FKBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.64548863
2ATP synthesis coupled proton transport (GO:0015986)6.10551533
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.10551533
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.09647983
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.98970790
6respiratory electron transport chain (GO:0022904)4.60521473
7electron transport chain (GO:0022900)4.51135931
8cullin deneddylation (GO:0010388)4.41109527
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.18488581
10NADH dehydrogenase complex assembly (GO:0010257)4.18488581
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18488581
12chaperone-mediated protein transport (GO:0072321)4.09106426
13establishment of integrated proviral latency (GO:0075713)4.07805611
14protein deneddylation (GO:0000338)4.04802727
15protein complex biogenesis (GO:0070271)4.00758821
16DNA double-strand break processing (GO:0000729)3.98488423
17maturation of SSU-rRNA (GO:0030490)3.93900068
18oxidative phosphorylation (GO:0006119)3.91495822
19proteasome assembly (GO:0043248)3.90186113
20protein neddylation (GO:0045116)3.85465993
21ribosomal small subunit assembly (GO:0000028)3.83563415
22mitochondrial respiratory chain complex assembly (GO:0033108)3.79814755
23ribosomal small subunit biogenesis (GO:0042274)3.77156365
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71846319
25CENP-A containing nucleosome assembly (GO:0034080)3.54234216
26chromatin remodeling at centromere (GO:0031055)3.46258753
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45458736
28viral transcription (GO:0019083)3.44213006
29translational termination (GO:0006415)3.41628083
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39794605
31negative regulation of ligase activity (GO:0051352)3.39291286
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39291286
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36124019
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35568301
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35048555
367-methylguanosine mRNA capping (GO:0006370)3.34749131
37regulation of cellular amino acid metabolic process (GO:0006521)3.34134607
38formation of translation preinitiation complex (GO:0001731)3.33860280
39GTP biosynthetic process (GO:0006183)3.33133876
407-methylguanosine RNA capping (GO:0009452)3.32326084
41RNA capping (GO:0036260)3.32326084
42establishment of protein localization to mitochondrion (GO:0072655)3.25797344
43regulation of mitochondrial translation (GO:0070129)3.25766483
44respiratory chain complex IV assembly (GO:0008535)3.25179360
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22454913
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.21486532
47establishment of viral latency (GO:0019043)3.20436117
48ribosomal large subunit biogenesis (GO:0042273)3.18963187
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.18186694
50termination of RNA polymerase III transcription (GO:0006386)3.18186694
51ATP biosynthetic process (GO:0006754)3.18158719
52protein targeting to mitochondrion (GO:0006626)3.16440326
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16429640
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16429640
55nucleobase biosynthetic process (GO:0046112)3.16232668
56inner mitochondrial membrane organization (GO:0007007)3.14603781
57purine nucleoside triphosphate biosynthetic process (GO:0009145)3.13959815
58purine nucleobase biosynthetic process (GO:0009113)3.13408973
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13145635
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13145635
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13145635
62histone arginine methylation (GO:0034969)3.10481263
63viral mRNA export from host cell nucleus (GO:0046784)3.10351849
64spliceosomal snRNP assembly (GO:0000387)3.09626564
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09593170
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09593170
67UTP biosynthetic process (GO:0006228)3.08991790
68signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08926231
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.08926231
70DNA strand elongation involved in DNA replication (GO:0006271)3.08554041
71translational elongation (GO:0006414)3.08188996
72guanosine-containing compound biosynthetic process (GO:1901070)3.07872858
73cellular component biogenesis (GO:0044085)3.07771212
74telomere maintenance via semi-conservative replication (GO:0032201)3.07711992
75protein localization to mitochondrion (GO:0070585)3.07512438
76regulation of helicase activity (GO:0051095)3.06200848
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.05748221
78regulation of mitotic spindle checkpoint (GO:1903504)3.05048825
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05048825
80ribonucleoprotein complex biogenesis (GO:0022613)3.04742362
