ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	angiotensin maturation (GO:0002003)	8.30282835
2	lipoprotein transport (GO:0042953)	7.66261140
3	exogenous drug catabolic process (GO:0042738)	7.24964504
4	drug transmembrane transport (GO:0006855)	7.18748274
5	regulation of guanylate cyclase activity (GO:0031282)	7.07313333
6	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	6.44894593
7	drug catabolic process (GO:0042737)	6.42848888
8	epoxygenase P450 pathway (GO:0019373)	6.26932503
9	positive regulation of guanylate cyclase activity (GO:0031284)	6.06953739
10	drug transport (GO:0015893)	5.94797808
11	hormone catabolic process (GO:0042447)	5.84413033
12	neurotransmitter biosynthetic process (GO:0042136)	5.79485846
13	quaternary ammonium group transport (GO:0015697)	5.65692096
14	fat-soluble vitamin biosynthetic process (GO:0042362)	5.58597184
15	drug metabolic process (GO:0017144)	5.57090119
16	intestinal absorption (GO:0050892)	5.52556089
17	histamine transport (GO:0051608)	5.28959612
18	regulation of bile acid biosynthetic process (GO:0070857)	5.25164751
19	bile acid and bile salt transport (GO:0015721)	4.98375501
20	cellular glucuronidation (GO:0052695)	4.96185869
21	tooth mineralization (GO:0034505)	4.91457049
22	organic cation transport (GO:0015695)	4.87964261
23	uronic acid metabolic process (GO:0006063)	4.77584141
24	glucuronate metabolic process (GO:0019585)	4.77584141
25	regulation of triglyceride catabolic process (GO:0010896)	4.68439349
26	NADH metabolic process (GO:0006734)	4.58292366
27	neurotransmitter metabolic process (GO:0042133)	4.43645943
28	regulation of cGMP biosynthetic process (GO:0030826)	4.33841128
29	adhesion of symbiont to host cell (GO:0044650)	4.29403639
30	virion attachment to host cell (GO:0019062)	4.29403639
31	flavonoid metabolic process (GO:0009812)	4.17287862
32	regulation of systemic arterial blood pressure by hormone (GO:0001990)	4.09897360
33	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	4.09897360
34	endocrine process (GO:0050886)	4.09897360
35	fructose metabolic process (GO:0006000)	3.94433396
36	arginine metabolic process (GO:0006525)	3.93202640
37	meiotic chromosome segregation (GO:0045132)	3.83235466
38	histone H3-K36 demethylation (GO:0070544)	3.83162253
39	bile acid metabolic process (GO:0008206)	3.81617228
40	negative regulation of epidermal cell differentiation (GO:0045605)	3.76402242
41	very-low-density lipoprotein particle assembly (GO:0034379)	3.68361872
42	adhesion of symbiont to host (GO:0044406)	3.66732227
43	embryonic process involved in female pregnancy (GO:0060136)	3.65811259
44	bone trabecula formation (GO:0060346)	3.63211401
45	peptide catabolic process (GO:0043171)	3.60134741
46	vitamin A metabolic process (GO:0006776)	3.59653096
47	regulation of cGMP metabolic process (GO:0030823)	3.58933442
48	positive regulation of cGMP biosynthetic process (GO:0030828)	3.57317365
49	digestion (GO:0007586)	3.56988776
50	regulation of systemic arterial blood pressure (GO:0003073)	3.56820668
51	diacylglycerol metabolic process (GO:0046339)	3.56348054
52	phenol-containing compound catabolic process (GO:0019336)	3.54163953
53	urea cycle (GO:0000050)	3.52529123
54	fat-soluble vitamin metabolic process (GO:0006775)	3.50827940
55	regulation of cellular extravasation (GO:0002691)	3.50802864
56	urea metabolic process (GO:0019627)	3.48276585
57	lipoprotein metabolic process (GO:0042157)	3.46795948
58	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.41587152
59	glutamine family amino acid biosynthetic process (GO:0009084)	3.41052666
60	urate metabolic process (GO:0046415)	3.40909359
61	alkaloid metabolic process (GO:0009820)	3.40786194
62	peptide hormone processing (GO:0016486)	3.39896360
63	proline biosynthetic process (GO:0006561)	3.39862793
64	carnitine shuttle (GO:0006853)	3.36090381
