FLG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* water homeostasis (GO:0030104)9.96202972
2hair cycle (GO:0042633)9.66304494
3molting cycle (GO:0042303)9.66304494
4peptide cross-linking (GO:0018149)9.05720880
5keratinocyte proliferation (GO:0043616)7.85554247
6* keratinocyte differentiation (GO:0030216)7.00561814
7skin morphogenesis (GO:0043589)6.96843437
8hemidesmosome assembly (GO:0031581)6.49199288
9fatty acid elongation (GO:0030497)6.20659374
10long-chain fatty acid biosynthetic process (GO:0042759)5.87499835
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.80537372
12* epidermal cell differentiation (GO:0009913)5.71682796
13epidermis development (GO:0008544)5.59015205
14intermediate filament organization (GO:0045109)5.53144281
15phosphatidylinositol acyl-chain remodeling (GO:0036149)5.36455358
16adhesion of symbiont to host cell (GO:0044650)5.36044670
17virion attachment to host cell (GO:0019062)5.36044670
18phosphatidylserine acyl-chain remodeling (GO:0036150)5.27194639
19surfactant homeostasis (GO:0043129)4.96573603
20lateral sprouting from an epithelium (GO:0060601)4.96463936
21epithelial cell differentiation involved in prostate gland development (GO:0060742)4.84908843
22detection of bacterium (GO:0016045)4.78782651
23phospholipid efflux (GO:0033700)4.68811258
24polarized epithelial cell differentiation (GO:0030859)4.66013692
25skin development (GO:0043588)4.55763900
26glucosamine-containing compound catabolic process (GO:1901072)4.42808888
27adhesion of symbiont to host (GO:0044406)4.42413019
28chemical homeostasis within a tissue (GO:0048875)4.35940802
29regulation of transforming growth factor beta1 production (GO:0032908)4.30147399
30positive regulation of cholesterol efflux (GO:0010875)4.28374832
31linoleic acid metabolic process (GO:0043651)4.22947028
32phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.13361225
33detection of other organism (GO:0098543)4.13082719
34phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.07346500
35positive regulation of glomerulus development (GO:0090193)4.02868813
36negative regulation of interferon-gamma production (GO:0032689)3.80522993
37positive regulation of sterol transport (GO:0032373)3.74478804
38positive regulation of cholesterol transport (GO:0032376)3.74478804
39fibrinolysis (GO:0042730)3.65666520
40phosphatidylcholine acyl-chain remodeling (GO:0036151)3.61695204
41gap junction assembly (GO:0016264)3.60615542
42ectoderm development (GO:0007398)3.56839975
43regulation of keratinocyte differentiation (GO:0045616)3.56447616
44intermediate filament cytoskeleton organization (GO:0045104)3.50483597
45lipoxygenase pathway (GO:0019372)3.47821911
46regulation of cell proliferation involved in kidney development (GO:1901722)3.46963088
47intermediate filament-based process (GO:0045103)3.45524699
48long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.41210987
49ceramide biosynthetic process (GO:0046513)3.35747979
50hair cell differentiation (GO:0035315)3.35144170
51long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.32717507
52G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.28787281
53planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27867102
54phosphatidylserine metabolic process (GO:0006658)3.27297733
55hair follicle morphogenesis (GO:0031069)3.19575968
56melanin biosynthetic process (GO:0042438)3.18335883
57intestinal epithelial cell development (GO:0060576)3.17039151
58phospholipid catabolic process (GO:0009395)3.16029274
59keratinocyte development (GO:0003334)3.15306220
60fatty-acyl-CoA biosynthetic process (GO:0046949)3.09019895
61protein heterotrimerization (GO:0070208)3.08512363
62negative regulation of cell fate specification (GO:0009996)3.08049313
63regulation of cholesterol efflux (GO:0010874)3.07979433
64positive regulation of interleukin-8 secretion (GO:2000484)3.03498333
65hormone catabolic process (GO:0042447)3.02615966
66* establishment of skin barrier (GO:0061436)22.8615963
67keratinization (GO:0031424)21.1219244
68regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.99089390
69regulation of cholesterol homeostasis (GO:2000188)2.98826085
70regulation of natural killer cell differentiation (GO:0032823)2.98212848
71melanin metabolic process (GO:0006582)2.95967436
72very long-chain fatty acid metabolic process (GO:0000038)2.91675010
73regulation of ruffle assembly (GO:1900027)2.87828507
74atrioventricular valve morphogenesis (GO:0003181)2.85519490
75regulation of keratinocyte proliferation (GO:0010837)2.83254735
76fatty-acyl-CoA metabolic process (GO:0035337)2.81783996
77collagen fibril organization (GO:0030199)2.79906886
78cellular response to antibiotic (GO:0071236)2.75137260
79mitotic G1 DNA damage checkpoint (GO:0031571)2.74956141
80bone trabecula formation (GO:0060346)2.74363683
81regulation of glomerulus development (GO:0090192)2.74330788
82extracellular fibril organization (GO:0043206)2.70131180
83cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.69253535
84positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.69176487
85polyol transport (GO:0015791)2.67165134
86epithelium development (GO:0060429)2.63569038
87positive regulation of monocyte chemotaxis (GO:0090026)2.63209498
88negative regulation of cell fate commitment (GO:0010454)2.62296363
89regulation of protein localization to cell surface (GO:2000008)2.62113896
90negative regulation of interleukin-17 production (GO:0032700)2.61728354
91alditol phosphate metabolic process (GO:0052646)2.61510330
92one-carbon compound transport (GO:0019755)2.60474983
93genitalia morphogenesis (GO:0035112)2.60315407
94myotube differentiation (GO:0014902)2.60092731
95hair cycle process (GO:0022405)2.57252771
96molting cycle process (GO:0022404)2.57252771
97establishment of planar polarity (GO:0001736)2.57169639
98establishment of tissue polarity (GO:0007164)2.57169639
99G1 DNA damage checkpoint (GO:0044783)2.56681057
100regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.54740817
101non-canonical Wnt signaling pathway (GO:0035567)2.54650415
102mitotic G1/S transition checkpoint (GO:0044819)2.50771403
103epithelial cell proliferation (GO:0050673)2.50451964
104secondary metabolite biosynthetic process (GO:0044550)2.49765131
105cytoskeletal anchoring at plasma membrane (GO:0007016)2.46768073
106positive regulation of T cell chemotaxis (GO:0010820)2.46553744
107regulation of T cell chemotaxis (GO:0010819)2.46553744
108sphingosine metabolic process (GO:0006670)2.45804546
109regulation of epidermis development (GO:0045682)2.44401427
110regulation of epidermal cell differentiation (GO:0045604)2.44037428
111collagen catabolic process (GO:0030574)2.43555029
112collagen metabolic process (GO:0032963)2.42457283
113arachidonic acid secretion (GO:0050482)2.41626504
114icosanoid secretion (GO:0032309)2.41626504
115defense response to fungus (GO:0050832)2.41445861
116ventricular cardiac muscle cell action potential (GO:0086005)2.40537284
117negative regulation of epidermal cell differentiation (GO:0045605)2.40083844
118sphingolipid biosynthetic process (GO:0030148)2.39721803
119prostate gland epithelium morphogenesis (GO:0060740)2.35679284
120negative regulation of keratinocyte proliferation (GO:0010839)2.35555442
121extracellular matrix disassembly (GO:0022617)2.35398434
122retina homeostasis (GO:0001895)2.34191704
123* epithelial cell differentiation (GO:0030855)2.32173960
124multicellular organismal macromolecule metabolic process (GO:0044259)2.31932497
125positive regulation of epidermal cell differentiation (GO:0045606)2.30545090
126negative regulation of stress fiber assembly (GO:0051497)2.29646050
127positive regulation of transforming growth factor beta production (GO:0071636)2.28780414
128eyelid development in camera-type eye (GO:0061029)2.28552548
129cell-cell junction assembly (GO:0007043)2.28337408
130smooth muscle tissue development (GO:0048745)2.27051404
131multicellular organismal catabolic process (GO:0044243)2.26842119
132cell-substrate junction assembly (GO:0007044)2.25344257
133acyl-CoA biosynthetic process (GO:0071616)2.24066712
134thioester biosynthetic process (GO:0035384)2.24066712
135detection of external biotic stimulus (GO:0098581)2.23406417
136morphogenesis of embryonic epithelium (GO:0016331)2.23357471
137fibril organization (GO:0097435)2.23178487
138prostaglandin biosynthetic process (GO:0001516)2.23005336
139regulation of interleukin-8 secretion (GO:2000482)2.21600705
140regulation of hair cycle (GO:0042634)2.21090232
141regulation of cardioblast differentiation (GO:0051890)2.20433336
142epithelial cell-cell adhesion (GO:0090136)2.19072900
143multicellular organismal metabolic process (GO:0044236)2.18056759
144cellular response to calcium ion (GO:0071277)2.17489540
145diol metabolic process (GO:0034311)2.15331878
146sphingoid metabolic process (GO:0046519)2.14995922
147plasma membrane repair (GO:0001778)2.12052101
148ephrin receptor signaling pathway (GO:0048013)2.10618570
149endodermal cell differentiation (GO:0035987)2.09876010
150myelination in peripheral nervous system (GO:0022011)2.07964810
151* regulation of water loss via skin (GO:0033561)19.1397221
152* multicellular organismal water homeostasis (GO:0050891)12.1412972
153desmosome organization (GO:0002934)11.4715038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.72909877
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.23932705
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.71786098
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.54085992
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.21996180
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.17767404
7FOXO3_23340844_ChIP-Seq_DLD1_Human2.09826939
8ZNF263_19887448_ChIP-Seq_K562_Human2.02791794
9TP63_17297297_ChIP-ChIP_HaCaT_Human10.8028735
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83782481
11TP53_18474530_ChIP-ChIP_U2OS_Human1.74968510
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.74338728
13TP63_23658742_ChIP-Seq_EP156T_Human1.73691914
