ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	microtubule polymerization or depolymerization (GO:0031109)	8.64816806
2	mitotic sister chromatid segregation (GO:0000070)	8.49162186
3	hematopoietic stem cell proliferation (GO:0071425)	8.23031180
4	positive regulation of lamellipodium assembly (GO:0010592)	7.54745722
5	sister chromatid segregation (GO:0000819)	7.48154775
6	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	7.16044577
7	spinal cord association neuron differentiation (GO:0021527)	7.12314975
8	midbrain development (GO:0030901)	6.51450472
9	positive regulation of lamellipodium organization (GO:1902745)	5.80982745
10	myoblast fusion (GO:0007520)	5.67107472
11	protein depolymerization (GO:0051261)	5.56576928
12	viral transcription (GO:0019083)	5.52663801
13	translational termination (GO:0006415)	5.20850816
14	cellular protein complex disassembly (GO:0043624)	5.10174034
15	positive regulation of embryonic development (GO:0040019)	5.01301163
16	ribosomal small subunit assembly (GO:0000028)	4.95953707
17	syncytium formation by plasma membrane fusion (GO:0000768)	4.87531667
18	cotranslational protein targeting to membrane (GO:0006613)	4.82617491
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.82151713
20	positive regulation of Notch signaling pathway (GO:0045747)	4.74802799
21	protein targeting to ER (GO:0045047)	4.73044262
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.65182561
23	translational elongation (GO:0006414)	4.64276173
24	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	4.59897848
25	ribosomal small subunit biogenesis (GO:0042274)	4.58607944
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.57256293
27	acrosome assembly (GO:0001675)	4.52932047
28	protein complex disassembly (GO:0043241)	4.43377999
29	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.38622312
30	protein localization to endoplasmic reticulum (GO:0070972)	4.38100370
31	regulation of cell aging (GO:0090342)	4.29157102
32	macromolecular complex disassembly (GO:0032984)	4.23936804
33	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	4.17484087
34	ATP synthesis coupled proton transport (GO:0015986)	4.17322306
35	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.17322306
36	translational initiation (GO:0006413)	4.02698029
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.98899552
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.98899552
39	NADH dehydrogenase complex assembly (GO:0010257)	3.98899552
40	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.96540379
41	thalamus development (GO:0021794)	3.95607844
42	syncytium formation (GO:0006949)	3.94722566
43	urogenital system development (GO:0001655)	3.93772107
44	viral life cycle (GO:0019058)	3.83713391
45	cell differentiation in spinal cord (GO:0021515)	3.83051726
46	Sertoli cell development (GO:0060009)	3.77377414
47	regulation of lamellipodium assembly (GO:0010591)	3.77255704
48	protein complex biogenesis (GO:0070271)	3.75041674
49	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.73249882
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.68904529
51	centriole replication (GO:0007099)	3.64898033
52	spermatid nucleus differentiation (GO:0007289)	3.62711923
53	establishment of integrated proviral latency (GO:0075713)	3.61969313
54	organelle disassembly (GO:1903008)	3.60516826
55	respiratory electron transport chain (GO:0022904)	3.50752935
56	mitochondrial respiratory chain complex assembly (GO:0033108)	3.48800397
57	electron transport chain (GO:0022900)	3.39734908
58	kinetochore assembly (GO:0051382)	3.39060280
59	embryonic axis specification (GO:0000578)	3.36977383
60	kinetochore organization (GO:0051383)	3.35036544
61	protein targeting to membrane (GO:0006612)	3.29326678
62	maturation of SSU-rRNA (GO:0030490)	3.23572468
63	cell fate determination (GO:0001709)	3.23018957
64	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.15387975
65	translation (GO:0006412)	3.07117551
66	inner mitochondrial membrane organization (GO:0007007)	3.06362875
67	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.06239493
68	spliceosomal complex assembly (GO:0000245)	3.01419019
69	histone H2B ubiquitination (GO:0033523)	2.99277125
70	establishment of viral latency (GO:0019043)	2.98624659
71	inner ear morphogenesis (GO:0042472)	2.96307401
72	mRNA catabolic process (GO:0006402)	2.94622620
