FLOT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)4.58857573
2regulation of relaxation of muscle (GO:1901077)4.58581262
3positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.36346393
4regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.33666653
5sarcomere organization (GO:0045214)4.30498036
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.27216110
7regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.26311808
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.25709110
9regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.18771776
10regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.14508526
11synaptic vesicle maturation (GO:0016188)3.99112876
12Golgi transport vesicle coating (GO:0048200)3.91894212
13COPI coating of Golgi vesicle (GO:0048205)3.91894212
14cardiac myofibril assembly (GO:0055003)3.91484567
15protein localization to endosome (GO:0036010)3.85303429
16regulation of cell communication by electrical coupling (GO:0010649)3.83983363
17cell communication by electrical coupling (GO:0010644)3.81488319
18tricarboxylic acid cycle (GO:0006099)3.81121495
19cardiac muscle contraction (GO:0060048)3.75795937
20protein retention in ER lumen (GO:0006621)3.72987132
21cell communication involved in cardiac conduction (GO:0086065)3.57685906
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.57554750
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.55854235
24negative regulation of cell killing (GO:0031342)3.55854235
25regulation of synapse structural plasticity (GO:0051823)3.55648450
26negative regulation of potassium ion transmembrane transport (GO:1901380)3.52588275
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.48227976
28oxygen transport (GO:0015671)3.47749786
29activation of protein kinase A activity (GO:0034199)3.43585090
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38503862
31positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30165751
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.28995078
33NADH metabolic process (GO:0006734)3.27221260
34myofibril assembly (GO:0030239)3.27090672
35regulation of actin filament-based movement (GO:1903115)3.25067718
36actin-myosin filament sliding (GO:0033275)3.24326414
37muscle filament sliding (GO:0030049)3.24326414
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.23723899
39positive regulation of receptor recycling (GO:0001921)3.20603195
40regulation of calcium ion transmembrane transport (GO:1903169)3.18108410
41regulation of calcium ion transmembrane transporter activity (GO:1901019)3.18108410
42synaptic vesicle exocytosis (GO:0016079)3.16809958
43regulation of early endosome to late endosome transport (GO:2000641)3.14157419
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12557113
45negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10281733
46sarcoplasmic reticulum calcium ion transport (GO:0070296)3.10245192
47regulation of membrane repolarization (GO:0060306)3.09042784
48stress fiber assembly (GO:0043149)3.08989758
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04508189
50detection of temperature stimulus involved in sensory perception (GO:0050961)3.04275591
51detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.04275591
52barbed-end actin filament capping (GO:0051016)3.01429737
53positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.99807603
54regulation of striated muscle contraction (GO:0006942)2.98843335
55antigen processing and presentation of endogenous antigen (GO:0019883)2.98783483
56protein maturation by protein folding (GO:0022417)2.98236489
57regulation of short-term neuronal synaptic plasticity (GO:0048172)2.97418258
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.96820467
59positive regulation of potassium ion transmembrane transport (GO:1901381)2.96336760
60regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.95914611
61oxaloacetate metabolic process (GO:0006107)2.95778467
62potassium ion export (GO:0071435)2.95426859
63galactose catabolic process (GO:0019388)2.93047525
64negative regulation of microtubule polymerization (GO:0031115)2.90341346
65glutamate secretion (GO:0014047)2.89840973
66proline transport (GO:0015824)2.89129966
67regulation of synaptic vesicle exocytosis (GO:2000300)2.88445149
68regulation of synaptic vesicle transport (GO:1902803)2.88344041
69negative regulation of cell size (GO:0045792)2.86337277
