FKBP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* piRNA metabolic process (GO:0034587)9.78517192
2synaptonemal complex assembly (GO:0007130)8.41826798
3* DNA methylation involved in gamete generation (GO:0043046)8.15170837
4synaptonemal complex organization (GO:0070193)7.74582100
5regulation of meiosis I (GO:0060631)7.56356349
6male meiosis (GO:0007140)6.89618335
7histone H3-K9 demethylation (GO:0033169)6.52959325
8chromosome organization involved in meiosis (GO:0070192)6.25973004
9* meiotic nuclear division (GO:0007126)6.12563031
10male meiosis I (GO:0007141)5.91722911
11histone H3-K36 demethylation (GO:0070544)5.59099535
12meiosis I (GO:0007127)5.26126866
13meiotic chromosome segregation (GO:0045132)5.03429523
14cilium or flagellum-dependent cell motility (GO:0001539)4.91503669
15meiotic cell cycle process (GO:1903046)4.87998887
16reciprocal meiotic recombination (GO:0007131)4.80134861
17reciprocal DNA recombination (GO:0035825)4.80134861
18DNA replication checkpoint (GO:0000076)4.71267242
19regulation of meiotic cell cycle (GO:0051445)4.66702123
20oogenesis (GO:0048477)4.64452850
21attachment of spindle microtubules to kinetochore (GO:0008608)4.51322670
22spermatid development (GO:0007286)4.50450323
23negative regulation of gene silencing (GO:0060969)4.40583125
24negative regulation of meiosis (GO:0045835)4.35875562
25nuclear pore organization (GO:0006999)4.35755171
26mitotic metaphase plate congression (GO:0007080)4.23022547
27protein K6-linked ubiquitination (GO:0085020)4.13326497
28DNA synthesis involved in DNA repair (GO:0000731)4.11225374
29* gene silencing by RNA (GO:0031047)4.09491689
30regulation of double-strand break repair via homologous recombination (GO:0010569)4.07832786
31embryonic body morphogenesis (GO:0010172)4.05647544
32positive regulation of meiosis (GO:0045836)4.04043180
33* DNA methylation (GO:0006306)4.03717448
34* DNA alkylation (GO:0006305)4.03717448
35kinetochore organization (GO:0051383)4.03493293
36kinetochore assembly (GO:0051382)4.01753173
37DNA replication-dependent nucleosome organization (GO:0034723)3.96139806
38DNA replication-dependent nucleosome assembly (GO:0006335)3.96139806
39nuclear pore complex assembly (GO:0051292)3.95489950
40binding of sperm to zona pellucida (GO:0007339)3.93261169
41regulation of meiosis (GO:0040020)3.93170046
42metaphase plate congression (GO:0051310)3.87583762
43positive regulation of meiotic cell cycle (GO:0051446)3.85387497
44mitotic chromosome condensation (GO:0007076)3.82419915
45fertilization (GO:0009566)3.79027278
46synapsis (GO:0007129)3.77103419
47sister chromatid cohesion (GO:0007062)3.72307067
48resolution of meiotic recombination intermediates (GO:0000712)3.71449179
49regulation of acrosome reaction (GO:0060046)3.70330686
50oocyte maturation (GO:0001556)3.69444580
51positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.63728350
52chromatin remodeling at centromere (GO:0031055)3.63496208
53female gamete generation (GO:0007292)3.62089864
54regulation of transcription from RNA polymerase I promoter (GO:0006356)3.61708917
55mitotic spindle assembly checkpoint (GO:0007094)3.61427860
56negative regulation of chromosome segregation (GO:0051985)3.60746148
57DNA replication initiation (GO:0006270)3.57695781
58spindle assembly checkpoint (GO:0071173)3.56464865
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.55989335
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.55989335
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.55989335
62negative regulation of sister chromatid segregation (GO:0033046)3.55989335
63mitotic spindle checkpoint (GO:0071174)3.55467035
64heterochromatin organization (GO:0070828)3.55149682
65genitalia morphogenesis (GO:0035112)3.54032784
66protein localization to chromosome (GO:0034502)3.52822287
67DNA strand elongation involved in DNA replication (GO:0006271)3.51806393
68fusion of sperm to egg plasma membrane (GO:0007342)3.51348685
69purine nucleobase biosynthetic process (GO:0009113)3.50278948
70regulation of DNA endoreduplication (GO:0032875)3.49645513
71spindle checkpoint (GO:0031577)3.48981586
72ribosome biogenesis (GO:0042254)3.48802866
73germ cell development (GO:0007281)3.48144681
74negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.45514211
75negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.43727116
76sperm-egg recognition (GO:0035036)3.43214092
77regulation of chromosome segregation (GO:0051983)3.42229026
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.41480908
79interkinetic nuclear migration (GO:0022027)3.41370805
80formation of translation preinitiation complex (GO:0001731)3.38945592
81histone H4-K12 acetylation (GO:0043983)3.38650297
82regulation of posttranscriptional gene silencing (GO:0060147)3.38280555
83regulation of gene silencing by miRNA (GO:0060964)3.38280555
84regulation of gene silencing by RNA (GO:0060966)3.38280555
85histone exchange (GO:0043486)3.35477665
86mitotic nuclear envelope disassembly (GO:0007077)3.34783268
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.33716231
88proteasome assembly (GO:0043248)3.33699227
89telomere maintenance via semi-conservative replication (GO:0032201)3.32234906
90DNA strand elongation (GO:0022616)3.31785218
91nucleobase biosynthetic process (GO:0046112)3.29905053
92* DNA methylation or demethylation (GO:0044728)3.28874487
93positive regulation of translational initiation (GO:0045948)3.28639923
94regulation of sister chromatid segregation (GO:0033045)3.28260948
95regulation of mitotic sister chromatid separation (GO:0010965)3.28260948
96regulation of mitotic sister chromatid segregation (GO:0033047)3.28260948
97DNA biosynthetic process (GO:0071897)3.26416304
98maturation of SSU-rRNA (GO:0030490)3.25770530
99DNA replication-independent nucleosome assembly (GO:0006336)3.24919528