81kinetochore organization (GO:0051383)3.02755761
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00203834
83DNA replication initiation (GO:0006270)3.00111646
84kinetochore assembly (GO:0051382)2.99784240
85translational initiation (GO:0006413)2.98504421
86cotranslational protein targeting to membrane (GO:0006613)2.97550947
87DNA strand elongation (GO:0022616)2.96691808
88translation (GO:0006412)2.96106093
89DNA ligation (GO:0006266)2.94582305
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.94544790
91cellular protein complex disassembly (GO:0043624)2.94082970
92DNA damage response, detection of DNA damage (GO:0042769)2.93987669
93spliceosomal complex assembly (GO:0000245)2.93857538
94histone mRNA metabolic process (GO:0008334)2.93833540
95transcription-coupled nucleotide-excision repair (GO:0006283)2.93513835
96SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92969779
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.90868617
98protein targeting to ER (GO:0045047)2.88473217
99cytochrome complex assembly (GO:0017004)2.88248381
100DNA catabolic process, exonucleolytic (GO:0000738)2.87905750
101DNA replication-independent nucleosome assembly (GO:0006336)2.87609451
102DNA replication-independent nucleosome organization (GO:0034724)2.87609451
103positive regulation of ligase activity (GO:0051351)2.84968794
104DNA replication-dependent nucleosome assembly (GO:0006335)2.84850327
105DNA replication-dependent nucleosome organization (GO:0034723)2.84850327
106pseudouridine synthesis (GO:0001522)2.83477015
107replication fork processing (GO:0031297)2.82777520
108histone exchange (GO:0043486)2.82726126
109water-soluble vitamin biosynthetic process (GO:0042364)2.82029336
110peptidyl-arginine omega-N-methylation (GO:0035247)2.81827286
111DNA replication checkpoint (GO:0000076)2.80246115
112IMP biosynthetic process (GO:0006188)2.78245626
113L-serine metabolic process (GO:0006563)2.77809201
114DNA unwinding involved in DNA replication (GO:0006268)2.77701256
115protein localization to kinetochore (GO:0034501)2.76897510
116rRNA processing (GO:0006364)2.76717564
117hydrogen ion transmembrane transport (GO:1902600)2.76557221
118protein localization to endoplasmic reticulum (GO:0070972)2.76469001
119telomere maintenance via recombination (GO:0000722)2.76428571
120protein-cofactor linkage (GO:0018065)2.75494011
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71901954
122mitotic metaphase plate congression (GO:0007080)2.71673627
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.71174505
124mitotic recombination (GO:0006312)2.70410647
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70019230
126rRNA modification (GO:0000154)2.65872794
127IMP metabolic process (GO:0046040)2.63365652
128intracellular protein transmembrane import (GO:0044743)2.61820137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.70312608
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26931963
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.15143961
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.76076665
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.57907088
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.51988659
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.30850506
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.14448297
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.08671632
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03398571
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.94095225
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92902117
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83471118
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82692709
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80601983
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71996471
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69790911
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57418661
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56087683
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.51643657
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36763399
22VDR_23849224_ChIP-Seq_CD4+_Human2.26315611
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19757360
24* XRN2_22483619_ChIP-Seq_HELA_Human2.15722672
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.13122365
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07515709
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07379709
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07112276
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05933594
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05890531
31TTF2_22483619_ChIP-Seq_HELA_Human2.04177439
32ELK1_19687146_ChIP-ChIP_HELA_Human2.02356472
33DCP1A_22483619_ChIP-Seq_HELA_Human2.01356596
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.98603624
