

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | COPI coating of Golgi vesicle (GO:0048205) | 6.32376613 |
| 2 | Golgi transport vesicle coating (GO:0048200) | 6.32376613 |
| 3 | collagen fibril organization (GO:0030199) | 5.82714269 |
| 4 | protein heterotrimerization (GO:0070208) | 5.46260465 |
| 5 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 5.14983371 |
| 6 | protein retention in ER lumen (GO:0006621) | 4.76696056 |
| 7 | chondrocyte proliferation (GO:0035988) | 4.36790789 |
| 8 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 4.26417389 |
| 9 | hemidesmosome assembly (GO:0031581) | 4.24760052 |
| 10 | bone trabecula formation (GO:0060346) | 4.18293587 |
| 11 | peptidyl-proline hydroxylation (GO:0019511) | 4.12658739 |
| 12 | collagen metabolic process (GO:0032963) | 4.10273250 |
| 13 | collagen catabolic process (GO:0030574) | 4.05739044 |
| 14 | keratan sulfate catabolic process (GO:0042340) | 3.98748552 |
| 15 | endodermal cell differentiation (GO:0035987) | 3.98727502 |
| 16 | type B pancreatic cell proliferation (GO:0044342) | 3.98705284 |
| 17 | chondrocyte development (GO:0002063) | 3.97050573 |
| 18 | cellular response to vitamin (GO:0071295) | 3.94592672 |
| 19 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 3.89488680 |
| 20 | cell migration involved in heart development (GO:0060973) | 3.89446283 |
| 21 | COPII vesicle coating (GO:0048208) | 3.88852363 |
| 22 | cellular response to vitamin D (GO:0071305) | 3.88269495 |
| 23 | multicellular organismal macromolecule metabolic process (GO:0044259) | 3.86749764 |
| 24 | extracellular fibril organization (GO:0043206) | 3.84654526 |
| 25 | multicellular organismal catabolic process (GO:0044243) | 3.79964085 |
| 26 | protein hydroxylation (GO:0018126) | 3.77483183 |
| 27 | multicellular organismal metabolic process (GO:0044236) | 3.73074172 |
| 28 | positive regulation of nuclease activity (GO:0032075) | 3.70373348 |
| 29 | basement membrane organization (GO:0071711) | 3.63625960 |
| 30 | skin morphogenesis (GO:0043589) | 3.63271155 |
| 31 | polarized epithelial cell differentiation (GO:0030859) | 3.61903127 |
| 32 | extracellular matrix disassembly (GO:0022617) | 3.60150672 |
| 33 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 3.58979212 |
| 34 | regulation of integrin-mediated signaling pathway (GO:2001044) | 3.56929304 |
| 35 | desmosome organization (GO:0002934) | 3.53852846 |
| 36 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 3.42227150 |
| 37 | regulation of branching involved in salivary gland morphogenesis (GO:0060693) | 3.40196198 |
| 38 | kidney mesenchyme development (GO:0072074) | 3.38194683 |
| 39 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 3.37409746 |
| 40 | endoplasmic reticulum unfolded protein response (GO:0030968) | 3.36823995 |
| 41 | 4-hydroxyproline metabolic process (GO:0019471) | 3.32929875 |
| 42 | regulation of nuclease activity (GO:0032069) | 3.31936937 |
| 43 | metanephric mesenchyme development (GO:0072075) | 3.31891379 |
| 44 | endothelial cell morphogenesis (GO:0001886) | 3.29171656 |
| 45 | negative regulation of chondrocyte differentiation (GO:0032331) | 3.28227676 |
| 46 | negative regulation of cartilage development (GO:0061037) | 3.27249877 |
| 47 | extracellular matrix assembly (GO:0085029) | 3.27245085 |
| 48 | cellular response to unfolded protein (GO:0034620) | 3.24241446 |
| 49 | apoptotic cell clearance (GO:0043277) | 3.23845058 |
| 50 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 3.17965912 |
| 51 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.14358469 |
| 52 | type B pancreatic cell development (GO:0003323) | 3.13745367 |
| 53 | sequestering of extracellular ligand from receptor (GO:0035581) | 3.13284135 |
| 54 | fibril organization (GO:0097435) | 3.12731980 |
| 55 | exocrine pancreas development (GO:0031017) | 3.12371261 |
| 56 | epithelial cell-cell adhesion (GO:0090136) | 3.11839778 |
| 57 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 3.11226489 |
| 58 | ER-nucleus signaling pathway (GO:0006984) | 3.10480752 |
| 59 | smooth muscle tissue development (GO:0048745) | 3.09806748 |
| 60 | negative regulation of fatty acid transport (GO:2000192) | 3.09577657 |
| 61 | blood vessel maturation (GO:0001955) | 3.07280126 |
| 62 | hippo signaling (GO:0035329) | 3.05224889 |
| 63 | cell adhesion mediated by integrin (GO:0033627) | 3.03838681 |
| 64 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.01764002 |
| 65 | cellular response to topologically incorrect protein (GO:0035967) | 3.00867214 |
| 66 | glomerular basement membrane development (GO:0032836) | 2.94488027 |
| 67 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.94011337 |
| 68 | glandular epithelial cell development (GO:0002068) | 2.90832895 |
| 69 | positive regulation of hormone biosynthetic process (GO:0046886) | 2.88192345 |
| 70 | substrate-dependent cell migration (GO:0006929) | 2.87107773 |
| 71 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.86455962 |
| 72 | axon extension involved in axon guidance (GO:0048846) | 2.86455962 |
| 73 | cell aggregation (GO:0098743) | 2.85531789 |
| 74 | cartilage condensation (GO:0001502) | 2.85531789 |
| 75 | vesicle coating (GO:0006901) | 2.85443104 |
| 76 | plasma membrane repair (GO:0001778) | 2.84667557 |
| 77 | paraxial mesoderm development (GO:0048339) | 2.83481097 |
| 78 | endocardial cushion development (GO:0003197) | 2.81752656 |
| 79 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.80789942 |
| 80 | cell migration involved in sprouting angiogenesis (GO:0002042) | 2.80319961 |
| 81 | protein maturation by protein folding (GO:0022417) | 2.78163956 |
| 82 | establishment of apical/basal cell polarity (GO:0035089) | 2.77715528 |
| 83 | dorsal/ventral axis specification (GO:0009950) | 2.77357726 |
| 84 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800) | 2.75619537 |
| 85 | cell-substrate junction assembly (GO:0007044) | 2.75171289 |
| 86 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.74804514 |
| 87 | extracellular matrix organization (GO:0030198) | 2.74030222 |
