FKBP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.67483366
2collagen fibril organization (GO:0030199)6.91370277
3keratan sulfate catabolic process (GO:0042340)5.60662076
4chondrocyte proliferation (GO:0035988)5.48119109
5bone trabecula formation (GO:0060346)5.18308504
6cell wall macromolecule catabolic process (GO:0016998)5.11372514
7cell wall macromolecule metabolic process (GO:0044036)5.11372514
8dermatan sulfate biosynthetic process (GO:0030208)5.07597236
9dermatan sulfate metabolic process (GO:0030205)4.74218984
10peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.73187085
11sequestering of extracellular ligand from receptor (GO:0035581)4.64332998
12skin morphogenesis (GO:0043589)4.63419508
13collagen metabolic process (GO:0032963)4.44419475
14collagen catabolic process (GO:0030574)4.40705847
15extracellular fibril organization (GO:0043206)4.35703451
16fibril organization (GO:0097435)4.27933087
17kidney mesenchyme development (GO:0072074)4.26854094
18fusion of sperm to egg plasma membrane (GO:0007342)4.24160000
19acrosome reaction (GO:0007340)4.18241775
20multicellular organismal macromolecule metabolic process (GO:0044259)4.14017972
21lymph vessel development (GO:0001945)4.04166762
22multicellular organismal catabolic process (GO:0044243)4.02979408
23endodermal cell differentiation (GO:0035987)4.01383745
24blood vessel maturation (GO:0001955)3.94190609
25multicellular organismal metabolic process (GO:0044236)3.92098601
26retina vasculature morphogenesis in camera-type eye (GO:0061299)3.91176912
27spermatid nucleus differentiation (GO:0007289)3.76503102
28proteasome assembly (GO:0043248)3.75086669
29chondrocyte development (GO:0002063)3.75005349
30response to pheromone (GO:0019236)3.74982760
31sperm motility (GO:0030317)3.71431407
32extracellular matrix disassembly (GO:0022617)3.71311305
33protein complex biogenesis (GO:0070271)3.71254516
34vascular endothelial growth factor signaling pathway (GO:0038084)3.69081222
35glomerular basement membrane development (GO:0032836)3.68092574
36cell migration involved in heart development (GO:0060973)3.67573450
37cellular response to vitamin D (GO:0071305)3.63292193
38metanephric mesenchyme development (GO:0072075)3.63015162
39negative regulation of chondrocyte differentiation (GO:0032331)3.59057316
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56566668
41microtubule depolymerization (GO:0007019)3.55393943
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.55392763
43NADH dehydrogenase complex assembly (GO:0010257)3.55392763
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55392763
45cellular response to vitamin (GO:0071295)3.53246308
46endothelial cell morphogenesis (GO:0001886)3.51844983
47regulation of cilium movement (GO:0003352)3.51641282
48rRNA methylation (GO:0031167)3.44425193
49protein retention in ER lumen (GO:0006621)3.40916726
50extracellular matrix assembly (GO:0085029)3.40849932
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39503651
52rRNA modification (GO:0000154)3.37668850
53protein polyglutamylation (GO:0018095)3.37560183
54mitochondrial respiratory chain complex assembly (GO:0033108)3.37151468
55extracellular matrix organization (GO:0030198)3.35523321
56peptidyl-proline hydroxylation (GO:0019511)3.35491538
57regulation of integrin-mediated signaling pathway (GO:2001044)3.34802269
58extracellular structure organization (GO:0043062)3.33989329
59mesenchymal-epithelial cell signaling (GO:0060638)3.33296742
60cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.29729836
61negative regulation of cartilage development (GO:0061037)3.26094588
62plasma membrane fusion (GO:0045026)3.25099489
63platelet dense granule organization (GO:0060155)3.19386402
64epithelial cilium movement (GO:0003351)3.18903176
65intraciliary transport (GO:0042073)3.18603458
66positive regulation of gastrulation (GO:2000543)3.18082393
67endothelial cell proliferation (GO:0001935)3.16017380
68single strand break repair (GO:0000012)3.15754140
69cullin deneddylation (GO:0010388)3.13108281
70embryonic skeletal joint morphogenesis (GO:0060272)3.12556320
71substrate-dependent cell migration (GO:0006929)3.12050899
72basement membrane organization (GO:0071711)3.11175507
73outer ear morphogenesis (GO:0042473)3.09740150
74multicellular organism reproduction (GO:0032504)3.08372881
75phagocytosis, recognition (GO:0006910)3.07181838
76axon extension involved in axon guidance (GO:0048846)3.06727596
77neuron projection extension involved in neuron projection guidance (GO:1902284)3.06727596
78pattern specification involved in kidney development (GO:0061004)3.05089752
79extracellular regulation of signal transduction (GO:1900115)3.04349515
80extracellular negative regulation of signal transduction (GO:1900116)3.04349515
81cell proliferation involved in kidney development (GO:0072111)3.04131194
82cell adhesion mediated by integrin (GO:0033627)3.03684274
83chaperone-mediated protein transport (GO:0072321)3.01369517
84positive regulation of epithelial to mesenchymal transition (GO:0010718)3.01117563
85trabecula formation (GO:0060343)3.00221870
86centriole replication (GO:0007099)2.99681960
87wound healing, spreading of epidermal cells (GO:0035313)2.99603892
88endothelium development (GO:0003158)2.99580185
89regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.97468148
90middle ear morphogenesis (GO:0042474)2.96806621
91chondroitin sulfate biosynthetic process (GO:0030206)2.96083604
92acrosome assembly (GO:0001675)2.93586238
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93552518
94smooth muscle tissue development (GO:0048745)2.92558564
95response to gravity (GO:0009629)2.90256462
96protein trimerization (GO:0070206)2.90097589
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88510728
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88510728
99positive regulation of osteoblast proliferation (GO:0033690)2.88234465
100energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86737925
101ATP synthesis coupled proton transport (GO:0015986)2.86737925
102microtubule polymerization or depolymerization (GO:0031109)2.86001666
103protein deneddylation (GO:0000338)2.85974134