73	DNA damage response, detection of DNA damage (GO:0042769)	2.93717559
74	histone exchange (GO:0043486)	2.92294308
75	DNA ligation (GO:0006266)	2.92049901
76	regulation of lamellipodium organization (GO:1902743)	2.90080849
77	purine deoxyribonucleotide catabolic process (GO:0009155)	2.83977294
78	CENP-A containing nucleosome assembly (GO:0034080)	2.81101680
79	rRNA modification (GO:0000154)	2.77345778
80	chromatin remodeling at centromere (GO:0031055)	2.73241054
81	rRNA methylation (GO:0031167)	2.72986021
82	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.72535183
83	T cell differentiation in thymus (GO:0033077)	2.72197447
84	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.69988848
85	RNA catabolic process (GO:0006401)	2.65843474
86	formation of translation preinitiation complex (GO:0001731)	2.64801694
87	7-methylguanosine mRNA capping (GO:0006370)	2.63245427
88	centriole assembly (GO:0098534)	2.63034808
89	response to redox state (GO:0051775)	2.59341786
90	stem cell proliferation (GO:0072089)	2.58963464
91	pyrimidine nucleobase catabolic process (GO:0006208)	2.58661787
92	positive regulation of fibroblast proliferation (GO:0048146)	2.57808726
93	positive regulation of gastrulation (GO:2000543)	2.56821856
94	7-methylguanosine RNA capping (GO:0009452)	2.56567469
95	RNA capping (GO:0036260)	2.56567469
96	chromosome segregation (GO:0007059)	2.55383139
97	microtubule depolymerization (GO:0007019)	15.0009579
98	neuron fate determination (GO:0048664)	13.6018689
99	hepatocyte differentiation (GO:0070365)	11.0465424
100	negative regulation of cell aging (GO:0090344)	10.3670351

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.37031647
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.96339103
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.99028559
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.85035419
5	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.66286182
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.48742525
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.20561957
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.17432830
9	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.05159453
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.04938406
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.04323674
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.94563867
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.77611307
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.59048677
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.58398702
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.43258891
17	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.40415614
18	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.26910228
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.24471369
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.16266679
21	AR_21909140_ChIP-Seq_LNCAP_Human	2.11808014
22	XRN2_22483619_ChIP-Seq_HELA_Human	2.11617309
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11026088
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08598267
25	VDR_23849224_ChIP-Seq_CD4+_Human	2.07410281
26	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.00877916
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.00090481
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.98225300
29	E2F7_22180533_ChIP-Seq_HELA_Human	1.96552383
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.95695927
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.94029572
32	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.91706965
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.85649838
34	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81145789
35	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.79860715
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.74292890
37	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.73758734
38	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.73641368
39	FUS_26573619_Chip-Seq_HEK293_Human	1.70175898
40	ZNF274_21170338_ChIP-Seq_K562_Hela	1.68808607
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.62639949
42	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.61939548
43	EWS_26573619_Chip-Seq_HEK293_Human	1.58398943
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.56376863
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56056418