| 88 | extracellular structure organization (GO:0043062) | 2.73156829 |
| 89 | extracellular negative regulation of signal transduction (GO:1900116) | 2.70024852 |
| 90 | extracellular regulation of signal transduction (GO:1900115) | 2.70024852 |
| 91 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 2.69799813 |
| 92 | regulation of SMAD protein import into nucleus (GO:0060390) | 2.69102134 |
| 93 | endochondral ossification (GO:0001958) | 2.67261448 |
| 94 | replacement ossification (GO:0036075) | 2.67261448 |
| 95 | adhesion of symbiont to host cell (GO:0044650) | 2.67054263 |
| 96 | virion attachment to host cell (GO:0019062) | 2.67054263 |
| 97 | response to endoplasmic reticulum stress (GO:0034976) | 2.65541985 |
| 98 | positive regulation of glycogen biosynthetic process (GO:0045725) | 2.64252030 |
| 99 | outer ear morphogenesis (GO:0042473) | 2.62698749 |
| 100 | response to unfolded protein (GO:0006986) | 2.62558106 |
| 101 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 2.62527674 |
| 102 | mesenchymal-epithelial cell signaling (GO:0060638) | 2.61982535 |
| 103 | regulation of heart morphogenesis (GO:2000826) | 2.61929439 |
| 104 | cellular response to nutrient (GO:0031670) | 2.60898160 |
| 105 | barbed-end actin filament capping (GO:0051016) | 2.60689149 |
| 106 | positive regulation of actin filament depolymerization (GO:0030836) | 2.60212857 |
| 107 | regulation of chondrocyte differentiation (GO:0032330) | 2.60138134 |
| 108 | regulation of cartilage development (GO:0061035) | 2.60094111 |
| 109 | negative regulation of catenin import into nucleus (GO:0035414) | 2.58570388 |
| 110 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.58419343 |
| 111 | convergent extension (GO:0060026) | 2.57826262 |
| 112 | wound healing, spreading of epidermal cells (GO:0035313) | 2.57579535 |
| 113 | embryonic cranial skeleton morphogenesis (GO:0048701) | 2.57411824 |
| 114 | craniofacial suture morphogenesis (GO:0097094) | 2.57117420 |
| 115 | glycoprotein catabolic process (GO:0006516) | 2.57082725 |
| 116 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.57010818 |
| 117 | notochord development (GO:0030903) | 2.56007035 |
| 118 | renal filtration (GO:0097205) | 2.55324111 |
| 119 | regulation of extracellular matrix disassembly (GO:0010715) | 2.55224190 |
| 120 | regulation of transforming growth factor beta2 production (GO:0032909) | 2.53657741 |
| 121 | positive regulation of extracellular matrix organization (GO:1903055) | 2.52490677 |
| 122 | positive regulation of osteoblast proliferation (GO:0033690) | 2.51247016 |
| 123 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.50877737 |
| 124 | dermatan sulfate biosynthetic process (GO:0030208) | 2.50222551 |
| 125 | trabecula formation (GO:0060343) | 2.49928984 |
| 126 | negative regulation of stem cell proliferation (GO:2000647) | 2.49247479 |
| 127 | face morphogenesis (GO:0060325) | 2.49002741 |
| 128 | regulation of hippo signaling (GO:0035330) | 2.47957195 |
| 129 | positive regulation of cartilage development (GO:0061036) | 2.46989480 |
| 130 | protein localization to cell surface (GO:0034394) | 2.46870818 |
| 131 | regulation of type B pancreatic cell apoptotic process (GO:2000674) | 2.46740586 |
| 132 | response to topologically incorrect protein (GO:0035966) | 2.46322423 |
| 133 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.45602915 |
| 134 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.45094875 |
| 135 | muscle cell migration (GO:0014812) | 2.44774654 |
| 136 | cellular response to amino acid stimulus (GO:0071230) | 2.43781568 |
| 137 | regulation of metalloenzyme activity (GO:0048552) | 2.43523919 |
| 138 | positive regulation of mesenchymal cell proliferation (GO:0002053) | 2.43105487 |
| 139 | negative regulation of axon guidance (GO:1902668) | 2.43055461 |
| 140 | heparan sulfate proteoglycan biosynthetic process (GO:0015012) | 2.42153269 |
| 141 | regulation of plasminogen activation (GO:0010755) | 2.40911735 |
| 142 | dermatan sulfate metabolic process (GO:0030205) | 2.40414426 |
| 143 | regulation of axon guidance (GO:1902667) | 2.40260047 |
| 144 | fibroblast migration (GO:0010761) | 2.39882165 |
| 145 | actin filament depolymerization (GO:0030042) | 2.39343122 |
| 146 | venous blood vessel morphogenesis (GO:0048845) | 2.38652179 |
| 147 | glomerular visceral epithelial cell development (GO:0072015) | 2.38115895 |
| 148 | positive regulation of fibroblast migration (GO:0010763) | 2.37991537 |
| 149 | adhesion of symbiont to host (GO:0044406) | 2.37936845 |
| 150 | sprouting angiogenesis (GO:0002040) | 2.37324546 |
| 151 | negative regulation of BMP signaling pathway (GO:0030514) | 2.36795750 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 6.46358227 |
| 2 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 5.75647177 |
| 3 | CLOCK_20551151_ChIP-Seq_293T_Human | 3.98650660 |
| 4 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 3.89801025 |
| 5 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.80222953 |
| 6 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.66845964 |
| 7 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.65639810 |
| 8 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.63024995 |
| 9 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.60930629 |
| 10 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 2.55226491 |
| 11 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.45730087 |
| 12 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 2.45378681 |
| 13 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 2.38201931 |
| 14 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.37038228 |
| 15 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.36746617 |
| 16 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 2.26678578 |
| 17 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.21270179 |
| 18 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.18972233 |
| 19 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 2.14214726 |