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71439906
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68096894
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66831450
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66831450
18AR_21572438_ChIP-Seq_LNCaP_Human1.58039554
19* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.57322719
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55983710
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52178728
22RXR_22108803_ChIP-Seq_LS180_Human1.48968895
23TP63_22573176_ChIP-Seq_HFKS_Human1.47216815
24BCAT_22108803_ChIP-Seq_LS180_Human1.46232820
25* GATA6_21074721_ChIP-Seq_CACO-2_Human1.45088688
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44986870
27CJUN_26792858_Chip-Seq_BT549_Human1.39429427
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38009804
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37470174
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35325338
31TP53_16413492_ChIP-PET_HCT116_Human1.32070470
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29830670
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.29818625
34EGR1_19032775_ChIP-ChIP_M12_Human1.28206206
35CTCF_27219007_Chip-Seq_Bcells_Human1.27242060
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25338745
37* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24622312
38KLF5_25053715_ChIP-Seq_YYC3_Human1.23509823
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22619185
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22619185
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.21557795
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.21428414
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.19200817
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.19069288
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15401368
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15401368
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14603971
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.14450560
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14321718
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14109983
51CEBPB_22108803_ChIP-Seq_LS180_Human1.13654692
52SOX2_20726797_ChIP-Seq_SW620_Human1.12856717
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12444026
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.12399697
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11169666
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09980469
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08184852
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08005865
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07467703
60CTCF_20526341_ChIP-Seq_ESCs_Human1.06631579
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06423950
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05315120
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05178081
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04643072
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.03855510
66RACK7_27058665_Chip-Seq_MCF-7_Human1.03341478
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02010595
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.01588810
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00929810
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99253088
71ATF3_27146783_Chip-Seq_COLON_Human0.99096201
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98774970
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98518117
74TCF4_22108803_ChIP-Seq_LS180_Human0.96966038
75ARNT_22903824_ChIP-Seq_MCF-7_Human0.95976564
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95902329
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94914074
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93786362
79E2F1_20622854_ChIP-Seq_HELA_Human0.93700269
80JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93386065
81ERG_20517297_ChIP-Seq_VCAP_Human0.93286832
82* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92960575
83BCOR_27268052_Chip-Seq_Bcells_Human0.92445240
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92314959
85* HNFA_21074721_ChIP-Seq_CACO-2_Human0.92213508
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92088369
87P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91688021
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91451170
89AHR_22903824_ChIP-Seq_MCF-7_Human0.91328866
90OCT1_27270436_Chip-Seq_PROSTATE_Human0.90921540
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90512440
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90376677
93TBX20_22080862_ChIP-Seq_HEART_Mouse0.89134416
94TBX20_22328084_ChIP-Seq_HEART_Mouse0.89134416
95GATA6_25053715_ChIP-Seq_YYC3_Human0.89054056
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.88728902
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.87995395
98* RBPJ_21746931_ChIP-Seq_IB4_Human0.87760834
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87401083
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86865786
