FKBP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.02314110
2chondrocyte proliferation (GO:0035988)4.89386684
3protein heterotrimerization (GO:0070208)4.77751822
4cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.73513018
5chondrocyte development (GO:0002063)4.40012662
6bone trabecula formation (GO:0060346)4.37130071
7positive regulation of extracellular matrix organization (GO:1903055)4.27675942
8omega-hydroxylase P450 pathway (GO:0097267)4.17634008
9epoxygenase P450 pathway (GO:0019373)4.03613231
10keratan sulfate catabolic process (GO:0042340)3.92680486
11sequestering of extracellular ligand from receptor (GO:0035581)3.85325484
12collagen metabolic process (GO:0032963)3.83866238
13collagen catabolic process (GO:0030574)3.82579934
14negative regulation of chondrocyte differentiation (GO:0032331)3.78773598
15multicellular organismal macromolecule metabolic process (GO:0044259)3.60912922
16retina vasculature morphogenesis in camera-type eye (GO:0061299)3.55261057
17multicellular organismal catabolic process (GO:0044243)3.50736067
18multicellular organismal metabolic process (GO:0044236)3.44009632
19skin morphogenesis (GO:0043589)3.38010574
20UDP-N-acetylglucosamine metabolic process (GO:0006047)3.35807657
21pericardium development (GO:0060039)3.34842954
22negative regulation of axon extension involved in axon guidance (GO:0048843)3.34682845
23dermatan sulfate biosynthetic process (GO:0030208)3.33375678
24cell aggregation (GO:0098743)3.30979496
25cartilage condensation (GO:0001502)3.30979496
26negative regulation of axon guidance (GO:1902668)3.29895591
27endodermal cell differentiation (GO:0035987)3.29148393
28mesenchymal-epithelial cell signaling (GO:0060638)3.19590342
29extracellular matrix disassembly (GO:0022617)3.19204193
30lymphangiogenesis (GO:0001946)3.17450417
31negative regulation of cartilage development (GO:0061037)3.13359709
32G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.10037359
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.07994363
34dermatan sulfate metabolic process (GO:0030205)3.03481375
35peptidyl-proline hydroxylation (GO:0019511)3.02675086
36regulation of hippo signaling (GO:0035330)3.02069497
37craniofacial suture morphogenesis (GO:0097094)3.00125878
38protein retention in ER lumen (GO:0006621)2.99717346
39chondroitin sulfate biosynthetic process (GO:0030206)2.93183449
40endothelial cell morphogenesis (GO:0001886)2.92201779
41glomerular basement membrane development (GO:0032836)2.84792224
42positive regulation of cartilage development (GO:0061036)2.84235534
43extracellular fibril organization (GO:0043206)2.83780299
44extracellular matrix organization (GO:0030198)2.83244993
45embryonic skeletal joint morphogenesis (GO:0060272)2.82844491
46extracellular structure organization (GO:0043062)2.82337113
47axon extension involved in axon guidance (GO:0048846)2.81074319
48neuron projection extension involved in neuron projection guidance (GO:1902284)2.81074319
49regulation of non-canonical Wnt signaling pathway (GO:2000050)2.79990506
50endochondral ossification (GO:0001958)2.79602481
51replacement ossification (GO:0036075)2.79602481
52metanephric mesenchyme development (GO:0072075)2.79520405
53endocardial cushion morphogenesis (GO:0003203)2.76481695
54negative regulation of catenin import into nucleus (GO:0035414)2.76104302
55wound healing, spreading of epidermal cells (GO:0035313)2.75041939
56neural crest cell development (GO:0014032)2.71992979
57cartilage development (GO:0051216)2.69191677
58mesenchyme morphogenesis (GO:0072132)2.68806877
59regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.66818970
60kidney mesenchyme development (GO:0072074)2.66519747
61cell adhesion mediated by integrin (GO:0033627)2.66197675
62cellular response to vitamin D (GO:0071305)2.65925264
63substrate adhesion-dependent cell spreading (GO:0034446)2.65661545
64extracellular negative regulation of signal transduction (GO:1900116)2.65539858
65extracellular regulation of signal transduction (GO:1900115)2.65539858
66signal peptide processing (GO:0006465)2.65451715
67regulation of steroid hormone biosynthetic process (GO:0090030)2.65438401
68artery development (GO:0060840)2.65320510
69extracellular matrix assembly (GO:0085029)2.64446603
70type B pancreatic cell proliferation (GO:0044342)2.64352932
71regulation of chondrocyte differentiation (GO:0032330)2.63385134
72regulation of extracellular matrix disassembly (GO:0010715)2.61844984
73regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61636266
74endocardial cushion development (GO:0003197)2.61495701
75regulation of extracellular matrix organization (GO:1903053)2.60720000
76hemidesmosome assembly (GO:0031581)2.60080554
77regulation of transforming growth factor beta2 production (GO:0032909)2.59624777
78regulation of cartilage development (GO:0061035)2.57507280
79negative regulation of keratinocyte proliferation (GO:0010839)2.56224124
80basement membrane organization (GO:0071711)2.55750211
81smooth muscle tissue development (GO:0048745)2.55357670
82positive regulation of mesenchymal cell proliferation (GO:0002053)2.55041921
83regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.54981534
84positive regulation of osteoblast proliferation (GO:0033690)2.54490070
85trabecula formation (GO:0060343)2.53141386
86negative chemotaxis (GO:0050919)2.53114130
87anterior/posterior axis specification, embryo (GO:0008595)2.51300839
88toxin metabolic process (GO:0009404)2.50489735
89regulation of integrin-mediated signaling pathway (GO:2001044)2.49838459
