FKBPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.57470817
2sperm motility (GO:0030317)8.35551675
3sperm-egg recognition (GO:0035036)7.81514519
4binding of sperm to zona pellucida (GO:0007339)7.49856500
5cell wall macromolecule metabolic process (GO:0044036)7.48516381
6cell wall macromolecule catabolic process (GO:0016998)7.48516381
7multicellular organism reproduction (GO:0032504)7.18650138
8cell-cell recognition (GO:0009988)6.92040599
9acrosome reaction (GO:0007340)6.82986447
10cilium or flagellum-dependent cell motility (GO:0001539)6.67850219
11piRNA metabolic process (GO:0034587)6.66546518
12axonemal dynein complex assembly (GO:0070286)6.58786366
13plasma membrane fusion (GO:0045026)6.56614631
14acrosome assembly (GO:0001675)6.51850602
15spermatid development (GO:0007286)6.38863928
16reproduction (GO:0000003)6.09218204
17epithelial cilium movement (GO:0003351)5.86950868
18regulation of cilium movement (GO:0003352)5.64001539
19male meiosis (GO:0007140)5.60199084
20motile cilium assembly (GO:0044458)5.55349428
21synaptonemal complex organization (GO:0070193)5.45504690
22synaptonemal complex assembly (GO:0007130)5.36731040
23ribosomal small subunit biogenesis (GO:0042274)5.03378551
24maturation of SSU-rRNA (GO:0030490)4.88541835
25single fertilization (GO:0007338)4.86059611
26negative regulation of inclusion body assembly (GO:0090084)4.67451031
27microtubule depolymerization (GO:0007019)4.60760097
28chaperone-mediated protein transport (GO:0072321)4.58698297
29cilium movement (GO:0003341)4.52073244
30viral transcription (GO:0019083)4.34541929
31DNA strand elongation involved in DNA replication (GO:0006271)4.34096191
32DNA strand elongation (GO:0022616)4.31491613
33spermatogenesis (GO:0007283)4.30575136
34fertilization (GO:0009566)4.30002584
35ribosomal large subunit biogenesis (GO:0042273)4.29913573
36male gamete generation (GO:0048232)4.29321816
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29107427
38telomere maintenance via semi-conservative replication (GO:0032201)4.26779613
39translational termination (GO:0006415)4.18794976
40DNA methylation involved in gamete generation (GO:0043046)4.15374512
41mitotic chromosome condensation (GO:0007076)4.13155344
42sperm capacitation (GO:0048240)4.05478783
43regulation of inclusion body assembly (GO:0090083)4.02313510
44gamete generation (GO:0007276)3.98089532
45male meiosis I (GO:0007141)3.97213420
46ribonucleoprotein complex biogenesis (GO:0022613)3.95872590
47DNA replication checkpoint (GO:0000076)3.92541543
48protein localization to kinetochore (GO:0034501)3.92193409
49meiotic nuclear division (GO:0007126)3.91600393
50ribosomal small subunit assembly (GO:0000028)3.91019532
51mitotic sister chromatid segregation (GO:0000070)3.90112228
52negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.85490027
53regulation of mitochondrial translation (GO:0070129)3.84792833
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.79651977
55chromosome condensation (GO:0030261)3.78316481
56cotranslational protein targeting to membrane (GO:0006613)3.72349845
57DNA deamination (GO:0045006)3.71013315
58meiosis I (GO:0007127)3.70375117
59regulation of mitotic spindle organization (GO:0060236)3.70222279
60protein targeting to ER (GO:0045047)3.70021394
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67711314
62seminiferous tubule development (GO:0072520)3.66163585
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.65570569
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.64946743
65chromosome organization involved in meiosis (GO:0070192)3.64713936
66translational elongation (GO:0006414)3.63863596
67microtubule severing (GO:0051013)3.63805688
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.61262745
69organic cation transport (GO:0015695)3.60951692
70meiotic cell cycle (GO:0051321)3.60256475
71DNA unwinding involved in DNA replication (GO:0006268)3.58724109
72viral life cycle (GO:0019058)3.57455055
73protein targeting to mitochondrion (GO:0006626)3.56536295
74establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55875926
75protein localization to endoplasmic reticulum (GO:0070972)3.51299914
76single strand break repair (GO:0000012)3.50069818
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49822918
78DNA packaging (GO:0006323)3.47687269
79translational initiation (GO:0006413)3.47456372
80germ cell development (GO:0007281)3.47178309
81ventricular cardiac muscle cell development (GO:0055015)3.46018816
82telomere maintenance via recombination (GO:0000722)3.45568756
83cellular component biogenesis (GO:0044085)3.45233101
84translation (GO:0006412)3.44375545
85DNA replication initiation (GO:0006270)3.43015252
86cellular process involved in reproduction in multicellular organism (GO:0022412)3.42191006
87energy coupled proton transport, down electrochemical gradient (GO:0015985)3.41728507
88ATP synthesis coupled proton transport (GO:0015986)3.41728507
89sister chromatid segregation (GO:0000819)3.41414997
90mitotic metaphase plate congression (GO:0007080)3.40426517
91protein maturation by protein folding (GO:0022417)3.37527555
92monoubiquitinated protein deubiquitination (GO:0035520)3.36650325
93rRNA processing (GO:0006364)3.36528803
94cellular protein complex disassembly (GO:0043624)3.35293781
95pseudouridine synthesis (GO:0001522)3.32364725
96sequestering of actin monomers (GO:0042989)3.31288723
97regulation of spindle checkpoint (GO:0090231)3.30382017
98regulation of retinoic acid receptor signaling pathway (GO:0048385)3.29912974
99regulation of microtubule-based movement (GO:0060632)3.28878909
100establishment of protein localization to mitochondrion (GO:0072655)3.28305901
