FLCN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in labyrinthine layer morphogenesis (GO:0060670)6.28650127
2macroautophagy (GO:0016236)4.53864518
3response to pheromone (GO:0019236)4.34311591
4retinal rod cell development (GO:0046548)3.96076959
5positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.93896252
6mannose metabolic process (GO:0006013)3.82093756
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74448874
8positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.74190995
9regulation of interferon-beta biosynthetic process (GO:0045357)3.61887621
10phosphatidylglycerol biosynthetic process (GO:0006655)3.58600637
11regulation of inositol phosphate biosynthetic process (GO:0010919)3.57139230
12positive regulation of B cell differentiation (GO:0045579)3.45195439
13regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.37538554
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37119852
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.35595905
16modulation by symbiont of host immune response (GO:0052553)3.35595905
17positive regulation by symbiont of host defense response (GO:0052509)3.35595905
18modulation by symbiont of host defense response (GO:0052031)3.35595905
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35595905
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35595905
21macrophage activation involved in immune response (GO:0002281)3.24160667
22regulation of cholesterol homeostasis (GO:2000188)3.20953336
23sodium ion export (GO:0071436)3.18310807
24positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.17743681
25positive regulation of gamma-delta T cell activation (GO:0046645)3.13437751
26detection of light stimulus involved in visual perception (GO:0050908)3.07389260
27detection of light stimulus involved in sensory perception (GO:0050962)3.07389260
28regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.04410968
29valine metabolic process (GO:0006573)3.03113580
30positive regulation of histone deacetylation (GO:0031065)3.02845847
31negative regulation of mast cell activation (GO:0033004)2.95975876
32L-alpha-amino acid transmembrane transport (GO:1902475)2.94653529
33negative regulation of bone resorption (GO:0045779)2.90951136
34positive regulation of p38MAPK cascade (GO:1900745)2.90560651
352-oxoglutarate metabolic process (GO:0006103)2.88826912
36negative regulation of granulocyte differentiation (GO:0030853)2.85477802
37creatine metabolic process (GO:0006600)2.85117642
38positive regulation of fatty acid oxidation (GO:0046321)2.81842361
39tricarboxylic acid metabolic process (GO:0072350)2.81565954
40positive regulation of cellular amide metabolic process (GO:0034250)2.79989739
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69773496
42response to host (GO:0075136)2.69773496
43response to host defenses (GO:0052200)2.69773496
44phospholipid homeostasis (GO:0055091)2.69493602
45cellular potassium ion homeostasis (GO:0030007)2.69223711
46apoptotic cell clearance (GO:0043277)2.66108328
47growth hormone receptor signaling pathway (GO:0060396)2.65755002
48COPI coating of Golgi vesicle (GO:0048205)2.65469491
49Golgi transport vesicle coating (GO:0048200)2.65469491
50regulation of interleukin-12 biosynthetic process (GO:0045075)2.64765563
51microglial cell activation (GO:0001774)2.63134178
52response to methylmercury (GO:0051597)2.62490018
53response to host immune response (GO:0052572)2.62168976
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62168976
55DNA deamination (GO:0045006)2.61358587
56myelination in peripheral nervous system (GO:0022011)2.61322286
57peripheral nervous system axon ensheathment (GO:0032292)2.61322286
58regulation of tight junction assembly (GO:2000810)2.61304218
59cellular response to ATP (GO:0071318)2.61114507
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60705042
61positive regulation of triglyceride biosynthetic process (GO:0010867)2.60079998
62prostate gland growth (GO:0060736)2.59203749
63protein kinase C signaling (GO:0070528)2.58196556
64regulation of cholesterol storage (GO:0010885)2.57173744
65CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.55788282
66activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55628671
67alpha-linolenic acid metabolic process (GO:0036109)2.54722141
68negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53949398
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.53866387
70pentose-phosphate shunt (GO:0006098)2.53855563
714-hydroxyproline metabolic process (GO:0019471)2.53425099
72protein-lipid complex assembly (GO:0065005)2.52596108
73fatty acid homeostasis (GO:0055089)2.50931224
74response to lipoprotein particle (GO:0055094)2.50644589
75regulation of ARF protein signal transduction (GO:0032012)2.49375696
76lytic vacuole organization (GO:0080171)2.48428881
77lysosome organization (GO:0007040)2.48428881
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48050467
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48006031
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48006031
81response to laminar fluid shear stress (GO:0034616)2.47830755
82cellular response to exogenous dsRNA (GO:0071360)2.45600647
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.41335220
84negative regulation of cell killing (GO:0031342)2.41335220
85alanine transport (GO:0032328)2.41134558
86basic amino acid transport (GO:0015802)2.41112208
87positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.36926221
88immunoglobulin mediated immune response (GO:0016064)2.36763741
89potassium ion import (GO:0010107)2.36294460
90regulation of p38MAPK cascade (GO:1900744)2.36280796
91positive regulation of glycogen biosynthetic process (GO:0045725)2.35526472
92positive regulation of nuclease activity (GO:0032075)2.35385655
93glycogen catabolic process (GO:0005980)2.33895463
94germinal center formation (GO:0002467)2.33732378
95positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.33209685
96eye photoreceptor cell development (GO:0042462)2.31718894
97regulation of sequestering of triglyceride (GO:0010889)2.31308902