90epithelial to mesenchymal transition (GO:0001837)2.49834467
91protein hydroxylation (GO:0018126)2.49736383
92cranial suture morphogenesis (GO:0060363)2.49664791
93cardiac epithelial to mesenchymal transition (GO:0060317)2.48867182
94hippo signaling (GO:0035329)2.48395585
95limb bud formation (GO:0060174)2.47997265
96regulation of mesenchymal cell proliferation (GO:0010464)2.47444628
97notochord development (GO:0030903)2.47430829
98positive regulation of glycogen biosynthetic process (GO:0045725)2.46996185
99regulation of axon extension involved in axon guidance (GO:0048841)2.45049035
100type B pancreatic cell development (GO:0003323)2.44920768
101nucleotide-sugar biosynthetic process (GO:0009226)2.43988426
102dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.43511758
103cell migration involved in sprouting angiogenesis (GO:0002042)2.42756225
104negative regulation of fatty acid transport (GO:2000192)2.42674651
105lipopolysaccharide biosynthetic process (GO:0009103)2.41711772
106response to gravity (GO:0009629)2.39570355
107peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.39545222
108camera-type eye morphogenesis (GO:0048593)2.39357544
109ossification (GO:0001503)2.37710478
110myelination in peripheral nervous system (GO:0022011)2.37645575
111peripheral nervous system axon ensheathment (GO:0032292)2.37645575
112organ induction (GO:0001759)2.36850719
113nucleotide transmembrane transport (GO:1901679)2.36382841
114cellular response to vitamin (GO:0071295)2.36044419
115chondroitin sulfate metabolic process (GO:0030204)2.34971330
116COPII vesicle coating (GO:0048208)2.34531158
117COPI coating of Golgi vesicle (GO:0048205)2.33599801
118Golgi transport vesicle coating (GO:0048200)2.33599801
119regulation of axon guidance (GO:1902667)2.32923504
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.32498278
121regulation of glucocorticoid metabolic process (GO:0031943)2.31830932
122regulation of organ formation (GO:0003156)2.31263309
123mesodermal cell differentiation (GO:0048333)2.31185705
124regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.30865738
125glycosaminoglycan biosynthetic process (GO:0006024)2.30790456
126embryonic foregut morphogenesis (GO:0048617)2.30746440
127positive regulation of protein autophosphorylation (GO:0031954)2.30731415
128endosome to melanosome transport (GO:0035646)2.30254831
129endosome to pigment granule transport (GO:0043485)2.30254831
130substrate-dependent cell migration (GO:0006929)2.29965609
131platelet dense granule organization (GO:0060155)2.29548812
132positive regulation of hormone biosynthetic process (GO:0046886)2.29111388
133regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.29028670
134skeletal system development (GO:0001501)2.28656492
135cell migration involved in heart development (GO:0060973)2.28410194
136outer ear morphogenesis (GO:0042473)2.27501865
137epithelial cell-cell adhesion (GO:0090136)2.27397287
138aminoglycan biosynthetic process (GO:0006023)2.27175428
139mesenchymal cell proliferation (GO:0010463)2.27163158
140cochlea morphogenesis (GO:0090103)2.26215346
141response to redox state (GO:0051775)2.25158989
142heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.24481872
143activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.23674270
144regulation of keratinocyte proliferation (GO:0010837)2.23604790
145negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.23085686
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.19278612
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.18858397
148negative regulation of BMP signaling pathway (GO:0030514)2.17770727
149embryonic forelimb morphogenesis (GO:0035115)2.16956027
150embryonic cranial skeleton morphogenesis (GO:0048701)2.16068991
151organ formation (GO:0048645)2.15024816
152lipid particle organization (GO:0034389)2.12268006
153nucleotide-sugar metabolic process (GO:0009225)2.11165771
154positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.11052377
155polarized epithelial cell differentiation (GO:0030859)2.10552223
156response to pheromone (GO:0019236)2.08495687
157ventricular septum development (GO:0003281)2.08442046
158regulation of mesoderm development (GO:2000380)2.08396267
159maturation of 5.8S rRNA (GO:0000460)2.08169074
160ganglion development (GO:0061548)2.07763414
161cornea development in camera-type eye (GO:0061303)2.06237256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.13607831
2SALL1_21062744_ChIP-ChIP_HESCs_Human2.80866750
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.57359682
4EED_16625203_ChIP-ChIP_MESCs_Mouse2.49653744
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40366007
6GBX2_23144817_ChIP-Seq_PC3_Human2.38948634
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34072324
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25948689
9* WT1_19549856_ChIP-ChIP_CCG9911_Human2.25025280
10EWS_26573619_Chip-Seq_HEK293_Human2.22123122
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21183412
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21183412
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20224910
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17086727
15ZNF274_21170338_ChIP-Seq_K562_Hela2.15662929
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14158063
17ELK1_19687146_ChIP-ChIP_HELA_Human2.08700459
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.06120381
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03797719
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03232363
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.01113965
