FLG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transforming growth factor beta1 production (GO:0032908)8.96549711
2positive regulation of glomerulus development (GO:0090193)8.78211420
3* water homeostasis (GO:0030104)8.67552971
4keratinocyte differentiation (GO:0030216)7.82845288
5detection of bacterium (GO:0016045)7.73936649
6regulation of cell proliferation involved in kidney development (GO:1901722)7.36823078
7keratinocyte proliferation (GO:0043616)7.20315079
8peptide cross-linking (GO:0018149)7.09032590
9surfactant homeostasis (GO:0043129)6.80319691
10detection of other organism (GO:0098543)6.66853866
11long-chain fatty acid biosynthetic process (GO:0042759)6.37998661
12epidermal cell differentiation (GO:0009913)6.36355875
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.29182489
14chemical homeostasis within a tissue (GO:0048875)6.27734750
15phospholipid efflux (GO:0033700)6.24710084
16fatty acid elongation (GO:0030497)6.20796911
17hemidesmosome assembly (GO:0031581)6.09018947
18phosphatidylinositol acyl-chain remodeling (GO:0036149)6.08596900
19positive regulation of interleukin-8 secretion (GO:2000484)5.92563551
20phosphatidylserine acyl-chain remodeling (GO:0036150)5.89827909
21hair cycle (GO:0042633)5.83235152
22molting cycle (GO:0042303)5.83235152
23regulation of glomerulus development (GO:0090192)5.69711035
24positive regulation of cholesterol efflux (GO:0010875)5.64521746
25lateral sprouting from an epithelium (GO:0060601)5.54526969
26skin morphogenesis (GO:0043589)4.98737140
27positive regulation of transforming growth factor beta production (GO:0071636)4.97126066
28keratinocyte development (GO:0003334)4.96649590
29positive regulation of sterol transport (GO:0032373)4.96404148
30positive regulation of cholesterol transport (GO:0032376)4.96404148
31epithelial cell differentiation involved in prostate gland development (GO:0060742)4.91068933
32epidermis development (GO:0008544)4.77317067
33polarized epithelial cell differentiation (GO:0030859)4.76316614
34regulation of natural killer cell differentiation (GO:0032823)4.65786709
35phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.62379400
36bundle of His cell to Purkinje myocyte communication (GO:0086069)4.58934575
37linoleic acid metabolic process (GO:0043651)4.55014623
38phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.44282623
39hormone catabolic process (GO:0042447)4.28892679
40lipoxygenase pathway (GO:0019372)4.15071401
41hair follicle morphogenesis (GO:0031069)4.10569588
42regulation of ruffle assembly (GO:1900027)4.09286912
43phosphatidylcholine acyl-chain remodeling (GO:0036151)4.08055836
44regulation of interleukin-8 secretion (GO:2000482)3.99860579
45regulation of cholesterol efflux (GO:0010874)3.95774220
46glutathione biosynthetic process (GO:0006750)3.87631968
47G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.79229981
48intermediate filament organization (GO:0045109)3.72865798
49regulation of keratinocyte differentiation (GO:0045616)3.72371218
50epithelium development (GO:0060429)3.72182486
51skin development (GO:0043588)3.69006242
52regulation of protein localization to cell surface (GO:2000008)3.62011147
53phosphatidylserine metabolic process (GO:0006658)3.59333234
54nonribosomal peptide biosynthetic process (GO:0019184)3.53420420
55long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.42357876
56phospholipid catabolic process (GO:0009395)3.40459412
57positive regulation of collagen biosynthetic process (GO:0032967)3.39212674
58regulation of transforming growth factor beta production (GO:0071634)3.37860944
59sphingosine metabolic process (GO:0006670)3.33077546
60virion attachment to host cell (GO:0019062)3.32220370
61adhesion of symbiont to host cell (GO:0044650)3.32220370
62long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.31943825
63purinergic nucleotide receptor signaling pathway (GO:0035590)3.28975887
64planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26367969
65positive regulation of collagen metabolic process (GO:0010714)3.25974026
66detection of external biotic stimulus (GO:0098581)3.24024697
67defense response to fungus (GO:0050832)3.21506612
68gap junction assembly (GO:0016264)3.18038095
69one-carbon compound transport (GO:0019755)3.17272757
70hair cycle process (GO:0022405)3.11199624
71molting cycle process (GO:0022404)3.11199624
72positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.09908664
73sphingoid metabolic process (GO:0046519)3.09850420
74ectoderm development (GO:0007398)3.07595305
75peptide catabolic process (GO:0043171)3.06787533
76fatty-acyl-CoA biosynthetic process (GO:0046949)3.04371447
77regulation of keratinocyte proliferation (GO:0010837)3.03752909
78regulation of collagen biosynthetic process (GO:0032965)2.97557428
79negative regulation of interferon-gamma production (GO:0032689)2.96072537
80cellular response to antibiotic (GO:0071236)2.95809739
81regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.91704232
82diol metabolic process (GO:0034311)2.91119252
83very long-chain fatty acid metabolic process (GO:0000038)2.91073486
