FKBP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)5.53464727
2modulation by symbiont of host defense response (GO:0052031)5.47079034
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.47079034
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.47079034
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.47079034
6modulation by symbiont of host immune response (GO:0052553)5.47079034
7positive regulation by symbiont of host defense response (GO:0052509)5.47079034
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.92440262
9positive regulation of gamma-delta T cell activation (GO:0046645)4.84221258
10detection of other organism (GO:0098543)4.62217807
11macrophage activation involved in immune response (GO:0002281)4.46891530
12detection of external biotic stimulus (GO:0098581)4.27041688
13positive regulation of interferon-alpha production (GO:0032727)4.26414859
14detection of bacterium (GO:0016045)4.23419993
15regulation of B cell receptor signaling pathway (GO:0050855)4.18140494
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10328929
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10328929
18antigen processing and presentation of endogenous antigen (GO:0019883)4.07734634
19regulation of interferon-alpha production (GO:0032647)4.03091742
20negative regulation of cell killing (GO:0031342)3.92620408
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92620408
22positive regulation of B cell differentiation (GO:0045579)3.88675111
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.82384452
24detection of biotic stimulus (GO:0009595)3.73596717
25response to host immune response (GO:0052572)3.62699320
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.62699320
27neutrophil activation involved in immune response (GO:0002283)3.54304224
28regulation of interleukin-12 biosynthetic process (GO:0045075)3.49785499
29regulation of gamma-delta T cell differentiation (GO:0045586)3.48786312
30regulation of gamma-delta T cell activation (GO:0046643)3.45589274
31negative regulation of erythrocyte differentiation (GO:0045647)3.44382921
32B cell receptor signaling pathway (GO:0050853)3.44329066
33regulation of myeloid leukocyte mediated immunity (GO:0002886)3.40203471
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.38690460
35response to host (GO:0075136)3.38690460
36response to host defenses (GO:0052200)3.38690460
37microglial cell activation (GO:0001774)3.35354394
38immunoglobulin mediated immune response (GO:0016064)3.32647580
39production of molecular mediator involved in inflammatory response (GO:0002532)3.32450771
40regulation of B cell differentiation (GO:0045577)3.30750179
41negative regulation of granulocyte differentiation (GO:0030853)3.29371297
42positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24694943
43positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.24537463
44positive regulation of antigen processing and presentation (GO:0002579)3.24282675
45positive regulation of mast cell degranulation (GO:0043306)3.19272726
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.19272726
47glycosphingolipid catabolic process (GO:0046479)3.18820314
48positive regulation of interferon-beta production (GO:0032728)3.17883951
49response to peptidoglycan (GO:0032494)3.17820297
50positive regulation of cellular amide metabolic process (GO:0034250)3.16386402
51I-kappaB phosphorylation (GO:0007252)3.15835476
52mannose metabolic process (GO:0006013)3.12507467
53cellular response to thyroid hormone stimulus (GO:0097067)3.08646477
54positive regulation of leukocyte degranulation (GO:0043302)3.07528864
55amino sugar catabolic process (GO:0046348)3.07209564
56myeloid cell activation involved in immune response (GO:0002275)3.05030085
57pinocytosis (GO:0006907)3.04672984
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.04335558
59positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.02078987
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.00317118
61respiratory burst (GO:0045730)3.00034385
62neutrophil activation (GO:0042119)2.98481346
63macrophage activation (GO:0042116)2.98189177
64negative regulation of interleukin-12 production (GO:0032695)2.97909449
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97049725
66response to muramyl dipeptide (GO:0032495)2.96040150
67positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.93961002
68negative regulation of T cell mediated immunity (GO:0002710)2.89634257
69protein localization to endosome (GO:0036010)2.88775426
70negative regulation of leukocyte mediated immunity (GO:0002704)2.86107434
71apoptotic cell clearance (GO:0043277)2.84819671