46	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.55589517
47	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.55249425
48	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.53510964
49	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.48380334
50	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46782280
51	DCP1A_22483619_ChIP-Seq_HELA_Human	1.40198759
52	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.39067848
53	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.38270882
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.36778447
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36622541
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34848221
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34085694
58	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.29766643
59	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.27101025
60	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.26667538
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.25540757
62	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.15185673
63	EZH2_22144423_ChIP-Seq_EOC_Human	1.12869004
64	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12428453
65	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.12045249
66	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.10376587
67	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.03669800
68	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.03210490
69	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.02255661
70	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01968711
71	TP53_22573176_ChIP-Seq_HFKS_Human	0.98928191
72	GABP_19822575_ChIP-Seq_HepG2_Human	0.98318114
73	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97188750
74	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.96287691
75	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.95767685
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.95667862
77	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.94707617
78	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94510123
79	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.91873604
80	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.91723608
81	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.89461357
82	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.87943608
83	IRF1_19129219_ChIP-ChIP_H3396_Human	0.84377808
84	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.83974109
85	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.82545260
86	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.80756654
87	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.80054810
88	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.79070485
89	P300_19829295_ChIP-Seq_ESCs_Human	0.76946451
90	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.75514098
91	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.75000593
92	AR_25329375_ChIP-Seq_VCAP_Human	0.73786747
93	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.73506901
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.72646898
95	AR_20517297_ChIP-Seq_VCAP_Human	0.71449521
96	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.71110086
97	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.70516729
98	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.70491684
99	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.70491684
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.70464325

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004510_myositis	6.71195404
2	MP0010030_abnormal_orbit_morphology	5.18470859
3	MP0004742_abnormal_vestibular_system	4.82795805
4	MP0004142_abnormal_muscle_tone	4.34434733
5	MP0002249_abnormal_larynx_morphology	4.28084305
6	MP0009379_abnormal_foot_pigmentation	3.77468937
7	MP0000569_abnormal_digit_pigmentation	3.39492819
8	MP0000566_synostosis	3.23362280
9	MP0000049_abnormal_middle_ear	3.06240815
10	MP0002938_white_spotting	2.83277319
11	MP0002102_abnormal_ear_morphology	2.64135647
12	MP0006082_CNS_inflammation	2.51235326
13	MP0003880_abnormal_central_pattern	2.51145589
14	MP0001873_stomach_inflammation	2.47383456
15	MP0003806_abnormal_nucleotide_metabolis	2.32248568
16	MP0003136_yellow_coat_color	2.31373542
17	MP0001293_anophthalmia	1.68528684
18	MP0008058_abnormal_DNA_repair	1.62915302
19	MP0002837_dystrophic_cardiac_calcinosis	1.58274060