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98882204
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.98010082
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96664040
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96024702
26VDR_22108803_ChIP-Seq_LS180_Human1.94998525
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.92059229
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.92059229
29CJUN_26792858_Chip-Seq_BT549_Human1.91997209
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.90359081
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89835160
32CLOCK_20551151_ChIP-Seq_293T_Human1.88725997
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88505237
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.84680913
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83952029
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83904375
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.82097229
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75820190
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71428841
40AR_21572438_ChIP-Seq_LNCaP_Human1.70867776
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67087516
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.65708446
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65012410
44TP53_18474530_ChIP-ChIP_U2OS_Human1.62269541
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.57041494
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56278922
47IGF1R_20145208_ChIP-Seq_DFB_Human1.53759442
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.49707276
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.47358309
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46149128
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45843949
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45710851
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44883593
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42786623
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.42771181
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42416507
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42162570
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41665418
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41326954
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40447762
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39930422
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39380990
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38055421
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.37927156
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37300031
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37084471
67ER_23166858_ChIP-Seq_MCF-7_Human1.35681892
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.34401349
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34075421
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.32325676
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.30313106
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30055169
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.29304471
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29168465
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.26730001
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26107819
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25616868
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25297240
79BRD4_25478319_ChIP-Seq_HGPS_Human1.23175900
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21964312
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20497484
82CBP_20019798_ChIP-Seq_JUKART_Human1.20156387
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20156387
84* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19757154
85SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.19541569
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19239756
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17861690
88SMAD4_21799915_ChIP-Seq_A2780_Human1.17819085
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.17555860
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.16544735
91* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16377011
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15753252
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15732702
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15249957
95P300_19829295_ChIP-Seq_ESCs_Human1.14524328
96JUN_21703547_ChIP-Seq_K562_Human1.14295395
97EST1_17652178_ChIP-ChIP_JURKAT_Human1.14285882
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14057236
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13290960
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.12546830
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12004337
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11587370
103TCF4_23295773_ChIP-Seq_U87_Human1.10826524
104P53_22387025_ChIP-Seq_ESCs_Mouse1.10820347
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.09924439
106SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08327660
107* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08027086
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08026439
109CDX2_22108803_ChIP-Seq_LS180_Human1.07785006
110RXR_22108803_ChIP-Seq_LS180_Human1.06785612
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06612294
112AHR_22903824_ChIP-Seq_MCF-7_Human1.06346160
113TCF4_22108803_ChIP-Seq_LS180_Human1.05877372
114TP53_16413492_ChIP-PET_HCT116_Human1.05846505
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05748732
