FKBP1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.54858631
2Golgi transport vesicle coating (GO:0048200)5.65109346
3COPI coating of Golgi vesicle (GO:0048205)5.65109346
4pyrimidine nucleobase catabolic process (GO:0006208)5.28191396
5* protein maturation by protein folding (GO:0022417)4.68448433
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52668417
7regulation of synaptic vesicle exocytosis (GO:2000300)4.41108794
8nucleobase catabolic process (GO:0046113)4.32894921
9regulation of type B pancreatic cell apoptotic process (GO:2000674)4.28892374
10synaptic vesicle exocytosis (GO:0016079)4.28312942
11detection of calcium ion (GO:0005513)4.28162474
12regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.21777396
13synaptic vesicle maturation (GO:0016188)4.01424622
14negative regulation of norepinephrine secretion (GO:0010700)3.92976128
15peptide hormone processing (GO:0016486)3.92942614
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.91136078
17regulation of synaptic vesicle transport (GO:1902803)3.88539001
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.86919814
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.83891555
20signal peptide processing (GO:0006465)3.80119403
21postsynaptic membrane organization (GO:0001941)3.75804193
22establishment of mitochondrion localization (GO:0051654)3.72178787
23regulation of oxidative phosphorylation (GO:0002082)3.70669208
24chaperone-mediated protein transport (GO:0072321)3.70577220
25endocrine pancreas development (GO:0031018)3.64692919
26glutamate secretion (GO:0014047)3.61936097
27energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.59393753
28ATP hydrolysis coupled proton transport (GO:0015991)3.59393753
29* insulin secretion (GO:0030073)3.58860451
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.57964238
31glycerophospholipid catabolic process (GO:0046475)3.54278040
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52986512
33ER overload response (GO:0006983)3.51185534
34negative regulation of dendrite morphogenesis (GO:0050774)3.47073415
35presynaptic membrane organization (GO:0097090)3.46184338
36neurofilament cytoskeleton organization (GO:0060052)3.45716298
37negative regulation of appetite (GO:0032099)3.45576523
38negative regulation of response to food (GO:0032096)3.45576523
39regulation of amyloid precursor protein catabolic process (GO:1902991)3.44971353
40substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.44692183
41substrate-independent telencephalic tangential migration (GO:0021826)3.44692183
42detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.44205162
43detection of temperature stimulus involved in sensory perception (GO:0050961)3.44205162
44neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.43846514
45tachykinin receptor signaling pathway (GO:0007217)3.43104572
46short-term memory (GO:0007614)3.40376219
47behavioral response to cocaine (GO:0048148)3.40312445
48transferrin transport (GO:0033572)3.38570160
49behavioral response to nicotine (GO:0035095)3.32373929
50innervation (GO:0060384)3.31962307
51* regulation of insulin secretion (GO:0050796)3.29747013
52negative regulation of catecholamine secretion (GO:0033604)3.26811609
53protein retention in ER lumen (GO:0006621)3.24101746
54presynaptic membrane assembly (GO:0097105)3.23420656
55cell migration in hindbrain (GO:0021535)3.22258962
56positive regulation of neurotransmitter transport (GO:0051590)3.21093397
57negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.20444396
58neuron recognition (GO:0008038)3.19569035
59detection of temperature stimulus (GO:0016048)3.18893009
60regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.18329358
61regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.18329358
62neuron cell-cell adhesion (GO:0007158)3.16778382
63positive regulation of exocytosis (GO:0045921)3.16340693
64positive regulation of insulin secretion (GO:0032024)3.16142071
65proline transport (GO:0015824)3.12631558
66ferric iron transport (GO:0015682)3.11837462
67trivalent inorganic cation transport (GO:0072512)3.11837462
68cellular response to glucagon stimulus (GO:0071377)3.11406304
69adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.10162623
70axonal fasciculation (GO:0007413)3.09442004
71dendritic spine morphogenesis (GO:0060997)3.09249283
72positive regulation of protein homodimerization activity (GO:0090073)3.08078306
73chemosensory behavior (GO:0007635)3.07620459
74regulation of vesicle fusion (GO:0031338)3.06475531
75neuromuscular process controlling posture (GO:0050884)3.03169376
76mitochondrion transport along microtubule (GO:0047497)3.00159802
77establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00159802
78* regulation of peptide hormone secretion (GO:0090276)2.99464025
79energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97952038
80ATP synthesis coupled proton transport (GO:0015986)2.97952038
81protein complex biogenesis (GO:0070271)2.97100957
82* regulation of peptide secretion (GO:0002791)2.96700443
83cellular response to nicotine (GO:0071316)2.96467978
84positive regulation of synapse assembly (GO:0051965)2.96372253
85neurotransmitter-gated ion channel clustering (GO:0072578)2.95612812
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95032545
87activation of protein kinase A activity (GO:0034199)2.94749894
88vesicle coating (GO:0006901)2.94066154
89regulation of cilium movement (GO:0003352)2.92868416
90neuronal action potential (GO:0019228)2.91462841
91COPII vesicle coating (GO:0048208)2.91038943
92sequestering of metal ion (GO:0051238)2.88623649
93axon cargo transport (GO:0008088)2.87866723
94neurotransmitter secretion (GO:0007269)2.87495656
95melanosome transport (GO:0032402)2.86994929