20	MP0002234_abnormal_pharynx_morphology	1.57471774
21	MP0002697_abnormal_eye_size	1.55338370
22	MP0002139_abnormal_hepatobiliary_system	1.55136752
23	MP0000026_abnormal_inner_ear	1.53707889
24	MP0002277_abnormal_respiratory_mucosa	1.49315860
25	MP0005253_abnormal_eye_physiology	1.44245852
26	MP0002751_abnormal_autonomic_nervous	1.40624153
27	MP0006292_abnormal_olfactory_placode	1.40551388
28	MP0003111_abnormal_nucleus_morphology	1.36438916
29	MP0006276_abnormal_autonomic_nervous	1.34600402
30	MP0000778_abnormal_nervous_system	1.28100149
31	MP0000631_abnormal_neuroendocrine_gland	1.27897828
32	MP0006072_abnormal_retinal_apoptosis	1.26223376
33	MP0003693_abnormal_embryo_hatching	1.23869434
34	MP0010094_abnormal_chromosome_stability	1.18805592
35	MP0003122_maternal_imprinting	1.15427254
36	MP0003890_abnormal_embryonic-extraembry	1.10998756
37	MP0003646_muscle_fatigue	1.07148195
38	MP0005391_vision/eye_phenotype	1.06105813
39	MP0003938_abnormal_ear_development	1.05828600
40	MP0001286_abnormal_eye_development	1.04429675
41	MP0000372_irregular_coat_pigmentation	1.01676737
42	MP0002557_abnormal_social/conspecific_i	0.98732221
43	MP0003121_genomic_imprinting	0.97322643
44	MP0008789_abnormal_olfactory_epithelium	0.96759579
45	MP0005174_abnormal_tail_pigmentation	0.95772042
46	MP0008932_abnormal_embryonic_tissue	0.95736634
47	MP0002116_abnormal_craniofacial_bone	0.92852987
48	MP0006036_abnormal_mitochondrial_physio	0.91892505
49	MP0002095_abnormal_skin_pigmentation	0.91537013
50	MP0004145_abnormal_muscle_electrophysio	0.89080791
51	MP0002282_abnormal_trachea_morphology	0.88543602
52	MP0005410_abnormal_fertilization	0.87401206
53	MP0003937_abnormal_limbs/digits/tail_de	0.87340298
54	MP0001905_abnormal_dopamine_level	0.85998818
55	MP0003315_abnormal_perineum_morphology	0.85947974
56	MP0005394_taste/olfaction_phenotype	0.84395348
57	MP0005499_abnormal_olfactory_system	0.84395348
58	MP0003077_abnormal_cell_cycle	0.84140927
59	MP0003718_maternal_effect	0.83823823
60	MP0005084_abnormal_gallbladder_morpholo	0.81259971
61	MP0003861_abnormal_nervous_system	0.81072189
62	MP0005167_abnormal_blood-brain_barrier	0.80448899
63	MP0001663_abnormal_digestive_system	0.78794880
64	MP0002822_catalepsy	0.78530925
65	MP0003137_abnormal_impulse_conducting	0.78393518
66	MP0005645_abnormal_hypothalamus_physiol	0.77355904
67	MP0002085_abnormal_embryonic_tissue	0.77068831
68	MP0001929_abnormal_gametogenesis	0.76138177
69	MP0002210_abnormal_sex_determination	0.74041266
70	MP0002933_joint_inflammation	0.73979967
71	MP0002106_abnormal_muscle_physiology	0.72405645
72	MP0002084_abnormal_developmental_patter	0.71300716
73	MP0003011_delayed_dark_adaptation	0.68847981
74	MP0002752_abnormal_somatic_nervous	0.68409816
75	MP0002067_abnormal_sensory_capabilities	0.68306332
76	MP0002735_abnormal_chemical_nociception	0.67072675
77	MP0005551_abnormal_eye_electrophysiolog	0.64720627
78	MP0002272_abnormal_nervous_system	0.64679407
79	MP0001851_eye_inflammation	0.63711730
80	MP0001485_abnormal_pinna_reflex	0.63667510
81	MP0001529_abnormal_vocalization	0.63291686
82	MP0008004_abnormal_stomach_pH	0.62929029
83	MP0002653_abnormal_ependyma_morphology	0.62830931
84	MP0005195_abnormal_posterior_eye	0.62230149
85	MP0003186_abnormal_redox_activity	0.61936001
86	MP0003119_abnormal_digestive_system	0.60490721
87	MP0004957_abnormal_blastocyst_morpholog	0.60207825
88	MP0001697_abnormal_embryo_size	0.59754272
89	MP0009046_muscle_twitch	0.59429894
90	MP0003755_abnormal_palate_morphology	0.59173027
91	MP0002152_abnormal_brain_morphology	0.58146549
92	MP0000163_abnormal_cartilage_morphology	0.56993290
93	MP0001145_abnormal_male_reproductive	0.56664006
94	MP0002092_abnormal_eye_morphology	0.56219802
95	MP0000955_abnormal_spinal_cord	0.55728267
96	MP0005381_digestive/alimentary_phenotyp	0.55595063
97	MP0009840_abnormal_foam_cell	0.53784043
98	MP0001881_abnormal_mammary_gland	0.52906379
99	MP0001324_abnormal_eye_pigmentation	0.52253399
100	MP0000653_abnormal_sex_gland	0.50897233

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thin ribs (HP:0000883)	5.98950345
2	Increased hepatocellular lipid droplets (HP:0006565)	4.11600151
3	Congenital, generalized hypertrichosis (HP:0004540)	4.00301667
4	Lipid accumulation in hepatocytes (HP:0006561)	3.93382776
5	Septo-optic dysplasia (HP:0100842)	3.68540412
6	Constricted visual fields (HP:0001133)	3.55897489
