FKBP1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.78192872
2cytidine metabolic process (GO:0046087)7.53822040
3cytidine catabolic process (GO:0006216)7.53822040
4cytidine deamination (GO:0009972)7.53822040
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.88408522
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.57148278
7protein neddylation (GO:0045116)5.01310694
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.75449774
9proteasome assembly (GO:0043248)4.50814163
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.47102653
11ATP synthesis coupled proton transport (GO:0015986)4.47102653
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.40389000
13platelet dense granule organization (GO:0060155)4.32191058
14protein complex biogenesis (GO:0070271)4.30667261
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.21636719
16sequestering of actin monomers (GO:0042989)4.06788994
17electron transport chain (GO:0022900)4.00442191
18respiratory electron transport chain (GO:0022904)3.99899892
19regulation of cellular amino acid metabolic process (GO:0006521)3.94459846
20positive regulation of interleukin-8 secretion (GO:2000484)3.88018121
21mitochondrial respiratory chain complex assembly (GO:0033108)3.86438807
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63294808
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61021944
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.61021944
25NADH dehydrogenase complex assembly (GO:0010257)3.61021944
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.60309383
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.60309383
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59677943
29mannosylation (GO:0097502)3.58142270
30negative regulation by host of viral transcription (GO:0043922)3.52806607
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48970489
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48970489
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48600751
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48600751
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48600751
36chaperone-mediated protein transport (GO:0072321)3.46284703
37Arp2/3 complex-mediated actin nucleation (GO:0034314)3.44965548
38negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.39334542
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36623697
40regulation of interleukin-8 secretion (GO:2000482)3.31138510
41respiratory chain complex IV assembly (GO:0008535)3.30690876
42signal transduction involved in DNA damage checkpoint (GO:0072422)3.26474655
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26474655
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26248432
45eosinophil chemotaxis (GO:0048245)3.24545432
46signal transduction involved in cell cycle checkpoint (GO:0072395)3.24012964
47actin nucleation (GO:0045010)3.20258124
48pyrimidine nucleoside catabolic process (GO:0046135)3.19609028
49DNA demethylation (GO:0080111)3.18819655
50water-soluble vitamin biosynthetic process (GO:0042364)3.18466124
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18378008
52cytochrome complex assembly (GO:0017004)3.17814403
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17741500
54negative regulation of ligase activity (GO:0051352)3.17741500
55iron-sulfur cluster assembly (GO:0016226)3.16928675
56metallo-sulfur cluster assembly (GO:0031163)3.16928675
57termination of RNA polymerase III transcription (GO:0006386)3.12729775
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.12729775
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.11661889
60protein deneddylation (GO:0000338)3.11006892
61regulation of activation of Janus kinase activity (GO:0010533)3.10860883
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09761847
63protein-cofactor linkage (GO:0018065)3.00072469
64GPI anchor metabolic process (GO:0006505)2.98624001
65rRNA modification (GO:0000154)2.93573788
66eosinophil migration (GO:0072677)2.92869558
67antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.90725794
68GPI anchor biosynthetic process (GO:0006506)2.89019833
69hydrogen ion transmembrane transport (GO:1902600)2.88926739
70cullin deneddylation (GO:0010388)2.86934681