96establishment of synaptic vesicle localization (GO:0097480)2.86751066
97synaptic vesicle transport (GO:0048489)2.86751066
98adaptation of signaling pathway (GO:0023058)2.85614973
99protein localization to synapse (GO:0035418)2.85276675
100regulation of calcium ion-dependent exocytosis (GO:0017158)2.83818743
101mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81916049
102mitochondrial respiratory chain complex I assembly (GO:0032981)2.81916049
103NADH dehydrogenase complex assembly (GO:0010257)2.81916049
104negative regulation of microtubule polymerization (GO:0031115)2.81846301
105regulation of exocytosis (GO:0017157)2.81357830
106positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81106343
107nitric oxide mediated signal transduction (GO:0007263)2.80626579
108regulation of dopamine metabolic process (GO:0042053)2.80160861
109regulation of catecholamine metabolic process (GO:0042069)2.80160861
110regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.79750112
111vesicle transport along microtubule (GO:0047496)2.79522076
112membrane depolarization during action potential (GO:0086010)2.78296859
113protein localization to Golgi apparatus (GO:0034067)2.77717286
114dopamine biosynthetic process (GO:0042416)2.76575817
115positive regulation of vesicle fusion (GO:0031340)2.75718945
116peripheral nervous system neuron development (GO:0048935)2.75373651
117* regulation of hormone secretion (GO:0046883)2.75352172
118G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75136953
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75108800
120regulation of microtubule-based movement (GO:0060632)2.74182723
121positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.72044561
122organelle transport along microtubule (GO:0072384)2.72001309
123establishment of melanosome localization (GO:0032401)2.71767252
124regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71076688
125pigment granule transport (GO:0051904)2.71036998
126vocalization behavior (GO:0071625)2.70716339
127inositol phosphate catabolic process (GO:0071545)2.69877431
128calcium ion-dependent exocytosis (GO:0017156)2.69874036
129response to corticosterone (GO:0051412)2.69748240
130protein polyglutamylation (GO:0018095)2.68926134
131exploration behavior (GO:0035640)2.68415493
132establishment of vesicle localization (GO:0051650)2.67563189
133transmission of nerve impulse (GO:0019226)2.67557300
134platelet dense granule organization (GO:0060155)2.65869847
135synaptic transmission, dopaminergic (GO:0001963)2.65705948
136membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65670308
137locomotory exploration behavior (GO:0035641)2.65155824
138intra-Golgi vesicle-mediated transport (GO:0006891)2.64093032
139* negative regulation of calcium ion transport into cytosol (GO:0010523)2.62625047
140positive regulation of synaptic transmission, GABAergic (GO:0032230)2.62582762
141response to pain (GO:0048265)2.62343299
142activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.61859679
143mitochondrial respiratory chain complex assembly (GO:0033108)2.61698077
144synaptic transmission, glutamatergic (GO:0035249)2.61500673
145neuronal ion channel clustering (GO:0045161)2.61279114
146positive regulation of peptide hormone secretion (GO:0090277)2.60328663
147activation of adenylate cyclase activity (GO:0007190)2.60198336
148positive regulation of peptide secretion (GO:0002793)2.59734083
149phagosome maturation (GO:0090382)2.59378538
150regulation of glucocorticoid secretion (GO:2000849)2.58825104
151cerebellar granule cell differentiation (GO:0021707)2.57580630
152negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57411134
153glandular epithelial cell differentiation (GO:0002067)2.57299837
154establishment of pigment granule localization (GO:0051905)2.57226850
155membrane repolarization (GO:0086009)2.56785680
156synapse assembly (GO:0007416)2.56769434
157behavioral response to ethanol (GO:0048149)2.56721627
158GDP-mannose metabolic process (GO:0019673)2.56690275
159positive regulation of action potential (GO:0045760)2.56104566
160* peptide hormone secretion (GO:0030072)2.56043485
161regulation of neurotransmitter secretion (GO:0046928)2.55851327
162melanosome localization (GO:0032400)2.54057860
163regulation of neurotransmitter uptake (GO:0051580)2.53668941
164positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.53450028
165regulation of synapse structural plasticity (GO:0051823)2.52881194
166auditory behavior (GO:0031223)2.51795426
167positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.51137336
168positive regulation of dendritic spine development (GO:0060999)2.50065520
169regulation of voltage-gated calcium channel activity (GO:1901385)2.48859262
170synaptic vesicle docking involved in exocytosis (GO:0016081)2.48150124
171spinal cord association neuron differentiation (GO:0021527)2.47627754
172neuron-neuron synaptic transmission (GO:0007270)2.46866923
173dopamine transport (GO:0015872)2.45461947
174respiratory electron transport chain (GO:0022904)2.44523660
175adult walking behavior (GO:0007628)2.44454840
176regulation of gene silencing by RNA (GO:0060966)2.43495579
177regulation of posttranscriptional gene silencing (GO:0060147)2.43495579
178regulation of gene silencing by miRNA (GO:0060964)2.43495579
179electron transport chain (GO:0022900)2.42922988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03763444
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.44898357
3REST_21632747_ChIP-Seq_MESCs_Mouse3.17903636
4GBX2_23144817_ChIP-Seq_PC3_Human2.86086917
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78811679
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.64342006
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.60626770