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.94167926
36ZNF274_21170338_ChIP-Seq_K562_Hela1.92181869
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82754529
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82127900
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.78758097
40EZH2_22144423_ChIP-Seq_EOC_Human1.74571584
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70833266
42FUS_26573619_Chip-Seq_HEK293_Human1.68141678
43GABP_19822575_ChIP-Seq_HepG2_Human1.67767694
44IGF1R_20145208_ChIP-Seq_DFB_Human1.67339846
45* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66874639
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65784014
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65369484
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63923921
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57881784
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57746636
51* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47647220
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.41244179
53* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40059253
54TAF15_26573619_Chip-Seq_HEK293_Human1.38159292
55MYC_18940864_ChIP-ChIP_HL60_Human1.37436242
56* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37008275
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35815831
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34989067
59* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34886664
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32379372
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31531117
62P300_19829295_ChIP-Seq_ESCs_Human1.27316724
63VDR_22108803_ChIP-Seq_LS180_Human1.26315013
64EWS_26573619_Chip-Seq_HEK293_Human1.25687727
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24219964
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.24091414
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20455456
68* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14175990
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.13847614
70AR_21909140_ChIP-Seq_LNCAP_Human1.13361709
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12677969
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11849341
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09138344
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08358229
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07215565
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.06111129
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05312805
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.04313643
79IRF1_19129219_ChIP-ChIP_H3396_Human1.04169957
80CIITA_25753668_ChIP-Seq_RAJI_Human1.03755231
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03019133
82* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01775833
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00272578
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99232374
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97644317
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96143667
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94776094
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94129456
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93217572
90SALL1_21062744_ChIP-ChIP_HESCs_Human0.92727439
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92103786
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90568379
93* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89424159
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88859000
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88005604
96TP53_22573176_ChIP-Seq_HFKS_Human0.86312394
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85290536
98RNF2_27304074_Chip-Seq_NSC_Mouse0.85022907
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.84744467
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84341107
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83797433
102NANOG_16153702_ChIP-ChIP_HESCs_Human0.83146839
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82988034
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.82037505
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81891705
106GBX2_23144817_ChIP-Seq_PC3_Human0.81356477
107* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81077641
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80955837
109KDM5A_27292631_Chip-Seq_BREAST_Human0.80646773
110CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80540786
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79478950
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79457503
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.79122084
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77720287
115SOX2_19829295_ChIP-Seq_ESCs_Human0.77408262
116NANOG_19829295_ChIP-Seq_ESCs_Human0.77408262
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77291557
