ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	thyroid hormone generation (GO:0006590)	8.10131351
2	neurotransmitter-gated ion channel clustering (GO:0072578)	6.85653259
3	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	6.62019180
4	negative regulation of translation, ncRNA-mediated (GO:0040033)	6.62019180
5	regulation of translation, ncRNA-mediated (GO:0045974)	6.62019180
6	thyroid hormone metabolic process (GO:0042403)	6.47913536
7	regulation of axon regeneration (GO:0048679)	6.19455257
8	regulation of neuron projection regeneration (GO:0070570)	6.19455257
9	cellular modified amino acid catabolic process (GO:0042219)	5.67309431
10	proline transport (GO:0015824)	5.50862445
11	heparin biosynthetic process (GO:0030210)	4.92314068
12	heparin metabolic process (GO:0030202)	4.92314068
13	long-chain fatty acid biosynthetic process (GO:0042759)	4.80824142
14	neuronal action potential propagation (GO:0019227)	4.72298646
15	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	4.54543987
16	glutamate receptor signaling pathway (GO:0007215)	4.53293132
17	ectoderm development (GO:0007398)	4.39797341
18	negative regulation of astrocyte differentiation (GO:0048712)	4.34997400
19	fatty acid elongation (GO:0030497)	4.26963599
20	regulation of timing of cell differentiation (GO:0048505)	4.22671496
21	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.07815120
22	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.98774645
23	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.98312220
24	regulation of collateral sprouting (GO:0048670)	3.95521323
25	meiotic chromosome segregation (GO:0045132)	3.92956803
26	regulation of development, heterochronic (GO:0040034)	3.87854731
27	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	3.63701654
28	phosphatidylethanolamine metabolic process (GO:0046337)	3.58335925
29	piRNA metabolic process (GO:0034587)	3.54023167
30	nonmotile primary cilium assembly (GO:0035058)	3.52388394
31	thalamus development (GO:0021794)	3.50833625
32	amino acid salvage (GO:0043102)	3.49542305
33	L-methionine salvage (GO:0071267)	3.49542305
34	L-methionine biosynthetic process (GO:0071265)	3.49542305
35	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.44402086
36	central nervous system neuron axonogenesis (GO:0021955)	3.43615051
37	C4-dicarboxylate transport (GO:0015740)	3.41206645
38	cochlea development (GO:0090102)	3.39664148
39	gamma-aminobutyric acid transport (GO:0015812)	3.36648751
40	male meiosis I (GO:0007141)	3.34298136
41	establishment of nucleus localization (GO:0040023)	3.32558257
42	vocalization behavior (GO:0071625)	3.32050410
43	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.25544526
44	sex differentiation (GO:0007548)	3.22717834
45	neuronal ion channel clustering (GO:0045161)	3.21976633
46	synapsis (GO:0007129)	3.19385259
47	DNA methylation involved in gamete generation (GO:0043046)	3.19347041
48	barbed-end actin filament capping (GO:0051016)	3.17694295
49	oligodendrocyte differentiation (GO:0048709)	3.15353109
50	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.09146434
51	behavioral response to ethanol (GO:0048149)	3.04275372
52	N-terminal protein amino acid acetylation (GO:0006474)	3.02915479
53	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	3.01737615
54	coronary vasculature morphogenesis (GO:0060977)	3.00486500
55	positive regulation of actin cytoskeleton reorganization (GO:2000251)	2.96389440
56	transmission of nerve impulse (GO:0019226)	2.93918289
57	positive regulation of guanylate cyclase activity (GO:0031284)	2.93009824
58	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.88713981
59	cerebellar Purkinje cell layer development (GO:0021680)	2.87945283
60	positive regulation of meiosis (GO:0045836)	2.86839057
61	positive regulation of developmental pigmentation (GO:0048087)	2.85467050
62	male meiosis (GO:0007140)	2.82109476
63	neuron recognition (GO:0008038)	2.79820241
64	histone H4-K8 acetylation (GO:0043982)	2.78537607
65	histone H4-K5 acetylation (GO:0043981)	2.78537607
66	hormone biosynthetic process (GO:0042446)	2.74790067
67	protein K11-linked deubiquitination (GO:0035871)	2.74622960
68	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.74113226
69	retinal cone cell development (GO:0046549)	2.73897649
70	chaperone-mediated protein complex assembly (GO:0051131)	2.72117022