84ventricular cardiac muscle cell action potential (GO:0086005)2.88834486
85alditol phosphate metabolic process (GO:0052646)2.87728660
86negative regulation of epidermal cell differentiation (GO:0045605)2.85409878
87fatty-acyl-CoA metabolic process (GO:0035337)2.82963895
88polyol transport (GO:0015791)2.77242466
89detection of biotic stimulus (GO:0009595)2.75762636
90intestinal epithelial cell development (GO:0060576)2.74958632
91retinol metabolic process (GO:0042572)2.72622226
92positive regulation of T-helper 1 type immune response (GO:0002827)2.71957390
93mitotic G1 DNA damage checkpoint (GO:0031571)2.67731845
94negative regulation of keratinocyte proliferation (GO:0010839)2.66535561
95genitalia morphogenesis (GO:0035112)2.66034050
96phospholipid scrambling (GO:0017121)2.64481657
97positive regulation of urine volume (GO:0035810)2.60615457
98beta-amyloid metabolic process (GO:0050435)2.60290012
99arachidonic acid secretion (GO:0050482)2.59024604
100icosanoid secretion (GO:0032309)2.59024604
101phosphatidylglycerol metabolic process (GO:0046471)2.58722405
102adhesion of symbiont to host (GO:0044406)2.58688511
103unsaturated fatty acid biosynthetic process (GO:0006636)2.57908889
104regulation of epidermal cell differentiation (GO:0045604)2.57760425
105epithelial cell proliferation (GO:0050673)2.56520665
106regulation of heart rate by cardiac conduction (GO:0086091)2.55273397
107dendritic cell migration (GO:0036336)2.53840235
108regulation of phospholipase A2 activity (GO:0032429)2.52868076
109establishment of planar polarity (GO:0001736)2.52533230
110establishment of tissue polarity (GO:0007164)2.52533230
111regulation of collagen metabolic process (GO:0010712)2.51806650
112cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.51428166
113positive regulation of monocyte chemotaxis (GO:0090026)2.50944301
114mitotic G1/S transition checkpoint (GO:0044819)2.47032685
115G1 DNA damage checkpoint (GO:0044783)2.46042660
116eyelid development in camera-type eye (GO:0061029)2.45707752
117intermediate filament-based process (GO:0045103)2.45425815
118response to phenylpropanoid (GO:0080184)2.45339200
119positive regulation of epidermal cell differentiation (GO:0045606)2.44725303
120plasma membrane repair (GO:0001778)2.44376774
121negative regulation of epidermis development (GO:0045683)2.44247450
122hair cell differentiation (GO:0035315)2.43324515
123prostaglandin biosynthetic process (GO:0001516)2.43215019
124prostanoid biosynthetic process (GO:0046457)2.43215019
125peptide biosynthetic process (GO:0043043)2.41643042
126intermediate filament cytoskeleton organization (GO:0045104)2.40771332
127purinergic receptor signaling pathway (GO:0035587)2.40428251
128regulation of epidermis development (GO:0045682)2.40063511
129prostate gland epithelium morphogenesis (GO:0060740)2.39375518
130negative regulation of adenylate cyclase activity (GO:0007194)2.39010932
131sympathetic nervous system development (GO:0048485)2.38651320
132epithelial cell-cell adhesion (GO:0090136)2.37857054
133epithelial cell differentiation (GO:0030855)2.37301155
134positive regulation of multicellular organismal metabolic process (GO:0044253)2.36051763
135negative regulation of cell aging (GO:0090344)2.36003751
136hair follicle development (GO:0001942)2.34684402
137regulation of T cell chemotaxis (GO:0010819)2.34039732
138positive regulation of T cell chemotaxis (GO:0010820)2.34039732
139ganglion development (GO:0061548)2.33429256
140imidazole-containing compound metabolic process (GO:0052803)2.32706941
141negative regulation of embryonic development (GO:0045992)2.31341923
142regulation of natural killer cell activation (GO:0032814)2.29713579
143centrosome localization (GO:0051642)2.29292798
144regulation of sterol transport (GO:0032371)2.28721338
145regulation of cholesterol transport (GO:0032374)2.28721338
146negative regulation of cell fate specification (GO:0009996)2.27501255
147regulation of cholesterol homeostasis (GO:2000188)2.26689925
148ceramide biosynthetic process (GO:0046513)2.26244066
149negative regulation of cyclase activity (GO:0031280)2.26061025
150smooth muscle tissue development (GO:0048745)2.25807675
151sphingolipid biosynthetic process (GO:0030148)2.24780271
152morphogenesis of embryonic epithelium (GO:0016331)2.23277430
153* establishment of skin barrier (GO:0061436)19.7772084
154* regulation of water loss via skin (GO:0033561)16.7082646
155keratinization (GO:0031424)13.9914777
156desmosome organization (GO:0002934)10.8504394
157* multicellular organismal water homeostasis (GO:0050891)10.5995889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.27719618
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.20935708
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.11438782
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.92131288
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.86190202
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.49377599
7FOXO3_23340844_ChIP-Seq_DLD1_Human2.42294953
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34789961
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.26448403
10TP53_18474530_ChIP-ChIP_U2OS_Human2.04091370