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.05507668
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05076334
118EZH2_22144423_ChIP-Seq_EOC_Human1.04780929
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.04467462
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03704054
121BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03462413
122MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03193716
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02655859
124* ISL1_27105846_Chip-Seq_CPCs_Mouse1.01829388
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01817065
126AR_21909140_ChIP-Seq_LNCAP_Human1.00904522
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.00523315
128DROSHA_22980978_ChIP-Seq_HELA_Human1.00387582
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00359350
130ELK1_22589737_ChIP-Seq_MCF10A_Human0.99931212
131PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99815574
132* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99368111
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99148883
134BCAT_22108803_ChIP-Seq_LS180_Human0.98854635
135SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98647948
136MYC_18940864_ChIP-ChIP_HL60_Human0.98518673
137FUS_26573619_Chip-Seq_HEK293_Human0.98463001
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.98017015
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97966172
140* RING1B_27294783_Chip-Seq_NPCs_Mouse0.96868389
141AR_25329375_ChIP-Seq_VCAP_Human0.96736898
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95061765
143* SOX2_20726797_ChIP-Seq_SW620_Human0.94048647
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93245094
145ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92399857
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.92309146
147PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91770115
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90800803
149STAT3_23295773_ChIP-Seq_U87_Human0.90464053
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.88687532
151TAF15_26573619_Chip-Seq_HEK293_Human0.88668471
152SA1_22415368_ChIP-Seq_MEFs_Mouse0.88195751
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86296098
154NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86170763
155PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86128865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.99822738
2MP0005503_abnormal_tendon_morphology5.74587150
3MP0005275_abnormal_skin_tensile4.28408045
4MP0003279_aneurysm3.52585059
5MP0004272_abnormal_basement_membrane3.18474485
6MP0009384_cardiac_valve_regurgitation3.12516499
7MP0001958_emphysema2.65525901
8MP0003705_abnormal_hypodermis_morpholog2.63382506
9MP0009250_abnormal_appendicular_skeleto2.59599324
10MP0005623_abnormal_meninges_morphology2.34669041
11MP0005508_abnormal_skeleton_morphology2.32990232
12MP0004134_abnormal_chest_morphology2.15665243
13MP0002282_abnormal_trachea_morphology2.12920810
14MP0001299_abnormal_eye_distance/2.04723938
15MP0002108_abnormal_muscle_morphology1.94992439
16MP0001542_abnormal_bone_strength1.94627197
17MP0002295_abnormal_pulmonary_circulatio1.93891829
18MP0003385_abnormal_body_wall1.93290824
19MP0006054_spinal_hemorrhage1.91345091
20MP0002896_abnormal_bone_mineralization1.85854522
21MP0005257_abnormal_intraocular_pressure1.82695646
22MP0000013_abnormal_adipose_tissue1.82319779
23MP0005171_absent_coat_pigmentation1.81548193
24MP0000534_abnormal_ureter_morphology1.79650695
25MP0000163_abnormal_cartilage_morphology1.75512274
26MP0010030_abnormal_orbit_morphology1.73455530
27MP0000569_abnormal_digit_pigmentation1.72874417
28MP0003122_maternal_imprinting1.61171552
29MP0002102_abnormal_ear_morphology1.60864617
30MP0002115_abnormal_skeleton_extremities1.60455689
31MP0003283_abnormal_digestive_organ1.47290857
32MP0003942_abnormal_urinary_system1.47161820
33MP0009780_abnormal_chondrocyte_physiolo1.46115622
34MP0000751_myopathy1.43386949
35MP0005408_hypopigmentation1.39644005
36MP0002249_abnormal_larynx_morphology1.39483778
37MP0002933_joint_inflammation1.39218150
38MP0005248_abnormal_Harderian_gland1.39029129
39MP0002160_abnormal_reproductive_system1.38607526
40MP0009697_abnormal_copulation1.37390231
41MP0002234_abnormal_pharynx_morphology1.35352964
42MP0002938_white_spotting1.34075592
43MP0000762_abnormal_tongue_morphology1.28664550
44MP0002932_abnormal_joint_morphology1.23204004
45MP0000427_abnormal_hair_cycle1.21167484
46MP0002233_abnormal_nose_morphology1.20726466
47MP0000049_abnormal_middle_ear1.20201174
48MP0003136_yellow_coat_color1.18750311
49MP0002113_abnormal_skeleton_development1.18084860
50MP0000767_abnormal_smooth_muscle1.16951995
51MP0005390_skeleton_phenotype1.16299587
52MP0002060_abnormal_skin_morphology1.15614050
53MP0010368_abnormal_lymphatic_system1.14033352
54MP0002109_abnormal_limb_morphology1.11767133
55MP0003755_abnormal_palate_morphology1.09606650
56MP0010386_abnormal_urinary_bladder1.08875907
57MP0002116_abnormal_craniofacial_bone1.08870798
58MP0003937_abnormal_limbs/digits/tail_de1.07301193
59MP0002089_abnormal_postnatal_growth/wei1.04202690
60MP0000428_abnormal_craniofacial_morphol1.03721777
61MP0003115_abnormal_respiratory_system1.02961484
62MP0002837_dystrophic_cardiac_calcinosis1.00994122
63MP0000516_abnormal_urinary_system1.00823551
64MP0005367_renal/urinary_system_phenotyp1.00823551
65MP0001879_abnormal_lymphatic_vessel0.99831187
66MP0000003_abnormal_adipose_tissue0.98246200
67MP0003566_abnormal_cell_adhesion0.97748670
68MP0003091_abnormal_cell_migration0.96888459