71	mechanoreceptor differentiation (GO:0042490)	2.71736928
72	lens fiber cell differentiation (GO:0070306)	2.70405412
73	negative regulation of dendrite development (GO:2000171)	2.69420632
74	positive regulation of meiotic cell cycle (GO:0051446)	2.69388788
75	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.69038155
76	meiosis I (GO:0007127)	2.68636919
77	sulfate transport (GO:0008272)	2.66520882
78	signal complex assembly (GO:0007172)	2.66263244
79	methionine metabolic process (GO:0006555)	2.64304640
80	branched-chain amino acid catabolic process (GO:0009083)	2.64187430
81	protein localization to synapse (GO:0035418)	2.64140452
82	ephrin receptor signaling pathway (GO:0048013)	2.64037900
83	DNA double-strand break processing (GO:0000729)	2.62848301
84	regulation of Rac GTPase activity (GO:0032314)	2.60843795
85	DNA replication-dependent nucleosome assembly (GO:0006335)	2.60463569
86	DNA replication-dependent nucleosome organization (GO:0034723)	2.60463569
87	retinal metabolic process (GO:0042574)	2.60148069
88	regulation of astrocyte differentiation (GO:0048710)	2.59826003
89	regulation of guanylate cyclase activity (GO:0031282)	2.59715868
90	axonal fasciculation (GO:0007413)	2.59393916
91	dopamine transport (GO:0015872)	2.57466537
92	7-methylguanosine mRNA capping (GO:0006370)	2.56621132
93	central nervous system projection neuron axonogenesis (GO:0021952)	2.55320396
94	synaptic transmission, glutamatergic (GO:0035249)	2.53443137
95	histone H4-K12 acetylation (GO:0043983)	2.53166356
96	response to pheromone (GO:0019236)	2.52014109
97	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.51559546
98	presynaptic membrane assembly (GO:0097105)	2.50087630
99	phenol-containing compound catabolic process (GO:0019336)	13.5797624
100	hormone catabolic process (GO:0042447)	11.4518495

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAF15_26573619_Chip-Seq_HEK293_Human	6.28968691
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.80092757
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.40471143
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.02329744
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.01821286
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.96380169
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89409511
8	EWS_26573619_Chip-Seq_HEK293_Human	2.89384395
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.63692126
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.63184113
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60761439
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30876066
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.30876066
14	AR_21572438_ChIP-Seq_LNCaP_Human	2.26929371
15	P300_19829295_ChIP-Seq_ESCs_Human	2.24876648
16	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.21002154
17	FUS_26573619_Chip-Seq_HEK293_Human	2.16882329
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.09518294
19	AR_25329375_ChIP-Seq_VCAP_Human	2.06890095
20	SMAD4_21799915_ChIP-Seq_A2780_Human	2.05026105
21	RXR_22108803_ChIP-Seq_LS180_Human	2.03251321
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.99079254
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.98737146
24	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.98214915
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.94078394
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.92616341
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87315729
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.81028158
29	VDR_22108803_ChIP-Seq_LS180_Human	1.80846699
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69094254
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.68537740
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.68323140
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67882760
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62125667
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.59352228
36	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.58924543
37	TP53_16413492_ChIP-PET_HCT116_Human	1.53278726
38	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.52964986
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52388648
40	TCF4_23295773_ChIP-Seq_U87_Human	1.51455559
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51068588
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48748337