| 20 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.03082580 |
| 21 | TP53_18474530_ChIP-ChIP_U2OS_Human | 2.00900561 |
| 22 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 2.00167837 |
| 23 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.97273850 |
| 24 | CJUN_26792858_Chip-Seq_BT549_Human | 1.95560410 |
| 25 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.92135604 |
| 26 | * BRD4_25478319_ChIP-Seq_HGPS_Human | 1.89737270 |
| 27 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.86557849 |
| 28 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.84414017 |
| 29 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.82980346 |
| 30 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.82940337 |
| 31 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.79645083 |
| 32 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.78556436 |
| 33 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.77015998 |
| 34 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.71997994 |
| 35 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.70631669 |
| 36 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.66080774 |
| 37 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.63296620 |
| 38 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.61260850 |
| 39 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.57949375 |
| 40 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.57149506 |
| 41 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.56692423 |
| 42 | TP53_16413492_ChIP-PET_HCT116_Human | 1.56440657 |
| 43 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.54725969 |
| 44 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.52922885 |
| 45 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.52704909 |
| 46 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.52704909 |
| 47 | ATF3_27146783_Chip-Seq_COLON_Human | 1.50434899 |
| 48 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.49942192 |
| 49 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.48990502 |
| 50 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.46023660 |
| 51 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.43931901 |
| 52 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.43931901 |
| 53 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.43693099 |
| 54 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.43619390 |
| 55 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.43103026 |
| 56 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.43103026 |
| 57 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.43103026 |
| 58 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.41381626 |
| 59 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.37702808 |
| 60 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.37702808 |
| 61 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.37569325 |
| 62 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.37210091 |
| 63 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.37199183 |
| 64 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.34003366 |
| 65 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.33911281 |
| 66 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.33476887 |
| 67 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.31958402 |
| 68 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.31710826 |
| 69 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.31246360 |
| 70 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.30929061 |
| 71 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.30927406 |
| 72 | * FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 1.30234397 |
| 73 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.29407453 |
| 74 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.28854106 |
| 75 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.28658292 |
| 76 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.28580947 |
| 77 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.28153382 |
| 78 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.26989337 |
| 79 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.26459026 |
| 80 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.25444424 |
| 81 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.23885922 |
| 82 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.23153310 |
| 83 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.22368175 |
| 84 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.21098860 |
| 85 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.20500562 |
| 86 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.20150036 |
| 87 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.19894654 |
| 88 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.19842614 |
| 89 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.19842614 |
| 90 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.19812000 |
| 91 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.19307998 |
| 92 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.18473816 |
| 93 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.16189964 |
| 94 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.15491272 |
| 95 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.14894936 |
| 96 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.14652262 |
| 97 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.14156644 |
| 98 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.11354602 |
| 99 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.10985636 |
| 100 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.10501478 |
| 101 | TP63_23658742_ChIP-Seq_EP156T_Human | 1.10425650 |
| 102 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.10248128 |
| 103 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.09690513 |
| 104 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.09627983 |
| 105 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.09420395 |
| 106 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.08064271 |
| 107 | * TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.04751095 |
