FLAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.82395088
2L-phenylalanine catabolic process (GO:0006559)5.82395088
3L-phenylalanine metabolic process (GO:0006558)5.70693976
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.70693976
5lysine catabolic process (GO:0006554)5.01873953
6lysine metabolic process (GO:0006553)5.01873953
7aromatic amino acid family catabolic process (GO:0009074)5.00381856
8glyoxylate metabolic process (GO:0046487)4.74773123
9proteasome assembly (GO:0043248)4.73948938
10fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.73099012
11alpha-linolenic acid metabolic process (GO:0036109)4.72991347
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.64356956
132-oxoglutarate metabolic process (GO:0006103)4.53657650
14pseudouridine synthesis (GO:0001522)4.51298527
15kynurenine metabolic process (GO:0070189)4.46715013
16bile acid biosynthetic process (GO:0006699)4.45179712
17fatty acid beta-oxidation (GO:0006635)4.37389177
18tricarboxylic acid cycle (GO:0006099)4.34805514
19chaperone-mediated protein transport (GO:0072321)4.32864635
20tryptophan catabolic process (GO:0006569)4.30011761
21indole-containing compound catabolic process (GO:0042436)4.30011761
22indolalkylamine catabolic process (GO:0046218)4.30011761
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.29933411
24amino-acid betaine metabolic process (GO:0006577)4.29489947
25rRNA modification (GO:0000154)4.29389744
26cysteine metabolic process (GO:0006534)4.26541246
27valine metabolic process (GO:0006573)4.23207661
28sulfur amino acid catabolic process (GO:0000098)4.13450970
29regulation of triglyceride catabolic process (GO:0010896)4.10333274
30fatty acid catabolic process (GO:0009062)4.08941723
31tryptophan metabolic process (GO:0006568)4.08882780
32serine family amino acid catabolic process (GO:0009071)4.04346605
33establishment of protein localization to mitochondrial membrane (GO:0090151)4.01889401
34fatty acid oxidation (GO:0019395)4.01420089
35aspartate family amino acid catabolic process (GO:0009068)3.99878101
36regulation of mitochondrial translation (GO:0070129)3.99779918
37acetyl-CoA metabolic process (GO:0006084)3.98461754
38oxaloacetate metabolic process (GO:0006107)3.98236663
39respiratory chain complex IV assembly (GO:0008535)3.97153173
40urea metabolic process (GO:0019627)3.95525672
41urea cycle (GO:0000050)3.95525672
42lipid oxidation (GO:0034440)3.92974798
43branched-chain amino acid catabolic process (GO:0009083)3.92598768
44NADH metabolic process (GO:0006734)3.91890321
45regulation of cellular amino acid metabolic process (GO:0006521)3.91668310
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.89863604
47tricarboxylic acid metabolic process (GO:0072350)3.89807294
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89323897
49negative regulation of ligase activity (GO:0051352)3.88013635
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.88013635
51cellular ketone body metabolic process (GO:0046950)3.86271934
52alpha-amino acid catabolic process (GO:1901606)3.84820250
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.83089239
54termination of RNA polymerase III transcription (GO:0006386)3.83089239
55monocarboxylic acid catabolic process (GO:0072329)3.81143541
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.78645855
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.78645855
58coenzyme catabolic process (GO:0009109)3.78455536
59cullin deneddylation (GO:0010388)3.77418379
60mitochondrial RNA metabolic process (GO:0000959)3.76811546
61short-chain fatty acid metabolic process (GO:0046459)3.75370119
62aromatic amino acid family metabolic process (GO:0009072)3.74533610
63carnitine metabolic process (GO:0009437)3.73979645
64ethanol oxidation (GO:0006069)3.73899043
65succinate metabolic process (GO:0006105)3.73136712
66glycine metabolic process (GO:0006544)3.72942205
67fatty acid transmembrane transport (GO:1902001)3.72731375
68branched-chain amino acid metabolic process (GO:0009081)3.71447975
69protein deneddylation (GO:0000338)3.70128367
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69491491
71DNA damage response, detection of DNA damage (GO:0042769)3.69417560
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67573389
73high-density lipoprotein particle remodeling (GO:0034375)3.67446013
74bile acid metabolic process (GO:0008206)3.65602329
75carnitine shuttle (GO:0006853)3.65372030
76cellular amino acid catabolic process (GO:0009063)3.65301991
77protein targeting to mitochondrion (GO:0006626)3.64780032
78nitrogen cycle metabolic process (GO:0071941)3.64418829
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64132704
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.62838369
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.62838369
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.62838369
83protein complex biogenesis (GO:0070271)3.62552745
84mitochondrial respiratory chain complex I assembly (GO:0032981)3.60158385
85NADH dehydrogenase complex assembly (GO:0010257)3.60158385
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60158385
87DNA strand elongation involved in DNA replication (GO:0006271)3.59355774
88mitochondrial respiratory chain complex assembly (GO:0033108)3.58930533
89base-excision repair, AP site formation (GO:0006285)3.57986902
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.57288688
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.57288688
92complement activation, alternative pathway (GO:0006957)3.56435115
93carboxylic acid catabolic process (GO:0046395)3.56403335
94organic acid catabolic process (GO:0016054)3.56403335
95rRNA methylation (GO:0031167)3.55454512
96signal transduction involved in DNA damage checkpoint (GO:0072422)3.51787856
97signal transduction involved in DNA integrity checkpoint (GO:0072401)3.51787856
98negative regulation of fibrinolysis (GO:0051918)3.51374639
99energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50554305
100ATP synthesis coupled proton transport (GO:0015986)3.50554305
101signal transduction involved in cell cycle checkpoint (GO:0072395)3.49632840