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.46196922
44	STAT3_23295773_ChIP-Seq_U87_Human	1.43433405
45	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42467993
46	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41196256
47	SOX9_26525672_Chip-Seq_HEART_Mouse	1.39121719
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37397871
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35841307
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.30645816
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30240645
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28640345
53	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.27993329
54	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.26192669
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23809914
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23547616
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21590431
58	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.21390367
59	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21348476
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20790826
61	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.18976784
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18567520
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.14954855
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14954855
65	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12598580
66	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.12549204
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.11783677
68	TP53_18474530_ChIP-ChIP_U2OS_Human	1.11379114
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09385758
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.09369057
71	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.09281062
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.08015229
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07631781
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.06754488
75	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06599775
76	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.05858349
77	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05707918
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05144020
79	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.03957286
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.01729739
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00779588
82	NFYA_21822215_ChIP-Seq_K562_Human	1.00157159
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.99996383
84	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.99332076
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98881873
86	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.98528006
87	KDM2B_26808549_Chip-Seq_REH_Human	0.97748432
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96384728
89	TBL1_22424771_ChIP-Seq_293T_Human	0.94471046
90	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.94215564
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.92905537
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.92285494
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92027873
94	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91942212
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.91758308
96	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.91680425
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.91288255
98	NFYB_21822215_ChIP-Seq_K562_Human	0.90197836
99	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.87221020
100	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.86979710

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	5.50754254
2	MP0003868_abnormal_feces_composition	5.39790074
3	MP0000569_abnormal_digit_pigmentation	4.98360853
4	MP0001968_abnormal_touch/_nociception	3.89052647
5	MP0002102_abnormal_ear_morphology	3.15372844
6	MP0008877_abnormal_DNA_methylation	3.04240799
7	MP0003880_abnormal_central_pattern	2.69034638
8	MP0002733_abnormal_thermal_nociception	2.31855598
9	MP0002139_abnormal_hepatobiliary_system	2.31761331
10	MP0000015_abnormal_ear_pigmentation	2.20402908
11	MP0002234_abnormal_pharynx_morphology	1.97097056
12	MP0005174_abnormal_tail_pigmentation	1.95947035
13	MP0000566_synostosis	1.93772894
14	MP0002233_abnormal_nose_morphology	1.88967091