69MP0000613_abnormal_salivary_gland0.96538689
70MP0004084_abnormal_cardiac_muscle0.95029267
71MP0000538_abnormal_urinary_bladder0.94994107
72MP0001286_abnormal_eye_development0.94198036
73MP0001177_atelectasis0.93366063
74MP0000462_abnormal_digestive_system0.93192563
75MP0006138_congestive_heart_failure0.92673358
76MP0002168_other_aberrant_phenotype0.92630357
77MP0000432_abnormal_head_morphology0.92291907
78MP0003119_abnormal_digestive_system0.91710191
79MP0005023_abnormal_wound_healing0.91434825
80MP0005595_abnormal_vascular_smooth0.90957927
81MP0001293_anophthalmia0.89631427
82MP0009053_abnormal_anal_canal0.89170812
83MP0000372_irregular_coat_pigmentation0.85461257
84MP0003718_maternal_effect0.85351261
85MP0006072_abnormal_retinal_apoptosis0.84667209
86MP0003935_abnormal_craniofacial_develop0.83616504
87MP0000749_muscle_degeneration0.83312512
88MP0000647_abnormal_sebaceous_gland0.81895624
89MP0004133_heterotaxia0.81675292
90MP0002998_abnormal_bone_remodeling0.81182107
91MP0005388_respiratory_system_phenotype0.80239878
92MP0002133_abnormal_respiratory_system0.80239878
93MP0005670_abnormal_white_adipose0.80048720
94MP0003195_calcinosis0.79656128
95MP0010352_gastrointestinal_tract_polyps0.78978937
96MP0001270_distended_abdomen0.78303442
97MP0002254_reproductive_system_inflammat0.77077079
98MP0005174_abnormal_tail_pigmentation0.75222700
99MP0005187_abnormal_penis_morphology0.75048986
100MP0002114_abnormal_axial_skeleton0.74341879
101MP0005197_abnormal_uvea_morphology0.73940823
102MP0001243_abnormal_dermal_layer0.73765098
103MP0008775_abnormal_heart_ventricle0.73528540
104MP0003890_abnormal_embryonic-extraembry0.73096958
105MP0002128_abnormal_blood_circulation0.72277848
106MP0000747_muscle_weakness0.71703485
107MP0008932_abnormal_embryonic_tissue0.71497361
108MP0003950_abnormal_plasma_membrane0.71154927
109MP0003795_abnormal_bone_structure0.71097680
110MP0005395_other_phenotype0.71002431
111MP0003186_abnormal_redox_activity0.70478443
112MP0005389_reproductive_system_phenotype0.70391931
113MP0002111_abnormal_tail_morphology0.69936096
114MP0002084_abnormal_developmental_patter0.69903278
115MP0000383_abnormal_hair_follicle0.67666021
116MP0000733_abnormal_muscle_development0.67035911
117MP0005193_abnormal_anterior_eye0.66318874
118MP0005369_muscle_phenotype0.65448200
119MP0000579_abnormal_nail_morphology0.63652913
120MP0004036_abnormal_muscle_relaxation0.63280704
121MP0002177_abnormal_outer_ear0.63118669
122MP0005253_abnormal_eye_physiology0.62581790
123MP0000537_abnormal_urethra_morphology0.61843299
124MP0002751_abnormal_autonomic_nervous0.61697172
125MP0001614_abnormal_blood_vessel0.60465400
126MP0004233_abnormal_muscle_weight0.60416999
127MP0001340_abnormal_eyelid_morphology0.60307337
128MP0002697_abnormal_eye_size0.59754795
129MP0005375_adipose_tissue_phenotype0.59153753
130MP0002972_abnormal_cardiac_muscle0.57989186
131MP0004087_abnormal_muscle_fiber0.57873111
132MP0005620_abnormal_muscle_contractility0.56859468
133MP0003941_abnormal_skin_development0.56087917
134MP0005164_abnormal_response_to0.55681714

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.55876463
2Premature rupture of membranes (HP:0001788)6.10938751
3Neonatal short-limb short stature (HP:0008921)4.64440933
4Abnormality of dentin (HP:0010299)3.99568473
5Aortic dissection (HP:0002647)3.79817670
6Epiphyseal dysplasia (HP:0002656)3.74477988
7* Soft skin (HP:0000977)3.73544661
8Broad metatarsal (HP:0001783)3.71591289
9Hypoplastic ischia (HP:0003175)3.52804533
10Ankle contracture (HP:0006466)3.38502721
11Atrophic scars (HP:0001075)3.37449951
12Abnormality of the ischium (HP:0003174)3.34942315
13Cervical subluxation (HP:0003308)3.33467077
14Shallow orbits (HP:0000586)3.33220274
15Cupped ribs (HP:0000887)3.29697674
16Increased corneal curvature (HP:0100692)3.29064490
17Keratoconus (HP:0000563)3.29064490
18Wormian bones (HP:0002645)3.26574749
19* Follicular hyperkeratosis (HP:0007502)3.25404591
20Osteoarthritis (HP:0002758)3.17284140
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.17041412
22Vitreoretinal degeneration (HP:0000655)3.11204212
23Biconcave vertebral bodies (HP:0004586)2.99282188
24Aortic aneurysm (HP:0004942)2.92529658
25Peritonitis (HP:0002586)2.85218565
26Blue sclerae (HP:0000592)2.83919296
27Vascular tortuosity (HP:0004948)2.83731209
28Infantile muscular hypotonia (HP:0008947)2.79340012
29* Bladder diverticulum (HP:0000015)2.76428019
30Overgrowth (HP:0001548)2.72858470
31Spinal rigidity (HP:0003306)2.72833945
32Mild short stature (HP:0003502)2.69935959
33Type 1 muscle fiber predominance (HP:0003803)2.69919991
34Arterial tortuosity (HP:0005116)2.69326645
35Fragile skin (HP:0001030)2.62034168
36Irregular epiphyses (HP:0010582)2.61545976
37Genu recurvatum (HP:0002816)2.61504107
38Small epiphyses (HP:0010585)2.53504894
39Cerebral aneurysm (HP:0004944)2.53061618
40Mitral valve prolapse (HP:0001634)2.49246044
41Broad ribs (HP:0000885)2.47983046
42Increased variability in muscle fiber diameter (HP:0003557)2.45455586
43Flat capital femoral epiphysis (HP:0003370)2.44155681
44* Hyperextensible skin (HP:0000974)2.41744318
45Broad long bones (HP:0005622)2.41549195
46Bell-shaped thorax (HP:0001591)2.40649360
47Dilatation of the ascending aorta (HP:0005111)2.40537205
48Buphthalmos (HP:0000557)2.39322269
49Coxa vara (HP:0002812)2.39105041
50Platyspondyly (HP:0000926)2.38115023
51Pancreatic cysts (HP:0001737)2.34552547
52Delayed gross motor development (HP:0002194)2.32783876
53Coronal craniosynostosis (HP:0004440)2.31921321
54Wide anterior fontanel (HP:0000260)2.31911567