72regulation of macrophage cytokine production (GO:0010935)2.84805115
73glycolipid catabolic process (GO:0019377)2.84448172
74granulocyte activation (GO:0036230)2.83877121
75T-helper 1 type immune response (GO:0042088)2.82879313
76regulation of tolerance induction (GO:0002643)2.81597242
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80941526
78positive regulation of macrophage cytokine production (GO:0060907)2.80494114
79response to type I interferon (GO:0034340)2.78396125
80regulation of T cell tolerance induction (GO:0002664)2.78272171
81oligosaccharide catabolic process (GO:0009313)2.78077020
82positive thymic T cell selection (GO:0045059)2.77502374
83positive regulation of natural killer cell differentiation (GO:0032825)2.77326684
84regulation of cholesterol storage (GO:0010885)2.77226305
85interferon-gamma-mediated signaling pathway (GO:0060333)2.76184258
86regulation of regulated secretory pathway (GO:1903305)2.75990534
87B cell mediated immunity (GO:0019724)2.75826384
88JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.75061296
89negative regulation of interleukin-17 production (GO:0032700)2.71998089
90cellular extravasation (GO:0045123)2.71868838
91regulation of antigen processing and presentation (GO:0002577)2.71553354
92type I interferon signaling pathway (GO:0060337)2.71544048
93cellular response to type I interferon (GO:0071357)2.71544048
94germinal center formation (GO:0002467)2.68656044
95regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.66013836
96NIK/NF-kappaB signaling (GO:0038061)2.64935921
97positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.64260055
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.63187485
99neutrophil mediated immunity (GO:0002446)2.61428910
100lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61241534
101regulation of T-helper 2 cell differentiation (GO:0045628)2.59933967
102B cell homeostasis (GO:0001782)2.57474877
103regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.55965535
104regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55949493
105regulation of integrin activation (GO:0033623)2.54333142
106positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.54121453
107negative thymic T cell selection (GO:0045060)2.53951246
108leukocyte aggregation (GO:0070486)2.51901266
109regulation of dendritic cell antigen processing and presentation (GO:0002604)2.51007809
110regulation of interferon-beta production (GO:0032648)2.50824668
111cellular response to exogenous dsRNA (GO:0071360)2.50551335
112regulation of phagocytosis (GO:0050764)2.50404563
113detection of molecule of bacterial origin (GO:0032490)2.50401870
114negative regulation of lipid storage (GO:0010888)2.48219527
115response to laminar fluid shear stress (GO:0034616)2.48180437
116leukocyte cell-cell adhesion (GO:0007159)2.48084324
117regulation of mast cell activation (GO:0033003)2.47580450
118antigen processing and presentation via MHC class Ib (GO:0002475)2.47482546
119regulation of mast cell degranulation (GO:0043304)2.46985628
120negative T cell selection (GO:0043383)2.45715315
121mature B cell differentiation (GO:0002335)2.43193823
122defense response to protozoan (GO:0042832)2.42239505
123positive regulation of phagocytosis (GO:0050766)2.41386615
124phospholipid homeostasis (GO:0055091)2.40602514
125negative regulation of bone resorption (GO:0045779)2.38867928
126regulation of mast cell activation involved in immune response (GO:0033006)2.37745716
127natural killer cell mediated cytotoxicity (GO:0042267)2.36917267
128natural killer cell mediated immunity (GO:0002228)2.36917267
129positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.36722418
130myeloid leukocyte activation (GO:0002274)2.36039125
131tolerance induction (GO:0002507)2.35715904
132negative regulation of interleukin-6 production (GO:0032715)2.35295411
133negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.32693809
134positive regulation of mast cell activation (GO:0033005)2.30271684
135regulation of leukocyte degranulation (GO:0043300)2.28856475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.91853073
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.41054094
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.73970686
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.69034781
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60223647
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.58883198
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.51735299
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25898979
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15167689
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.03293090