15	MP0009745_abnormal_behavioral_response	1.75419917
16	MP0001970_abnormal_pain_threshold	1.65253080
17	MP0003635_abnormal_synaptic_transmissio	1.64704007
18	MP0005084_abnormal_gallbladder_morpholo	1.62956161
19	MP0008875_abnormal_xenobiotic_pharmacok	1.60033449
20	MP0000778_abnormal_nervous_system	1.52718032
21	MP0003755_abnormal_palate_morphology	1.52009308
22	MP0001486_abnormal_startle_reflex	1.51865964
23	MP0002272_abnormal_nervous_system	1.50718519
24	MP0001666_abnormal_nutrient_absorption	1.48408065
25	MP0002064_seizures	1.47835134
26	MP0002089_abnormal_postnatal_growth/wei	1.40463555
27	MP0001177_atelectasis	1.38459509
28	MP0000427_abnormal_hair_cycle	1.36449501
29	MP0003937_abnormal_limbs/digits/tail_de	1.32404388
30	MP0004859_abnormal_synaptic_plasticity	1.30954522
31	MP0010678_abnormal_skin_adnexa	1.29580483
32	MP0002063_abnormal_learning/memory/cond	1.29158317
33	MP0003119_abnormal_digestive_system	1.28947707
34	MP0000383_abnormal_hair_follicle	1.28454143
35	MP0010234_abnormal_vibrissa_follicle	1.24413484
36	MP0002095_abnormal_skin_pigmentation	1.23746189
37	MP0009697_abnormal_copulation	1.23441197
38	MP0002210_abnormal_sex_determination	1.19272989
39	MP0002160_abnormal_reproductive_system	1.18803286
40	MP0006054_spinal_hemorrhage	1.18341116
41	MP0002837_dystrophic_cardiac_calcinosis	1.18316490
42	MP0001501_abnormal_sleep_pattern	1.17149928
43	MP0001764_abnormal_homeostasis	1.16959131
44	MP0002067_abnormal_sensory_capabilities	1.16616503
45	MP0003283_abnormal_digestive_organ	1.16091347
46	MP0003252_abnormal_bile_duct	1.14569394
47	MP0003698_abnormal_male_reproductive	1.13696491
48	MP0002184_abnormal_innervation	1.12902927
49	MP0000631_abnormal_neuroendocrine_gland	1.11484926
50	MP0003136_yellow_coat_color	1.10063214
51	MP0001529_abnormal_vocalization	1.09566222
52	MP0005646_abnormal_pituitary_gland	1.08407888
53	MP0001929_abnormal_gametogenesis	1.06263702
54	MP0008872_abnormal_physiological_respon	1.04596708
55	MP0000372_irregular_coat_pigmentation	1.03768412
56	MP0006292_abnormal_olfactory_placode	1.03040063
57	MP0002572_abnormal_emotion/affect_behav	1.02669912
58	MP0004145_abnormal_muscle_electrophysio	1.02197562
59	MP0002938_white_spotting	1.01845941
60	MP0004043_abnormal_pH_regulation	1.00210559
61	MP0010030_abnormal_orbit_morphology	0.99202102
62	MP0002928_abnormal_bile_duct	0.97089670
63	MP0001984_abnormal_olfaction	0.96998767
64	MP0005551_abnormal_eye_electrophysiolog	0.93627608
65	MP0003633_abnormal_nervous_system	0.92203202
66	MP0001919_abnormal_reproductive_system	0.89682372
67	MP0003935_abnormal_craniofacial_develop	0.88825668
68	MP0001145_abnormal_male_reproductive	0.88424568
69	MP0000647_abnormal_sebaceous_gland	0.88370217
70	MP0000653_abnormal_sex_gland	0.88263524
71	MP0001188_hyperpigmentation	0.86667188
72	MP0004085_abnormal_heartbeat	0.86519524
73	MP0004924_abnormal_behavior	0.85243244
74	MP0005386_behavior/neurological_phenoty	0.85243244
75	MP0005187_abnormal_penis_morphology	0.81370024
76	MP0002557_abnormal_social/conspecific_i	0.81102386
77	MP0008569_lethality_at_weaning	0.80425011
78	MP0004811_abnormal_neuron_physiology	0.79074930
79	MP0002066_abnormal_motor_capabilities/c	0.78080002
80	MP0002295_abnormal_pulmonary_circulatio	0.77912792
81	MP0000955_abnormal_spinal_cord	0.77040190
82	MP0009046_muscle_twitch	0.76455157
83	MP0005389_reproductive_system_phenotype	0.75482532
84	MP0005670_abnormal_white_adipose	0.75266562
85	MP0005410_abnormal_fertilization	0.73615839
86	MP0002882_abnormal_neuron_morphology	0.73147987
87	MP0000462_abnormal_digestive_system	0.73117673
88	MP0003137_abnormal_impulse_conducting	0.69345010
89	MP0009703_decreased_birth_body	0.69057216
90	MP0000465_gastrointestinal_hemorrhage	0.67311133
91	MP0002735_abnormal_chemical_nociception	0.66362537
92	MP0002282_abnormal_trachea_morphology	0.64277934
93	MP0002734_abnormal_mechanical_nocicepti	0.63475299
94	MP0004883_abnormal_blood_vessel	0.63022673
95	MP0004142_abnormal_muscle_tone	0.61638858
96	MP0001270_distended_abdomen	0.61445523
97	MP0010771_integument_phenotype	0.61103655
98	MP0010770_preweaning_lethality	0.60137823
99	MP0002082_postnatal_lethality	0.60137823
100	MP0008789_abnormal_olfactory_epithelium	0.58303399

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Albinism (HP:0001022)	4.25202407
2	Gait imbalance (HP:0002141)	3.96482107
