abnormal_vision0.79749742
141MP0002177_abnormal_outer_ear0.78556382
142MP0005409_darkened_coat_color0.77718199
143MP0009250_abnormal_appendicular_skeleto0.77705373
144MP0005187_abnormal_penis_morphology0.77456008
145MP0003385_abnormal_body_wall0.75757888
146MP0005551_abnormal_eye_electrophysiolog0.75475793
147MP0003942_abnormal_urinary_system0.75318970
148MP0000920_abnormal_myelination0.75080755
149MP0002089_abnormal_postnatal_growth/wei0.74477467
150MP0005167_abnormal_blood-brain_barrier0.73883826
151MP0000566_synostosis0.73417199
152MP0002638_abnormal_pupillary_reflex0.72735809
153MP0008789_abnormal_olfactory_epithelium0.70110948
154MP0004085_abnormal_heartbeat0.70104204
155MP0006072_abnormal_retinal_apoptosis0.68771857
156MP0010030_abnormal_orbit_morphology0.68719231
157MP0008961_abnormal_basal_metabolism0.68129283
158MP0002254_reproductive_system_inflammat0.67412136
159MP0002234_abnormal_pharynx_morphology0.66541925
160MP0003755_abnormal_palate_morphology0.66150071

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.62168474
2Myokymia (HP:0002411)5.05766507
3Megalencephaly (HP:0001355)4.43849491
4Focal seizures (HP:0007359)4.26242176
5Epileptic encephalopathy (HP:0200134)3.94750697
6Aplasia involving bones of the upper limbs (HP:0009823)3.94203195
7Aplasia of the phalanges of the hand (HP:0009802)3.94203195
8Aplasia involving bones of the extremities (HP:0009825)3.94203195
9Neurofibrillary tangles (HP:0002185)3.81476659
10Visual hallucinations (HP:0002367)3.71696002
11Cerebral inclusion bodies (HP:0100314)3.62236000
12Premature rupture of membranes (HP:0001788)3.48645100
13Hemiparesis (HP:0001269)3.41028540
14Supranuclear gaze palsy (HP:0000605)3.31426800
15Progressive cerebellar ataxia (HP:0002073)3.21098633
16Abnormality of binocular vision (HP:0011514)3.20104197
17Diplopia (HP:0000651)3.20104197
18Hyperacusis (HP:0010780)3.11405811
19Action tremor (HP:0002345)3.02863988
20Atrophic scars (HP:0001075)2.91293179
21Protrusio acetabuli (HP:0003179)2.85282712
22Broad-based gait (HP:0002136)2.82960810
23Generalized tonic-clonic seizures (HP:0002069)2.82875974
24Ulnar bowing (HP:0003031)2.81015112
25Atonic seizures (HP:0010819)2.79708592
26Broad metatarsal (HP:0001783)2.74210722
27Absence seizures (HP:0002121)2.70176221
28Neonatal short-limb short stature (HP:0008921)2.67239850
29Partial duplication of the phalanx of hand (HP:0009999)2.63557782
30Ankle contracture (HP:0006466)2.63339901
31Short nail (HP:0001799)2.62831287
32Partial duplication of thumb phalanx (HP:0009944)2.61820029
33Natal tooth (HP:0000695)2.58752360
34Hemiplegia (HP:0002301)2.56413390
35Hyperventilation (HP:0002883)2.55429909
36Dialeptic seizures (HP:0011146)2.52888217
37Abnormality of dentin (HP:0010299)2.51094825
38Dysdiadochokinesis (HP:0002075)2.50514310
39Missing ribs (HP:0000921)2.50499004
40Amblyopia (HP:0000646)2.49274190
41Renal duplication (HP:0000075)2.48210863
42Humeroradial synostosis (HP:0003041)2.45943333
43Synostosis involving the elbow (HP:0003938)2.45943333
44Febrile seizures (HP:0002373)2.42376254
45Poor eye contact (HP:0000817)2.40698346
46Depression (HP:0000716)2.40241916
47Septo-optic dysplasia (HP:0100842)2.40022757
48Bronchomalacia (HP:0002780)2.39865664
49Excessive salivation (HP:0003781)2.39742725
50Drooling (HP:0002307)2.39742725
51Spinal rigidity (HP:0003306)2.39513721
52Turricephaly (HP:0000262)2.38626164
53Mitral regurgitation (HP:0001653)2.35688456
54Ankle clonus (HP:0011448)2.34957493