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98653956
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76904573
13SCL_19346495_ChIP-Seq_HPC-7_Human2.75499731
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.73041167
15GATA1_22025678_ChIP-Seq_K562_Human2.70802477
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.70740076
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61255625
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.35336429
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34911042
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.33428833
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33212972
22VDR_21846776_ChIP-Seq_THP-1_Human2.31474682
23RUNX_20019798_ChIP-Seq_JUKART_Human2.28496131
24MYC_22102868_ChIP-Seq_BL_Human2.28048490
25* SPI1_23127762_ChIP-Seq_K562_Human2.19414259
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19142348
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17816468
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98609490
29* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96793036
30VDR_24763502_ChIP-Seq_THP-1_Human1.96432252
31MAF_26560356_Chip-Seq_TH1_Human1.95910907
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.93288485
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93284445
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.90352302
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89333423
36MYB_26560356_Chip-Seq_TH2_Human1.88797545
37TCF7_22412390_ChIP-Seq_EML_Mouse1.87696936
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87589321
39SPI1_23547873_ChIP-Seq_NB4_Human1.87541394
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87214517
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.83193338
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.81708552
43MYB_26560356_Chip-Seq_TH1_Human1.75224466
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.72638154
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70657217
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69207120
47UTX_26944678_Chip-Seq_JUKART_Human1.62909350
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56392664
49PU_27001747_Chip-Seq_BMDM_Mouse1.54342609
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.54305764
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53093452
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.46969273
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46110143
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44786445
55VDR_24787735_ChIP-Seq_THP-1_Human1.44503892
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36696444
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35635112
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35344281
59GATA3_27048872_Chip-Seq_THYMUS_Human1.33677370
60KDM2B_26808549_Chip-Seq_DND41_Human1.33514165
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.33409624
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31872616
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31206291
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30059964
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26029464
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25742383
67GATA1_19941826_ChIP-Seq_K562_Human1.23601406
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22249479
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20822645
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20333684
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20068032
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19809329
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18009034
74GATA2_19941826_ChIP-Seq_K562_Human1.17442634
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14728275
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11308150
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10990559
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.10239139
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.09812957
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09480483
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07806216
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.06283719
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06096157
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04320192
85MAF_26560356_Chip-Seq_TH2_Human1.03169997
86* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01115355
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99909838
88TFEB_21752829_ChIP-Seq_HELA_Human0.99806081
89GATA3_26560356_Chip-Seq_TH2_Human0.98470715
90LXR_22292898_ChIP-Seq_THP-1_Human0.95575503