102serine family amino acid metabolic process (GO:0009069)3.49212257
103homocysteine metabolic process (GO:0050667)3.49144485
104regulation of protein activation cascade (GO:2000257)3.48339024
105acylglycerol homeostasis (GO:0055090)3.45830928
106triglyceride homeostasis (GO:0070328)3.45830928
107peptidyl-glutamic acid carboxylation (GO:0017187)3.45286855
108protein carboxylation (GO:0018214)3.45286855
109peptidyl-histidine modification (GO:0018202)3.44407403
110cytochrome complex assembly (GO:0017004)3.43801729
111spliceosomal snRNP assembly (GO:0000387)3.43048366
112establishment of protein localization to mitochondrion (GO:0072655)3.42698990
113DNA strand elongation (GO:0022616)3.40856137
114tyrosine metabolic process (GO:0006570)3.38479326
115GDP-mannose metabolic process (GO:0019673)3.37608349
116kinetochore assembly (GO:0051382)3.34354989
117serine family amino acid biosynthetic process (GO:0009070)3.33967009
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33745398
119telomere maintenance via semi-conservative replication (GO:0032201)3.33674302
120DNA deamination (GO:0045006)3.33076543
121ketone body metabolic process (GO:1902224)3.32672715
122iron-sulfur cluster assembly (GO:0016226)3.32350026
123metallo-sulfur cluster assembly (GO:0031163)3.32350026
124regulation of cholesterol esterification (GO:0010872)3.31069909
125tRNA processing (GO:0008033)3.31019399
126phospholipid efflux (GO:0033700)3.29873271
127cofactor catabolic process (GO:0051187)3.29720874
128protein localization to mitochondrion (GO:0070585)3.29411640
129NAD metabolic process (GO:0019674)3.29131989
130regulation of sequestering of triglyceride (GO:0010889)3.27178417
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.26429733
132tRNA modification (GO:0006400)3.25622713
133dicarboxylic acid biosynthetic process (GO:0043650)3.25232523
134regulation of complement activation (GO:0030449)3.23220699
135nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22100034
136regulation of fibrinolysis (GO:0051917)3.21537859
137plasma lipoprotein particle remodeling (GO:0034369)3.21250892
138protein-lipid complex remodeling (GO:0034368)3.21250892
139macromolecular complex remodeling (GO:0034367)3.21250892
140positive regulation of ligase activity (GO:0051351)3.19532534
141mannosylation (GO:0097502)3.19413016
142DNA replication checkpoint (GO:0000076)3.18304630
143tRNA metabolic process (GO:0006399)3.18227342
144cellular modified amino acid catabolic process (GO:0042219)3.18093860
145L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17924534
146mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.17774081
147glutamate metabolic process (GO:0006536)3.17609922
148exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17097171
149regulation of fatty acid oxidation (GO:0046320)3.16998223
150phospholipid homeostasis (GO:0055091)3.16961931
151somatic hypermutation of immunoglobulin genes (GO:0016446)3.16605725
152somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16605725
153L-serine metabolic process (GO:0006563)3.16452787
154positive regulation of fatty acid beta-oxidation (GO:0032000)3.15438227
155regulation of cholesterol metabolic process (GO:0090181)3.15311509
156indolalkylamine metabolic process (GO:0006586)3.15075121
157regulation of mitotic spindle checkpoint (GO:1903504)3.14863573
158regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14863573
159reverse cholesterol transport (GO:0043691)3.14778577
160ribosome biogenesis (GO:0042254)3.14339939
161rRNA processing (GO:0006364)3.13872005
162aldehyde catabolic process (GO:0046185)3.13679285
163fatty acid homeostasis (GO:0055089)3.13122801
164plasma lipoprotein particle clearance (GO:0034381)3.11976279
165thioester biosynthetic process (GO:0035384)3.11439665
166acyl-CoA biosynthetic process (GO:0071616)3.11439665
167transcription from mitochondrial promoter (GO:0006390)3.08357473
168DNA strand renaturation (GO:0000733)3.08237637
169oxidative phosphorylation (GO:0006119)3.08190271
170chromatin remodeling at centromere (GO:0031055)3.07281019
171negative regulation of sterol transport (GO:0032372)3.06729312
172negative regulation of cholesterol transport (GO:0032375)3.06729312
173biotin metabolic process (GO:0006768)3.05743636
174dicarboxylic acid metabolic process (GO:0043648)3.05416065
175pyrimidine nucleoside catabolic process (GO:0046135)3.05232912
176rRNA metabolic process (GO:0016072)3.03959230
177fructose metabolic process (GO:0006000)3.03740797
178DNA catabolic process, exonucleolytic (GO:0000738)3.03250232
179regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02566075
180deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.00874497
181maturation of 5.8S rRNA (GO:0000460)2.98861461
182protein-cofactor linkage (GO:0018065)2.98614308
183regulation of cellular amine metabolic process (GO:0033238)2.96627898
184ncRNA processing (GO:0034470)2.96533219
185regulation of ubiquitin-protein transferase activity (GO:0051438)2.96054494
186CENP-A containing nucleosome assembly (GO:0034080)2.95295463
187cellular component biogenesis (GO:0044085)2.95234731
188ncRNA metabolic process (GO:0034660)2.95120603
189inner mitochondrial membrane organization (GO:0007007)2.93377426
190DNA double-strand break processing (GO:0000729)2.92662358
191respiratory electron transport chain (GO:0022904)2.91721217
192tRNA methylation (GO:0030488)2.91261272
193amino acid activation (GO:0043038)2.91206541
194tRNA aminoacylation (GO:0043039)2.91206541
195DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.91184080
196ribosome assembly (GO:0042255)2.90977105
197electron transport chain (GO:0022900)2.89751372
198nucleobase biosynthetic process (GO:0046112)2.89254187
199regulation of ligase activity (GO:0051340)2.85728176
200pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85516897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.08903685
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.90305658
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.27263507