98endoplasmic reticulum unfolded protein response (GO:0030968)2.30722777
99photoreceptor cell development (GO:0042461)2.30125238
100photoreceptor cell maintenance (GO:0045494)2.30043289
101regulation of gamma-delta T cell differentiation (GO:0045586)2.28794677
102negative regulation of tissue remodeling (GO:0034104)2.28368451
103cellular response to growth hormone stimulus (GO:0071378)2.28213069
104adaptation of signaling pathway (GO:0023058)2.27721018
105toxin transport (GO:1901998)2.27567188
106regulation of gamma-delta T cell activation (GO:0046643)2.26324599
107positive regulation of cholesterol efflux (GO:0010875)2.25706377
108I-kappaB phosphorylation (GO:0007252)2.25225578
109negative regulation of cAMP-mediated signaling (GO:0043951)2.24060222
110* negative regulation of TOR signaling (GO:0032007)2.22451357
111keratan sulfate catabolic process (GO:0042340)2.20179416
112triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.20112579
113negative regulation of bone remodeling (GO:0046851)2.20034572
114carnitine shuttle (GO:0006853)2.19577033
115regulation of fatty acid beta-oxidation (GO:0031998)2.19218069
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.18601175
117negative regulation of lipid transport (GO:0032369)2.18534677
118phosphatidylethanolamine biosynthetic process (GO:0006646)2.18516768
119cellular response to unfolded protein (GO:0034620)2.18334596
120ER-nucleus signaling pathway (GO:0006984)2.17440937
121cellular polysaccharide catabolic process (GO:0044247)2.16466634
122amyloid precursor protein catabolic process (GO:0042987)2.15956632
123negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.15635644
124negative regulation of type 2 immune response (GO:0002829)2.13068336
125neuromuscular process controlling posture (GO:0050884)2.12871871
126positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.11402260
127tryptophan catabolic process (GO:0006569)2.08621879
128indole-containing compound catabolic process (GO:0042436)2.08621879
129indolalkylamine catabolic process (GO:0046218)2.08621879
130white fat cell differentiation (GO:0050872)2.07440364
131positive regulation of CREB transcription factor activity (GO:0032793)2.07009485
132negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.04020913
133regulation of mast cell activation (GO:0033003)2.01513196
134protein localization to endosome (GO:0036010)2.01210357
135membrane depolarization during action potential (GO:0086010)2.00847873
136regulation of germinal center formation (GO:0002634)2.00468898
137positive regulation of alcohol biosynthetic process (GO:1902932)1.99550052
138calcium-mediated signaling using intracellular calcium source (GO:0035584)1.97995151
139regulation of beta-amyloid formation (GO:1902003)1.96586925
1403-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)1.95247182
141purine ribonucleoside bisphosphate metabolic process (GO:0034035)1.95247182
142negative regulation of innate immune response (GO:0045824)1.94147160
143synaptic vesicle maturation (GO:0016188)1.92888614
144membrane repolarization during cardiac muscle cell action potential (GO:0086013)1.92853760
145negative regulation of lipid storage (GO:0010888)1.90817024
146regulation of fatty acid oxidation (GO:0046320)1.88652282
147N-acetylneuraminate metabolic process (GO:0006054)1.88501050
148response to pH (GO:0009268)1.87129111
149striated muscle atrophy (GO:0014891)1.85851392
150positive regulation of defense response to virus by host (GO:0002230)1.85663217
151regulation of triglyceride biosynthetic process (GO:0010866)1.85280925
152regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.85193075
153positive regulation of Rap GTPase activity (GO:0032854)1.84152199
154cell differentiation involved in embryonic placenta development (GO:0060706)1.83936899
155interferon-gamma secretion (GO:0072643)1.83154054
156negative regulation of interleukin-1 production (GO:0032692)1.82976352
157synaptic vesicle docking involved in exocytosis (GO:0016081)1.82684256
158chondroitin sulfate catabolic process (GO:0030207)1.82558376
159T cell lineage commitment (GO:0002360)1.82146178
160positive regulation of synaptic transmission, dopaminergic (GO:0032226)1.81935818
161kynurenine metabolic process (GO:0070189)1.81652885
162regulation of membrane repolarization (GO:0060306)1.81576031
163vesicle transport along microtubule (GO:0047496)1.81068468
164regulation of action potential (GO:0098900)1.80926542
165positive regulation of fatty acid transport (GO:2000193)1.80805084
166negative regulation of nitric-oxide synthase activity (GO:0051001)1.80479878
167cellular response to ethanol (GO:0071361)1.80404386
168negative regulation of T-helper cell differentiation (GO:0045623)1.80237601
169negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)1.80237601
170proline transport (GO:0015824)1.80103890
171preassembly of GPI anchor in ER membrane (GO:0016254)1.79834689
172negative regulation of interleukin-12 production (GO:0032695)1.78655573
173gland morphogenesis (GO:0022612)1.78355122
174mitochondrion degradation (GO:0000422)1.77443101
175amino sugar catabolic process (GO:0046348)1.76464589
176negative regulation of protein oligomerization (GO:0032460)1.74362634
177positive regulation of type I interferon-mediated signaling pathway (GO:0060340)1.74259660
178positive regulation of protein deacetylation (GO:0090312)1.73809502
179NAD biosynthetic process (GO:0009435)1.73458261
180regulation of cAMP-mediated signaling (GO:0043949)1.73093429
181positive regulation of fatty acid beta-oxidation (GO:0032000)1.73010701
182urinary tract smooth muscle contraction (GO:0014848)1.72982990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human2.81818784
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.81493681
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.79396895
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.74857372
5SCL_19346495_ChIP-Seq_HPC-7_Human2.56863652
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.54981650
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50154510
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42835220