| 108 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.04081719 |
| 109 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.03749803 |
| 110 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.03206722 |
| 111 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.02784619 |
| 112 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.02257816 |
| 113 | SA1_22415368_ChIP-Seq_MEFs_Mouse | 1.01954666 |
| 114 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 1.01924378 |
| 115 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.01100636 |
| 116 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.01089785 |
| 117 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.01022085 |
| 118 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.01017947 |
| 119 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.00808972 |
| 120 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.98485616 |
| 121 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.97969367 |
| 122 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.96631795 |
| 123 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.96023859 |
| 124 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.95561962 |
| 125 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.95440837 |
| 126 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.94326776 |
| 127 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.94048567 |
| 128 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.93621255 |
| 129 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.92567565 |
| 130 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.92510116 |
| 131 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.91765735 |
| 132 | KDM2B_26808549_Chip-Seq_K562_Human | 0.90790518 |
| 133 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.90738918 |
| 134 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 0.90322943 |
| 135 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.90292506 |
| 136 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.89492899 |
| 137 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.88960242 |
| 138 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.88340979 |
| 139 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.87432377 |
| 140 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.87369913 |
| 141 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.85979482 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 6.52409896 |
| 2 | MP0005275_abnormal_skin_tensile | 4.17875346 |
| 3 | MP0005503_abnormal_tendon_morphology | 4.10502218 |
| 4 | MP0003705_abnormal_hypodermis_morpholog | 3.69725133 |
| 5 | MP0004272_abnormal_basement_membrane | 3.45238116 |
| 6 | MP0003283_abnormal_digestive_organ | 3.13284597 |
| 7 | MP0003950_abnormal_plasma_membrane | 2.51746089 |
| 8 | MP0002877_abnormal_melanocyte_morpholog | 2.49070358 |
| 9 | MP0005623_abnormal_meninges_morphology | 2.47020068 |
| 10 | MP0003279_aneurysm | 2.42751431 |
| 11 | MP0006054_spinal_hemorrhage | 2.27194991 |
| 12 | MP0009384_cardiac_valve_regurgitation | 2.24713024 |
| 13 | MP0001958_emphysema | 2.10109924 |
| 14 | MP0000013_abnormal_adipose_tissue | 2.05432444 |
| 15 | MP0005508_abnormal_skeleton_morphology | 2.02328544 |
| 16 | MP0002896_abnormal_bone_mineralization | 1.98609439 |
| 17 | MP0009780_abnormal_chondrocyte_physiolo | 1.90516365 |
| 18 | MP0003566_abnormal_cell_adhesion | 1.83393591 |
| 19 | MP0005257_abnormal_intraocular_pressure | 1.81870011 |
| 20 | MP0002060_abnormal_skin_morphology | 1.63507994 |
| 21 | MP0010030_abnormal_orbit_morphology | 1.58916319 |
| 22 | MP0009250_abnormal_appendicular_skeleto | 1.56752519 |
| 23 | MP0001299_abnormal_eye_distance/ | 1.56041150 |
| 24 | MP0002108_abnormal_muscle_morphology | 1.55891719 |
| 25 | MP0000163_abnormal_cartilage_morphology | 1.52446661 |
| 26 | MP0010352_gastrointestinal_tract_polyps | 1.49725745 |
| 27 | MP0004134_abnormal_chest_morphology | 1.47715259 |
| 28 | MP0000003_abnormal_adipose_tissue | 1.38592495 |
| 29 | MP0003942_abnormal_urinary_system | 1.34501301 |
| 30 | MP0000428_abnormal_craniofacial_morphol | 1.34317551 |
| 31 | MP0002115_abnormal_skeleton_extremities | 1.34051912 |
| 32 | MP0002295_abnormal_pulmonary_circulatio | 1.32597192 |
| 33 | MP0004084_abnormal_cardiac_muscle | 1.32145007 |
| 34 | MP0003385_abnormal_body_wall | 1.31627046 |
| 35 | MP0003941_abnormal_skin_development | 1.29982291 |
| 36 | MP0005023_abnormal_wound_healing | 1.29636098 |
| 37 | MP0000749_muscle_degeneration | 1.29158407 |
| 38 | MP0000534_abnormal_ureter_morphology | 1.28476939 |
| 39 | MP0002837_dystrophic_cardiac_calcinosis | 1.26741774 |
| 40 | MP0000733_abnormal_muscle_development | 1.26516814 |
| 41 | MP0002282_abnormal_trachea_morphology | 1.26437465 |
| 42 | MP0000537_abnormal_urethra_morphology | 1.23278241 |
| 43 | MP0009053_abnormal_anal_canal | 1.22389222 |
| 44 | MP0004185_abnormal_adipocyte_glucose | 1.21817940 |
| 45 | MP0005076_abnormal_cell_differentiation | 1.18134353 |
| 46 | MP0005595_abnormal_vascular_smooth | 1.14866803 |
| 47 | MP0000751_myopathy | 1.11977822 |
| 48 | MP0002932_abnormal_joint_morphology | 1.10383883 |
| 49 | MP0003115_abnormal_respiratory_system | 1.09397591 |
| 50 | MP0003091_abnormal_cell_migration | 1.08900048 |
| 51 | MP0010386_abnormal_urinary_bladder | 1.08615673 |
| 52 | MP0000462_abnormal_digestive_system | 1.07222605 |
| 53 | MP0001542_abnormal_bone_strength | 1.06781519 |
| 54 | MP0002113_abnormal_skeleton_development | 1.05578901 |
| 55 | MP0000762_abnormal_tongue_morphology | 1.04231980 |
| 56 | MP0005375_adipose_tissue_phenotype | 1.03362385 |
| 57 | MP0002933_joint_inflammation | 1.02969607 |
| 58 | MP0005220_abnormal_exocrine_pancreas | 1.02867674 |
| 59 | MP0010368_abnormal_lymphatic_system | 1.01215707 |
| 60 | MP0004858_abnormal_nervous_system | 0.99597271 |
| 61 | MP0001243_abnormal_dermal_layer | 0.99189599 |
| 62 | MP0003935_abnormal_craniofacial_develop | 0.98843106 |
| 63 | MP0003119_abnormal_digestive_system | 0.98113184 |