8NR3C1_23031785_ChIP-Seq_PC12_Mouse2.54730103
9* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52602425
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47598860
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39557125
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36717600
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34201766
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34124681
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31470341
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28774961
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25570404
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21356635
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19072593
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.15194968
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.98961773
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.94381866
23VDR_22108803_ChIP-Seq_LS180_Human1.93960744
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.92934865
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91966269
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90678673
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90678673
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90314183
29IGF1R_20145208_ChIP-Seq_DFB_Human1.89492183
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88372539
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87958790
32RNF2_27304074_Chip-Seq_NSC_Mouse1.78607710
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74654981
34IRF1_19129219_ChIP-ChIP_H3396_Human1.70285363
35ZNF274_21170338_ChIP-Seq_K562_Hela1.68449010
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.67862993
37TAF15_26573619_Chip-Seq_HEK293_Human1.65481936
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65144273
39SMAD4_21799915_ChIP-Seq_A2780_Human1.60574225
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.60375808
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.56761933
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54470660
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48280620
44CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.43384460
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39835541
46REST_19997604_ChIP-ChIP_NEURONS_Mouse1.38586183
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37924218
48SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37811019
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37731733
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37675226
51FUS_26573619_Chip-Seq_HEK293_Human1.37472253
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.36610712
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36552776
54P300_19829295_ChIP-Seq_ESCs_Human1.36171749
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34763301
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31972800
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31964856
58EWS_26573619_Chip-Seq_HEK293_Human1.29043105
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26704728
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25807368
61HTT_18923047_ChIP-ChIP_STHdh_Human1.24716433
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22993156
63STAT3_23295773_ChIP-Seq_U87_Human1.22358837
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.20651117
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19276615
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19072491
67BCAT_22108803_ChIP-Seq_LS180_Human1.18174104
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17732964
69AR_25329375_ChIP-Seq_VCAP_Human1.16701700
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14632162
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14596827
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13975991
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13330510
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.12958240
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11510098
76DROSHA_22980978_ChIP-Seq_HELA_Human1.11469637
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11024372
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10724513
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09006234
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08485305
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.07725536
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06697366
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06697366
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06583828
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.05989727
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05379356
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05177926
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04927313
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04776779
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03952025
91JUN_21703547_ChIP-Seq_K562_Human1.03801108
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.02817331
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01902827
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01258274
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01174900
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.00196787
97* NANOG_16153702_ChIP-ChIP_HESCs_Human0.99697396
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99479205
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98217041
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.97939814
101FLI1_21867929_ChIP-Seq_TH2_Mouse0.97110691
102CTCF_27219007_Chip-Seq_Bcells_Human0.96572298
103ERG_21242973_ChIP-ChIP_JURKAT_Human0.95384899
104TP53_22573176_ChIP-Seq_HFKS_Human0.95010843