91CLOCK_20551151_ChIP-Seq_293T_Human0.95364373
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95321486
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93995127
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93828868
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93781124
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93096482
97KDM2B_26808549_Chip-Seq_K562_Human0.91998717
98FOXA2_19822575_ChIP-Seq_HepG2_Human0.91594700
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91058520
100NCOR1_26117541_ChIP-Seq_K562_Human0.90697779
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90277081
102RACK7_27058665_Chip-Seq_MCF-7_Human0.89496463
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89406214
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88768279
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87693011
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87080162
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85560352
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84383631
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84296703
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83865055
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83717207
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83250036
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82983005
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79981636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.65435707
2MP0001835_abnormal_antigen_presentation3.64225053
3MP0005058_abnormal_lysosome_morphology3.19923537
4MP0003436_decreased_susceptibility_to2.90775915
5MP0003303_peritoneal_inflammation2.71151686
6MP0002419_abnormal_innate_immunity2.58467551
7MP0005464_abnormal_platelet_physiology2.54184758
8MP0001800_abnormal_humoral_immune2.54094871
9MP0003300_gastrointestinal_ulcer2.51134028
10MP0003172_abnormal_lysosome_physiology2.49145942
11MP0005000_abnormal_immune_tolerance2.47905094
12MP0001790_abnormal_immune_system2.46654514
13MP0005387_immune_system_phenotype2.46654514
14MP0003191_abnormal_cellular_cholesterol2.42791580
15MP0000685_abnormal_immune_system2.39276905
16MP0002452_abnormal_antigen_presenting2.37774365
17MP0008260_abnormal_autophagy2.33303579
18MP0005671_abnormal_response_to2.31408157
19MP0005025_abnormal_response_to2.27514198
20MP0002723_abnormal_immune_serum2.17518133
21MP0006082_CNS_inflammation2.16578585
22MP0009785_altered_susceptibility_to2.09329717
23MP0009840_abnormal_foam_cell2.05155685
24MP0005451_abnormal_body_composition2.01588402
25MP0002420_abnormal_adaptive_immunity2.00808968
26MP0003828_pulmonary_edema2.00761078
27MP0001819_abnormal_immune_cell2.00518014
28MP0004947_skin_inflammation1.88927902
29MP0002148_abnormal_hypersensitivity_rea1.88819670
30MP0004510_myositis1.86319470
31MP0002166_altered_tumor_susceptibility1.83255132
32MP0002405_respiratory_system_inflammati1.65851491
33MP0001845_abnormal_inflammatory_respons1.65824361
34MP0002398_abnormal_bone_marrow1.64373882
35MP0002396_abnormal_hematopoietic_system1.60079711
36MP0000716_abnormal_immune_system1.59621294
37MP0000689_abnormal_spleen_morphology1.55279170
38MP0009278_abnormal_bone_marrow1.54503224
39MP0001533_abnormal_skeleton_physiology1.53591830
40MP0002006_tumorigenesis1.51369180
41MP0003183_abnormal_peptide_metabolism1.49255724
42MP0005360_urolithiasis1.47241711
43MP0008469_abnormal_protein_level1.46315024
44MP0010155_abnormal_intestine_physiology1.44926557
45MP0002877_abnormal_melanocyte_morpholog1.44111733
46MP0003724_increased_susceptibility_to1.43567066
47MP0003566_abnormal_cell_adhesion1.42321640
48MP0002138_abnormal_hepatobiliary_system1.41869939
49MP0001873_stomach_inflammation1.39588945
50MP0004883_abnormal_blood_vessel1.38610655
51MP0004381_abnormal_hair_follicle1.36149207
52MP0002722_abnormal_immune_system1.35892208
53MP0002429_abnormal_blood_cell1.34727145
54MP0005174_abnormal_tail_pigmentation1.30136654
55MP0005310_abnormal_salivary_gland1.29864262
56MP0001853_heart_inflammation1.29813690
57MP0003763_abnormal_thymus_physiology1.26941725
58MP0002139_abnormal_hepatobiliary_system1.25471599
59MP0000604_amyloidosis1.24501947
60MP0005365_abnormal_bile_salt1.23751273
61MP0000465_gastrointestinal_hemorrhage1.23309452
62MP0003690_abnormal_glial_cell1.21923150
63MP0003705_abnormal_hypodermis_morpholog1.21635383
64MP0003252_abnormal_bile_duct1.21144658
65MP0005164_abnormal_response_to1.20882151
66MP0009333_abnormal_splenocyte_physiolog1.20593155
67MP0003453_abnormal_keratinocyte_physiol1.17902769
68MP0004808_abnormal_hematopoietic_stem1.17829310
69MP0003329_amyloid_beta_deposits1.15502172