71regulation of chronic inflammatory response (GO:0002676)2.85818945
72proton transport (GO:0015992)2.81599400
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80066469
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80020802
75adenosine metabolic process (GO:0046085)2.79670279
76regulation of regulatory T cell differentiation (GO:0045589)2.78956502
77regulation of cellular amine metabolic process (GO:0033238)2.78950871
78hydrogen transport (GO:0006818)2.76253048
79positive regulation of cell cycle arrest (GO:0071158)2.75351557
80protein maturation by protein folding (GO:0022417)2.72266493
81positive regulation of ligase activity (GO:0051351)2.69429249
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.69117697
83positive regulation of defense response to virus by host (GO:0002230)2.67402556
84ATP biosynthetic process (GO:0006754)2.67123308
85deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.59752915
86negative regulation of viral genome replication (GO:0045071)2.58871042
87response to pheromone (GO:0019236)2.58118836
88negative regulation of T cell apoptotic process (GO:0070233)2.58094567
89purine nucleoside triphosphate biosynthetic process (GO:0009145)2.55860335
90DNA dealkylation (GO:0035510)2.53702715
91negative regulation of telomere maintenance (GO:0032205)2.51610449
92branched-chain amino acid catabolic process (GO:0009083)2.49683966
93purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.47853444
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.46924881
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45589809
96rRNA methylation (GO:0031167)2.45568400
97response to interferon-beta (GO:0035456)2.43704356
98cytolysis (GO:0019835)2.43611803
99intracellular protein transmembrane import (GO:0044743)2.42975552
100DNA double-strand break processing (GO:0000729)2.42744347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12326074
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.02900286
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.92262515
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.62133963
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.53473099
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.08999703
7VDR_22108803_ChIP-Seq_LS180_Human2.94513504
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86733241
9ZNF274_21170338_ChIP-Seq_K562_Hela2.57745497
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57175634
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52409178
12VDR_23849224_ChIP-Seq_CD4+_Human2.47573591
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36581090
14ELK1_19687146_ChIP-ChIP_HELA_Human2.23784548
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.13739571
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.11386270
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09472511
18IGF1R_20145208_ChIP-Seq_DFB_Human2.08227040
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.01805189
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97376839
21FOXP3_21729870_ChIP-Seq_TREG_Human1.91256538
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83669453
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77920586
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77907467
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77901428
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.73102219
27EWS_26573619_Chip-Seq_HEK293_Human1.68519356
28MYC_18940864_ChIP-ChIP_HL60_Human1.66501625
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65802269
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64883439
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61507706
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60315259
33HTT_18923047_ChIP-ChIP_STHdh_Human1.59974590
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59474719
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51387740
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51183990
37TP53_22573176_ChIP-Seq_HFKS_Human1.51051808
38NANOG_19829295_ChIP-Seq_ESCs_Human1.50292668
39SOX2_19829295_ChIP-Seq_ESCs_Human1.50292668
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47036626
41P300_19829295_ChIP-Seq_ESCs_Human1.46187854