55Abnormality of the 4th metacarpal (HP:0010012)2.33907175
56Obstructive sleep apnea (HP:0002870)2.33557780
57Abnormality of the phalanges of the hallux (HP:0010057)2.32609383
58Mutism (HP:0002300)2.30421885
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28952416
60Short 4th metacarpal (HP:0010044)2.28952416
61Elfin facies (HP:0004428)2.28234716
62Bladder diverticulum (HP:0000015)2.27589068
63Abnormal eating behavior (HP:0100738)2.27471434
64Tibial bowing (HP:0002982)2.24957037
65Genu recurvatum (HP:0002816)2.24084098
66Ankyloglossia (HP:0010296)2.23754865
67Urinary bladder sphincter dysfunction (HP:0002839)2.22326630
68Insidious onset (HP:0003587)2.22005705
69Termporal pattern (HP:0011008)2.22005705
70Impaired vibration sensation in the lower limbs (HP:0002166)2.21231713
71Genetic anticipation (HP:0003743)2.19096869
72Vascular tortuosity (HP:0004948)2.18376598
73Truncal ataxia (HP:0002078)2.17073843
74Abnormal social behavior (HP:0012433)2.16858057
75Impaired social interactions (HP:0000735)2.16858057
76Dysmetria (HP:0001310)2.14888073
77Arterial tortuosity (HP:0005116)2.14684140
78Stereotypic behavior (HP:0000733)2.14357320
79Limb dystonia (HP:0002451)2.13998123
80Arnold-Chiari malformation (HP:0002308)2.13842843
81Anxiety (HP:0000739)2.12967860
82Overriding aorta (HP:0002623)2.11644974
83Abnormality of the distal phalanx of the thumb (HP:0009617)2.11243593
84Amyotrophic lateral sclerosis (HP:0007354)2.09699475
85Abnormality of the diencephalon (HP:0010662)2.04464442
86Congenital glaucoma (HP:0001087)2.03974804
87Abnormality of the corticospinal tract (HP:0002492)2.03746299
88Clumsiness (HP:0002312)2.03273127
89Broad thumb (HP:0011304)2.02619526
90Papilledema (HP:0001085)2.02061739
91Bowed forearm bones (HP:0003956)2.00839122
92Bowing of the arm (HP:0006488)2.00839122
93Split foot (HP:0001839)1.99902421
94Fibular aplasia (HP:0002990)1.99628303
95Abnormality of the middle phalanges of the toes (HP:0010183)1.99098139
96Status epilepticus (HP:0002133)1.98395166
97Epileptiform EEG discharges (HP:0011182)1.97274805
98Coronal craniosynostosis (HP:0004440)1.96793796
99Urinary urgency (HP:0000012)1.96318619
100EEG with generalized epileptiform discharges (HP:0011198)1.95954269
101Deviation of the hallux (HP:0010051)1.94222650
102Insomnia (HP:0100785)1.91609828
103Fragile skin (HP:0001030)1.91267722
104Hypoventilation (HP:0002791)1.90792004
105Fragile nails (HP:0001808)1.90317301
106Hypsarrhythmia (HP:0002521)1.90301420
107Spastic gait (HP:0002064)1.89021888
108Aqueductal stenosis (HP:0002410)1.89005412
109Vertebral arch anomaly (HP:0008438)1.88995490
110Wide anterior fontanel (HP:0000260)1.88883705
111Infantile muscular hypotonia (HP:0008947)1.87463119
112Broad long bones (HP:0005622)1.87107391
113Hallux valgus (HP:0001822)1.87104428
114Broad phalanges of the hand (HP:0009768)1.86704678
115Shallow orbits (HP:0000586)1.86600222
116Apathy (HP:0000741)1.86465663
117Anophthalmia (HP:0000528)1.86188550
118Broad finger (HP:0001500)1.84906050
119Polyphagia (HP:0002591)1.84337352
120Thickened helices (HP:0000391)1.83779385
121Broad distal phalanx of finger (HP:0009836)1.82448445
122Preaxial foot polydactyly (HP:0001841)1.82340968
123Gaze-evoked nystagmus (HP:0000640)1.81679371
12411 pairs of ribs (HP:0000878)1.81111448
125Lower limb muscle weakness (HP:0007340)1.81064176
126Torticollis (HP:0000473)1.80927657
127Postural instability (HP:0002172)1.80645922
128Esophageal atresia (HP:0002032)1.80587425