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.85751175
5E2F7_22180533_ChIP-Seq_HELA_Human4.13865768
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.97679265
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.75566485
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.75057203
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.68555654
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.14318374
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.95125601
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70702154
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68283000
14* XRN2_22483619_ChIP-Seq_HELA_Human2.65557852
15* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42014347
16GATA1_22025678_ChIP-Seq_K562_Human2.41325982
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37009946
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27648506
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23562570
20* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.15287001
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09785317
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09717192
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05289438
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03771093
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01651138
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.00982284
27* TTF2_22483619_ChIP-Seq_HELA_Human1.95665389
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92199577
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.91339735
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84835321
31* KDM5A_27292631_Chip-Seq_BREAST_Human1.77754573
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.75602741
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73667450
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.70905204
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.70003214
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69379752
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65002915
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64893979
39* GABP_17652178_ChIP-ChIP_JURKAT_Human1.62149760
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62035609
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59658897
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.55575571
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.55053502
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53307720
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52303254
46TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51448832
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50819335
48MYC_18940864_ChIP-ChIP_HL60_Human1.50763372
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44955319
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43548616
51* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43376691
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42743855
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.40835455
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.39961996
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39315404
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34899811
57* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34382351
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.34067566
59* E2F1_21310950_ChIP-Seq_MCF-7_Human1.32185759
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30622706
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29559394
62* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.28608226
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28062590
64ZNF263_19887448_ChIP-Seq_K562_Human1.26546846
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26511721
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23370964
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22355756
68FOXP1_21924763_ChIP-Seq_HESCs_Human1.22158119
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21802283
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21702661
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21684135
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19271400
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18413802
74DCP1A_22483619_ChIP-Seq_HELA_Human1.17611979
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15342372
76* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15001113
77FOXP3_21729870_ChIP-Seq_TREG_Human1.11929727
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11144348
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09660095
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09175443
81CLOCK_20551151_ChIP-Seq_293T_Human1.08597346
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08402785
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06595075
84ZNF274_21170338_ChIP-Seq_K562_Hela1.05312942
85VDR_23849224_ChIP-Seq_CD4+_Human1.05225086
86GABP_19822575_ChIP-Seq_HepG2_Human1.03429878
87BCL6_27268052_Chip-Seq_Bcells_Human1.03295074
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01579472
89* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99497976
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.99151413
91TET1_21451524_ChIP-Seq_MESCs_Mouse0.98946822
92BCOR_27268052_Chip-Seq_Bcells_Human0.97466579
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97250924
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96543421
95LXR_22292898_ChIP-Seq_THP-1_Human0.96528259
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96116132
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96044434
98RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95899305
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95572806
100CIITA_25753668_ChIP-Seq_RAJI_Human0.95139503
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93619566
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93012751
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.92472044
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91467111
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90561205