55Exostoses (HP:0100777)2.26013115
56Slender build (HP:0001533)2.24894555
57Vertebral compression fractures (HP:0002953)2.23803296
58Hypoventilation (HP:0002791)2.23105537
59Ectopia lentis (HP:0001083)2.22593668
60Limited hip movement (HP:0008800)2.20824384
61Aplasia involving bones of the extremities (HP:0009825)2.20275400
62Aplasia involving bones of the upper limbs (HP:0009823)2.20275400
63Aplasia of the phalanges of the hand (HP:0009802)2.20275400
64Bowel diverticulosis (HP:0005222)2.19216160
65Metaphyseal cupping (HP:0003021)2.16748948
66Knee flexion contracture (HP:0006380)2.15120733
67Fibular hypoplasia (HP:0003038)2.14235378
68Mesomelia (HP:0003027)2.13732727
69Hip contracture (HP:0003273)2.11268808
70Tibial bowing (HP:0002982)2.08967551
71Delayed epiphyseal ossification (HP:0002663)2.08140268
72Abnormal delivery (HP:0001787)2.08043043
73Pancreatic fibrosis (HP:0100732)2.07735781
74Cardiovascular calcification (HP:0011915)2.06990688
75Abnormal tarsal ossification (HP:0008369)2.06719257
76Abnormality of the acetabulum (HP:0003170)2.06668160
77Joint laxity (HP:0001388)2.06432933
78True hermaphroditism (HP:0010459)2.06296032
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.03751029
80Elbow flexion contracture (HP:0002987)2.03489995
81Hypoplasia of the iris (HP:0007676)2.03406727
82Increased number of teeth (HP:0011069)2.03042692
83Femoral bowing (HP:0002980)2.02790112
84Abnormality of carpal bone ossification (HP:0006257)2.01965413
85Redundant skin (HP:0001582)2.01841663
86Broad phalanx (HP:0006009)2.00899831
87Abnormality of the vertebral endplates (HP:0005106)2.00599183
88Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00251706
89Abnormality of skeletal muscle fiber size (HP:0012084)1.99884926
90Irregular vertebral endplates (HP:0003301)1.99235370
91Tubular atrophy (HP:0000092)1.93744865
92Abnormal vertebral ossification (HP:0100569)1.93573227
93Spinal cord compression (HP:0002176)1.92692365
94Abnormality of midbrain morphology (HP:0002418)1.90330883
95Molar tooth sign on MRI (HP:0002419)1.90330883
96Asymmetry of the thorax (HP:0001555)1.89989156
97Aortic valve stenosis (HP:0001650)1.89927749
98Nephronophthisis (HP:0000090)1.89653420
99Short hallux (HP:0010109)1.89387042
100Abnormality of the 2nd finger (HP:0004100)1.88942337
101Flattened epiphyses (HP:0003071)1.86579005
102Chorioretinal atrophy (HP:0000533)1.86421174
103Morphological abnormality of the middle ear (HP:0008609)1.86085082
104Bifid tongue (HP:0010297)1.84845577
105Congenital glaucoma (HP:0001087)1.84597018
106Mildly elevated creatine phosphokinase (HP:0008180)1.84550795
107Wrist flexion contracture (HP:0001239)1.84282089
108Aplasia/Hypoplasia of the fibula (HP:0006492)1.84162234
109Nonimmune hydrops fetalis (HP:0001790)1.82928982
110Small hand (HP:0200055)1.81768331
111Microglossia (HP:0000171)1.81073956
112Ulnar bowing (HP:0003031)1.79106662
113Abnormality of the middle phalanges of the toes (HP:0010183)1.78396190
114Abnormality of the renal medulla (HP:0100957)1.77966984
115Congenital, generalized hypertrichosis (HP:0004540)1.77954261
116Abnormal ossification of hand bones (HP:0005921)1.76875340
117Flat acetabular roof (HP:0003180)1.76701476
118Aortic regurgitation (HP:0001659)1.75886126
119Genu varum (HP:0002970)1.75050299
120Short tibia (HP:0005736)1.74705465
121Abnormality of the pubic bones (HP:0003172)1.73855578
122Abnormality of the anterior chamber (HP:0000593)1.72892722
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.72447116
124Ovoid vertebral bodies (HP:0003300)1.71274365
125Decreased skull ossification (HP:0004331)1.71035701
126Spondylolisthesis (HP:0003302)1.70001469
127Abnormality of the vitreous humor (HP:0004327)1.69900731
128Short nail (HP:0001799)1.63547342
129Breech presentation (HP:0001623)1.62976337
130Disproportionate short-trunk short stature (HP:0003521)1.62332669
131Abnormal protein glycosylation (HP:0012346)1.62180968
132Abnormal glycosylation (HP:0012345)1.62180968
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62180968
134Abnormal protein N-linked glycosylation (HP:0012347)1.62180968
135Pterygium (HP:0001059)1.61363163
136Type I transferrin isoform profile (HP:0003642)1.59191270
137Metaphyseal dysplasia (HP:0100255)1.57999655
138Cerebellar dysplasia (HP:0007033)1.57004124
139Protruding ear (HP:0000411)1.55616818
140Medial flaring of the eyebrow (HP:0010747)1.54009874
141Hypoplastic labia majora (HP:0000059)1.53417656
142Occipital encephalocele (HP:0002085)1.53143490
143Delayed closure of the anterior fontanelle (HP:0001476)1.52695290
144Mitral stenosis (HP:0001718)1.49724930
145Hypoplasia of the fovea (HP:0007750)1.49615473
146Aplasia/Hypoplasia of the fovea (HP:0008060)1.49615473
147Abnormality of the renal cortex (HP:0011035)1.49146159
148Renal duplication (HP:0000075)1.48972031
149Entropion (HP:0000621)1.48151452
150Abnormality of the labia majora (HP:0012881)1.43652031
151Preaxial foot polydactyly (HP:0001841)1.43064127
152Pulmonary artery stenosis (HP:0004415)1.41857279
153Cystic liver disease (HP:0006706)1.41545488

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.21316834
2LATS13.10555997
3PDGFRA2.94948446
4BRSK22.64373703
5NUAK12.61684324
6SIK12.54078355
7PAK32.46831645
8LATS22.39946796
9BMPR1B2.26560066
10CAMK1G2.25949127
11FER1.97182151
12INSRR1.94077291
13PTK2B1.85956128
14NEK11.82668156
15WEE11.80928366
16MET1.75804028
17TTN1.74969101
18EIF2AK31.73277882
19PLK21.69571328
20EPHB21.65294391
21STK38L1.63794448
22EIF2AK11.62079377
23STK391.60350842
24CAMK1D1.55291985
25NTRK11.52784156
26GRK11.51359863