101LXR_22292898_ChIP-Seq_THP-1_Human0.86719218
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86678392
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85632580
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84944382
105KDM2B_26808549_Chip-Seq_K562_Human0.84798170
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.84410018
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84127083
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83783622
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83596755
110GATA4_25053715_ChIP-Seq_YYC3_Human0.83360459
111MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.82020180
112TAF2_19829295_ChIP-Seq_ESCs_Human0.81088534
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.80895928
114RING1B_27294783_Chip-Seq_ESCs_Mouse0.80835939
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.79314062
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78953853
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.77407274
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77323965
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77269829
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76346769
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.76056847
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75589920
123VDR_22108803_ChIP-Seq_LS180_Human0.75178525
124SA1_27219007_Chip-Seq_ERYTHROID_Human0.75020012
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74983614
126DROSHA_22980978_ChIP-Seq_HELA_Human0.73932762
127SMAD4_21741376_ChIP-Seq_ESCs_Human0.73159787
128CDX2_22108803_ChIP-Seq_LS180_Human0.72608781
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.72504302
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.70877166
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69747181
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68957325
133SMAD4_21799915_ChIP-Seq_A2780_Human0.68491614
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.67996689
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.67734074
136CLOCK_20551151_ChIP-Seq_293T_Human0.65399188
137GATA2_19941826_ChIP-Seq_K562_Human0.65313581
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.64858045
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62744904
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62197618
141ZFP57_27257070_Chip-Seq_ESCs_Mouse0.60190247
142PPARA_22158963_ChIP-Seq_LIVER_Mouse0.59328760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier7.89115206
2MP0005275_abnormal_skin_tensile7.73627680
3MP0009379_abnormal_foot_pigmentation4.78371549
4* MP0005501_abnormal_skin_physiology4.76353855
5MP0003941_abnormal_skin_development4.65702724
6MP0010234_abnormal_vibrissa_follicle4.51395553
7MP0000579_abnormal_nail_morphology4.39492992
8MP0005451_abnormal_body_composition4.11498945
9MP0002060_abnormal_skin_morphology3.68125498
10MP0003705_abnormal_hypodermis_morpholog3.34090252
11* MP0001216_abnormal_epidermal_layer3.02718251
12* MP0010771_integument_phenotype2.97211410
13MP0001188_hyperpigmentation2.93551349
14* MP0004947_skin_inflammation2.80871909
15MP0003191_abnormal_cellular_cholesterol2.65707992
16MP0002254_reproductive_system_inflammat2.59501187
17MP0000647_abnormal_sebaceous_gland2.55887701
18MP0008438_abnormal_cutaneous_collagen2.54295480
19MP0004381_abnormal_hair_follicle2.52120620
20MP0010678_abnormal_skin_adnexa2.51884986
21MP0000427_abnormal_hair_cycle2.34616273
22MP0000383_abnormal_hair_follicle2.33517532
23MP0002098_abnormal_vibrissa_morphology2.12245251
24MP0000377_abnormal_hair_follicle2.00679604
25MP0005171_absent_coat_pigmentation1.95550655
26MP0001243_abnormal_dermal_layer1.84537009
27* MP0009931_abnormal_skin_appearance1.78097506
28MP0003453_abnormal_keratinocyte_physiol1.74916678
29MP0002095_abnormal_skin_pigmentation1.60963573
30MP0004185_abnormal_adipocyte_glucose1.60409706
31MP0001191_abnormal_skin_condition1.56082152
32MP0000569_abnormal_digit_pigmentation1.48545159
33MP0005174_abnormal_tail_pigmentation1.44115126
34MP0003011_delayed_dark_adaptation1.43995842
35MP0000372_irregular_coat_pigmentation1.43184866
36MP0000467_abnormal_esophagus_morphology1.38587194
37MP0005377_hearing/vestibular/ear_phenot1.36186342
38MP0003878_abnormal_ear_physiology1.36186342
39MP0000762_abnormal_tongue_morphology1.33675798
40MP0004782_abnormal_surfactant_physiolog1.30718081
41MP0005075_abnormal_melanosome_morpholog1.29166949
42MP0004885_abnormal_endolymph1.26942531
43MP0000015_abnormal_ear_pigmentation1.22456272
44MP0003566_abnormal_cell_adhesion1.18509821
45MP0000367_abnormal_coat/_hair1.16512069
46MP0009780_abnormal_chondrocyte_physiolo1.04153340
47MP0010352_gastrointestinal_tract_polyps1.01759352
48MP0005408_hypopigmentation0.95561208
49MP0010030_abnormal_orbit_morphology0.95519587
50MP0002234_abnormal_pharynx_morphology0.90600041
51MP0003136_yellow_coat_color0.87192416
52MP0005503_abnormal_tendon_morphology0.83885838
53MP0001346_abnormal_lacrimal_gland0.80741681
54MP0001851_eye_inflammation0.79492723
55MP0001984_abnormal_olfaction0.77521946