70regulation of acyl-CoA biosynthetic process (GO:0050812)2.85905325
71positive regulation by symbiont of host defense response (GO:0052509)2.82416141
72modulation by symbiont of host defense response (GO:0052031)2.82416141
73modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82416141
74modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82416141
75positive regulation by organism of defense response of other organism involved in symbiotic interact2.82416141
76modulation by symbiont of host immune response (GO:0052553)2.82416141
77regulation of ARF protein signal transduction (GO:0032012)2.82290866
78regulation of extracellular matrix disassembly (GO:0010715)2.80575935
79regulation of cardiac muscle contraction (GO:0055117)2.80066585
80regulation of coenzyme metabolic process (GO:0051196)2.78893313
81regulation of cofactor metabolic process (GO:0051193)2.78893313
82regulation of cation channel activity (GO:2001257)2.78783362
83synaptic vesicle docking involved in exocytosis (GO:0016081)2.78642262
84cytoskeletal anchoring at plasma membrane (GO:0007016)2.77355276
85striated muscle contraction (GO:0006941)2.74831863
86positive regulation of protein dephosphorylation (GO:0035307)2.74078989
87membrane depolarization during action potential (GO:0086010)2.73944474
88detection of temperature stimulus (GO:0016048)2.70189767
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.69826528
90sodium ion export (GO:0071436)2.69516732
91negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.69312573
92positive regulation of Cdc42 GTPase activity (GO:0043089)2.68592943
93regulation of the force of heart contraction (GO:0002026)2.68406362
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67967906
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66991024
96positive regulation of cation channel activity (GO:2001259)2.65865851
97actomyosin structure organization (GO:0031032)2.64955607
98regulation of cardiac muscle cell contraction (GO:0086004)2.64668843
99cortical actin cytoskeleton organization (GO:0030866)2.62021542
100negative regulation of dendrite morphogenesis (GO:0050774)2.61832079
101detection of molecule of bacterial origin (GO:0032490)2.61773582
102ventricular cardiac muscle cell action potential (GO:0086005)2.61755984
103carnitine shuttle (GO:0006853)2.60321375
104regulation of amyloid precursor protein catabolic process (GO:1902991)2.59388007
105glucose 6-phosphate metabolic process (GO:0051156)2.58617622
106regulation of sodium ion transmembrane transporter activity (GO:2000649)2.56331144
107protein targeting to plasma membrane (GO:0072661)2.56160071
108antigen processing and presentation via MHC class Ib (GO:0002475)2.55258578
109bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53159482
110macrophage activation involved in immune response (GO:0002281)2.51752140
111negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.51666866
112negative regulation of calcium ion transmembrane transport (GO:1903170)2.51666866
113actin filament depolymerization (GO:0030042)2.50942458
114endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.50598945
115detection of other organism (GO:0098543)2.50412365
116vocalization behavior (GO:0071625)2.50125331
117basement membrane organization (GO:0071711)2.48882520
118negative regulation of erythrocyte differentiation (GO:0045647)2.48864915
119negative regulation of cation channel activity (GO:2001258)2.47809472
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47525289
121adenosine receptor signaling pathway (GO:0001973)2.47314045
122cellular potassium ion homeostasis (GO:0030007)2.46785291
123peripheral nervous system neuron development (GO:0048935)2.46391490
124modulation by symbiont of host cellular process (GO:0044068)2.46265088
125response to peptidoglycan (GO:0032494)2.45997858
126negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.45737454
127regulation of ARF GTPase activity (GO:0032312)2.45722160
128negative regulation of potassium ion transport (GO:0043267)2.44465919
129signal complex assembly (GO:0007172)2.44405758
130positive regulation of axon extension (GO:0045773)2.44375303
131regulation of defense response to virus by virus (GO:0050690)2.44302047
132detection of external biotic stimulus (GO:0098581)2.43935613
133detection of bacterium (GO:0016045)2.43826450
134skin morphogenesis (GO:0043589)2.43621235
135oxidative phosphorylation (GO:0006119)2.43539355