| 64 | MP0000538_abnormal_urinary_bladder | 0.98087627 |
| 65 | MP0005390_skeleton_phenotype | 0.97294180 |
| 66 | MP0003755_abnormal_palate_morphology | 0.97230466 |
| 67 | MP0010234_abnormal_vibrissa_follicle | 0.96825274 |
| 68 | MP0002089_abnormal_postnatal_growth/wei | 0.95868835 |
| 69 | MP0003937_abnormal_limbs/digits/tail_de | 0.94995854 |
| 70 | MP0000767_abnormal_smooth_muscle | 0.94855275 |
| 71 | MP0005248_abnormal_Harderian_gland | 0.94801724 |
| 72 | MP0000516_abnormal_urinary_system | 0.93633973 |
| 73 | MP0005367_renal/urinary_system_phenotyp | 0.93633973 |
| 74 | MP0002111_abnormal_tail_morphology | 0.93322488 |
| 75 | MP0001849_ear_inflammation | 0.92906858 |
| 76 | MP0003122_maternal_imprinting | 0.92759114 |
| 77 | MP0000467_abnormal_esophagus_morphology | 0.92132101 |
| 78 | MP0001944_abnormal_pancreas_morphology | 0.91959993 |
| 79 | MP0002168_other_aberrant_phenotype | 0.91911692 |
| 80 | MP0004197_abnormal_fetal_growth/weight/ | 0.91733534 |
| 81 | MP0002116_abnormal_craniofacial_bone | 0.91273663 |
| 82 | MP0003045_fibrosis | 0.91169602 |
| 83 | MP0002109_abnormal_limb_morphology | 0.90251445 |
| 84 | MP0002234_abnormal_pharynx_morphology | 0.90106605 |
| 85 | MP0005197_abnormal_uvea_morphology | 0.89366349 |
| 86 | MP0000750_abnormal_muscle_regeneration | 0.89345337 |
| 87 | MP0000432_abnormal_head_morphology | 0.88912943 |
| 88 | MP0005666_abnormal_adipose_tissue | 0.88721818 |
| 89 | MP0003123_paternal_imprinting | 0.86760682 |
| 90 | MP0000049_abnormal_middle_ear | 0.85549219 |
| 91 | MP0000678_abnormal_parathyroid_gland | 0.85193806 |
| 92 | MP0002233_abnormal_nose_morphology | 0.81645787 |
| 93 | MP0006138_congestive_heart_failure | 0.81632397 |
| 94 | MP0004233_abnormal_muscle_weight | 0.80798378 |
| 95 | MP0000759_abnormal_skeletal_muscle | 0.79673468 |
| 96 | MP0001661_extended_life_span | 0.78904312 |
| 97 | MP0003795_abnormal_bone_structure | 0.78333314 |
| 98 | MP0004087_abnormal_muscle_fiber | 0.77599644 |
| 99 | MP0005165_increased_susceptibility_to | 0.77537916 |
| 100 | MP0005171_absent_coat_pigmentation | 0.76625551 |
| 101 | MP0001270_distended_abdomen | 0.75982007 |
| 102 | MP0005408_hypopigmentation | 0.75596493 |
| 103 | MP0002697_abnormal_eye_size | 0.75277969 |
| 104 | MP0001879_abnormal_lymphatic_vessel | 0.74281740 |
| 105 | MP0003300_gastrointestinal_ulcer | 0.74180968 |
| 106 | MP0002249_abnormal_larynx_morphology | 0.73685529 |
| 107 | MP0005164_abnormal_response_to | 0.73478692 |
| 108 | MP0002925_abnormal_cardiovascular_devel | 0.71565574 |
| 109 | MP0008775_abnormal_heart_ventricle | 0.71527551 |
| 110 | MP0002128_abnormal_blood_circulation | 0.71030802 |
| 111 | MP0005409_darkened_coat_color | 0.70803367 |
| 112 | MP0003878_abnormal_ear_physiology | 0.70525069 |
| 113 | MP0005377_hearing/vestibular/ear_phenot | 0.70525069 |
| 114 | MP0010771_integument_phenotype | 0.70333367 |
| 115 | MP0005670_abnormal_white_adipose | 0.69889717 |
| 116 | MP0001614_abnormal_blood_vessel | 0.69231409 |
| 117 | MP0004036_abnormal_muscle_relaxation | 0.69058114 |
| 118 | MP0005193_abnormal_anterior_eye | 0.64844272 |
| 119 | MP0005330_cardiomyopathy | 0.62119869 |
| 120 | MP0001915_intracranial_hemorrhage | 0.62022517 |
| 121 | MP0002177_abnormal_outer_ear | 0.61960455 |
| 122 | MP0005369_muscle_phenotype | 0.58386175 |
| 123 | MP0005620_abnormal_muscle_contractility | 0.57936139 |
| 124 | MP0002114_abnormal_axial_skeleton | 0.57468278 |
| 125 | MP0001348_abnormal_lacrimal_gland | 0.57349362 |
| 126 | MP0001756_abnormal_urination | 0.56684827 |
| 127 | MP0005360_urolithiasis | 0.56308047 |
| 128 | MP0003191_abnormal_cellular_cholesterol | 0.55313989 |
| 129 | MP0002269_muscular_atrophy | 0.53874273 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protrusio acetabuli (HP:0003179) | 6.46441388 |
| 2 | Premature rupture of membranes (HP:0001788) | 6.06036199 |
| 3 | Ankle contracture (HP:0006466) | 4.38107740 |
| 4 | Epiphyseal dysplasia (HP:0002656) | 4.03459613 |
| 5 | Cervical subluxation (HP:0003308) | 3.90342965 |
| 6 | Hypoplastic ischia (HP:0003175) | 3.76310765 |
| 7 | Neonatal short-limb short stature (HP:0008921) | 3.65290729 |
| 8 | Aortic dissection (HP:0002647) | 3.62574436 |
| 9 | Shallow orbits (HP:0000586) | 3.60228249 |
| 10 | Soft skin (HP:0000977) | 3.54472122 |
| 11 | Cerebral aneurysm (HP:0004944) | 3.51348112 |
| 12 | Atrophic scars (HP:0001075) | 3.44405594 |
| 13 | Abnormality of dentin (HP:0010299) | 3.43840656 |
| 14 | Abnormality of the ischium (HP:0003174) | 3.35097163 |
| 15 | Bladder diverticulum (HP:0000015) | 3.27092475 |
| 16 | Broad metatarsal (HP:0001783) | 3.26618335 |
| 17 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 3.08136199 |
| 18 | Follicular hyperkeratosis (HP:0007502) | 3.08030364 |
| 19 | Type 1 muscle fiber predominance (HP:0003803) | 3.05669846 |
| 20 | Spinal rigidity (HP:0003306) | 3.01114238 |
| 21 | Spondylolisthesis (HP:0003302) | 2.92555055 |
| 22 | Aortic aneurysm (HP:0004942) | 2.90912604 |
| 23 | Wormian bones (HP:0002645) | 2.85840638 |
| 24 | Blue sclerae (HP:0000592) | 2.85317904 |
| 25 | Fragile skin (HP:0001030) | 2.83655936 |
| 26 | Osteoarthritis (HP:0002758) | 2.83039182 |
| 27 | Mitral valve prolapse (HP:0001634) | 2.80029951 |
| 28 | Genu recurvatum (HP:0002816) | 2.77147757 |
| 29 | Peritonitis (HP:0002586) | 2.71787532 |
| 30 | Dilatation of the ascending aorta (HP:0005111) | 2.71610350 |
| 31 | Mild short stature (HP:0003502) | 2.70460763 |
| 32 | Cupped ribs (HP:0000887) | 2.70229806 |
| 33 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.68027071 |
| 34 | Osteolytic defects of the hand bones (HP:0009699) | 2.68027071 |
| 35 | Platyspondyly (HP:0000926) | 2.63589435 |
| 36 | Mitral stenosis (HP:0001718) | 2.62554712 |
| 37 | Vitreoretinal degeneration (HP:0000655) | 2.60870833 |
| 38 | Metaphyseal cupping (HP:0003021) | 2.55857963 |
| 39 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.53392215 |
| 40 | Increased connective tissue (HP:0009025) | 2.52367895 |
| 41 | Cardiovascular calcification (HP:0011915) | 2.47627070 |