104sperm-egg recognition (GO:0035036)2.85030927
105positive regulation of cartilage development (GO:0061036)2.81068628
106glycosaminoglycan catabolic process (GO:0006027)2.80234474
107cilium morphogenesis (GO:0060271)2.79934376
108negative regulation of axon guidance (GO:1902668)2.79147055
109positive regulation of blood vessel endothelial cell migration (GO:0043536)2.78226913
110positive regulation of extracellular matrix organization (GO:1903055)2.77325032
111glomerular filtration (GO:0003094)2.76134738
112nonmotile primary cilium assembly (GO:0035058)2.75908771
113cellular response to BMP stimulus (GO:0071773)2.75872349
114response to BMP (GO:0071772)2.75872349
115regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.74830502
116cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.73105350
117chondroitin sulfate catabolic process (GO:0030207)2.73046018
118cell proliferation involved in metanephros development (GO:0072203)2.72924968
119negative regulation of biomineral tissue development (GO:0070168)2.72731254
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.72698321
121ossification (GO:0001503)2.71526154
122craniofacial suture morphogenesis (GO:0097094)2.70253097
123aminoglycan catabolic process (GO:0006026)2.69639908
124regulation of extracellular matrix disassembly (GO:0010715)2.69164543
125head development (GO:0060322)2.68343317
126definitive hemopoiesis (GO:0060216)2.66722688
127protein hydroxylation (GO:0018126)2.66161441
128regulation of SMAD protein import into nucleus (GO:0060390)2.65831194
129positive regulation of endothelial cell apoptotic process (GO:2000353)2.61397965
130response to redox state (GO:0051775)2.60919232
131binding of sperm to zona pellucida (GO:0007339)2.60686418
132protein targeting to Golgi (GO:0000042)2.60655224
133mesenchyme morphogenesis (GO:0072132)2.60142405
134establishment of protein localization to Golgi (GO:0072600)2.59758290
135protein localization to cell surface (GO:0034394)2.59605621
136negative regulation of axon extension involved in axon guidance (GO:0048843)2.59433390
137embryonic cranial skeleton morphogenesis (GO:0048701)2.58689585
138glomerulus development (GO:0032835)2.58322611
139pathway-restricted SMAD protein phosphorylation (GO:0060389)2.56592705
140G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.56424731
141regulation of cartilage development (GO:0061035)2.55675462
142positive regulation of macrophage activation (GO:0043032)2.55668133
143sequestering of actin monomers (GO:0042989)2.52389490
144retinal ganglion cell axon guidance (GO:0031290)2.51893357
145spermatid development (GO:0007286)2.48258924
146microtubule severing (GO:0051013)2.46586795
147protein neddylation (GO:0045116)2.46005483
148regulation of cardioblast proliferation (GO:0003264)2.44572438
149regulation of secondary heart field cardioblast proliferation (GO:0003266)2.44572438
150seminiferous tubule development (GO:0072520)2.43643989
151positive regulation of endothelial cell differentiation (GO:0045603)2.41152696
152cilium organization (GO:0044782)2.40753322
153water-soluble vitamin biosynthetic process (GO:0042364)2.39772532
154cranial nerve morphogenesis (GO:0021602)2.39340505
155mannosylation (GO:0097502)2.39136083
156cilium assembly (GO:0042384)2.37854420
157protein localization to Golgi apparatus (GO:0034067)2.36783834
158epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.36407091
159axonemal dynein complex assembly (GO:0070286)2.35236517
160cilium movement (GO:0003341)2.35140572
161negative chemotaxis (GO:0050919)2.33799330
162regulation of organ formation (GO:0003156)2.31971156
163respiratory electron transport chain (GO:0022904)2.26782120
164retrograde transport, vesicle recycling within Golgi (GO:0000301)2.26019768
165smoothened signaling pathway (GO:0007224)2.26017465
166mesenchymal cell differentiation involved in kidney development (GO:0072161)2.25687651
167mesenchymal cell differentiation involved in renal system development (GO:2001012)2.25687651
168cellular ketone body metabolic process (GO:0046950)2.24324123
169electron transport chain (GO:0022900)2.22714739
170protein-cofactor linkage (GO:0018065)2.22575839
171resolution of meiotic recombination intermediates (GO:0000712)2.22131238
172ganglion development (GO:0061548)2.21128368
173artery development (GO:0060840)2.19889140
174single fertilization (GO:0007338)2.18709586
175spermatogenesis (GO:0007283)2.16933626
176establishment of planar polarity (GO:0001736)2.16788895
177establishment of tissue polarity (GO:0007164)2.16788895
178male gamete generation (GO:0048232)2.16349168
179calcium ion-dependent exocytosis (GO:0017156)2.15718345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.13137016
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.19344006
3CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse3.93429940
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.70028424
5WT1_19549856_ChIP-ChIP_CCG9911_Human3.65264532
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.56688571
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.49388253
8CJUN_26792858_Chip-Seq_BT549_Human3.17962896
9CLOCK_20551151_ChIP-Seq_293T_Human2.96826944
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.82553397
11CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.80573894
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.70542615
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.69262196
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.63279127
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.61298580
16NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.53711922
17NRF2_20460467_ChIP-Seq_MEFs_Mouse2.53711922
18BRD4_25478319_ChIP-Seq_HGPS_Human2.49298845
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42916617
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.33992603
21GBX2_23144817_ChIP-Seq_PC3_Human2.33359554
22VDR_22108803_ChIP-Seq_LS180_Human2.26407294
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21454350
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.20565702
25P300_19829295_ChIP-Seq_ESCs_Human2.19594125
26TAF15_26573619_Chip-Seq_HEK293_Human2.19118811