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94815504
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94799523
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.94602240
108RUNX2_22187159_ChIP-Seq_PCA_Human0.93549186
109ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91368161
110EST1_17652178_ChIP-ChIP_JURKAT_Human0.91356281
111MYC_18940864_ChIP-ChIP_HL60_Human0.90678067
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.89952692
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88855382
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85706503
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.85636019
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85400752
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85212640
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.84720301
119TCF4_22108803_ChIP-Seq_LS180_Human0.84532657
120TCF4_23295773_ChIP-Seq_U87_Human0.84048426
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83287961
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82064467
123SOX2_19829295_ChIP-Seq_ESCs_Human0.82009811
124NANOG_19829295_ChIP-Seq_ESCs_Human0.82009811
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80556043
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.80018027
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79584060
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79556538
129AR_19668381_ChIP-Seq_PC3_Human0.77976845
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.76118139
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74885234
132KDM2B_26808549_Chip-Seq_K562_Human0.73881260
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73645852
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.73434058
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73007890
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73007890
137KDM2B_26808549_Chip-Seq_REH_Human0.72196049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.98741767
2MP0002735_abnormal_chemical_nociception3.94854092
3MP0010386_abnormal_urinary_bladder3.57641498
4MP0003183_abnormal_peptide_metabolism3.45758938
5MP0004859_abnormal_synaptic_plasticity3.28222907
6MP0001968_abnormal_touch/_nociception3.24792185
7MP0001986_abnormal_taste_sensitivity3.16474230
8MP0002909_abnormal_adrenal_gland3.12068415
9MP0006276_abnormal_autonomic_nervous3.09802290
10MP0003121_genomic_imprinting3.05443081
11MP0009780_abnormal_chondrocyte_physiolo3.03406407
12MP0002734_abnormal_mechanical_nocicepti2.98606196
13MP0002733_abnormal_thermal_nociception2.93510803
14MP0003283_abnormal_digestive_organ2.90467754
15MP0008877_abnormal_DNA_methylation2.85333780
16MP0003123_paternal_imprinting2.83195522
17MP0004858_abnormal_nervous_system2.77503880
18MP0005379_endocrine/exocrine_gland_phen2.73006762
19MP0002736_abnormal_nociception_after2.67493333
20MP0001970_abnormal_pain_threshold2.51661552
21MP0002837_dystrophic_cardiac_calcinosis2.51252138
22MP0003635_abnormal_synaptic_transmissio2.44050446
23MP0003880_abnormal_central_pattern2.37780685
24MP0000013_abnormal_adipose_tissue2.36616200
25MP0002877_abnormal_melanocyte_morpholog2.34162160
26MP0004043_abnormal_pH_regulation2.32866777
27* MP0002693_abnormal_pancreas_physiology2.30238115
28MP0002163_abnormal_gland_morphology2.26594046
29MP0006292_abnormal_olfactory_placode2.25644628
30MP0002638_abnormal_pupillary_reflex2.14017191
31MP0001944_abnormal_pancreas_morphology2.04963851
32MP0005394_taste/olfaction_phenotype1.91260374
33MP0005499_abnormal_olfactory_system1.91260374
34MP0002272_abnormal_nervous_system1.90087290
35MP0005645_abnormal_hypothalamus_physiol1.90060708
36MP0002063_abnormal_learning/memory/cond1.84611492
37MP0002064_seizures1.74173794
38MP0009745_abnormal_behavioral_response1.72431669
39MP0002184_abnormal_innervation1.70802979
40MP0002572_abnormal_emotion/affect_behav1.69055125
41MP0008789_abnormal_olfactory_epithelium1.66051025
42MP0002102_abnormal_ear_morphology1.63972460
43MP0003122_maternal_imprinting1.61986630
44MP0004147_increased_porphyrin_level1.59583038
45MP0000678_abnormal_parathyroid_gland1.58762296
46MP0002067_abnormal_sensory_capabilities1.56393912
47MP0003329_amyloid_beta_deposits1.50610545
48MP0002653_abnormal_ependyma_morphology1.50359773
49MP0003890_abnormal_embryonic-extraembry1.49761080
50MP0003195_calcinosis1.48990085
51MP0001501_abnormal_sleep_pattern1.48129620
52MP0009046_muscle_twitch1.47657777
53MP0000955_abnormal_spinal_cord1.47358079
54MP0005646_abnormal_pituitary_gland1.45662336
55MP0005535_abnormal_body_temperature1.40636830
56MP0004811_abnormal_neuron_physiology1.39944561
57MP0002751_abnormal_autonomic_nervous1.36664105
58MP0001440_abnormal_grooming_behavior1.35431308
59MP0003172_abnormal_lysosome_physiology1.31636917
60MP0004133_heterotaxia1.31357153
61MP0003011_delayed_dark_adaptation1.31054314
62MP0003879_abnormal_hair_cell1.30492382
63MP0005084_abnormal_gallbladder_morpholo1.30413835
64* MP0002078_abnormal_glucose_homeostasis1.29938257
65MP0005551_abnormal_eye_electrophysiolog1.29029027
66MP0001502_abnormal_circadian_rhythm1.26104929
67MP0002876_abnormal_thyroid_physiology1.24414737
68MP0001188_hyperpigmentation1.10738441
69MP0002752_abnormal_somatic_nervous1.09589914
70MP0005220_abnormal_exocrine_pancreas1.08901765
71MP0006072_abnormal_retinal_apoptosis1.07643603
72MP0002557_abnormal_social/conspecific_i1.06173810
73MP0002152_abnormal_brain_morphology1.05888881
74MP0000538_abnormal_urinary_bladder1.04003090
75MP0001485_abnormal_pinna_reflex1.03567780
76MP0001984_abnormal_olfaction1.02770270
77MP0002882_abnormal_neuron_morphology1.00890139
78MP0001765_abnormal_ion_homeostasis0.99796076
79MP0004924_abnormal_behavior0.97476054
80MP0005386_behavior/neurological_phenoty0.97476054