| 42 | Aortic regurgitation (HP:0001659) | 2.41911862 |
| 43 | Bell-shaped thorax (HP:0001591) | 2.39537535 |
| 44 | Abnormality of the acetabulum (HP:0003170) | 2.37777193 |
| 45 | Exostoses (HP:0100777) | 2.35275775 |
| 46 | Popliteal pterygium (HP:0009756) | 2.33705788 |
| 47 | Hyperextensible skin (HP:0000974) | 2.33146478 |
| 48 | Aneurysm (HP:0002617) | 2.30617371 |
| 49 | Vertebral compression fractures (HP:0002953) | 2.28233686 |
| 50 | Breech presentation (HP:0001623) | 2.25747447 |
| 51 | Bowel diverticulosis (HP:0005222) | 2.22642108 |
| 52 | Mesomelia (HP:0003027) | 2.21236519 |
| 53 | Coronal craniosynostosis (HP:0004440) | 2.21224354 |
| 54 | Thoracolumbar scoliosis (HP:0002944) | 2.20878712 |
| 55 | Abnormal vertebral ossification (HP:0100569) | 2.20502418 |
| 56 | Irregular epiphyses (HP:0010582) | 2.19520548 |
| 57 | Biconcave vertebral bodies (HP:0004586) | 2.19401436 |
| 58 | Delayed gross motor development (HP:0002194) | 2.18943697 |
| 59 | Aortic valve stenosis (HP:0001650) | 2.18561667 |
| 60 | Flat acetabular roof (HP:0003180) | 2.18131279 |
| 61 | Vascular tortuosity (HP:0004948) | 2.17631514 |
| 62 | Infantile muscular hypotonia (HP:0008947) | 2.16219274 |
| 63 | Mitral regurgitation (HP:0001653) | 2.15341420 |
| 64 | Ulnar bowing (HP:0003031) | 2.14027128 |
| 65 | Natal tooth (HP:0000695) | 2.13964144 |
| 66 | Absent frontal sinuses (HP:0002688) | 2.13447026 |
| 67 | Round ear (HP:0100830) | 2.10476042 |
| 68 | Increased variability in muscle fiber diameter (HP:0003557) | 2.08170560 |
| 69 | Coxa vara (HP:0002812) | 2.08013496 |
| 70 | Beaking of vertebral bodies (HP:0004568) | 2.06002343 |
| 71 | Joint laxity (HP:0001388) | 2.05560670 |
| 72 | Small epiphyses (HP:0010585) | 2.05435087 |
| 73 | Hypoplasia of the iris (HP:0007676) | 2.05399876 |
| 74 | Wide anterior fontanel (HP:0000260) | 2.04385256 |
| 75 | Pterygium (HP:0001059) | 2.03159345 |
| 76 | Radial bowing (HP:0002986) | 2.03069119 |
| 77 | Wrist flexion contracture (HP:0001239) | 2.02644428 |
| 78 | Thin bony cortex (HP:0002753) | 2.01982994 |
| 79 | Broad long bones (HP:0005622) | 2.01251889 |
| 80 | Tibial bowing (HP:0002982) | 2.00269234 |
| 81 | Overgrowth (HP:0001548) | 1.99292918 |
| 82 | Alopecia of scalp (HP:0002293) | 1.99041768 |
| 83 | Elbow flexion contracture (HP:0002987) | 1.98695645 |
| 84 | Arterial tortuosity (HP:0005116) | 1.97975221 |
| 85 | Asymmetry of the thorax (HP:0001555) | 1.94700750 |
| 86 | Ectopia lentis (HP:0001083) | 1.92778662 |
| 87 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.92725279 |
| 88 | Vertebral clefting (HP:0008428) | 1.92313395 |
| 89 | Rhizomelia (HP:0008905) | 1.90749135 |
| 90 | Delayed epiphyseal ossification (HP:0002663) | 1.90283357 |
| 91 | Broad ribs (HP:0000885) | 1.88753622 |
| 92 | Slender build (HP:0001533) | 1.88347455 |
| 93 | Femoral bowing (HP:0002980) | 1.87143328 |
| 94 | Buphthalmos (HP:0000557) | 1.87041452 |
| 95 | Protuberant abdomen (HP:0001538) | 1.86769472 |
| 96 | Joint stiffness (HP:0001387) | 1.86595850 |
| 97 | Limited hip movement (HP:0008800) | 1.86444461 |
| 98 | Keratoconus (HP:0000563) | 1.86407748 |
| 99 | Increased corneal curvature (HP:0100692) | 1.86407748 |
| 100 | Hip contracture (HP:0003273) | 1.85209447 |
| 101 | Abnormality of the calcaneus (HP:0008364) | 1.84565596 |
| 102 | Hypoventilation (HP:0002791) | 1.84143633 |
| 103 | Abnormal delivery (HP:0001787) | 1.84001237 |
| 104 | Lymphangioma (HP:0100764) | 1.82781336 |
| 105 | Deviation of the hallux (HP:0010051) | 1.82295720 |
| 106 | Protruding ear (HP:0000411) | 1.82067996 |
| 107 | Striae distensae (HP:0001065) | 1.82016883 |
| 108 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.81984132 |
| 109 | Congenital glaucoma (HP:0001087) | 1.80946296 |
| 110 | Knee flexion contracture (HP:0006380) | 1.80193265 |
| 111 | Spinal cord compression (HP:0002176) | 1.79333355 |
| 112 | Bowed forearm bones (HP:0003956) | 1.79153642 |
| 113 | Bowing of the arm (HP:0006488) | 1.79153642 |
| 114 | Hypoglycemic coma (HP:0001325) | 1.77959422 |
| 115 | Nonimmune hydrops fetalis (HP:0001790) | 1.77694821 |
| 116 | Scapular winging (HP:0003691) | 1.76454468 |
| 117 | Pulmonary artery stenosis (HP:0004415) | 1.75331382 |
| 118 | Short nail (HP:0001799) | 1.74864048 |
| 119 | Thin ribs (HP:0000883) | 1.74515838 |
| 120 | Hallux valgus (HP:0001822) | 1.74351347 |
| 121 | Inguinal hernia (HP:0000023) | 1.74246327 |
| 122 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.73126365 |
| 123 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 1.72415506 |
| 124 | Vertebral hypoplasia (HP:0008417) | 1.72415506 |
| 125 | Upper limb amyotrophy (HP:0009129) | 1.72404120 |
| 126 | Distal upper limb amyotrophy (HP:0007149) | 1.72404120 |
| 127 | Broad phalanx (HP:0006009) | 1.72257574 |
| 128 | Vascular calcification (HP:0004934) | 1.72060913 |
| 129 | Hand muscle atrophy (HP:0009130) | 1.71580762 |
| 130 | Generalized amyotrophy (HP:0003700) | 1.71544437 |
| 131 | Ovoid vertebral bodies (HP:0003300) | 1.71203425 |
| 132 | Abnormal tarsal ossification (HP:0008369) | 1.70434500 |
| 133 | Long toe (HP:0010511) | 1.70225908 |
| 134 | Delayed cranial suture closure (HP:0000270) | 1.70125059 |
| 135 | Delayed closure of the anterior fontanelle (HP:0001476) | 1.67803744 |
| 136 | Bradycardia (HP:0001662) | 1.65051588 |
| 137 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.64977669 |
| 138 | Thin skin (HP:0000963) | 1.64806165 |
| 139 | Venous abnormality (HP:0002624) | 1.64749976 |
| 140 | Venous insufficiency (HP:0005293) | 1.60568690 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DDR2 | 5.54921003 |
| 2 | TRIB3 | 4.27647069 |
| 3 | PDGFRA | 3.35167135 |
| 4 | PKN2 | 3.34037979 |
| 5 | LATS1 | 3.28998310 |
| 6 | TTN | 2.80274708 |
| 7 | SIK1 | 2.44911447 |
| 8 | MET | 2.21122346 |
| 9 | ERN1 | 2.15860101 |
| 10 | PASK | 2.15381673 |
| 11 | INSRR | 2.00962247 |
| 12 | RIPK1 | 1.95668095 |
| 13 | FLT3 | 1.88075226 |
| 14 | PTK6 | 1.83819601 |
| 15 | PRKD3 | 1.79353076 |
| 16 | FRK | 1.65664420 |
| 17 | FER | 1.63794577 |
| 18 | LATS2 | 1.63758536 |