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.16474837
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15131739
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09361858
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06158662
31TP53_18474530_ChIP-ChIP_U2OS_Human1.95611227
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92629802
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.90594245
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89599756
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88363864
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87058425
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79231797
38IGF1R_20145208_ChIP-Seq_DFB_Human1.76797515
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75392204
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.69562023
41* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69405063
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67042946
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61595674
44CBP_20019798_ChIP-Seq_JUKART_Human1.61110551
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61110551
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57712838
47MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.56801889
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.54794981
49NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.54477385
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54362814
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52698771
52JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52419073
53SMAD4_21799915_ChIP-Seq_A2780_Human1.52184555
54SA1_22415368_ChIP-Seq_MEFs_Mouse1.50846996
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49894027
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48703144
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46975288
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.46366908
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.44498596
60* SOX2_20726797_ChIP-Seq_SW620_Human1.44271896
61AR_25329375_ChIP-Seq_VCAP_Human1.43914577
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43349672
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42576651
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42576651
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.41914518
66* NFI_21473784_ChIP-Seq_ESCs_Mouse1.41623840
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39628848
68PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.39526418
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37978044
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37431558
71JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37155389
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36298054
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35655865
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34582454
75ELK1_19687146_ChIP-ChIP_HELA_Human1.33455646
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32975213
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32079091
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.31964082
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29455897
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25457835
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24214249
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23995992
83PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22648038
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22475441
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22053886
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.21670210
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21518110
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.21333324
89STAT3_23295773_ChIP-Seq_U87_Human1.20285954
90NANOG_19829295_ChIP-Seq_ESCs_Human1.19753671
91SOX2_19829295_ChIP-Seq_ESCs_Human1.19753671
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.19528913
93CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19043540
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.18948776
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17495016
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16732361
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16379602
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16362761
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16120145
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.16068748
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15218728
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.14372642
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.13448275
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12439755
105JUN_21703547_ChIP-Seq_K562_Human1.12257968
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12176618
107RUNX2_22187159_ChIP-Seq_PCA_Human1.11852563
108TCF4_22108803_ChIP-Seq_LS180_Human1.10767101
109FUS_26573619_Chip-Seq_HEK293_Human1.10715723
110RNF2_27304074_Chip-Seq_NSC_Mouse1.10698558
111NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10263441
112JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08346721
113* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06794231
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06376061
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06144716
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05420504
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05420504
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05156223
119MYC_18940864_ChIP-ChIP_HL60_Human1.04181817
120TBX20_22080862_ChIP-Seq_HEART_Mouse1.03708538
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.03708538
122P53_22387025_ChIP-Seq_ESCs_Mouse1.03492743
123* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03313000
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02613624
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02534919
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02486817
127ESR1_20079471_ChIP-ChIP_T-47D_Human1.02176601
128TP53_22573176_ChIP-Seq_HFKS_Human1.01868095
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.01503298