101chaperone-mediated protein complex assembly (GO:0051131)3.28043173
102protein polyglutamylation (GO:0018095)3.27868988
103mitotic recombination (GO:0006312)3.24082045
104transcription from mitochondrial promoter (GO:0006390)3.23573384
105rRNA methylation (GO:0031167)3.22881545
106protein localization to mitochondrion (GO:0070585)3.21873389
107purine nucleobase biosynthetic process (GO:0009113)3.21778777
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21028830
109establishment of integrated proviral latency (GO:0075713)3.19337589
110nucleobase-containing small molecule interconversion (GO:0015949)3.18934893
111formation of translation preinitiation complex (GO:0001731)3.18867882
112rRNA metabolic process (GO:0016072)3.17710189
113glycerol ether metabolic process (GO:0006662)3.16846668
114protein localization to chromosome, centromeric region (GO:0071459)3.13484080
115inner mitochondrial membrane organization (GO:0007007)3.13242434
116protein deneddylation (GO:0000338)3.12921461
117peptidyl-histidine modification (GO:0018202)3.12839090
118calcium ion-dependent exocytosis (GO:0017156)3.12663414
119CENP-A containing nucleosome assembly (GO:0034080)3.11597486
120telomere maintenance via telomere lengthening (GO:0010833)3.08481882
121multicellular organismal reproductive process (GO:0048609)3.07419081
122mitochondrial fusion (GO:0008053)3.06785469
123regulation of translational fidelity (GO:0006450)3.06178837
124spliceosomal snRNP assembly (GO:0000387)3.05779327
125mitochondrial respiratory chain complex assembly (GO:0033108)3.03447531
126chromatin remodeling at centromere (GO:0031055)3.00894571
127positive regulation of ligase activity (GO:0051351)2.99291621
128mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97407617
129negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97286179
130guanosine-containing compound biosynthetic process (GO:1901070)2.96630884
131regulation of double-strand break repair via homologous recombination (GO:0010569)2.95512795
132protein complex disassembly (GO:0043241)2.95150469
133mitochondrial RNA metabolic process (GO:0000959)2.92530097
134transcription-coupled nucleotide-excision repair (GO:0006283)2.91528013
135nucleobase biosynthetic process (GO:0046112)2.90265896
136protein refolding (GO:0042026)2.90224270
137mitochondrial respiratory chain complex I assembly (GO:0032981)2.88312845
138NADH dehydrogenase complex assembly (GO:0010257)2.88312845
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88312845
140cullin deneddylation (GO:0010388)2.86268998
141ether metabolic process (GO:0018904)2.86057777
142protein complex biogenesis (GO:0070271)2.85747969
143establishment of chromosome localization (GO:0051303)2.85561073
144nucleotide-excision repair, DNA gap filling (GO:0006297)2.85560865
145regulation of ligase activity (GO:0051340)2.85440187
146termination of RNA polymerase III transcription (GO:0006386)2.85005250
147transcription elongation from RNA polymerase III promoter (GO:0006385)2.85005250
148protoporphyrinogen IX biosynthetic process (GO:0006782)2.84747796
149macromolecular complex disassembly (GO:0032984)2.83792854
150meiotic cell cycle process (GO:1903046)2.78593216
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73488702
152protein K6-linked ubiquitination (GO:0085020)2.72948790
153polyamine biosynthetic process (GO:0006596)2.69497009
154anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67277728
155alditol metabolic process (GO:0019400)2.66577695
156protein complex localization (GO:0031503)2.61313816
157mitotic nuclear envelope disassembly (GO:0007077)2.60939146
158negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59177652
159cell recognition (GO:0008037)2.58308911
160positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57860335
161spermatid nucleus differentiation (GO:0007289)2.57374271
162proteasome assembly (GO:0043248)2.57245158
163polyol catabolic process (GO:0046174)2.55830876
164regulation of spindle organization (GO:0090224)2.55003279
165ribosome assembly (GO:0042255)2.54047699
166nucleoside diphosphate phosphorylation (GO:0006165)2.53993781
167metaphase plate congression (GO:0051310)2.53263158
168L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52438806
169left/right pattern formation (GO:0060972)2.51134255
170regulation of centriole replication (GO:0046599)2.51039190
171cell redox homeostasis (GO:0045454)2.49446926
172microtubule polymerization or depolymerization (GO:0031109)2.49242756
173intraciliary transport (GO:0042073)2.48644609
174negative regulation of ligase activity (GO:0051352)2.47723362
175negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.47723362
176rRNA modification (GO:0000154)2.46943315
177ribosome biogenesis (GO:0042254)2.46777873
178membrane disassembly (GO:0030397)2.44331310
179nuclear envelope disassembly (GO:0051081)2.44331310
180regulation of chromosome segregation (GO:0051983)2.43528062
181histone exchange (GO:0043486)2.43405269
182positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.42262917
183regulation of ubiquitin-protein transferase activity (GO:0051438)2.39766074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.49143075
2* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10424913
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.95272512
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90439378
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.80049760
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.70357863
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70028624
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65627218
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.63306847