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.77118252
119* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76856968
120HTT_18923047_ChIP-ChIP_STHdh_Human0.76402115
121SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75670883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.44399334
2MP0001529_abnormal_vocalization3.09564490
3MP0003123_paternal_imprinting3.00872135
4MP0003122_maternal_imprinting2.70110162
5MP0004957_abnormal_blastocyst_morpholog2.62830391
6MP0003121_genomic_imprinting2.42697843
7MP0006276_abnormal_autonomic_nervous2.40332497
8MP0010094_abnormal_chromosome_stability2.38763601
9MP0008877_abnormal_DNA_methylation2.27916637
10MP0003693_abnormal_embryo_hatching2.26812877
11MP0008057_abnormal_DNA_replication2.22849201
12MP0009379_abnormal_foot_pigmentation2.10391683
13MP0001293_anophthalmia2.02994529
14MP0008058_abnormal_DNA_repair1.98477960
15MP0002837_dystrophic_cardiac_calcinosis1.90171657
16MP0003077_abnormal_cell_cycle1.88699004
17MP0006292_abnormal_olfactory_placode1.86662870
18MP0003787_abnormal_imprinting1.85996344
19MP0001968_abnormal_touch/_nociception1.83315424
20MP0001905_abnormal_dopamine_level1.80657595
21MP0008932_abnormal_embryonic_tissue1.78842240
22MP0002736_abnormal_nociception_after1.76352066
23MP0009046_muscle_twitch1.75851661
24MP0001188_hyperpigmentation1.74404072
25MP0003635_abnormal_synaptic_transmissio1.72028499
26MP0006035_abnormal_mitochondrial_morpho1.71993293
27MP0009745_abnormal_behavioral_response1.70890117
28MP0003111_abnormal_nucleus_morphology1.69314804
29MP0004859_abnormal_synaptic_plasticity1.54798245
30MP0004133_heterotaxia1.53992779
31MP0004215_abnormal_myocardial_fiber1.53895403
32MP0004145_abnormal_muscle_electrophysio1.52057998
33MP0006036_abnormal_mitochondrial_physio1.51611898
34MP0002735_abnormal_chemical_nociception1.50541770
35MP0004142_abnormal_muscle_tone1.49844160
36MP0002064_seizures1.48898189
37MP0000751_myopathy1.48568384
38MP0002272_abnormal_nervous_system1.48414348
39MP0002572_abnormal_emotion/affect_behav1.45910615
40MP0002063_abnormal_learning/memory/cond1.42235069
41MP0002734_abnormal_mechanical_nocicepti1.41578067
42MP0003011_delayed_dark_adaptation1.38469690
43MP0001440_abnormal_grooming_behavior1.37992599
44MP0004084_abnormal_cardiac_muscle1.35195208
45MP0008789_abnormal_olfactory_epithelium1.32508186
46MP0003937_abnormal_limbs/digits/tail_de1.32025456
47MP0002751_abnormal_autonomic_nervous1.30563311
48MP0002234_abnormal_pharynx_morphology1.30270389
49MP0003315_abnormal_perineum_morphology1.30145073
50MP0005499_abnormal_olfactory_system1.28124854
51MP0005394_taste/olfaction_phenotype1.28124854
52MP0003186_abnormal_redox_activity1.27934835
53MP0006072_abnormal_retinal_apoptosis1.27837191
54MP0002163_abnormal_gland_morphology1.27137762
55MP0005386_behavior/neurological_phenoty1.25922947
56MP0004924_abnormal_behavior1.25922947
57MP0003646_muscle_fatigue1.23721401
58MP0002638_abnormal_pupillary_reflex1.21927644
59MP0002233_abnormal_nose_morphology1.21847532
60MP0002184_abnormal_innervation1.19959504
61MP0002067_abnormal_sensory_capabilities1.19816600
62MP0004270_analgesia1.19400224
63MP0004036_abnormal_muscle_relaxation1.17859176
64MP0005084_abnormal_gallbladder_morpholo1.17069466
65MP0001984_abnormal_olfaction1.15705883
66MP0001286_abnormal_eye_development1.15377052
67MP0005423_abnormal_somatic_nervous1.15179359
68MP0008007_abnormal_cellular_replicative1.14954287
69MP0005253_abnormal_eye_physiology1.12146100
70MP0003786_premature_aging1.11535003
71MP0003806_abnormal_nucleotide_metabolis1.09090366
72MP0005551_abnormal_eye_electrophysiolog1.08859102
73MP0002102_abnormal_ear_morphology1.07673231
74MP0001986_abnormal_taste_sensitivity1.05409376
75MP0000566_synostosis1.04549696
76MP0002160_abnormal_reproductive_system1.04088994
77MP0004147_increased_porphyrin_level1.03848933
78MP0001486_abnormal_startle_reflex1.03493323
79MP0000778_abnormal_nervous_system1.03306809
80MP0003136_yellow_coat_color1.02814944
81MP0002697_abnormal_eye_size1.02615232
82MP0001970_abnormal_pain_threshold1.02154075
83MP0008995_early_reproductive_senescence1.01733817
84MP0002210_abnormal_sex_determination1.00355154
85MP0003938_abnormal_ear_development0.99292830
86MP0002733_abnormal_thermal_nociception0.98917053
87MP0000631_abnormal_neuroendocrine_gland0.98498816
88MP0004233_abnormal_muscle_weight0.98037359
89MP0002557_abnormal_social/conspecific_i0.97854297
90MP0000749_muscle_degeneration0.97314574
91MP0003137_abnormal_impulse_conducting0.95004297
92MP0005187_abnormal_penis_morphology0.94381114
93MP0000647_abnormal_sebaceous_gland0.92068975
94MP0002938_white_spotting0.92065300
95MP0010030_abnormal_orbit_morphology0.91327317
96MP0002127_abnormal_cardiovascular_syste0.91113337
97MP0003890_abnormal_embryonic-extraembry0.90114300
98MP0000049_abnormal_middle_ear0.88520187
99MP0005646_abnormal_pituitary_gland0.88226887