100DNA replication-independent nucleosome organization (GO:0034724)3.24919528
101telomere maintenance via recombination (GO:0000722)3.24027890
102positive regulation of response to oxidative stress (GO:1902884)3.22851287
103positive regulation of cellular response to oxidative stress (GO:1900409)3.22851287
104sex differentiation (GO:0007548)3.22646373
105CENP-A containing nucleosome assembly (GO:0034080)3.22369747
106regulation of nuclear cell cycle DNA replication (GO:0033262)3.21172229
107histone lysine demethylation (GO:0070076)3.19322687
108protein localization to kinetochore (GO:0034501)3.18823689
109mitotic recombination (GO:0006312)3.18219009
110pore complex assembly (GO:0046931)3.18009654
111regulation of cytokine production involved in inflammatory response (GO:1900015)3.15159292
112* male gamete generation (GO:0048232)3.13619285
113* spermatogenesis (GO:0007283)3.13430806
114membrane disassembly (GO:0030397)3.13102588
115nuclear envelope disassembly (GO:0051081)3.13102588
116* gamete generation (GO:0007276)3.11928939
117ribosome assembly (GO:0042255)3.11784051
118histone demethylation (GO:0016577)3.11048896
119chromosome organization (GO:0051276)3.10201135
120meiotic cell cycle (GO:0051321)3.09951171
121epithelial cilium movement (GO:0003351)3.09100516
122negative regulation of inclusion body assembly (GO:0090084)3.08953532
123negative regulation of nuclear division (GO:0051784)3.08906538
124regulation of histone H3-K9 methylation (GO:0051570)3.08302037
125body morphogenesis (GO:0010171)3.07880955
126regulation of double-strand break repair (GO:2000779)3.07104251
127negative regulation of cell aging (GO:0090344)3.06942022
128histone H2A acetylation (GO:0043968)3.06938587
129epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05921357
130* gene silencing (GO:0016458)3.05328218
131cellular process involved in reproduction in multicellular organism (GO:0022412)3.04529204
132regulation of microtubule-based movement (GO:0060632)3.04089330
133snRNA processing (GO:0016180)3.03183597
134inner cell mass cell proliferation (GO:0001833)3.03125836
135DNA packaging (GO:0006323)3.01979932
136establishment of chromosome localization (GO:0051303)3.01147028
137acrosome reaction (GO:0007340)3.00411643
138oocyte development (GO:0048599)3.00367708
139positive regulation of chromosome segregation (GO:0051984)3.00207301
140centriole assembly (GO:0098534)3.00191232
141mismatch repair (GO:0006298)2.97055877
142reproductive system development (GO:0061458)2.94110157
143multicellular organism reproduction (GO:0032504)2.93239028
144sperm motility (GO:0030317)2.93155605
145* nuclear division (GO:0000280)2.92350534
146regulation of chromatin silencing (GO:0031935)2.91886969
147nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.88280658
148protein dealkylation (GO:0008214)2.87106886
149protein demethylation (GO:0006482)2.87106886
150cell-cell recognition (GO:0009988)2.84685313
151acrosome assembly (GO:0001675)2.81100740
152* organelle fission (GO:0048285)2.72094942
153centriole replication (GO:0007099)2.67735455
154cilium movement (GO:0003341)2.67091640
155positive regulation of gene expression, epigenetic (GO:0045815)2.64385187
156plasma membrane fusion (GO:0045026)2.64339406
157positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.63062360
158positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.63062360
159positive regulation of mitotic sister chromatid separation (GO:1901970)2.63062360
160axoneme assembly (GO:0035082)2.62496892
161mitotic sister chromatid cohesion (GO:0007064)2.61596529
162axonemal dynein complex assembly (GO:0070286)2.61571948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.11773449
2EZH2_22144423_ChIP-Seq_EOC_Human5.08613414
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.45594039
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.97624645
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.83527393
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56835320
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.39883267
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10236035
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97593850
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85059146
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83935514
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78880454
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.70029008
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.68873111
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63549202
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.61644374
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61636314
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.58981685
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53812957
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.49426566
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.49426566
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.49426566
23AR_21909140_ChIP-Seq_LNCAP_Human2.47407970
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46755711
25YY1_22570637_ChIP-Seq_MALME-3M_Human2.38509215
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33954475
27RNF2_27304074_Chip-Seq_NSC_Mouse2.32742810
28ERA_21632823_ChIP-Seq_H3396_Human2.28814628
29* P68_20966046_ChIP-Seq_HELA_Human2.28203385
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.27054568
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.25066129
32E2F1_20622854_ChIP-Seq_HELA_Human2.22617160
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16915173
34E2F1_21310950_ChIP-Seq_MCF-7_Human2.14872562
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13447138
36VDR_23849224_ChIP-Seq_CD4+_Human2.05922210
37BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04985300
38BCL6_27268052_Chip-Seq_Bcells_Human2.02676938
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02478421
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98528190
41XRN2_22483619_ChIP-Seq_HELA_Human1.97939573
42PHF8_20622854_ChIP-Seq_HELA_Human1.96476537
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95197800
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93435845
45DCP1A_22483619_ChIP-Seq_HELA_Human1.92208286
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85480906
47BCOR_27268052_Chip-Seq_Bcells_Human1.85042471
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81567654
49ZNF274_21170338_ChIP-Seq_K562_Hela1.79539572
50GABP_19822575_ChIP-Seq_HepG2_Human1.78621491
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77909530
52IGF1R_20145208_ChIP-Seq_DFB_Human1.77674832
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72571773
54TP53_22573176_ChIP-Seq_HFKS_Human1.69108028
55* YY1_21170310_ChIP-Seq_MESCs_Mouse1.68678263
56FOXP3_21729870_ChIP-Seq_TREG_Human1.68358269
57VDR_21846776_ChIP-Seq_THP-1_Human1.65393197
58* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62758490
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61312514
60KDM5A_27292631_Chip-Seq_BREAST_Human1.58953680
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58563187
62FUS_26573619_Chip-Seq_HEK293_Human1.58436562
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.58378255
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.58202083
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.57388015
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54722752
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52606940
68TTF2_22483619_ChIP-Seq_HELA_Human1.52473116
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51004331
70* SMC4_20622854_ChIP-Seq_HELA_Human1.47520692
71MYC_19829295_ChIP-Seq_ESCs_Human1.46777410
72OCT4_20526341_ChIP-Seq_ESCs_Human1.46205114
73SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45729236
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44468094
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44348829
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43109672
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40044788
78RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.38869299
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38858001
80MAF_26560356_Chip-Seq_TH2_Human1.36365717
81ER_23166858_ChIP-Seq_MCF-7_Human1.35139810
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34675750
83SOX2_21211035_ChIP-Seq_LN229_Human1.33977063
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.33186710
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30377973
86CIITA_25753668_ChIP-Seq_RAJI_Human1.30218688
87RAC3_21632823_ChIP-Seq_H3396_Human1.27179735
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24586273
89TFEB_21752829_ChIP-Seq_HELA_Human1.24046185
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23697129
91NANOG_20526341_ChIP-Seq_ESCs_Human1.23326447
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.22528376
93RARA_24833708_ChIP-Seq_LIVER_Mouse1.21671211
94P300_27268052_Chip-Seq_Bcells_Human1.21237862
95BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.21029741
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20083809
97* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19144769
98EWS_26573619_Chip-Seq_HEK293_Human1.18498666
99TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18320104
100ELK1_19687146_ChIP-ChIP_HELA_Human1.18187707
101RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18121638
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16415705
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15348818
104MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14295816
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13742034
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13561430
107CTCF_20526341_ChIP-Seq_ESCs_Human1.13523550
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13509521
109FOXH1_21741376_ChIP-Seq_EPCs_Human1.12764631
110RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11941485
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11480956
112TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10334527
113GATA3_26560356_Chip-Seq_TH1_Human1.09031473
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08233566
115EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08087283
116SRF_21415370_ChIP-Seq_HL-1_Mouse1.06883776
117BCAT_22108803_ChIP-Seq_LS180_Human1.06774255
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06540193
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06335044
120HOXB7_26014856_ChIP-Seq_BT474_Human1.05671372
121* OCT4_19829295_ChIP-Seq_ESCs_Human1.05660918
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05535349
123P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.05244955
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03893710
125SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03218254
126CTCF_21964334_Chip-Seq_Bcells_Human1.02934104
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02562523
128CTCF_27219007_Chip-Seq_Bcells_Human1.01533529
129SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01092565
130STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00835152
131P53_21459846_ChIP-Seq_SAOS-2_Human1.00296217
132VDR_22108803_ChIP-Seq_LS180_Human1.00190419
133CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99882531
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99815506
135* TAF2_19829295_ChIP-Seq_ESCs_Human0.98450053
136FOXP1_21924763_ChIP-Seq_HESCs_Human0.97932321
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97823949
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.97670068