3	Congenital primary aphakia (HP:0007707)	3.84986766
4	Hyperventilation (HP:0002883)	3.82311649
5	Progressive inability to walk (HP:0002505)	3.80961591
6	Type II lissencephaly (HP:0007260)	3.66850693
7	Nephrogenic diabetes insipidus (HP:0009806)	3.42217775
8	Medial flaring of the eyebrow (HP:0010747)	3.40326120
9	Abnormality of the labia majora (HP:0012881)	3.39448419
10	Sensorimotor neuropathy (HP:0007141)	3.32211101
11	Spondylolisthesis (HP:0003302)	3.26284201
12	Focal motor seizures (HP:0011153)	3.25685124
13	Vaginal atresia (HP:0000148)	3.17718671
14	Genital tract atresia (HP:0001827)	3.14638347
15	Spastic paraparesis (HP:0002313)	3.13761762
16	Hypoplastic labia majora (HP:0000059)	3.09674973
17	Inability to walk (HP:0002540)	3.05843783
18	Poor coordination (HP:0002370)	3.02350431
19	Cerebellar dysplasia (HP:0007033)	3.01272021
20	Slender build (HP:0001533)	2.93239445
21	Intestinal atresia (HP:0011100)	2.91644593
22	Ulnar claw (HP:0001178)	2.65525996
23	Amyotrophic lateral sclerosis (HP:0007354)	2.59843527
24	Abnormality of the vocal cords (HP:0008777)	2.58327275
25	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.57865580
26	Hypoplastic iliac wings (HP:0002866)	2.57008578
27	Increased serum pyruvate (HP:0003542)	2.56944784
28	Acanthocytosis (HP:0001927)	2.52662929
29	Prominent metopic ridge (HP:0005487)	2.52560377
30	Epidermoid cyst (HP:0200040)	2.42347590
31	CNS hypomyelination (HP:0003429)	2.39180716
32	Neoplasm of the adrenal cortex (HP:0100641)	2.35141290
33	Amniotic constriction ring (HP:0009775)	2.35089185
34	Abnormality of placental membranes (HP:0011409)	2.35089185
35	Widely spaced teeth (HP:0000687)	2.34753187
36	Colon cancer (HP:0003003)	2.33691570
37	Poor speech (HP:0002465)	2.33680598
38	Papillary thyroid carcinoma (HP:0002895)	2.29891745
39	Focal seizures (HP:0007359)	2.27649384
40	Absent speech (HP:0001344)	2.27059555
41	Lower limb hyperreflexia (HP:0002395)	2.26989901
42	Wide intermamillary distance (HP:0006610)	2.25370584
43	Abnormality of the metopic suture (HP:0005556)	2.24852536
44	Aplasia/Hypoplasia of the lens (HP:0008063)	2.23047007
45	Hip dysplasia (HP:0001385)	2.22034735
46	Postural instability (HP:0002172)	2.19236205
47	Abnormality of the labia minora (HP:0012880)	2.18489450
48	Humeroradial synostosis (HP:0003041)	2.16398795
49	Synostosis involving the elbow (HP:0003938)	2.16398795
50	Retinal dysplasia (HP:0007973)	2.16328658
51	Drooling (HP:0002307)	2.13588601
52	Abnormality of the pubic bones (HP:0003172)	2.13307595
53	Thickened helices (HP:0000391)	2.12129969
54	Abnormality of glycolysis (HP:0004366)	2.10682937
55	Optic nerve hypoplasia (HP:0000609)	2.10532193
56	Rib fusion (HP:0000902)	2.10048649
57	Febrile seizures (HP:0002373)	2.09659529
58	Inappropriate behavior (HP:0000719)	2.08758361
59	Bile duct proliferation (HP:0001408)	2.07287156
60	Abnormal biliary tract physiology (HP:0012439)	2.07287156
61	Dental crowding (HP:0000678)	2.05995374
62	Heterotopia (HP:0002282)	2.04852478
63	Gastrointestinal atresia (HP:0002589)	2.01731075
64	Lissencephaly (HP:0001339)	2.00612800
65	Abnormality of the renal medulla (HP:0100957)	1.99086595
66	Microvesicular hepatic steatosis (HP:0001414)	1.98914441
67	Type I transferrin isoform profile (HP:0003642)	1.98690662
68	Lipid accumulation in hepatocytes (HP:0006561)	1.96733472
69	Abnormality of the labia (HP:0000058)	1.94678820
70	Left ventricular hypertrophy (HP:0001712)	1.94555434
71	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.94047445
72	Premature ovarian failure (HP:0008209)	1.92234117
73	Nephronophthisis (HP:0000090)	1.91014680
74	Excessive salivation (HP:0003781)	1.90281951
75	Narrow palate (HP:0000189)	1.89832379
76	Polycythemia (HP:0001901)	1.89565412
77	Horizontal nystagmus (HP:0000666)	1.89177548
78	Thyroid-stimulating hormone excess (HP:0002925)	1.88986494
79	Specific learning disability (HP:0001328)	1.88091166
80	Increased hepatocellular lipid droplets (HP:0006565)	1.86865760
81	Thyroid carcinoma (HP:0002890)	1.85734589
82	Abnormality of the fingertips (HP:0001211)	1.84641072
83	Metaphyseal dysplasia (HP:0100255)	1.83274009
84	Hypomagnesemia (HP:0002917)	1.81580409
85	Vertebral fusion (HP:0002948)	1.80434519
86	Stomach cancer (HP:0012126)	1.79898796
87	Hypoglycemic coma (HP:0001325)	1.77520340
88	Sparse scalp hair (HP:0002209)	1.77065688
89	Neonatal respiratory distress (HP:0002643)	1.77064456