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39328918
10DROSHA_22980978_ChIP-Seq_HELA_Human2.37132498
11* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36714321
12EZH2_22144423_ChIP-Seq_EOC_Human2.32089762
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29937546
14VDR_21846776_ChIP-Seq_THP-1_Human2.21194269
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15666407
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.15481149
17* LXR_22158963_ChIP-Seq_LIVER_Mouse2.14604256
18MYC_22102868_ChIP-Seq_BL_Human2.13373073
19SPI1_23127762_ChIP-Seq_K562_Human2.12523211
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11044446
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.09544656
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05089198
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03399142
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.00942297
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00337059
26TCF7_22412390_ChIP-Seq_EML_Mouse1.96526170
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91560864
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86561444
29GATA1_19941827_ChIP-Seq_MEL_Mouse1.85275852
30KDM2B_26808549_Chip-Seq_DND41_Human1.84026949
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81469630
32* CLOCK_20551151_ChIP-Seq_293T_Human1.81087938
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80093036
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79716777
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79643606
36* TFEB_21752829_ChIP-Seq_HELA_Human1.79443562
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75363383
38SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73305943
39RUNX_20019798_ChIP-Seq_JUKART_Human1.72841377
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.72460300
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.71170628
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69618121
43GATA1_19941826_ChIP-Seq_K562_Human1.66908297
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.66518356
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64348388
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63882703
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63115336
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61625709
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60110820
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56426095
51* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52227799
52MAF_26560356_Chip-Seq_TH1_Human1.49684110
53LXR_22292898_ChIP-Seq_THP-1_Human1.45716454
54VDR_24763502_ChIP-Seq_THP-1_Human1.45460456
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44314472
56UTX_26944678_Chip-Seq_JUKART_Human1.43725502
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41195640
58* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40179463
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.40061499
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36265281
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36248072
62REST_21632747_ChIP-Seq_MESCs_Mouse1.34724070
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.33361341
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31125339
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30881958
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.30120748
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27863279
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27695280
69CIITA_25753668_ChIP-Seq_RAJI_Human1.27063685
70FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26567232
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24593474
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23184118
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23156024
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22776403
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.22568381
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.22568381
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.21656506
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21402765
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20832136
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20809898
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20393447
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.20322242
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19113774
84* GATA3_27048872_Chip-Seq_THYMUS_Human1.17696600
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17390496
86VDR_24787735_ChIP-Seq_THP-1_Human1.16252910
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15446160
88MYB_26560356_Chip-Seq_TH1_Human1.15429693
89AHR_22903824_ChIP-Seq_MCF-7_Human1.15164421
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14991625
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14922545
92GBX2_23144817_ChIP-Seq_PC3_Human1.14689674
93GATA2_19941826_ChIP-Seq_K562_Human1.12413946
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12375590
95FOXA2_19822575_ChIP-Seq_HepG2_Human1.12374014
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11723776
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11304915
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10011371
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08848875
100SPI1_23547873_ChIP-Seq_NB4_Human1.07929352
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07453372
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06172186
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.05414909
104TP53_16413492_ChIP-PET_HCT116_Human1.04082179
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.04025428
106BCOR_27268052_Chip-Seq_Bcells_Human1.03499289
107* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03032807
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03015052
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02713734
110* P68_20966046_ChIP-Seq_HELA_Human1.02359427
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.01911084
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00812064
113RARB_27405468_Chip-Seq_BRAIN_Mouse1.00122793