10* EST1_17652178_ChIP-ChIP_JURKAT_Human2.62549349
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58355359
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57949162
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.56500640
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32738282
15ZNF263_19887448_ChIP-Seq_K562_Human2.30167757
16E2F7_22180533_ChIP-Seq_HELA_Human2.24076984
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.08686194
18* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.07483764
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95270306
20GABP_19822575_ChIP-Seq_HepG2_Human1.79998836
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78622281
22VDR_23849224_ChIP-Seq_CD4+_Human1.71843992
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.70445164
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70386082
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69143796
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67976120
27DCP1A_22483619_ChIP-Seq_HELA_Human1.67673929
28* E2F1_21310950_ChIP-Seq_MCF-7_Human1.66018910
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.61001578
30XRN2_22483619_ChIP-Seq_HELA_Human1.58863508
31* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.57565624
32* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55392252
33* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51894884
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49398323
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.49008435
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48510107
37YY1_22570637_ChIP-Seq_MALME-3M_Human1.48270647
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48082216
39* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47813048
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47700380
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47181400
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46504301
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46445317
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46378833
45* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46317978
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45167719
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.44243890
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41103456
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39952701
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36665244
51* SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33422202
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31693521
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31567750
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26753595
55* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26135108
56GATA3_21867929_ChIP-Seq_CD8_Mouse1.25572402
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25308155
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.24571090
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24524342
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23570919
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22042240
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20505617
63AR_21909140_ChIP-Seq_LNCAP_Human1.17488779
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17424406
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.15836475
66SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15800910
67SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15481252
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14151578
69* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14042142
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13468795
71TFEB_21752829_ChIP-Seq_HELA_Human1.12557293
72FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12502808
73* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11143826
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10862986
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10732984
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10460469
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10115938
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09701953
79TTF2_22483619_ChIP-Seq_HELA_Human1.08931217
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07969559
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07885687
82KDM5A_27292631_Chip-Seq_BREAST_Human1.07586013
83FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06460562
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06218193
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05916872
86TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.05241356
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04760570
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04503270
89GATA1_26923725_Chip-Seq_HPCs_Mouse1.04485089
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04203951
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03393857
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03189235
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02850584
94RARA_24833708_ChIP-Seq_LIVER_Mouse1.02765267
95PHF8_20622854_ChIP-Seq_HELA_Human1.01589156
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00597745
97BCOR_27268052_Chip-Seq_Bcells_Human1.00493963
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00192784
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99299024
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.99296840
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98907841
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98701105
103ELK1_19687146_ChIP-ChIP_HELA_Human0.97596764
104* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97300704
105* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96835941
106CIITA_25753668_ChIP-Seq_RAJI_Human0.96733983
107* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96722506
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96285712
109* FOXP1_21924763_ChIP-Seq_HESCs_Human0.95684105
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95410689
111CTCF_26484167_Chip-Seq_Bcells_Mouse0.95320858
112VDR_21846776_ChIP-Seq_THP-1_Human0.94980134
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94888363
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94556553
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93889922
116MYC_18940864_ChIP-ChIP_HL60_Human0.93336391
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93205602
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92553064
119BCL6_27268052_Chip-Seq_Bcells_Human0.92342641
120CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92224672
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92016241
122LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91880149
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.91786376
124STAT1_17558387_ChIP-Seq_HELA_Human0.91114050
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90978035
126EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90687021
127TP63_19390658_ChIP-ChIP_HaCaT_Human0.90506583
128RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90491998
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88725515
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87813972
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84844385
132ELK1_22589737_ChIP-Seq_MCF10A_Human0.84765275
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84614471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.86670294
2MP0008877_abnormal_DNA_methylation4.86895902
3MP0001929_abnormal_gametogenesis4.25597230
4MP0003698_abnormal_male_reproductive3.96605034
5MP0003693_abnormal_embryo_hatching3.86495433
6MP0010030_abnormal_orbit_morphology3.54781676
7MP0002653_abnormal_ependyma_morphology3.05811944
8MP0002210_abnormal_sex_determination2.96240065
9MP0003646_muscle_fatigue2.88953428
10MP0006292_abnormal_olfactory_placode2.83314733
11MP0002161_abnormal_fertility/fecundity2.47156191
12MP0001145_abnormal_male_reproductive2.42612246
13MP0004957_abnormal_blastocyst_morpholog2.40650773
14MP0003111_abnormal_nucleus_morphology2.40415227
15MP0003077_abnormal_cell_cycle2.36528159
16MP0005670_abnormal_white_adipose2.35415169
17MP0010094_abnormal_chromosome_stability2.32517717
18MP0009379_abnormal_foot_pigmentation2.32069710
19MP0008058_abnormal_DNA_repair2.28222621
20MP0003718_maternal_effect2.24056679
21MP0009840_abnormal_foam_cell2.20592886
22MP0000653_abnormal_sex_gland2.20589850
23MP0000678_abnormal_parathyroid_gland1.91087927
24MP0003123_paternal_imprinting1.78040359
25MP0009333_abnormal_splenocyte_physiolog1.77978871
26MP0008007_abnormal_cellular_replicative1.77024510
27MP0000049_abnormal_middle_ear1.76221567
28MP0003221_abnormal_cardiomyocyte_apopto1.70681447
29MP0001346_abnormal_lacrimal_gland1.68552629
30MP0003806_abnormal_nucleotide_metabolis1.63528865
31MP0001529_abnormal_vocalization1.60954411
32MP0001986_abnormal_taste_sensitivity1.60860583
33MP0001730_embryonic_growth_arrest1.59075701
34MP0000358_abnormal_cell_content/1.57736377
35MP0006036_abnormal_mitochondrial_physio1.56280520
36MP0009053_abnormal_anal_canal1.52700909
37MP0003786_premature_aging1.45008005
38MP0010307_abnormal_tumor_latency1.44298393
39MP0001293_anophthalmia1.41305920
40MP0002132_abnormal_respiratory_system1.40637209
41MP0005501_abnormal_skin_physiology1.37756511
42MP0002160_abnormal_reproductive_system1.37593309
43MP0005623_abnormal_meninges_morphology1.36511960
44MP0005058_abnormal_lysosome_morphology1.36502934
45MP0001545_abnormal_hematopoietic_system1.35391067
46MP0005397_hematopoietic_system_phenotyp1.35391067
47MP0000647_abnormal_sebaceous_gland1.31084053
48MP0000537_abnormal_urethra_morphology1.30885652
49MP0005451_abnormal_body_composition1.28299050
50MP0004233_abnormal_muscle_weight1.21960334
51MP0005389_reproductive_system_phenotype1.17325100
52MP0008789_abnormal_olfactory_epithelium1.16702853
53MP0008932_abnormal_embryonic_tissue1.15813774
54MP0001764_abnormal_homeostasis1.15313506
55MP0008260_abnormal_autophagy1.14442935
56MP0004147_increased_porphyrin_level1.13637620
57MP0008057_abnormal_DNA_replication1.13094692
58MP0005636_abnormal_mineral_homeostasis1.11251419
59MP0002092_abnormal_eye_morphology1.09956682
60MP0002796_impaired_skin_barrier1.09722654
61MP0000750_abnormal_muscle_regeneration1.08778060
62MP0002163_abnormal_gland_morphology1.07075377
63MP0004043_abnormal_pH_regulation1.06814587
64MP0006035_abnormal_mitochondrial_morpho1.05826996
65MP0002249_abnormal_larynx_morphology1.05518203
66MP0000490_abnormal_crypts_of1.03765459
67MP0002697_abnormal_eye_size1.02950382
68MP0002877_abnormal_melanocyte_morpholog1.01588733
69MP0000313_abnormal_cell_death0.99641347
70MP0003942_abnormal_urinary_system0.99555738
71MP0001286_abnormal_eye_development0.99366205
72MP0003938_abnormal_ear_development0.99110160
73MP0001881_abnormal_mammary_gland0.96503181
74MP0002269_muscular_atrophy0.96170543
75MP0001672_abnormal_embryogenesis/_devel0.95973890
76MP0005380_embryogenesis_phenotype0.95973890
77MP0002080_prenatal_lethality0.94995060
78MP0005365_abnormal_bile_salt0.92686956
79MP0003315_abnormal_perineum_morphology0.92177944
80MP0004084_abnormal_cardiac_muscle0.92164500
81MP0003699_abnormal_female_reproductive0.91544269
82MP0005083_abnormal_biliary_tract0.90788699