56MP0005409_darkened_coat_color0.76402842
57MP0001340_abnormal_eyelid_morphology0.76361939
58MP0000371_diluted_coat_color0.76076952
59MP0000465_gastrointestinal_hemorrhage0.73927939
60MP0008961_abnormal_basal_metabolism0.72401813
61* MP0001784_abnormal_fluid_regulation0.68902846
62MP0003950_abnormal_plasma_membrane0.67756151
63MP0006054_spinal_hemorrhage0.64307967
64MP0000566_synostosis0.63626106
65MP0001186_pigmentation_phenotype0.63105447
66* MP0002177_abnormal_outer_ear0.62910091
67MP0005257_abnormal_intraocular_pressure0.62647397
68MP0001177_atelectasis0.60558575
69MP0004264_abnormal_extraembryonic_tissu0.57612150
70MP0001958_emphysema0.57350926
71MP0001849_ear_inflammation0.56642963
72MP0003763_abnormal_thymus_physiology0.53483355
73MP0002075_abnormal_coat/hair_pigmentati0.47959005
74MP0002009_preneoplasia0.47567261
75MP0009672_abnormal_birth_weight0.46570057
76MP0005666_abnormal_adipose_tissue0.44663028
77MP0002249_abnormal_larynx_morphology0.40887618
78MP0005076_abnormal_cell_differentiation0.39074138
79MP0005023_abnormal_wound_healing0.37642579
80MP0000432_abnormal_head_morphology0.37544828
81MP0002282_abnormal_trachea_morphology0.37481490
82MP0000428_abnormal_craniofacial_morphol0.37208326
83MP0005375_adipose_tissue_phenotype0.37103546
84MP0009384_cardiac_valve_regurgitation0.36554039
85MP0000013_abnormal_adipose_tissue0.35988257
86MP0002896_abnormal_bone_mineralization0.35815451
87MP0001299_abnormal_eye_distance/0.34828569
88MP0003329_amyloid_beta_deposits0.33203194
89MP0002108_abnormal_muscle_morphology0.32077479
90MP0003755_abnormal_palate_morphology0.31496545
91MP0005508_abnormal_skeleton_morphology0.30566229
92MP0002133_abnormal_respiratory_system0.30551893
93MP0005388_respiratory_system_phenotype0.30551893
94MP0002111_abnormal_tail_morphology0.30363665
95MP0002166_altered_tumor_susceptibility0.29634719
96MP0004272_abnormal_basement_membrane0.29539435
97MP0005197_abnormal_uvea_morphology0.28865546
98MP0009053_abnormal_anal_canal0.28137765
99MP0000462_abnormal_digestive_system0.28076693
100MP0006138_congestive_heart_failure0.27247862
101MP0003385_abnormal_body_wall0.27202287
102MP0008789_abnormal_olfactory_epithelium0.27154299
103MP0000751_myopathy0.26514407
104MP0002697_abnormal_eye_size0.25853911
105MP0002006_tumorigenesis0.24916453
106MP0005499_abnormal_olfactory_system0.24387694
107MP0005394_taste/olfaction_phenotype0.24387694
108MP0002877_abnormal_melanocyte_morpholog0.24082137
109MP0002090_abnormal_vision0.24050052
110MP0002109_abnormal_limb_morphology0.23610310
111MP0005647_abnormal_sex_gland0.23326123
112MP0003828_pulmonary_edema0.20958348
113MP0000627_abnormal_mammary_gland0.20946578
114MP0003638_abnormal_response/metabolism_0.20781544
115MP0005193_abnormal_anterior_eye0.20333329
116MP0000538_abnormal_urinary_bladder0.19197460
117MP0002998_abnormal_bone_remodeling0.18090463
118MP0001324_abnormal_eye_pigmentation0.17324146
119MP0001756_abnormal_urination0.15646123
120MP0004197_abnormal_fetal_growth/weight/0.15623590
121MP0004742_abnormal_vestibular_system0.15323954
122MP0003279_aneurysm0.14770624
123MP0009250_abnormal_appendicular_skeleto0.14262003
124MP0000747_muscle_weakness0.14176359
125MP0004858_abnormal_nervous_system0.14096154
126MP0002233_abnormal_nose_morphology0.13956211
127MP0003045_fibrosis0.12412228
128MP0000003_abnormal_adipose_tissue0.12152920
129MP0000733_abnormal_muscle_development0.11836941
130MP0005248_abnormal_Harderian_gland0.10991611
131MP0010368_abnormal_lymphatic_system0.09841718

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)8.43312875
2Conjunctival hamartoma (HP:0100780)7.83061040
3Abnormality of nail color (HP:0100643)7.34069658
4Abnormality of secondary sexual hair (HP:0009888)6.84824684
5Abnormality of the axillary hair (HP:0100134)6.84824684
6Hypotrichosis (HP:0001006)6.84772286
7Palmoplantar hyperkeratosis (HP:0000972)6.59906813
8Erythroderma (HP:0001019)6.54862677
9Erythema (HP:0010783)6.28367700
10Palmar hyperkeratosis (HP:0010765)6.26612133
11Plantar hyperkeratosis (HP:0007556)6.17969365
12Gangrene (HP:0100758)5.92150275
13Pili torti (HP:0003777)5.39196121
14Woolly hair (HP:0002224)5.35393673
15Onycholysis (HP:0001806)5.33411579
16Hamartoma of the eye (HP:0010568)5.05803536
17Right ventricular cardiomyopathy (HP:0011663)4.75086878
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.73146656
19Alopecia of scalp (HP:0002293)4.58103192
20Atrophic scars (HP:0001075)4.57562740
21Milia (HP:0001056)4.47025850
22Follicular hyperkeratosis (HP:0007502)4.44494116
23Ectropion (HP:0000656)4.27852525
24Abnormal blistering of the skin (HP:0008066)4.19364262
25Corneal erosion (HP:0200020)4.04411052
26Thick nail (HP:0001805)4.03213201
27Fragile skin (HP:0001030)3.80715432
28Fragile nails (HP:0001808)3.79720791
29Abnormality of the salivary glands (HP:0010286)3.65300783
30Lack of skin elasticity (HP:0100679)3.56918918
31Palmoplantar keratoderma (HP:0000982)3.56711949
32Abnormal hair laboratory examination (HP:0003328)3.55550747