81MP0002066_abnormal_motor_capabilities/c0.96103143
82MP0008569_lethality_at_weaning0.94689552
83MP0005423_abnormal_somatic_nervous0.93107766
84MP0004885_abnormal_endolymph0.92757138
85MP0003953_abnormal_hormone_level0.92673477
86MP0001270_distended_abdomen0.92335831
87MP0001905_abnormal_dopamine_level0.92254451
88MP0001348_abnormal_lacrimal_gland0.91965837
89MP0002229_neurodegeneration0.91759777
90MP0008872_abnormal_physiological_respon0.91192157
91MP0003861_abnormal_nervous_system0.91083452
92MP0001293_anophthalmia0.89288663
93MP0006035_abnormal_mitochondrial_morpho0.89152864
94MP0000681_abnormal_thyroid_gland0.88461553
95MP0001486_abnormal_startle_reflex0.88229756
96MP0003633_abnormal_nervous_system0.86623360
97MP0003119_abnormal_digestive_system0.86308377
98MP0003634_abnormal_glial_cell0.84298918
99MP0002233_abnormal_nose_morphology0.83949643
100MP0002928_abnormal_bile_duct0.83778976
101MP0004142_abnormal_muscle_tone0.82108906
102MP0005310_abnormal_salivary_gland0.80851900
103MP0003136_yellow_coat_color0.79563314
104MP0005058_abnormal_lysosome_morphology0.78699194
105MP0000778_abnormal_nervous_system0.78648085
106MP0005187_abnormal_penis_morphology0.77591351
107MP0000372_irregular_coat_pigmentation0.77151509
108MP0008961_abnormal_basal_metabolism0.75879183
109MP0005464_abnormal_platelet_physiology0.75590970
110MP0002090_abnormal_vision0.75002242
111MP0005195_abnormal_posterior_eye0.74971739
112MP0000604_amyloidosis0.74629684
113MP0004742_abnormal_vestibular_system0.73550706
114MP0002069_abnormal_eating/drinking_beha0.73385304
115MP0001963_abnormal_hearing_physiology0.72631222
116MP0008260_abnormal_autophagy0.72253217
117MP0001299_abnormal_eye_distance/0.72057475
118MP0000579_abnormal_nail_morphology0.72044451
119MP0003787_abnormal_imprinting0.69787505
120MP0002938_white_spotting0.69541358
121MP0001756_abnormal_urination0.68410191
122MP0003186_abnormal_redox_activity0.67945226
123MP0002822_catalepsy0.67485982
124MP0003718_maternal_effect0.67431105
125MP0001529_abnormal_vocalization0.67401709
126MP0000613_abnormal_salivary_gland0.67169658
127MP0005448_abnormal_energy_balance0.66485478
128MP0000462_abnormal_digestive_system0.65626652
129MP0005377_hearing/vestibular/ear_phenot0.65408996
130MP0003878_abnormal_ear_physiology0.65408996
131MP0005248_abnormal_Harderian_gland0.65206388
132MP0000631_abnormal_neuroendocrine_gland0.64956021
133MP0000003_abnormal_adipose_tissue0.64746408
134MP0000049_abnormal_middle_ear0.64096778
135MP0001664_abnormal_digestion0.63732112
136MP0003937_abnormal_limbs/digits/tail_de0.62388266
137MP0000639_abnormal_adrenal_gland0.61893366
138MP0003938_abnormal_ear_development0.61268849
139MP0000026_abnormal_inner_ear0.61060416
140* MP0000230_abnormal_systemic_arterial0.60699263
141MP0004145_abnormal_muscle_electrophysio0.59726657
142MP0003631_nervous_system_phenotype0.58847263
143MP0003959_abnormal_lean_body0.58304112
144MP0005636_abnormal_mineral_homeostasis0.58085627

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.10253019
2Pheochromocytoma (HP:0002666)4.59910992
3Visual hallucinations (HP:0002367)4.47833454
4Myokymia (HP:0002411)4.47160138
5Polyphagia (HP:0002591)4.39845991
6Hyperinsulinemic hypoglycemia (HP:0000825)4.30025988
7Hypothermia (HP:0002045)4.23092716
8Neuroendocrine neoplasm (HP:0100634)4.22588639
9Abnormality of calcium-phosphate metabolism (HP:0100530)3.95779196
10Septo-optic dysplasia (HP:0100842)3.88906172
11Hypoglycemic seizures (HP:0002173)3.73776503
12Abnormality of the labia minora (HP:0012880)3.72917562
13Symptomatic seizures (HP:0011145)3.71832436
14Dysautonomia (HP:0002459)3.64145147
15Thoracolumbar scoliosis (HP:0002944)3.62680750
16Abnormal hair whorl (HP:0010721)3.43333246
17Agitation (HP:0000713)3.41155255
18Focal motor seizures (HP:0011153)3.35553335
19Supranuclear gaze palsy (HP:0000605)3.22160531
20Atonic seizures (HP:0010819)3.20323094
21Urinary glycosaminoglycan excretion (HP:0003541)3.19694959
22Mucopolysacchariduria (HP:0008155)3.19694959
23Ulnar claw (HP:0001178)3.17550160
24Hypercortisolism (HP:0001578)3.14107150
25Dysostosis multiplex (HP:0000943)3.10880919
26Hyperparathyroidism (HP:0000843)3.08223559
27Hypoglycemic coma (HP:0001325)3.03372102
28Abnormality of mucopolysaccharide metabolism (HP:0011020)2.96747757
29Abnormality of polysaccharide metabolism (HP:0011012)2.96747757
30Abnormality of glycosaminoglycan metabolism (HP:0004371)2.96747757
31Decreased circulating renin level (HP:0003351)2.96630316
32Abnormality of glycolipid metabolism (HP:0010969)2.96019324
33Abnormality of liposaccharide metabolism (HP:0010968)2.96019324
34Abnormality of glycosphingolipid metabolism (HP:0004343)2.96019324
35Failure to thrive in infancy (HP:0001531)2.83433970
36Drooling (HP:0002307)2.83195569
37Menstrual irregularities (HP:0000858)2.80155841
38Hip dysplasia (HP:0001385)2.75582121
39Hepatoblastoma (HP:0002884)2.75068823
40Papilledema (HP:0001085)2.74999688
41Focal seizures (HP:0007359)2.73231669
42Action tremor (HP:0002345)2.72323692
43Optic nerve hypoplasia (HP:0000609)2.70486034
44Insulin-resistant diabetes mellitus (HP:0000831)2.67265609
45Absence seizures (HP:0002121)2.63083783
46Postural tremor (HP:0002174)2.60276655
47Decreased muscle mass (HP:0003199)2.59285218
48Growth hormone deficiency (HP:0000824)2.57961037
49Lissencephaly (HP:0001339)2.56932421
50Generalized tonic-clonic seizures (HP:0002069)2.56372985
51Medial flaring of the eyebrow (HP:0010747)2.56047988
52Abnormal autonomic nervous system physiology (HP:0012332)2.55887253
53Limb dystonia (HP:0002451)2.55838048
54EEG with generalized epileptiform discharges (HP:0011198)2.54215757
55Epileptiform EEG discharges (HP:0011182)2.54138873
56Impaired vibration sensation in the lower limbs (HP:0002166)2.53999588