27PIK3CA1.49166204
28PAK21.49125643
29EPHA31.48994406
30WNK41.47566909
31PRKD31.44878444
32TRIB31.42346207
33ADRBK21.41869213
34AKT31.35649820
35ROCK11.34915443
36FGFR21.33962033
37ZAK1.33321787
38BUB11.33259358
39MYLK1.33230019
40TGFBR11.32958608
41TRIM281.28545689
42PNCK1.27626794
43WNK31.26961725
44PKN21.23204726
45PLK31.22898088
46PDGFRB1.22358903
47PTK21.20627326
48MKNK21.19426031
49FGFR11.17957167
50ACVR1B1.17345073
51LIMK11.15272919
52TNIK1.15030110
53ERBB31.14546453
54TRPM71.10504307
55STK31.08580767
56PTK61.07857313
57PBK1.06879460
58CDK81.06518655
59WNK11.06039022
60FRK1.04745654
61NTRK31.03980486
62MAP4K20.99685116
63LMTK20.97737959
64PAK60.97732912
65MAP3K120.97078290
66BCR0.94869512
67PRKCE0.92725612
68PIK3CG0.92389930
69ROCK20.91670880
70RET0.91654314
71PLK40.89512685
72PDK20.87651318
73TTK0.87554281
74MAPKAPK50.87146436
75ADRBK10.86967007
76ERBB40.86319791
77MAP2K10.85681852
78MST40.84575375
79BMX0.83697580
80MOS0.81735063
81EPHB10.78784552
82DMPK0.74916215
83TLK10.73737323
84BRSK10.73651143
85CHEK20.72071599
86MST1R0.71432986
87PRKG20.70629321
88MKNK10.69285009
89PHKG20.68530370
90PHKG10.68530370
91MELK0.68129859
92CSNK1G10.67751466
93PRKD10.67616709
94KSR20.67534710
95PRKCH0.65936485
96NEK60.64605065
97MAP3K40.64458127
98CSNK1A1L0.63568775
99TAF10.63160995
100STK160.62438059
101SRPK10.61168404
102CAMKK20.60349684
103INSR0.60018305
104TIE10.59956448
105CDC42BPA0.57124478
106STK380.56218202
107NEK20.56188186
108EPHA20.55082723
109MAPKAPK30.55064423
110GSK3A0.53951670
111IGF1R0.53913707
112NEK90.53501780
113PAK40.53479421
114MAPK150.52992300
115PLK10.52767997
116ERN10.52730416
117CSNK1G20.52479510
118EIF2AK20.51803812
119CAMK2A0.51492719
120PIM20.50918968
121FLT30.50536253
122MAPK130.50200832
123CASK0.49987878
124MAP3K30.49726964
125CAMK2D0.49484374
126EPHA40.49331548
127PRKD20.49291375
128TESK10.49112956
129TGFBR20.48895205
130MAPK70.48863574
131ABL20.48686093
132HIPK20.48496951
133TSSK60.47433642
134LRRK20.47032277
135MINK10.46837673
136SRC0.46678325
137STK240.46575580
138DYRK1A0.45590782
139GRK70.45042627
140CSNK1G30.44872591
141PRKAA20.44730953
142CDK140.44626552
143MTOR0.44136302
144MAPK120.42658015
145TYRO30.42584746
146MAP3K20.40728170
147PINK10.40550530
148CAMK10.40354885
149PRKCG0.34815901
150NME10.29479798

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.22918697
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.29885898
3Protein digestion and absorption_Homo sapiens_hsa049742.89413105
4Focal adhesion_Homo sapiens_hsa045102.34508301
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20507267
6Selenocompound metabolism_Homo sapiens_hsa004502.12316285
7One carbon pool by folate_Homo sapiens_hsa006702.01839884
8Homologous recombination_Homo sapiens_hsa034401.90047522
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81168120
10N-Glycan biosynthesis_Homo sapiens_hsa005101.81102944
11Basal transcription factors_Homo sapiens_hsa030221.78857896
12Hedgehog signaling pathway_Homo sapiens_hsa043401.78291059
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76018385
14Sulfur metabolism_Homo sapiens_hsa009201.75314661
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75191197
16RNA polymerase_Homo sapiens_hsa030201.73767742
17Dilated cardiomyopathy_Homo sapiens_hsa054141.73001464
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67566518
19Basal cell carcinoma_Homo sapiens_hsa052171.64662231
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.62883693
21TGF-beta signaling pathway_Homo sapiens_hsa043501.62663830
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.62057541
23Malaria_Homo sapiens_hsa051441.61108668
24Protein export_Homo sapiens_hsa030601.56312977
25Proteasome_Homo sapiens_hsa030501.53150794
26Nitrogen metabolism_Homo sapiens_hsa009101.48822095
27Proteoglycans in cancer_Homo sapiens_hsa052051.48447504
28Steroid biosynthesis_Homo sapiens_hsa001001.44243529
29Hippo signaling pathway_Homo sapiens_hsa043901.43919256
30Ovarian steroidogenesis_Homo sapiens_hsa049131.36706922
31Fanconi anemia pathway_Homo sapiens_hsa034601.34001934
32Nucleotide excision repair_Homo sapiens_hsa034201.32145469
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.30692238
34Vibrio cholerae infection_Homo sapiens_hsa051101.30562991
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29073155
36Amoebiasis_Homo sapiens_hsa051461.28582367
37Axon guidance_Homo sapiens_hsa043601.28210357
38Adherens junction_Homo sapiens_hsa045201.26986837
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25593622
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21910653
41p53 signaling pathway_Homo sapiens_hsa041151.19560252
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19450649
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16262599
44Melanogenesis_Homo sapiens_hsa049161.15344071
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14937357
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14765818
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14177543
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11445163
49Non-homologous end-joining_Homo sapiens_hsa034501.11316335
50Fatty acid metabolism_Homo sapiens_hsa012121.10450901
51Phototransduction_Homo sapiens_hsa047441.09446612
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09003264
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01625837
54Butanoate metabolism_Homo sapiens_hsa006501.00373367
55Tight junction_Homo sapiens_hsa045300.99927794
56RNA degradation_Homo sapiens_hsa030180.99070010
57Fatty acid elongation_Homo sapiens_hsa000620.97143115