83MP0000350_abnormal_cell_proliferation0.90490852
84MP0009278_abnormal_bone_marrow0.88507498
85MP0004019_abnormal_vitamin_homeostasis0.87798182
86MP0005394_taste/olfaction_phenotype0.87529753
87MP0005499_abnormal_olfactory_system0.87529753
88MP0002086_abnormal_extraembryonic_tissu0.86956631
89MP0005332_abnormal_amino_acid0.85404431
90MP0001697_abnormal_embryo_size0.85356430
91MP0001119_abnormal_female_reproductive0.82741031
92MP0005197_abnormal_uvea_morphology0.82414968
93MP0001765_abnormal_ion_homeostasis0.82390535
94MP0003186_abnormal_redox_activity0.82215363
95MP0003984_embryonic_growth_retardation0.82006915
96MP0003937_abnormal_limbs/digits/tail_de0.80678139
97MP0005076_abnormal_cell_differentiation0.80436391
98MP0002088_abnormal_embryonic_growth/wei0.80071904
99MP0000516_abnormal_urinary_system0.79807214
100MP0005367_renal/urinary_system_phenotyp0.79807214
101MP0004808_abnormal_hematopoietic_stem0.79667312
102MP0003755_abnormal_palate_morphology0.78889358
103MP0002139_abnormal_hepatobiliary_system0.78651419
104MP0003656_abnormal_erythrocyte_physiolo0.78194533
105MP0002111_abnormal_tail_morphology0.77379948
106MP0002233_abnormal_nose_morphology0.77332029
107MP0005319_abnormal_enzyme/_coenzyme0.76809180
108MP0002177_abnormal_outer_ear0.74745661
109MP0004197_abnormal_fetal_growth/weight/0.73598745
110MP0002277_abnormal_respiratory_mucosa0.73101324
111MP0004036_abnormal_muscle_relaxation0.72634773
112MP0005330_cardiomyopathy0.71116354
113MP0009672_abnormal_birth_weight0.70072786
114MP0003121_genomic_imprinting0.69858012
115MP0005408_hypopigmentation0.69811816
116MP0001919_abnormal_reproductive_system0.69312819
117MP0000013_abnormal_adipose_tissue0.68944576
118MP0002282_abnormal_trachea_morphology0.67322535
119MP0002098_abnormal_vibrissa_morphology0.66660381
120MP0008875_abnormal_xenobiotic_pharmacok0.66549418
121MP0000598_abnormal_liver_morphology0.66548347
122MP0003172_abnormal_lysosome_physiology0.66226556
123MP0009643_abnormal_urine_homeostasis0.64552530
124MP0002019_abnormal_tumor_incidence0.64541046
125MP0002938_white_spotting0.64528786
126MP0001756_abnormal_urination0.64242585
127MP0004185_abnormal_adipocyte_glucose0.63901998
128MP0005384_cellular_phenotype0.63704653
129MP0002060_abnormal_skin_morphology0.62433442
130MP0005395_other_phenotype0.61272946
131MP0002085_abnormal_embryonic_tissue0.58010923
132MP0002084_abnormal_developmental_patter0.57483720
133MP0002693_abnormal_pancreas_physiology0.57373536
134MP0008469_abnormal_protein_level0.53915104
135MP0009115_abnormal_fat_cell0.53165149
136MP0005257_abnormal_intraocular_pressure0.52504687
137MP0005621_abnormal_cell_physiology0.49215115
138MP0002970_abnormal_white_adipose0.49033752
139MP0000609_abnormal_liver_physiology0.48945023
140MP0000343_altered_response_to0.47897545
141MP0002078_abnormal_glucose_homeostasis0.46660291
142MP0005666_abnormal_adipose_tissue0.46517464
143MP0000689_abnormal_spleen_morphology0.44051800
144MP0001661_extended_life_span0.41882038
145MP0000371_diluted_coat_color0.41525170
146MP0005647_abnormal_sex_gland0.41442669
147MP0004133_heterotaxia0.41297719

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.00502317
2Absent/shortened dynein arms (HP:0200106)8.46072379
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.46072379
4Abnormal respiratory epithelium morphology (HP:0012253)6.15089291
5Abnormal respiratory motile cilium morphology (HP:0005938)6.15089291
6Abnormal respiratory motile cilium physiology (HP:0012261)6.12086429
7Chronic bronchitis (HP:0004469)5.80855857
8Infertility (HP:0000789)5.68731004
9Rhinitis (HP:0012384)5.41132482
10Nasal polyposis (HP:0100582)4.88940703
11Abnormal ciliary motility (HP:0012262)4.47458005
12Abnormal mitochondria in muscle tissue (HP:0008316)4.45004086
13Acute necrotizing encephalopathy (HP:0006965)4.29321600
14Impulsivity (HP:0100710)4.17332761
15Abnormality of the nasal mucosa (HP:0000433)4.04206007
16Reticulocytopenia (HP:0001896)3.98440306
17Male infertility (HP:0003251)3.93788076
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.89113239
19Acute encephalopathy (HP:0006846)3.83628375
20Degeneration of anterior horn cells (HP:0002398)3.79953207
21Abnormality of the anterior horn cell (HP:0006802)3.79953207
22Microvesicular hepatic steatosis (HP:0001414)3.64820713
23Mitochondrial inheritance (HP:0001427)3.49490933
24Abnormal umbilical cord blood vessels (HP:0011403)3.44300170
25Single umbilical artery (HP:0001195)3.44300170
26Abnormality of the fetal cardiovascular system (HP:0010948)3.44300170
27Bronchitis (HP:0012387)3.31775202
28Increased CSF lactate (HP:0002490)3.31549987
29Bronchiectasis (HP:0002110)3.26230138
30Increased intramyocellular lipid droplets (HP:0012240)3.21477518
31Macrocytic anemia (HP:0001972)3.18432782
32Progressive macrocephaly (HP:0004481)3.09856693
33Nephronophthisis (HP:0000090)3.04599436
34Hepatocellular necrosis (HP:0001404)3.03950017
35Abnormal number of incisors (HP:0011064)2.96000588
36Abnormal spermatogenesis (HP:0008669)2.90751835
37Abnormality of the umbilical cord (HP:0010881)2.88753594
38Increased hepatocellular lipid droplets (HP:0006565)2.84290785
39Gout (HP:0001997)2.82111100
40Cerebral edema (HP:0002181)2.81090426
41Increased serum pyruvate (HP:0003542)2.80283008
42Pallor (HP:0000980)2.76471264
43Cerebral hypomyelination (HP:0006808)2.76230078
44Birth length less than 3rd percentile (HP:0003561)2.75877087
45Microretrognathia (HP:0000308)2.75169106
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69286521
47Increased serum lactate (HP:0002151)2.68522094
48Increased muscle lipid content (HP:0009058)2.68126913
49Abnormality of glycolysis (HP:0004366)2.65053397