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53548418
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53548418
59Excessive salivation (HP:0003781)2.53147080
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51564295
61Abnormal eating behavior (HP:0100738)2.50656083
62Febrile seizures (HP:0002373)2.48405089
63Focal dystonia (HP:0004373)2.48143239
64Hypogonadotrophic hypogonadism (HP:0000044)2.47446494
65Hypsarrhythmia (HP:0002521)2.46731290
66Congenital primary aphakia (HP:0007707)2.45820953
67Acute necrotizing encephalopathy (HP:0006965)2.45177718
68Epileptic encephalopathy (HP:0200134)2.44442890
69Ketoacidosis (HP:0001993)2.43037801
70Abnormality of pain sensation (HP:0010832)2.42706619
71Impaired pain sensation (HP:0007328)2.42706619
72Late onset (HP:0003584)2.42061682
73Nephrogenic diabetes insipidus (HP:0009806)2.40951554
74Absent septum pellucidum (HP:0001331)2.38920945
75Dialeptic seizures (HP:0011146)2.37026511
76Abnormality of magnesium homeostasis (HP:0004921)2.34432356
77Abnormality of the corticospinal tract (HP:0002492)2.34143178
78Neoplasm of the peripheral nervous system (HP:0100007)2.32293391
79Anxiety (HP:0000739)2.32097753
80Hyperglycinemia (HP:0002154)2.31728705
81Vaginal atresia (HP:0000148)2.31112283
82Genital tract atresia (HP:0001827)2.30142706
83Craniofacial dystonia (HP:0012179)2.27991895
84Torticollis (HP:0000473)2.27649399
85Abnormal mitochondria in muscle tissue (HP:0008316)2.26543936
86Spastic tetraplegia (HP:0002510)2.24943174
87Abnormal pancreas size (HP:0012094)2.24318346
88Menorrhagia (HP:0000132)2.22378351
89Amblyopia (HP:0000646)2.21671753
90Progressive cerebellar ataxia (HP:0002073)2.18314422
91Ankle clonus (HP:0011448)2.17927940
92Specific learning disability (HP:0001328)2.17040133
93Depression (HP:0000716)2.16470131
94Hyperthyroidism (HP:0000836)2.14167139
95Restlessness (HP:0000711)2.13445055
96Abnormality of midbrain morphology (HP:0002418)2.12975076
97Molar tooth sign on MRI (HP:0002419)2.12975076
98Renal Fanconi syndrome (HP:0001994)2.12303509
99Termporal pattern (HP:0011008)2.11641818
100Insidious onset (HP:0003587)2.11641818
101Intestinal atresia (HP:0011100)2.11246965
102Progressive macrocephaly (HP:0004481)2.09708806
103Truncal ataxia (HP:0002078)2.09368994
104Increased CSF lactate (HP:0002490)2.08000141
105Hyperglycemia (HP:0003074)2.05525109
106Pancreatic fibrosis (HP:0100732)2.05124300
107Segmental peripheral demyelination/remyelination (HP:0003481)2.04550211
108Sleep apnea (HP:0010535)2.03897995
109Pachygyria (HP:0001302)2.00229668
110Hepatocellular necrosis (HP:0001404)1.99901932
111Adrenal overactivity (HP:0002717)1.99711179
112Cortical dysplasia (HP:0002539)1.99662790
113Progressive neurologic deterioration (HP:0002344)1.98373753
114Poor coordination (HP:0002370)1.97533073
115Hypokalemia (HP:0002900)1.97479599
116X-linked dominant inheritance (HP:0001423)1.96992100
117Broad-based gait (HP:0002136)1.96696059
118Oligomenorrhea (HP:0000876)1.96007004
119Increased mean platelet volume (HP:0011877)1.95234210
120Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94960462
121Cortical visual impairment (HP:0100704)1.94440708
122Mitochondrial inheritance (HP:0001427)1.92566725
123Generalized aminoaciduria (HP:0002909)1.92450176
124Testicular neoplasm (HP:0010788)1.91421388
125Hepatic necrosis (HP:0002605)1.91208834
126Abolished electroretinogram (ERG) (HP:0000550)1.91147314
127Abnormality of endocrine pancreas physiology (HP:0012093)1.90879263
128Abnormality of the pancreatic islet cells (HP:0006476)1.90879263
129Thyroid carcinoma (HP:0002890)1.90676595
130Labial hypoplasia (HP:0000066)1.89347181
131Cerebral edema (HP:0002181)1.88121053
132Type II lissencephaly (HP:0007260)1.85017582
133Spinal canal stenosis (HP:0003416)1.83278965
134Poor suck (HP:0002033)1.83220838
135Psychosis (HP:0000709)1.82852498
136Acute encephalopathy (HP:0006846)1.82704658
137Colon cancer (HP:0003003)1.82487133
138Thyroid-stimulating hormone excess (HP:0002925)1.82345824
139Urinary bladder sphincter dysfunction (HP:0002839)1.81885902
140Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81817281
141Hypotension (HP:0002615)1.81607147
142Orthostatic hypotension (HP:0001278)1.80580912
143Anosmia (HP:0000458)1.80408133
144Bifid tongue (HP:0010297)1.79889726
145Urinary urgency (HP:0000012)1.79685882
146Delusions (HP:0000746)1.78414465
147Nasal speech (HP:0001611)1.78069537
148Abnormality of the septum pellucidum (HP:0007375)1.77623651
149Prolonged bleeding time (HP:0003010)1.77432440
150Osteomalacia (HP:0002749)1.77052686
151Long foot (HP:0001833)1.76783878
152Nephronophthisis (HP:0000090)1.76368460
153Morphological abnormality of the pyramidal tract (HP:0002062)1.75554905
154Broad alveolar ridges (HP:0000187)1.75544115
155Retinal dysplasia (HP:0007973)1.75425305
156Methylmalonic acidemia (HP:0002912)1.74504674
157Hypomagnesemia (HP:0002917)1.74193307
158Hypoplastic female external genitalia (HP:0012815)1.74034856
159Flared iliac wings (HP:0002869)1.73720299
160Narrow forehead (HP:0000341)1.73650386
161Protuberant abdomen (HP:0001538)1.73140542
162Gait imbalance (HP:0002141)1.73041739
163Scrotal hypoplasia (HP:0000046)1.72415453
164Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71290428
165Degeneration of the lateral corticospinal tracts (HP:0002314)1.71290428
1663-Methylglutaconic aciduria (HP:0003535)1.70438270
167Upper limb muscle weakness (HP:0003484)1.70075723
168Supernumerary spleens (HP:0009799)1.70016314
169Growth hormone excess (HP:0000845)1.69953170
170Decreased testicular size (HP:0008734)1.69934169
171Episodic fever (HP:0001954)1.69846830
172Large for gestational age (HP:0001520)1.69571406
173Submucous cleft hard palate (HP:0000176)1.69039427