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90531912
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89044984
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88495194
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88416081
110* RARA_24833708_ChIP-Seq_LIVER_Mouse0.87830270
111E2F1_20622854_ChIP-Seq_HELA_Human0.87673765
112* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87665138
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87516299
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87362150
115YY1_22570637_ChIP-Seq_MALME-3M_Human0.87211547
116HTT_18923047_ChIP-ChIP_STHdh_Human0.86451474
117CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85821823
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85790211
119ELK1_22589737_ChIP-Seq_MCF10A_Human0.84775427
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83869736
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83657312
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83416109
123P68_20966046_ChIP-Seq_HELA_Human0.83288029
124* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83278751
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83072026
126HNF4A_19822575_ChIP-Seq_HepG2_Human0.82903881
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82748317
128* ERA_21632823_ChIP-Seq_H3396_Human0.81559753
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80545711
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.80449653
131* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80018613
132TFEB_21752829_ChIP-Seq_HELA_Human0.79180484
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.78942963
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78843792
135TP63_19390658_ChIP-ChIP_HaCaT_Human0.78567228
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78276553
137FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.78255255
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78029443
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.77527951
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77497386
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77033049
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.76548315
143SPI1_20517297_ChIP-Seq_HL60_Human0.76442709
144ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76325036
145MYC_19030024_ChIP-ChIP_MESCs_Mouse0.75441372
146VDR_21846776_ChIP-Seq_THP-1_Human0.75260662
147CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75108254
148RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74932782
149MYC_22102868_ChIP-Seq_BL_Human0.73939842
150PHF8_20622854_ChIP-Seq_HELA_Human0.73149762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.91047345
2MP0005360_urolithiasis5.41509080
3MP0005365_abnormal_bile_salt4.75558678
4MP0003806_abnormal_nucleotide_metabolis4.70281218
5MP0005085_abnormal_gallbladder_physiolo4.63656145
6MP0008058_abnormal_DNA_repair4.44294388
7MP0003693_abnormal_embryo_hatching4.04307273
8MP0010094_abnormal_chromosome_stability3.82639588
9MP0008875_abnormal_xenobiotic_pharmacok3.61716668
10MP0002837_dystrophic_cardiac_calcinosis3.46744021
11MP0003111_abnormal_nucleus_morphology3.41655165
12MP0004957_abnormal_blastocyst_morpholog2.99926275
13MP0009840_abnormal_foam_cell2.99057356
14MP0010329_abnormal_lipoprotein_level2.98189696
15MP0003077_abnormal_cell_cycle2.80930685
16MP0005083_abnormal_biliary_tract2.79403133
17MP0003646_muscle_fatigue2.72375118
18MP0003718_maternal_effect2.67613489
19MP0003195_calcinosis2.60138710
20MP0005332_abnormal_amino_acid2.52033210
21MP0006036_abnormal_mitochondrial_physio2.50693274
22MP0003252_abnormal_bile_duct2.49566757
23MP0003786_premature_aging2.46267818
24MP0005171_absent_coat_pigmentation2.28212109
25MP0008932_abnormal_embryonic_tissue2.26874843
26MP0004130_abnormal_muscle_cell2.25434840
27MP0008007_abnormal_cellular_replicative2.17900642
28MP0001666_abnormal_nutrient_absorption2.06874767
29MP0001764_abnormal_homeostasis2.05093244
30MP0000372_irregular_coat_pigmentation2.04005400
31MP0003191_abnormal_cellular_cholesterol2.03732549
32MP0005670_abnormal_white_adipose2.02190187
33MP0002118_abnormal_lipid_homeostasis1.96456185
34MP0001986_abnormal_taste_sensitivity1.96074738
35MP0000609_abnormal_liver_physiology1.95967681
36MP0005319_abnormal_enzyme/_coenzyme1.92639805
37MP0002736_abnormal_nociception_after1.91777822
38MP0002254_reproductive_system_inflammat1.90976656
39MP0008877_abnormal_DNA_methylation1.85783625
40MP0003136_yellow_coat_color1.85512648
41MP0002102_abnormal_ear_morphology1.84717952
42MP0001873_stomach_inflammation1.78339870
43MP0003656_abnormal_erythrocyte_physiolo1.75771815
44MP0001188_hyperpigmentation1.70712813
45MP0005584_abnormal_enzyme/coenzyme_acti1.70565320
46MP0004084_abnormal_cardiac_muscle1.70123332
47MP0004036_abnormal_muscle_relaxation1.62421597
48MP0005330_cardiomyopathy1.62243782
49MP0006035_abnormal_mitochondrial_morpho1.61722505
50MP0002160_abnormal_reproductive_system1.59589554
51MP0001968_abnormal_touch/_nociception1.53980094
52MP0005174_abnormal_tail_pigmentation1.51756734
53MP0009643_abnormal_urine_homeostasis1.51161420
54MP0000749_muscle_degeneration1.50601979
55MP0008789_abnormal_olfactory_epithelium1.50239387
56MP0002269_muscular_atrophy1.41025978
57MP0004019_abnormal_vitamin_homeostasis1.39619715
58MP0003186_abnormal_redox_activity1.39014495
59MP0004215_abnormal_myocardial_fiber1.35530591
60MP0005666_abnormal_adipose_tissue1.32233107
61MP0005253_abnormal_eye_physiology1.31242891
62MP0006292_abnormal_olfactory_placode1.31163062
63MP0001529_abnormal_vocalization1.29729488
64MP0002138_abnormal_hepatobiliary_system1.27030092
65MP0000751_myopathy1.26848128
66MP0002638_abnormal_pupillary_reflex1.25512632
67MP0008057_abnormal_DNA_replication1.24468422
68MP0008872_abnormal_physiological_respon1.23779842
69MP0006072_abnormal_retinal_apoptosis1.23466021
70MP0002822_catalepsy1.23024984
71MP0002078_abnormal_glucose_homeostasis1.22801706
72MP0002938_white_spotting1.21115007
73MP0004147_increased_porphyrin_level1.18976333
74MP0005636_abnormal_mineral_homeostasis1.18895937