65	omega-hydroxylase P450 pathway (GO:0097267)	3.34019637
66	renal system process involved in regulation of blood volume (GO:0001977)	3.33746323
67	amino-acid betaine transport (GO:0015838)	3.32976711
68	carnitine transport (GO:0015879)	3.32976711
69	high-density lipoprotein particle remodeling (GO:0034375)	3.32819861
70	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.29136363
71	vitamin transport (GO:0051180)	3.28416207
72	glycosylceramide metabolic process (GO:0006677)	3.27711437
73	plasma lipoprotein particle assembly (GO:0034377)	3.18088870
74	nitrogen cycle metabolic process (GO:0071941)	3.14681258
75	fatty acid transmembrane transport (GO:1902001)	3.14175823
76	C4-dicarboxylate transport (GO:0015740)	3.13333471
77	very long-chain fatty acid metabolic process (GO:0000038)	3.11763814
78	sphingomyelin metabolic process (GO:0006684)	3.09139235
79	positive regulation of cGMP metabolic process (GO:0030825)	3.06243791
80	phospholipid efflux (GO:0033700)	3.05062654
81	glycine transport (GO:0015816)	3.02947460
82	drinking behavior (GO:0042756)	3.01758486
83	sulfur compound transport (GO:0072348)	3.01651624
84	positive regulation of lipid catabolic process (GO:0050996)	3.01308441
85	proline metabolic process (GO:0006560)	3.00583538
86	azole transport (GO:0045117)	2.99850902
87	glycerol metabolic process (GO:0006071)	2.98927506
88	proline transport (GO:0015824)	2.98762701
89	carnitine transmembrane transport (GO:1902603)	2.96824266
90	homocysteine metabolic process (GO:0050667)	2.94170698
91	eosinophil chemotaxis (GO:0048245)	2.93284558
92	positive regulation of meiosis (GO:0045836)	2.93203254
93	cytidine metabolic process (GO:0046087)	2.92012090
94	cytidine catabolic process (GO:0006216)	2.92012090
95	cytidine deamination (GO:0009972)	2.92012090
96	arginine catabolic process (GO:0006527)	2.91727795
97	resolution of meiotic recombination intermediates (GO:0000712)	2.90771969
98	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.89635526
99	heme transport (GO:0015886)	2.88694198
100	macromolecular complex remodeling (GO:0034367)	2.86934289

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.58354689
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.50874937
3	CDX2_20551321_ChIP-Seq_CACO-2_Human	3.42767676
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.19755662
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.74535276
6	GATA4_25053715_ChIP-Seq_YYC3_Human	2.40642310
7	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.40111314
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.29554916
9	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	2.26038512
10	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.22648361
11	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.20158626
12	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.19918104
13	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.17167215
14	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.14359006
15	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.12410758
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.95947473
17	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.95069517
18	SOX2_20726797_ChIP-Seq_SW620_Human	1.89953112
19	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.87994199
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.82549988
21	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.80006801
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.78986530
23	GATA6_25053715_ChIP-Seq_YYC3_Human	1.77851630
24	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.77152819
25	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.72912785
26	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.65554657
27	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.62777569
28	EGR1_19032775_ChIP-ChIP_M12_Human	1.57306123