136locomotory exploration behavior (GO:0035641)2.42270795
137succinate metabolic process (GO:0006105)2.39747361
138actin-mediated cell contraction (GO:0070252)2.39227745
139pinocytosis (GO:0006907)2.39151490
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.38941745
141regulation of heart rate (GO:0002027)2.38757760
142regulation of heart contraction (GO:0008016)2.38705051
143neuronal action potential propagation (GO:0019227)2.38644579
144heart contraction (GO:0060047)2.38353233
145heart process (GO:0003015)2.38353233
146mannose metabolic process (GO:0006013)2.37529491
147neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.35867720
148negative regulation of ion transmembrane transporter activity (GO:0032413)2.35788795
149positive regulation of sodium ion transport (GO:0010765)2.35337020
150positive regulation of cellular amide metabolic process (GO:0034250)2.33460531
151regulation of protein dephosphorylation (GO:0035304)2.33344276
152fibril organization (GO:0097435)2.32985008
153regulation of T-helper 2 cell differentiation (GO:0045628)2.32319918
154response to laminar fluid shear stress (GO:0034616)2.31439459
155adherens junction assembly (GO:0034333)2.30174980
156negative regulation of necroptotic process (GO:0060546)2.28165815
157cortical cytoskeleton organization (GO:0030865)2.28052686
158germinal center formation (GO:0002467)2.27911154
159pentose-phosphate shunt (GO:0006098)2.27000230
160cell-cell junction maintenance (GO:0045217)2.25081027
161modulation by virus of host process (GO:0019054)2.24406254
162endothelial cell chemotaxis (GO:0035767)2.24353664
163semaphorin-plexin signaling pathway (GO:0071526)2.24256497
164regulation of necrotic cell death (GO:0010939)2.23880357
165focal adhesion assembly (GO:0048041)2.23331461
166cell-substrate adherens junction assembly (GO:0007045)2.23331461
167extracellular fibril organization (GO:0043206)2.21813898
168positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21633023
169activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.20189172
170positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.17998699
171vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.17495667
172activation of Rac GTPase activity (GO:0032863)2.16182896
173amyloid precursor protein catabolic process (GO:0042987)2.14311434
174negative regulation of glycoprotein metabolic process (GO:1903019)2.14029013
175regulation of necroptotic process (GO:0060544)2.11881451
176apoptotic process involved in morphogenesis (GO:0060561)2.11779980
177regulation of leukocyte degranulation (GO:0043300)2.11551711
178glycolytic process (GO:0006096)2.10601487
179regulation of myeloid leukocyte mediated immunity (GO:0002886)2.10453445
180layer formation in cerebral cortex (GO:0021819)2.10181871
181regulation of superoxide anion generation (GO:0032928)2.10072701
182regulation of regulated secretory pathway (GO:1903305)2.08328932
183modulation by virus of host morphology or physiology (GO:0019048)2.07837697
184negative regulation of necrotic cell death (GO:0060547)2.07658011
185actin filament polymerization (GO:0030041)2.06847138
186regulation of mammary gland epithelial cell proliferation (GO:0033599)2.06492215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.95713581
2EZH2_22144423_ChIP-Seq_EOC_Human3.33618876
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.94412136
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.79300692
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.76485758
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.71768632
7ZNF263_19887448_ChIP-Seq_K562_Human2.27067375
8LXR_22292898_ChIP-Seq_THP-1_Human2.23908304
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17924417
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10209199
11* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04671328
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91342230
13ELK3_25401928_ChIP-Seq_HUVEC_Human1.89228225
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86034838
15DNAJC2_21179169_ChIP-ChIP_NT2_Human1.81873151
16VDR_21846776_ChIP-Seq_THP-1_Human1.77553517
17SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.72779052
18IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72245282
19SCL_19346495_ChIP-Seq_HPC-7_Human1.68407502
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68397992
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67564658