100MP0009697_abnormal_copulation0.88087930
101MP0001730_embryonic_growth_arrest0.87795505
102MP0002822_catalepsy0.87792717
103MP0009672_abnormal_birth_weight0.87125662
104MP0001177_atelectasis0.86404604
105MP0002332_abnormal_exercise_endurance0.85929818
106MP0005391_vision/eye_phenotype0.85606513
107MP0002090_abnormal_vision0.85514473
108MP0001145_abnormal_male_reproductive0.85393282
109MP0000350_abnormal_cell_proliferation0.85292578
110MP0003755_abnormal_palate_morphology0.84896187
111MP0003718_maternal_effect0.84598032
112MP0001501_abnormal_sleep_pattern0.84268838
113MP0000653_abnormal_sex_gland0.83419825
114MP0002085_abnormal_embryonic_tissue0.83340417
115MP0000372_irregular_coat_pigmentation0.83225826
116MP0003861_abnormal_nervous_system0.82833471
117MP0003941_abnormal_skin_development0.82821283
118MP0001299_abnormal_eye_distance/0.81124589
119MP0005266_abnormal_metabolism0.81116554
120MP0001929_abnormal_gametogenesis0.80854212
121MP0008872_abnormal_physiological_respon0.80636157
122MP0003119_abnormal_digestive_system0.80221196
123MP0001485_abnormal_pinna_reflex0.79667877
124MP0001697_abnormal_embryo_size0.79289001
125MP0004085_abnormal_heartbeat0.78735556
126MP0002084_abnormal_developmental_patter0.78407139
127MP0002653_abnormal_ependyma_morphology0.78182219
128MP0001346_abnormal_lacrimal_gland0.78134355
129MP0003567_abnormal_fetal_cardiomyocyte0.76758373
130MP0004484_altered_response_of0.76500310
131MP0005379_endocrine/exocrine_gland_phen0.73761826
132MP0002752_abnormal_somatic_nervous0.73513871

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.25722923
2Abnormal mitochondria in muscle tissue (HP:0008316)5.76453920
3Mitochondrial inheritance (HP:0001427)5.24204130
4Progressive macrocephaly (HP:0004481)5.21674951
5Acute encephalopathy (HP:0006846)4.74012903
6Increased CSF lactate (HP:0002490)4.68351809
7Hepatocellular necrosis (HP:0001404)4.31201478
8Abnormality of glycolysis (HP:0004366)3.73287319
9Increased serum pyruvate (HP:0003542)3.73287319
10Increased hepatocellular lipid droplets (HP:0006565)3.69501078
11Exercise intolerance (HP:0003546)3.48690414
12Hepatic necrosis (HP:0002605)3.41646247
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.20682468
14Birth length less than 3rd percentile (HP:0003561)3.19706219
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13755324
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13755324
17Lipid accumulation in hepatocytes (HP:0006561)3.10904554
18Increased serum lactate (HP:0002151)3.07887137
19Cerebral edema (HP:0002181)3.07158954
20Optic disc pallor (HP:0000543)3.06031760
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.03782126
22Leukodystrophy (HP:0002415)3.00765926
23Lactic acidosis (HP:0003128)2.99273816
24Respiratory failure (HP:0002878)2.97039304
25Abnormality of the labia minora (HP:0012880)2.94190484
26Focal motor seizures (HP:0011153)2.86692299
27Septo-optic dysplasia (HP:0100842)2.81718565
28Abnormality of cells of the erythroid lineage (HP:0012130)2.72990670
29Increased intramyocellular lipid droplets (HP:0012240)2.65593146
30Hyperglycinemia (HP:0002154)2.62983142
31Renal Fanconi syndrome (HP:0001994)2.60816774
32Meckel diverticulum (HP:0002245)2.55448489
33Methylmalonic acidemia (HP:0002912)2.47218829
34Gait imbalance (HP:0002141)2.43095533
35Abnormal number of erythroid precursors (HP:0012131)2.41368276
36Congenital primary aphakia (HP:0007707)2.40927411
37Abnormality of the ileum (HP:0001549)2.40402071
383-Methylglutaconic aciduria (HP:0003535)2.36430790
39Medial flaring of the eyebrow (HP:0010747)2.35698498
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.35345982
41Emotional lability (HP:0000712)2.32292024
42Respiratory difficulties (HP:0002880)2.32163910
43Cerebral hypomyelination (HP:0006808)2.31249150
44Abnormal hair whorl (HP:0010721)2.31231081
45Reticulocytopenia (HP:0001896)2.28661649
46Atonic seizures (HP:0010819)2.27653834
47Nephrogenic diabetes insipidus (HP:0009806)2.27499454
48Oral leukoplakia (HP:0002745)2.26798258
49Congenital, generalized hypertrichosis (HP:0004540)2.24871613
50Breast hypoplasia (HP:0003187)2.21731589
51Colon cancer (HP:0003003)2.21550609
52Abnormality of chromosome stability (HP:0003220)2.21193823
53Abnormality of serum amino acid levels (HP:0003112)2.21127872
54Exertional dyspnea (HP:0002875)2.16483153
55Unsteady gait (HP:0002317)2.14416632
56Aplastic anemia (HP:0001915)2.13753341
57Hyperglycinuria (HP:0003108)2.13222583
58Macrocytic anemia (HP:0001972)2.12354512
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12019513
60Abnormality of alanine metabolism (HP:0010916)2.12019513
61Hyperalaninemia (HP:0003348)2.12019513
62Absent septum pellucidum (HP:0001331)2.11667086
63Microvesicular hepatic steatosis (HP:0001414)2.09825229
64Abnormality of midbrain morphology (HP:0002418)2.07782765
65Molar tooth sign on MRI (HP:0002419)2.07782765