50Exercise intolerance (HP:0003546)2.62648602
51Abnormality of reticulocytes (HP:0004312)2.61559220
52Multiple enchondromatosis (HP:0005701)2.60950241
53Lipid accumulation in hepatocytes (HP:0006561)2.59980579
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.58663609
55Abnormality of the distal phalanges of the toes (HP:0010182)2.58433518
56Pancreatic fibrosis (HP:0100732)2.57182159
57Renal Fanconi syndrome (HP:0001994)2.52868302
58Breast hypoplasia (HP:0003187)2.52745939
59Lactic acidosis (HP:0003128)2.52298075
60Hepatic necrosis (HP:0002605)2.49648963
61Gonadotropin excess (HP:0000837)2.48367772
62Premature ovarian failure (HP:0008209)2.45930748
63Meckel diverticulum (HP:0002245)2.44275325
64Broad distal phalanx of finger (HP:0009836)2.42147995
65Type I transferrin isoform profile (HP:0003642)2.41786038
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40424322
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40424322
68Truncus arteriosus (HP:0001660)2.40410935
69Secondary amenorrhea (HP:0000869)2.39991074
70Abnormality of the preputium (HP:0100587)2.35520618
71Medial flaring of the eyebrow (HP:0010747)2.35158360
72Carpal bone hypoplasia (HP:0001498)2.34978783
73Ragged-red muscle fibers (HP:0003200)2.34787867
74Trismus (HP:0000211)2.32040725
75Abnormality of the ileum (HP:0001549)2.30839782
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30629308
77Selective tooth agenesis (HP:0001592)2.27670488
78Hypertensive crisis (HP:0100735)2.26968468
79Respiratory difficulties (HP:0002880)2.25636604
80Abnormal protein N-linked glycosylation (HP:0012347)2.25555329
81Abnormal protein glycosylation (HP:0012346)2.25555329
82Abnormal glycosylation (HP:0012345)2.25555329
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25555329
84Tongue fasciculations (HP:0001308)2.25483466
85Personality changes (HP:0000751)2.21902895
86Recurrent otitis media (HP:0000403)2.20776517
87Chromsome breakage (HP:0040012)2.20341848
88Constricted visual fields (HP:0001133)2.20228362
89Unsteady gait (HP:0002317)2.18199649
90Absent thumb (HP:0009777)2.16493230
91Respiratory failure (HP:0002878)2.15861687
92Abnormalities of placenta or umbilical cord (HP:0001194)2.15138872
93Muscle fibrillation (HP:0010546)2.13501077
94Sparse eyelashes (HP:0000653)2.12883111
95Abnormality of midbrain morphology (HP:0002418)2.11276304
96Molar tooth sign on MRI (HP:0002419)2.11276304
97Horseshoe kidney (HP:0000085)2.09188222
98Methylmalonic aciduria (HP:0012120)2.06378514
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.06204766
100Reduced antithrombin III activity (HP:0001976)2.05128626
101Hypoplasia of the radius (HP:0002984)2.04808835
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.02097548
103Absent epiphyses (HP:0010577)2.02097548
104Short thumb (HP:0009778)2.01678719
105Abnormality of the renal medulla (HP:0100957)2.01124230
106Rhabdomyolysis (HP:0003201)2.00229402
107Generalized aminoaciduria (HP:0002909)1.99747374
108Delusions (HP:0000746)1.99513169
109Hypoparathyroidism (HP:0000829)1.98875151
110Postnatal microcephaly (HP:0005484)1.97907654
111Proximal placement of thumb (HP:0009623)1.97104932
112Abnormal hemoglobin (HP:0011902)1.96809111
113Reticulocytosis (HP:0001923)1.96720810
114Absent radius (HP:0003974)1.95942026
115Exertional dyspnea (HP:0002875)1.93629015
116Spinal muscular atrophy (HP:0007269)1.92897700
117Recurrent sinusitis (HP:0011108)1.92200340
118Hyperthyroidism (HP:0000836)1.90338940
119Abnormal lung lobation (HP:0002101)1.89576143
120Global brain atrophy (HP:0002283)1.89060465
121Cholecystitis (HP:0001082)1.88285661
122Abnormal gallbladder physiology (HP:0012438)1.88285661
123Absent forearm bone (HP:0003953)1.86863828
124Aplasia involving forearm bones (HP:0009822)1.86863828
125Myoglobinuria (HP:0002913)1.85384219
126Insulin-resistant diabetes mellitus (HP:0000831)1.84816937
127Glucose intolerance (HP:0000833)1.84802361
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.84001120
129Nausea (HP:0002018)1.83606926
130Pancytopenia (HP:0001876)1.83574836
131Leukodystrophy (HP:0002415)1.82412754
132Abnormality of chromosome stability (HP:0003220)1.81647419
133Asymmetric septal hypertrophy (HP:0001670)1.80624654
134Hypoplastic pelvis (HP:0008839)1.79126625
135Pancreatic cysts (HP:0001737)1.78937217
136Septate vagina (HP:0001153)1.77277358
137Cortical dysplasia (HP:0002539)1.77033402
138Spastic paraparesis (HP:0002313)1.76001420
139Deviation of the thumb (HP:0009603)1.75450229
140Glossoptosis (HP:0000162)1.73801543
141Small intestinal stenosis (HP:0012848)1.72953339
142Hypoglycemic seizures (HP:0002173)1.69004078
143Oculomotor apraxia (HP:0000657)1.67488163
144Upper motor neuron abnormality (HP:0002127)1.67075834
145Recurrent bronchitis (HP:0002837)1.65721432
146Difficulty climbing stairs (HP:0003551)1.64097968
147Hyperglycinemia (HP:0002154)1.63556276
148Supernumerary spleens (HP:0009799)1.63542445
149CNS hypomyelination (HP:0003429)1.63279094
150Facial cleft (HP:0002006)1.61042915
151Abnormality of aromatic amino acid family metabolism (HP:0004338)1.59132492
152Poor coordination (HP:0002370)1.58338661
153Oligomenorrhea (HP:0000876)1.58213943
154Congenital primary aphakia (HP:0007707)1.58112691
155Short nail (HP:0001799)1.57384217
156Sloping forehead (HP:0000340)1.57369799
157Neurodegeneration (HP:0002180)1.57090142
158True hermaphroditism (HP:0010459)1.57050211
159Progressive muscle weakness (HP:0003323)1.56610051
160Rough bone trabeculation (HP:0100670)1.56457178
161Cleft eyelid (HP:0000625)1.56164164
162Abnormal number of erythroid precursors (HP:0012131)1.55857423
163Azoospermia (HP:0000027)1.53388062
164Bundle branch block (HP:0011710)1.51968656