114PU_27001747_Chip-Seq_BMDM_Mouse1.00093798
115NCOR1_26117541_ChIP-Seq_K562_Human0.99949122
116DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99174866
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99130023
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99128220
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98800105
120KDM2B_26808549_Chip-Seq_K562_Human0.98405831
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97859958
122MYB_26560356_Chip-Seq_TH2_Human0.97697173
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97123295
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96942228
125REST_18959480_ChIP-ChIP_MESCs_Mouse0.96938613
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96902993
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96325232
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96227680
129BCL6_27268052_Chip-Seq_Bcells_Human0.95813170
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95677213
131GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95569562
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95447144
133RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95416593
134EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95416593
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95017474
136* MITF_21258399_ChIP-Seq_MELANOMA_Human0.94856458
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94402928
138OCT4_19829295_ChIP-Seq_ESCs_Human0.94372804
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.91150775
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.90644342
141* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90090378
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89485440
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89309788
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87947819
145* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84577422
146TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83581242
147* PRDM14_20953172_ChIP-Seq_ESCs_Human0.82618146
148TP53_23651856_ChIP-Seq_MEFs_Mouse0.81928223
149* SMC4_20622854_ChIP-Seq_HELA_Human0.81361367
150ZNF274_21170338_ChIP-Seq_K562_Hela0.79998490
151EED_16625203_ChIP-ChIP_MESCs_Mouse0.78281830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.28022361
2MP0005058_abnormal_lysosome_morphology4.01241648
3MP0003172_abnormal_lysosome_physiology3.66106050
4MP0003724_increased_susceptibility_to3.07976606
5MP0005670_abnormal_white_adipose2.74010083
6MP0003191_abnormal_cellular_cholesterol2.67430083
7MP0005551_abnormal_eye_electrophysiolog2.59383628
8MP0000604_amyloidosis2.16747030
9MP0005167_abnormal_blood-brain_barrier2.12833533
10MP0006072_abnormal_retinal_apoptosis2.05192461
11MP0002090_abnormal_vision2.00202168
12MP0003879_abnormal_hair_cell1.97692842
13MP0003011_delayed_dark_adaptation1.96626750
14MP0004036_abnormal_muscle_relaxation1.95313416
15MP0003950_abnormal_plasma_membrane1.92464679
16MP0005253_abnormal_eye_physiology1.89079002
17MP0002138_abnormal_hepatobiliary_system1.86878430
18MP0004130_abnormal_muscle_cell1.85724496
19MP0002837_dystrophic_cardiac_calcinosis1.81892143
20MP0004084_abnormal_cardiac_muscle1.78302009
21MP0003045_fibrosis1.78283432
22MP0001485_abnormal_pinna_reflex1.77646698
23MP0005464_abnormal_platelet_physiology1.77645845
24MP0004147_increased_porphyrin_level1.76802856
25MP0002064_seizures1.71702844
26MP0002876_abnormal_thyroid_physiology1.68575123
27MP0004510_myositis1.68396355
28MP0002638_abnormal_pupillary_reflex1.67706027
29MP0003690_abnormal_glial_cell1.65765973
30MP0004145_abnormal_muscle_electrophysio1.65688939
31MP0003329_amyloid_beta_deposits1.65262321
32MP0001501_abnormal_sleep_pattern1.64564844
33MP0001849_ear_inflammation1.64378100
34MP0005666_abnormal_adipose_tissue1.61943789
35MP0002269_muscular_atrophy1.59489856
36MP0003436_decreased_susceptibility_to1.56126968
37MP0005365_abnormal_bile_salt1.55001299
38MP0009046_muscle_twitch1.54065236
39MP0009785_altered_susceptibility_to1.51983206
40MP0003183_abnormal_peptide_metabolism1.50771241
41MP0006082_CNS_inflammation1.48297057
42MP0004043_abnormal_pH_regulation1.48262434
43MP0003279_aneurysm1.48128617
44MP0002877_abnormal_melanocyte_morpholog1.44795673
45MP0002419_abnormal_innate_immunity1.42818853
46MP0004858_abnormal_nervous_system1.42474137
47MP0001324_abnormal_eye_pigmentation1.40528733
48MP0003656_abnormal_erythrocyte_physiolo1.39545959
49MP0004859_abnormal_synaptic_plasticity1.39449597
50MP0000749_muscle_degeneration1.39427934
51MP0001835_abnormal_antigen_presentation1.38235819
52MP0000685_abnormal_immune_system1.37428450
53MP0009764_decreased_sensitivity_to1.37291347
54MP0002148_abnormal_hypersensitivity_rea1.36126173
55MP0000569_abnormal_digit_pigmentation1.35488398
56MP0003635_abnormal_synaptic_transmissio1.33572217
57MP0009745_abnormal_behavioral_response1.31537372
58MP0000747_muscle_weakness1.31110840
59MP0008961_abnormal_basal_metabolism1.31043731
60MP0001502_abnormal_circadian_rhythm1.29037530
61MP0002653_abnormal_ependyma_morphology1.28177070
62MP0003646_muscle_fatigue1.27838211
63MP0005646_abnormal_pituitary_gland1.26966627
64MP0005375_adipose_tissue_phenotype1.26666182
65MP0000015_abnormal_ear_pigmentation1.26427209
66MP0002998_abnormal_bone_remodeling1.25295958
67MP0010329_abnormal_lipoprotein_level1.23703420
68MP0005367_renal/urinary_system_phenotyp1.23582938
69MP0000516_abnormal_urinary_system1.23582938
70MP0000609_abnormal_liver_physiology1.21678013
71MP0004947_skin_inflammation1.20654443
72MP0002063_abnormal_learning/memory/cond1.17803202
73MP0003303_peritoneal_inflammation1.16381048
74MP0005310_abnormal_salivary_gland1.15782817
75MP0002118_abnormal_lipid_homeostasis1.14082100
76MP0008872_abnormal_physiological_respon1.13884514
77MP0003633_abnormal_nervous_system1.13373953
78MP0000751_myopathy1.11775883
79MP0009384_cardiac_valve_regurgitation1.10752794
80MP0004087_abnormal_muscle_fiber1.10127075
81MP0004233_abnormal_muscle_weight1.10033870
82MP0004185_abnormal_adipocyte_glucose1.09941153
83MP0003195_calcinosis1.09282489
84MP0001440_abnormal_grooming_behavior1.08376397