90	Neoplasm of the oral cavity (HP:0100649)	1.76060121
91	Abnormal social behavior (HP:0012433)	1.75884342
92	Impaired social interactions (HP:0000735)	1.75884342
93	Volvulus (HP:0002580)	1.75535810
94	Increased number of teeth (HP:0011069)	1.72801552
95	Broad foot (HP:0001769)	1.71530808
96	Pancreatic fibrosis (HP:0100732)	1.71146604
97	Decreased testicular size (HP:0008734)	1.70156813
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69430690
99	Decreased muscle mass (HP:0003199)	1.69215864
100	Tongue fasciculations (HP:0001308)	1.69128454

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NTRK3	6.32034485
2	PNCK	4.17724992
3	DYRK3	3.61191025
4	CASK	3.58652595
5	FRK	3.58082571
6	MAP4K2	3.49303391
7	TNIK	3.14949624
8	MAPK13	3.00641945
9	EPHA4	2.33754347
10	ZAK	2.21381533
11	AKT3	2.12859832
12	BRD4	2.08788852
13	MET	2.04875049
14	RPS6KA4	1.92222008
15	BRAF	1.90850363
16	MARK1	1.87038349
17	FGR	1.79337355
18	SGK2	1.76308189
19	MST4	1.72349331
20	CDK19	1.56496183
21	FGFR2	1.55544673
22	TLK1	1.53475381
23	SGK494	1.26508385
24	SGK223	1.26508385
25	PTK2B	1.23916205
26	KSR1	1.18799681
27	MAP3K4	1.12938882
28	OXSR1	1.10429266
29	RAF1	1.08941083
30	TTK	1.04857000
31	CDC7	1.02358925
32	CSF1R	1.00583438
33	ADRBK2	1.00432914
34	WNK3	0.99350343
35	PRKCZ	0.97069258
36	MAP3K2	0.94339210
37	BMX	0.91653487
38	KSR2	0.90595125
39	CDK3	0.87771986
40	MAP2K1	0.83309332
41	MATK	0.83203220
42	SGK3	0.79606068
43	PRKCG	0.79099131
44	CAMK1G	0.78329722
45	MAP2K7	0.72649583
46	SIK2	0.71498932
47	MAP3K6	0.70243800
48	MAP3K5	0.69488042
49	RET	0.68603067
50	PIK3CA	0.65244146
51	DYRK2	0.64450048
52	PLK4	0.61453742
53	PDGFRB	0.60549656
54	ATR	0.60512894
55	ROCK1	0.60357956
56	TAOK3	0.59820833
57	EPHA3	0.58964701
58	CAMK2G	0.58903996
59	INSRR	0.56379921
60	NEK6	0.56112467
61	CDK5	0.55619348
62	ICK	0.52252601
63	SGK1	0.51531649
64	MAPKAPK3	0.49006200
65	MAP2K4	0.48934160
66	PLK1	0.48589071
67	YES1	0.47956958
68	ERBB2	0.47060286
69	NEK1	0.46329670
70	RPS6KB2	0.45284258
71	CSNK1E	0.44786608
72	BMPR2	0.42526511
73	CHEK2	0.42384095
74	MINK1	0.42303424
75	PRKG1	0.42129974
76	ATM	0.41757908
77	TYRO3	0.41027304
78	PAK3	0.40605576
79	PRKACG	0.39873843
80	ILK	0.38486653
81	RPS6KA5	0.33640302
82	IGF1R	0.33064743
83	PAK6	0.32620345
84	PRKD1	0.30688481
85	CHEK1	0.30345762
86	PRKCE	0.27776046
87	GRK1	0.27174781
88	CAMK2A	0.25050231
89	CSNK1A1	0.24446400
90	PKN1	0.24342553
91	WEE1	0.23998823
92	CDK9	0.23589833
93	TAOK1	0.23360913
94	CSNK1D	0.22225988
95	NTRK2	0.21230665
96	PLK2	0.20992395
97	RPS6KB1	0.20878051
98	SRPK1	0.19785402
99	PRKACA	0.19168673
100	GSK3B	0.18014955

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.07117951
2	Taste transduction_Homo sapiens_hsa04742	2.80610999
3	Phototransduction_Homo sapiens_hsa04744	2.62021615
4	Cocaine addiction_Homo sapiens_hsa05030	2.49825609
5	Glutamatergic synapse_Homo sapiens_hsa04724	2.44310817
6	Circadian entrainment_Homo sapiens_hsa04713	2.32945584
7	Amphetamine addiction_Homo sapiens_hsa05031	2.17786450
8	Olfactory transduction_Homo sapiens_hsa04740	2.13084666
9	Propanoate metabolism_Homo sapiens_hsa00640	2.10094646
10	Basal transcription factors_Homo sapiens_hsa03022	1.95043482
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.93347294
12	Long-term depression_Homo sapiens_hsa04730	1.87382839
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.83117389
14	RNA polymerase_Homo sapiens_hsa03020	1.80174893
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.79514249
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.72665298
17	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.70980666
18	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.69612250
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67128370
20	Dopaminergic synapse_Homo sapiens_hsa04728	1.64708777
21	African trypanosomiasis_Homo sapiens_hsa05143	1.61443708
22	Fatty acid elongation_Homo sapiens_hsa00062	1.47214003
23	Renin secretion_Homo sapiens_hsa04924	1.41032218
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.40395919
25	Morphine addiction_Homo sapiens_hsa05032	1.36359133
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.35680998
27	Butanoate metabolism_Homo sapiens_hsa00650	1.33707437
28	Serotonergic synapse_Homo sapiens_hsa04726	1.23380802
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.20794944