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45075500
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.44738108
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44738108
45GBX2_23144817_ChIP-Seq_PC3_Human1.44226573
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41257791
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40256519
48FUS_26573619_Chip-Seq_HEK293_Human1.37323017
49AR_20517297_ChIP-Seq_VCAP_Human1.34124546
50ER_23166858_ChIP-Seq_MCF-7_Human1.34014368
51GATA3_26560356_Chip-Seq_TH2_Human1.29318163
52TAF15_26573619_Chip-Seq_HEK293_Human1.27569485
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26780779
54BCAT_22108803_ChIP-Seq_LS180_Human1.25371552
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25126592
56FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24967997
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23563876
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22985133
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20950239
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.19003137
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18853543
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.17339589
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15254075
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14749655
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14474533
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.13672334
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13545694
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10791618
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09356187
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08862682
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08559646
72NCOR_22424771_ChIP-Seq_293T_Human1.06952555
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06875554
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05797518
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04966023
76CBP_20019798_ChIP-Seq_JUKART_Human1.04966023
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.04691204
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.02245732
79ERG_20517297_ChIP-Seq_VCAP_Human1.01787718
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.01405173
81NANOG_20526341_ChIP-Seq_ESCs_Human1.00940242
82MYB_26560356_Chip-Seq_TH2_Human1.00713847
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.99799106
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.99533803
85BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97172878
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96378536
87IRF1_19129219_ChIP-ChIP_H3396_Human0.96294827
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96010260
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95317004
90DCP1A_22483619_ChIP-Seq_HELA_Human0.94552987
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92926151
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92862194
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92440025
94TCF4_22108803_ChIP-Seq_LS180_Human0.92394244
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92281718
96MYC_19829295_ChIP-Seq_ESCs_Human0.92036472
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91333142
98HOXB7_26014856_ChIP-Seq_BT474_Human0.88215688
99TAF2_19829295_ChIP-Seq_ESCs_Human0.87220323
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86239441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.10600702
2MP0002102_abnormal_ear_morphology3.57121595
3MP0003195_calcinosis3.42842028
4MP0006072_abnormal_retinal_apoptosis2.63128883
5MP0009785_altered_susceptibility_to2.39678051
6MP0008877_abnormal_DNA_methylation2.36551921
7MP0002837_dystrophic_cardiac_calcinosis2.35882749
8MP0005084_abnormal_gallbladder_morpholo2.31977507
9MP0002138_abnormal_hepatobiliary_system1.92628881
10MP0006082_CNS_inflammation1.89416519
11MP0001835_abnormal_antigen_presentation1.89261179
12MP0006036_abnormal_mitochondrial_physio1.84312822
13MP0005645_abnormal_hypothalamus_physiol1.83547120
14MP0006054_spinal_hemorrhage1.81132772
15MP0000372_irregular_coat_pigmentation1.77062602
16MP0003011_delayed_dark_adaptation1.76338831