75MP0005058_abnormal_lysosome_morphology1.18207510
76MP0001919_abnormal_reproductive_system1.17394038
77MP0002210_abnormal_sex_determination1.17020034
78MP0005501_abnormal_skin_physiology1.15185989
79MP0001905_abnormal_dopamine_level1.14382708
80MP0005551_abnormal_eye_electrophysiolog1.12327905
81MP0005389_reproductive_system_phenotype1.11620514
82MP0002971_abnormal_brown_adipose1.11466097
83MP0000313_abnormal_cell_death1.11370463
84MP0005266_abnormal_metabolism1.10309324
85MP0005451_abnormal_body_composition1.09687810
86MP0008469_abnormal_protein_level1.09439115
87MP0000604_amyloidosis1.08773208
88MP0000598_abnormal_liver_morphology1.07973588
89MP0003221_abnormal_cardiomyocyte_apopto1.07672039
90MP0005535_abnormal_body_temperature1.06198595
91MP0004133_heterotaxia1.04129507
92MP0005645_abnormal_hypothalamus_physiol1.03831463
93MP0002751_abnormal_autonomic_nervous1.03792795
94MP0004043_abnormal_pH_regulation1.03760582
95MP0008995_early_reproductive_senescence1.01618784
96MP0005075_abnormal_melanosome_morpholog1.00629387
97MP0001929_abnormal_gametogenesis0.99998190
98MP0001145_abnormal_male_reproductive0.99012542
99MP0005084_abnormal_gallbladder_morpholo0.98188660
100MP0002163_abnormal_gland_morphology0.97685934
101MP0002019_abnormal_tumor_incidence0.97681070
102MP0001730_embryonic_growth_arrest0.96913600
103MP0002909_abnormal_adrenal_gland0.96898673
104MP0001544_abnormal_cardiovascular_syste0.96554075
105MP0005385_cardiovascular_system_phenoty0.96554075
106MP0003329_amyloid_beta_deposits0.95857480
107MP0009642_abnormal_blood_homeostasis0.95586022
108MP0003011_delayed_dark_adaptation0.95416336
109MP0000538_abnormal_urinary_bladder0.93580036
110MP0003868_abnormal_feces_composition0.92861700
111MP0006276_abnormal_autonomic_nervous0.92758445
112MP0000653_abnormal_sex_gland0.92040249
113MP0004087_abnormal_muscle_fiber0.92029634
114MP0002876_abnormal_thyroid_physiology0.91999706
115MP0005394_taste/olfaction_phenotype0.91280968
116MP0005499_abnormal_olfactory_system0.91280968
117MP0009333_abnormal_splenocyte_physiolog0.89360862
118MP0009763_increased_sensitivity_to0.89315019
119MP0005671_abnormal_response_to0.88473856
120MP0003787_abnormal_imprinting0.87216733
121MP0008775_abnormal_heart_ventricle0.87200288
122MP0005376_homeostasis/metabolism_phenot0.87147581
123MP0000747_muscle_weakness0.86727388
124MP0001348_abnormal_lacrimal_gland0.86703157
125MP0000015_abnormal_ear_pigmentation0.86518866
126MP0009697_abnormal_copulation0.86229883
127MP0000350_abnormal_cell_proliferation0.85867445
128MP0005423_abnormal_somatic_nervous0.84828975
129MP0002080_prenatal_lethality0.83358663
130MP0004185_abnormal_adipocyte_glucose0.83058494
131MP0002653_abnormal_ependyma_morphology0.82454268
132MP0001697_abnormal_embryo_size0.80779086
133MP0001324_abnormal_eye_pigmentation0.80467448
134MP0005334_abnormal_fat_pad0.79877692
135MP0006138_congestive_heart_failure0.79336836
136MP0002970_abnormal_white_adipose0.79095568
137MP0009764_decreased_sensitivity_to0.78373040
138MP0002972_abnormal_cardiac_muscle0.77880190
139MP0000647_abnormal_sebaceous_gland0.77073327
140MP0002095_abnormal_skin_pigmentation0.76502675
141MP0001119_abnormal_female_reproductive0.76427256
142MP0001756_abnormal_urination0.74036560
143MP0005410_abnormal_fertilization0.73818275
144MP0003698_abnormal_male_reproductive0.72965961
145MP0003172_abnormal_lysosome_physiology0.72728710
146MP0000049_abnormal_middle_ear0.72163968
147MP0005375_adipose_tissue_phenotype0.71929297
148MP0005646_abnormal_pituitary_gland0.71921677
149MP0003763_abnormal_thymus_physiology0.71172703
150MP0005620_abnormal_muscle_contractility0.70949151
151MP0008873_increased_physiological_sensi0.70379001
152MP0005448_abnormal_energy_balance0.68980778
153MP0005380_embryogenesis_phenotype0.68508271
154MP0001672_abnormal_embryogenesis/_devel0.68508271
155MP0000490_abnormal_crypts_of0.65705497
156MP0010630_abnormal_cardiac_muscle0.64424871
157MP0003436_decreased_susceptibility_to0.64356363
158MP0005379_endocrine/exocrine_gland_phen0.64308680
159MP0001293_anophthalmia0.64125123
160MP0001853_heart_inflammation0.64019897
161MP0000685_abnormal_immune_system0.63813761
162MP0001984_abnormal_olfaction0.62769198
163MP0003567_abnormal_fetal_cardiomyocyte0.62239220
164MP0010030_abnormal_orbit_morphology0.62130106
165MP0005464_abnormal_platelet_physiology0.62075107
166MP0009765_abnormal_xenobiotic_induced0.61814906
167MP0000013_abnormal_adipose_tissue0.61726982
168MP0001765_abnormal_ion_homeostasis0.60489113
169MP0003953_abnormal_hormone_level0.60058447
170MP0000358_abnormal_cell_content/0.59857804
171MP0004142_abnormal_muscle_tone0.59363906
172MP0001661_extended_life_span0.59294960
173MP0005395_other_phenotype0.59103040
174MP0002106_abnormal_muscle_physiology0.58949741
175MP0005647_abnormal_sex_gland0.57957520
176MP0000230_abnormal_systemic_arterial0.54485339
177MP0003724_increased_susceptibility_to0.53517775
178MP0009115_abnormal_fat_cell0.53344938
179MP0008874_decreased_physiological_sensi0.51186129
180MP0003137_abnormal_impulse_conducting0.51094183
181MP0002693_abnormal_pancreas_physiology0.50300832
182MP0001835_abnormal_antigen_presentation0.49929128

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.03674077
2Intrahepatic cholestasis (HP:0001406)4.35496648
3Hypoglycemic coma (HP:0001325)4.31584009
4Ketosis (HP:0001946)4.23250603
5Abnormality of fatty-acid metabolism (HP:0004359)4.12971012
6Xanthomatosis (HP:0000991)4.10410102
7Hypobetalipoproteinemia (HP:0003563)4.08976064
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.03866601
9Hyperammonemia (HP:0001987)4.03173232
10Renal Fanconi syndrome (HP:0001994)4.00114350
11Deep venous thrombosis (HP:0002625)3.86291197
12Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.82351416
13Hepatic necrosis (HP:0002605)3.80644423
14Hyperlipoproteinemia (HP:0010980)3.73277266
15Hyperglycinuria (HP:0003108)3.66146503
16Ketoacidosis (HP:0001993)3.61124748
17Dicarboxylic aciduria (HP:0003215)3.60425863
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.60425863
19Prolonged partial thromboplastin time (HP:0003645)3.58682746