129Cortical dysplasia (HP:0002539)1.77627177
130Absent speech (HP:0001344)1.77341302
131Broad phalanx (HP:0006009)1.77258107
132Abnormality of the antihelix (HP:0009738)1.77045131
133Vertebral clefting (HP:0008428)1.76293912
134Pointed chin (HP:0000307)1.75999724
135Annular pancreas (HP:0001734)1.75906747
136Fibular hypoplasia (HP:0003038)1.75744339
137Tracheomalacia (HP:0002779)1.74618088
138Abnormality of the distal phalanges of the toes (HP:0010182)1.73899463
139Trigonocephaly (HP:0000243)1.72953803
140Long palpebral fissure (HP:0000637)1.72329760
141Rib fusion (HP:0000902)1.72260342
142Narrow nasal bridge (HP:0000446)1.71386028
143Morphological abnormality of the middle ear (HP:0008609)1.70246148
144Lower limb asymmetry (HP:0100559)1.69714078
145Bradykinesia (HP:0002067)1.69414456
146Buphthalmos (HP:0000557)1.69144623
147High anterior hairline (HP:0009890)1.68543640
148Abnormality of oral frenula (HP:0000190)1.68313475
149Achilles tendon contracture (HP:0001771)1.68188875
150Generalized myoclonic seizures (HP:0002123)1.68114603
151Microglossia (HP:0000171)1.68113835
152Intention tremor (HP:0002080)1.67725422
153Vertebral hypoplasia (HP:0008417)1.67724324
154Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.67724324
155Abnormality of salivation (HP:0100755)1.66361862
156Long nose (HP:0003189)1.65180601
157Bowel diverticulosis (HP:0005222)1.64484250
158Focal dystonia (HP:0004373)1.63995234
159Cervical subluxation (HP:0003308)1.63737465
160Cutaneous finger syndactyly (HP:0010554)1.63426452
161Flat cornea (HP:0007720)1.62063699
162Protruding ear (HP:0000411)1.61454832
163Thin ribs (HP:0000883)1.60842174
164Agitation (HP:0000713)1.60840747
165Impaired smooth pursuit (HP:0007772)1.60722776
166Cutaneous syndactyly (HP:0012725)1.60713517
167Midface retrusion (HP:0011800)1.60007665
168Follicular hyperkeratosis (HP:0007502)1.58722284
169Mixed hearing impairment (HP:0000410)1.58227983
170Soft skin (HP:0000977)1.57527335
171Truncus arteriosus (HP:0001660)1.57156740
172Diminished motivation (HP:0000745)1.57110589
173Patellar dislocation (HP:0002999)1.57103720
174Hyperextensible skin (HP:0000974)1.56878234
175Wormian bones (HP:0002645)1.56412440
176Thin bony cortex (HP:0002753)1.56079057
177Oligodactyly (hands) (HP:0001180)1.55666807
178Broad hallux (HP:0010055)1.55393288
179Flattened epiphyses (HP:0003071)1.55312213
180Abnormality of the proximal phalanges of the hand (HP:0009834)1.54663647
181Renovascular hypertension (HP:0100817)1.54608971
182Abnormality of the lower motor neuron (HP:0002366)1.54573576
183Hyperthyroidism (HP:0000836)1.54476454
184Overgrowth (HP:0001548)1.52070182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.13402672
2MARK14.27347545
3NTRK33.54296710
4MAP3K93.19616408
5NTRK23.01192301
6MINK12.52321233
7TAF12.46368158
8PAK62.23168717
9MAP3K42.19885195
10TNIK2.17630366
11IRAK32.17601525
12CASK2.08360874
13DAPK22.02365797
14MOS2.02069342
15EPHA22.00361284
16PHKG21.83685021
17PHKG11.83685021
18PRKD31.81636812
19NTRK11.78172295
20STK38L1.78034962
21KSR11.76145286
22SIK11.73602861
23KSR21.70697134
24MAPK131.68688727
25PNCK1.67206669
26LIMK11.65430884
27MAP2K71.63457667
28LATS11.63420363
29LATS21.58329375
30SIK21.55804678
31TYRO31.55020190
32PIM21.53024906
33CDK51.52195252
34ERBB41.51661213
35ARAF1.39279041
36CAMKK11.37544065
37PRKCI1.34594334
38PLK21.33103095
39MET1.31872506
40MAP2K41.26367889
41MAP3K101.25461386
42UHMK11.24849485
43CAMK1D1.24032349
44STK241.23465016
45LMTK21.23436805