165Polydipsia (HP:0001959)1.51831889
166Abnormal drinking behavior (HP:0030082)1.51831889
167Areflexia of lower limbs (HP:0002522)1.51359521
168Late onset (HP:0003584)1.50730265
169Cerebellar dysplasia (HP:0007033)1.50604530
170Insulin resistance (HP:0000855)1.50457372
171Abnormality of the lower motor neuron (HP:0002366)1.50444144
172Flat capital femoral epiphysis (HP:0003370)1.49660656
173Aplasia/Hypoplasia of the uvula (HP:0010293)1.48734333
174Abnormal neuron morphology (HP:0012757)1.48545758
175Abnormality of the motor neurons (HP:0002450)1.48545758
176Double outlet right ventricle (HP:0001719)1.48028402
177Congenital malformation of the right heart (HP:0011723)1.48028402
178Poor suck (HP:0002033)1.47992484
179Tubular atrophy (HP:0000092)1.45769010
180Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.45274479
181Hyperglycemia (HP:0003074)1.44066218
182Abnormality of cells of the erythroid lineage (HP:0012130)1.43722232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.71307322
2PDK36.71307322
3TESK14.23715968
4PDK24.23289994
5BUB13.52558744
6PRKD32.87323233
7EIF2AK12.84543486
8VRK22.83643808
9TRIM282.83091524
10TESK22.49265303
11WEE12.41745555
12PLK42.36926776
13NEK21.89228412
14TTK1.74267692
15NME21.72070057
16CCNB11.71266638
17BRSK21.59669280
18BCKDK1.51611887
19BRAF1.47478139
20TLK11.41592212
21TAOK21.41552629
22ZAK1.38770279
23STK38L1.37700904
24SMG11.29503118
25ARAF1.27469379
26PASK1.22513752
27PLK11.22441437
28CDC71.19795922
29STK161.16041487
30MAP3K31.14476137
31AKT31.14222757
32PINK11.09389221
33STK101.07531984
34CHEK21.07162083
35NEK11.06965983
36STK41.05090448
37LATS21.04492583
38TSSK61.02790899
39BRSK11.02597197
40EIF2AK31.02368892
41ICK1.02251533
42ABL20.98371953
43PTK2B0.97199076
44SIK30.94454587
45EEF2K0.93499080
46MOS0.91891970
47MAPK150.89945248
48CLK10.88911581
49PRPF4B0.87615516
50GRK70.86496239
51AURKA0.85854029
52MAPKAPK30.83025693
53MAP3K120.82893045
54DYRK1B0.81788883
55IRAK30.81049755
56WNK40.79786614
57RPS6KA40.78605063
58ADRBK20.77786058
59ATR0.76590180
60PRKCI0.76188698
61STK30.75533498
62ZAP700.74270964
63RPS6KA50.73440006
64TAF10.70715013
65IRAK20.70704349
66PAK10.69629496
67DYRK30.69226932
68PDK10.68915907
69ERBB40.66845745
70LRRK20.66232866
71AKT20.64915759
72MAP2K30.62544467
73SRPK10.62385189
74MAP3K80.62376740
75KSR20.61481576
76AURKB0.61181163
77KSR10.60364676
78CDK70.60242918
79ILK0.60082472
80MST1R0.59430162
81EPHB20.59122757
82PLK30.58850296
83LIMK10.58546361
84PIM10.57626510
85IRAK40.57546396
86PBK0.57543154
87MAP4K20.56635665
88CDK40.56536261
89MST40.55787125
90CHEK10.55764086
91BMX0.55305816
92MARK30.54737252
93CDK150.54149471
94MAP3K60.53659859
95DYRK20.52974853
96FLT30.52793198
97TRPM70.52225601
98CDK180.52161123
99TYRO30.51327880
100CDK140.49993937
101STK380.49086323
102DMPK0.47143594
103CDK10.45073818
104EIF2AK20.44850850
105CSNK1G30.44639437
106PAK40.42816166
107NUAK10.42350336
108VRK10.42042639
109KIT0.41271183
110PIM20.40995730
111ERN10.40813027
112SCYL20.40357348
113DAPK10.38321218
114CSNK2A10.36145870
115PAK60.34509734
116TRIB30.33560734
117ACVR1B0.33546987
118PNCK0.32924080
119ADRBK10.32123501
120MAP4K10.29874084
121RPS6KB20.28935234
122MAP2K60.27932841
123PDPK10.27665905
124ATM0.27626444
125NME10.26945259
126IRAK10.26534839
127CDK80.26082559
128CSNK2A20.25991408
129MAP2K70.23433093
130CDK20.23271974
131TAOK10.22473081
132PRKCG0.22080362
133CDK11A0.20616239
134MAP3K50.20402534
135MAP3K110.19808220
136RAF10.19571617
137CAMKK20.18692229
138PRKG20.18567808
139TBK10.17857275
140EPHA20.17278762
141KDR0.16944342

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.04871466
2Proteasome_Homo sapiens_hsa030503.19878319
3DNA replication_Homo sapiens_hsa030302.90372630
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.74779120
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66146524
6Basal transcription factors_Homo sapiens_hsa030222.49294303
7RNA polymerase_Homo sapiens_hsa030202.44179378
8RNA transport_Homo sapiens_hsa030132.42949199
9Pyruvate metabolism_Homo sapiens_hsa006202.39655662
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37804644
11Mismatch repair_Homo sapiens_hsa034302.15350951
12Pyrimidine metabolism_Homo sapiens_hsa002402.10839441
13Pentose phosphate pathway_Homo sapiens_hsa000301.97616416
14Folate biosynthesis_Homo sapiens_hsa007901.93604422
15Base excision repair_Homo sapiens_hsa034101.89835842
16Cell cycle_Homo sapiens_hsa041101.87885435
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.87729922
18Selenocompound metabolism_Homo sapiens_hsa004501.87200209
19Nucleotide excision repair_Homo sapiens_hsa034201.85878802
20Carbon metabolism_Homo sapiens_hsa012001.83222167
21Biosynthesis of amino acids_Homo sapiens_hsa012301.78551750
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.78322204
23Propanoate metabolism_Homo sapiens_hsa006401.71985441
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59953856
25Fructose and mannose metabolism_Homo sapiens_hsa000511.58541201
26Purine metabolism_Homo sapiens_hsa002301.57095875
27Spliceosome_Homo sapiens_hsa030401.53528583
28Linoleic acid metabolism_Homo sapiens_hsa005911.51551226
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.49339106
30Fanconi anemia pathway_Homo sapiens_hsa034601.49118683
31Steroid biosynthesis_Homo sapiens_hsa001001.44900998
32Homologous recombination_Homo sapiens_hsa034401.43932534
33Alzheimers disease_Homo sapiens_hsa050101.42763069
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41068998
35Collecting duct acid secretion_Homo sapiens_hsa049661.40537203
36Regulation of autophagy_Homo sapiens_hsa041401.37353918
37Fatty acid elongation_Homo sapiens_hsa000621.35551108