85MP0000371_diluted_coat_color1.07007196
86MP0005195_abnormal_posterior_eye1.05489708
87MP0002971_abnormal_brown_adipose1.05130855
88MP0002272_abnormal_nervous_system1.04899590
89MP0003075_altered_response_to1.04739254
90MP0004885_abnormal_endolymph1.04053222
91MP0002078_abnormal_glucose_homeostasis1.03472688
92MP0002452_abnormal_antigen_presenting1.03287972
93MP0005387_immune_system_phenotype1.03141264
94MP0001790_abnormal_immune_system1.03141264
95MP0002909_abnormal_adrenal_gland1.02203991
96MP0001800_abnormal_humoral_immune1.02070125
97MP0002332_abnormal_exercise_endurance1.01830735
98MP0002139_abnormal_hepatobiliary_system1.01671548
99MP0002229_neurodegeneration1.01603081
100MP0003252_abnormal_bile_duct1.01112505
101MP0005671_abnormal_response_to1.00002704
102MP0009278_abnormal_bone_marrow0.99377125
103MP0003300_gastrointestinal_ulcer0.98872757
104MP0000003_abnormal_adipose_tissue0.98732596
105MP0004270_analgesia0.98443660
106MP0005083_abnormal_biliary_tract0.97814475
107MP0001986_abnormal_taste_sensitivity0.96358485
108MP0001533_abnormal_skeleton_physiology0.96173401
109MP0010630_abnormal_cardiac_muscle0.96062916
110MP0005174_abnormal_tail_pigmentation0.95978949
111MP0005330_cardiomyopathy0.95038143
112MP0003705_abnormal_hypodermis_morpholog0.94915972
113MP0001765_abnormal_ion_homeostasis0.94488727
114MP0002572_abnormal_emotion/affect_behav0.94081978
115MP0003634_abnormal_glial_cell0.94061845
116MP0000343_altered_response_to0.93758546
117MP0002723_abnormal_immune_serum0.93690921
118MP0009765_abnormal_xenobiotic_induced0.92359893
119MP0005000_abnormal_immune_tolerance0.90089771
120MP0004215_abnormal_myocardial_fiber0.89995004
121MP0000920_abnormal_myelination0.88857371
122MP0000230_abnormal_systemic_arterial0.88797196
123MP0002693_abnormal_pancreas_physiology0.86511277
124MP0002089_abnormal_postnatal_growth/wei0.85932925
125MP0001756_abnormal_urination0.85721480
126MP0003283_abnormal_digestive_organ0.84761600
127MP0005451_abnormal_body_composition0.84248154
128MP0001958_emphysema0.83839891
129MP0008775_abnormal_heart_ventricle0.83828967
130MP0003631_nervous_system_phenotype0.83378006
131MP0008469_abnormal_protein_level0.82130157
132MP0002396_abnormal_hematopoietic_system0.81673010
133MP0005319_abnormal_enzyme/_coenzyme0.80862686
134MP0000689_abnormal_spleen_morphology0.80485862
135MP0002733_abnormal_thermal_nociception0.80390523
136MP0002420_abnormal_adaptive_immunity0.79725726
137MP0001970_abnormal_pain_threshold0.79389433
138MP0002405_respiratory_system_inflammati0.79376498
139MP0005025_abnormal_response_to0.79045546
140MP0002106_abnormal_muscle_physiology0.78535215
141MP0005391_vision/eye_phenotype0.78290877
142MP0004484_altered_response_of0.78062612
143MP0002933_joint_inflammation0.77985029
144MP0005334_abnormal_fat_pad0.77911187
145MP0001819_abnormal_immune_cell0.77880857
146MP0009763_increased_sensitivity_to0.77310473
147MP0001853_heart_inflammation0.76220739
148MP0001968_abnormal_touch/_nociception0.76031033
149MP0001915_intracranial_hemorrhage0.75603404
150MP0005076_abnormal_cell_differentiation0.75284275
151MP0003566_abnormal_cell_adhesion0.75044166
152MP0005257_abnormal_intraocular_pressure0.74835522
153MP0000013_abnormal_adipose_tissue0.74335280
154MP0001845_abnormal_inflammatory_respons0.74261045
155MP0005085_abnormal_gallbladder_physiolo0.74161233
156MP0002127_abnormal_cardiovascular_syste0.74159915
157MP0002254_reproductive_system_inflammat0.73406486

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.22486564
2Increased neuronal autofluorescent lipopigment (HP:0002074)4.92923850
3Congenital stationary night blindness (HP:0007642)4.74459050
4Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.28261224
5Short 1st metacarpal (HP:0010034)4.28261224
6Central scotoma (HP:0000603)4.27890071
7Dysostosis multiplex (HP:0000943)4.09562679
8Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.02481362
9Asymmetric septal hypertrophy (HP:0001670)3.76347085
10Abnormality of the 1st metacarpal (HP:0010009)3.70224271
11Abnormality of glycolipid metabolism (HP:0010969)3.62131082
12Abnormality of liposaccharide metabolism (HP:0010968)3.62131082
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.62131082
14Abnormality of polysaccharide metabolism (HP:0011012)3.60580135
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.60580135
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.60580135
17Neurofibrillary tangles (HP:0002185)3.59084522
18Mucopolysacchariduria (HP:0008155)3.55290779
19Urinary glycosaminoglycan excretion (HP:0003541)3.55290779
20Abnormal rod and cone electroretinograms (HP:0008323)3.51396472
21Bony spicule pigmentary retinopathy (HP:0007737)3.50065104
22Abnormality of macular pigmentation (HP:0008002)3.40747480
23Scotoma (HP:0000575)3.30792601
24Hematochezia (HP:0002573)3.16627153
25Systemic lupus erythematosus (HP:0002725)3.05161072
26Ectopic kidney (HP:0000086)2.97575599
27Abnormality of the renal collecting system (HP:0004742)2.93163906
28Progressive visual loss (HP:0000529)2.88399782
29Congenital sensorineural hearing impairment (HP:0008527)2.87368315
30Duplicated collecting system (HP:0000081)2.82982969
31Exercise-induced myalgia (HP:0003738)2.81863042
32Genetic anticipation (HP:0003743)2.81643766
33Diplopia (HP:0000651)2.78357832
34Abnormality of binocular vision (HP:0011514)2.78357832
35Abolished electroretinogram (ERG) (HP:0000550)2.76233027
36Cerebral inclusion bodies (HP:0100314)2.72657924
37Global brain atrophy (HP:0002283)2.71679851
38Retinal atrophy (HP:0001105)2.68434600
39Myoglobinuria (HP:0002913)2.67358799
40Short phalanx of the thumb (HP:0009660)2.66193996
41Vacuolated lymphocytes (HP:0001922)2.63721939
42Cerebral aneurysm (HP:0004944)2.63624162
43Exercise-induced muscle cramps (HP:0003710)2.61083718
44Onion bulb formation (HP:0003383)2.60987905
45Supranuclear gaze palsy (HP:0000605)2.57208554
46Recurrent bacterial skin infections (HP:0005406)2.55851357
47Hemiplegia (HP:0002301)2.55831723
48Severe visual impairment (HP:0001141)2.55621224
49Loss of speech (HP:0002371)2.50810297