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66134956
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.64240475
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.63345731
25* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62706257
26CLOCK_20551151_ChIP-Seq_293T_Human1.61691169
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61397348
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59764470
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59718605
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57917141
31KDM2B_26808549_Chip-Seq_DND41_Human1.57134813
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.56666737
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56553437
34* SPI1_23127762_ChIP-Seq_K562_Human1.56359371
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.54602405
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53613238
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51998294
38DROSHA_22980978_ChIP-Seq_HELA_Human1.51265685
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50877226
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49800939
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.49608444
42* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49264732
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48047757
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48047757
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.47745981
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.47463629
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45114379
48BCL6_27268052_Chip-Seq_Bcells_Human1.42037904
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37218768
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35434581
51* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34944539
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34243484
53* RUNX1_22412390_ChIP-Seq_EML_Mouse1.33536722
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33311017
55KDM2B_26808549_Chip-Seq_K562_Human1.32992472
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.32458499
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32174969
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31787273
59TBX20_22328084_ChIP-Seq_HEART_Mouse1.31403570
60TBX20_22080862_ChIP-Seq_HEART_Mouse1.31403570
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31338555
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.30926700
63* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30753169
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.29355818
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29353411
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27917933
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27324387
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27092606
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26270205
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25317785
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25085423
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25034116
73MAF_26560356_Chip-Seq_TH2_Human1.24831777
74CREB1_26743006_Chip-Seq_LNCaP_Human1.24661698
75VDR_24763502_ChIP-Seq_THP-1_Human1.24269393
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.23905957
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23310175
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22968856
79* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22579887
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22237849
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22209482
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22156710
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.21800092
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21728901
85CTCF_27219007_Chip-Seq_Bcells_Human1.21398873
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21067419
87UTX_26944678_Chip-Seq_JUKART_Human1.20000378
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19714594
89* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18524583
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18129839
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17695438
92RACK7_27058665_Chip-Seq_MCF-7_Human1.17581207
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17436629
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17087969
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16728734