| 19 | MAP3K12 | 1.63652963 |
| 20 | MUSK | 1.63271905 |
| 21 | PTK2 | 1.62311781 |
| 22 | EPHA3 | 1.57497287 |
| 23 | MAP3K3 | 1.55874816 |
| 24 | AKT3 | 1.51117618 |
| 25 | EPHA2 | 1.49571354 |
| 26 | PAK2 | 1.44247119 |
| 27 | STK38L | 1.42798739 |
| 28 | EPHB2 | 1.40536475 |
| 29 | PAK3 | 1.38996590 |
| 30 | STK3 | 1.28339895 |
| 31 | PAK4 | 1.27993710 |
| 32 | FGFR1 | 1.23745671 |
| 33 | SCYL2 | 1.22563376 |
| 34 | ERBB4 | 1.21358980 |
| 35 | PLK2 | 1.19875467 |
| 36 | PDGFRB | 1.11694703 |
| 37 | BMX | 1.11337267 |
| 38 | MTOR | 1.09886765 |
| 39 | NTRK1 | 1.07213447 |
| 40 | EEF2K | 1.06434138 |
| 41 | TGFBR2 | 1.06276875 |
| 42 | STK38 | 1.05388297 |
| 43 | TRPM7 | 1.02525367 |
| 44 | WNK4 | 1.02226383 |
| 45 | ABL2 | 1.01224791 |
| 46 | LRRK2 | 0.99410434 |
| 47 | FGFR2 | 0.92715850 |
| 48 | ADRBK1 | 0.91158583 |
| 49 | MAP3K2 | 0.91129037 |
| 50 | EPHB1 | 0.90544820 |
| 51 | DMPK | 0.89074582 |
| 52 | PRKCE | 0.84724991 |
| 53 | RET | 0.84524392 |
| 54 | PAK6 | 0.83240340 |
| 55 | EIF2AK1 | 0.82690823 |
| 56 | STK39 | 0.80654057 |
| 57 | RPS6KA4 | 0.78833034 |
| 58 | ROCK1 | 0.78548737 |
| 59 | TESK1 | 0.77989295 |
| 60 | DYRK1B | 0.77570994 |
| 61 | NEK9 | 0.75931333 |
| 62 | TGFBR1 | 0.75593512 |
| 63 | PHKG2 | 0.73613558 |
| 64 | PHKG1 | 0.73613558 |
| 65 | ILK | 0.72585113 |
| 66 | MAP3K10 | 0.71580636 |
| 67 | MAPK15 | 0.71252116 |
| 68 | CAMK1D | 0.70883590 |
| 69 | MAP2K1 | 0.70724804 |
| 70 | TIE1 | 0.68162520 |
| 71 | CAMK2D | 0.66857262 |
| 72 | MST1R | 0.66394260 |
| 73 | FGFR4 | 0.66243190 |
| 74 | FGFR3 | 0.64979690 |
| 75 | CDC42BPA | 0.63739020 |
| 76 | ICK | 0.62658279 |
| 77 | GRK1 | 0.62636061 |
| 78 | BRSK2 | 0.62279351 |
| 79 | BCKDK | 0.61363446 |
| 80 | CDK12 | 0.60953260 |
| 81 | STK24 | 0.60064980 |
| 82 | CDK6 | 0.59396489 |
| 83 | PIK3CA | 0.59065942 |
| 84 | CAMK2G | 0.58732566 |
| 85 | GSK3A | 0.58102677 |
| 86 | PRKG2 | 0.57143293 |
| 87 | HIPK2 | 0.56389717 |
| 88 | PRKD1 | 0.55773922 |
| 89 | PRKD2 | 0.54878334 |
| 90 | NEK1 | 0.53762079 |
| 91 | LIMK1 | 0.53110477 |
| 92 | MYLK | 0.53012510 |
| 93 | GRK5 | 0.52056588 |
| 94 | EIF2AK3 | 0.50724995 |
| 95 | PIM2 | 0.50549738 |
| 96 | MAPKAPK3 | 0.50348699 |
| 97 | MAP2K3 | 0.50154913 |
| 98 | PRKCH | 0.49056925 |
| 99 | MELK | 0.47575253 |
| 100 | RPS6KB2 | 0.45966000 |
| 101 | PDK2 | 0.45747858 |
| 102 | TYRO3 | 0.45546803 |
| 103 | DAPK3 | 0.45090322 |
| 104 | ERBB3 | 0.45020613 |
| 105 | PDK4 | 0.44876634 |
| 106 | PDK3 | 0.44876634 |
| 107 | WNK1 | 0.44637433 |
| 108 | LMTK2 | 0.43814652 |
| 109 | INSR | 0.43435723 |
| 110 | PTK2B | 0.41438300 |
| 111 | BCR | 0.41089248 |
| 112 | JAK1 | 0.41024619 |
| 113 | RPS6KA2 | 0.40700458 |
| 114 | CDK8 | 0.40444724 |
| 115 | MOS | 0.40229202 |
| 116 | MAPKAPK5 | 0.38444316 |
| 117 | MAP2K2 | 0.36092909 |
| 118 | PIK3CG | 0.35798159 |
| 119 | MAPK7 | 0.34361556 |
| 120 | CAMKK2 | 0.33832886 |
| 121 | MAP3K6 | 0.33359941 |
| 122 | CAMK1G | 0.32769852 |
| 123 | CSNK1G1 | 0.32619675 |
| 124 | MAP3K8 | 0.32195802 |
| 125 | NUAK1 | 0.31141157 |
| 126 | SRC | 0.31105241 |
| 127 | IGF1R | 0.29225928 |
| 128 | ABL1 | 0.28748337 |
| 129 | TRIM28 | 0.28424585 |
| 130 | IRAK3 | 0.28171918 |
| 131 | PRKCI | 0.27747008 |
| 132 | MST4 | 0.27679784 |
| 133 | CSNK1A1L | 0.26993098 |
| 134 | KSR2 | 0.26390846 |
| 135 | MAP3K1 | 0.26286803 |
| 136 | ROCK2 | 0.26172656 |
| 137 | MAPK1 | 0.25142462 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 4.38707174 |
| 2 | Protein digestion and absorption_Homo sapiens_hsa04974 | 3.34944141 |
| 3 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 3.32781549 |
| 4 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 2.92543613 |
| 5 | Focal adhesion_Homo sapiens_hsa04510 | 2.86764226 |
| 6 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 2.81002584 |
| 7 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.95702597 |
| 8 | Protein export_Homo sapiens_hsa03060 | 1.87428474 |
| 9 | Bladder cancer_Homo sapiens_hsa05219 | 1.87339980 |
| 10 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.87327440 |
| 11 | Adherens junction_Homo sapiens_hsa04520 | 1.85015975 |
| 12 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.76252400 |
| 13 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.70333788 |
| 14 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.67894762 |
| 15 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.66070092 |
| 16 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.65661713 |
| 17 | Amoebiasis_Homo sapiens_hsa05146 | 1.64567234 |
| 18 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.62635945 |
| 19 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.54480877 |
| 20 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.54334400 |
| 21 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.52646523 |
| 22 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.50276742 |
| 23 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.41329528 |
| 24 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.34652876 |
| 25 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.31238001 |
| 26 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.30447978 |
| 27 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.27451654 |
| 28 | Tight junction_Homo sapiens_hsa04530 | 1.24351245 |
| 29 | Insulin resistance_Homo sapiens_hsa04931 | 1.24322925 |
| 30 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.21962815 |
| 31 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.20283283 |
| 32 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.18652168 |
| 33 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.18525208 |
| 34 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.12169979 |
| 35 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.11618537 |
| 36 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.10241791 |
| 37 | Prostate cancer_Homo sapiens_hsa05215 | 1.07751806 |
| 38 | Melanoma_Homo sapiens_hsa05218 | 1.05620792 |
| 39 | Lysine degradation_Homo sapiens_hsa00310 | 1.01213218 |
| 40 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.00200826 |