11TP63_17297297_ChIP-ChIP_HaCaT_Human10.0593809
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90551070
13AR_21572438_ChIP-Seq_LNCaP_Human1.82118109
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80951123
15ZNF263_19887448_ChIP-Seq_K562_Human1.74480632
16TP63_23658742_ChIP-Seq_EP156T_Human1.74192625
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72123926
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72123926
19TCF4_18268006_ChIP-ChIP_LS174T_Human1.60985905
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60228515
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.59915066
22BCAT_22108803_ChIP-Seq_LS180_Human1.54184050
23RXR_22108803_ChIP-Seq_LS180_Human1.48970277
24SOX2_20726797_ChIP-Seq_SW620_Human1.42919178
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40718461
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39294756
27CJUN_26792858_Chip-Seq_BT549_Human1.35996946
28EGR1_19032775_ChIP-ChIP_M12_Human1.33568356
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31864766
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.31714456
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31509201
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29857783
33CEBPB_22108803_ChIP-Seq_LS180_Human1.27971178
34* TP63_22573176_ChIP-Seq_HFKS_Human1.27572735
35TP53_16413492_ChIP-PET_HCT116_Human1.26136523
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24024069
37GATA3_24758297_ChIP-Seq_MCF-7_Human1.22061029
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21283517
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21018128
40* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.20830390
41KLF5_25053715_ChIP-Seq_YYC3_Human1.19814414
42UBF1/2_26484160_Chip-Seq_HMECs_Human1.17140458
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14674731
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12435661
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.12098310
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.10172164
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10039335
48TAF15_26573619_Chip-Seq_HEK293_Human1.09729993
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08764752
50ERG_20517297_ChIP-Seq_VCAP_Human1.08117389
51* GATA6_21074721_ChIP-Seq_CACO-2_Human1.07664077
52GATA4_25053715_ChIP-Seq_YYC3_Human1.05918345
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05151387
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04326963
55CTCF_27219007_Chip-Seq_Bcells_Human1.02063472
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00419660
57TCF4_22108803_ChIP-Seq_LS180_Human1.00409190
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98914346
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98900573
60JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97592130
61RNF2_27304074_Chip-Seq_ESCs_Mouse0.97229166
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96885117
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96356774
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95674142
65RACK7_27058665_Chip-Seq_MCF-7_Human0.95286622
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93958145
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93853308
68ARNT_22903824_ChIP-Seq_MCF-7_Human0.93633898
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93457020
70VDR_22108803_ChIP-Seq_LS180_Human0.92883219
71EZH2_27294783_Chip-Seq_ESCs_Mouse0.92461167
72AHR_22903824_ChIP-Seq_MCF-7_Human0.92417807
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90357335
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90019777
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89055399
76RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88423017
77EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88423017
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88264244
79HNFA_21074721_ChIP-Seq_CACO-2_Human0.88237213
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87382996
81CDX2_22108803_ChIP-Seq_LS180_Human0.87090653
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86669093
83SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86610614
84LXR_22158963_ChIP-Seq_LIVER_Mouse0.86562516
85FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86270215
86ATF3_27146783_Chip-Seq_COLON_Human0.85807957
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85286018
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85251055
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84897599
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84681224
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84633209
92EED_16625203_ChIP-ChIP_MESCs_Mouse0.84485586
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84213590
94SMAD4_21799915_ChIP-Seq_A2780_Human0.83966854
95LXR_22292898_ChIP-Seq_THP-1_Human0.83243221
96KDM2B_26808549_Chip-Seq_K562_Human0.82188742
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81391183
98* RBPJ_21746931_ChIP-Seq_IB4_Human0.81362205
99EZH2_27304074_Chip-Seq_ESCs_Mouse0.81308991
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80899332
101PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80282233