33Nail dystrophy (HP:0008404)3.46314723
34Hypergammaglobulinemia (HP:0010702)3.30843625
35Increased connective tissue (HP:0009025)3.30018751
36Pruritus (HP:0000989)3.28002624
37Hypohidrosis (HP:0000966)3.26620131
38Type 1 muscle fiber predominance (HP:0003803)3.25072721
39Absent eyelashes (HP:0000561)3.18623206
40Premature rupture of membranes (HP:0001788)3.02377677
41Hyporeflexia of lower limbs (HP:0002600)3.01091707
42Curly hair (HP:0002212)3.00052380
43Advanced eruption of teeth (HP:0006288)2.81399652
44Split foot (HP:0001839)2.80436650
45Natal tooth (HP:0000695)2.75166701
46Hypoplastic labia majora (HP:0000059)2.71658257
47Absent hair (HP:0002298)2.71151483
48Nasolacrimal duct obstruction (HP:0000579)2.62079866
49Selective tooth agenesis (HP:0001592)2.60514649
50Lip pit (HP:0100267)2.57234420
51Aplasia involving bones of the upper limbs (HP:0009823)2.51783052
52Aplasia of the phalanges of the hand (HP:0009802)2.51783052
53Aplasia involving bones of the extremities (HP:0009825)2.51783052
54Hamartoma (HP:0010566)2.51586966
55Ankle contracture (HP:0006466)2.49744617
56Abnormality of the labia majora (HP:0012881)2.48554226
57Conical tooth (HP:0000698)2.48094189
58Sparse eyelashes (HP:0000653)2.45219076
59Protrusio acetabuli (HP:0003179)2.43085682
60Ventricular tachycardia (HP:0004756)2.41261597
61Abnormality of permanent molar morphology (HP:0011071)2.32659302
62Abnormality of the dental root (HP:0006486)2.32659302
63Taurodontia (HP:0000679)2.32659302
64Parakeratosis (HP:0001036)2.31657115
65Malignant hyperthermia (HP:0002047)2.30765982
66Slender build (HP:0001533)2.30574821
67Xerostomia (HP:0000217)2.30120782
68Duplicated collecting system (HP:0000081)2.27678581
69Depressed nasal tip (HP:0000437)2.27185699
70Melanocytic nevus (HP:0000995)2.23607208
71Abnormality of molar (HP:0011077)2.22307000
72Abnormality of molar morphology (HP:0011070)2.22307000
73Distal lower limb muscle weakness (HP:0009053)2.17307906
74Oligodontia (HP:0000677)2.17189602
75Pustule (HP:0200039)2.13830743
76Septate vagina (HP:0001153)2.13371035
77Severe Myopia (HP:0011003)2.11989779
78Abnormality of the lacrimal duct (HP:0011481)2.08373846
79Abnormality of the dental pulp (HP:0006479)2.07214370
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.07006451
81Osteolytic defects of the hand bones (HP:0009699)2.07006451
82Dehydration (HP:0001944)2.05921045
83Soft skin (HP:0000977)2.03647732
84Blue irides (HP:0000635)2.03506831
85Slow-growing hair (HP:0002217)2.03125662
86Abnormality of hair growth rate (HP:0011363)2.03125662
87Peritonitis (HP:0002586)2.00881803
88Increased IgE level (HP:0003212)11.0407309
89Cerebral aneurysm (HP:0004944)1.97696160
90Mildly elevated creatine phosphokinase (HP:0008180)1.96234360
91Hyperhidrosis (HP:0000975)1.94425851
92Furrowed tongue (HP:0000221)1.94151906
93Sensory axonal neuropathy (HP:0003390)1.93904939
94Mitral valve prolapse (HP:0001634)1.93512946
95Abnormality of the renal collecting system (HP:0004742)1.92740602
96Aortic dissection (HP:0002647)1.92634301
97Neonatal death (HP:0003811)1.90749276
98Acanthosis nigricans (HP:0000956)1.90569499
99Sparse scalp hair (HP:0002209)1.88528732
100Blepharitis (HP:0000498)1.87621350
101Brittle hair (HP:0002299)1.87049029
102Ridged nail (HP:0001807)1.86819241
103Abnormality of the nasolacrimal system (HP:0000614)1.85937833
104Skin ulcer (HP:0200042)1.85322164
105Ankyloglossia (HP:0010296)1.84525462
106Spinal rigidity (HP:0003306)1.84065511
107Papilloma (HP:0012740)1.80693288
108Verrucae (HP:0200043)1.80693288
109Achilles tendon contracture (HP:0001771)1.78392264
110Sepsis (HP:0100806)1.78142946
111Dilatation of the ascending aorta (HP:0005111)1.76335713
112Bladder diverticulum (HP:0000015)1.74692881
113Increased variability in muscle fiber diameter (HP:0003557)1.74679478
114Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.73079628
115Generalized hypopigmentation of hair (HP:0011358)1.72416672
116Areflexia of lower limbs (HP:0002522)1.70097032
117Dry skin (HP:0000958)1.69264977
118Distal lower limb amyotrophy (HP:0008944)1.65784017
119Anhidrosis (HP:0000970)1.64970534
120Abnormality of the Achilles tendon (HP:0005109)1.64891138
121Ventricular fibrillation (HP:0001663)1.62560628
122Oral leukoplakia (HP:0002745)1.61301943
123Labial hypoplasia (HP:0000066)1.60217134
124Recurrent corneal erosions (HP:0000495)1.56388194
125Breast hypoplasia (HP:0003187)1.56318676
126Generalized hypopigmentation (HP:0007513)1.56294490
127Coarse hair (HP:0002208)1.55288258
128Venous insufficiency (HP:0005293)1.55267591
129Thin skin (HP:0000963)1.54402720
130Laryngomalacia (HP:0001601)1.53566868
131Absent hand (HP:0004050)1.53021055
132Abnormality of skeletal muscle fiber size (HP:0012084)1.52949424
133Anonychia (HP:0001798)1.51926297
134Round ear (HP:0100830)1.51457489
135Hypoplasia of dental enamel (HP:0006297)1.50727075
136Venous abnormality (HP:0002624)1.49840436
137Neonatal short-limb short stature (HP:0008921)1.49752654
138Shallow orbits (HP:0000586)1.45454593
139Broad metatarsal (HP:0001783)1.43659804