17MP0001905_abnormal_dopamine_level1.75977951
18MP0002163_abnormal_gland_morphology1.73430599
19MP0008872_abnormal_physiological_respon1.71464911
20MP0003786_premature_aging1.71392430
21MP0002148_abnormal_hypersensitivity_rea1.66258383
22MP0005551_abnormal_eye_electrophysiolog1.64549241
23MP0005075_abnormal_melanosome_morpholog1.63495389
24MP0009333_abnormal_splenocyte_physiolog1.63180543
25MP0005253_abnormal_eye_physiology1.61402523
26MP0002736_abnormal_nociception_after1.55268724
27MP0003806_abnormal_nucleotide_metabolis1.51114435
28MP0002277_abnormal_respiratory_mucosa1.50177172
29MP0002166_altered_tumor_susceptibility1.46364496
30MP0005379_endocrine/exocrine_gland_phen1.43009319
31MP0002876_abnormal_thyroid_physiology1.42646150
32MP0001485_abnormal_pinna_reflex1.38184837
33MP0001968_abnormal_touch/_nociception1.37974589
34MP0004145_abnormal_muscle_electrophysio1.33993558
35MP0005000_abnormal_immune_tolerance1.33313267
36MP0005646_abnormal_pituitary_gland1.30707032
37MP0004147_increased_porphyrin_level1.30623922
38MP0003866_abnormal_defecation1.26041514
39MP0005389_reproductive_system_phenotype1.25038211
40MP0008875_abnormal_xenobiotic_pharmacok1.24850601
41MP0008058_abnormal_DNA_repair1.23603838
42MP0001919_abnormal_reproductive_system1.22163169
43MP0001529_abnormal_vocalization1.20432213
44MP0003186_abnormal_redox_activity1.19869359
45MP0001984_abnormal_olfaction1.18910791
46MP0002006_tumorigenesis1.15476523
47MP0002693_abnormal_pancreas_physiology1.14383987
48MP0000516_abnormal_urinary_system1.13590768
49MP0005367_renal/urinary_system_phenotyp1.13590768
50MP0002723_abnormal_immune_serum1.13093776
51MP0001800_abnormal_humoral_immune1.12905448
52MP0008995_early_reproductive_senescence1.10996737
53MP0010386_abnormal_urinary_bladder1.10418916
54MP0002733_abnormal_thermal_nociception1.09293886
55MP0006276_abnormal_autonomic_nervous1.08779343
56MP0004142_abnormal_muscle_tone1.08299984
57MP0002420_abnormal_adaptive_immunity1.07950515
58MP0005636_abnormal_mineral_homeostasis1.06471130
59MP0001819_abnormal_immune_cell1.06027545
60MP0001764_abnormal_homeostasis1.05824767
61MP0005410_abnormal_fertilization1.04858314
62MP0005387_immune_system_phenotype1.04550801
63MP0001790_abnormal_immune_system1.04550801
64MP0005025_abnormal_response_to1.04544293
65MP0003880_abnormal_central_pattern1.02607121
66MP0004043_abnormal_pH_regulation1.02012638
67MP0003763_abnormal_thymus_physiology0.99406225
68MP0002234_abnormal_pharynx_morphology0.99351147
69MP0003045_fibrosis0.99122604
70MP0006035_abnormal_mitochondrial_morpho0.98502171
71MP0003787_abnormal_imprinting0.98419996
72MP0003567_abnormal_fetal_cardiomyocyte0.98377496
73MP0003724_increased_susceptibility_to0.97531340
74MP0005464_abnormal_platelet_physiology0.95408707
75MP0003137_abnormal_impulse_conducting0.94731391
76MP0006292_abnormal_olfactory_placode0.94608339
77MP0001188_hyperpigmentation0.94126468
78MP0002638_abnormal_pupillary_reflex0.93595465
79MP0009745_abnormal_behavioral_response0.91645027
80MP0009046_muscle_twitch0.91060326
81MP0001873_stomach_inflammation0.90816408
82MP0002452_abnormal_antigen_presenting0.89044043
83MP0004885_abnormal_endolymph0.88225242
84MP0004215_abnormal_myocardial_fiber0.87679271
85MP0003718_maternal_effect0.86678789
86MP0005167_abnormal_blood-brain_barrier0.84865066
87MP0001845_abnormal_inflammatory_respons0.84561708
88MP0002272_abnormal_nervous_system0.82437090
89MP0001970_abnormal_pain_threshold0.81573259
90MP0008789_abnormal_olfactory_epithelium0.80363660
91MP0003283_abnormal_digestive_organ0.79203260
92MP0005332_abnormal_amino_acid0.78513953
93MP0000689_abnormal_spleen_morphology0.78265954
94MP0008007_abnormal_cellular_replicative0.77961862
95MP0002160_abnormal_reproductive_system0.77786698
96MP0003119_abnormal_digestive_system0.75498921
97MP0000716_abnormal_immune_system0.75345110
98MP0002751_abnormal_autonomic_nervous0.73465966
99MP0002933_joint_inflammation0.72656179
100MP0000631_abnormal_neuroendocrine_gland0.72632309

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.87962548
2Mitochondrial inheritance (HP:0001427)4.59610770
3Abnormal mitochondria in muscle tissue (HP:0008316)4.48160217
4Progressive macrocephaly (HP:0004481)4.27512882