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97550022
140SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97323283
141GATA1_26923725_Chip-Seq_HPCs_Mouse0.95710904
142CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95297746
143E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95260287
144HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95093304
145GATA3_21878914_ChIP-Seq_MCF-7_Human0.94266731
146RUNX2_22187159_ChIP-Seq_PCA_Human0.93624640
147CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92978178
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92635279
149RARB_24833708_ChIP-Seq_LIVER_Mouse0.92518177
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92427594
151ETS1_21867929_ChIP-Seq_TH2_Mouse0.91295332
152NANOG_21062744_ChIP-ChIP_HESCs_Human0.89616122
153MYC_18940864_ChIP-ChIP_HL60_Human0.86021482
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85944602
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85750064
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.83511862
157SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83253279
158TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81179657
159NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80717545
160SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76990492
161CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76593881
162PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74445427
163KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74179831
164POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.71996054
165TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71944474
166ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69189479
167EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.68788747
168TCF3_18692474_ChIP-Seq_MESCs_Mouse0.67815728
169SOX2_18692474_ChIP-Seq_MESCs_Mouse0.67401244
170ELF1_17652178_ChIP-ChIP_JURKAT_Human0.66639453
171TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64597338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.62058562
2MP0008995_early_reproductive_senescence4.75607500
3MP0010094_abnormal_chromosome_stability4.46612635
4MP0003693_abnormal_embryo_hatching4.08277532
5MP0003111_abnormal_nucleus_morphology3.94155006
6MP0008058_abnormal_DNA_repair3.90212624
7MP0001986_abnormal_taste_sensitivity3.83024171
8MP0003786_premature_aging3.79488997
9MP0005174_abnormal_tail_pigmentation3.59548947
10* MP0002210_abnormal_sex_determination3.53150521
11MP0008057_abnormal_DNA_replication3.43246245
12MP0004957_abnormal_blastocyst_morpholog3.41967391
13MP0003077_abnormal_cell_cycle3.05774611
14* MP0001929_abnormal_gametogenesis2.97456340
15* MP0001145_abnormal_male_reproductive2.88314920
16MP0005409_darkened_coat_color2.83400130
17MP0005423_abnormal_somatic_nervous2.69340782
18MP0005377_hearing/vestibular/ear_phenot2.62197296
19MP0003878_abnormal_ear_physiology2.62197296
20MP0003123_paternal_imprinting2.53993950
21* MP0000653_abnormal_sex_gland2.53366883
22* MP0003698_abnormal_male_reproductive2.34518332
23MP0008932_abnormal_embryonic_tissue2.15935428
24MP0001188_hyperpigmentation2.12427625
25MP0008007_abnormal_cellular_replicative2.11971301
26MP0000678_abnormal_parathyroid_gland2.04007053
27MP0005171_absent_coat_pigmentation1.96613053
28MP0003718_maternal_effect1.93293733
29MP0001730_embryonic_growth_arrest1.89113254
30MP0000372_irregular_coat_pigmentation1.85723511
31MP0008789_abnormal_olfactory_epithelium1.69854878
32MP0000383_abnormal_hair_follicle1.68499921
33MP0003136_yellow_coat_color1.62297235
34MP0000350_abnormal_cell_proliferation1.61689503
35MP0000427_abnormal_hair_cycle1.60229741
36MP0003941_abnormal_skin_development1.56565278
37MP0001119_abnormal_female_reproductive1.47427026
38MP0003315_abnormal_perineum_morphology1.46862841
39* MP0002161_abnormal_fertility/fecundity1.44320964
40MP0010678_abnormal_skin_adnexa1.44148158
41MP0010352_gastrointestinal_tract_polyps1.40804541
42MP0002160_abnormal_reproductive_system1.38645129
43MP0003890_abnormal_embryonic-extraembry1.38089500
44MP0010307_abnormal_tumor_latency1.37679985
45MP0008260_abnormal_autophagy1.36094341
46MP0005410_abnormal_fertilization1.32667525
47MP0005380_embryogenesis_phenotype1.29412868
48MP0001672_abnormal_embryogenesis/_devel1.29412868
49MP0001502_abnormal_circadian_rhythm1.23173840
50MP0001697_abnormal_embryo_size1.18821516
51MP0002085_abnormal_embryonic_tissue1.15738880
52MP0005408_hypopigmentation1.13676217
53MP0005394_taste/olfaction_phenotype1.10969991
54MP0005499_abnormal_olfactory_system1.10969991
55MP0003984_embryonic_growth_retardation1.10386134
56MP0000313_abnormal_cell_death1.07323870
57MP0003699_abnormal_female_reproductive1.07281647
58MP0003121_genomic_imprinting1.06823118
59MP0004197_abnormal_fetal_growth/weight/1.06455721
60MP0000569_abnormal_digit_pigmentation1.05524774
61MP0002088_abnormal_embryonic_growth/wei1.05104095
62MP0002080_prenatal_lethality1.04763637
63MP0002084_abnormal_developmental_patter1.03296957
64MP0002638_abnormal_pupillary_reflex1.02732156
65MP0000371_diluted_coat_color1.01757145
66MP0005389_reproductive_system_phenotype0.99941857
67MP0008004_abnormal_stomach_pH0.99308485
68MP0003936_abnormal_reproductive_system0.95335731
69MP0008875_abnormal_xenobiotic_pharmacok0.93712176
70MP0002086_abnormal_extraembryonic_tissu0.92318673
71MP0001293_anophthalmia0.91995122
72MP0003943_abnormal_hepatobiliary_system0.90998510
73MP0009379_abnormal_foot_pigmentation0.90373033
74MP0004808_abnormal_hematopoietic_stem0.90216634
75MP0002019_abnormal_tumor_incidence0.89746937
76MP0004019_abnormal_vitamin_homeostasis0.89590401
77MP0002928_abnormal_bile_duct0.86639931
78MP0002075_abnormal_coat/hair_pigmentati0.84757812
79MP0005551_abnormal_eye_electrophysiolog0.84585610
80MP0001661_extended_life_span0.83643588