140Congenital, generalized hypertrichosis (HP:0004540)1.42497605
141Striae distensae (HP:0001065)1.42043978
142Abnormality of the gastric mucosa (HP:0004295)1.40857759
143Down-sloping shoulders (HP:0200021)1.39069232
144Everted lower lip vermilion (HP:0000232)1.37627583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR15.66029324
2FER4.30457608
3MAPKAPK33.85724642
4MST1R3.80054086
5LATS13.29666963
6TIE12.75356962
7RIPK12.71731993
8MAP3K22.51393011
9MAP3K32.19250356
10ERN12.15534403
11NTRK22.14200013
12MAP3K92.07840363
13EPHB22.05441384
14TTN1.97958102
15MAP3K71.96842334
16FGFR21.90829264
17TRIB31.88694675
18PIK3CG1.80952693
19LATS21.77267456
20SIK11.75513712
21TAOK11.63614367
22MAP3K111.62310434
23EPHA31.61927204
24MST41.61791287
25SGK4941.53519819
26SGK2231.53519819
27SGK21.51199671
28OBSCN1.46345597
29BCR1.45666397
30TRPM71.44044415
31PBK1.37227331
32BMX1.36006340
33PTK61.34513970
34RPS6KB21.27049544
35MAP2K41.25217359
36DDR21.25075142
37RPS6KB11.24076808
38PRPF4B1.23135699
39FGR1.20432053
40PDGFRA1.19792232
41SGK31.19262638
42PAK31.16646814
43MARK21.15851466
44MAP3K11.14070785
45MET1.13629551
46EPHB11.12406880
47FGFR41.11704197
48CDK61.07101176
49MAP2K61.06818574
50CDK121.06416374
51PRKCH1.04548104
52STK111.01346761
53WNK10.98568447
54IKBKB0.97771514
55FGFR30.97316569
56NLK0.95587720
57MTOR0.95366807
58TYRO30.94493575
59EEF2K0.93911504
60MAPKAPK20.92636704
61MAPKAPK50.90631784
62EPHA20.90314489
63PTK20.88004152
64STK240.80322133
65ICK0.76522239
66MINK10.76435776
67KIT0.75377800
68PKN10.75200131
69AKT30.73152455
70STK380.72013690
71PRKD20.71939473
72TYK20.70267512
73* FGFR10.69764495
74IRAK10.69566335
75MAP2K30.69053663
76DYRK1B0.66387117
77PRKD10.65338501
78TGFBR20.64898805
79LMTK20.64883491
80MOS0.64396726
81PKN20.64212940
82LRRK20.63068481
83ERBB30.62551736
84MAP2K10.61945673
85CASK0.61797159
86GSK3A0.61583354
87PRKCI0.61232939
88CAMKK10.59977673
89ERBB40.59605182
90ITK0.57989485
91FRK0.57543597
92CSNK1A1L0.57005861
93ERBB20.56438301
94STK30.56302627
95STK38L0.55830039
96MAP3K60.54944215
97EPHA40.54078253
98CAMK1D0.53937055
99MAPK120.53621625
100CSNK1D0.49513679
101PDGFRB0.48784288
102GRK70.48061275
103CHUK0.47194911
104RPS6KA20.45890151
105MAP3K120.44225172
106MAPK110.44207419
107IRAK20.43299432
108SRPK10.41409635
109CDK30.40760986
110ROCK10.40057891
111BMPR20.38693764
112STK100.37756349
113ABL20.37556482
114SRC0.36452981
115BRD40.35607154
116FYN0.34102163
117JAK10.33244930
118MARK30.33044250
119GRK50.33015786
120BLK0.32151857
121CAMK1G0.30251790
122PAK20.28651159
123ADRBK10.28634435
124ROCK20.28144392
125RPS6KA10.27807198
126MAPK90.27212629
127ABL10.26939735
128PHKG10.26912239
129PHKG20.26912239
130IKBKE0.26576166
131MAPK40.26074046
132MAPK70.25137380
133SGK10.24998670
134MELK0.24105715
135MAP3K140.23250360
136HIPK20.23177904
137PRKCE0.22476401
138RET0.22476275
139CAMK40.21794623
140PRKAA20.21504355
141PIM20.20697979
142MAPK10.19556958
143ILK0.18848781
144GRK60.18679031

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.10398980
2ABC transporters_Homo sapiens_hsa020102.58961906
3ECM-receptor interaction_Homo sapiens_hsa045122.47503574
4Protein digestion and absorption_Homo sapiens_hsa049742.41971804
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32674088
6Linoleic acid metabolism_Homo sapiens_hsa005912.28028904
7Sphingolipid metabolism_Homo sapiens_hsa006002.26614183
8Basal cell carcinoma_Homo sapiens_hsa052172.09729335
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79045248
10Ovarian steroidogenesis_Homo sapiens_hsa049131.66085350
11Arachidonic acid metabolism_Homo sapiens_hsa005901.64701839
12Phototransduction_Homo sapiens_hsa047441.63875148
13GnRH signaling pathway_Homo sapiens_hsa049121.56187040
14Histidine metabolism_Homo sapiens_hsa003401.56157726
15Staphylococcus aureus infection_Homo sapiens_hsa051501.52487741
16Axon guidance_Homo sapiens_hsa043601.48131957
17Amoebiasis_Homo sapiens_hsa051461.45367382
18Steroid biosynthesis_Homo sapiens_hsa001001.44994092
19Tight junction_Homo sapiens_hsa045301.43329046
20Ether lipid metabolism_Homo sapiens_hsa005651.42861804
21Adherens junction_Homo sapiens_hsa045201.41176268
22Melanogenesis_Homo sapiens_hsa049161.40090109
23Hedgehog signaling pathway_Homo sapiens_hsa043401.39462664
24Long-term potentiation_Homo sapiens_hsa047201.38753401
25Renin secretion_Homo sapiens_hsa049241.33653120
26Choline metabolism in cancer_Homo sapiens_hsa052311.33520562
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31316746
28Proteoglycans in cancer_Homo sapiens_hsa052051.26928795
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.22614274
30Fat digestion and absorption_Homo sapiens_hsa049751.16852522
31Glioma_Homo sapiens_hsa052141.15392133
32VEGF signaling pathway_Homo sapiens_hsa043701.14716322
33Gastric acid secretion_Homo sapiens_hsa049711.14157840
34Hippo signaling pathway_Homo sapiens_hsa043901.11917205
35Dorso-ventral axis formation_Homo sapiens_hsa043201.10352626
36Phenylalanine metabolism_Homo sapiens_hsa003601.09674783