5Increased CSF lactate (HP:0002490)4.13587078
6Hepatocellular necrosis (HP:0001404)4.13302065
7Acute encephalopathy (HP:0006846)3.98432372
8Hepatic necrosis (HP:0002605)3.91515631
93-Methylglutaconic aciduria (HP:0003535)3.69547385
10Aplastic anemia (HP:0001915)3.50720940
11Increased hepatocellular lipid droplets (HP:0006565)3.29171356
12Type I transferrin isoform profile (HP:0003642)3.23909565
13Renal Fanconi syndrome (HP:0001994)3.23023118
14Cerebral edema (HP:0002181)3.22292983
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21523743
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21523743
17Methylmalonic acidemia (HP:0002912)3.09825259
18Lipid accumulation in hepatocytes (HP:0006561)3.07965376
19Pancreatic cysts (HP:0001737)3.06947771
20Hypoproteinemia (HP:0003075)3.06570181
21Methylmalonic aciduria (HP:0012120)2.88179601
22Renal cortical cysts (HP:0000803)2.83737275
23Increased intramyocellular lipid droplets (HP:0012240)2.79720784
24True hermaphroditism (HP:0010459)2.73819248
25Congenital, generalized hypertrichosis (HP:0004540)2.72708474
26Increased serum lactate (HP:0002151)2.71743952
27Congenital stationary night blindness (HP:0007642)2.69600654
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69463297
29Abnormal protein N-linked glycosylation (HP:0012347)2.69463297
30Abnormal protein glycosylation (HP:0012346)2.69463297
31Abnormal glycosylation (HP:0012345)2.69463297
32IgG deficiency (HP:0004315)2.69403787
33Abnormality of midbrain morphology (HP:0002418)2.66673973
34Molar tooth sign on MRI (HP:0002419)2.66673973
35Lactic acidosis (HP:0003128)2.64502889
36Pancreatic fibrosis (HP:0100732)2.63471662
37Respiratory failure (HP:0002878)2.60851343
38Generalized aminoaciduria (HP:0002909)2.53664644
39Optic disc pallor (HP:0000543)2.53189210
40Exertional dyspnea (HP:0002875)2.51335318
41Abnormality of the prostate (HP:0008775)2.46441818
42Abnormality of T cell number (HP:0011839)2.46173092
43Abolished electroretinogram (ERG) (HP:0000550)2.41338516
44Ketoacidosis (HP:0001993)2.35513742
45Medial flaring of the eyebrow (HP:0010747)2.33566595
46T lymphocytopenia (HP:0005403)2.31225607
47Increased muscle lipid content (HP:0009058)2.29239963
48Abnormality of the renal cortex (HP:0011035)2.28212304
49Lethargy (HP:0001254)2.27018416
50Hypothermia (HP:0002045)2.25650847
51Abnormality of renal resorption (HP:0011038)2.24109308
52Stomatitis (HP:0010280)2.16278036
53Thyroiditis (HP:0100646)2.14285434
54Type 2 muscle fiber atrophy (HP:0003554)2.13517846
55Ketosis (HP:0001946)2.12987044
56Colon cancer (HP:0003003)2.12408285
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11395479
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09643233
59Abnormality of B cell number (HP:0010975)2.08334887
60Nephronophthisis (HP:0000090)2.06925147
61Exercise intolerance (HP:0003546)2.05985058
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05297345
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03386157
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02400353
65Dicarboxylic aciduria (HP:0003215)2.02400353
66Abnormality of urine glucose concentration (HP:0011016)2.01799234
67Glycosuria (HP:0003076)2.01799234
68Hypoalbuminemia (HP:0003073)2.01724173
69Abnormal albumin level (HP:0012116)2.01724173
70Attenuation of retinal blood vessels (HP:0007843)1.99725317
71Leukodystrophy (HP:0002415)1.98923478
72Abnormal rod and cone electroretinograms (HP:0008323)1.96047655
73Abnormality of vitamin B metabolism (HP:0004340)1.95715901
74Hypomagnesemia (HP:0002917)1.95099431
75Severe combined immunodeficiency (HP:0004430)1.94753662
76Abnormality of methionine metabolism (HP:0010901)1.94008484
77CNS demyelination (HP:0007305)1.92817285
78Abnormality of T cells (HP:0002843)1.89523954
79Aplasia/hypoplasia of the uterus (HP:0008684)1.87340470
80Hypoglycemic coma (HP:0001325)1.86987503
81Increased IgM level (HP:0003496)1.83688635
82Pancytopenia (HP:0001876)1.82239823
83Reduced antithrombin III activity (HP:0001976)1.81159532
84Abnormality of the vitamin B12 metabolism (HP:0004341)1.80377467
85Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79297454
86Abnormality of eosinophils (HP:0001879)1.78653372