29	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.55690106
30	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.53834877
31	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.48264601
32	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.38978648
33	CDX2_22108803_ChIP-Seq_LS180_Human	1.35117705
34	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.34324970
35	E2F1_20622854_ChIP-Seq_HELA_Human	1.31894539
36	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.28399526
37	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.27280306
38	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.26665144
39	BCOR_27268052_Chip-Seq_Bcells_Human	1.26047824
40	PHF8_20622854_ChIP-Seq_HELA_Human	1.24127092
41	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.22069467
42	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.19265873
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18759629
44	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18295186
45	LXR_22292898_ChIP-Seq_THP-1_Human	1.16802404
46	RAC3_21632823_ChIP-Seq_H3396_Human	1.15123536
47	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14535623
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14163494
49	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.13195920
50	SA1_27219007_Chip-Seq_Bcells_Human	1.12201294
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.10905175
52	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.10609720
53	AR_20517297_ChIP-Seq_VCAP_Human	1.08000831
54	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.07521023
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07513807
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.05280402
57	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04780016
58	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.04405713
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04252414
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04252414
61	ZNF274_21170338_ChIP-Seq_K562_Hela	1.03716328
62	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.03599572
63	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.03364084
64	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.02377971
65	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.00648944
66	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.00171334
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00149012
68	KLF5_25053715_ChIP-Seq_YYC3_Human	0.99148052
69	NCOR_22424771_ChIP-Seq_293T_Human	0.97359307
70	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97156003
71	CTCF_27219007_Chip-Seq_Bcells_Human	0.95402609
72	P300_27268052_Chip-Seq_Bcells_Human	0.95246502
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95073404
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95014503
75	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.94426445
76	SOX2_21211035_ChIP-Seq_LN229_Human	0.94185346
77	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.91530441
78	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.91287766
79	GATA2_19941826_ChIP-Seq_K562_Human	0.91245932
80	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91071178
81	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.90889087
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.90038261
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.89260305
84	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.89201439
85	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.87887503
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.87859527
87	RXR_22108803_ChIP-Seq_LS180_Human	0.86902857
88	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.86772503
89	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.86309905
90	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.85606476
91	TP63_23658742_ChIP-Seq_EP156T_Human	0.85338572