130IRF1_19129219_ChIP-ChIP_H3396_Human1.01500290
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99481841
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98852909
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98555880
134TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98485664
135TCF4_23295773_ChIP-Seq_U87_Human0.98352691
136ZNF274_21170338_ChIP-Seq_K562_Hela0.97728701
137SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97546713
138ELK1_22589737_ChIP-Seq_MCF10A_Human0.97419116
139AR_21572438_ChIP-Seq_LNCaP_Human0.95497702
140EWS_26573619_Chip-Seq_HEK293_Human0.94669504
141BCAT_22108803_ChIP-Seq_LS180_Human0.94187904
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.93302626
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91720427
144KDM2B_26808549_Chip-Seq_REH_Human0.91077407
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90682941
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90161586
147CRX_20693478_ChIP-Seq_RETINA_Mouse0.88832902
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88648557
149GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87953003
150SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87031497
151ER_23166858_ChIP-Seq_MCF-7_Human0.86757886
152PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86584401
153GF1B_26923725_Chip-Seq_HPCs_Mouse0.86297478
154TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86245410
155ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85569826
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85432460
157SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83222312
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.83096700
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81864621
160TCF4_18268006_ChIP-ChIP_LS174T_Human0.81510681
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.81411947
162UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81247114
163VDR_24787735_ChIP-Seq_THP-1_Human0.80320445
164OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79902610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.73724599
2MP0005503_abnormal_tendon_morphology6.96052773
3MP0005275_abnormal_skin_tensile5.44652088
4MP0003279_aneurysm3.78420153
5MP0006054_spinal_hemorrhage3.33839370
6MP0004272_abnormal_basement_membrane2.92782493
7MP0001542_abnormal_bone_strength2.82354128
8MP0001958_emphysema2.79792039
9MP0009384_cardiac_valve_regurgitation2.50671724
10MP0002102_abnormal_ear_morphology2.43705000
11MP0005508_abnormal_skeleton_morphology2.41335169
12MP0003705_abnormal_hypodermis_morpholog2.39759042
13MP0001879_abnormal_lymphatic_vessel2.27635363
14MP0010368_abnormal_lymphatic_system2.26784369
15MP0009250_abnormal_appendicular_skeleto2.11077684
16MP0002108_abnormal_muscle_morphology2.08922139
17MP0002060_abnormal_skin_morphology2.03305626
18MP0005257_abnormal_intraocular_pressure1.87252335
19MP0005623_abnormal_meninges_morphology1.87006612
20MP0002234_abnormal_pharynx_morphology1.84685270
21MP0002295_abnormal_pulmonary_circulatio1.84508837
22MP0000372_irregular_coat_pigmentation1.79080820
23MP0009379_abnormal_foot_pigmentation1.73974827
24MP0002896_abnormal_bone_mineralization1.71820887
25MP0003385_abnormal_body_wall1.63652825
26MP0002282_abnormal_trachea_morphology1.58145383
27MP0005390_skeleton_phenotype1.57945543
28MP0002933_joint_inflammation1.57486150
29MP0006072_abnormal_retinal_apoptosis1.56429800
30MP0005253_abnormal_eye_physiology1.46602028
31MP0001529_abnormal_vocalization1.46256230
32MP0008789_abnormal_olfactory_epithelium1.45681812
33MP0002837_dystrophic_cardiac_calcinosis1.45637751
34MP0004134_abnormal_chest_morphology1.43699711
35MP0005670_abnormal_white_adipose1.43259924
36MP0002115_abnormal_skeleton_extremities1.41459932
37MP0000767_abnormal_smooth_muscle1.41318913
38MP0000163_abnormal_cartilage_morphology1.36956852
39MP0005023_abnormal_wound_healing1.34285919
40MP0002751_abnormal_autonomic_nervous1.33518805
41MP0002233_abnormal_nose_morphology1.32776956
42MP0003942_abnormal_urinary_system1.31242195
43MP0003724_increased_susceptibility_to1.30633111
44MP0000013_abnormal_adipose_tissue1.29996687
45MP0003283_abnormal_digestive_organ1.29522438
46MP0005408_hypopigmentation1.29297308
47MP0003880_abnormal_central_pattern1.28435329
48MP0005551_abnormal_eye_electrophysiolog1.27693046
49MP0000569_abnormal_digit_pigmentation1.18999902
50MP0002113_abnormal_skeleton_development1.18877534
51MP0002998_abnormal_bone_remodeling1.18016041
52MP0001243_abnormal_dermal_layer1.17441809
53MP0000343_altered_response_to1.16559427
54MP0001533_abnormal_skeleton_physiology1.15753783
55MP0005171_absent_coat_pigmentation1.14069341
56MP0008775_abnormal_heart_ventricle1.13678361
57MP0006292_abnormal_olfactory_placode1.13119370
58MP0005187_abnormal_penis_morphology1.09025095
59MP0006276_abnormal_autonomic_nervous1.07622958
60MP0001293_anophthalmia1.06077286
61MP0003136_yellow_coat_color1.05147798
62MP0003566_abnormal_cell_adhesion1.04543764
63MP0003698_abnormal_male_reproductive1.04521968
64MP0003795_abnormal_bone_structure1.01403057
65MP0003186_abnormal_redox_activity0.98952136
66MP0003828_pulmonary_edema0.98311402
67MP0009697_abnormal_copulation0.97208350
68MP0010386_abnormal_urinary_bladder0.96638714
69MP0000751_myopathy0.96613225
70MP0002932_abnormal_joint_morphology0.96092754
71MP0005391_vision/eye_phenotype0.95918931
72MP0000733_abnormal_muscle_development0.95476177
73MP0002877_abnormal_melanocyte_morpholog0.95470147
74MP0002109_abnormal_limb_morphology0.95166661
75MP0010030_abnormal_orbit_morphology0.95036630
76MP0003011_delayed_dark_adaptation0.93441637
77MP0004133_heterotaxia0.93346738
78MP0000049_abnormal_middle_ear0.92896283
79MP0001929_abnormal_gametogenesis0.90385435
80MP0000026_abnormal_inner_ear0.90210921
81MP0002128_abnormal_blood_circulation0.90150656
82MP0003122_maternal_imprinting0.89984310
83MP0002090_abnormal_vision0.88548556
84MP0001286_abnormal_eye_development0.88225570
85MP0001299_abnormal_eye_distance/0.88130122
86MP0002938_white_spotting0.87488508
87MP0009780_abnormal_chondrocyte_physiolo0.87405168
88MP0002127_abnormal_cardiovascular_syste0.87180581
89MP0004233_abnormal_muscle_weight0.86991077