46TESK11.22387478
47PAK21.11613770
48PAK31.11098312
49PRKCG1.09352260
50TTN1.06630229
51CDK151.04266196
52NME21.02574767
53PRPF4B1.02309250
54CDK181.02162811
55MAPK150.98962816
56CDK140.98096331
57MAP3K20.97334434
58FGR0.96881378
59DYRK1A0.96086729
60BRAF0.95455221
61PAK40.94782423
62DDR20.93746904
63CAMK2A0.93649678
64GRK50.93103098
65AURKA0.92592754
66CSNK1G20.92411047
67CDK11A0.92138792
68RET0.90296512
69CDK190.89968741
70RIPK40.89926819
71RPS6KA20.89169241
72DYRK20.89021395
73STK110.87304816
74TAOK10.86302653
75FGFR20.85072319
76DAPK10.82866154
77CAMK1G0.82651896
78FES0.82377949
79SGK4940.81882390
80SGK2230.81882390
81MTOR0.80916375
82WEE10.79657008
83TRIB30.78536478
84EPHB20.77181706
85PDGFRA0.76935786
86CDK80.75269733
87ABL20.75130117
88MARK20.73315484
89STK380.71326217
90ALK0.71286528
91DYRK30.70776217
92PTK60.70543594
93ILK0.70504771
94PTK2B0.69687028
95PDGFRB0.68882673
96CAMK10.67910774
97MAP3K50.67752950
98DMPK0.65417336
99SGK10.63562672
100IRAK20.63456214
101MAP3K120.62796149
102CAMK2B0.62622027
103PKN20.62147320
104MAPK120.62113861
105EPHB10.62073000
106ROCK20.61869561
107SGK20.61747844
108MUSK0.59703269
109NEK20.59157898
110TAOK20.58468131
111STK30.57567608
112RIPK10.55964205
113PRKCH0.53688600
114ADRBK10.53490309
115DYRK1B0.53339919
116PKN10.52704835
117PRKCZ0.51698561
118OXSR10.51680798
119SGK30.51621262
120CAMK2G0.50442687
121FYN0.50210668
122NEK60.50149944
123RPS6KL10.50138799
124RPS6KC10.50138799
125MKNK20.49798598
126BUB10.49251360
127ROCK10.49124533
128PRKCE0.48615365
129ICK0.47686623
130RPS6KA30.46010068
131CDC42BPA0.45624907
132EPHA30.45046988
133TGFBR20.43537743
134FER0.43387847
135BCR0.42617788
136CDC70.41815706
137MAP3K130.41734982
138SMG10.41646392
139BMX0.41294787
140MAP2K10.40300858
141GSK3A0.39936087
142ERBB30.39464955
143MAPK100.39417771
144RPS6KA60.39161450
145FGFR10.38320015
146RAF10.37909797
147CHEK20.37782465
148PTK20.37753461
149CAMK2D0.37573670
150CSNK1G30.36481505
151NEK10.35884250
152BRSK10.35742103
153MAP3K60.35729817
154NME10.35650784
155CAMK40.34532828
156CSNK1A1L0.34003798
157SRC0.33896985
158CDK70.33075535
159GRK70.32774542

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38656155
2Glutamatergic synapse_Homo sapiens_hsa047242.58203786
3Nitrogen metabolism_Homo sapiens_hsa009102.56728178
4GABAergic synapse_Homo sapiens_hsa047272.51417992
5Circadian entrainment_Homo sapiens_hsa047132.43422717
6ECM-receptor interaction_Homo sapiens_hsa045122.39769800
7Synaptic vesicle cycle_Homo sapiens_hsa047212.37720573
8Long-term potentiation_Homo sapiens_hsa047202.34164274
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30899971
10Notch signaling pathway_Homo sapiens_hsa043302.30674119
11Morphine addiction_Homo sapiens_hsa050322.17598186
12Salivary secretion_Homo sapiens_hsa049702.16967747
13Olfactory transduction_Homo sapiens_hsa047402.16501480
14Amphetamine addiction_Homo sapiens_hsa050312.04116173
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01103767
16Gastric acid secretion_Homo sapiens_hsa049711.94214386
17Bladder cancer_Homo sapiens_hsa052191.88671111
18Dopaminergic synapse_Homo sapiens_hsa047281.84988274
19Insulin secretion_Homo sapiens_hsa049111.79916340
20Cholinergic synapse_Homo sapiens_hsa047251.72551771
21Cocaine addiction_Homo sapiens_hsa050301.72178679
22MicroRNAs in cancer_Homo sapiens_hsa052061.70737865
23Focal adhesion_Homo sapiens_hsa045101.67443246
24Axon guidance_Homo sapiens_hsa043601.66878126
25Long-term depression_Homo sapiens_hsa047301.64877820