92	TP63_22573176_ChIP-Seq_HFKS_Human	0.84848369
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.83763167
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.83490565
95	BCL6_27268052_Chip-Seq_Bcells_Human	0.83077289
96	ERA_21632823_ChIP-Seq_H3396_Human	0.81632341
97	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.81198437
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.81147697
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.80565229
100	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.79971009

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	8.73353464
2	MP0005085_abnormal_gallbladder_physiolo	5.33700259
3	MP0003806_abnormal_nucleotide_metabolis	4.77193991
4	MP0002139_abnormal_hepatobiliary_system	4.71866255
5	MP0005365_abnormal_bile_salt	4.22479662
6	MP0001666_abnormal_nutrient_absorption	4.03859788
7	MP0004147_increased_porphyrin_level	3.57067877
8	MP0003183_abnormal_peptide_metabolism	3.47152971
9	MP0004019_abnormal_vitamin_homeostasis	3.30747871
10	MP0009840_abnormal_foam_cell	2.92570327
11	MP0004264_abnormal_extraembryonic_tissu	2.89900597
12	MP0010329_abnormal_lipoprotein_level	2.63269421
13	MP0001664_abnormal_digestion	2.31439748
14	MP0009379_abnormal_foot_pigmentation	2.23810113
15	MP0004043_abnormal_pH_regulation	2.13101273
16	MP0003646_muscle_fatigue	2.11448926
17	MP0003252_abnormal_bile_duct	2.00344668
18	MP0009643_abnormal_urine_homeostasis	1.98635478
19	MP0005332_abnormal_amino_acid	1.96011078
20	MP0008875_abnormal_xenobiotic_pharmacok	1.89891047
21	MP0001873_stomach_inflammation	1.86147889
22	MP0010155_abnormal_intestine_physiology	1.79650951
23	MP0004858_abnormal_nervous_system	1.73655681
24	MP0008872_abnormal_physiological_respon	1.63675766
25	MP0002138_abnormal_hepatobiliary_system	1.58605802
26	MP0003868_abnormal_feces_composition	1.54210360
27	MP0001764_abnormal_homeostasis	1.51979956
28	MP0003866_abnormal_defecation	1.48220166
29	MP0003718_maternal_effect	1.44154530
30	MP0002876_abnormal_thyroid_physiology	1.43379998
31	MP0005670_abnormal_white_adipose	1.38569296
32	MP0003329_amyloid_beta_deposits	1.34343580
33	MP0001501_abnormal_sleep_pattern	1.34146060
34	MP0005409_darkened_coat_color	1.21904056
35	MP0002118_abnormal_lipid_homeostasis	1.20886369
36	MP0005448_abnormal_energy_balance	1.20654989
37	MP0000538_abnormal_urinary_bladder	1.20260459
38	MP0005636_abnormal_mineral_homeostasis	1.16393783
39	MP0005167_abnormal_blood-brain_barrier	1.14143250
40	MP0005166_decreased_susceptibility_to	1.12088827
41	MP0002136_abnormal_kidney_physiology	1.11423822
42	MP0001663_abnormal_digestive_system	1.08631544
43	MP0000490_abnormal_crypts_of	1.08329017
44	MP0001765_abnormal_ion_homeostasis	1.06197142
45	MP0001440_abnormal_grooming_behavior	1.05637055
46	MP0003879_abnormal_hair_cell	1.04419415
47	MP0000604_amyloidosis	0.99875141
48	MP0000609_abnormal_liver_physiology	0.97194668
49	MP0001919_abnormal_reproductive_system	0.96889479
50	MP0000477_abnormal_intestine_morphology	0.96788197
51	MP0005645_abnormal_hypothalamus_physiol	0.93256003
52	MP0000230_abnormal_systemic_arterial	0.88684715
53	MP0001756_abnormal_urination	0.87814869
54	MP0000678_abnormal_parathyroid_gland	0.86293143
55	MP0002837_dystrophic_cardiac_calcinosis	0.86070881
56	MP0002098_abnormal_vibrissa_morphology	0.85485382
57	MP0010234_abnormal_vibrissa_follicle	0.85172073
58	MP0005381_digestive/alimentary_phenotyp	0.84814642
59	MP0002160_abnormal_reproductive_system	0.83167170
60	MP0004484_altered_response_of	0.79870484
61	MP0005535_abnormal_body_temperature	0.79594852
62	MP0008004_abnormal_stomach_pH	0.79306208
63	MP0005584_abnormal_enzyme/coenzyme_acti	0.77613672
64	MP0005266_abnormal_metabolism	0.77101635
65	MP0003195_calcinosis	0.72393654
66	MP0001188_hyperpigmentation	0.72228617
67	MP0009697_abnormal_copulation	0.72203083
68	MP0009764_decreased_sensitivity_to	0.70944217
69	MP0006138_congestive_heart_failure	0.70625054
70	MP0008775_abnormal_heart_ventricle	0.70070884
71	MP0009115_abnormal_fat_cell	0.69858616
72	MP0005319_abnormal_enzyme/_coenzyme	0.67993795
73	MP0001845_abnormal_inflammatory_respons	0.67440819
74	MP0005387_immune_system_phenotype	0.66282057
75	MP0001790_abnormal_immune_system	0.66282057
76	MP0005376_homeostasis/metabolism_phenot	0.65802520
77	MP0009642_abnormal_blood_homeostasis	0.65251564
78	MP0009333_abnormal_splenocyte_physiolog	0.64195820
79	MP0002971_abnormal_brown_adipose	0.62284166
80	MP0003045_fibrosis	0.61925452
81	MP0000566_synostosis	0.58660364
82	MP0008469_abnormal_protein_level	0.57935657
83	MP0005389_reproductive_system_phenotype	0.57760370
84	MP0000427_abnormal_hair_cycle	0.56962858
85	MP0001835_abnormal_antigen_presentation	0.55520184
86	MP0000470_abnormal_stomach_morphology	0.55319312
87	MP0005410_abnormal_fertilization	0.55302447
88	MP0004130_abnormal_muscle_cell	0.54545502
89	MP0003953_abnormal_hormone_level	0.54406541
90	MP0003638_abnormal_response/metabolism_	0.54160252
91	MP0000249_abnormal_blood_vessel	0.53777662
92	MP0000462_abnormal_digestive_system	0.52869237
93	MP0010352_gastrointestinal_tract_polyps	0.47640054
94	MP0001485_abnormal_pinna_reflex	0.46634310
95	MP0002078_abnormal_glucose_homeostasis	0.46251464
96	MP0005334_abnormal_fat_pad	0.45082234
97	MP0006082_CNS_inflammation	0.43868996
98	MP0002148_abnormal_hypersensitivity_rea	0.43658410
99	MP0002796_impaired_skin_barrier	0.41375405
100	MP0002822_catalepsy	0.41261661

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	9.58511786
2	Abnormality of proline metabolism (HP:0010907)	7.19551196
3	Hydroxyprolinuria (HP:0003080)	7.19551196
4	Widely patent fontanelles and sutures (HP:0004492)	6.27430649
5	Conjugated hyperbilirubinemia (HP:0002908)	6.26978119
6	Malnutrition (HP:0004395)	5.54802465
7	Hypobetalipoproteinemia (HP:0003563)	5.51947395
8	Unilateral renal agenesis (HP:0000122)	5.46867575
9	Hyperglycinuria (HP:0003108)	4.66966168
10	Fat malabsorption (HP:0002630)	4.54700342
11	Abnormality of the vitamin B12 metabolism (HP:0004341)	4.40678462
12	Confusion (HP:0001289)	4.32500103
13	Hypoplasia of the fovea (HP:0007750)	4.27990970
14	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.27990970
15	Wide cranial sutures (HP:0010537)	4.23185604
16	Abnormality of vitamin B metabolism (HP:0004340)	4.09839852
17	Acanthocytosis (HP:0001927)	3.90629075
18	Posterior subcapsular cataract (HP:0007787)	3.89881497
19	Bilateral microphthalmos (HP:0007633)	3.86185976
20	Chronic diarrhea (HP:0002028)	3.73035235
21	Abnormality of glycine metabolism (HP:0010895)	3.68612299
22	Abnormality of serine family amino acid metabolism (HP:0010894)	3.68612299
23	Metabolic alkalosis (HP:0200114)	3.62220660
24	Decreased circulating renin level (HP:0003351)	3.58811144
25	Aplasia cutis congenita (HP:0001057)	3.57272740
26	Pigmentary retinal degeneration (HP:0001146)	3.56815569
27	Abnormality of vitamin metabolism (HP:0100508)	3.49701706
28	Nephrolithiasis (HP:0000787)	3.47050110
29	Ileus (HP:0002595)	3.38029765
30	Abnormality of urine glucose concentration (HP:0011016)	3.31626861
31	Glycosuria (HP:0003076)	3.31626861
32	Abnormality of the fovea (HP:0000493)	3.29835093
33	Alkalosis (HP:0001948)	3.24115255
34	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.21998774
35	Xanthomatosis (HP:0000991)	3.20197922
36	Steatorrhea (HP:0002570)	3.08214317
37	Nausea (HP:0002018)	3.04940512
38	Hypolipoproteinemia (HP:0010981)	2.89111273
39	Fused cervical vertebrae (HP:0002949)	2.81812586
40	Increased purine levels (HP:0004368)	2.80129327
41	Hyperuricemia (HP:0002149)	2.80129327
42	Aplasia/Hypoplasia of the macula (HP:0008059)	2.77360067
43	Intrahepatic cholestasis (HP:0001406)	2.76543187
44	Cerebral palsy (HP:0100021)	2.73146801
45	Renal tubular acidosis (HP:0001947)	2.71439347
46	Hyperlipoproteinemia (HP:0010980)	2.69565865
47	Hyperammonemia (HP:0001987)	2.67759891
48	Proximal tubulopathy (HP:0000114)	2.66588405
49	Systemic lupus erythematosus (HP:0002725)	2.63237000
50	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.59794776
51	Lower limb hyperreflexia (HP:0002395)	2.59128540
52	Abnormality of transition element cation homeostasis (HP:0011030)	2.57046406
53	Gout (HP:0001997)	2.56697784
54	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.55582234
55	Mixed hearing impairment (HP:0000410)	2.51503769
56	Abnormality of the right ventricle (HP:0001707)	2.50132992
57	Subcapsular cataract (HP:0000523)	2.48873167
58	Abnormality of renin-angiotensin system (HP:0000847)	2.47709762
59	Delayed epiphyseal ossification (HP:0002663)	2.45104410
60	Abnormality of purine metabolism (HP:0004352)	2.43584055
61	Abnormal glucose tolerance (HP:0001952)	2.42366255
62	Abdominal distention (HP:0003270)	2.39079727
63	Thin bony cortex (HP:0002753)	2.38962395
64	Megaloblastic anemia (HP:0001889)	2.37686213
65	Progressive inability to walk (HP:0002505)	2.30631083
66	Facial shape deformation (HP:0011334)	2.27418677
67	Potter facies (HP:0002009)	2.27418677
68	Enlarged epiphyses (HP:0010580)	2.27065382
69	Congenital sensorineural hearing impairment (HP:0008527)	2.25858197
70	Hyperactive renin-angiotensin system (HP:0000841)	2.25789590
71	Metabolic acidosis (HP:0001942)	2.24965292
72	Abnormality of nucleobase metabolism (HP:0010932)	2.23610851
73	Sensorimotor neuropathy (HP:0007141)	2.21397144
74	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.20973555
75	Hypophosphatemia (HP:0002148)	2.18002047
76	Epidermoid cyst (HP:0200040)	2.17146265
77	Abnormality of the parietal bone (HP:0002696)	2.14252037
78	Hyperbilirubinemia (HP:0002904)	2.08850163
79	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.99640912
80	Renal tubular dysfunction (HP:0000124)	1.98951705
81	Abnormality of iron homeostasis (HP:0011031)	1.95582251
82	Abnormal urine phosphate concentration (HP:0012599)	1.91113484
83	Pancreatitis (HP:0001733)	1.90658686
84	Focal segmental glomerulosclerosis (HP:0000097)	1.83709282
85	Hyperphosphaturia (HP:0003109)	1.81402535
86	Poikilocytosis (HP:0004447)	1.80986714
87	Abnormality of pyrimidine metabolism (HP:0004353)	1.80032950
88	Hypokalemia (HP:0002900)	1.79662173
89	Hypophosphatemic rickets (HP:0004912)	1.79390965
90	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.76222199
91	Hyperparathyroidism (HP:0000843)	1.67858489
92	Inability to walk (HP:0002540)	1.67705129
93	Right ventricular cardiomyopathy (HP:0011663)	1.66845900
94	Protuberant abdomen (HP:0001538)	1.65648312
95	Hemorrhage of the eye (HP:0011885)	1.65050776
96	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.64241304
97	Metaphyseal irregularity (HP:0003025)	1.60972167
98	Segmental peripheral demyelination/remyelination (HP:0003481)	1.60922899
99	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.59311797
100	Abnormality of small intestinal villus morphology (HP:0011472)	1.59000726

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RIPK4	7.20984331
2	ACVR1B	6.40546260
3	BMPR2	4.59465666
4	PINK1	3.70909644
5	TLK1	3.59296402
6	SIK3	2.60446953
7	MST1R	2.22197480
8	ERN1	2.06275122
9	MAP3K11	1.99378329
10	MAP3K7	1.98254699
11	PRKG2	1.96445841
12	SIK2	1.96137803
13	NEK2	1.95329925
14	ERBB2	1.89927646
15	SIK1	1.82730061
16	ICK	1.74397842
17	RIPK1	1.66773880
18	OXSR1	1.50746307
19	STK11	1.50546300
20	MAP3K12	1.42686024
21	EEF2K	1.33201393
22	DAPK2	1.32253354
23	MAP3K10	1.31060487
24	EPHA2	1.28205575
25	MELK	1.25820410
26	PIK3CA	1.25088367
27	STK39	1.23127824
28	PRKAA2	1.21517261
29	MET	1.18325351
30	MAPKAPK3	1.13234754
31	TIE1	1.11609058
32	BTK	1.08010068
33	ADRBK2	1.00954804
34	MST4	0.97175264
35	MAP3K1	0.95553361
36	MARK3	0.93028073
37	TNIK	0.90374540
38	CDC42BPA	0.84538369
39	MATK	0.82822463
40	STK3	0.78730833
41	GRK1	0.78653570
42	STK38	0.78508411
43	PTK6	0.77436642
44	MAPKAPK5	0.75029882
45	PRKCZ	0.73477172
46	MYLK	0.70026268
47	PRKACG	0.68221598
48	MAP3K2	0.68150293
49	IRAK1	0.65142168
50	PDPK1	0.64822491
51	MAP3K3	0.63838723
52	BCR	0.63735765
53	MAP4K1	0.59133510
54	FRK	0.58919790
55	PDK2	0.58729965
56	PRKAA1	0.56609013
57	PRKCA	0.56367625
58	SYK	0.55349990
59	GRK6	0.53669521
60	PRKCI	0.53100885
61	TAOK3	0.52919440
62	TYK2	0.50316134
63	EPHA4	0.48797169
64	EPHB2	0.47881147
65	STK38L	0.46099691
66	CAMK4	0.43251693
67	TEC	0.42359262
68	RPS6KA6	0.40785457
69	AKT3	0.39675811
70	TESK2	0.39521978
71	PIM1	0.38930775
72	MAP2K2	0.38331885
73	NLK	0.37267567
74	MAPK7	0.35711159
75	MAPK11	0.34610217
76	EPHA3	0.33890606
77	DAPK1	0.33588879
78	WNK4	0.32936297
79	ILK	0.32500674
80	PDK1	0.32201601
81	PIK3CG	0.31950175
82	FGFR4	0.31435444
83	IGF1R	0.30120481
84	ITK	0.30093362
85	FLT3	0.29862348
86	MAPK4	0.28559527
87	MAP2K1	0.28284799
88	EPHB1	0.27390152
89	DDR2	0.26037959
90	TXK	0.25843415
91	CAMK2D	0.24389624
92	ADRBK1	0.23351316
93	MUSK	0.22199513
94	CAMK2A	0.22089959
95	MAP2K6	0.21535676
96	JAK3	0.21501038
97	RET	0.21059491
98	PRKCD	0.20884749
99	CDK19	0.20367719
100	IRAK4	0.20316795

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin digestion and absorption_Homo sapiens_hsa04977	4.35773667
2	Fat digestion and absorption_Homo sapiens_hsa04975	3.99395865
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.89375455
4	Caffeine metabolism_Homo sapiens_hsa00232	3.40764896
5	Renin-angiotensin system_Homo sapiens_hsa04614	3.36878666
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.88054610
7	Histidine metabolism_Homo sapiens_hsa00340	2.68743627
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.52425642
9	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.48755275
10	Arginine biosynthesis_Homo sapiens_hsa00220	2.48088161
11	Chemical carcinogenesis_Homo sapiens_hsa05204	2.42638469
12	Mineral absorption_Homo sapiens_hsa04978	2.41376007
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.39556951
14	Retinol metabolism_Homo sapiens_hsa00830	2.35134671
15	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.30949695
16	Protein digestion and absorption_Homo sapiens_hsa04974	2.19396869
17	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.19058660
18	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.13756518
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.09085846
20	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.04523693
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.93965768
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.86133448
23	Bile secretion_Homo sapiens_hsa04976	1.81946312
24	Arginine and proline metabolism_Homo sapiens_hsa00330	1.72031416
25	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.68892199
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.48710684
27	Galactose metabolism_Homo sapiens_hsa00052	1.48680211
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.47007749
29	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.37646637
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.32048789
31	Sulfur metabolism_Homo sapiens_hsa00920	1.28344654
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25067953
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.16798691
34	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.16617812
35	Glycerolipid metabolism_Homo sapiens_hsa00561	1.12326462
36	Fatty acid degradation_Homo sapiens_hsa00071	1.05574724
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.04163156
38	Olfactory transduction_Homo sapiens_hsa04740	1.01846735
39	Phenylalanine metabolism_Homo sapiens_hsa00360	1.01174698
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90421738
41	ABC transporters_Homo sapiens_hsa02010	0.80055458
42	Tyrosine metabolism_Homo sapiens_hsa00350	0.76711060
43	Fatty acid elongation_Homo sapiens_hsa00062	0.70432372
44	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.68380281
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.64016116
46	Allograft rejection_Homo sapiens_hsa05330	0.63765297
47	Peroxisome_Homo sapiens_hsa04146	0.63267532
48	Asthma_Homo sapiens_hsa05310	0.61861190
49	African trypanosomiasis_Homo sapiens_hsa05143	0.58355550
50	Sphingolipid metabolism_Homo sapiens_hsa00600	0.57362547
51	Glutathione metabolism_Homo sapiens_hsa00480	0.56892337
52	Pentose phosphate pathway_Homo sapiens_hsa00030	0.55455223
53	Pancreatic secretion_Homo sapiens_hsa04972	0.54901345
54	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.54851493
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54737239
56	Insulin resistance_Homo sapiens_hsa04931	0.54243267
57	Butanoate metabolism_Homo sapiens_hsa00650	0.53891312
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53150198
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.51915654
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51199258
61	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46161758
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45678363
63	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.44157519
64	Graft-versus-host disease_Homo sapiens_hsa05332	0.42901335
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42711451
66	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.41835631
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41166601
68	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.39857532
69	Choline metabolism in cancer_Homo sapiens_hsa05231	0.38163274
70	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.33311510
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.33201895
72	Sulfur relay system_Homo sapiens_hsa04122	0.31363917
73	Renin secretion_Homo sapiens_hsa04924	0.30211094
74	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.29892714
75	Serotonergic synapse_Homo sapiens_hsa04726	0.29886376
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.29816675
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.29360732
78	Long-term depression_Homo sapiens_hsa04730	0.29221293
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.28073457
80	Insulin secretion_Homo sapiens_hsa04911	0.27673409
81	Salivary secretion_Homo sapiens_hsa04970	0.26362220
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.25866990
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.24653739
84	Metabolic pathways_Homo sapiens_hsa01100	0.24129756
85	Propanoate metabolism_Homo sapiens_hsa00640	0.20046866
86	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.18660592
87	Gastric acid secretion_Homo sapiens_hsa04971	0.17979586
88	Cocaine addiction_Homo sapiens_hsa05030	0.16344634
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.15312914
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.14550288
91	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.11012291
92	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.10986421
93	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.10039153
94	Complement and coagulation cascades_Homo sapiens_hsa04610	0.09486002
95	AMPK signaling pathway_Homo sapiens_hsa04152	0.09169362
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.09095435
97	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.09074645
98	Carbon metabolism_Homo sapiens_hsa01200	0.07063587
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.06870837
100	Amphetamine addiction_Homo sapiens_hsa05031	0.04928677

FLJ22763

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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