87Autoimmune hemolytic anemia (HP:0001890)1.78567463
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73822489
89Abnormality of alanine metabolism (HP:0010916)1.73822489
90Hyperalaninemia (HP:0003348)1.73822489
91Sclerocornea (HP:0000647)1.71773034
92Pendular nystagmus (HP:0012043)1.70883869
93Tongue fasciculations (HP:0001308)1.70404161
94Muscle fiber atrophy (HP:0100295)1.70244811
95Elevated erythrocyte sedimentation rate (HP:0003565)1.69634820
96Hyperinsulinemic hypoglycemia (HP:0000825)1.69059725
97Congenital primary aphakia (HP:0007707)1.68429931
98Decreased central vision (HP:0007663)1.68412116
99Emotional lability (HP:0000712)1.67953894
100Abnormality of the renal medulla (HP:0100957)1.65724021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.71558331
2MST43.39458259
3TXK3.26521655
4KDR3.15371746
5BMPR1B2.95585330
6BCKDK2.82639101
7FRK2.58265987
8TRIM282.30951533
9MAP4K22.25931971
10ADRBK22.22410692
11NUAK12.19522801
12TESK22.11846077
13GRK12.06858873
14ZAK2.06438858
15VRK12.05014295
16MAP3K121.97331746
17LIMK11.84918028
18WNK31.80221962
19TLK11.77035592
20TESK11.67966408
21TIE11.67372633
22CSNK1G31.52090102
23PINK11.49938491
24ERBB31.46504620
25TAOK31.38829926
26STK161.38377884
27BUB11.35276077
28CSNK1G11.30675996
29TAF11.30628328
30MYLK1.28024160
31CSNK1A1L1.25806751
32ITK1.25784705
33CSNK1G21.25001231
34PLK21.21573102
35INSRR1.19422692
36TEC1.10032546
37PASK1.03246932
38PLK31.02906219
39DAPK10.99375890
40EIF2AK30.90568920
41GRK50.89920195
42PRKCQ0.89901545
43DYRK20.89791019
44BCR0.89051596
45OXSR10.88816499
46ACVR1B0.88267441
47WNK40.87846455
48TNIK0.86730535
49IKBKB0.85837218
50GRK70.82267186
51PHKG20.81006416
52PHKG10.81006416
53EIF2AK10.80147558
54GRK60.80117059
55FES0.79756278
56SRPK10.71677085
57DAPK20.71255801
58MAP2K70.65819522
59PRKCE0.63391151
60ADRBK10.62893085
61SYK0.60569337
62NEK10.59969111
63MAPK130.57592236
64RPS6KA50.57430706
65PIK3CG0.54618626
66BMPR20.54231970
67PAK30.54170417
68LCK0.51761036
69STK390.47086188
70TGFBR10.46111199
71IGF1R0.45941906
72PTK2B0.45924064
73FER0.45381913
74MAPKAPK50.45338774
75MAP4K10.45254073
76ROCK10.43268484
77PRKCG0.43200958
78CAMKK20.41880096
79CAMK2A0.41473203
80DAPK30.40714992
81LYN0.39122129
82OBSCN0.38025846
83NME10.36735888
84MAP3K40.36326348
85CSNK1A10.34750018
86KIT0.34738466
87PRKCA0.34296297
88PRKACA0.33568276
89MINK10.33519038
90IKBKE0.33481937
91CSNK2A10.33043118
92MKNK20.32783967
93PRKCI0.32426219
94PIK3CA0.32070534
95EIF2AK20.31884747
96SCYL20.29309457
97MKNK10.27402100
98ILK0.27138962
99WEE10.26254588
100CAMK2D0.26085802

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.88105447
2Oxidative phosphorylation_Homo sapiens_hsa001904.03285680
3Protein export_Homo sapiens_hsa030603.43089709
4Parkinsons disease_Homo sapiens_hsa050123.29881000
5Primary immunodeficiency_Homo sapiens_hsa053402.78235404
6RNA polymerase_Homo sapiens_hsa030202.38747103
7Alzheimers disease_Homo sapiens_hsa050102.24638249
8Autoimmune thyroid disease_Homo sapiens_hsa053202.10783559
9Graft-versus-host disease_Homo sapiens_hsa053322.06569064
10Type I diabetes mellitus_Homo sapiens_hsa049402.03919593
11Huntingtons disease_Homo sapiens_hsa050162.01626919
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98237717
13Allograft rejection_Homo sapiens_hsa053301.97720668
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88938678
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85166383
16Sulfur metabolism_Homo sapiens_hsa009201.75513954
17Antigen processing and presentation_Homo sapiens_hsa046121.73058054
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72019516
19Phototransduction_Homo sapiens_hsa047441.58559321
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.54295493
21Asthma_Homo sapiens_hsa053101.54277919
22Ribosome_Homo sapiens_hsa030101.53414063
23Rheumatoid arthritis_Homo sapiens_hsa053231.49395471
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48497821
25Cardiac muscle contraction_Homo sapiens_hsa042601.47972684
26Hematopoietic cell lineage_Homo sapiens_hsa046401.33120543
27Collecting duct acid secretion_Homo sapiens_hsa049661.31584273
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.28529672
29Fatty acid elongation_Homo sapiens_hsa000621.28360636