50Ketoacidosis (HP:0001993)2.47087566
51Hyperventilation (HP:0002883)2.43019396
52Progressive cerebellar ataxia (HP:0002073)2.40884842
53Prolonged QT interval (HP:0001657)2.39991339
54Recurrent abscess formation (HP:0002722)2.37845177
55Albinism (HP:0001022)2.36904250
56Spondylolisthesis (HP:0003302)2.36886801
57Progressive neurologic deterioration (HP:0002344)2.36061508
58Axonal loss (HP:0003447)2.33891395
59Pigmentary retinal degeneration (HP:0001146)2.33697340
60Glomerulonephritis (HP:0000099)2.32469844
61Osteomalacia (HP:0002749)2.30732418
62Chorioretinal atrophy (HP:0000533)2.29054263
63Complement deficiency (HP:0004431)2.28326775
64Abnormality of the fovea (HP:0000493)2.28102365
65Poikilocytosis (HP:0004447)2.27017062
66Febrile seizures (HP:0002373)2.26973847
67Abnormality of DNA repair (HP:0003254)2.25299455
68Ventricular fibrillation (HP:0001663)2.25078421
69Stomatitis (HP:0010280)2.24766755
70Ketosis (HP:0001946)2.24450859
71Neuronal loss in central nervous system (HP:0002529)2.24033719
72Hypoalphalipoproteinemia (HP:0003233)2.23882521
73Absent thumb (HP:0009777)2.22823678
74Carpal bone hypoplasia (HP:0001498)2.21734439
75Tachypnea (HP:0002789)2.21625205
76Stenosis of the external auditory canal (HP:0000402)2.18469464
77Interstitial pulmonary disease (HP:0006530)2.16579662
78Pendular nystagmus (HP:0012043)2.15498447
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15052924
80Protruding tongue (HP:0010808)2.13358629
81Abnormal EKG (HP:0003115)2.13353041
82Status epilepticus (HP:0002133)2.12702726
83Visual hallucinations (HP:0002367)2.12676635
84Arterial tortuosity (HP:0005116)2.12505940
85Truncal ataxia (HP:0002078)2.12001563
86Fused cervical vertebrae (HP:0002949)2.11776661
87Abnormality of macrophages (HP:0004311)2.10730314
88Orchitis (HP:0100796)2.09444418
89Tetraparesis (HP:0002273)2.09397633
90Short hallux (HP:0010109)2.09211418
91Xanthomatosis (HP:0000991)2.08696429
92Obstructive sleep apnea (HP:0002870)2.08297217
93Upper motor neuron abnormality (HP:0002127)2.08234649
94Retrobulbar optic neuritis (HP:0100654)2.08096551
95Optic neuritis (HP:0100653)2.08096551
96Intestinal fistula (HP:0100819)2.07727070
97Aplasia/Hypoplasia of the fovea (HP:0008060)2.07430907
98Hypoplasia of the fovea (HP:0007750)2.07430907
99Recurrent fungal infections (HP:0002841)2.07387997
100Aplasia/Hypoplasia of the macula (HP:0008059)2.05630828
101Insulin-resistant diabetes mellitus (HP:0000831)2.05501932
102Myositis (HP:0100614)2.03518196
103Thyroiditis (HP:0100646)2.03461335
104Macroglossia (HP:0000158)2.03203776
105Acanthocytosis (HP:0001927)2.02614998
106Colitis (HP:0002583)2.02237144
107Paralysis (HP:0003470)2.00776234
108Late onset (HP:0003584)2.00719994
109Gaze-evoked nystagmus (HP:0000640)1.98752966
110Clumsiness (HP:0002312)1.98067736
111Hand muscle atrophy (HP:0009130)1.97557751
112Tented upper lip vermilion (HP:0010804)1.97463054
113Hyperinsulinemic hypoglycemia (HP:0000825)1.96774711
114Aneurysm (HP:0002617)1.96561022
115Leukocytosis (HP:0001974)1.96276765
116Macular degeneration (HP:0000608)1.96143071
117Restrictive lung disease (HP:0002091)1.95759866
118Aplasia/Hypoplasia affecting the retina (HP:0008061)1.94966563
119Vascular tortuosity (HP:0004948)1.94602510
120Ocular albinism (HP:0001107)1.94222378
121Hypoplasia of the thymus (HP:0000778)1.93988810
122Hypoglycemic coma (HP:0001325)1.92844319
123Posterior subcapsular cataract (HP:0007787)1.92332577
124Oligomenorrhea (HP:0000876)1.91703678
125Hypoplasia of the odontoid process (HP:0003311)1.90754727
126Severe muscular hypotonia (HP:0006829)1.90255235
127Abnormality of endocrine pancreas physiology (HP:0012093)1.90156049
128Abnormality of the pancreatic islet cells (HP:0006476)1.90156049
129Myocardial infarction (HP:0001658)1.89629337
130Type II diabetes mellitus (HP:0005978)1.88953353
131Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87858856
132Hypoglycemic seizures (HP:0002173)1.87857604
133Upper limb amyotrophy (HP:0009129)1.87633299
134Distal upper limb amyotrophy (HP:0007149)1.87633299
135Aplasia/Hypoplasia of the hallux (HP:0008362)1.87082857
136Stereotypic behavior (HP:0000733)1.86336945
137Spontaneous hematomas (HP:0007420)1.85877726
138Toxemia of pregnancy (HP:0100603)1.85614803
139Impaired smooth pursuit (HP:0007772)1.84824784
140Hypochromic microcytic anemia (HP:0004840)1.84760049
141Cone-rod dystrophy (HP:0000548)1.83823103
142Broad-based gait (HP:0002136)1.82321628
143Eczematoid dermatitis (HP:0000976)1.81687187
144Hemiparesis (HP:0001269)1.79690698
145Broad metatarsal (HP:0001783)1.79602438
146Attenuation of retinal blood vessels (HP:0007843)1.79499465
147Focal seizures (HP:0007359)1.78570133
148Abnormality of the odontoid process (HP:0003310)1.77589772
149Abnormal delayed hypersensitivity skin test (HP:0002963)1.77588948
150Hypochromic anemia (HP:0001931)1.77291889
151Abnormality of vision evoked potentials (HP:0000649)1.75875741
152Skin nodule (HP:0200036)1.75367769
153Chronic mucocutaneous candidiasis (HP:0002728)1.74466598
154Recurrent cutaneous fungal infections (HP:0011370)1.74466598
155Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.74280801
156Persistence of primary teeth (HP:0006335)1.73151152
157Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72729231
158Hemoptysis (HP:0002105)1.72702863
159Postural instability (HP:0002172)1.72290680
160Syncope (HP:0001279)1.72131423
161Rectovaginal fistula (HP:0000143)1.71511789
162Rectal fistula (HP:0100590)1.71511789
163Decreased circulating renin level (HP:0003351)1.71114150
164T lymphocytopenia (HP:0005403)1.71100014
165Rectal prolapse (HP:0002035)1.70789999
166EMG: neuropathic changes (HP:0003445)1.70316002
167Recurrent gram-negative bacterial infections (HP:0005420)1.70263193
168Difficulty running (HP:0009046)1.66967007
169Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.66965557
170Mutism (HP:0002300)1.66664760
171Disinhibition (HP:0000734)1.64314947
172Subcapsular cataract (HP:0000523)1.64258146
173Mitral stenosis (HP:0001718)1.64205512
174Dementia (HP:0000726)1.64196347
175Abnormality of proline metabolism (HP:0010907)1.63942514