90MP0004084_abnormal_cardiac_muscle0.86877330
91MP0002133_abnormal_respiratory_system0.86484058
92MP0005388_respiratory_system_phenotype0.86484058
93MP0008058_abnormal_DNA_repair0.85313941
94MP0001984_abnormal_olfaction0.84626255
95MP0003718_maternal_effect0.84426726
96MP0005164_abnormal_response_to0.82679683
97MP0000538_abnormal_urinary_bladder0.82534593
98MP0005084_abnormal_gallbladder_morpholo0.81720007
99MP0005595_abnormal_vascular_smooth0.81407956
100MP0004085_abnormal_heartbeat0.81133345
101MP0000534_abnormal_ureter_morphology0.81036091
102MP0003119_abnormal_digestive_system0.80206684
103MP0003115_abnormal_respiratory_system0.78272620
104MP0003941_abnormal_skin_development0.77206279
105MP0002249_abnormal_larynx_morphology0.77111703
106MP0003091_abnormal_cell_migration0.77018803
107MP0003878_abnormal_ear_physiology0.76690218
108MP0005377_hearing/vestibular/ear_phenot0.76690218
109MP0001614_abnormal_blood_vessel0.74761918
110MP0009053_abnormal_anal_canal0.74658189
111MP0002736_abnormal_nociception_after0.73763045
112MP0005195_abnormal_posterior_eye0.73601895
113MP0001175_abnormal_lung_morphology0.73567923
114MP0000432_abnormal_head_morphology0.73261413
115MP0002177_abnormal_outer_ear0.72813422
116MP0000778_abnormal_nervous_system0.72500283
117MP0004215_abnormal_myocardial_fiber0.71401803
118MP0000750_abnormal_muscle_regeneration0.70892837
119MP0003567_abnormal_fetal_cardiomyocyte0.70265690
120MP0005369_muscle_phenotype0.70176741
121MP0002160_abnormal_reproductive_system0.69797901
122MP0000749_muscle_degeneration0.69596620
123MP0002752_abnormal_somatic_nervous0.69243173
124MP0002697_abnormal_eye_size0.68966104
125MP0008995_early_reproductive_senescence0.68888718
126MP0001270_distended_abdomen0.68405072
127MP0004883_abnormal_blood_vessel0.68022697
128MP0006138_congestive_heart_failure0.67311953
129MP0000762_abnormal_tongue_morphology0.66230639
130MP0000003_abnormal_adipose_tissue0.66168401
131MP0003755_abnormal_palate_morphology0.66115736
132MP0000428_abnormal_craniofacial_morphol0.65848504
133MP0003950_abnormal_plasma_membrane0.65136002
134MP0002116_abnormal_craniofacial_bone0.64460513
135MP0004484_altered_response_of0.62907082
136MP0004185_abnormal_adipocyte_glucose0.61527838
137MP0000516_abnormal_urinary_system0.61094723
138MP0005367_renal/urinary_system_phenotyp0.61094723
139MP0002009_preneoplasia0.61043003
140MP0003935_abnormal_craniofacial_develop0.60810829
141MP0004808_abnormal_hematopoietic_stem0.60054484
142MP0002089_abnormal_postnatal_growth/wei0.59584174
143MP0000249_abnormal_blood_vessel0.59392981
144MP0005197_abnormal_uvea_morphology0.57936784
145MP0001915_intracranial_hemorrhage0.57488085
146MP0005220_abnormal_exocrine_pancreas0.57398794
147MP0002114_abnormal_axial_skeleton0.57345911
148MP0005410_abnormal_fertilization0.56509654
149MP0001177_atelectasis0.56404500
150MP0005385_cardiovascular_system_phenoty0.56102902
151MP0001544_abnormal_cardiovascular_syste0.56102902
152MP0003937_abnormal_limbs/digits/tail_de0.55946456
153MP0000759_abnormal_skeletal_muscle0.54310072

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.04886023
2Premature rupture of membranes (HP:0001788)7.52589228
3Aortic dissection (HP:0002647)4.93410704
4Abnormality of dentin (HP:0010299)4.91484179
5Soft skin (HP:0000977)4.88189120
6Ankle contracture (HP:0006466)4.61546225
7Biconcave vertebral bodies (HP:0004586)4.55177258
8Neonatal short-limb short stature (HP:0008921)4.25094524
9Wormian bones (HP:0002645)4.18471070
10Aortic aneurysm (HP:0004942)4.16948552
11Broad metatarsal (HP:0001783)4.14408863
12Vertebral compression fractures (HP:0002953)4.12476708
13Atrophic scars (HP:0001075)4.12212938
14Cervical subluxation (HP:0003308)4.11884514
15Follicular hyperkeratosis (HP:0007502)3.65822544
16Blue sclerae (HP:0000592)3.54913175
17Bladder diverticulum (HP:0000015)3.50964942
18Shallow orbits (HP:0000586)3.39241226
19Peritonitis (HP:0002586)3.34072098
20Spinal rigidity (HP:0003306)3.24161010
21Dilatation of the ascending aorta (HP:0005111)3.24078863
22Fragile skin (HP:0001030)3.14962977
23Vascular tortuosity (HP:0004948)3.13673329
24Cerebral aneurysm (HP:0004944)3.12914361
25Type 1 muscle fiber predominance (HP:0003803)3.08911803
26Nephronophthisis (HP:0000090)3.06028414
27Pancreatic fibrosis (HP:0100732)2.99701421
28Acute necrotizing encephalopathy (HP:0006965)2.99342809
29True hermaphroditism (HP:0010459)2.96658270
30Renal Fanconi syndrome (HP:0001994)2.96464119
31Spondylolisthesis (HP:0003302)2.92623356
32Mitral valve prolapse (HP:0001634)2.92136905
33Nonimmune hydrops fetalis (HP:0001790)2.91119920
34Abnormality of the acetabulum (HP:0003170)2.85615800
35Genu recurvatum (HP:0002816)2.84531890
36Chronic hepatic failure (HP:0100626)2.84031457
37Pancreatic cysts (HP:0001737)2.83356570
38Abnormal delivery (HP:0001787)2.83124968
39Increased corneal curvature (HP:0100692)2.82649084
40Keratoconus (HP:0000563)2.82649084
41Medial flaring of the eyebrow (HP:0010747)2.80939334
42Molar tooth sign on MRI (HP:0002419)2.74694922
43Abnormality of midbrain morphology (HP:0002418)2.74694922
44Wrist flexion contracture (HP:0001239)2.72020055
45Acute encephalopathy (HP:0006846)2.62329492
46Mitochondrial inheritance (HP:0001427)2.59867329
47Progressive macrocephaly (HP:0004481)2.59012774
48Arterial tortuosity (HP:0005116)2.55345697
49Osteoarthritis (HP:0002758)2.54763428
50Increased hepatocellular lipid droplets (HP:0006565)2.53859845
51Joint laxity (HP:0001388)2.52949313
52Congenital primary aphakia (HP:0007707)2.52786200
53Abnormality of the renal medulla (HP:0100957)2.52737835
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.50472584
55Bell-shaped thorax (HP:0001591)2.50299462
56Intestinal atresia (HP:0011100)2.48394148
57Wide anterior fontanel (HP:0000260)2.48047720
58Cupped ribs (HP:0000887)2.47031925
59Decreased skull ossification (HP:0004331)2.46776771
60Abnormal mitochondria in muscle tissue (HP:0008316)2.46362557
61Hyperextensible skin (HP:0000974)2.45816209
62Increased CSF lactate (HP:0002490)2.42038750
63Occipital encephalocele (HP:0002085)2.42025189
64Coxa vara (HP:0002812)2.41697456
65Gait imbalance (HP:0002141)2.41683616