102AR_25329375_ChIP-Seq_VCAP_Human0.80103099
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.79794278
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.79250381
105P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.79232464
106ERA_21632823_ChIP-Seq_H3396_Human0.78958970
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78764472
108AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78707895
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.78609550
110OCT1_27270436_Chip-Seq_PROSTATE_Human0.78457804
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78124226
112TBL1_22424771_ChIP-Seq_293T_Human0.77846084
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77340262
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76533301
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76501022
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.76274696
117MTF2_20144788_ChIP-Seq_MESCs_Mouse0.76201102
118TAF2_19829295_ChIP-Seq_ESCs_Human0.75943000
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.75712645
120* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75688938
121P53_21459846_ChIP-Seq_SAOS-2_Human0.75635456
122MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.75118077
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74870252
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74870252
125CTCF_20526341_ChIP-Seq_ESCs_Human0.74528090
126BCOR_27268052_Chip-Seq_Bcells_Human0.72786792
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.71768683
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.71059272
129GATA6_25053715_ChIP-Seq_YYC3_Human0.69206988
130E2F1_20622854_ChIP-Seq_HELA_Human0.68696822
131PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.68692514
132SMAD4_21741376_ChIP-Seq_ESCs_Human0.67962630
133ETV1_20927104_ChIP-Seq_GIST48_Human0.66987916
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.66655787
135FOXA1_21572438_ChIP-Seq_LNCaP_Human0.66501647
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.66287758
137FUS_26573619_Chip-Seq_HEK293_Human0.65415851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.78612011
2MP0005275_abnormal_skin_tensile6.91005809
3MP0003941_abnormal_skin_development6.22223782
4MP0010234_abnormal_vibrissa_follicle5.75581892
5MP0005451_abnormal_body_composition5.29785608
6MP0005501_abnormal_skin_physiology5.16800127
7MP0009379_abnormal_foot_pigmentation3.83464356
8MP0003191_abnormal_cellular_cholesterol3.62353551
9MP0004947_skin_inflammation3.60452815
10MP0002060_abnormal_skin_morphology3.56488515
11MP0010771_integument_phenotype3.10963476
12MP0001216_abnormal_epidermal_layer3.08222513
13MP0002254_reproductive_system_inflammat2.84336134
14MP0010678_abnormal_skin_adnexa2.56339225
15MP0000579_abnormal_nail_morphology2.53028225
16MP0004381_abnormal_hair_follicle2.44516885
17MP0004185_abnormal_adipocyte_glucose2.21096222
18MP0003705_abnormal_hypodermis_morpholog2.01611833
19MP0000647_abnormal_sebaceous_gland1.93409614
20MP0000383_abnormal_hair_follicle1.89270901
21MP0009931_abnormal_skin_appearance1.87775273
22MP0004782_abnormal_surfactant_physiolog1.85464321
23MP0003453_abnormal_keratinocyte_physiol1.77607220
24MP0003011_delayed_dark_adaptation1.76889863
25MP0000427_abnormal_hair_cycle1.72806659
26MP0002098_abnormal_vibrissa_morphology1.70194538
27MP0008438_abnormal_cutaneous_collagen1.65935692
28MP0005377_hearing/vestibular/ear_phenot1.58290279
29MP0003878_abnormal_ear_physiology1.58290279
30MP0000377_abnormal_hair_follicle1.57648205
31MP0001191_abnormal_skin_condition1.55634981
32MP0005409_darkened_coat_color1.48842473
33MP0004885_abnormal_endolymph1.45513051
34MP0005075_abnormal_melanosome_morpholog1.40327125
35MP0008961_abnormal_basal_metabolism1.37613436
36MP0001243_abnormal_dermal_layer1.27753474
37MP0005171_absent_coat_pigmentation1.18861310
38MP0000467_abnormal_esophagus_morphology1.16594588
39MP0003950_abnormal_plasma_membrane1.11160112
40MP0000762_abnormal_tongue_morphology1.06109033
41MP0005174_abnormal_tail_pigmentation1.02585761
42MP0000465_gastrointestinal_hemorrhage1.00823539
43MP0000569_abnormal_digit_pigmentation1.00568098
44MP0000372_irregular_coat_pigmentation0.99896402
45MP0002009_preneoplasia0.94099885
46MP0000367_abnormal_coat/_hair0.92805422
47MP0003566_abnormal_cell_adhesion0.90479355
48MP0001984_abnormal_olfaction0.90149328
49MP0002177_abnormal_outer_ear0.89250575
50MP0001177_atelectasis0.80925120
51MP0003329_amyloid_beta_deposits0.74888283
52MP0001784_abnormal_fluid_regulation0.71331387
53MP0002095_abnormal_skin_pigmentation0.69655856
54MP0001340_abnormal_eyelid_morphology0.67715882
55MP0005666_abnormal_adipose_tissue0.66606311
56MP0000015_abnormal_ear_pigmentation0.63977822
57MP0001346_abnormal_lacrimal_gland0.63029503
58MP0009672_abnormal_birth_weight0.61317965
59MP0003763_abnormal_thymus_physiology0.60564947
60MP0009333_abnormal_splenocyte_physiolog0.60231332
61MP0001851_eye_inflammation0.59112119
62MP0006054_spinal_hemorrhage0.57848822
63MP0005257_abnormal_intraocular_pressure0.57253237
64MP0005375_adipose_tissue_phenotype0.51434767
65MP0000013_abnormal_adipose_tissue0.50761468
66MP0005408_hypopigmentation0.50598697