81MP0001968_abnormal_touch/_nociception0.83059045
82MP0003119_abnormal_digestive_system0.81438776
83MP0003567_abnormal_fetal_cardiomyocyte0.80755743
84MP0002653_abnormal_ependyma_morphology0.80595724
85MP0002102_abnormal_ear_morphology0.77801088
86MP0000013_abnormal_adipose_tissue0.76844998
87MP0003646_muscle_fatigue0.75447587
88MP0001984_abnormal_olfaction0.75063767
89MP0005647_abnormal_sex_gland0.74019020
90MP0006292_abnormal_olfactory_placode0.73232217
91MP0005395_other_phenotype0.72856165
92MP0002139_abnormal_hepatobiliary_system0.72839620
93MP0001727_abnormal_embryo_implantation0.72195409
94MP0002396_abnormal_hematopoietic_system0.68199955
95MP0005076_abnormal_cell_differentiation0.66873684
96MP0001664_abnormal_digestion0.65929509
97MP0001186_pigmentation_phenotype0.65900089
98MP0003787_abnormal_imprinting0.64730936
99MP0006276_abnormal_autonomic_nervous0.63614430
100MP0001324_abnormal_eye_pigmentation0.63372631
101MP0005621_abnormal_cell_physiology0.62582965
102MP0005384_cellular_phenotype0.61700258
103MP0002735_abnormal_chemical_nociception0.60670826
104MP0003453_abnormal_keratinocyte_physiol0.60266196
105MP0003221_abnormal_cardiomyocyte_apopto0.59945323
106MP0009672_abnormal_birth_weight0.59865268
107MP0000358_abnormal_cell_content/0.59330293
108MP0005365_abnormal_bile_salt0.57806401
109MP0000778_abnormal_nervous_system0.55824927
110MP0003879_abnormal_hair_cell0.55146032
111MP0009703_decreased_birth_body0.54789525
112MP0001919_abnormal_reproductive_system0.53846764
113MP0003937_abnormal_limbs/digits/tail_de0.53440440
114MP0005623_abnormal_meninges_morphology0.53010862
115MP0004381_abnormal_hair_follicle0.50955763
116MP0002736_abnormal_nociception_after0.50529131
117MP0000516_abnormal_urinary_system0.49497161
118MP0005367_renal/urinary_system_phenotyp0.49497161
119MP0003183_abnormal_peptide_metabolism0.49312004
120MP0000470_abnormal_stomach_morphology0.49187234
121MP0000631_abnormal_neuroendocrine_gland0.47714848
122MP0005075_abnormal_melanosome_morpholog0.47473442
123MP0005397_hematopoietic_system_phenotyp0.46696568
124MP0001545_abnormal_hematopoietic_system0.46696568
125MP0001765_abnormal_ion_homeostasis0.46566075
126MP0002095_abnormal_skin_pigmentation0.45960291
127MP0000015_abnormal_ear_pigmentation0.45838007
128MP0006035_abnormal_mitochondrial_morpho0.44093531
129MP0000537_abnormal_urethra_morphology0.44063643
130MP0002092_abnormal_eye_morphology0.43182962
131MP0002269_muscular_atrophy0.42087146
132MP0002111_abnormal_tail_morphology0.42087137
133MP0000490_abnormal_crypts_of0.42066021
134MP0003186_abnormal_redox_activity0.41176790
135MP0001486_abnormal_startle_reflex0.40978835
136MP0004233_abnormal_muscle_weight0.40557790
137MP0010234_abnormal_vibrissa_follicle0.40126994
138MP0002938_white_spotting0.39655372
139MP0009697_abnormal_copulation0.37222056
140MP0005257_abnormal_intraocular_pressure0.36930868
141MP0001485_abnormal_pinna_reflex0.36476132
142MP0005253_abnormal_eye_physiology0.34585170
143MP0000751_myopathy0.34433105
144MP0001915_intracranial_hemorrhage0.34166020
145MP0005646_abnormal_pituitary_gland0.33604845
146MP0002249_abnormal_larynx_morphology0.32467073

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)7.92784316
2Abnormal spermatogenesis (HP:0008669)7.14520721
3Chromsome breakage (HP:0040012)5.12313819
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.96268449
5Testicular atrophy (HP:0000029)4.67154219
6Spontaneous abortion (HP:0005268)4.41061617
7Gonadotropin excess (HP:0000837)4.01535209
8Birth length less than 3rd percentile (HP:0003561)4.00723480
9Breast hypoplasia (HP:0003187)3.98090761
10Tubulointerstitial nephritis (HP:0001970)3.91173331
11Carpal bone hypoplasia (HP:0001498)3.83409847
12Horizontal nystagmus (HP:0000666)3.80642565
13Oligodactyly (hands) (HP:0001180)3.65836409
14Attenuation of retinal blood vessels (HP:0007843)3.62998711
15Impulsivity (HP:0100710)3.61479820
16Abnormality of the labia minora (HP:0012880)3.53527196
17Meckel diverticulum (HP:0002245)3.45465672
18Abnormality of chromosome stability (HP:0003220)3.41540269
19Absent thumb (HP:0009777)3.40558367
20Absent/shortened dynein arms (HP:0200106)3.37197667
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.37197667
22Abnormality of the ileum (HP:0001549)3.29164706
23Absent radius (HP:0003974)3.25833082
24Abnormality of the lower motor neuron (HP:0002366)3.24296947
25Type I transferrin isoform profile (HP:0003642)3.21201620
26Aplasia/Hypoplasia of the uvula (HP:0010293)3.20368081
27Abnormality of the preputium (HP:0100587)3.18607633
28Volvulus (HP:0002580)3.18007637
29Abnormal protein glycosylation (HP:0012346)3.15515518
30Abnormal glycosylation (HP:0012345)3.15515518
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.15515518
32Abnormal protein N-linked glycosylation (HP:0012347)3.15515518
33Abnormality of the anterior horn cell (HP:0006802)3.07963698
34Degeneration of anterior horn cells (HP:0002398)3.07963698
35Poikiloderma (HP:0001029)3.07557628
36Patellar aplasia (HP:0006443)3.06901201
37Absent forearm bone (HP:0003953)3.06228513
38Aplasia involving forearm bones (HP:0009822)3.06228513
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.04439122
40Infertility (HP:0000789)2.98690474
41Fetal akinesia sequence (HP:0001989)2.98155695
42Ectopic kidney (HP:0000086)2.94985789
43Ependymoma (HP:0002888)2.91000906
4411 pairs of ribs (HP:0000878)2.89621492
45Aplasia/Hypoplasia of the patella (HP:0006498)2.89522356
46Non-midline cleft lip (HP:0100335)2.84452337
47Duplicated collecting system (HP:0000081)2.81442134
48Male infertility (HP:0003251)2.80736640
49Colon cancer (HP:0003003)2.72510475
50Premature ovarian failure (HP:0008209)2.72140892
51Rhabdomyosarcoma (HP:0002859)2.71799840
52Ureteral duplication (HP:0000073)2.70582137