66Beaking of vertebral bodies (HP:0004568)2.41489100
67Congenital, generalized hypertrichosis (HP:0004540)2.40009905
68Platyspondyly (HP:0000926)2.39946085
69Epiphyseal dysplasia (HP:0002656)2.39895104
70Mild short stature (HP:0003502)2.38793942
71Metaphyseal dysplasia (HP:0100255)2.38690506
72Slender build (HP:0001533)2.38669331
73Hepatocellular necrosis (HP:0001404)2.35325727
74Abnormality of the phalanges of the 2nd finger (HP:0009541)2.32135786
75Overgrowth (HP:0001548)2.32110550
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.31281852
77Osteolytic defects of the hand bones (HP:0009699)2.31281852
78Breech presentation (HP:0001623)2.30808525
79Femoral bowing (HP:0002980)2.30226797
80Absent frontal sinuses (HP:0002688)2.30059808
81Mitral regurgitation (HP:0001653)2.29836509
82Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.28831178
83Delayed gross motor development (HP:0002194)2.26951414
84Hepatic necrosis (HP:0002605)2.26644014
85Aortic regurgitation (HP:0001659)2.26590460
86Nephrogenic diabetes insipidus (HP:0009806)2.26337073
87Increased connective tissue (HP:0009025)2.25002663
88Abnormality of skull ossification (HP:0002703)2.24253803
89Methylmalonic acidemia (HP:0002912)2.22840516
90Mesomelia (HP:0003027)2.19991283
91Delayed closure of the anterior fontanelle (HP:0001476)2.19390265
92Tubulointerstitial nephritis (HP:0001970)2.19117255
93Genital tract atresia (HP:0001827)2.18854719
94Generalized aminoaciduria (HP:0002909)2.18795535
95Spinal cord lesions (HP:0100561)2.16610592
96Syringomyelia (HP:0003396)2.16610592
97Infantile muscular hypotonia (HP:0008947)2.15053858
98Venous insufficiency (HP:0005293)2.14505626
99Tibial bowing (HP:0002982)2.14387135
100Lipid accumulation in hepatocytes (HP:0006561)2.14045514
101Vaginal atresia (HP:0000148)2.10675780
102Delayed cranial suture closure (HP:0000270)2.10114749
103Broad ribs (HP:0000885)2.09015646
104Hypothermia (HP:0002045)2.08504349
105Sclerocornea (HP:0000647)2.07593032
106Postaxial foot polydactyly (HP:0001830)2.07294734
107Venous abnormality (HP:0002624)2.06813240
108Morphological abnormality of the middle ear (HP:0008609)2.03068012
109Elbow flexion contracture (HP:0002987)2.02045988
110Joint stiffness (HP:0001387)2.00358640
111Attenuation of retinal blood vessels (HP:0007843)2.00092196
112Short tibia (HP:0005736)2.00035643
113Flared iliac wings (HP:0002869)1.99837453
114Increased variability in muscle fiber diameter (HP:0003557)1.99615202
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.99538962
116Short nail (HP:0001799)1.99409199
117Abnormality of renal resorption (HP:0011038)1.98548725
118Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.98216419
119Calcaneovalgus deformity (HP:0001848)1.98137476
1203-Methylglutaconic aciduria (HP:0003535)1.97441932
121Mildly elevated creatine phosphokinase (HP:0008180)1.97284399
122Ectopia lentis (HP:0001083)1.97273948
123Bowel diverticulosis (HP:0005222)1.97264947
124Bifid tongue (HP:0010297)1.96909176
125Pulmonary artery stenosis (HP:0004415)1.96424843
126Glycosuria (HP:0003076)1.92356739
127Abnormality of urine glucose concentration (HP:0011016)1.92356739
128Abnormality of macular pigmentation (HP:0008002)1.91937376
129Osteopenia (HP:0000938)1.89712375
130Type I transferrin isoform profile (HP:0003642)1.89008390
131Aortic valve stenosis (HP:0001650)1.88695640
132Thin bony cortex (HP:0002753)1.87781141
133Postaxial hand polydactyly (HP:0001162)1.87414715
134Hypoplastic ischia (HP:0003175)1.86614417
135Deformed tarsal bones (HP:0008119)1.84431272
136Broad long bones (HP:0005622)1.83891886
137Anencephaly (HP:0002323)1.83071637
138Abnormality of the frontal sinuses (HP:0002687)1.80945213
139Camptodactyly of toe (HP:0001836)1.80482367
140Anophthalmia (HP:0000528)1.80383219
141Inguinal hernia (HP:0000023)1.78168101
142Abnormality of the ischium (HP:0003174)1.77463457
143Exertional dyspnea (HP:0002875)1.77301274
144Abnormality of skeletal muscle fiber size (HP:0012084)1.77111325
145Methylmalonic aciduria (HP:0012120)1.77088425
146Hyperglycinemia (HP:0002154)1.76919047
147Amniotic constriction ring (HP:0009775)1.76539632
148Abnormality of placental membranes (HP:0011409)1.76539632
149Adrenal hypoplasia (HP:0000835)1.75648498
150Aplasia/Hypoplasia of the lens (HP:0008063)1.75481809
151Hip contracture (HP:0003273)1.75399056
152Disproportionate short-trunk short stature (HP:0003521)1.74014633
153Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.73314400
154Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.71603693
155Persistence of primary teeth (HP:0006335)1.70935218
156Renal hypoplasia (HP:0000089)1.70609558
157Knee flexion contracture (HP:0006380)1.70182095
158Patchy hypopigmentation of hair (HP:0011365)1.69972091
159Cystic liver disease (HP:0006706)1.69941733
160Generalized amyotrophy (HP:0003700)1.69289640
161Aneurysm (HP:0002617)1.68251526
162Cerebral edema (HP:0002181)1.68040816
163Short hallux (HP:0010109)1.67804302
164Abnormality of the renal cortex (HP:0011035)1.67397255
165Delayed CNS myelination (HP:0002188)1.67367084
166Round ear (HP:0100830)1.67209710
167Tubulointerstitial abnormality (HP:0001969)1.66612950
168Stage 5 chronic kidney disease (HP:0003774)1.65888482
169Limited hip movement (HP:0008800)1.65155032
170Abnormality of the peritoneum (HP:0002585)1.64963410
171Broad foot (HP:0001769)1.64206892
172Supernumerary spleens (HP:0009799)1.63254235
173Type II lissencephaly (HP:0007260)1.61187652
174Abnormal respiratory epithelium morphology (HP:0012253)1.60678626
175Abnormal respiratory motile cilium morphology (HP:0005938)1.60678626
176Poor coordination (HP:0002370)1.56937877
177Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.56594772
178Abnormal protein N-linked glycosylation (HP:0012347)1.56594772
179Abnormal protein glycosylation (HP:0012346)1.56594772
180Abnormal glycosylation (HP:0012345)1.56594772
181Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56396246
182Hyperalaninemia (HP:0003348)1.56396246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.69052342
2MAP4K24.08879349
3TGFBR23.29049529
4PLK43.18894476
5INSRR3.04111545
6PDK32.84262483
7PDK42.84262483