67MP0000566_synostosis0.49702077
68MP0003136_yellow_coat_color0.47346842
69MP0009384_cardiac_valve_regurgitation0.45913121
70MP0001186_pigmentation_phenotype0.45551108
71MP0010352_gastrointestinal_tract_polyps0.44521243
72MP0001299_abnormal_eye_distance/0.44467062
73MP0002166_altered_tumor_susceptibility0.43494956
74MP0004264_abnormal_extraembryonic_tissu0.42684436
75MP0008789_abnormal_olfactory_epithelium0.40229117
76MP0005076_abnormal_cell_differentiation0.40130642
77MP0000371_diluted_coat_color0.39632086
78MP0002006_tumorigenesis0.39377787
79MP0005647_abnormal_sex_gland0.38199193
80MP0000747_muscle_weakness0.38111738
81MP0003638_abnormal_response/metabolism_0.36198386
82MP0005023_abnormal_wound_healing0.35896562
83MP0002090_abnormal_vision0.35395060
84MP0000604_amyloidosis0.33955555
85MP0005499_abnormal_olfactory_system0.33448378
86MP0005394_taste/olfaction_phenotype0.33448378
87MP0001849_ear_inflammation0.32327943
88MP0010030_abnormal_orbit_morphology0.32273299
89MP0009053_abnormal_anal_canal0.30629193
90MP0001188_hyperpigmentation0.29719292
91MP0001958_emphysema0.29436716
92MP0002971_abnormal_brown_adipose0.28970133
93MP0002896_abnormal_bone_mineralization0.28736353
94MP0005503_abnormal_tendon_morphology0.28677350
95MP0005388_respiratory_system_phenotype0.28194234
96MP0002133_abnormal_respiratory_system0.28194234
97MP0000432_abnormal_head_morphology0.27985527
98MP0002075_abnormal_coat/hair_pigmentati0.27539180
99MP0000428_abnormal_craniofacial_morphol0.27406516
100MP0000627_abnormal_mammary_gland0.24276114
101MP0002234_abnormal_pharynx_morphology0.23935281
102MP0002108_abnormal_muscle_morphology0.23583101
103MP0000751_myopathy0.23446916
104MP0000685_abnormal_immune_system0.23419212
105MP0002111_abnormal_tail_morphology0.21523940
106MP0002877_abnormal_melanocyte_morpholog0.20559162
107MP0003632_abnormal_nervous_system0.19391810
108MP0002233_abnormal_nose_morphology0.19248474
109MP0004197_abnormal_fetal_growth/weight/0.19240032
110MP0005330_cardiomyopathy0.17691729
111MP0000462_abnormal_digestive_system0.17529115
112MP0005620_abnormal_muscle_contractility0.17309832
113MP0000003_abnormal_adipose_tissue0.16811233
114MP0005248_abnormal_Harderian_gland0.15760562
115MP0003075_altered_response_to0.15730439
116MP0000538_abnormal_urinary_bladder0.15547435
117MP0005508_abnormal_skeleton_morphology0.14758488
118MP0004272_abnormal_basement_membrane0.13999628
119MP0002282_abnormal_trachea_morphology0.13794420
120MP0009703_decreased_birth_body0.13261527
121MP0002109_abnormal_limb_morphology0.13189229
122MP0002249_abnormal_larynx_morphology0.12612892
123MP0001873_stomach_inflammation0.12369980
124MP0002118_abnormal_lipid_homeostasis0.11814787
125MP0006138_congestive_heart_failure0.11780841
126MP0001756_abnormal_urination0.11459282
127MP0009780_abnormal_chondrocyte_physiolo0.10707493
128MP0001485_abnormal_pinna_reflex0.10054668
129MP0000470_abnormal_stomach_morphology0.09084379
130MP0004087_abnormal_muscle_fiber0.08215244
131MP0002972_abnormal_cardiac_muscle0.07936067
132MP0004130_abnormal_muscle_cell0.07443200
133MP0003755_abnormal_palate_morphology0.07392671
134MP0005193_abnormal_anterior_eye0.07286979
135MP0002697_abnormal_eye_size0.07275428
136MP0000749_muscle_degeneration0.07044382

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.09995894
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.39497632
3Eczematoid dermatitis (HP:0000976)7.23735477
4Abnormality of nail color (HP:0100643)7.20685529
5Gangrene (HP:0100758)7.03724226
6Ectropion (HP:0000656)5.86269608
7Hypotrichosis (HP:0001006)5.83904440
8Erythroderma (HP:0001019)5.62327266
9Hyporeflexia of lower limbs (HP:0002600)5.12350438
10Lack of skin elasticity (HP:0100679)5.07813383
11Corneal erosion (HP:0200020)5.00294029
12Erythema (HP:0010783)4.98206298
13Plantar hyperkeratosis (HP:0007556)4.94592775
14Right ventricular cardiomyopathy (HP:0011663)4.91479964
15Palmoplantar hyperkeratosis (HP:0000972)4.77754795
16Woolly hair (HP:0002224)4.70106858
17Palmar hyperkeratosis (HP:0010765)4.47241783
18Onycholysis (HP:0001806)4.25582304
19Pruritus (HP:0000989)4.23658101
20Hypohidrosis (HP:0000966)4.05976013
21Fragile nails (HP:0001808)4.05434514
22Palmoplantar keratoderma (HP:0000982)3.96575178
23Lip pit (HP:0100267)3.93771435
24Parakeratosis (HP:0001036)3.87656548
25Curly hair (HP:0002212)3.84776041
26Conjunctival hamartoma (HP:0100780)3.77601149
27Atrophic scars (HP:0001075)3.67949468
28Milia (HP:0001056)3.66770799
29Malignant hyperthermia (HP:0002047)3.64339270
30Absent eyelashes (HP:0000561)3.54299714
31Sensory axonal neuropathy (HP:0003390)3.54145107
32Abnormal blistering of the skin (HP:0008066)3.48808218
33Thick nail (HP:0001805)3.41411482
34Areflexia of lower limbs (HP:0002522)3.40905845
35Pili torti (HP:0003777)3.35655734
36Increased connective tissue (HP:0009025)3.31401183
37Nail dystrophy (HP:0008404)3.29053157
38Dehydration (HP:0001944)3.26232692
39Alopecia of scalp (HP:0002293)3.17630590
40Absent hair (HP:0002298)3.03449914
41Fragile skin (HP:0001030)3.01761962
42Oral leukoplakia (HP:0002745)2.98968249
43Distal lower limb muscle weakness (HP:0009053)2.97427763