7	Partial duplication of the phalanx of hand (HP:0009999)	3.48991467
8	Increased intramyocellular lipid droplets (HP:0012240)	3.38581366
9	Absent septum pellucidum (HP:0001331)	3.38172409
10	Amniotic constriction ring (HP:0009775)	3.34990077
11	Abnormality of placental membranes (HP:0011409)	3.34990077
12	Mitochondrial inheritance (HP:0001427)	3.30104624
13	Renal Fanconi syndrome (HP:0001994)	3.20131476
14	Abnormality of the septum pellucidum (HP:0007375)	3.10132964
15	Reticulocytopenia (HP:0001896)	3.08081481
16	Aplasia of the musculature (HP:0100854)	2.96605473
17	Increased muscle lipid content (HP:0009058)	2.92720102
18	Popliteal pterygium (HP:0009756)	2.92549887
19	Exertional dyspnea (HP:0002875)	2.88479361
20	Spastic diplegia (HP:0001264)	2.88126479
21	Rib fusion (HP:0000902)	2.77831251
22	Abnormality of lateral ventricle (HP:0030047)	2.77190048
23	Oligodontia (HP:0000677)	2.74543710
24	Neonatal respiratory distress (HP:0002643)	2.71661567
25	Abnormal number of erythroid precursors (HP:0012131)	2.69947844
26	Hepatic necrosis (HP:0002605)	2.66115709
27	Striae distensae (HP:0001065)	2.64278863
28	Vertebral clefting (HP:0008428)	2.57336917
29	Acute necrotizing encephalopathy (HP:0006965)	2.55929576
30	Increased CSF lactate (HP:0002490)	2.55380331
31	Abnormality of cells of the erythroid lineage (HP:0012130)	2.54302690
32	Abnormal mitochondria in muscle tissue (HP:0008316)	2.52658944
33	Macrocytic anemia (HP:0001972)	2.52507881
34	Increased serum pyruvate (HP:0003542)	2.51563721
35	Maternal diabetes (HP:0009800)	2.49421478
36	Carpal bone hypoplasia (HP:0001498)	2.48539975
37	Chromsome breakage (HP:0040012)	2.45124359
38	Hepatocellular necrosis (HP:0001404)	2.39818971
39	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.36506802
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.36506802
41	Generalized aminoaciduria (HP:0002909)	2.28406245
42	Cortical dysplasia (HP:0002539)	2.26325339
43	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.24257898
44	Cerebellar dysplasia (HP:0007033)	2.23455163
45	Abnormality of glycolysis (HP:0004366)	2.21248793
46	Abnormality of the labia majora (HP:0012881)	2.17534299
47	Bifid tongue (HP:0010297)	2.17141508
48	Shoulder girdle muscle weakness (HP:0003547)	2.16209460
49	Bile duct proliferation (HP:0001408)	2.16073312
50	Abnormal biliary tract physiology (HP:0012439)	2.16073312
51	Abnormality of urine glucose concentration (HP:0011016)	2.14473534
52	Glycosuria (HP:0003076)	2.14473534
53	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.13177290
54	Progressive macrocephaly (HP:0004481)	2.12862079
55	Partial duplication of thumb phalanx (HP:0009944)	2.08526415
56	Delayed CNS myelination (HP:0002188)	2.07957862
57	Tubulointerstitial nephritis (HP:0001970)	2.07163918
58	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.05513157
59	Pallor (HP:0000980)	2.04605215
60	Respiratory difficulties (HP:0002880)	2.02867260
61	Poor head control (HP:0002421)	2.00799171
62	Hypoplasia of the pons (HP:0012110)	11.7164223
63	Abnormality of the pons (HP:0007361)	10.5446007
64	Acute encephalopathy (HP:0006846)	1.99741978
65	Nausea (HP:0002018)	1.99662549
66	Type II lissencephaly (HP:0007260)	1.98688593
67	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.97341930
68	Calcaneovalgus deformity (HP:0001848)	1.94014230
69	Rectal fistula (HP:0100590)	1.93817916
70	Rectovaginal fistula (HP:0000143)	1.93817916
71	Microvesicular hepatic steatosis (HP:0001414)	1.93431301
72	Overlapping toe (HP:0001845)	1.93326003
73	Abnormality of the phalanges of the hallux (HP:0010057)	1.93101246
74	Pelvic girdle muscle weakness (HP:0003749)	1.91587389
75	Hypoplastic heart (HP:0001961)	1.89850915
76	Abnormality of renal resorption (HP:0011038)	1.86024784
77	Abdominal situs inversus (HP:0003363)	1.85321990
78	Abnormality of abdominal situs (HP:0011620)	1.85321990
79	Molar tooth sign on MRI (HP:0002419)	1.81085325
80	Abnormality of midbrain morphology (HP:0002418)	1.81085325
81	Woolly hair (HP:0002224)	1.81037212
82	Pachygyria (HP:0001302)	1.79242890
83	Abnormality of the labia (HP:0000058)	1.78692796
84	Leukodystrophy (HP:0002415)	1.77531086
85	Degeneration of anterior horn cells (HP:0002398)	1.76839472
86	Abnormality of the anterior horn cell (HP:0006802)	1.76839472
87	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.75297489