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15522174
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15131782
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.15002435
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14892818
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14788316
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.14679931
102NCOR1_26117541_ChIP-Seq_K562_Human1.12635537
103P68_20966046_ChIP-Seq_HELA_Human1.12392260
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10988633
105GATA1_19941826_ChIP-Seq_K562_Human1.10937368
106ATF3_27146783_Chip-Seq_COLON_Human1.10085954
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09769375
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08830307
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08121654
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06465457
111SPI1_20517297_ChIP-Seq_HL60_Human1.06425026
112RXR_22158963_ChIP-Seq_LIVER_Mouse1.06405897
113SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06041153
114GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05944770
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05796057
116SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05625649
117SMC4_20622854_ChIP-Seq_HELA_Human1.04975774
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04801536
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04734450
120MYC_22102868_ChIP-Seq_BL_Human1.03971856
121SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03931074
122CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03260692
123TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03111169
124STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02689640
125MAF_26560356_Chip-Seq_TH1_Human1.02265964
126ERG_21242973_ChIP-ChIP_JURKAT_Human1.02216892
127CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02094728
128REST_21632747_ChIP-Seq_MESCs_Mouse1.01566480
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01299221
130TET1_21451524_ChIP-Seq_MESCs_Mouse1.00849364
131PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00708536
132TRIM28_21343339_ChIP-Seq_HEK293_Human0.99481685
133TP53_22127205_ChIP-Seq_IMR90_Human0.98597465
134CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98549733
135BCOR_27268052_Chip-Seq_Bcells_Human0.98538898
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.98444670
137CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98070803
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98022607
139GATA2_19941826_ChIP-Seq_K562_Human0.96240250
140CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96182879
141KDM2B_26808549_Chip-Seq_JURKAT_Human0.94799372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.93033655
2MP0000751_myopathy4.10696417
3MP0004084_abnormal_cardiac_muscle3.23070250
4MP0003646_muscle_fatigue3.15328677
5MP0002735_abnormal_chemical_nociception3.12065395
6MP0003191_abnormal_cellular_cholesterol2.97161378
7MP0004859_abnormal_synaptic_plasticity2.92516251
8MP0001968_abnormal_touch/_nociception2.90033859
9MP0000749_muscle_degeneration2.89823472
10MP0008260_abnormal_autophagy2.87713583
11MP0005451_abnormal_body_composition2.78778998
12MP0004215_abnormal_myocardial_fiber2.77796783
13MP0004858_abnormal_nervous_system2.77389610
14MP0003436_decreased_susceptibility_to2.74936976
15MP0002877_abnormal_melanocyte_morpholog2.72519439
16MP0009840_abnormal_foam_cell2.71359633
17MP0002736_abnormal_nociception_after2.57199920
18MP0004036_abnormal_muscle_relaxation2.54520592
19MP0004130_abnormal_muscle_cell2.36646886
20MP0005330_cardiomyopathy2.14579836
21MP0004510_myositis2.12788073
22MP0004270_analgesia2.06178416
23MP0002733_abnormal_thermal_nociception2.03208976
24MP0008775_abnormal_heart_ventricle1.99089053
25MP0002972_abnormal_cardiac_muscle1.93359168
26MP0000747_muscle_weakness1.87078055
27MP0006276_abnormal_autonomic_nervous1.85319602
28MP0004087_abnormal_muscle_fiber1.83786529
29MP0004484_altered_response_of1.77329904
30MP0001970_abnormal_pain_threshold1.77099467
31MP0003635_abnormal_synaptic_transmissio1.72731932
32MP0000604_amyloidosis1.72583670
33MP0002909_abnormal_adrenal_gland1.70893154
34MP0002734_abnormal_mechanical_nocicepti1.70748542
35MP0000343_altered_response_to1.65137673
36MP0005620_abnormal_muscle_contractility1.63057259
37MP0003279_aneurysm1.59750940
38MP0000858_altered_metastatic_potential1.59311875
39MP0002269_muscular_atrophy1.57357523