30	Alcoholism_Homo sapiens_hsa05034	1.17597081
31	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.15134575
32	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.09732999
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.05732216
34	Huntingtons disease_Homo sapiens_hsa05016	1.05255362
35	Calcium signaling pathway_Homo sapiens_hsa04020	1.03225242
36	Estrogen signaling pathway_Homo sapiens_hsa04915	1.02032043
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.98992996
38	ErbB signaling pathway_Homo sapiens_hsa04012	0.98122238
39	Regulation of autophagy_Homo sapiens_hsa04140	0.97097749
40	Cholinergic synapse_Homo sapiens_hsa04725	0.96855381
41	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.96599536
42	Sphingolipid metabolism_Homo sapiens_hsa00600	0.95941357
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94119432
44	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.94051734
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92441467
46	cAMP signaling pathway_Homo sapiens_hsa04024	0.91555278
47	Proteasome_Homo sapiens_hsa03050	0.90190439
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88900085
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84817187
50	Parkinsons disease_Homo sapiens_hsa05012	0.83827348
51	GABAergic synapse_Homo sapiens_hsa04727	0.79231416
52	Sulfur metabolism_Homo sapiens_hsa00920	0.78054682
53	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.77588313
54	Axon guidance_Homo sapiens_hsa04360	0.76805393
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.75699763
56	Endometrial cancer_Homo sapiens_hsa05213	0.72108526
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.71790332
58	Homologous recombination_Homo sapiens_hsa03440	0.71633087
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.71404715
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.67375538
61	Caffeine metabolism_Homo sapiens_hsa00232	0.66784988
62	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66417944
63	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.65927506
64	Colorectal cancer_Homo sapiens_hsa05210	0.63532730
65	Salivary secretion_Homo sapiens_hsa04970	0.63223255
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62166901
67	Choline metabolism in cancer_Homo sapiens_hsa05231	0.61453664
68	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.61054728
69	Histidine metabolism_Homo sapiens_hsa00340	0.60686747
70	Type II diabetes mellitus_Homo sapiens_hsa04930	0.55282325
71	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.54730436
72	RNA degradation_Homo sapiens_hsa03018	0.52783401
73	Oxidative phosphorylation_Homo sapiens_hsa00190	0.52372331
74	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.52295273
75	mTOR signaling pathway_Homo sapiens_hsa04150	0.51448127
76	Alzheimers disease_Homo sapiens_hsa05010	0.50511295
77	Purine metabolism_Homo sapiens_hsa00230	0.49558587
78	Insulin secretion_Homo sapiens_hsa04911	0.49217138
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48869991
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47639784
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47033437
82	Chemokine signaling pathway_Homo sapiens_hsa04062	0.45040818
83	Long-term potentiation_Homo sapiens_hsa04720	0.43942954
84	Pancreatic secretion_Homo sapiens_hsa04972	0.43169485
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41957834
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41670742
87	TNF signaling pathway_Homo sapiens_hsa04668	0.41449067
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41253651
89	Lysine degradation_Homo sapiens_hsa00310	0.41066375
90	Melanoma_Homo sapiens_hsa05218	0.41035541
91	Gap junction_Homo sapiens_hsa04540	0.40109687
92	Prostate cancer_Homo sapiens_hsa05215	0.40098306
93	RNA transport_Homo sapiens_hsa03013	0.38768843
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.38144364
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37871668
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37170037
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.36294055
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35036954
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.33568373
100	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.31114450

FKBP4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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