8MYLK2.83439338
9NME22.64979380
10ERBB32.61263736
11TIE12.59421768
12PIK3CG2.48656120
13FRK2.46671450
14VRK22.41746944
15PDGFRA2.31449408
16ZAK2.24873110
17TTN2.24473797
18PDK22.22852207
19WNK32.13956234
20KDR2.00873571
21MAP3K122.00390993
22PIK3CA1.99470064
23EPHB21.98589696
24TGFBR11.93273352
25TESK11.84381555
26TRIB31.78096891
27MAP3K41.68467728
28FER1.60482182
29STK161.59548077
30LIMK11.57450104
31TRPM71.53134718
32LATS11.52894760
33KIT1.50840349
34EPHA31.50463620
35PIM21.50162239
36ERN11.48823825
37PTK2B1.45704993
38FLT31.43701029
39PAK21.41602627
40ADRBK21.40819282
41ILK1.40549666
42DYRK31.35683663
43MARK11.34767542
44BCR1.31469989
45SRPK11.25225542
46BCKDK1.24948440
47MAP2K71.23397367
48CDK81.22468479
49AKT31.22163818
50PNCK1.18926010
51NEK91.18838858
52GRK11.17831227
53STK31.16740379
54BMPR1B1.15594544
55PAK31.14731838
56TRIM281.13734854
57LATS21.13282345
58TEC1.12097526
59RPS6KA41.11616685
60CASK1.10102146
61EIF2AK31.09750975
62DYRK21.09680340
63PLK21.06320953
64TNIK0.99276827
65NEK10.98992196
66CCNB10.96475790
67MAP3K30.93149592
68PRKD30.91534956
69EPHA40.90724179
70CSNK1G10.90565510
71IRAK10.88847086
72STK38L0.88073120
73ROCK10.87805467
74CSNK1G30.87450957
75MKNK10.86149949
76PAK40.86024373
77CSNK1G20.82910556
78NUAK10.82184859
79MAPK130.80054603
80BRD40.79649901
81LRRK20.79340439
82CAMKK20.78546684
83STK240.78428470
84MAPK150.78205943
85PKN20.75762124
86PTK60.73504478
87DMPK0.73026694
88CSNK1A1L0.72008992
89PRKG20.70836449
90IRAK40.70059633
91MST40.69364630
92PINK10.67507652
93PDGFRB0.66570758
94FGFR20.64896530
95BUB10.64477448
96GRK50.60091017
97CAMK1D0.59705897
98PLK10.58411266
99ACVR1B0.58294918
100NLK0.58190062
101PRKCG0.57399638
102OBSCN0.57351209
103TAF10.56969291
104STK390.56558500
105WNK40.55807495
106IGF1R0.54877064
107BRSK20.54734180
108EIF2AK10.54536898
109WEE10.53595253
110NME10.52188659
111CLK10.50379727
112PRKG10.50058675
113ERBB40.49979517
114PRKD20.47175217
115MOS0.46549878
116MET0.46373820
117JAK30.44392899
118MAPKAPK50.44166407
119ADRBK10.43290097
120CAMK2A0.42907591
121MAPK120.42815086
122MINK10.42723094
123MAPK70.41214522
124INSR0.41025561
125CDK60.40475357
126CSNK1A10.37487211
127PRKCE0.37356541
128MAPKAPK30.36217971
129MAP2K30.34891799
130CDK190.34516416
131CSNK2A10.34360538
132EIF2AK20.34150982
133MUSK0.33776790
134DAPK30.33472927
135PRKACB0.33070986
136ABL20.32975771
137ATM0.32756473
138RPS6KA60.32308435
139PLK30.32181436
140PRKACA0.31985741
141FGFR10.31409925
142BMPR20.31360129
143PBK0.31164273
144VRK10.30904994
145YES10.30886205
146FGFR30.30750390
147DYRK1B0.30260445
148PRKCH0.29986051
149AURKB0.29750549
150ROCK20.29670734
151GRK70.27828961
152JAK10.27758840
153PRKD10.27187894
154IKBKB0.27067439
155MAPK40.26545528
156SIK10.26089541
157MKNK20.25894301

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.85222609
2Protein export_Homo sapiens_hsa030603.63232805
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.42111445
4Protein digestion and absorption_Homo sapiens_hsa049742.97927859
5Focal adhesion_Homo sapiens_hsa045102.92077347
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86856213
7Malaria_Homo sapiens_hsa051442.75524168
8TGF-beta signaling pathway_Homo sapiens_hsa043502.39936630
9Ribosome_Homo sapiens_hsa030102.20285622
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.05365069
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02358431
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.94033217
13PI3K-Akt signaling pathway_Homo sapiens_hsa041511.89203636
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.87694938
15N-Glycan biosynthesis_Homo sapiens_hsa005101.81265589
16Propanoate metabolism_Homo sapiens_hsa006401.80294446
17Dilated cardiomyopathy_Homo sapiens_hsa054141.76594466
18Homologous recombination_Homo sapiens_hsa034401.73775845
19Phototransduction_Homo sapiens_hsa047441.73124824
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.72745154
21Proteoglycans in cancer_Homo sapiens_hsa052051.72739232
22Amoebiasis_Homo sapiens_hsa051461.65125600
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60973322
24Small cell lung cancer_Homo sapiens_hsa052221.56160117
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52038221
26One carbon pool by folate_Homo sapiens_hsa006701.48790952
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44914135
28Fanconi anemia pathway_Homo sapiens_hsa034601.44776046
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44487453
30Arachidonic acid metabolism_Homo sapiens_hsa005901.44089560
31Adherens junction_Homo sapiens_hsa045201.41993339
32Nucleotide excision repair_Homo sapiens_hsa034201.41853442
33Non-homologous end-joining_Homo sapiens_hsa034501.37542618
34Butanoate metabolism_Homo sapiens_hsa006501.37449772
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.37149780
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35756017
37RNA degradation_Homo sapiens_hsa030181.28826455
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.28542624
39RNA transport_Homo sapiens_hsa030131.24973192
40Mismatch repair_Homo sapiens_hsa034301.16226986
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16082018
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15285188
43Basal cell carcinoma_Homo sapiens_hsa052171.12033835
44Hippo signaling pathway_Homo sapiens_hsa043901.11976826
45Olfactory transduction_Homo sapiens_hsa047401.11181211
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11012101
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09923491
48Selenocompound metabolism_Homo sapiens_hsa004501.08358010
49Renin-angiotensin system_Homo sapiens_hsa046141.07764237
50Glutathione metabolism_Homo sapiens_hsa004801.07000257
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06153581
52Fatty acid elongation_Homo sapiens_hsa000621.04635065
53Platelet activation_Homo sapiens_hsa046111.03891967
54Other glycan degradation_Homo sapiens_hsa005111.03816928
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03331796
56Pyrimidine metabolism_Homo sapiens_hsa002401.00711223
57Toxoplasmosis_Homo sapiens_hsa051450.99789759
58Hedgehog signaling pathway_Homo sapiens_hsa043400.98601412
59Prostate cancer_Homo sapiens_hsa052150.96559163