53Supernumerary spleens (HP:0009799)2.69731152
54Lip pit (HP:0100267)2.69310866
55Osteomalacia (HP:0002749)2.68633066
56Enlarged epiphyses (HP:0010580)2.68426258
57Facial hemangioma (HP:0000329)2.68081159
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.67756513
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.67756513
60Medulloblastoma (HP:0002885)2.67554169
61Nephronophthisis (HP:0000090)2.67156148
62Selective tooth agenesis (HP:0001592)2.66830356
63Bony spicule pigmentary retinopathy (HP:0007737)2.65959454
64Duodenal stenosis (HP:0100867)2.60553756
65Small intestinal stenosis (HP:0012848)2.60553756
66Abnormal respiratory epithelium morphology (HP:0012253)2.58658134
67Abnormal respiratory motile cilium morphology (HP:0005938)2.58658134
68Tongue fasciculations (HP:0001308)2.58446616
69Horseshoe kidney (HP:0000085)2.55723664
70Cerebral hypomyelination (HP:0006808)2.52934674
71Rough bone trabeculation (HP:0100670)2.52401921
72Aplasia of the musculature (HP:0100854)2.51940558
73Molar tooth sign on MRI (HP:0002419)2.48405490
74Abnormality of midbrain morphology (HP:0002418)2.48405490
75Aplasia/Hypoplasia of the macula (HP:0008059)2.46688513
76Abnormality of the renal medulla (HP:0100957)2.45218884
77Abnormal ciliary motility (HP:0012262)2.44069612
78Dyschromatopsia (HP:0007641)2.41667449
79Renal Fanconi syndrome (HP:0001994)2.41039019
80Facial cleft (HP:0002006)2.40709174
81Rimmed vacuoles (HP:0003805)2.36694846
82Aplasia/Hypoplasia of the fovea (HP:0008060)2.36581946
83Hypoplasia of the fovea (HP:0007750)2.36581946
84Bone marrow hypocellularity (HP:0005528)2.35827548
85Shawl scrotum (HP:0000049)2.34380885
86Mesangial abnormality (HP:0001966)2.33367747
87Metaphyseal cupping (HP:0003021)2.32872108
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32722592
89Premature graying of hair (HP:0002216)2.32679445
90Spinal muscular atrophy (HP:0007269)2.30441298
91Abnormal respiratory motile cilium physiology (HP:0012261)2.30067801
92Secondary amenorrhea (HP:0000869)2.29466095
93Abnormality of the renal collecting system (HP:0004742)2.29339137
94Abnormality of DNA repair (HP:0003254)2.28489977
95Atrophy/Degeneration involving motor neurons (HP:0007373)2.28212872
96Short thumb (HP:0009778)2.28206093
97Hypophosphatemic rickets (HP:0004912)2.27130620
98Muscle fibrillation (HP:0010546)2.25743210
99Glioma (HP:0009733)2.23196447
100Rib fusion (HP:0000902)2.22471645
101Rectovaginal fistula (HP:0000143)2.19698807
102Rectal fistula (HP:0100590)2.19698807
103Aplasia/Hypoplasia involving the musculature (HP:0001460)2.19579965
104Vaginal fistula (HP:0004320)2.18975606
105Abnormal lung lobation (HP:0002101)2.17825043
106Reticulocytopenia (HP:0001896)2.17400566
107Abnormality of the carotid arteries (HP:0005344)2.17225498
108Male pseudohermaphroditism (HP:0000037)2.16164928
109Shoulder girdle muscle weakness (HP:0003547)2.15138847
110Capillary hemangiomas (HP:0005306)2.14195934
111Sloping forehead (HP:0000340)2.13632922
112Truncal obesity (HP:0001956)2.12884019
113Aplasia/Hypoplasia affecting the retina (HP:0008061)2.11637216
114Oligodactyly (HP:0012165)2.11265956
115Choroideremia (HP:0001139)2.08806397
116Broad distal phalanx of finger (HP:0009836)2.07734467
117Prolonged partial thromboplastin time (HP:0003645)2.06752700
118Agnosia (HP:0010524)2.05570546
119Hypoplasia of the radius (HP:0002984)2.04880930
120Amniotic constriction ring (HP:0009775)2.04805858
121Abnormality of placental membranes (HP:0011409)2.04805858
122Abnormality of homocysteine metabolism (HP:0010919)2.03071785
123Homocystinuria (HP:0002156)2.03071785
124Decreased central vision (HP:0007663)2.02853011
125Neoplasm of the pancreas (HP:0002894)2.02656521
126Abnormality of the astrocytes (HP:0100707)2.01421773
127Astrocytoma (HP:0009592)2.01421773
128Hand muscle atrophy (HP:0009130)2.01276756
129Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00537261
130Abnormality of the duodenum (HP:0002246)1.99740514
131Popliteal pterygium (HP:0009756)1.99740350
132Increased hepatocellular lipid droplets (HP:0006565)1.99565446
133Abnormality of the aortic arch (HP:0012303)1.99019849
134Large hands (HP:0001176)1.98784729
135Hypoplasia of the pons (HP:0012110)1.97059691
136Neoplasm of striated muscle (HP:0009728)1.96837564
137Abnormal biliary tract physiology (HP:0012439)1.93585887
138Bile duct proliferation (HP:0001408)1.93585887
139Delayed epiphyseal ossification (HP:0002663)1.93445431
140Increased nuchal translucency (HP:0010880)1.92852481
141Ankle contracture (HP:0006466)1.92476161
142Triphalangeal thumb (HP:0001199)1.92177138
143Akinesia (HP:0002304)1.91644079
144Aplasia/hypoplasia of the humerus (HP:0006507)1.91442802
145Clubbing of toes (HP:0100760)1.90971021
146Congenital stationary night blindness (HP:0007642)1.90190886
147Abnormality of the corticospinal tract (HP:0002492)1.90039489
148Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89798431
149Long foot (HP:0001833)1.89769361
150Respiratory difficulties (HP:0002880)1.89476839
151Amyotrophic lateral sclerosis (HP:0007354)1.89450344
152Myelodysplasia (HP:0002863)1.88845324
153Squamous cell carcinoma (HP:0002860)1.88472171
154Cleft eyelid (HP:0000625)1.88071638
155Tracheoesophageal fistula (HP:0002575)1.87574962
156Intestinal fistula (HP:0100819)1.86882073
157Gonadal dysgenesis (HP:0000133)1.86567141
158Abnormal trabecular bone morphology (HP:0100671)1.86367589
159Occipital encephalocele (HP:0002085)1.86171559
160Abnormal urine phosphate concentration (HP:0012599)1.85585286
161Abnormal biliary tract morphology (HP:0012440)1.84949189
162Hypopigmentation of the fundus (HP:0007894)1.84582796
163Abnormality of renal resorption (HP:0011038)1.83821749
164Papillary thyroid carcinoma (HP:0002895)1.82339136
165Joint hemorrhage (HP:0005261)1.82270228