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34536775
39Oocyte meiosis_Homo sapiens_hsa041141.33656634
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32442987
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.28795376
42Sulfur relay system_Homo sapiens_hsa041221.26955539
43One carbon pool by folate_Homo sapiens_hsa006701.21452349
44Huntingtons disease_Homo sapiens_hsa050161.20925368
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16466753
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.16065727
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15039611
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14765572
49Legionellosis_Homo sapiens_hsa051341.12441995
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11880896
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.10015985
52Glucagon signaling pathway_Homo sapiens_hsa049221.08449243
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05634892
54Antigen processing and presentation_Homo sapiens_hsa046121.04616978
55Ribosome_Homo sapiens_hsa030101.01432020
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99904165
57Fatty acid degradation_Homo sapiens_hsa000710.99467854
58Protein export_Homo sapiens_hsa030600.96806661
59RNA degradation_Homo sapiens_hsa030180.95131912
60Epstein-Barr virus infection_Homo sapiens_hsa051690.94864175
61p53 signaling pathway_Homo sapiens_hsa041150.94323335
62Non-homologous end-joining_Homo sapiens_hsa034500.92762553
63Oxidative phosphorylation_Homo sapiens_hsa001900.90462910
64Other glycan degradation_Homo sapiens_hsa005110.84346849
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83628872
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82361059
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79910573
68Glycerolipid metabolism_Homo sapiens_hsa005610.79149655
69mRNA surveillance pathway_Homo sapiens_hsa030150.77516046
70Metabolic pathways_Homo sapiens_hsa011000.76351281
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76070773
72Glutathione metabolism_Homo sapiens_hsa004800.73829637
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70273933
74Cardiac muscle contraction_Homo sapiens_hsa042600.67091325
75Lysosome_Homo sapiens_hsa041420.66721895
76Vibrio cholerae infection_Homo sapiens_hsa051100.66515515
77Galactose metabolism_Homo sapiens_hsa000520.61134581
78Parkinsons disease_Homo sapiens_hsa050120.60344006
79Fatty acid biosynthesis_Homo sapiens_hsa000610.58585632
80Bladder cancer_Homo sapiens_hsa052190.58487020
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.57770774
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55022910
83Arachidonic acid metabolism_Homo sapiens_hsa005900.54005761
84Fatty acid metabolism_Homo sapiens_hsa012120.53300263
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52561690
86Phenylalanine metabolism_Homo sapiens_hsa003600.52458962
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51046741
88Phagosome_Homo sapiens_hsa041450.50480228
89Synaptic vesicle cycle_Homo sapiens_hsa047210.48874187
90Mineral absorption_Homo sapiens_hsa049780.45351404
91Sulfur metabolism_Homo sapiens_hsa009200.45224517
92Renin-angiotensin system_Homo sapiens_hsa046140.42886139
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42885467
94PPAR signaling pathway_Homo sapiens_hsa033200.42772406
95beta-Alanine metabolism_Homo sapiens_hsa004100.42733187
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41580119
97Systemic lupus erythematosus_Homo sapiens_hsa053220.40605814
98Peroxisome_Homo sapiens_hsa041460.40319496
99Hedgehog signaling pathway_Homo sapiens_hsa043400.36347127
100Fat digestion and absorption_Homo sapiens_hsa049750.36149014
101Apoptosis_Homo sapiens_hsa042100.35251165
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.35127374
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35057565
104Vitamin digestion and absorption_Homo sapiens_hsa049770.33843556
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32513838
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31958704
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31559755
108N-Glycan biosynthesis_Homo sapiens_hsa005100.31337222
109Alcoholism_Homo sapiens_hsa050340.31321070
110Tyrosine metabolism_Homo sapiens_hsa003500.29824468
111Arginine and proline metabolism_Homo sapiens_hsa003300.29559802
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27911683
113Basal cell carcinoma_Homo sapiens_hsa052170.27173665
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.27033161
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26237807
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25918338
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25825019
118Viral carcinogenesis_Homo sapiens_hsa052030.24171204
119Shigellosis_Homo sapiens_hsa051310.23436628
120Ether lipid metabolism_Homo sapiens_hsa005650.23193758
121Rheumatoid arthritis_Homo sapiens_hsa053230.22713372
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22195374
123HTLV-I infection_Homo sapiens_hsa051660.22001120
124Thyroid cancer_Homo sapiens_hsa052160.18192586
125Herpes simplex infection_Homo sapiens_hsa051680.18157534
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17410886
127TGF-beta signaling pathway_Homo sapiens_hsa043500.13953955
128Hepatitis B_Homo sapiens_hsa051610.11376023
129MicroRNAs in cancer_Homo sapiens_hsa052060.10009911
130Hippo signaling pathway_Homo sapiens_hsa043900.09938291
131Small cell lung cancer_Homo sapiens_hsa052220.05341707
132HIF-1 signaling pathway_Homo sapiens_hsa040660.05202859
133Prion diseases_Homo sapiens_hsa050200.04893149

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