44Type 1 muscle fiber predominance (HP:0003803)2.92444816
45Sepsis (HP:0100806)2.88037687
46Abnormality of hair growth rate (HP:0011363)2.81414603
47Slow-growing hair (HP:0002217)2.81414603
48Split foot (HP:0001839)2.77733649
49Conical tooth (HP:0000698)2.68427605
50Acanthosis nigricans (HP:0000956)2.64229745
51Dry skin (HP:0000958)2.59223840
52Nasolacrimal duct obstruction (HP:0000579)2.58788018
53Melanocytic nevus (HP:0000995)2.57321418
54Ventricular tachycardia (HP:0004756)2.57025465
55Duplicated collecting system (HP:0000081)2.52612525
56Abnormality of the labia majora (HP:0012881)2.52249907
57Severe Myopia (HP:0011003)2.50965807
58Premature ovarian failure (HP:0008209)2.43176957
59Xerostomia (HP:0000217)2.40574193
60Sparse scalp hair (HP:0002209)2.40126241
61Advanced eruption of teeth (HP:0006288)2.39948284
62Hypergammaglobulinemia (HP:0010702)2.37556345
63Abnormality of permanent molar morphology (HP:0011071)2.36038032
64Abnormality of the dental root (HP:0006486)2.36038032
65Taurodontia (HP:0000679)2.36038032
66Follicular hyperkeratosis (HP:0007502)2.35808175
67Hamartoma (HP:0010566)2.34742845
68Natal tooth (HP:0000695)2.34195312
69Selective tooth agenesis (HP:0001592)2.32950834
70Aplasia involving bones of the upper limbs (HP:0009823)2.31690302
71Aplasia of the phalanges of the hand (HP:0009802)2.31690302
72Aplasia involving bones of the extremities (HP:0009825)2.31690302
73Depressed nasal tip (HP:0000437)2.31152799
74Hamartoma of the eye (HP:0010568)2.26208407
75Septate vagina (HP:0001153)2.22021934
76Abnormality of molar morphology (HP:0011070)2.21269820
77Abnormality of molar (HP:0011077)2.21269820
78Abnormality of the renal collecting system (HP:0004742)2.20642871
79Premature rupture of membranes (HP:0001788)2.12288626
80Abnormality of the dental pulp (HP:0006479)2.11917299
81Furrowed tongue (HP:0000221)2.08354262
82Asthma (HP:0002099)2.07876151
83Sparse eyelashes (HP:0000653)2.07435181
84Ankyloglossia (HP:0010296)2.05301620
85Achilles tendon contracture (HP:0001771)2.05216152
86Abnormality of the lacrimal duct (HP:0011481)2.04657310
87Protrusio acetabuli (HP:0003179)2.01766551
88Congenital ichthyosiform erythroderma (HP:0007431)11.1822166
89Abnormal hair laboratory examination (HP:0003328)1.98891127
90Round ear (HP:0100830)1.98156027
91Oligodontia (HP:0000677)1.95806724
92Everted lower lip vermilion (HP:0000232)1.95275128
93Abnormality of the Achilles tendon (HP:0005109)1.93141962
94Hyperhidrosis (HP:0000975)1.92567257
95Osteolytic defects of the phalanges of the hand (HP:0009771)1.89746067
96Osteolytic defects of the hand bones (HP:0009699)1.89746067
97Brittle hair (HP:0002299)1.89267238
98Skin ulcer (HP:0200042)1.88944291
99Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85311917
100Neonatal death (HP:0003811)1.85096901
101Muscle fiber splitting (HP:0003555)1.82450531
102Abnormality of the nasolacrimal system (HP:0000614)1.80892138
103Ventricular fibrillation (HP:0001663)1.80126037
104Ankle contracture (HP:0006466)1.78723610
105Breast hypoplasia (HP:0003187)1.76543167
106Distal lower limb amyotrophy (HP:0008944)1.76091870
107Ridged nail (HP:0001807)1.75865041
108Paralysis (HP:0003470)1.73957908
109Increased variability in muscle fiber diameter (HP:0003557)1.73856888
110Anhidrosis (HP:0000970)1.73346352
111Blepharitis (HP:0000498)1.73281658
112Abnormality of the salivary glands (HP:0010286)1.72063791
113Fine hair (HP:0002213)1.71879336
114Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69503704
115Steppage gait (HP:0003376)1.68864679
116Blue irides (HP:0000635)1.66361720
117Slender build (HP:0001533)1.66009975
118Recurrent corneal erosions (HP:0000495)1.65050860
119Mitral valve prolapse (HP:0001634)1.62843273
120Labial hypoplasia (HP:0000066)1.60996539
121Abnormality of secondary sexual hair (HP:0009888)1.60299473
122Abnormality of the axillary hair (HP:0100134)1.60299473
123Abnormality of skeletal muscle fiber size (HP:0012084)1.59074878
124Generalized hypopigmentation of hair (HP:0011358)1.57574931
125Dry hair (HP:0011359)1.57234712
126Urticaria (HP:0001025)1.56189952
127Hypoplastic labia majora (HP:0000059)1.55833260
128Abnormality of oral frenula (HP:0000190)1.54454048
129Villous atrophy (HP:0011473)1.53659231
130Abnormality of small intestinal villus morphology (HP:0011472)1.53659231
131Mildly elevated creatine phosphokinase (HP:0008180)1.53498016
132Pustule (HP:0200039)1.52434612
133Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.50960193
134Spinal rigidity (HP:0003306)1.50721081
135Soft skin (HP:0000977)1.50562303
136Cerebral aneurysm (HP:0004944)1.50472283
137Fair hair (HP:0002286)1.49666573
138Peritonitis (HP:0002586)1.49230476
139Sudden death (HP:0001699)1.48475165
140Stenosis of the external auditory canal (HP:0000402)1.48362377
141Anonychia (HP:0001798)1.47866039
142EMG: neuropathic changes (HP:0003445)1.47480789
143Absent hand (HP:0004050)1.46550093
144Dilatation of the ascending aorta (HP:0005111)1.45212001
145Hypoplastic female external genitalia (HP:0012815)1.44608783
146Coarse hair (HP:0002208)1.43598734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR16.48509909
2FGFR15.43675774