174Vacuolated lymphocytes (HP:0001922)1.68182820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK14.08006560
2NTRK34.06823272
3INSRR3.88515262
4PRKD33.14418460
5MAP3K23.01490976
6PASK2.98129851
7WNK32.77910834
8MINK12.71847100
9GRK52.66429816
10MAP3K92.50283642
11KSR22.45114696
12ARAF2.44419259
13RIPK42.40943152
14TNIK2.27389033
15MAP3K122.10887636
16STK161.91408542
17CAMKK21.90701619
18MAP2K71.87935818
19HIPK21.86748680
20MAP4K21.81636283
21MAPK151.75806096
22TRIM281.74757689
23MAP3K41.70702159
24MKNK21.68393703
25MARK11.67848647
26LIMK11.53633533
27EPHA31.53535770
28SIK31.48774782
29MAP3K11.46043077
30RET1.44577303
31CSNK1G11.41580842
32DYRK31.36583377
33PNCK1.34377100
34GRK11.32528305
35BRAF1.28733115
36DAPK21.25722348
37SCYL21.23734711
38CDK191.22075766
39MST41.22022490
40FLT31.21414594
41CASK1.21017469
42WNK41.17551998
43MAP2K41.16565827
44ZAK1.16529560
45MAPK131.16003927
46CAMKK11.13940927
47PLK31.13881466
48TAOK31.13167648
49PLK21.12864113
50UHMK11.12576097
51CSNK1A1L1.12278849
52PAK61.08199203
53BMPR21.07349501
54CDK51.07190055
55CDC42BPA1.07019739
56DAPK11.06199869
57TESK11.05194060
58TYRO31.01790052
59PRKCG1.00428864
60RPS6KA21.00233815
61PRKCE0.99652384
62AKT30.97626474
63BMX0.95871812
64ERN10.92556407
65EPHB20.92087050
66DYRK1A0.90422141
67LMTK20.85017441
68MKNK10.83636460
69PIM20.83077670
70MAP2K10.83071795
71PAK30.82730660
72CSNK1E0.82690024
73BCR0.82194507
74IRAK10.81747369
75PRKCH0.78342497
76FER0.77739842
77FRK0.77484177
78STK110.77298889
79PHKG10.75421803
80PHKG20.75421803
81CAMK2D0.74629331
82CAMK1G0.74245018
83NME10.73473390
84OXSR10.70925881
85CDK140.67335833
86KSR10.67316046
87BMPR1B0.64022833
88PKN10.63184991
89PTK20.62344892
90EPHA40.62080472
91MAPKAPK30.61968308
92LATS20.61935584
93CAMK10.61822096
94MATK0.59553877
95ALK0.59093548
96CAMK2A0.58701001
97ILK0.58462353
98SGK4940.58368538
99SGK2230.58368538
100CSNK1G20.58094521
101PLK10.57291708
102PAK10.56637154
103MAP2K20.56629495
104ADRBK10.55873417
105MYLK0.55084940
106PTK2B0.55055814
107CAMK2B0.54713987
108ADRBK20.51886271
109DYRK1B0.51648305
110DMPK0.49388134
111DAPK30.48750026
112SGK20.47720931
113CDK180.47558464
114PRKG10.47054488
115CDC70.46545590
116BCKDK0.44488033
117TAOK10.43832144
118PINK10.42777954
119SYK0.42648106
120FGR0.41837476
121PRKACA0.41126075
122PDPK10.39967449
123VRK10.39772627
124STK30.38697041
125PRKCA0.38677700
126PLK40.38379785
127SRPK10.37881843
128CDK150.37724167
129IRAK20.37592057
130ERBB20.37162644
131PRKCZ0.36995159
132NTRK20.36813802
133WNK10.35778716
134CSNK1G30.35772352
135MET0.35540725
136CAMK2G0.35445602
137PRKACG0.34864356
138PDGFRA0.34556922
139CSNK1A10.33744730
140PRKCI0.33326784
141BRSK10.33010746
142DYRK20.32678163
143FES0.30772414
144CDK11A0.29446413
145EIF2AK30.28396825
146MARK30.27535540

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.47431863
2Protein export_Homo sapiens_hsa030603.50058566
3Synaptic vesicle cycle_Homo sapiens_hsa047213.36898131
4Insulin secretion_Homo sapiens_hsa049112.95237939
5Vibrio cholerae infection_Homo sapiens_hsa051102.77651467
6Steroid biosynthesis_Homo sapiens_hsa001002.65176411
7Collecting duct acid secretion_Homo sapiens_hsa049662.63250165
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44861288
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.29884557
10Oxidative phosphorylation_Homo sapiens_hsa001902.18049768
11Taste transduction_Homo sapiens_hsa047422.07320564
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98623530
13Amphetamine addiction_Homo sapiens_hsa050311.95805001
14Long-term potentiation_Homo sapiens_hsa047201.95615460
15Phototransduction_Homo sapiens_hsa047441.90440289
16Dopaminergic synapse_Homo sapiens_hsa047281.79921177
17Cocaine addiction_Homo sapiens_hsa050301.76380944
18Type II diabetes mellitus_Homo sapiens_hsa049301.73139251
19Circadian entrainment_Homo sapiens_hsa047131.71622518
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.68844233
21Sulfur metabolism_Homo sapiens_hsa009201.67996035
22Parkinsons disease_Homo sapiens_hsa050121.67543656
23Serotonergic synapse_Homo sapiens_hsa047261.63584469
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61312478
25Cholinergic synapse_Homo sapiens_hsa047251.59025023
26Alzheimers disease_Homo sapiens_hsa050101.57480014
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50912182
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.49671437
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48368073
30GABAergic synapse_Homo sapiens_hsa047271.44380727
31Nicotine addiction_Homo sapiens_hsa050331.42155330
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38332257
33Type I diabetes mellitus_Homo sapiens_hsa049401.37635002
34Regulation of autophagy_Homo sapiens_hsa041401.35392193
35Morphine addiction_Homo sapiens_hsa050321.31984490
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31305418
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30416598
38Lysosome_Homo sapiens_hsa041421.28355308
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24831781
40Olfactory transduction_Homo sapiens_hsa047401.24121236
41Glutamatergic synapse_Homo sapiens_hsa047241.23321343
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22553822
43Axon guidance_Homo sapiens_hsa043601.21388163
44Cardiac muscle contraction_Homo sapiens_hsa042601.11285466
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08762518
46Huntingtons disease_Homo sapiens_hsa050161.07848044
47RNA polymerase_Homo sapiens_hsa030201.05126821
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03427852
49Phagosome_Homo sapiens_hsa041451.03223175
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01882677
51Fatty acid elongation_Homo sapiens_hsa000621.01128511
52Salivary secretion_Homo sapiens_hsa049700.99307214