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96176493
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95901452
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.95713858
63Thyroid hormone synthesis_Homo sapiens_hsa049180.95665418
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95299546
65Pathways in cancer_Homo sapiens_hsa052000.94798455
66Folate biosynthesis_Homo sapiens_hsa007900.93701484
67Peroxisome_Homo sapiens_hsa041460.92797281
68Chemical carcinogenesis_Homo sapiens_hsa052040.92522653
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92154815
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92150404
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89797257
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89631679
73TNF signaling pathway_Homo sapiens_hsa046680.89320397
74Viral myocarditis_Homo sapiens_hsa054160.88817562
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.88266435
76Bladder cancer_Homo sapiens_hsa052190.88085306
77MicroRNAs in cancer_Homo sapiens_hsa052060.86823051
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86466690
79Metabolic pathways_Homo sapiens_hsa011000.84252334
80Phagosome_Homo sapiens_hsa041450.83836169
81Huntingtons disease_Homo sapiens_hsa050160.82912213
82HTLV-I infection_Homo sapiens_hsa051660.82644604
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82239645
84Regulation of autophagy_Homo sapiens_hsa041400.81594471
85Melanoma_Homo sapiens_hsa052180.80107810
86Spliceosome_Homo sapiens_hsa030400.77940684
87p53 signaling pathway_Homo sapiens_hsa041150.77724399
88Pyruvate metabolism_Homo sapiens_hsa006200.77552785
89Retinol metabolism_Homo sapiens_hsa008300.76787213
90Fatty acid degradation_Homo sapiens_hsa000710.76550417
91Complement and coagulation cascades_Homo sapiens_hsa046100.76064071
92Base excision repair_Homo sapiens_hsa034100.75484059
93Shigellosis_Homo sapiens_hsa051310.73642739
94Fatty acid biosynthesis_Homo sapiens_hsa000610.73516308
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73470765
96Tryptophan metabolism_Homo sapiens_hsa003800.73034327
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71283274
98HIF-1 signaling pathway_Homo sapiens_hsa040660.67768644
99Parkinsons disease_Homo sapiens_hsa050120.65397033
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65295927
101Legionellosis_Homo sapiens_hsa051340.65182647
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65171084
103Pertussis_Homo sapiens_hsa051330.64820710
104Wnt signaling pathway_Homo sapiens_hsa043100.64467349
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64313067
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63987466
107Steroid biosynthesis_Homo sapiens_hsa001000.63409364
108Sulfur relay system_Homo sapiens_hsa041220.62912715
109Collecting duct acid secretion_Homo sapiens_hsa049660.62893135
110Taste transduction_Homo sapiens_hsa047420.62108330
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61650805
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.59920901
113Rap1 signaling pathway_Homo sapiens_hsa040150.59550096
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58780254
115Chronic myeloid leukemia_Homo sapiens_hsa052200.58773582
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.57640848
117Fatty acid metabolism_Homo sapiens_hsa012120.57636210
118Nicotine addiction_Homo sapiens_hsa050330.57225202
119Leishmaniasis_Homo sapiens_hsa051400.56338322
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56090242
121Hepatitis B_Homo sapiens_hsa051610.54669104
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53906645
123Sphingolipid metabolism_Homo sapiens_hsa006000.53688126
124Hematopoietic cell lineage_Homo sapiens_hsa046400.53670678
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53424836
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53116403
127Nitrogen metabolism_Homo sapiens_hsa009100.52655474
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50158191
129Purine metabolism_Homo sapiens_hsa002300.49769760
130Cell cycle_Homo sapiens_hsa041100.49507863
131Tyrosine metabolism_Homo sapiens_hsa003500.49227956
132DNA replication_Homo sapiens_hsa030300.48810268
133Oxidative phosphorylation_Homo sapiens_hsa001900.48132307
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48091623
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48038395
136Ovarian steroidogenesis_Homo sapiens_hsa049130.47822759
137Alzheimers disease_Homo sapiens_hsa050100.47614716
138Rheumatoid arthritis_Homo sapiens_hsa053230.47395233
139GABAergic synapse_Homo sapiens_hsa047270.45785975
140Antigen processing and presentation_Homo sapiens_hsa046120.44538970
141Apoptosis_Homo sapiens_hsa042100.44180480
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.43243488
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42104273
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41542931
145Pancreatic cancer_Homo sapiens_hsa052120.41438134
146Morphine addiction_Homo sapiens_hsa050320.41262837
147beta-Alanine metabolism_Homo sapiens_hsa004100.41182906
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40605143
149Sulfur metabolism_Homo sapiens_hsa009200.39465134
150Osteoclast differentiation_Homo sapiens_hsa043800.39183364
151Lysosome_Homo sapiens_hsa041420.38500804
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.38293565
153Arginine and proline metabolism_Homo sapiens_hsa003300.37983685
154Cardiac muscle contraction_Homo sapiens_hsa042600.36855541
155Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36352997
156Proteasome_Homo sapiens_hsa030500.35282364
157Melanogenesis_Homo sapiens_hsa049160.34761056
158RNA polymerase_Homo sapiens_hsa030200.32876590
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32529322
160Tight junction_Homo sapiens_hsa045300.32295116
161Viral carcinogenesis_Homo sapiens_hsa052030.31267119
162Basal transcription factors_Homo sapiens_hsa030220.31221572
163Starch and sucrose metabolism_Homo sapiens_hsa005000.30595984
164Salmonella infection_Homo sapiens_hsa051320.30197843
165Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30063399

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