70MP0003448_altered_tumor_morphology1.15465927
71MP0000371_diluted_coat_color1.13936610
72MP0000609_abnormal_liver_physiology1.13804509
73MP0000015_abnormal_ear_pigmentation1.12343420
74MP0009764_decreased_sensitivity_to1.12317946
75MP0002998_abnormal_bone_remodeling1.11557214
76MP0003075_altered_response_to1.11077095
77MP0003656_abnormal_erythrocyte_physiolo1.09740024
78MP0002933_joint_inflammation1.07845256
79MP0001958_emphysema1.06163876
80MP0002254_reproductive_system_inflammat1.05383237
81MP0009763_increased_sensitivity_to1.03803827
82MP0008438_abnormal_cutaneous_collagen1.02037669
83MP0005076_abnormal_cell_differentiation1.01903556
84MP0005397_hematopoietic_system_phenotyp1.01267190
85MP0001545_abnormal_hematopoietic_system1.01267190
86MP0000343_altered_response_to1.01228545
87MP0003045_fibrosis0.99945431
88MP0003091_abnormal_cell_migration0.98833599
89MP0001851_eye_inflammation0.97460183
90MP0010307_abnormal_tumor_latency0.95568726
91MP0010329_abnormal_lipoprotein_level0.94359326
92MP0004130_abnormal_muscle_cell0.91204824
93MP0000858_altered_metastatic_potential0.90960348
94MP0010234_abnormal_vibrissa_follicle0.90131375
95MP0000703_abnormal_thymus_morphology0.89225296
96MP0006054_spinal_hemorrhage0.89068261
97MP0000920_abnormal_myelination0.88249941
98MP0002136_abnormal_kidney_physiology0.88015098
99MP0000249_abnormal_blood_vessel0.87689772
100MP0003866_abnormal_defecation0.86253527
101MP0005166_decreased_susceptibility_to0.85744860
102MP0003279_aneurysm0.85366471
103MP0003795_abnormal_bone_structure0.84357634
104MP0005023_abnormal_wound_healing0.81610584
105MP0005390_skeleton_phenotype0.81417469
106MP0002132_abnormal_respiratory_system0.81099750
107MP0005670_abnormal_white_adipose0.80705789
108MP0001915_intracranial_hemorrhage0.80479975
109MP0008004_abnormal_stomach_pH0.78325675
110MP0000598_abnormal_liver_morphology0.77558552
111MP0005083_abnormal_biliary_tract0.76524523
112MP0002928_abnormal_bile_duct0.75668108
113MP0009643_abnormal_urine_homeostasis0.72530568
114MP0000767_abnormal_smooth_muscle0.71793796
115MP0005666_abnormal_adipose_tissue0.71751423
116MP0010352_gastrointestinal_tract_polyps0.71617488
117MP0005085_abnormal_gallbladder_physiolo0.71369485
118MP0004185_abnormal_adipocyte_glucose0.70907955
119MP0001849_ear_inflammation0.67795476
120MP0003806_abnormal_nucleotide_metabolis0.64904547
121MP0005409_darkened_coat_color0.63716555
122MP0009765_abnormal_xenobiotic_induced0.61261490
123MP0002133_abnormal_respiratory_system0.57080429
124MP0005388_respiratory_system_phenotype0.57080429

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.03958211
2Recurrent bacterial skin infections (HP:0005406)4.89532739
3Eczematoid dermatitis (HP:0000976)4.40540694
4Recurrent gram-negative bacterial infections (HP:0005420)4.32968843
5Systemic lupus erythematosus (HP:0002725)4.16878560
6Recurrent viral infections (HP:0004429)3.63435764
7Recurrent fungal infections (HP:0002841)3.53761445
8Dysostosis multiplex (HP:0000943)3.41735523
9Increased cerebral lipofuscin (HP:0011813)3.41120443
10Recurrent skin infections (HP:0001581)3.28550483
11Glomerulonephritis (HP:0000099)3.24272319
12Periodontitis (HP:0000704)3.24236242
13Colitis (HP:0002583)3.22520279
14Cellulitis (HP:0100658)3.18867240
15Abnormality of macrophages (HP:0004311)3.16476656
16Myocardial infarction (HP:0001658)3.15855300
17Myositis (HP:0100614)3.09689506
18Vacuolated lymphocytes (HP:0001922)3.07848804
19Urinary glycosaminoglycan excretion (HP:0003541)3.01768399
20Mucopolysacchariduria (HP:0008155)3.01768399
21Abnormality of polysaccharide metabolism (HP:0011012)3.01639210
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.01639210
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.01639210
24Gingivitis (HP:0000230)3.01154595
25Elevated erythrocyte sedimentation rate (HP:0003565)3.00004617
26Complement deficiency (HP:0004431)2.94944653
27Autoimmune thrombocytopenia (HP:0001973)2.90579508
28Increased neuronal autofluorescent lipopigment (HP:0002074)2.87607278
29Pustule (HP:0200039)2.84426045
30Inflammation of the large intestine (HP:0002037)2.76320477
31Abnormality of liposaccharide metabolism (HP:0010968)2.74408119
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.74408119
33Abnormality of glycolipid metabolism (HP:0010969)2.74408119
34Abnormality of complement system (HP:0005339)2.68685752
35Gingival bleeding (HP:0000225)2.67982813
36Gastrointestinal inflammation (HP:0004386)2.67845400
37Hematochezia (HP:0002573)2.65787228
38Gastrointestinal infarctions (HP:0005244)2.63524678
39Mediastinal lymphadenopathy (HP:0100721)2.62848669
40Amyloidosis (HP:0011034)2.57155253