88	Abnormality of alanine metabolism (HP:0010916)	1.75297489
89	Hyperalaninemia (HP:0003348)	1.75297489
90	Short middle phalanx of the 5th finger (HP:0004220)	1.75148879
91	Increased serum lactate (HP:0002151)	1.74683562
92	Lactic acidosis (HP:0003128)	1.73912449
93	Cerebral edema (HP:0002181)	1.73400089
94	IgM deficiency (HP:0002850)	1.71756015
95	Chin dimple (HP:0010751)	1.71687774
96	Abnormality of the labia minora (HP:0012880)	1.70734141
97	Growth hormone deficiency (HP:0000824)	1.69350046
98	Deformed tarsal bones (HP:0008119)	1.69181462
99	Hyperphosphaturia (HP:0003109)	1.66875021
100	Anophthalmia (HP:0000528)	1.66684065

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	6.43517096
2	KIT	5.51333106
3	TAOK3	3.36484146
4	PLK4	3.23102702
5	CDK19	3.03166350
6	BCKDK	2.89792116
7	VRK2	2.74474324
8	CCNB1	2.58236129
9	BRSK2	2.56440011
10	EIF2AK3	2.50018310
11	MKNK1	2.41016495
12	VRK1	2.35729664
13	BCR	2.12041838
14	TLK1	2.08080524
15	NME1	1.82187658
16	WNK3	1.76722452
17	TAF1	1.75075341
18	PLK3	1.68830878
19	MAP3K4	1.60634971
20	STK16	1.58995202
21	EPHA4	1.57980759
22	MAP3K12	1.54620260
23	PNCK	1.45323836
24	PASK	1.44050183
25	CAMKK2	1.43727162
26	CDC7	1.43338569
27	CHEK2	1.23722537
28	EPHB2	1.15710053
29	PKN1	1.14302119
30	DYRK2	1.07836384
31	NUAK1	1.06192489
32	BRSK1	1.05016310
33	WEE1	1.04568417
34	LATS1	1.03292144
35	EPHB1	0.97257986
36	DYRK1B	0.96142443
37	CDK3	0.95590262
38	MAP2K4	0.83896690
39	CASK	0.81912919
40	LATS2	0.76724940
41	SYK	0.74144707
42	MAP3K11	0.73418405
43	PRKACB	0.69195804
44	SRPK1	0.67237919
45	NEK2	0.65932735
46	DYRK3	0.65122618
47	AURKB	0.64549156
48	PRKG1	0.62545079
49	TGFBR1	0.60946676
50	STK3	0.59394221
51	UHMK1	0.58702912
52	DAPK2	0.58627992
53	DAPK3	0.58448987
54	MAP2K7	0.56866481
55	EGFR	0.52814076
56	MKNK2	0.52516074
57	ZAK	0.51766783
58	CSNK1G3	0.50562754
59	YES1	0.49326209
60	CSNK1A1	0.48270136
61	NTRK3	0.47752051
62	EIF2AK1	0.47578414
63	MAP3K10	0.47533228
64	CSNK1E	0.46613882
65	CSF1R	0.45180693
66	PAK3	0.44260245
67	MAP4K2	0.43300049
68	CSNK1G2	0.43250532
69	TTK	0.42712244
70	MARK3	0.41659839
71	CSNK1G1	0.41235531
72	AURKA	0.40519381
73	CSNK2A2	0.40148671
74	MATK	0.39533507
75	RPS6KA5	0.39019021
76	MAPKAPK5	0.38349207
77	ERBB2	0.38116606
78	MAPK15	0.36091221
79	CSNK2A1	0.36045292
80	CAMK1D	0.36027266
81	EIF2AK2	0.35575141
82	PLK2	0.34401341
83	PIM1	0.34185511
84	OXSR1	0.30642735
85	CAMK2B	0.29920495
86	WNK4	0.29044885
87	PBK	0.28318025
88	CDK4	0.27317333
89	CAMK1	0.27134118
90	PRKCG	0.26039101
91	PTK6	0.25780088
92	STK38L	0.25562936
93	INSRR	0.25506206
94	CSNK1A1L	0.24733633
95	PRKACA	0.24573648
96	ATM	0.20395748
97	PIK3CG	0.19492075
98	PAK4	0.17749850
99	ATR	0.16675966
100	MAP2K3	0.16134173

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.09460480
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.97224531
3	Parkinsons disease_Homo sapiens_hsa05012	3.69845053
4	Proteasome_Homo sapiens_hsa03050	3.63502265
5	Homologous recombination_Homo sapiens_hsa03440	3.01339767
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.01001520
7	Sulfur relay system_Homo sapiens_hsa04122	2.95909232
8	Protein export_Homo sapiens_hsa03060	2.73689394
9	Huntingtons disease_Homo sapiens_hsa05016	2.69099050
10	Folate biosynthesis_Homo sapiens_hsa00790	2.47366413
11	Mismatch repair_Homo sapiens_hsa03430	2.30604150
12	Alzheimers disease_Homo sapiens_hsa05010	2.27777863
13	Asthma_Homo sapiens_hsa05310	2.27627166
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.10907134
15	Basal cell carcinoma_Homo sapiens_hsa05217	2.02884662
16	RNA polymerase_Homo sapiens_hsa03020	1.93237309
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.86183960
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.86137275
19	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.75605860
20	Spliceosome_Homo sapiens_hsa03040	1.67823352
21	DNA replication_Homo sapiens_hsa03030	1.60361133
22	Basal transcription factors_Homo sapiens_hsa03022	1.58057992
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.38943680
24	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.36074788
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.33655035
26	Phototransduction_Homo sapiens_hsa04744	1.31139669
27	Butanoate metabolism_Homo sapiens_hsa00650	1.25792090
28	One carbon pool by folate_Homo sapiens_hsa00670	1.22476061
29	RNA degradation_Homo sapiens_hsa03018	1.19952994
30	Allograft rejection_Homo sapiens_hsa05330	1.16770527