66Neuroendocrine neoplasm (HP:0100634)2.07246268
67Supernumerary spleens (HP:0009799)2.05750622
68Triphalangeal thumb (HP:0001199)2.05525770
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04360343
70Chromsome breakage (HP:0040012)2.02878471
71X-linked dominant inheritance (HP:0001423)2.02852033
72Abnormality of glycine metabolism (HP:0010895)2.01753087
73Abnormality of serine family amino acid metabolism (HP:0010894)2.01753087
74Methylmalonic aciduria (HP:0012120)2.01585274
75Increased muscle lipid content (HP:0009058)1.99665384
76Nephronophthisis (HP:0000090)1.99013215
77Myokymia (HP:0002411)1.98971786
78Lethargy (HP:0001254)1.97790625
79Exercise-induced muscle cramps (HP:0003710)1.97323182
80Pheochromocytoma (HP:0002666)1.94954123
81Rimmed vacuoles (HP:0003805)1.93704013
82Volvulus (HP:0002580)1.90297534
83Absence seizures (HP:0002121)1.90245406
84Abnormality of the preputium (HP:0100587)1.89902615
85Genital tract atresia (HP:0001827)1.88663856
86Abnormality of methionine metabolism (HP:0010901)1.86821664
87Nemaline bodies (HP:0003798)1.86684508
88Vaginal atresia (HP:0000148)1.86448035
89CNS demyelination (HP:0007305)1.86087543
90Limb dystonia (HP:0002451)1.84848564
91Optic nerve hypoplasia (HP:0000609)1.84724242
92Abnormal lung lobation (HP:0002101)1.83712602
93Poor coordination (HP:0002370)1.83080510
94Progressive external ophthalmoplegia (HP:0000590)1.82892369
95Abnormality of the septum pellucidum (HP:0007375)1.82665896
96Carpal bone hypoplasia (HP:0001498)1.82430548
97Pancreatic fibrosis (HP:0100732)1.82250306
98Abnormality of renal resorption (HP:0011038)1.82227512
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82158917
100Abnormality of the anterior horn cell (HP:0006802)1.81502721
101Degeneration of anterior horn cells (HP:0002398)1.81502721
102Abnormal number of incisors (HP:0011064)1.80805171
103Sclerocornea (HP:0000647)1.77943565
104Shoulder girdle muscle weakness (HP:0003547)1.77473407
105Muscle fiber inclusion bodies (HP:0100299)1.76766520
106Maternal diabetes (HP:0009800)1.75333420
107CNS hypomyelination (HP:0003429)1.74697004
108Megaloblastic anemia (HP:0001889)1.74029365
109Hypothermia (HP:0002045)1.73423252
110Patellar aplasia (HP:0006443)1.73138997
111Pallor (HP:0000980)1.72625876
112Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72184091
113Small intestinal stenosis (HP:0012848)1.70985919
114Duodenal stenosis (HP:0100867)1.70985919
115Febrile seizures (HP:0002373)1.70732208
116Visual hallucinations (HP:0002367)1.70697711
117Poor suck (HP:0002033)1.69935598
118Anophthalmia (HP:0000528)1.69701840
119Epileptic encephalopathy (HP:0200134)1.69612468
120Neuroblastic tumors (HP:0004376)1.69115477
121Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.69115477
122Neuroblastoma (HP:0003006)1.69115477
123Primitive neuroectodermal tumor (HP:0030065)1.69115477
124Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.67859539
125Type I transferrin isoform profile (HP:0003642)1.67772690
126Dialeptic seizures (HP:0011146)1.67403496
127Severe visual impairment (HP:0001141)1.67330091
128Pendular nystagmus (HP:0012043)1.66994636
129Abnormality of the duodenum (HP:0002246)1.66457900
130Abnormality of placental membranes (HP:0011409)1.66326703
131Amniotic constriction ring (HP:0009775)1.66326703
132Muscle hypertrophy of the lower extremities (HP:0008968)1.64963481
133Intestinal atresia (HP:0011100)1.63519203
134Aplasia/Hypoplasia of the patella (HP:0006498)1.63462690
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.63263318
136Rough bone trabeculation (HP:0100670)1.61712987
137Postnatal microcephaly (HP:0005484)1.61007775
138Nephroblastoma (Wilms tumor) (HP:0002667)1.56841670
139Calf muscle hypertrophy (HP:0008981)1.54799694
140Embryonal renal neoplasm (HP:0011794)1.53946874
141Delusions (HP:0000746)1.53935394
142Pancreatic cysts (HP:0001737)1.53915816
143Ragged-red muscle fibers (HP:0003200)1.53200786
144True hermaphroditism (HP:0010459)1.53080903
145Medulloblastoma (HP:0002885)1.52596394
146Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.51999506
147Stenosis of the external auditory canal (HP:0000402)1.50189657
148Horseshoe kidney (HP:0000085)1.50042344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.59869295
2MAP3K123.37537841
3WEE13.26913508
4BUB13.18164432
5PNCK2.70894562
6NME12.69177387
7SRPK12.58849472
8CDC72.50663475
9TSSK62.49961619
10STK162.45803170
11EIF2AK12.44760643
12CASK2.15724634
13NEK12.06390865
14NUAK12.02557083
15VRK11.99693008
16TRIM281.93620534
17MAP2K71.86558043
18MKNK11.85619414
19MAP3K41.83442012
20TAF11.73736932
21EIF2AK31.69500148
22CCNB11.69021013
23PLK21.67824265
24PLK31.64076675
25MAP4K21.63977985
26CDK191.56860992
27PLK41.54838062
28MYLK1.47225556
29MKNK21.43107039
30BRSK21.43004797
31NTRK31.42726920
32BCR1.34436143
33OBSCN1.32622650
34MINK11.30673718
35ACVR1B1.28744844
36PLK11.24403854
37CDK81.23115447