20Generalized aminoaciduria (HP:0002909)3.52241641
21Testicular atrophy (HP:0000029)3.50066341
22Cerebral edema (HP:0002181)3.48910778
23Microvesicular hepatic steatosis (HP:0001414)3.41892606
24Abnormality of glycine metabolism (HP:0010895)3.41793715
25Abnormality of serine family amino acid metabolism (HP:0010894)3.41793715
26Hyperglycinemia (HP:0002154)3.40794830
27Myoglobinuria (HP:0002913)3.32515683
28Hypolipoproteinemia (HP:0010981)3.30909526
29Type I transferrin isoform profile (HP:0003642)3.29565222
30Hepatocellular necrosis (HP:0001404)3.26813813
31Acute encephalopathy (HP:0006846)3.14767359
32Increased muscle lipid content (HP:0009058)3.09632536
33Abnormality of methionine metabolism (HP:0010901)3.02653961
34Lethargy (HP:0001254)3.01690132
35Hypoalphalipoproteinemia (HP:0003233)3.00721507
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.96932668
37Abnormal mitochondria in muscle tissue (HP:0008316)2.96690058
38Birth length less than 3rd percentile (HP:0003561)2.96499548
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.92401677
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88679608
41Late onset (HP:0003584)2.88404318
42Complement deficiency (HP:0004431)2.84982507
43Respiratory difficulties (HP:0002880)2.84681993
44Hyperbilirubinemia (HP:0002904)2.82911328
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.81817828
46Metabolic acidosis (HP:0001942)2.81541981
47Abnormal protein glycosylation (HP:0012346)2.81064397
48Abnormal glycosylation (HP:0012345)2.81064397
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.81064397
50Abnormal protein N-linked glycosylation (HP:0012347)2.81064397
51Acute necrotizing encephalopathy (HP:0006965)2.80558988
52Ragged-red muscle fibers (HP:0003200)2.80078360
53Lactic acidosis (HP:0003128)2.78691171
54Increased CSF lactate (HP:0002490)2.77942532
55Rhabdomyolysis (HP:0003201)2.74261328
56Mitochondrial inheritance (HP:0001427)2.74019100
57Abnormality of serum amino acid levels (HP:0003112)2.72198677
58Rib fusion (HP:0000902)2.68479129
59Exertional dyspnea (HP:0002875)2.67705177
60Abnormality of the common coagulation pathway (HP:0010990)2.67370980
61Increased intramyocellular lipid droplets (HP:0012240)2.64376068
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62376077
63Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60952963
64Delayed CNS myelination (HP:0002188)2.59574522
65Abnormal gallbladder morphology (HP:0012437)2.58411141
66Cholelithiasis (HP:0001081)2.56409235
67Lipid accumulation in hepatocytes (HP:0006561)2.55352462
68Epidermoid cyst (HP:0200040)2.53227770
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52579570
70Abnormality of glycolysis (HP:0004366)2.52516667
71Increased serum pyruvate (HP:0003542)2.52516667
72Ependymoma (HP:0002888)2.52412581
73Hyperinsulinemic hypoglycemia (HP:0000825)2.51623017
74Abnormality of the intrinsic pathway (HP:0010989)2.48578565
75Fat malabsorption (HP:0002630)2.47575536
76Vomiting (HP:0002013)2.46758519
77Gout (HP:0001997)2.44800788
78Absent thumb (HP:0009777)2.44131642
79Patellar aplasia (HP:0006443)2.43341006
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43327098
81Colon cancer (HP:0003003)2.41840602
82Abnormal number of erythroid precursors (HP:0012131)2.41043414
83Abnormality of the labia minora (HP:0012880)2.39852705
84Meckel diverticulum (HP:0002245)2.39413968
85Progressive microcephaly (HP:0000253)2.39093233
86Aplasia/Hypoplasia of the patella (HP:0006498)2.38049927
87Conjugated hyperbilirubinemia (HP:0002908)2.37687185
88Exercise-induced myalgia (HP:0003738)2.37145591
89Joint hemorrhage (HP:0005261)2.36458410
903-Methylglutaconic aciduria (HP:0003535)2.36333862
91Hypoplasia of the pons (HP:0012110)2.32857807
92Palpitations (HP:0001962)2.32800281
93Abnormality of the ileum (HP:0001549)2.30495453
94Increased serum lactate (HP:0002151)2.30283006
95Squamous cell carcinoma (HP:0002860)2.28237289
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25469976
97Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25469976
98Abnormality of purine metabolism (HP:0004352)2.23965239
99Reduced antithrombin III activity (HP:0001976)2.23861400
100Pendular nystagmus (HP:0012043)2.23024815
101CNS demyelination (HP:0007305)2.22715528
102Brushfield spots (HP:0001088)2.22270032
103Renal cortical cysts (HP:0000803)2.22163103
104Chromsome breakage (HP:0040012)2.22026193
105Abnormality of the preputium (HP:0100587)2.21366040
106Sudden death (HP:0001699)2.21164847
107Abnormality of nucleobase metabolism (HP:0010932)2.20064750
108Hypoglycemic seizures (HP:0002173)2.17276189
109Abnormal gallbladder physiology (HP:0012438)2.17202633
110Cholecystitis (HP:0001082)2.17202633
111Nausea (HP:0002018)2.16564019
112Hypercholesterolemia (HP:0003124)2.15089624
113Abnormality of the pons (HP:0007361)2.14513942
114Progressive macrocephaly (HP:0004481)2.14158815
115Abnormality of pyrimidine metabolism (HP:0004353)2.12263771
116Optic disc pallor (HP:0000543)2.11929877
117Attenuation of retinal blood vessels (HP:0007843)2.11901926
118Opisthotonus (HP:0002179)2.10876445
119Glycosuria (HP:0003076)2.10014796
120Abnormality of urine glucose concentration (HP:0011016)2.10014796
121Absent forearm bone (HP:0003953)2.10012857
122Aplasia involving forearm bones (HP:0009822)2.10012857
123Exercise-induced muscle cramps (HP:0003710)2.09590928
124Cerebral hypomyelination (HP:0006808)2.08883846
125Abnormality of renal resorption (HP:0011038)2.08188050
126Aplasia/Hypoplasia of the uvula (HP:0010293)2.07748827
127Horseshoe kidney (HP:0000085)2.07339629
128Skin nodule (HP:0200036)2.06529683
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06357611
130Proximal tubulopathy (HP:0000114)2.06072650
131Congenital stationary night blindness (HP:0007642)2.05956520
132Absent radius (HP:0003974)2.02588994
133Methylmalonic aciduria (HP:0012120)2.02264224
134Reticulocytopenia (HP:0001896)2.00794149
135Ventricular tachycardia (HP:0004756)2.00535240
136Pancytopenia (HP:0001876)1.98917720
137Dyschromatopsia (HP:0007641)1.98157287