166Abnormality of the intrinsic pathway (HP:0010989)1.80122905
167Cafe-au-lait spot (HP:0000957)1.78871668
168Pelvic girdle muscle weakness (HP:0003749)1.78588232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.94394452
2CDK194.77587150
3WEE14.72023755
4CDC74.50960567
5CDK124.03023449
6MAPK153.76058344
7BUB13.68634827
8NEK22.84569099
9TTK2.60080484
10PTK2B2.56181958
11PLK42.54410833
12CAMK1G2.47912576
13PLK12.36651104
14OXSR12.28552912
15PDK42.23134843
16PDK32.23134843
17EPHA22.21547658
18CSF1R2.20829325
19STK38L2.08359743
20TSSK61.99604410
21BRSK21.98018109
22FGR1.95171607
23SRPK11.92910871
24EIF2AK11.87664134
25NEK11.81069550
26ATR1.74561472
27SIK21.74476838
28BRD41.73474114
29CDK71.73338665
30ZAK1.72982771
31PBK1.72585122
32MAP3K131.65984976
33MKNK21.62485874
34CHEK21.57550619
35STK161.53164273
36PLK31.51905120
37NEK61.51139320
38CHEK11.50205612
39PDK21.46276820
40ARAF1.42020992
41RET1.36229927
42AKT31.31099536
43TAOK31.30619095
44AURKB1.29582070
45FRK1.28095699
46BRSK11.27785815
47DYRK31.26148240
48MAP3K91.25061592
49WNK41.22278552
50MST1R1.19665876
51IRAK31.15285675
52MKNK11.15110894
53PNCK1.13524861
54ATM1.13408748
55CDK41.11118153
56EIF2AK31.09703293
57AURKA1.07061645
58NEK91.06655151
59MARK31.04743624
60ICK1.01884425
61STK30.98223491
62CCNB10.98076869
63MELK0.96602136
64WNK10.96556145
65STK40.96461411
66MUSK0.94971657
67CDK60.93234462
68CDK20.92056128
69PDPK10.91583120
70STK240.88244473
71PDGFRB0.87397653
72PTK20.79776200
73PASK0.79621438
74CDK80.79587673
75NUAK10.76752196
76CDK10.74210204
77BRAF0.73204977
78MAPK130.72913325
79PDK10.70249572
80PAK40.70089227
81RAF10.69879110
82FLT30.69077887
83NME10.68836601
84VRK10.68095313
85RPS6KB20.67768249
86MET0.62883516
87PRKCI0.62269994
88PINK10.61540863
89STK110.59953935
90TESK20.59556063
91TYRO30.59301104
92CSNK2A20.58915869
93TLK10.57169619
94EGFR0.56778287
95CSNK2A10.55711693
96TESK10.55275490
97MTOR0.54071414
98CDK30.52335066
99MAP3K80.51213033
100CDK11A0.49551416
101TRIM280.49411821
102MAP2K20.49228438
103ALK0.48551892
104BLK0.47563826
105PIM10.45646859
106NTRK30.44536552
107PRKDC0.44417953
108BCKDK0.43988722
109CSNK1E0.43892587
110PAK10.43787060
111KSR10.43379851
112SGK10.43295116
113EIF2AK20.42989573
114KSR20.42365526
115ADRBK10.41958764
116CAMK10.41854736
117PLK20.40967580
118LATS20.40625393
119SCYL20.38439874
120PRKG10.37466877
121CDK90.37466210
122CASK0.37159885
123MAP3K30.36833729
124WNK30.36808239
125GSK3B0.35869806
126CDK50.34638721
127PRKD30.34152441
128TGFBR10.32974700
129MAPK110.32941039
130PRKCZ0.31934860
131MAP3K50.30383433
132STK390.29658885
133MAP3K20.29506507
134MAP3K40.29332171
135RPS6KA40.28877446
136CSNK1G10.27337717
137ROCK10.26805026
138MOS0.26717558
139BMPR1B0.26386962
140CDC42BPA0.25551316
141CSNK1D0.25530319
142MAPK140.25442670
143MAP4K20.24835159
144MAPK10.24407139
145ADRBK20.22372335
146BCR0.21935215
147DYRK1A0.21091557
148MAPKAPK30.20470530
149MAPK80.20205255
150DYRK20.18990678
151BMX0.18919888
152STK380.18839238
153RPS6KA50.16790749
154CHUK0.15834437
155RPS6KB10.15542339
156AKT10.15188262
157CLK10.14122784

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.15897342
2Sulfur relay system_Homo sapiens_hsa041224.80411756
3DNA replication_Homo sapiens_hsa030304.20547317
4Mismatch repair_Homo sapiens_hsa034303.97499357
5Proteasome_Homo sapiens_hsa030503.92510814
6RNA polymerase_Homo sapiens_hsa030203.77270756
7Homologous recombination_Homo sapiens_hsa034403.72580042
8Basal transcription factors_Homo sapiens_hsa030223.69438506
9RNA transport_Homo sapiens_hsa030133.41401610
10Fanconi anemia pathway_Homo sapiens_hsa034602.98898678
11Nucleotide excision repair_Homo sapiens_hsa034202.93713050
12Cell cycle_Homo sapiens_hsa041102.91268853
13Spliceosome_Homo sapiens_hsa030402.88104578
14Base excision repair_Homo sapiens_hsa034102.61997964
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40333551
16mRNA surveillance pathway_Homo sapiens_hsa030152.33615223
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.23425153
18Pyrimidine metabolism_Homo sapiens_hsa002402.19907159
19Non-homologous end-joining_Homo sapiens_hsa034502.19628276
20One carbon pool by folate_Homo sapiens_hsa006702.15153644
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.10276342
22Vitamin B6 metabolism_Homo sapiens_hsa007501.90952170
23RNA degradation_Homo sapiens_hsa030181.77503404
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55099392
25p53 signaling pathway_Homo sapiens_hsa041151.51806724
26Oocyte meiosis_Homo sapiens_hsa041141.51692427
27Selenocompound metabolism_Homo sapiens_hsa004501.47837866
28Purine metabolism_Homo sapiens_hsa002301.36052709
29Ribosome_Homo sapiens_hsa030101.35668142
30Taste transduction_Homo sapiens_hsa047421.32487908
31Phototransduction_Homo sapiens_hsa047441.28987710
32Epstein-Barr virus infection_Homo sapiens_hsa051691.26245529
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13324180
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12547874
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02435369
36Herpes simplex infection_Homo sapiens_hsa051681.01233870
37N-Glycan biosynthesis_Homo sapiens_hsa005101.00165612
38Regulation of autophagy_Homo sapiens_hsa041400.99808235
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97996102
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97108898
41Calcium signaling pathway_Homo sapiens_hsa040200.94943583
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93745155
43ABC transporters_Homo sapiens_hsa020100.91361169
44Ovarian steroidogenesis_Homo sapiens_hsa049130.89974444
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88152255
46Pentose phosphate pathway_Homo sapiens_hsa000300.86736727
47Olfactory transduction_Homo sapiens_hsa047400.81058982
48Folate biosynthesis_Homo sapiens_hsa007900.74747935