38ARAF1.22837415
39DAPK11.18909748
40NME21.16565387
41CSNK1G11.14112382
42BRSK11.10520832
43AURKA1.10205384
44BCKDK1.07811902
45PDK41.04924291
46PDK31.04924291
47MAPK131.04566033
48BRAF1.02114280
49ADRBK21.01122640
50MARK11.00263870
51TLK10.96631212
52AKT30.94455898
53GRK70.94360442
54PINK10.93399622
55TNIK0.93137696
56PBK0.92268600
57ZAK0.88879852
58MST40.87781810
59CSNK1A1L0.84949667
60MAP2K40.83770033
61GRK50.83594384
62LIMK10.83043136
63DYRK20.82222820
64EIF2AK20.80526619
65TTK0.77820183
66SIK30.76666187
67AURKB0.75222618
68GRK10.75140616
69PASK0.74803230
70MUSK0.72784124
71CSNK2A20.72441132
72EPHA40.69195764
73CSNK1G30.67343239
74RPS6KB20.67098154
75CDK180.66973764
76CDK140.66167825
77CSNK2A10.65027367
78ATR0.64787819
79PRKCG0.64708714
80MAP3K90.63462487
81CHEK20.62709286
82UHMK10.62348430
83CDK70.61406780
84ADRBK10.61400778
85BMPR1B0.60008546
86NEK20.59775923
87CDK150.58638383
88INSRR0.58425155
89CDK11A0.57531408
90KSR10.56253210
91RPS6KA40.53923838
92ERBB30.53502027
93CAMK2A0.52160755
94CHEK10.50276558
95STK38L0.49439322
96CDK30.48718655
97CAMK2B0.48561339
98WNK30.47835321
99PDK20.46635023
100TGFBR10.46588421
101CSNK1E0.46088407
102PHKG10.45790861
103PHKG20.45790861
104STK390.43546405
105CSNK1A10.42525755
106STK240.42154854
107TESK20.41185496
108WNK40.41154888
109BMPR20.40789404
110PRKCI0.40544582
111DYRK30.40502492
112PRKDC0.39764082
113OXSR10.39754464
114CDK10.39568878
115YES10.39195305
116ATM0.38912168
117CAMK2D0.37901607
118TIE10.37689973
119MAPKAPK50.36513542
120PRKCE0.36504950
121NTRK20.36238639
122STK30.36165324
123CSNK1G20.35608117
124PAK30.34275339

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.56869484
2Proteasome_Homo sapiens_hsa030504.24484412
3Parkinsons disease_Homo sapiens_hsa050124.10405081
4Ribosome_Homo sapiens_hsa030103.73493731
5Huntingtons disease_Homo sapiens_hsa050163.14607699
6Mismatch repair_Homo sapiens_hsa034303.10382818
7RNA polymerase_Homo sapiens_hsa030203.07725572
8DNA replication_Homo sapiens_hsa030302.99031521
9Alzheimers disease_Homo sapiens_hsa050102.93930500
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52393670
11Spliceosome_Homo sapiens_hsa030402.50633178
12Cardiac muscle contraction_Homo sapiens_hsa042602.21423010
13Nucleotide excision repair_Homo sapiens_hsa034202.18936664
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09274130
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06320311
16RNA transport_Homo sapiens_hsa030132.04924342
17Pyrimidine metabolism_Homo sapiens_hsa002401.90199803
18Propanoate metabolism_Homo sapiens_hsa006401.88628635
19Homologous recombination_Homo sapiens_hsa034401.88333294
20Nicotine addiction_Homo sapiens_hsa050331.84856158
21Collecting duct acid secretion_Homo sapiens_hsa049661.68017278
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63090391
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60991170
24RNA degradation_Homo sapiens_hsa030181.51486402
25Base excision repair_Homo sapiens_hsa034101.51328681
26Protein export_Homo sapiens_hsa030601.49894311
27Synaptic vesicle cycle_Homo sapiens_hsa047211.45372055
28Basal transcription factors_Homo sapiens_hsa030221.44364828
29Cell cycle_Homo sapiens_hsa041101.42506745
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38516540
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33728382
32Steroid biosynthesis_Homo sapiens_hsa001001.32727249
33Non-homologous end-joining_Homo sapiens_hsa034501.32170821
34Purine metabolism_Homo sapiens_hsa002301.25739110
35Fanconi anemia pathway_Homo sapiens_hsa034601.21776646
36Folate biosynthesis_Homo sapiens_hsa007901.20458610
37Oocyte meiosis_Homo sapiens_hsa041141.16347707
38Vibrio cholerae infection_Homo sapiens_hsa051101.06114092
39mRNA surveillance pathway_Homo sapiens_hsa030151.03125368
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00973600
41Butanoate metabolism_Homo sapiens_hsa006500.98072819
42Vitamin B6 metabolism_Homo sapiens_hsa007500.83483606
43Taste transduction_Homo sapiens_hsa047420.83198994
44One carbon pool by folate_Homo sapiens_hsa006700.83116938
45Amphetamine addiction_Homo sapiens_hsa050310.82128287
46Serotonergic synapse_Homo sapiens_hsa047260.79809782
47GABAergic synapse_Homo sapiens_hsa047270.79171461
48Long-term potentiation_Homo sapiens_hsa047200.77208341
49Peroxisome_Homo sapiens_hsa041460.76967359
50Selenocompound metabolism_Homo sapiens_hsa004500.76081996
51Pyruvate metabolism_Homo sapiens_hsa006200.74823642
52Epstein-Barr virus infection_Homo sapiens_hsa051690.74016401
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73966623
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73274526
55Dopaminergic synapse_Homo sapiens_hsa047280.73137711
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72701450
57Olfactory transduction_Homo sapiens_hsa047400.70001356
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69712651