138Abnormality of complement system (HP:0005339)1.97571419
139Exercise intolerance (HP:0003546)1.97325919
140Asymmetric septal hypertrophy (HP:0001670)1.96912840
141Cleft eyelid (HP:0000625)1.95700766
142Respiratory failure (HP:0002878)1.95516745
143Increased hepatocellular lipid droplets (HP:0006565)1.95199965
144Abnormality of cells of the erythroid lineage (HP:0012130)1.94983514
145Irritability (HP:0000737)1.94892954
146Hyperalaninemia (HP:0003348)1.94358655
147Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94358655
148Abnormality of alanine metabolism (HP:0010916)1.94358655
149Neonatal onset (HP:0003623)1.93895307
150Aplasia/hypoplasia of the uterus (HP:0008684)1.87226124
151Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85300412
152Degeneration of anterior horn cells (HP:0002398)1.79383615
153Abnormality of the anterior horn cell (HP:0006802)1.79383615
154Short thumb (HP:0009778)1.78732694
155Abnormality of the astrocytes (HP:0100707)1.77446335
156Astrocytoma (HP:0009592)1.77446335
157Leukodystrophy (HP:0002415)1.77356429
158Glioma (HP:0009733)1.76932973
159Aplastic anemia (HP:0001915)1.76326016
160Pancreatic cysts (HP:0001737)1.74981312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.45372484
2BUB14.16945429
3ZAK3.99494609
4VRK23.93659194
5PBK3.70409737
6TRIB33.47729299
7SRPK13.45715491
8ERN13.21236261
9PDK33.18746604
10PDK43.18746604
11FLT32.77385833
12MAP4K12.73198158
13STK162.59129473
14KDR2.58557215
15PKN22.40930584
16TLK12.17360880
17FGFR42.15580305
18NEK12.09671832
19TRIM282.04696205
20NUAK11.97783600
21TIE11.93570191
22VRK11.90885851
23OBSCN1.89209577
24PINK11.83513155
25SIK11.82389362
26CDC71.79096983
27MYLK1.72776403
28MAP3K111.70963468
29TTN1.69024594
30MUSK1.68229743
31TAOK31.67208094
32TBK11.67117817
33TTK1.66290338
34PIK3CG1.55420202
35INSRR1.51557660
36NME21.51014748
37MAPK111.49936142
38PLK31.49094095
39MAP4K21.49001511
40CCNB11.47561821
41WNK31.46957415
42CSNK1G31.44172654
43DYRK21.42207766
44BMPR1B1.38617880
45ATR1.37993009
46MAPKAPK31.35389169
47TYK21.33488365
48PLK11.32527304
49IRAK41.32374817
50PDK21.32141675
51PIM21.25446596
52EIF2AK11.24316855
53MAP2K71.23893549
54GRK71.17966432
55PHKG21.17183108
56PHKG11.17183108
57CHEK21.16952848
58ADRBK21.16343301
59CSNK1G11.14220320
60GRK61.11406738
61IKBKE1.10845029
62LMTK21.10586358
63MST41.10274649
64CSNK1A1L1.07890162
65ZAP701.04419593
66JAK31.02629837
67MAPK121.02189589
68WNK41.01943593
69GRK10.99891698
70CSNK1G20.98623073
71AURKA0.97514648
72IRAK20.97461618
73PRKCI0.97439580
74ITK0.95700167
75TAF10.95249146
76JAK20.94029590
77BRSK10.92737477
78JAK10.92352249
79ARAF0.91910299
80AURKB0.89908768
81TESK20.89890722
82PRKAA20.88233346
83CDK80.86636916
84RPS6KA50.86396007
85PLK40.85495521
86NME10.83981925
87TEC0.83153554
88TXK0.81619541
89MKNK20.80913239
90MAP2K30.78794576
91PAK40.78694877
92MKNK10.78681987
93PDPK10.78520949
94PRKAA10.75880267
95SYK0.75522295
96EIF2AK30.73544548
97MAP2K40.72162646
98CDK70.71660153
99MAP3K40.71130965
100PDK10.68253335
101CSF1R0.67834395
102KIT0.66705245
103BTK0.64723132
104CSNK2A10.63739804
105MAP3K70.63643532
106EIF2AK20.63023923
107RPS6KA40.62465017
108TNK20.62407679
109IRAK10.61536078
110NLK0.60843320
111MAP3K130.60509926
112STK40.59723357
113CHEK10.59542664
114IRAK30.58791760
115BRAF0.58027688
116DAPK10.57985721
117SIK30.57523433
118ATM0.54889771
119CSNK2A20.54234848
120PRKACG0.52732029
121DAPK30.50038550
122BRSK20.49921747
123DYRK30.48908311
124DAPK20.48901308
125PAK10.48288929
126MAP3K50.48107690
127MAP3K10.47760551
128FRK0.47447349
129SCYL20.47227321
130EEF2K0.45778691
131ABL20.44127148
132MAP2K60.43092180
133SMG10.43082786
134MAPK40.41697236
135BCR0.41039212
136STK380.37673734
137ILK0.37547661
138LCK0.37102892
139LRRK20.36684158
140NEK90.36551142
141CSK0.36532932
142PIK3CA0.36471826
143PIM10.36204497
144OXSR10.35394195
145MAP3K120.34197126
146PRKCQ0.33937203
147TSSK60.33742920
148RPS6KB20.33115245
149IKBKB0.33096667
150EPHA20.32078253
151CDK10.31078540
152MST1R0.31030021
153CDK20.30875179
154CAMK2G0.29853502
155MAPK150.29595608
156ALK0.29006376
157CAMK10.28399819
158CDK40.28172370
159CSNK1A10.26819545
160MAPKAPK50.26224647
161PRKD10.25509513
162PRKCD0.25010015
163CAMK2D0.24625987
164PRKCH0.22596123
165TESK10.22227423
166ACVR1B0.22224098
167ADRBK10.22127636
168PRKCG0.22089779
169LYN0.21971568
170CSNK1E0.21768563
171AKT20.21270619
172CAMKK20.21147507
173NEK20.21105812
174MAP3K30.20643749
175WEE10.18858791

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.50495052
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.35032070
3RNA polymerase_Homo sapiens_hsa030203.27360835
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.24621522
5DNA replication_Homo sapiens_hsa030303.22020613
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.15031357
7Fatty acid degradation_Homo sapiens_hsa000713.11029421
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99114182
9Propanoate metabolism_Homo sapiens_hsa006402.95718049
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94798421
11Mismatch repair_Homo sapiens_hsa034302.92508672
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81021818
13Base excision repair_Homo sapiens_hsa034102.72725762
14Homologous recombination_Homo sapiens_hsa034402.60803683
15Tryptophan metabolism_Homo sapiens_hsa003802.39512161
16Arginine biosynthesis_Homo sapiens_hsa002202.34397003
17Fatty acid metabolism_Homo sapiens_hsa012122.30112340
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26005779
19Carbon metabolism_Homo sapiens_hsa012002.20275796
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19143487
21Pyruvate metabolism_Homo sapiens_hsa006202.11441910
22Fanconi anemia pathway_Homo sapiens_hsa034602.09842451
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09132707
24Peroxisome_Homo sapiens_hsa041462.05865345
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04826728
26Butanoate metabolism_Homo sapiens_hsa006502.04616036
27Non-homologous end-joining_Homo sapiens_hsa034502.04098345
28Nitrogen metabolism_Homo sapiens_hsa009101.99200751
29PPAR signaling pathway_Homo sapiens_hsa033201.90383364