58Cocaine addiction_Homo sapiens_hsa050300.97034040
59Wnt signaling pathway_Homo sapiens_hsa043100.95918027
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93868470
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93156898
62Thyroid hormone synthesis_Homo sapiens_hsa049180.92653645
63GABAergic synapse_Homo sapiens_hsa047270.91117579
64RNA transport_Homo sapiens_hsa030130.90527297
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.90039853
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.88032814
67Fatty acid degradation_Homo sapiens_hsa000710.87813897
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87328548
69MicroRNAs in cancer_Homo sapiens_hsa052060.84806550
70Tryptophan metabolism_Homo sapiens_hsa003800.84784810
71Glutathione metabolism_Homo sapiens_hsa004800.83203919
72Bladder cancer_Homo sapiens_hsa052190.82813599
73Propanoate metabolism_Homo sapiens_hsa006400.82407019
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81879299
75Starch and sucrose metabolism_Homo sapiens_hsa005000.81229147
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81005858
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.78769334
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77496269
79Vitamin B6 metabolism_Homo sapiens_hsa007500.77267532
80Melanoma_Homo sapiens_hsa052180.77167847
81PPAR signaling pathway_Homo sapiens_hsa033200.76520527
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.75741237
83Gap junction_Homo sapiens_hsa045400.75393844
84Oxidative phosphorylation_Homo sapiens_hsa001900.75029575
85Mismatch repair_Homo sapiens_hsa034300.74192030
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73319922
87Pyrimidine metabolism_Homo sapiens_hsa002400.73223625
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73159932
89Arginine and proline metabolism_Homo sapiens_hsa003300.72793999
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.71701404
91Circadian entrainment_Homo sapiens_hsa047130.68798804
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.68635228
93Complement and coagulation cascades_Homo sapiens_hsa046100.67019215
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66339943
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65880259
96Purine metabolism_Homo sapiens_hsa002300.64858078
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64407269
98Mineral absorption_Homo sapiens_hsa049780.64166661
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63938924
100Sulfur relay system_Homo sapiens_hsa041220.63688051
101Estrogen signaling pathway_Homo sapiens_hsa049150.63436969
102Fatty acid biosynthesis_Homo sapiens_hsa000610.62780101
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62081007
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61990631
105Metabolic pathways_Homo sapiens_hsa011000.61424820
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61388327
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61329248
108Glutamatergic synapse_Homo sapiens_hsa047240.61083226
109Vitamin digestion and absorption_Homo sapiens_hsa049770.60747522
110Prostate cancer_Homo sapiens_hsa052150.60481057
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.59450076
112Phagosome_Homo sapiens_hsa041450.58931711
113Insulin secretion_Homo sapiens_hsa049110.58782010
114Small cell lung cancer_Homo sapiens_hsa052220.58694875
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58243278
116Ether lipid metabolism_Homo sapiens_hsa005650.57547213
117Huntingtons disease_Homo sapiens_hsa050160.57449617
118GnRH signaling pathway_Homo sapiens_hsa049120.56971721
119Renal cell carcinoma_Homo sapiens_hsa052110.56686469
120cAMP signaling pathway_Homo sapiens_hsa040240.56408995
121Pathways in cancer_Homo sapiens_hsa052000.56100960
122Long-term depression_Homo sapiens_hsa047300.54574719
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54282495
124Peroxisome_Homo sapiens_hsa041460.53751127
125Salivary secretion_Homo sapiens_hsa049700.53743091
126Rap1 signaling pathway_Homo sapiens_hsa040150.53351888
127Cell cycle_Homo sapiens_hsa041100.53181451
128Linoleic acid metabolism_Homo sapiens_hsa005910.52440190
129Cholinergic synapse_Homo sapiens_hsa047250.51573507
130Amphetamine addiction_Homo sapiens_hsa050310.51335738
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51237740
132Parkinsons disease_Homo sapiens_hsa050120.51101809
133Chemical carcinogenesis_Homo sapiens_hsa052040.50623252
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50033914
135Retinol metabolism_Homo sapiens_hsa008300.49808386
136Bile secretion_Homo sapiens_hsa049760.49678670
137Renin secretion_Homo sapiens_hsa049240.49208957
138Ras signaling pathway_Homo sapiens_hsa040140.47551968
139Glioma_Homo sapiens_hsa052140.46139063
140Circadian rhythm_Homo sapiens_hsa047100.45862982
141Oxytocin signaling pathway_Homo sapiens_hsa049210.45765449
142Alzheimers disease_Homo sapiens_hsa050100.45421917
143Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44984435
144Sphingolipid metabolism_Homo sapiens_hsa006000.44846606
145Glucagon signaling pathway_Homo sapiens_hsa049220.44184053
146Cardiac muscle contraction_Homo sapiens_hsa042600.43844264
147Pyruvate metabolism_Homo sapiens_hsa006200.43685119
148Arginine biosynthesis_Homo sapiens_hsa002200.43084863
149Lysine degradation_Homo sapiens_hsa003100.42792278
150Dorso-ventral axis formation_Homo sapiens_hsa043200.41665738
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40582094
152Dopaminergic synapse_Homo sapiens_hsa047280.40194397

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