3MAPKAPK34.60735806
4MST1R4.19968812
5MAP3K23.21554560
6FER2.75932338
7RIPK12.70402375
8LATS12.59254300
9MST42.28497688
10TTN2.13750972
11MAP3K72.10654940
12ERN12.01099943
13TRPM71.87987618
14PIK3CG1.85082681
15MAP3K121.75941905
16OBSCN1.75891452
17MAP3K31.67480050
18SRPK11.60811260
19LATS21.58875218
20PAK31.57939531
21FRK1.51583761
22RPS6KB21.51265203
23MAPK71.51188110
24FGFR21.48373571
25SGK4941.46160025
26SGK2231.46160025
27MAP2K41.43619651
28NTRK21.43390286
29MARK21.41017336
30MAPKAPK51.36717008
31PBK1.30707851
32MAP3K111.28646263
33SGK21.25632873
34GRK51.24538844
35ITK1.24219141
36MAP3K91.22765190
37RPS6KB11.22460022
38ERBB31.20673435
39TYRO31.19079993
40NLK1.16940101
41MET1.16589418
42BMX1.13358720
43KIT1.13038242
44BMPR21.10400471
45PRKCH1.09338874
46FGR1.07699726
47TRIB31.06677412
48MAP3K11.04333051
49PTK61.01686192
50DYRK1B0.99563643
51SIK10.96647663
52EPHB20.96087395
53LRRK20.96045180
54STK240.95150577
55DDR20.92068193
56CDK60.89405843
57EEF2K0.86505432
58ERBB40.86185967
59BMPR1B0.85419607
60TAOK10.84375415
61STK110.84030106
62MAP2K60.82566292
63EPHA30.82020093
64MAP2K10.81311105
65STK380.79033826
66SGK30.78740901
67BCR0.77274309
68EPHA20.75091933
69TAOK30.74226221
70MAPKAPK20.73590185
71PDGFRA0.71995467
72MAP2K30.70858465
73TYK20.68782958
74CSNK1D0.67106672
75MAP3K140.66631033
76PRKD20.66575396
77CAMKK10.66271001
78MAPK130.65954728
79IRAK10.65058473
80PRPF4B0.61524990
81EPHA40.60837293
82PTK20.60639637
83PRKD10.60277860
84STK100.59670304
85PKN10.58583928
86FGFR30.58016590
87WNK10.57633352
88TGFBR20.56946133
89TBK10.54822712
90MAPK120.54589557
91GSK3A0.54360624
92PHKG20.53633708
93PHKG10.53633708
94GRK70.53459710
95AURKA0.52622854
96CDK30.51884441
97PINK10.51664019
98AKT30.51378390
99GRK60.51188916
100FGFR40.49552474
101ROCK10.48439410
102CASK0.46477711
103STK38L0.46245107
104ADRBK10.45600474
105STK30.45140962
106MTOR0.44211584
107CHUK0.40769630
108ACVR1B0.40457751
109CAMKK20.38855455
110CSNK1A1L0.38321395
111EPHB10.37488932
112IKBKE0.36668492
113ROCK20.35955575
114MAPK110.34093455
115ERBB20.32833296
116HIPK20.31901337
117ABL10.30921007
118PRKAA20.27556335
119MINK10.27049295
120IKBKB0.27013419
121SRC0.26841426
122BLK0.26770091
123MAPK90.26470661
124IGF1R0.25502609
125MAPK40.24611883
126RPS6KA20.24582092
127INSRR0.24348122
128PDGFRB0.23988443
129PRKCE0.23872203
130MAP3K60.23447856
131CDK50.23014709
132PKN20.23001041
133SGK10.21892413
134PIK3CA0.19864422
135GRK10.17868175
136ABL20.17329408
137ICK0.17017194
138MOS0.16840324
139STK390.15352577
140EIF2AK20.13921160
141RET0.13861970
142NEK60.13330907
143MAPK10.12838902
144CAMK40.12482822
145MAPK30.11354460
146TAF10.10166207

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.04896600
2ABC transporters_Homo sapiens_hsa020103.75433953
3Sphingolipid metabolism_Homo sapiens_hsa006003.35180839
4Phototransduction_Homo sapiens_hsa047443.17843508
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.86795477
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63717738
7Linoleic acid metabolism_Homo sapiens_hsa005912.59193064
8Tight junction_Homo sapiens_hsa045302.11845673
9Arachidonic acid metabolism_Homo sapiens_hsa005902.03293439
10Ovarian steroidogenesis_Homo sapiens_hsa049131.90847457
11Histidine metabolism_Homo sapiens_hsa003401.79310676
12Ether lipid metabolism_Homo sapiens_hsa005651.75182456
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71446518
14ECM-receptor interaction_Homo sapiens_hsa045121.51368396
15ErbB signaling pathway_Homo sapiens_hsa040121.50837891
16Long-term potentiation_Homo sapiens_hsa047201.46081473
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46012069
18Adherens junction_Homo sapiens_hsa045201.45306937
19Axon guidance_Homo sapiens_hsa043601.43927754
20Protein digestion and absorption_Homo sapiens_hsa049741.41655031
21Fat digestion and absorption_Homo sapiens_hsa049751.32884256
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31515199
23Staphylococcus aureus infection_Homo sapiens_hsa051501.31429525
24Renin secretion_Homo sapiens_hsa049241.22920424
25GnRH signaling pathway_Homo sapiens_hsa049121.16642044
26Choline metabolism in cancer_Homo sapiens_hsa052311.14824120
27VEGF signaling pathway_Homo sapiens_hsa043701.14697833
28Sphingolipid signaling pathway_Homo sapiens_hsa040711.11192654
29Amoebiasis_Homo sapiens_hsa051461.09804398
30Basal cell carcinoma_Homo sapiens_hsa052171.09289495
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.07280565
32Proteoglycans in cancer_Homo sapiens_hsa052051.03845702
33Melanogenesis_Homo sapiens_hsa049161.03026904
34Circadian rhythm_Homo sapiens_hsa047100.99614180
35Long-term depression_Homo sapiens_hsa047300.99092412
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98607389
37Retinol metabolism_Homo sapiens_hsa008300.97910015
38Hippo signaling pathway_Homo sapiens_hsa043900.95791287
39Gastric acid secretion_Homo sapiens_hsa049710.94958713
40Platelet activation_Homo sapiens_hsa046110.91758780
41Fatty acid biosynthesis_Homo sapiens_hsa000610.91232700
42mTOR signaling pathway_Homo sapiens_hsa041500.90966813
43Glutathione metabolism_Homo sapiens_hsa004800.89768335
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89096223