176Hydroxyprolinuria (HP:0003080)1.63942514
177Aortic aneurysm (HP:0004942)1.63665373
178Fatigue (HP:0012378)1.61119185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.51221934
2TAOK33.19926308
3TRIB33.17751107
4ERN13.04909175
5PKN22.85421379
6FLT32.64311137
7DAPK22.56198962
8TGFBR22.52327237
9MAP3K102.46027970
10INSRR2.29843126
11EEF2K2.22114278
12MAP3K132.21448280
13ADRBK22.09480479
14BCKDK2.08730095
15TTN2.07844971
16KIT1.89899609
17GRK11.87900967
18SIK11.86557933
19ACVR1B1.86465474
20CDC42BPA1.82253612
21MAP4K11.78841192
22TYK21.70799289
23CAMK1D1.65334041
24PINK11.56985613
25JAK31.55992951
26BLK1.55527969
27TBK11.54151695
28MAP3K111.51647692
29CSF1R1.49991042
30KSR21.48669646
31MAPK151.44489831
32NTRK31.43159403
33PTK61.32089065
34TXK1.27138489
35MAP3K91.25825038
36HIPK21.25078090
37MAP3K71.20945439
38ICK1.20803128
39CAMKK11.20009609
40EPHB11.19321821
41CAMK1G1.17848701
42BRD41.17064515
43JAK11.17021587
44PHKG11.16296980
45PHKG21.16296980
46PIK3CG1.16071586
47MAP2K61.15299861
48TNK21.15130608
49SYK1.08792617
50AKT31.08410774
51MAP3K31.06149548
52SGK21.06033775
53STK111.04292437
54JAK21.04135766
55PRPF4B1.03956943
56MAP3K141.03235834
57PAK61.02998535
58MAP2K11.00173677
59TLK11.00163985
60RIPK11.00009039
61WNK10.98083242
62CDK120.97620759
63NEK10.96833513
64GRK70.95301225
65PRKD30.94698053
66RPS6KA60.94466632
67SGK4940.93685695
68SGK2230.93685695
69PRKAA20.92484550
70MAP2K30.92261458
71BMX0.90392409
72EPHA30.89840787
73RPS6KA20.89221014
74STK380.88998841
75CAMK10.88975672
76MOS0.84726725
77DMPK0.84406894
78PRKAA10.83281694
79MAPKAPK30.82925270
80MARK20.82284666
81BTK0.81852976
82BMPR1B0.80792615
83PRKD20.80707151
84RPS6KL10.78728057
85RPS6KC10.78728057
86PTK2B0.78652738
87STK100.78207478
88CAMKK20.77964168
89IKBKB0.77689633
90ZAP700.76362215
91IRAK30.76059571
92LMTK20.75536549
93SCYL20.75117904
94PRKD10.74292905
95MAPK70.73688780
96CLK10.72190085
97MAPK120.70780760
98RIPK40.70694886
99HCK0.69238309
100NEK90.68935348
101LATS10.68802565
102RAF10.68659457
103RET0.67939370
104MTOR0.67266510
105TAOK10.66706111
106CDK90.66550275
107TYRO30.62228528
108MAP3K10.61583394
109CHUK0.61578389
110FGFR40.60154929
111PTK20.60140253
112PDK10.60112791
113ITK0.59648842
114CSK0.59539485
115GRK60.58967440
116SGK30.58937895
117PDGFRB0.58613817
118MET0.58149498
119LYN0.57888149
120MAP2K40.57808743
121DDR20.56113586
122FGFR20.55753940
123PRKCH0.55395006
124SIK20.55201548
125IKBKE0.54772356
126FGFR30.54489975
127SGK10.54484600
128ADRBK10.54371306
129FES0.54049404
130MAPK110.52850530
131DYRK1B0.51947395
132PDPK10.51899097
133PAK40.51712087
134PASK0.51018519
135LCK0.48788341
136MATK0.47207027
137TRPM70.45245657
138IRAK40.43417399
139STK40.41667665
140MAP3K60.38106858
141CAMK40.37917286
142OBSCN0.37153564
143PAK20.35485351
144MAP3K20.35277255

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.33671544
2Lysosome_Homo sapiens_hsa041422.98717025
3Other glycan degradation_Homo sapiens_hsa005112.87379402
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.46005359
5Staphylococcus aureus infection_Homo sapiens_hsa051502.00974013
6Maturity onset diabetes of the young_Homo sapiens_hsa049501.85592629
7Nitrogen metabolism_Homo sapiens_hsa009101.84902535
8Fatty acid degradation_Homo sapiens_hsa000711.84234302
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79804155
10Circadian rhythm_Homo sapiens_hsa047101.74557951
11Lysine degradation_Homo sapiens_hsa003101.71308075
12Dorso-ventral axis formation_Homo sapiens_hsa043201.68811842
13ABC transporters_Homo sapiens_hsa020101.64974986
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63611303
15Fructose and mannose metabolism_Homo sapiens_hsa000511.63551147
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.63275995
17Collecting duct acid secretion_Homo sapiens_hsa049661.59656777
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59276791
19Type II diabetes mellitus_Homo sapiens_hsa049301.55765722
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50656607
21Selenocompound metabolism_Homo sapiens_hsa004501.46854048
22Biosynthesis of amino acids_Homo sapiens_hsa012301.43577048
23Insulin resistance_Homo sapiens_hsa049311.39297209
24B cell receptor signaling pathway_Homo sapiens_hsa046621.37403300
25Osteoclast differentiation_Homo sapiens_hsa043801.36457343
26Galactose metabolism_Homo sapiens_hsa000521.33506313
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33451510
28mTOR signaling pathway_Homo sapiens_hsa041501.22778143
29Fatty acid metabolism_Homo sapiens_hsa012121.22669793
30Morphine addiction_Homo sapiens_hsa050321.17710491
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.16318875
32Phototransduction_Homo sapiens_hsa047441.13526271
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.13095061
34Complement and coagulation cascades_Homo sapiens_hsa046101.12587115
35Renin-angiotensin system_Homo sapiens_hsa046141.10982207
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10517723
37PPAR signaling pathway_Homo sapiens_hsa033201.10338201
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08191639
39Circadian entrainment_Homo sapiens_hsa047131.07253513
40Pentose phosphate pathway_Homo sapiens_hsa000301.06162991
41Carbon metabolism_Homo sapiens_hsa012001.04797980
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03937997
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03063563
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00349822
45Rheumatoid arthritis_Homo sapiens_hsa053230.99931286
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.99583370
47Type I diabetes mellitus_Homo sapiens_hsa049400.99423499
48Glutamatergic synapse_Homo sapiens_hsa047240.98743645
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98718443
50TNF signaling pathway_Homo sapiens_hsa046680.96372445
51Starch and sucrose metabolism_Homo sapiens_hsa005000.95475291
52Graft-versus-host disease_Homo sapiens_hsa053320.95139519
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94875568
54Chronic myeloid leukemia_Homo sapiens_hsa052200.94253450
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.91803217