59Phototransduction_Homo sapiens_hsa047440.69690587
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69375721
61Morphine addiction_Homo sapiens_hsa050320.68073396
62Fatty acid degradation_Homo sapiens_hsa000710.68043701
63Circadian entrainment_Homo sapiens_hsa047130.67936904
64Alcoholism_Homo sapiens_hsa050340.67625637
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67061124
66Arginine and proline metabolism_Homo sapiens_hsa003300.66956230
67beta-Alanine metabolism_Homo sapiens_hsa004100.65761387
68Carbon metabolism_Homo sapiens_hsa012000.62344865
69Fatty acid metabolism_Homo sapiens_hsa012120.61202655
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60543489
71Basal cell carcinoma_Homo sapiens_hsa052170.59688213
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.56975110
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56901077
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56239697
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55256826
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55128297
77Calcium signaling pathway_Homo sapiens_hsa040200.54893737
78Tryptophan metabolism_Homo sapiens_hsa003800.54043953
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50782015
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50404244
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49566789
82Glutamatergic synapse_Homo sapiens_hsa047240.49562091
83Metabolic pathways_Homo sapiens_hsa011000.48666253
84Biosynthesis of amino acids_Homo sapiens_hsa012300.48051299
85Long-term depression_Homo sapiens_hsa047300.44144167
86Sulfur relay system_Homo sapiens_hsa041220.43187851
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41604295
88Systemic lupus erythematosus_Homo sapiens_hsa053220.41203592
89Nitrogen metabolism_Homo sapiens_hsa009100.40114944
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39083149
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38268863
92Retinol metabolism_Homo sapiens_hsa008300.37773979
93Vitamin digestion and absorption_Homo sapiens_hsa049770.37768864
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.37693135
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37044792
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36690178
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36502808
98p53 signaling pathway_Homo sapiens_hsa041150.36120732
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35362290
100Regulation of autophagy_Homo sapiens_hsa041400.35191995
101Chemical carcinogenesis_Homo sapiens_hsa052040.35053582
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.35033105
103Renin secretion_Homo sapiens_hsa049240.32544718
104Sulfur metabolism_Homo sapiens_hsa009200.31449467
105Oxytocin signaling pathway_Homo sapiens_hsa049210.31238840
106Gap junction_Homo sapiens_hsa045400.30761075
107Hippo signaling pathway_Homo sapiens_hsa043900.29928305
108Fructose and mannose metabolism_Homo sapiens_hsa000510.28218860
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27477931
110Cholinergic synapse_Homo sapiens_hsa047250.25909953
111Type I diabetes mellitus_Homo sapiens_hsa049400.25198550
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25130271
113Cocaine addiction_Homo sapiens_hsa050300.24773418
114Hedgehog signaling pathway_Homo sapiens_hsa043400.24722967
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23656734
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23455200
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23267884
118Melanogenesis_Homo sapiens_hsa049160.23207957
119Caffeine metabolism_Homo sapiens_hsa002320.22997366
120Wnt signaling pathway_Homo sapiens_hsa043100.22498219
121Dilated cardiomyopathy_Homo sapiens_hsa054140.22133090
122Fat digestion and absorption_Homo sapiens_hsa049750.21725351
123TGF-beta signaling pathway_Homo sapiens_hsa043500.19735306
124Rheumatoid arthritis_Homo sapiens_hsa053230.19325247
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18609583
126Salivary secretion_Homo sapiens_hsa049700.18141044
127Insulin secretion_Homo sapiens_hsa049110.18094227
128Glutathione metabolism_Homo sapiens_hsa004800.17042568
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.16746415
130Linoleic acid metabolism_Homo sapiens_hsa005910.14088602
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13023681
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.12319902
133Tyrosine metabolism_Homo sapiens_hsa003500.12273664
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.12193950
135Gastric acid secretion_Homo sapiens_hsa049710.12122158
136Fatty acid elongation_Homo sapiens_hsa000620.12035059
137Thyroid cancer_Homo sapiens_hsa052160.10805425
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10484746
139Glucagon signaling pathway_Homo sapiens_hsa049220.08796843
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08537362

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