41Agammaglobulinemia (HP:0004432)2.55058850
42Spontaneous hematomas (HP:0007420)2.52520419
43Loss of speech (HP:0002371)2.51939135
44Vasculitis (HP:0002633)2.51804727
45Chronic mucocutaneous candidiasis (HP:0002728)2.51326350
46Recurrent cutaneous fungal infections (HP:0011370)2.51326350
47Orchitis (HP:0100796)2.50677103
48Interstitial pulmonary disease (HP:0006530)2.49709527
49Chronic otitis media (HP:0000389)2.49013061
50Keratoconjunctivitis sicca (HP:0001097)2.47093748
51Cerebral aneurysm (HP:0004944)2.45429911
52Nephritis (HP:0000123)2.44192752
53Osteomyelitis (HP:0002754)2.43833841
54Arterial thrombosis (HP:0004420)2.40775773
55Abnormality of the fingertips (HP:0001211)2.39342644
56Meningitis (HP:0001287)2.38128954
57Hemoptysis (HP:0002105)2.36450543
58Neuronal loss in central nervous system (HP:0002529)2.36053112
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.34286430
60Purpura (HP:0000979)2.32874325
61Prolonged bleeding time (HP:0003010)2.32551249
62Joint hemorrhage (HP:0005261)2.31807337
63Axonal loss (HP:0003447)2.30770082
64Upper motor neuron abnormality (HP:0002127)2.30394725
65Mutism (HP:0002300)2.28614290
66Neurofibrillary tangles (HP:0002185)2.28237348
67Chest pain (HP:0100749)2.26681606
68Leukocytosis (HP:0001974)2.23224499
69Abnormal platelet function (HP:0011869)2.21356949
70Impaired platelet aggregation (HP:0003540)2.21356949
71Epistaxis (HP:0000421)2.21233208
72Mitral stenosis (HP:0001718)2.19324785
73Keratoconjunctivitis (HP:0001096)2.18468905
74Obstructive lung disease (HP:0006536)2.17762784
75Chronic obstructive pulmonary disease (HP:0006510)2.17762784
76Retrobulbar optic neuritis (HP:0100654)2.17233049
77Optic neuritis (HP:0100653)2.17233049
78IgM deficiency (HP:0002850)2.15278303
79Global brain atrophy (HP:0002283)2.12499044
80Thoracic kyphosis (HP:0002942)2.12120498
81Hepatosplenomegaly (HP:0001433)2.09907145
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.08293620
83Osteolytic defects of the hand bones (HP:0009699)2.08293620
84Increased serum ferritin (HP:0003281)2.07976699
85Encephalitis (HP:0002383)2.07781376
86Apathy (HP:0000741)2.06602096
87T lymphocytopenia (HP:0005403)2.04801636
88Diminished motivation (HP:0000745)2.04661523
89Urticaria (HP:0001025)2.03795478
90Pathologic fracture (HP:0002756)2.01530578
91Recurrent bronchitis (HP:0002837)2.01004696
92Thyroiditis (HP:0100646)2.00989719
93Panhypogammaglobulinemia (HP:0003139)2.00808448
94Asymmetric septal hypertrophy (HP:0001670)2.00661302
95Abnormality of T cell number (HP:0011839)2.00328169
96Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00167023
97Spondylolisthesis (HP:0003302)1.99138502
98Malnutrition (HP:0004395)1.98953798
99Peritonitis (HP:0002586)1.98733047
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98241622
101Premature loss of primary teeth (HP:0006323)1.96122653
102Abnormal platelet volume (HP:0011876)1.96000297
103Menorrhagia (HP:0000132)1.94450189
104Disinhibition (HP:0000734)1.94254213
105Gastrointestinal stroma tumor (HP:0100723)1.93282826
106Chronic diarrhea (HP:0002028)1.92870229
107Petechiae (HP:0000967)1.92335942
108Deep venous thrombosis (HP:0002625)1.91904380
109Cerebral inclusion bodies (HP:0100314)1.90272560
110Pulmonary infiltrates (HP:0002113)1.90270258
111Prostate neoplasm (HP:0100787)1.90121039
112Thick nail (HP:0001805)1.89415971
113Absent frontal sinuses (HP:0002688)1.89189934
114Abnormality of the thoracic spine (HP:0100711)1.86510216
115Emphysema (HP:0002097)1.86478715
116Lymphopenia (HP:0001888)1.86342349
117Slow saccadic eye movements (HP:0000514)1.85888652
118Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85221822
119Aortic aneurysm (HP:0004942)1.84845866
120Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84828889
121Progressive neurologic deterioration (HP:0002344)1.81860108
122Pulmonary embolism (HP:0002204)1.81816288
123Stomatitis (HP:0010280)1.81404775
124Eosinophilia (HP:0001880)1.81073081
125Restrictive lung disease (HP:0002091)1.80775381
126Sepsis (HP:0100806)1.80558053
127Increased IgE level (HP:0003212)1.80252181
128Albinism (HP:0001022)1.79327442
129Abnormality of iron homeostasis (HP:0011031)1.76477105
130Abnormality of the peritoneum (HP:0002585)1.75254409
131Vertebral compression fractures (HP:0002953)1.75220216
132Segmental peripheral demyelination/remyelination (HP:0003481)1.73701837
133Hypergammaglobulinemia (HP:0010702)1.73417953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.85232522
2BLK3.19257801
3TYK23.05229268
4ERN12.65199843
5PRPF4B2.58762852
6MAP3K142.55813292
7JAK12.33054316
8TGFBR22.25389951
9IRAK42.24938853
10RIPK42.23569129
11TAOK32.18068160
12TBK12.17915273