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.09118716
38Focal adhesion_Homo sapiens_hsa045101.08597166
39ErbB signaling pathway_Homo sapiens_hsa040121.08394722
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06962303
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00360084
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.99723229
43Platelet activation_Homo sapiens_hsa046110.98612248
44Retinol metabolism_Homo sapiens_hsa008300.94436297
45Fatty acid biosynthesis_Homo sapiens_hsa000610.94030472
46Thyroid cancer_Homo sapiens_hsa052160.92550073
47Inositol phosphate metabolism_Homo sapiens_hsa005620.92444841
48Small cell lung cancer_Homo sapiens_hsa052220.89643960
49Ras signaling pathway_Homo sapiens_hsa040140.89638972
50Long-term depression_Homo sapiens_hsa047300.88530621
51Pertussis_Homo sapiens_hsa051330.86860880
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.86808514
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.86331060
54Salivary secretion_Homo sapiens_hsa049700.86152705
55Estrogen signaling pathway_Homo sapiens_hsa049150.85934045
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85573462
57Olfactory transduction_Homo sapiens_hsa047400.85227959
58Rap1 signaling pathway_Homo sapiens_hsa040150.83949693
59MicroRNAs in cancer_Homo sapiens_hsa052060.80260564
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.78875408
61Insulin resistance_Homo sapiens_hsa049310.78443647
62Oxytocin signaling pathway_Homo sapiens_hsa049210.78069345
63Wnt signaling pathway_Homo sapiens_hsa043100.75820949
64p53 signaling pathway_Homo sapiens_hsa041150.75395505
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74650785
66Malaria_Homo sapiens_hsa051440.74599323
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71763512
68PPAR signaling pathway_Homo sapiens_hsa033200.71724685
69Toxoplasmosis_Homo sapiens_hsa051450.71257846
70Glutamatergic synapse_Homo sapiens_hsa047240.69537455
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69438350
72Serotonergic synapse_Homo sapiens_hsa047260.67892708
73Notch signaling pathway_Homo sapiens_hsa043300.66507539
74Circadian entrainment_Homo sapiens_hsa047130.65316569
75Insulin signaling pathway_Homo sapiens_hsa049100.63767173
76Tuberculosis_Homo sapiens_hsa051520.63720139
77Acute myeloid leukemia_Homo sapiens_hsa052210.63499553
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.60443145
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58025268
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56367156
81mTOR signaling pathway_Homo sapiens_hsa041500.56217313
82Renal cell carcinoma_Homo sapiens_hsa052110.53892223
83Tyrosine metabolism_Homo sapiens_hsa003500.53736843
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53493187
85Pancreatic secretion_Homo sapiens_hsa049720.53278987
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53248530
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52580724
88Hepatitis C_Homo sapiens_hsa051600.51552651
89Calcium signaling pathway_Homo sapiens_hsa040200.51536040
90Dilated cardiomyopathy_Homo sapiens_hsa054140.50566201
91Bladder cancer_Homo sapiens_hsa052190.48822952
92Pancreatic cancer_Homo sapiens_hsa052120.48735480
93Endocytosis_Homo sapiens_hsa041440.48589015
94MAPK signaling pathway_Homo sapiens_hsa040100.47682939
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46631423
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45937603
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45811075
98Amphetamine addiction_Homo sapiens_hsa050310.45781856
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45494319
100Collecting duct acid secretion_Homo sapiens_hsa049660.44976537
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44123835
102Pathways in cancer_Homo sapiens_hsa052000.43406672
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.43093135
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43058862
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42992669
106cAMP signaling pathway_Homo sapiens_hsa040240.42883252
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42808355
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42756665
109Dopaminergic synapse_Homo sapiens_hsa047280.42406227
110Circadian rhythm_Homo sapiens_hsa047100.41989892
111Gap junction_Homo sapiens_hsa045400.41866927
112Glucagon signaling pathway_Homo sapiens_hsa049220.41602238
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41450441
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41171282
115TGF-beta signaling pathway_Homo sapiens_hsa043500.39939837
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39380666
117Fatty acid metabolism_Homo sapiens_hsa012120.39276605
118FoxO signaling pathway_Homo sapiens_hsa040680.38787894
119Endometrial cancer_Homo sapiens_hsa052130.36029154
120Oocyte meiosis_Homo sapiens_hsa041140.30757192
121Prostate cancer_Homo sapiens_hsa052150.29982687
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.29853064

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