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64061075
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59638523
28Renin secretion_Homo sapiens_hsa049241.58906163
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57107351
30Gap junction_Homo sapiens_hsa045401.55190091
31Taste transduction_Homo sapiens_hsa047421.49780930
32Serotonergic synapse_Homo sapiens_hsa047261.48911779
33Steroid biosynthesis_Homo sapiens_hsa001001.48238194
34Melanogenesis_Homo sapiens_hsa049161.45422224
35Oxytocin signaling pathway_Homo sapiens_hsa049211.45126186
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44420403
37Calcium signaling pathway_Homo sapiens_hsa040201.43455944
38Adherens junction_Homo sapiens_hsa045201.35570722
39GnRH signaling pathway_Homo sapiens_hsa049121.35094402
40TGF-beta signaling pathway_Homo sapiens_hsa043501.33305482
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30662950
42Fatty acid biosynthesis_Homo sapiens_hsa000611.29242755
43Dorso-ventral axis formation_Homo sapiens_hsa043201.28882810
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26822840
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26602296
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26141774
47Glioma_Homo sapiens_hsa052141.23650315
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21139442
49Pathways in cancer_Homo sapiens_hsa052001.20654187
50cAMP signaling pathway_Homo sapiens_hsa040241.20558267
51Estrogen signaling pathway_Homo sapiens_hsa049151.19997585
52Small cell lung cancer_Homo sapiens_hsa052221.19345291
53Chronic myeloid leukemia_Homo sapiens_hsa052201.14482726
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12349897
55ErbB signaling pathway_Homo sapiens_hsa040121.11698833
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.07585038
57Sulfur relay system_Homo sapiens_hsa041221.07399017
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05443185
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04942052
60PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02535270
61Amoebiasis_Homo sapiens_hsa051460.99978536
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.99905585
63Basal cell carcinoma_Homo sapiens_hsa052170.98290852
64p53 signaling pathway_Homo sapiens_hsa041150.98096887
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.95007424
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94592685
67Cardiac muscle contraction_Homo sapiens_hsa042600.94540313
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94077165
69Hedgehog signaling pathway_Homo sapiens_hsa043400.93629662
70Wnt signaling pathway_Homo sapiens_hsa043100.88565199
71Pancreatic secretion_Homo sapiens_hsa049720.86238538
72Dilated cardiomyopathy_Homo sapiens_hsa054140.85974682
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80195043
74AMPK signaling pathway_Homo sapiens_hsa041520.80061631
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79404961
76Oocyte meiosis_Homo sapiens_hsa041140.79246794
77Rap1 signaling pathway_Homo sapiens_hsa040150.78213301
78Salmonella infection_Homo sapiens_hsa051320.77509764
79Cell cycle_Homo sapiens_hsa041100.76685597
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76552741
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.76084150
82Thyroid hormone synthesis_Homo sapiens_hsa049180.75569952
83Type II diabetes mellitus_Homo sapiens_hsa049300.74376549
84Prostate cancer_Homo sapiens_hsa052150.74277299
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73486582