40MP0003091_abnormal_cell_migration1.55716287
41MP0005385_cardiovascular_system_phenoty1.55191345
42MP0001544_abnormal_cardiovascular_syste1.55191345
43MP0004145_abnormal_muscle_electrophysio1.53165705
44MP0001533_abnormal_skeleton_physiology1.52708950
45MP0000759_abnormal_skeletal_muscle1.52090868
46MP0003137_abnormal_impulse_conducting1.52090133
47MP0004085_abnormal_heartbeat1.51845990
48MP0002106_abnormal_muscle_physiology1.50470268
49MP0000750_abnormal_muscle_regeneration1.49817403
50MP0003690_abnormal_glial_cell1.45630960
51MP0001986_abnormal_taste_sensitivity1.43938527
52MP0001849_ear_inflammation1.41840779
53* MP0002419_abnormal_innate_immunity1.41717949
54MP0000920_abnormal_myelination1.38555595
55MP0005025_abnormal_response_to1.37631567
56MP0003123_paternal_imprinting1.36564135
57MP0003828_pulmonary_edema1.35344706
58MP0006036_abnormal_mitochondrial_physio1.34855384
59MP0000678_abnormal_parathyroid_gland1.34561692
60MP0006082_CNS_inflammation1.32399463
61MP0001958_emphysema1.32237690
62MP0008438_abnormal_cutaneous_collagen1.31502665
63MP0005257_abnormal_intraocular_pressure1.29579421
64MP0004947_skin_inflammation1.27472321
65MP0010630_abnormal_cardiac_muscle1.26141460
66MP0005369_muscle_phenotype1.21049144
67MP0002998_abnormal_bone_remodeling1.18683788
68MP0006138_congestive_heart_failure1.17587409
69MP0000013_abnormal_adipose_tissue1.17092081
70MP0003221_abnormal_cardiomyocyte_apopto1.15610458
71MP0002272_abnormal_nervous_system1.15412436
72MP0000003_abnormal_adipose_tissue1.14595447
73MP0009745_abnormal_behavioral_response1.13868178
74MP0002063_abnormal_learning/memory/cond1.12016485
75MP0000685_abnormal_immune_system1.11570757
76MP0008569_lethality_at_weaning1.11017445
77MP0003880_abnormal_central_pattern1.10072218
78MP0004233_abnormal_muscle_weight1.09454412
79MP0003329_amyloid_beta_deposits1.08412134
80MP0005000_abnormal_immune_tolerance1.07952208
81MP0004811_abnormal_neuron_physiology1.06803740
82MP0003453_abnormal_keratinocyte_physiol1.06318694
83MP0001348_abnormal_lacrimal_gland1.06296666
84MP0005375_adipose_tissue_phenotype1.06045275
85MP0005409_darkened_coat_color1.05262031
86MP0002064_seizures1.04929890
87MP0008874_decreased_physiological_sensi1.04646021
88MP0001501_abnormal_sleep_pattern1.04517347
89MP0008961_abnormal_basal_metabolism1.03511151
90MP0003634_abnormal_glial_cell1.03247105
91MP0003075_altered_response_to1.02341460
92MP0005076_abnormal_cell_differentiation1.01071089
93MP0005023_abnormal_wound_healing1.00018425
94MP0005666_abnormal_adipose_tissue0.99318732
95MP0001790_abnormal_immune_system0.98093126
96MP0005387_immune_system_phenotype0.98093126
97MP0003656_abnormal_erythrocyte_physiolo0.97838218
98MP0003566_abnormal_cell_adhesion0.96480627
99MP0005165_increased_susceptibility_to0.95126056
100MP0004185_abnormal_adipocyte_glucose0.94439667
101MP0005535_abnormal_body_temperature0.92873346
102MP0005390_skeleton_phenotype0.91099901
103MP0003879_abnormal_hair_cell0.89539900
104MP0001835_abnormal_antigen_presentation0.87283683
105MP0001542_abnormal_bone_strength0.86534556
106MP0000767_abnormal_smooth_muscle0.85814167
107MP0002067_abnormal_sensory_capabilities0.85595787
108MP0003045_fibrosis0.85318244
109MP0000230_abnormal_systemic_arterial0.85047235
110MP0009780_abnormal_chondrocyte_physiolo0.85002350
111MP0009046_muscle_twitch0.84567666
112MP0003172_abnormal_lysosome_physiology0.83899477
113MP0002184_abnormal_innervation0.82680789
114MP0005397_hematopoietic_system_phenotyp0.82035091
115MP0001545_abnormal_hematopoietic_system0.82035091
116MP0002723_abnormal_immune_serum0.82032381
117MP0002148_abnormal_hypersensitivity_rea0.80299923
118MP0003448_altered_tumor_morphology0.79894104
119MP0010368_abnormal_lymphatic_system0.79318974
120MP0002896_abnormal_bone_mineralization0.79165591
121MP0002572_abnormal_emotion/affect_behav0.79028041
122MP0003633_abnormal_nervous_system0.78693997
123MP0000733_abnormal_muscle_development0.78663456
124MP0009333_abnormal_splenocyte_physiolog0.78635740
125MP0010234_abnormal_vibrissa_follicle0.77702377
126MP0002089_abnormal_postnatal_growth/wei0.77335369
127MP0003303_peritoneal_inflammation0.76012535
128MP0005058_abnormal_lysosome_morphology0.75287392
129* MP0002420_abnormal_adaptive_immunity0.75247346
130* MP0001819_abnormal_immune_cell0.74978170
131MP0009278_abnormal_bone_marrow0.74856720
132MP0004147_increased_porphyrin_level0.72606425
133MP0001853_heart_inflammation0.71659355