13KIT2.17380767
14CSF1R2.06099743
15TRIB32.05527736
16JAK32.04621948
17CAMK1D2.00172751
18IRAK31.94718716
19CDK121.90025032
20ZAP701.82284712
21FGFR41.77478759
22MAP3K131.75765106
23CSK1.71708607
24STK101.63519123
25IKBKE1.62428162
26MAP3K101.59557755
27EPHB11.59400949
28MAP3K31.58726382
29SYK1.52857046
30TXK1.52196252
31ITK1.46219509
32HCK1.42276445
33IKBKB1.42192575
34CAMK1G1.41358862
35PTK61.34124678
36KSR21.32925336
37TTN1.32812631
38BTK1.29512399
39TEC1.27775729
40PKN21.27436218
41SIK11.25569926
42TAOK11.23549326
43FGFR31.19929578
44CDC42BPA1.19142216
45GRK61.17416082
46CHUK1.15106206
47LCK1.14902151
48GRK71.14603335
49EEF2K1.11581418
50JAK21.11198035
51MAP3K11.11020366
52FES1.09564501
53TNK21.09319360
54MARK21.07968892
55MAP2K31.06750957
56RIPK11.06654570
57LYN1.05206879
58MATK1.05174889
59CLK11.02468351
60MOS0.98029215
61SIK30.95453074
62SCYL20.93171985
63SIK20.92332300
64RPS6KA40.92088138
65TRPM70.90257845
66LRRK20.89882226
67MAP3K20.89805579
68TAOK20.87702153
69PDK20.85168282
70MAP3K110.83542457
71NEK90.83432546
72CAMKK20.82264248
73BMPR20.80210715
74PIM10.78637515
75MARK30.77447499
76SGK30.76462523
77PDGFRB0.68073380
78CDK60.67631472
79STK40.67536268
80FLT30.67406382
81IRAK20.66499639
82INSRR0.66425238
83CAMKK10.66175632
84RAF10.65938735
85KSR10.64724135
86PRKD20.64145883
87FGR0.63631727
88PDK10.63448881
89BRD40.60843740
90IRAK10.59715143
91EGFR0.59379469
92PRKCH0.58650221
93RPS6KA20.57745064
94NUAK10.57436486
95MAP3K70.56662482
96ICK0.55137273
97PRKCQ0.54484988
98RPS6KC10.54138585
99RPS6KL10.54138585
100DDR20.53233760
101PDPK10.52277396
102HIPK20.51634589
103EPHA30.51037020
104TESK20.50862940
105ARAF0.50646512
106MAPK110.50631217
107PRKAA20.50139380
108TIE10.46741114
109ABL10.45957958
110MTOR0.45194038
111SMG10.45145708
112FYN0.45120435
113IGF1R0.44583578
114BMX0.44504255
115RET0.44105602
116STK30.42681698
117MAP3K50.42644636
118MAPK120.41582644
119NEK60.38514823
120PIK3CG0.37089437
121CAMK40.36969462
122MAPKAPK20.35848145
123DMPK0.34362411
124MAPK70.34204692
125MELK0.34195837
126PAK40.34005833
127MAP3K60.33067717
128CDK90.32491929
129NLK0.32000333
130PRKCD0.31787549
131MAP3K80.31710314
132RPS6KA60.31649072
133YES10.30861730
134INSR0.30192787

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.58050047
2Leishmaniasis_Homo sapiens_hsa051402.66786460
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.53554180
4B cell receptor signaling pathway_Homo sapiens_hsa046622.43958047
5Osteoclast differentiation_Homo sapiens_hsa043802.41301410
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.17942529
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09172229
8Lysosome_Homo sapiens_hsa041422.05532755
9Measles_Homo sapiens_hsa051621.89504991
10Primary immunodeficiency_Homo sapiens_hsa053401.86738117
11Pertussis_Homo sapiens_hsa051331.84935935
12Complement and coagulation cascades_Homo sapiens_hsa046101.81687706
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78757467
14Autoimmune thyroid disease_Homo sapiens_hsa053201.74502884
15Other glycan degradation_Homo sapiens_hsa005111.72384476
16Caffeine metabolism_Homo sapiens_hsa002321.70513725
17Tuberculosis_Homo sapiens_hsa051521.69944860
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58446585
19Hematopoietic cell lineage_Homo sapiens_hsa046401.56731965
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56080339
21Legionellosis_Homo sapiens_hsa051341.54429892
22Antigen processing and presentation_Homo sapiens_hsa046121.49543542
23Toxoplasmosis_Homo sapiens_hsa051451.47115965
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46845694
25Influenza A_Homo sapiens_hsa051641.46422831
26Asthma_Homo sapiens_hsa053101.45841842
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.45653661
28ABC transporters_Homo sapiens_hsa020101.42137763
29Malaria_Homo sapiens_hsa051441.37152229
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35955137
31Type I diabetes mellitus_Homo sapiens_hsa049401.35470606
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32305203
33Apoptosis_Homo sapiens_hsa042101.24038413
34Chemokine signaling pathway_Homo sapiens_hsa040621.22500069
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18887669
36Lysine degradation_Homo sapiens_hsa003101.18627640
37Chronic myeloid leukemia_Homo sapiens_hsa052201.18437033
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.17811955
39Graft-versus-host disease_Homo sapiens_hsa053321.12449910
40TNF signaling pathway_Homo sapiens_hsa046681.12262167
41Herpes simplex infection_Homo sapiens_hsa051681.11280956
42Hepatitis B_Homo sapiens_hsa051611.07978070
43T cell receptor signaling pathway_Homo sapiens_hsa046601.07061199