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91255352
57Malaria_Homo sapiens_hsa051440.91252635
58Acute myeloid leukemia_Homo sapiens_hsa052210.91078643
59Ether lipid metabolism_Homo sapiens_hsa005650.90052371
60Dilated cardiomyopathy_Homo sapiens_hsa054140.89937556
61Nicotine addiction_Homo sapiens_hsa050330.89837592
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88166640
63AMPK signaling pathway_Homo sapiens_hsa041520.87824246
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87491817
65GnRH signaling pathway_Homo sapiens_hsa049120.87350180
66Allograft rejection_Homo sapiens_hsa053300.87202529
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87149212
68Caffeine metabolism_Homo sapiens_hsa002320.87093282
69GABAergic synapse_Homo sapiens_hsa047270.86845077
70Renin secretion_Homo sapiens_hsa049240.86710878
71Oxytocin signaling pathway_Homo sapiens_hsa049210.86480707
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.86361658
73Pancreatic cancer_Homo sapiens_hsa052120.86218017
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85779486
75Regulation of autophagy_Homo sapiens_hsa041400.84323427
76Tryptophan metabolism_Homo sapiens_hsa003800.83400655
77Ovarian steroidogenesis_Homo sapiens_hsa049130.83083592
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.82437359
79Calcium signaling pathway_Homo sapiens_hsa040200.82036328
80Cholinergic synapse_Homo sapiens_hsa047250.81678866
81Gastric acid secretion_Homo sapiens_hsa049710.81568301
82Linoleic acid metabolism_Homo sapiens_hsa005910.81432730
83Hematopoietic cell lineage_Homo sapiens_hsa046400.81142861
84Insulin secretion_Homo sapiens_hsa049110.81125926
85African trypanosomiasis_Homo sapiens_hsa051430.80946441
86Inositol phosphate metabolism_Homo sapiens_hsa005620.80761207
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80725965
88VEGF signaling pathway_Homo sapiens_hsa043700.79540878
89Asthma_Homo sapiens_hsa053100.78146002
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76229697
91Salivary secretion_Homo sapiens_hsa049700.75657604
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75355868
93Leishmaniasis_Homo sapiens_hsa051400.75283647
94Prion diseases_Homo sapiens_hsa050200.74281865
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.73918395
96Mineral absorption_Homo sapiens_hsa049780.73197406
97Bile secretion_Homo sapiens_hsa049760.72926823
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72727106
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71909526
100cAMP signaling pathway_Homo sapiens_hsa040240.70945741
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70734417
102Autoimmune thyroid disease_Homo sapiens_hsa053200.70450556
103Peroxisome_Homo sapiens_hsa041460.70331175
104Propanoate metabolism_Homo sapiens_hsa006400.70010696
105MAPK signaling pathway_Homo sapiens_hsa040100.69640558
106T cell receptor signaling pathway_Homo sapiens_hsa046600.68777060
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68579168
108Glucagon signaling pathway_Homo sapiens_hsa049220.67675688
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67580307
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67394112
111Insulin signaling pathway_Homo sapiens_hsa049100.67062077
112Primary immunodeficiency_Homo sapiens_hsa053400.66602545
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66241555
114Tuberculosis_Homo sapiens_hsa051520.65704608
115FoxO signaling pathway_Homo sapiens_hsa040680.64837224
116Sphingolipid metabolism_Homo sapiens_hsa006000.64700694
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64069573
118Notch signaling pathway_Homo sapiens_hsa043300.63935847
119Long-term potentiation_Homo sapiens_hsa047200.62546108
120Dopaminergic synapse_Homo sapiens_hsa047280.61328881
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61277680
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.60791173
123Amphetamine addiction_Homo sapiens_hsa050310.60580802
124Vitamin B6 metabolism_Homo sapiens_hsa007500.60255678
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60120360
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59783006
127Platelet activation_Homo sapiens_hsa046110.58604107
128HIF-1 signaling pathway_Homo sapiens_hsa040660.58554256
129Glycerolipid metabolism_Homo sapiens_hsa005610.58425118
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58322295
131Long-term depression_Homo sapiens_hsa047300.58108136
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57767168
133Arginine biosynthesis_Homo sapiens_hsa002200.55504761
134Hepatitis C_Homo sapiens_hsa051600.54988587
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54264802
136Folate biosynthesis_Homo sapiens_hsa007900.53465585
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.52292500
138Apoptosis_Homo sapiens_hsa042100.52040615
139Butanoate metabolism_Homo sapiens_hsa006500.49992151
140Prolactin signaling pathway_Homo sapiens_hsa049170.49374266
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49284612
142Non-small cell lung cancer_Homo sapiens_hsa052230.47932534
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47510774
144* Renal cell carcinoma_Homo sapiens_hsa052110.47247536
145Sulfur relay system_Homo sapiens_hsa041220.46790894
146Chemokine signaling pathway_Homo sapiens_hsa040620.46492617
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.45563058
148Legionellosis_Homo sapiens_hsa051340.44716381
149Measles_Homo sapiens_hsa051620.43818353
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43677694
151Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43240507
152Synaptic vesicle cycle_Homo sapiens_hsa047210.43091842
153Choline metabolism in cancer_Homo sapiens_hsa052310.42400874
154Toxoplasmosis_Homo sapiens_hsa051450.41058858
155Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40985210
156Jak-STAT signaling pathway_Homo sapiens_hsa046300.39675087
157Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38819787
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38590614
159Fatty acid biosynthesis_Homo sapiens_hsa000610.38074818

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