| 41 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.98036704 |
| 42 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.97310202 |
| 43 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.95481670 |
| 44 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.94355505 |
| 45 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.89971347 |
| 46 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.89651376 |
| 47 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.88652903 |
| 48 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.87936157 |
| 49 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.87182930 |
| 50 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.86142026 |
| 51 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.82049253 |
| 52 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.81462710 |
| 53 | Lysosome_Homo sapiens_hsa04142 | 0.81374291 |
| 54 | Pathways in cancer_Homo sapiens_hsa05200 | 0.81368487 |
| 55 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.80279830 |
| 56 | Melanogenesis_Homo sapiens_hsa04916 | 0.78221380 |
| 57 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.77976125 |
| 58 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.76209947 |
| 59 | Thyroid cancer_Homo sapiens_hsa05216 | 0.75037182 |
| 60 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.74776940 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.74728160 |
| 62 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.74128986 |
| 63 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.74099637 |
| 64 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.73965518 |
| 65 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.73753786 |
| 66 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.73496045 |
| 67 | Glioma_Homo sapiens_hsa05214 | 0.73063065 |
| 68 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.71999266 |
| 69 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.71771557 |
| 70 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.71030164 |
| 71 | Circadian rhythm_Homo sapiens_hsa04710 | 0.70679210 |
| 72 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.70531319 |
| 73 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.69339171 |
| 74 | Insulin secretion_Homo sapiens_hsa04911 | 0.67943996 |
| 75 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.67571694 |
| 76 | Endometrial cancer_Homo sapiens_hsa05213 | 0.66301381 |
| 77 | Mineral absorption_Homo sapiens_hsa04978 | 0.66147702 |
| 78 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.65649124 |
| 79 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.65631452 |
| 80 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.65365658 |
| 81 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.64368887 |
| 82 | Galactose metabolism_Homo sapiens_hsa00052 | 0.63859780 |
| 83 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.62789955 |
| 84 | Malaria_Homo sapiens_hsa05144 | 0.60848374 |
| 85 | Prion diseases_Homo sapiens_hsa05020 | 0.60211025 |
| 86 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.59798963 |
| 87 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.59685493 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.57948439 |
| 89 | Renin secretion_Homo sapiens_hsa04924 | 0.57885440 |
| 90 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.57142198 |
| 91 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.56623404 |
| 92 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.56017973 |
| 93 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.54894703 |
| 94 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.54457436 |
| 95 | HTLV-I infection_Homo sapiens_hsa05166 | 0.53902111 |
| 96 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.53624181 |
| 97 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53218019 |
| 98 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.52151111 |
| 99 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.52095122 |
| 100 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.50970820 |
| 101 | Platelet activation_Homo sapiens_hsa04611 | 0.49638601 |
| 102 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.48588460 |
| 103 | Endocytosis_Homo sapiens_hsa04144 | 0.48350766 |
| 104 | Other glycan degradation_Homo sapiens_hsa00511 | 0.48313513 |
| 105 | Viral myocarditis_Homo sapiens_hsa05416 | 0.47760369 |
| 106 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.46184036 |
| 107 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.45732568 |
| 108 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.45588631 |
| 109 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.45062494 |
| 110 | Axon guidance_Homo sapiens_hsa04360 | 0.45018103 |
| 111 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.44340395 |
| 112 | Colorectal cancer_Homo sapiens_hsa05210 | 0.43883753 |
| 113 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.43830882 |
| 114 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.43826913 |
| 115 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.43777737 |
| 116 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.43446773 |
| 117 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.43058525 |
| 118 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.42959874 |
| 119 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.42447997 |
| 120 | Gap junction_Homo sapiens_hsa04540 | 0.41944367 |
| 121 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.41615346 |
| 122 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.41525770 |
| 123 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.41485452 |
| 124 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.40086458 |
| 125 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.39112902 |
| 126 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.37466345 |
| 127 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.36986376 |
| 128 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.36302154 |
| 129 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.34884641 |