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.72743899
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.71874190
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71108588
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.69286049
53Sphingolipid metabolism_Homo sapiens_hsa006000.68246993
54Huntingtons disease_Homo sapiens_hsa050160.66343235
55Propanoate metabolism_Homo sapiens_hsa006400.61707414
56Phenylalanine metabolism_Homo sapiens_hsa003600.61375210
57Dorso-ventral axis formation_Homo sapiens_hsa043200.59029020
58Biosynthesis of amino acids_Homo sapiens_hsa012300.56473394
59HTLV-I infection_Homo sapiens_hsa051660.55690022
60Viral carcinogenesis_Homo sapiens_hsa052030.53872765
61Nicotine addiction_Homo sapiens_hsa050330.53041733
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52866496
63Linoleic acid metabolism_Homo sapiens_hsa005910.52793416
64Fructose and mannose metabolism_Homo sapiens_hsa000510.52456081
65Vitamin digestion and absorption_Homo sapiens_hsa049770.51958368
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.51283239
67Pyruvate metabolism_Homo sapiens_hsa006200.49583551
68Thyroid cancer_Homo sapiens_hsa052160.45585071
69ErbB signaling pathway_Homo sapiens_hsa040120.45175293
70Caffeine metabolism_Homo sapiens_hsa002320.44023066
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43521511
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42267468
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42238660
74TGF-beta signaling pathway_Homo sapiens_hsa043500.41826650
75Antigen processing and presentation_Homo sapiens_hsa046120.41799574
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41617041
77Retinol metabolism_Homo sapiens_hsa008300.38939287
78Influenza A_Homo sapiens_hsa051640.38315741
79Glutathione metabolism_Homo sapiens_hsa004800.38059808
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37427234
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.37315035
82VEGF signaling pathway_Homo sapiens_hsa043700.36988109
83Hippo signaling pathway_Homo sapiens_hsa043900.33427552
84MAPK signaling pathway_Homo sapiens_hsa040100.33034854
85Notch signaling pathway_Homo sapiens_hsa043300.32024350
86Lysine degradation_Homo sapiens_hsa003100.30794933
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30363080
88Glycerolipid metabolism_Homo sapiens_hsa005610.29948541
89Legionellosis_Homo sapiens_hsa051340.29659524
90Tight junction_Homo sapiens_hsa045300.29544998
91Arachidonic acid metabolism_Homo sapiens_hsa005900.28664989
92MicroRNAs in cancer_Homo sapiens_hsa052060.28226732
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.25003196
94Metabolic pathways_Homo sapiens_hsa011000.24796358
95Glucagon signaling pathway_Homo sapiens_hsa049220.24552439
96Carbon metabolism_Homo sapiens_hsa012000.23242119
97Systemic lupus erythematosus_Homo sapiens_hsa053220.23034071
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22622871
99Gap junction_Homo sapiens_hsa045400.22463242
100mTOR signaling pathway_Homo sapiens_hsa041500.22392801
101beta-Alanine metabolism_Homo sapiens_hsa004100.21937677
102Small cell lung cancer_Homo sapiens_hsa052220.21666518
103Hedgehog signaling pathway_Homo sapiens_hsa043400.19877103
104Adherens junction_Homo sapiens_hsa045200.18867824
105Choline metabolism in cancer_Homo sapiens_hsa052310.18557668
106Endocytosis_Homo sapiens_hsa041440.18427809
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18407167
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17345448
109Chemical carcinogenesis_Homo sapiens_hsa052040.17303205
110Circadian rhythm_Homo sapiens_hsa047100.15463760
111FoxO signaling pathway_Homo sapiens_hsa040680.15050700
112Mineral absorption_Homo sapiens_hsa049780.14810520
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14687054
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13608104
115HIF-1 signaling pathway_Homo sapiens_hsa040660.13034429
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12671629
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.11998383
118Fat digestion and absorption_Homo sapiens_hsa049750.11002873
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10936099
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10851013
121Fatty acid degradation_Homo sapiens_hsa000710.10212474
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.10028441
123Acute myeloid leukemia_Homo sapiens_hsa052210.09337801
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.07594934
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.06466080
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05710429
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05339599
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05035914
129Fatty acid metabolism_Homo sapiens_hsa012120.05023391
130Pathways in cancer_Homo sapiens_hsa052000.04774318
131Inositol phosphate metabolism_Homo sapiens_hsa005620.04579528
132Prostate cancer_Homo sapiens_hsa052150.04472138
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03983367
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03885567
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.03209492
136Galactose metabolism_Homo sapiens_hsa000520.02722447
137Renin-angiotensin system_Homo sapiens_hsa046140.01525511
138Basal cell carcinoma_Homo sapiens_hsa052170.01458022
139Ether lipid metabolism_Homo sapiens_hsa005650.01138146
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.00700415
141Tyrosine metabolism_Homo sapiens_hsa003500.00434735
142Parkinsons disease_Homo sapiens_hsa050120.00043543
143Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0107826
144Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0044999
145Apoptosis_Homo sapiens_hsa04210-0.0013085

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