44Acute myeloid leukemia_Homo sapiens_hsa052211.06753347
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.06582155
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01267168
47Salmonella infection_Homo sapiens_hsa051321.00812125
48Platelet activation_Homo sapiens_hsa046111.00679845
49Shigellosis_Homo sapiens_hsa051310.98872623
50Hepatitis C_Homo sapiens_hsa051600.97662244
51Pancreatic cancer_Homo sapiens_hsa052120.97414531
52Renal cell carcinoma_Homo sapiens_hsa052110.96566784
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.95225420
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92683234
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89403838
56Nitrogen metabolism_Homo sapiens_hsa009100.89373169
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89287739
58Insulin resistance_Homo sapiens_hsa049310.89078262
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87827889
60Phagosome_Homo sapiens_hsa041450.87755558
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.84293725
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.82892380
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82618067
64Small cell lung cancer_Homo sapiens_hsa052220.79410964
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79330677
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78546405
67PPAR signaling pathway_Homo sapiens_hsa033200.76834751
68Amoebiasis_Homo sapiens_hsa051460.76802692
69Viral myocarditis_Homo sapiens_hsa054160.76184067
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75803968
71Allograft rejection_Homo sapiens_hsa053300.75003849
72GnRH signaling pathway_Homo sapiens_hsa049120.74244122
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71828513
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68911136
75HIF-1 signaling pathway_Homo sapiens_hsa040660.67732348
76Bladder cancer_Homo sapiens_hsa052190.67577137
77Endometrial cancer_Homo sapiens_hsa052130.67002823
78Fatty acid degradation_Homo sapiens_hsa000710.64843790
79Rheumatoid arthritis_Homo sapiens_hsa053230.64572786
80Dorso-ventral axis formation_Homo sapiens_hsa043200.63429521
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62803472
82Type II diabetes mellitus_Homo sapiens_hsa049300.61932546
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61317415
84Notch signaling pathway_Homo sapiens_hsa043300.61112163
85Non-small cell lung cancer_Homo sapiens_hsa052230.60657695
86Prolactin signaling pathway_Homo sapiens_hsa049170.59917510
87Arginine biosynthesis_Homo sapiens_hsa002200.59043927
88FoxO signaling pathway_Homo sapiens_hsa040680.57687617
89Tryptophan metabolism_Homo sapiens_hsa003800.56144218
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55120389
91Galactose metabolism_Homo sapiens_hsa000520.54526909
92Epstein-Barr virus infection_Homo sapiens_hsa051690.54013647
93Collecting duct acid secretion_Homo sapiens_hsa049660.53951699
94Estrogen signaling pathway_Homo sapiens_hsa049150.52679604
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52020151
96Prion diseases_Homo sapiens_hsa050200.51673483
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51583578
98Choline metabolism in cancer_Homo sapiens_hsa052310.51346593
99ErbB signaling pathway_Homo sapiens_hsa040120.49600558
100Endocytosis_Homo sapiens_hsa041440.48408074
101HTLV-I infection_Homo sapiens_hsa051660.47992051
102Inositol phosphate metabolism_Homo sapiens_hsa005620.47766538
103African trypanosomiasis_Homo sapiens_hsa051430.46496218
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45075461
105Prostate cancer_Homo sapiens_hsa052150.44918299
106Starch and sucrose metabolism_Homo sapiens_hsa005000.44459299
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43613793
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43349781
109Sphingolipid metabolism_Homo sapiens_hsa006000.42547816
110Viral carcinogenesis_Homo sapiens_hsa052030.40786885
111VEGF signaling pathway_Homo sapiens_hsa043700.40397953
112Bile secretion_Homo sapiens_hsa049760.39278304
113Proteoglycans in cancer_Homo sapiens_hsa052050.39193768
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.37967126
115Selenocompound metabolism_Homo sapiens_hsa004500.36606916
116mTOR signaling pathway_Homo sapiens_hsa041500.36185877
117Focal adhesion_Homo sapiens_hsa045100.35245402
118Peroxisome_Homo sapiens_hsa041460.35044479
119Adherens junction_Homo sapiens_hsa045200.34817754
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32291921
121MicroRNAs in cancer_Homo sapiens_hsa052060.31906752
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.31195459

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