31	RNA transport_Homo sapiens_hsa03013	1.16614786
32	Steroid biosynthesis_Homo sapiens_hsa00100	1.15220006
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.13444188
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.10270655
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.05667424
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05484135
37	Non-homologous end-joining_Homo sapiens_hsa03450	0.98618508
38	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89829993
39	Base excision repair_Homo sapiens_hsa03410	0.87908058
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.86638706
41	Glutathione metabolism_Homo sapiens_hsa00480	0.86250901
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83053015
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82013152
44	Sulfur metabolism_Homo sapiens_hsa00920	0.79817510
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79556042
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78220324
47	Hippo signaling pathway_Homo sapiens_hsa04390	0.77915407
48	Cell cycle_Homo sapiens_hsa04110	0.76331594
49	Nicotine addiction_Homo sapiens_hsa05033	0.73139211
50	mRNA surveillance pathway_Homo sapiens_hsa03015	0.72488237
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71140428
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70993935
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70730766
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69389289
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.63679758
56	Purine metabolism_Homo sapiens_hsa00230	0.62602910
57	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.62480247
58	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.61021371
59	Fatty acid elongation_Homo sapiens_hsa00062	0.60521763
60	Melanogenesis_Homo sapiens_hsa04916	0.59748802
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.58765939
62	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.57745899
63	Alcoholism_Homo sapiens_hsa05034	0.54706701
64	Antigen processing and presentation_Homo sapiens_hsa04612	0.50576408
65	ABC transporters_Homo sapiens_hsa02010	0.50140904
66	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.50100159
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49171633
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.47688105
69	Wnt signaling pathway_Homo sapiens_hsa04310	0.46589120
70	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.46398617
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46062234
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44882734
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42343894
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.41830513
75	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.36549368
76	Peroxisome_Homo sapiens_hsa04146	0.35945437
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34684387
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.34636428
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34517449
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.33701998
81	Oocyte meiosis_Homo sapiens_hsa04114	0.33417138
82	Regulation of autophagy_Homo sapiens_hsa04140	0.31974645
83	Viral myocarditis_Homo sapiens_hsa05416	0.31312713
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30387105
85	Metabolic pathways_Homo sapiens_hsa01100	0.29792641
86	Taste transduction_Homo sapiens_hsa04742	0.28591550
87	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.26933577
88	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.26201485
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.26143827
90	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.25700743
91	HTLV-I infection_Homo sapiens_hsa05166	0.24067436
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.24043914
93	GABAergic synapse_Homo sapiens_hsa04727	0.23161384
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.22789593
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22036298
96	Olfactory transduction_Homo sapiens_hsa04740	0.19370311
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.18515880
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.17778821
99	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.16628128
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.16553923

FKBP4P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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