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25639332
31RNA degradation_Homo sapiens_hsa030181.25514638
32Homologous recombination_Homo sapiens_hsa034401.18566103
33Basal transcription factors_Homo sapiens_hsa030221.14685797
34Propanoate metabolism_Homo sapiens_hsa006401.13239054
35Peroxisome_Homo sapiens_hsa041461.12696258
36Nitrogen metabolism_Homo sapiens_hsa009101.10344776
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04414561
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03920527
39Pyrimidine metabolism_Homo sapiens_hsa002401.03418874
40Mismatch repair_Homo sapiens_hsa034300.98552366
41Butanoate metabolism_Homo sapiens_hsa006500.97079018
42Purine metabolism_Homo sapiens_hsa002300.95639540
43Linoleic acid metabolism_Homo sapiens_hsa005910.91412708
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84679293
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83798663
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83382876
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82810599
48One carbon pool by folate_Homo sapiens_hsa006700.82596955
49Chemical carcinogenesis_Homo sapiens_hsa052040.81454388
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79771909
51Fanconi anemia pathway_Homo sapiens_hsa034600.79549970
52Nucleotide excision repair_Homo sapiens_hsa034200.79017668
53Tryptophan metabolism_Homo sapiens_hsa003800.76718464
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75758351
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74394079
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73693784
57Regulation of autophagy_Homo sapiens_hsa041400.73220283
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71937259
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71889940
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68909546
61Glutathione metabolism_Homo sapiens_hsa004800.68690083
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68291343
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68202179
64Steroid biosynthesis_Homo sapiens_hsa001000.67485175
65Metabolic pathways_Homo sapiens_hsa011000.65896003
66Selenocompound metabolism_Homo sapiens_hsa004500.65716626
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65201312
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63755908
69N-Glycan biosynthesis_Homo sapiens_hsa005100.62179744
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61449209
71Ether lipid metabolism_Homo sapiens_hsa005650.60997650
72Caffeine metabolism_Homo sapiens_hsa002320.60843465
73Folate biosynthesis_Homo sapiens_hsa007900.60256705
74Retinol metabolism_Homo sapiens_hsa008300.58605978
75Viral myocarditis_Homo sapiens_hsa054160.58238259
76Base excision repair_Homo sapiens_hsa034100.57538520
77Non-homologous end-joining_Homo sapiens_hsa034500.56422128
78T cell receptor signaling pathway_Homo sapiens_hsa046600.56189792
79DNA replication_Homo sapiens_hsa030300.55357416
80Arachidonic acid metabolism_Homo sapiens_hsa005900.55342772
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.54679057
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50347952
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48633162
84RNA transport_Homo sapiens_hsa030130.47569344
85Spliceosome_Homo sapiens_hsa030400.45711867
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44496214
87Shigellosis_Homo sapiens_hsa051310.43694490
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40323207
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.39183936
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.36975389
91Salmonella infection_Homo sapiens_hsa051320.35559618
92Olfactory transduction_Homo sapiens_hsa047400.35522906
93Systemic lupus erythematosus_Homo sapiens_hsa053220.34275334
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32491348
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30377943
96Mineral absorption_Homo sapiens_hsa049780.29556210
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28632619
98Nicotine addiction_Homo sapiens_hsa050330.26741681
99Vibrio cholerae infection_Homo sapiens_hsa051100.26454508
100Pyruvate metabolism_Homo sapiens_hsa006200.25975040

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