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98123396
54Long-term depression_Homo sapiens_hsa047300.98086765
55Thyroid hormone synthesis_Homo sapiens_hsa049180.94331851
56Renin secretion_Homo sapiens_hsa049240.93312108
57Rheumatoid arthritis_Homo sapiens_hsa053230.92751313
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.91879007
59Pancreatic secretion_Homo sapiens_hsa049720.91093994
60Estrogen signaling pathway_Homo sapiens_hsa049150.90397870
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89476036
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88163002
63Arginine and proline metabolism_Homo sapiens_hsa003300.88013429
64Folate biosynthesis_Homo sapiens_hsa007900.87873150
65Selenocompound metabolism_Homo sapiens_hsa004500.87433897
66Prolactin signaling pathway_Homo sapiens_hsa049170.87207385
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86519806
68Proteasome_Homo sapiens_hsa030500.86162760
69N-Glycan biosynthesis_Homo sapiens_hsa005100.83960676
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82522713
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82164348
72Basal transcription factors_Homo sapiens_hsa030220.82104601
73Propanoate metabolism_Homo sapiens_hsa006400.81162541
74Fat digestion and absorption_Homo sapiens_hsa049750.81024639
75Gastric acid secretion_Homo sapiens_hsa049710.79240822
76GnRH signaling pathway_Homo sapiens_hsa049120.78922676
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77649069
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77498695
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77200485
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77192301
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.76591843
82Glucagon signaling pathway_Homo sapiens_hsa049220.75067505
83Prion diseases_Homo sapiens_hsa050200.72574758
84Gap junction_Homo sapiens_hsa045400.72123732
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71314505
86beta-Alanine metabolism_Homo sapiens_hsa004100.70658730
87Mismatch repair_Homo sapiens_hsa034300.68649044
88Hippo signaling pathway_Homo sapiens_hsa043900.67744692
89Ether lipid metabolism_Homo sapiens_hsa005650.67535985
90Thyroid cancer_Homo sapiens_hsa052160.67325813
91Butanoate metabolism_Homo sapiens_hsa006500.67219145
92Glioma_Homo sapiens_hsa052140.66275864
93Linoleic acid metabolism_Homo sapiens_hsa005910.65942869
94Dorso-ventral axis formation_Homo sapiens_hsa043200.65507849
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64974143
96Nitrogen metabolism_Homo sapiens_hsa009100.64911434
97Insulin signaling pathway_Homo sapiens_hsa049100.64807248
98Hedgehog signaling pathway_Homo sapiens_hsa043400.64549947
99Oxytocin signaling pathway_Homo sapiens_hsa049210.64288625
100Calcium signaling pathway_Homo sapiens_hsa040200.63855194
101cAMP signaling pathway_Homo sapiens_hsa040240.63295231
102Wnt signaling pathway_Homo sapiens_hsa043100.63047833
103Alcoholism_Homo sapiens_hsa050340.62333722
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61894536
105Metabolic pathways_Homo sapiens_hsa011000.61732698
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60569149
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.59833273
108Vitamin B6 metabolism_Homo sapiens_hsa007500.59153641
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58895005
110Ribosome_Homo sapiens_hsa030100.58411611
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58046021
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57710486
113Pyruvate metabolism_Homo sapiens_hsa006200.56803880
114Melanogenesis_Homo sapiens_hsa049160.56633508
115Peroxisome_Homo sapiens_hsa041460.56631499
116Galactose metabolism_Homo sapiens_hsa000520.54996459
117Glutathione metabolism_Homo sapiens_hsa004800.53284590
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.52807264
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52704539
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52092733
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49935939
122Purine metabolism_Homo sapiens_hsa002300.49904553
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47820641
124Basal cell carcinoma_Homo sapiens_hsa052170.46000721
125Circadian rhythm_Homo sapiens_hsa047100.45794123
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44688142
127Oocyte meiosis_Homo sapiens_hsa041140.44085558
128Arachidonic acid metabolism_Homo sapiens_hsa005900.43991377
129Other glycan degradation_Homo sapiens_hsa005110.43070996
130RNA degradation_Homo sapiens_hsa030180.42161056
131Endocytosis_Homo sapiens_hsa041440.41935994
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41902187
133Tight junction_Homo sapiens_hsa045300.41581170
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40676572
135ErbB signaling pathway_Homo sapiens_hsa040120.40616216
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39523554
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38966944
138Insulin resistance_Homo sapiens_hsa049310.37246591
139Tuberculosis_Homo sapiens_hsa051520.34519559
140Choline metabolism in cancer_Homo sapiens_hsa052310.32361828
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.31165237
142VEGF signaling pathway_Homo sapiens_hsa043700.30388779
143mTOR signaling pathway_Homo sapiens_hsa041500.30260433
144Endometrial cancer_Homo sapiens_hsa052130.30126289
145MAPK signaling pathway_Homo sapiens_hsa040100.28942108
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.28337277
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26880253
148Sphingolipid metabolism_Homo sapiens_hsa006000.25580570
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.24821624
150Ras signaling pathway_Homo sapiens_hsa040140.24011026

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