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73386298
87Renal cell carcinoma_Homo sapiens_hsa052110.72944041
88Hippo signaling pathway_Homo sapiens_hsa043900.72713044
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72042389
90Sulfur metabolism_Homo sapiens_hsa009200.71972093
91Collecting duct acid secretion_Homo sapiens_hsa049660.70836346
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.69791834
93Choline metabolism in cancer_Homo sapiens_hsa052310.69016444
94Endometrial cancer_Homo sapiens_hsa052130.68672099
95Pancreatic cancer_Homo sapiens_hsa052120.68431325
96Prolactin signaling pathway_Homo sapiens_hsa049170.67825271
97Bile secretion_Homo sapiens_hsa049760.65678285
98Protein digestion and absorption_Homo sapiens_hsa049740.65193704
99MAPK signaling pathway_Homo sapiens_hsa040100.64599468
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.63186514
101Ras signaling pathway_Homo sapiens_hsa040140.63121029
102Sphingolipid metabolism_Homo sapiens_hsa006000.62808166
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60091679
104VEGF signaling pathway_Homo sapiens_hsa043700.59356239
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58283835
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58108477
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57396712
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57378007
109Alcoholism_Homo sapiens_hsa050340.55883603
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54138216
111TNF signaling pathway_Homo sapiens_hsa046680.53539367
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52724511
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52305268
114Colorectal cancer_Homo sapiens_hsa052100.52223961
115Glucagon signaling pathway_Homo sapiens_hsa049220.51645939
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51153347
117mTOR signaling pathway_Homo sapiens_hsa041500.49326815
118Thyroid cancer_Homo sapiens_hsa052160.49122594
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48402238
120Phototransduction_Homo sapiens_hsa047440.47447975
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46948705
122Prion diseases_Homo sapiens_hsa050200.46868670
123Vibrio cholerae infection_Homo sapiens_hsa051100.45454965
124Circadian rhythm_Homo sapiens_hsa047100.44984883
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44840671
126Vitamin B6 metabolism_Homo sapiens_hsa007500.42964422
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42962105
128Tight junction_Homo sapiens_hsa045300.42953064
129Proteoglycans in cancer_Homo sapiens_hsa052050.42408001
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41264263
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40886300
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40794022
133African trypanosomiasis_Homo sapiens_hsa051430.40777207
134Non-small cell lung cancer_Homo sapiens_hsa052230.40275410
135Melanoma_Homo sapiens_hsa052180.40031206
136Apoptosis_Homo sapiens_hsa042100.39845125
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39413697
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39005440
139HTLV-I infection_Homo sapiens_hsa051660.38393048
140FoxO signaling pathway_Homo sapiens_hsa040680.38180127
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37185600
142Folate biosynthesis_Homo sapiens_hsa007900.37133655
143Insulin signaling pathway_Homo sapiens_hsa049100.36363701

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »