ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.21036974
2	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.79317486
3	DNA deamination (GO:0045006)	4.68593870
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.53489986
5	response to pheromone (GO:0019236)	4.33938897
6	piRNA metabolic process (GO:0034587)	4.32109560
7	negative regulation of cAMP-mediated signaling (GO:0043951)	4.31599071
8	opioid receptor signaling pathway (GO:0038003)	4.23625301
9	behavioral response to ethanol (GO:0048149)	4.16463037
10	L-fucose catabolic process (GO:0042355)	4.02151639
11	fucose catabolic process (GO:0019317)	4.02151639
12	L-fucose metabolic process (GO:0042354)	4.02151639
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.77280176
14	kynurenine metabolic process (GO:0070189)	3.76641341
15	indole-containing compound catabolic process (GO:0042436)	3.69887577
16	indolalkylamine catabolic process (GO:0046218)	3.69887577
17	tryptophan catabolic process (GO:0006569)	3.69887577
18	indolalkylamine metabolic process (GO:0006586)	3.68752976
19	detection of light stimulus involved in sensory perception (GO:0050962)	3.37895681
20	detection of light stimulus involved in visual perception (GO:0050908)	3.37895681
21	negative regulation of telomere maintenance (GO:0032205)	3.36181925
22	cellular ketone body metabolic process (GO:0046950)	3.32328456
23	preassembly of GPI anchor in ER membrane (GO:0016254)	3.31142543
24	adult feeding behavior (GO:0008343)	3.23525974
25	epithelial cilium movement (GO:0003351)	3.21926791
26	positive regulation of fatty acid transport (GO:2000193)	3.21302262
27	cellular biogenic amine catabolic process (GO:0042402)	3.18927397
28	amine catabolic process (GO:0009310)	3.18927397
29	platelet dense granule organization (GO:0060155)	3.17256130
30	axoneme assembly (GO:0035082)	3.13999493
31	respiratory chain complex IV assembly (GO:0008535)	3.08673394
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.03678414
33	glycerophospholipid catabolic process (GO:0046475)	3.02401440
34	tryptophan metabolic process (GO:0006568)	3.00867641
35	adaptation of signaling pathway (GO:0023058)	3.00222469
36	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97273710
37	ketone body metabolic process (GO:1902224)	2.95147079
38	positive regulation of cAMP-mediated signaling (GO:0043950)	2.90681196
39	pyrimidine nucleobase catabolic process (GO:0006208)	2.88300026
40	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.87623360
41	neuronal action potential (GO:0019228)	2.85387129
42	regulation of cilium movement (GO:0003352)	2.85200630
43	protein complex biogenesis (GO:0070271)	2.85100411
44	photoreceptor cell maintenance (GO:0045494)	2.84817614
45	regulation of action potential (GO:0098900)	2.84045873
46	positive regulation of icosanoid secretion (GO:0032305)	2.82141380
47	protein polyglutamylation (GO:0018095)	2.81642766
48	reflex (GO:0060004)	2.79945524
49	protein K11-linked deubiquitination (GO:0035871)	2.76341938
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.75771837
51	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.75771837
52	NADH dehydrogenase complex assembly (GO:0010257)	2.75771837
53	cilium morphogenesis (GO:0060271)	2.74973423
54	rhodopsin mediated signaling pathway (GO:0016056)	2.74307414
55	protein neddylation (GO:0045116)	2.73708980
56	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.73625201
57	regulation of acrosome reaction (GO:0060046)	2.73421925
58	DNA methylation involved in gamete generation (GO:0043046)	2.73328281
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.73102401
60	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.73102401
61	kidney morphogenesis (GO:0060993)	2.72698629
62	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.70770697
63	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.69913907
64	cytochrome complex assembly (GO:0017004)	2.69120063
65	regulation of memory T cell differentiation (GO:0043380)	2.68927140
66	transmission of nerve impulse (GO:0019226)	2.66770932
67	chaperone-mediated protein transport (GO:0072321)	2.66422847
68	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64820772
69	nucleobase catabolic process (GO:0046113)	2.64741500
70	mitochondrial respiratory chain complex assembly (GO:0033108)	2.63688172
71	GPI anchor metabolic process (GO:0006505)	2.63350591
72	positive regulation of prostaglandin secretion (GO:0032308)	2.63138576
73	neural tube formation (GO:0001841)	2.62681575
74	sperm motility (GO:0030317)	2.59597837
75	thyroid hormone metabolic process (GO:0042403)	2.59353786
76	multicellular organism reproduction (GO:0032504)	2.58640727
77	cilium movement (GO:0003341)	2.58571104
78	synaptic transmission, cholinergic (GO:0007271)	2.57465109
79	regulation of hexokinase activity (GO:1903299)	2.57430231
80	regulation of glucokinase activity (GO:0033131)	2.57430231
81	cornea development in camera-type eye (GO:0061303)	2.56682759
82	mannosylation (GO:0097502)	2.56217902
83	retinal cone cell development (GO:0046549)	2.56016825
84	protein-cofactor linkage (GO:0018065)	2.54653313
85	indole-containing compound metabolic process (GO:0042430)	2.54184439
86	reciprocal DNA recombination (GO:0035825)	2.53737340
87	reciprocal meiotic recombination (GO:0007131)	2.53737340
88	regulation of neurotransmitter uptake (GO:0051580)	2.53445872
89	inositol phosphate catabolic process (GO:0071545)	2.52733271
90	negative regulation of mast cell activation (GO:0033004)	2.48501679
91	nonmotile primary cilium assembly (GO:0035058)	2.45876413
92	male meiosis I (GO:0007141)	2.45029523
93	cellular response to ATP (GO:0071318)	2.44068586
94	dopamine transport (GO:0015872)	2.43984542
95	serotonin receptor signaling pathway (GO:0007210)	2.43942190
96	male meiosis (GO:0007140)	2.43324103
97	inositol phosphate dephosphorylation (GO:0046855)	2.43180670
98	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.43180670
99	sulfation (GO:0051923)	2.43144063
100	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.41373694

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.91797804
2	VDR_22108803_ChIP-Seq_LS180_Human	3.39413411
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.93719597
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.84615875
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.74965378
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.62918844
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.54979950
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.32190967
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24837804
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.22323851
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.17905695
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10098229
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.04962219
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99428166
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99275077
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95582736
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91388736
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.90151607
19	FUS_26573619_Chip-Seq_HEK293_Human	1.86451194
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83133857
21	P300_19829295_ChIP-Seq_ESCs_Human	1.82590328
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79144162
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.77675194
24	EWS_26573619_Chip-Seq_HEK293_Human	1.73163961
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.66273450
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.57852882
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.54764711
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54764711
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52861303
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52681215
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50905819
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50905819
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49779902
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48998925
35	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.47756459
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.45136455
37	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43401687
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43401687
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42135115
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42051052
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41927966
42	STAT3_23295773_ChIP-Seq_U87_Human	1.40575611
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39073954
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38790273
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.38455223
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38336312
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37157044
48	TCF4_23295773_ChIP-Seq_U87_Human	1.36653659
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34070383
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34070383
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33518401
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32952303
53	AR_25329375_ChIP-Seq_VCAP_Human	1.32110945
54	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.31409933
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30064818
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29103009
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28593107
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28172126
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28153707
60	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.28068412
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24514393
62	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.22510057
63	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.22157439
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.21376372
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20940281
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.20749846
67	NCOR_22424771_ChIP-Seq_293T_Human	1.20616213
68	AR_20517297_ChIP-Seq_VCAP_Human	1.18947502
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18865814
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18429472
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17860767
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13989925
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12650450
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12253159
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11207599
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10639121
77	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10332373
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10199390
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09946598
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08982808
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08595361
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08411470
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07947853
84	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.07807651
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07622650
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07068006
87	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.05807567
88	CDX2_22108803_ChIP-Seq_LS180_Human	1.03986163
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03266408
90	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02073171
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01890053
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01077997
93	MYC_19829295_ChIP-Seq_ESCs_Human	1.00890239
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99945370
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99895682
96	ERA_21632823_ChIP-Seq_H3396_Human	0.99026278
97	VDR_23849224_ChIP-Seq_CD4+_Human	0.98934029
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97507367
99	AR_21572438_ChIP-Seq_LNCaP_Human	0.96956826
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95696186

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.13057547
2	MP0002876_abnormal_thyroid_physiology	2.85821959
3	MP0001968_abnormal_touch/_nociception	2.72770669
4	MP0005551_abnormal_eye_electrophysiolog	2.62554605
5	MP0002837_dystrophic_cardiac_calcinosis	2.61943179
6	MP0003787_abnormal_imprinting	2.60959197
7	MP0006072_abnormal_retinal_apoptosis	2.59957324
8	MP0005646_abnormal_pituitary_gland	2.50476511
9	MP0002638_abnormal_pupillary_reflex	2.49988514
10	MP0002102_abnormal_ear_morphology	2.33922850
11	MP0008875_abnormal_xenobiotic_pharmacok	2.12963145
12	MP0003880_abnormal_central_pattern	2.03044673
13	MP0003646_muscle_fatigue	1.97530457
14	MP0006276_abnormal_autonomic_nervous	1.95362525
15	MP0008872_abnormal_physiological_respon	1.93954067
16	MP0009745_abnormal_behavioral_response	1.87474735
17	MP0004142_abnormal_muscle_tone	1.87402860
18	MP0006292_abnormal_olfactory_placode	1.87332816
19	MP0003195_calcinosis	1.83169461
20	MP0005253_abnormal_eye_physiology	1.77429091
21	MP0009780_abnormal_chondrocyte_physiolo	1.76519630
22	MP0005645_abnormal_hypothalamus_physiol	1.72877735
23	MP0000372_irregular_coat_pigmentation	1.71683977
24	MP0002163_abnormal_gland_morphology	1.70630102
25	MP0004043_abnormal_pH_regulation	1.68617444
26	MP0009046_muscle_twitch	1.67618059
27	MP0004147_increased_porphyrin_level	1.65191951
28	MP0002272_abnormal_nervous_system	1.63748017
29	MP0003011_delayed_dark_adaptation	1.63117983
30	MP0001986_abnormal_taste_sensitivity	1.60910197
31	MP0002736_abnormal_nociception_after	1.59510325
32	MP0001501_abnormal_sleep_pattern	1.57041337
33	MP0004133_heterotaxia	1.55520551
34	MP0001485_abnormal_pinna_reflex	1.53924772
35	MP0001984_abnormal_olfaction	1.50106930
36	MP0001529_abnormal_vocalization	1.49329409
37	MP0002733_abnormal_thermal_nociception	1.48236995
38	MP0004885_abnormal_endolymph	1.46698277
39	MP0005379_endocrine/exocrine_gland_phen	1.42296384
40	MP0001486_abnormal_startle_reflex	1.42233038
41	MP0001970_abnormal_pain_threshold	1.35114946
42	MP0003122_maternal_imprinting	1.29810429
43	MP0000427_abnormal_hair_cycle	1.27603226
44	MP0005084_abnormal_gallbladder_morpholo	1.27478348
45	MP0002557_abnormal_social/conspecific_i	1.27140732
46	MP0002735_abnormal_chemical_nociception	1.25930807
47	MP0000631_abnormal_neuroendocrine_gland	1.25621201
48	MP0008775_abnormal_heart_ventricle	1.24400847
49	MP0002572_abnormal_emotion/affect_behav	1.24016028
50	MP0002064_seizures	1.21571657
51	MP0005389_reproductive_system_phenotype	1.19699120
52	MP0001905_abnormal_dopamine_level	1.18488303
53	MP0003121_genomic_imprinting	1.14444189
54	MP0003136_yellow_coat_color	1.10870350
55	MP0000569_abnormal_digit_pigmentation	1.10212194
56	MP0005195_abnormal_posterior_eye	1.09208446
57	MP0000230_abnormal_systemic_arterial	1.09191585
58	MP0004742_abnormal_vestibular_system	1.08437698
59	MP0001919_abnormal_reproductive_system	1.08248270
60	MP0002938_white_spotting	1.06677008
61	MP0009764_decreased_sensitivity_to	1.05692184
62	MP0002234_abnormal_pharynx_morphology	1.04027058
63	MP0003283_abnormal_digestive_organ	1.02003595
64	MP0005410_abnormal_fertilization	1.01878848
65	MP0002653_abnormal_ependyma_morphology	1.00657518
66	MP0002693_abnormal_pancreas_physiology	0.98360288
67	MP0002160_abnormal_reproductive_system	0.98268063
68	MP0003183_abnormal_peptide_metabolism	0.97589413
69	MP0005360_urolithiasis	0.96342050
70	MP0005386_behavior/neurological_phenoty	0.96190141
71	MP0004924_abnormal_behavior	0.96190141
72	MP0002063_abnormal_learning/memory/cond	0.95710508
73	MP0001502_abnormal_circadian_rhythm	0.95696421
74	MP0002095_abnormal_skin_pigmentation	0.95569142
75	MP0002067_abnormal_sensory_capabilities	0.95073739
76	MP0005083_abnormal_biliary_tract	0.94721843
77	MP0005174_abnormal_tail_pigmentation	0.94252618
78	MP0006035_abnormal_mitochondrial_morpho	0.93837542
79	MP0005377_hearing/vestibular/ear_phenot	0.90729951
80	MP0003878_abnormal_ear_physiology	0.90729951
81	MP0000778_abnormal_nervous_system	0.90251974
82	MP0003635_abnormal_synaptic_transmissio	0.89460723
83	MP0000383_abnormal_hair_follicle	0.88781680
84	MP0002752_abnormal_somatic_nervous	0.86387099
85	MP0008789_abnormal_olfactory_epithelium	0.85629919
86	MP0005670_abnormal_white_adipose	0.85040799
87	MP0002138_abnormal_hepatobiliary_system	0.84311755
88	MP0002928_abnormal_bile_duct	0.83811714
89	MP0001944_abnormal_pancreas_morphology	0.83534409
90	MP0003698_abnormal_male_reproductive	0.83271091
91	MP0005167_abnormal_blood-brain_barrier	0.82832058
92	MP0005332_abnormal_amino_acid	0.82684162
93	MP0010386_abnormal_urinary_bladder	0.81240471
94	MP0002229_neurodegeneration	0.79954413
95	MP0001963_abnormal_hearing_physiology	0.79635333
96	MP0004215_abnormal_myocardial_fiber	0.78262409
97	MP0005085_abnormal_gallbladder_physiolo	0.76779758
98	MP0002734_abnormal_mechanical_nocicepti	0.76031495
99	MP0002184_abnormal_innervation	0.75363577
100	MP0000015_abnormal_ear_pigmentation	0.75247378

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.02364023
2	Congenital stationary night blindness (HP:0007642)	3.97022675
3	Molar tooth sign on MRI (HP:0002419)	3.88482519
4	Abnormality of midbrain morphology (HP:0002418)	3.88482519
5	Thyroid-stimulating hormone excess (HP:0002925)	3.73824330
6	Pancreatic fibrosis (HP:0100732)	3.71905910
7	True hermaphroditism (HP:0010459)	3.55008578
8	Abnormality of the renal cortex (HP:0011035)	3.54966893
9	Nephronophthisis (HP:0000090)	3.50763461
10	Tubular atrophy (HP:0000092)	3.26230165
11	Abnormality of the renal medulla (HP:0100957)	3.17743773
12	Attenuation of retinal blood vessels (HP:0007843)	3.10855795
13	Type II lissencephaly (HP:0007260)	3.09641999
14	Abolished electroretinogram (ERG) (HP:0000550)	2.99864878
15	Abnormal rod and cone electroretinograms (HP:0008323)	2.90122657
16	Polydipsia (HP:0001959)	2.88852583
17	Abnormal drinking behavior (HP:0030082)	2.88852583
18	Pendular nystagmus (HP:0012043)	2.86654818
19	Agitation (HP:0000713)	2.86098524
20	Intestinal atresia (HP:0011100)	2.82025798
21	Medial flaring of the eyebrow (HP:0010747)	2.69509120
22	Renal cortical cysts (HP:0000803)	2.67117436
23	Chronic hepatic failure (HP:0100626)	2.63164590
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.55695291
25	Large for gestational age (HP:0001520)	2.44348918
26	Increased CSF lactate (HP:0002490)	2.44173141
27	Cerebellar dysplasia (HP:0007033)	2.42755014
28	Polyuria (HP:0000103)	2.38554342
29	Lissencephaly (HP:0001339)	2.38391912
30	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.36345540
31	Decreased circulating renin level (HP:0003351)	2.35846414
32	Hepatocellular necrosis (HP:0001404)	2.35089830
33	Cystic liver disease (HP:0006706)	2.35042119
34	Mitochondrial inheritance (HP:0001427)	2.33865687
35	Methylmalonic acidemia (HP:0002912)	2.33037343
36	Hyperventilation (HP:0002883)	2.32985587
37	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.30127794
38	Gaze-evoked nystagmus (HP:0000640)	2.23997546
39	Optic nerve hypoplasia (HP:0000609)	2.23990275
40	Increased corneal curvature (HP:0100692)	2.23431533
41	Keratoconus (HP:0000563)	2.23431533
42	Hepatic necrosis (HP:0002605)	2.22683072
43	Bony spicule pigmentary retinopathy (HP:0007737)	2.22253870
44	Methylmalonic aciduria (HP:0012120)	2.21889666
45	Volvulus (HP:0002580)	2.20382853
46	Lipid accumulation in hepatocytes (HP:0006561)	2.19613114
47	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.18020023
48	Asplenia (HP:0001746)	2.17660051
49	Hyperglycinemia (HP:0002154)	2.14977704
50	Progressive inability to walk (HP:0002505)	2.10127739
51	Sclerocornea (HP:0000647)	2.09836931
52	Decreased central vision (HP:0007663)	2.09467257
53	Gait imbalance (HP:0002141)	2.08674087
54	Focal motor seizures (HP:0011153)	2.08308892
55	Ketoacidosis (HP:0001993)	2.08073688
56	Inability to walk (HP:0002540)	2.06784107
57	Abnormality of the pons (HP:0007361)	2.06711936
58	Hypoplasia of the pons (HP:0012110)	2.05615829
59	Congenital primary aphakia (HP:0007707)	2.01261704
60	Increased hepatocellular lipid droplets (HP:0006565)	1.98184242
61	3-Methylglutaconic aciduria (HP:0003535)	1.97553065
62	Stomatitis (HP:0010280)	1.96715761
63	Mesangial abnormality (HP:0001966)	1.93938243
64	Congenital hepatic fibrosis (HP:0002612)	1.92784543
65	Acute necrotizing encephalopathy (HP:0006965)	1.92572054
66	Male pseudohermaphroditism (HP:0000037)	1.92320546
67	Ketosis (HP:0001946)	1.92057078
68	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91968596
69	Abnormality of the labia minora (HP:0012880)	1.91539364
70	Pachygyria (HP:0001302)	1.91434464
71	Oligodactyly (hands) (HP:0001180)	1.90071211
72	Constricted visual fields (HP:0001133)	1.89458632
73	Abnormal urine output (HP:0012590)	1.87034013
74	Severe muscular hypotonia (HP:0006829)	1.86260521
75	Optic disc pallor (HP:0000543)	1.85951432
76	Progressive macrocephaly (HP:0004481)	1.85529665
77	Congenital sensorineural hearing impairment (HP:0008527)	1.85101153
78	Anencephaly (HP:0002323)	1.84676867
79	Dyskinesia (HP:0100660)	1.84084854
80	Nephrogenic diabetes insipidus (HP:0009806)	1.81928872
81	Hypomagnesemia (HP:0002917)	1.81624455
82	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.80172853
83	Abnormality of alanine metabolism (HP:0010916)	1.80172853
84	Hyperalaninemia (HP:0003348)	1.80172853
85	Furrowed tongue (HP:0000221)	1.80130300
86	Increased serum lactate (HP:0002151)	1.80105308
87	Broad-based gait (HP:0002136)	1.78760915
88	Tubulointerstitial abnormality (HP:0001969)	1.78117901
89	Abnormality of glycine metabolism (HP:0010895)	1.77317690
90	Abnormality of serine family amino acid metabolism (HP:0010894)	1.77317690
91	Hypothermia (HP:0002045)	1.77189039
92	Hypoproteinemia (HP:0003075)	1.76057736
93	Pancreatic islet-cell hyperplasia (HP:0004510)	1.75864633
94	Postaxial foot polydactyly (HP:0001830)	1.75023812
95	Amelogenesis imperfecta (HP:0000705)	1.74687140
96	Retinitis pigmentosa (HP:0000510)	1.74616881
97	Hypoplasia of the fovea (HP:0007750)	1.74403887
98	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.74403887
99	Abnormality of macular pigmentation (HP:0008002)	1.73160632
100	Disproportionate short-trunk short stature (HP:0003521)	1.73120277

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.15269259
2	ADRBK2	4.46210713
3	MAP4K2	3.03681050
4	BMPR1B	2.80329604
5	TAOK3	2.73450077
6	ZAK	2.63833581
7	PINK1	2.63733379
8	WNK3	2.52253776
9	NUAK1	2.47518949
10	WNK4	2.39047642
11	TLK1	2.38880996
12	GRK1	2.22117309
13	TXK	1.92235374
14	STK39	1.66884569
15	INSRR	1.61239519
16	OXSR1	1.60332003
17	MAP2K6	1.54284126
18	ACVR1B	1.49709343
19	CASK	1.37219790
20	MAPK13	1.36895253
21	ADRBK1	1.33490446
22	MAP3K4	1.30206332
23	MST4	1.30020946
24	PRKCG	1.26701687
25	DAPK2	1.25326774
26	TRIM28	1.22914734
27	PRKCE	1.19772875
28	PLK2	1.16784072
29	PAK3	1.12569091
30	TGFBR1	1.12195311
31	FGFR2	1.11613225
32	PHKG1	1.03487443
33	PHKG2	1.03487443
34	DYRK2	1.02296978
35	BCKDK	0.97458032
36	CSNK1G2	0.95474364
37	MAP2K7	0.92174254
38	CSNK1G3	0.91693372
39	MKNK2	0.90968642
40	CAMKK2	0.89720735
41	CSNK1G1	0.89383362
42	IRAK1	0.88859681
43	SIK2	0.86653219
44	VRK1	0.83933610
45	STK38L	0.82493503
46	EIF2AK3	0.82456926
47	CSNK1A1L	0.77910771
48	CDK8	0.77286965
49	PRKCI	0.75971418
50	PIK3CA	0.74442970
51	TEC	0.73818509
52	TNK2	0.71498405
53	MARK1	0.70305961
54	EPHA3	0.63128435
55	STK3	0.60238486
56	PTK2B	0.59703135
57	ERBB3	0.59245737
58	TNIK	0.58206618
59	KIT	0.57797666
60	TIE1	0.55748009
61	VRK2	0.54930920
62	PKN1	0.53916679
63	FLT3	0.53707273
64	PRKCQ	0.53537313
65	CAMK2A	0.53178433
66	NTRK2	0.52601868
67	CCNB1	0.51726687
68	BCR	0.51305234
69	MAP4K1	0.50832439
70	NTRK3	0.49544821
71	MKNK1	0.48451858
72	GRK5	0.48387524
73	CAMK1	0.48268973
74	TAF1	0.46941648
75	PRKACA	0.46099592
76	GRK7	0.45829944
77	RPS6KA5	0.45060413
78	PLK3	0.43853094
79	PRKCH	0.43848700
80	PRKCA	0.42888107
81	MAP2K2	0.42337314
82	SYK	0.41995250
83	NEK2	0.41259666
84	CSNK1A1	0.40877392
85	PLK4	0.40590967
86	IKBKB	0.39622045
87	NME1	0.38703368
88	FER	0.35405284
89	PRKCZ	0.35080591
90	PRKAA1	0.33937770
91	ITK	0.33030754
92	OBSCN	0.32135819
93	LCK	0.29254952
94	DYRK1A	0.28024812
95	PRKG1	0.27030642
96	MAPKAPK3	0.25452756
97	NLK	0.25449391
98	PIK3CG	0.25378835
99	STK16	0.25053111
100	MARK3	0.24163542

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.07135241
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.82632675
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.74372941
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.70046795
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.54989147
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.46991016
7	Butanoate metabolism_Homo sapiens_hsa00650	2.41182290
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.35472082
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.35415784
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.24305506
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.10673421
12	Caffeine metabolism_Homo sapiens_hsa00232	2.04900982
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.87568958
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.86225945
15	Parkinsons disease_Homo sapiens_hsa05012	1.80795535
16	Nicotine addiction_Homo sapiens_hsa05033	1.80031724
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79764484
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.77753303
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.75094915
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.74356015
21	Basal transcription factors_Homo sapiens_hsa03022	1.68990320
22	Protein export_Homo sapiens_hsa03060	1.58498978
23	Olfactory transduction_Homo sapiens_hsa04740	1.55013051
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47622337
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47245575
26	Homologous recombination_Homo sapiens_hsa03440	1.42003813
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.41463841
28	Morphine addiction_Homo sapiens_hsa05032	1.40477105
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.40344966
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.37761683
31	Taste transduction_Homo sapiens_hsa04742	1.32259332
32	RNA polymerase_Homo sapiens_hsa03020	1.31961567
33	Regulation of autophagy_Homo sapiens_hsa04140	1.25502666
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.23416041
35	RNA degradation_Homo sapiens_hsa03018	1.21430228
36	Propanoate metabolism_Homo sapiens_hsa00640	1.20221710
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19959477
38	Peroxisome_Homo sapiens_hsa04146	1.16923544
39	Huntingtons disease_Homo sapiens_hsa05016	1.16457080
40	ABC transporters_Homo sapiens_hsa02010	1.16252242
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.14878567
42	Alzheimers disease_Homo sapiens_hsa05010	1.11850494
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10865993
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.06601425
45	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01819289
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00843750
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97947258
48	One carbon pool by folate_Homo sapiens_hsa00670	0.95737059
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.95528747
50	Retinol metabolism_Homo sapiens_hsa00830	0.93438885
51	GABAergic synapse_Homo sapiens_hsa04727	0.93337567
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93129081
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.92713810
54	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.91886131
55	Serotonergic synapse_Homo sapiens_hsa04726	0.90052786
56	Insulin secretion_Homo sapiens_hsa04911	0.89070021
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86771501
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86070197
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85729905
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.85617258
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85400878
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.84879047
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.83182385
64	Sulfur metabolism_Homo sapiens_hsa00920	0.82024948
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.81340246
66	Circadian entrainment_Homo sapiens_hsa04713	0.76704192
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75100909
68	Metabolic pathways_Homo sapiens_hsa01100	0.72479871
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.70815611
70	Salivary secretion_Homo sapiens_hsa04970	0.66639044
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.64072544
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63629730
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.63240399
74	Purine metabolism_Homo sapiens_hsa00230	0.60889099
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.58482069
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57759427
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.57566747
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56928128
79	Non-homologous end-joining_Homo sapiens_hsa03450	0.53789948
80	Fatty acid degradation_Homo sapiens_hsa00071	0.52678443
81	Asthma_Homo sapiens_hsa05310	0.51259356
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46624843
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46094200
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45414314
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44858231
86	Proteasome_Homo sapiens_hsa03050	0.43494892
87	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43363321
88	Mineral absorption_Homo sapiens_hsa04978	0.42633629
89	Graft-versus-host disease_Homo sapiens_hsa05332	0.41985048
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41547012
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39888971
92	Ribosome_Homo sapiens_hsa03010	0.38685239
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36642152
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36333334
95	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.35681660
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.34284564
97	Circadian rhythm_Homo sapiens_hsa04710	0.28945280
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.28855444
99	Fatty acid elongation_Homo sapiens_hsa00062	0.27733230
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.27159306

FLJ42102

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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