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88945650
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.87971212
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87200653
48Serotonergic synapse_Homo sapiens_hsa047260.86960449
49Insulin resistance_Homo sapiens_hsa049310.86210794
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85251562
51Pancreatic secretion_Homo sapiens_hsa049720.82233934
52Dorso-ventral axis formation_Homo sapiens_hsa043200.79607127
53Ras signaling pathway_Homo sapiens_hsa040140.76633412
54Vitamin digestion and absorption_Homo sapiens_hsa049770.76316504
55Malaria_Homo sapiens_hsa051440.75995953
56Oxytocin signaling pathway_Homo sapiens_hsa049210.75114238
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74111281
58Olfactory transduction_Homo sapiens_hsa047400.72278967
59Focal adhesion_Homo sapiens_hsa045100.71368512
60Endocytosis_Homo sapiens_hsa041440.70725623
61African trypanosomiasis_Homo sapiens_hsa051430.70369328
62Hepatitis C_Homo sapiens_hsa051600.69241908
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69056875
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68728436
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.67532877
66Rap1 signaling pathway_Homo sapiens_hsa040150.67448677
67Notch signaling pathway_Homo sapiens_hsa043300.66996975
68beta-Alanine metabolism_Homo sapiens_hsa004100.64027113
69Nitrogen metabolism_Homo sapiens_hsa009100.63316775
70Inositol phosphate metabolism_Homo sapiens_hsa005620.63030077
71MicroRNAs in cancer_Homo sapiens_hsa052060.62772472
72Fatty acid metabolism_Homo sapiens_hsa012120.62579825
73Glioma_Homo sapiens_hsa052140.61357711
74Estrogen signaling pathway_Homo sapiens_hsa049150.60180970
75Toxoplasmosis_Homo sapiens_hsa051450.59778809
76MAPK signaling pathway_Homo sapiens_hsa040100.59590729
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59525502
78Gap junction_Homo sapiens_hsa045400.58960255
79Pertussis_Homo sapiens_hsa051330.56905763
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56677705
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.55444440
82Amphetamine addiction_Homo sapiens_hsa050310.54482623
83Steroid biosynthesis_Homo sapiens_hsa001000.54245144
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53433048
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52741996
86PPAR signaling pathway_Homo sapiens_hsa033200.51821707
87p53 signaling pathway_Homo sapiens_hsa041150.51363817
88Glutamatergic synapse_Homo sapiens_hsa047240.50801040
89Wnt signaling pathway_Homo sapiens_hsa043100.50040643
90Complement and coagulation cascades_Homo sapiens_hsa046100.48960744
91Dopaminergic synapse_Homo sapiens_hsa047280.48827009
92Bladder cancer_Homo sapiens_hsa052190.48579911
93Acute myeloid leukemia_Homo sapiens_hsa052210.48568560
94Glucagon signaling pathway_Homo sapiens_hsa049220.48560989
95Tyrosine metabolism_Homo sapiens_hsa003500.48349149
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47959681
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47581796
98Fatty acid degradation_Homo sapiens_hsa000710.47373267
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46974819
100Circadian entrainment_Homo sapiens_hsa047130.46841807
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.46580922
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.45581682
103Dilated cardiomyopathy_Homo sapiens_hsa054140.44812009
104Small cell lung cancer_Homo sapiens_hsa052220.44705306
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43534641
106Tuberculosis_Homo sapiens_hsa051520.42427475
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41195099
108Hedgehog signaling pathway_Homo sapiens_hsa043400.41127068
109Renal cell carcinoma_Homo sapiens_hsa052110.40854128
110Calcium signaling pathway_Homo sapiens_hsa040200.40316229
111Salivary secretion_Homo sapiens_hsa049700.40128759
112Mineral absorption_Homo sapiens_hsa049780.39567153
113Thyroid cancer_Homo sapiens_hsa052160.39159984
114Non-small cell lung cancer_Homo sapiens_hsa052230.38272523
115Glycerolipid metabolism_Homo sapiens_hsa005610.37044480
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36601813
117Phenylalanine metabolism_Homo sapiens_hsa003600.36580210
118Arginine biosynthesis_Homo sapiens_hsa002200.36451115
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.35288271
120Lysosome_Homo sapiens_hsa041420.34625659
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34476245
122T cell receptor signaling pathway_Homo sapiens_hsa046600.34273556
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34261247
124Pathways in cancer_Homo sapiens_hsa052000.34153011
125cAMP signaling pathway_Homo sapiens_hsa040240.32785145
126Insulin signaling pathway_Homo sapiens_hsa049100.31402562
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30591065
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.29443838
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.26288471
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25351412
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21407553

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