30Spliceosome_Homo sapiens_hsa030401.90379856
31Biosynthesis of amino acids_Homo sapiens_hsa012301.86014757
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79638002
33RNA transport_Homo sapiens_hsa030131.73389312
34beta-Alanine metabolism_Homo sapiens_hsa004101.67097819
35Nucleotide excision repair_Homo sapiens_hsa034201.62790427
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60255805
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57926608
38Fatty acid elongation_Homo sapiens_hsa000621.54981995
39Basal transcription factors_Homo sapiens_hsa030221.49673947
40Complement and coagulation cascades_Homo sapiens_hsa046101.49064129
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.47827599
42Selenocompound metabolism_Homo sapiens_hsa004501.46230156
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.45949160
44Phenylalanine metabolism_Homo sapiens_hsa003601.44373538
45Caffeine metabolism_Homo sapiens_hsa002321.42780150
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40646226
47Sulfur relay system_Homo sapiens_hsa041221.38237558
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37975449
49Folate biosynthesis_Homo sapiens_hsa007901.34153119
50Histidine metabolism_Homo sapiens_hsa003401.33163431
51RNA degradation_Homo sapiens_hsa030181.32883500
52Pentose phosphate pathway_Homo sapiens_hsa000301.30995138
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30199035
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29862651
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22918860
56Tyrosine metabolism_Homo sapiens_hsa003501.22332629
57Oxidative phosphorylation_Homo sapiens_hsa001901.21417061
58Fructose and mannose metabolism_Homo sapiens_hsa000511.21149065
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20585392
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.18921780
61Chemical carcinogenesis_Homo sapiens_hsa052041.16065470
62Starch and sucrose metabolism_Homo sapiens_hsa005001.15651704
63Parkinsons disease_Homo sapiens_hsa050121.13576054
64Sulfur metabolism_Homo sapiens_hsa009201.12874620
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08950899
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05242125
67Maturity onset diabetes of the young_Homo sapiens_hsa049501.05006591
68ABC transporters_Homo sapiens_hsa020101.03757791
69Fat digestion and absorption_Homo sapiens_hsa049751.00390307
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96489997
71Cell cycle_Homo sapiens_hsa041100.95438774
72Retinol metabolism_Homo sapiens_hsa008300.94819350
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94725373
74Bile secretion_Homo sapiens_hsa049760.93897398
75Proteasome_Homo sapiens_hsa030500.90673015
76Arginine and proline metabolism_Homo sapiens_hsa003300.89537395
77Galactose metabolism_Homo sapiens_hsa000520.85510262
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.79950474
79Vitamin B6 metabolism_Homo sapiens_hsa007500.78744461
80Staphylococcus aureus infection_Homo sapiens_hsa051500.77836876
81Glycerolipid metabolism_Homo sapiens_hsa005610.76921045
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76792183
83N-Glycan biosynthesis_Homo sapiens_hsa005100.75202087
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73758731
85Alzheimers disease_Homo sapiens_hsa050100.71846866
86Fatty acid biosynthesis_Homo sapiens_hsa000610.71202888
87* Metabolic pathways_Homo sapiens_hsa011000.70606863
88Phototransduction_Homo sapiens_hsa047440.65854176
89mRNA surveillance pathway_Homo sapiens_hsa030150.64832327
90One carbon pool by folate_Homo sapiens_hsa006700.63460129
91Cardiac muscle contraction_Homo sapiens_hsa042600.61120185
92Huntingtons disease_Homo sapiens_hsa050160.56755761
93Glutathione metabolism_Homo sapiens_hsa004800.55649263
94Protein export_Homo sapiens_hsa030600.54236602
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52134847
96Glucagon signaling pathway_Homo sapiens_hsa049220.48925571
97Epstein-Barr virus infection_Homo sapiens_hsa051690.46848886
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.45407373
99Lysine degradation_Homo sapiens_hsa003100.45271937
100p53 signaling pathway_Homo sapiens_hsa041150.43780557
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42704827
102Steroid biosynthesis_Homo sapiens_hsa001000.41970664
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36968645
104Insulin resistance_Homo sapiens_hsa049310.36259964
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35684368
106Vitamin digestion and absorption_Homo sapiens_hsa049770.35591189
107Asthma_Homo sapiens_hsa053100.35447624
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.34107947
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.33650603
110AMPK signaling pathway_Homo sapiens_hsa041520.33633752
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30802020
112Collecting duct acid secretion_Homo sapiens_hsa049660.30496797
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29738858
114Systemic lupus erythematosus_Homo sapiens_hsa053220.29301410
115Primary immunodeficiency_Homo sapiens_hsa053400.29016204
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27029622
117Pyrimidine metabolism_Homo sapiens_hsa002400.19813899
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19501885
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16804402
120Insulin signaling pathway_Homo sapiens_hsa049100.16533615
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15750101
122Other glycan degradation_Homo sapiens_hsa005110.14490039
123Regulation of autophagy_Homo sapiens_hsa041400.14475955
124Linoleic acid metabolism_Homo sapiens_hsa005910.10625231
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.09268084
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03491955
127Purine metabolism_Homo sapiens_hsa002300.02130557
128Ribosome_Homo sapiens_hsa030100.02046631
129Prion diseases_Homo sapiens_hsa050200.00648813
130Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0906919
131Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0757486

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