134MP0002452_abnormal_antigen_presenting0.71124855
135MP0010155_abnormal_intestine_physiology0.71046490
136MP0005584_abnormal_enzyme/coenzyme_acti0.70229843
137MP0004808_abnormal_hematopoietic_stem0.70039340
138MP0005083_abnormal_biliary_tract0.69971035
139MP0000681_abnormal_thyroid_gland0.69328640
140MP0004272_abnormal_basement_membrane0.69155141
141MP0002332_abnormal_exercise_endurance0.68175293
142MP0005275_abnormal_skin_tensile0.68091027
143MP0004924_abnormal_behavior0.65950275
144MP0005386_behavior/neurological_phenoty0.65950275
145MP0005166_decreased_susceptibility_to0.65725143
146MP0003300_gastrointestinal_ulcer0.65025232
147MP0005464_abnormal_platelet_physiology0.64382257
148MP0006035_abnormal_mitochondrial_morpho0.64071520
149MP0005623_abnormal_meninges_morphology0.62908854
150MP0003183_abnormal_peptide_metabolism0.62619088
151MP0003724_increased_susceptibility_to0.62426566
152MP0001440_abnormal_grooming_behavior0.61424345
153MP0009785_altered_susceptibility_to0.61282623
154MP0003705_abnormal_hypodermis_morpholog0.60342259

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.68558372
2Myotonia (HP:0002486)4.05504251
3Asymmetric septal hypertrophy (HP:0001670)3.53472629
4Exercise-induced myalgia (HP:0003738)3.52878663
5Myokymia (HP:0002411)3.48885596
6Exercise-induced muscle cramps (HP:0003710)3.47405780
7Calf muscle hypertrophy (HP:0008981)3.45845114
8Pheochromocytoma (HP:0002666)3.44846491
9Ventricular tachycardia (HP:0004756)3.42704466
10Atrial fibrillation (HP:0005110)3.33744320
11Primary atrial arrhythmia (HP:0001692)3.26812865
12Neuroendocrine neoplasm (HP:0100634)3.26023141
13Palpitations (HP:0001962)3.23882127
14Supraventricular tachycardia (HP:0004755)3.21831134
15Supraventricular arrhythmia (HP:0005115)3.16883667
16Abnormality of the calf musculature (HP:0001430)3.12546510
17Bundle branch block (HP:0011710)3.06912549
18Muscle hypertrophy of the lower extremities (HP:0008968)3.06577758
19Lipoatrophy (HP:0100578)3.03883157
20Myoglobinuria (HP:0002913)3.02294663
21Abnormal gallbladder physiology (HP:0012438)3.00126898
22Cholecystitis (HP:0001082)3.00126898
23EMG: myopathic abnormalities (HP:0003458)2.99773770
24Hyporeflexia of lower limbs (HP:0002600)2.99737639
25Muscle fiber splitting (HP:0003555)2.99148668
26Neurofibrillary tangles (HP:0002185)2.96271643
27Premature rupture of membranes (HP:0001788)2.95444524
28Distal upper limb amyotrophy (HP:0007149)2.94910415
29Upper limb amyotrophy (HP:0009129)2.94910415
30Visual hallucinations (HP:0002367)2.93485602
31Ventricular fibrillation (HP:0001663)2.79805671
32Increased variability in muscle fiber diameter (HP:0003557)2.77052966
33Amyloidosis (HP:0011034)2.73231081
34Hypercortisolism (HP:0001578)2.67739692
35Cerebral inclusion bodies (HP:0100314)2.65159650
36Increased connective tissue (HP:0009025)2.64850751
37Abnormality of the left ventricular outflow tract (HP:0011103)2.62122347
38Subaortic stenosis (HP:0001682)2.62122347
39Ventricular arrhythmia (HP:0004308)2.59491058
40Abnormality of skeletal muscle fiber size (HP:0012084)2.58852949
41Abnormality of pain sensation (HP:0010832)2.58107920
42Impaired pain sensation (HP:0007328)2.58107920
43Difficulty climbing stairs (HP:0003551)2.56405681
44Obstructive sleep apnea (HP:0002870)2.54069843
45Syncope (HP:0001279)2.52748311
46Limb-girdle muscle atrophy (HP:0003797)2.51570774
47Abnormality of macrophages (HP:0004311)2.50272038
48Eczematoid dermatitis (HP:0000976)2.50134741
49Dysostosis multiplex (HP:0000943)2.49443130
50Prolonged QT interval (HP:0001657)2.49252964
51Hand muscle atrophy (HP:0009130)2.49208499
52Broad metatarsal (HP:0001783)2.49014811
53Neoplasm of the peripheral nervous system (HP:0100007)2.48412856
54Spinal canal stenosis (HP:0003416)2.41105431
55Axonal loss (HP:0003447)2.38598829
56Rapidly progressive (HP:0003678)2.38439733
57Achilles tendon contracture (HP:0001771)2.37140819
58Muscle stiffness (HP:0003552)2.36680621
59Abnormality of the vocal cords (HP:0008777)2.36345251
60Dilated cardiomyopathy (HP:0001644)2.35893634
61Protrusio acetabuli (HP:0003179)2.35706388
62Abnormality of liposaccharide metabolism (HP:0010968)2.35356526
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.35356526
64Abnormality of glycolipid metabolism (HP:0010969)2.35356526
65Right ventricular cardiomyopathy (HP:0011663)2.28754634
66Abnormal EKG (HP:0003115)2.28239992
67Neuronal loss in central nervous system (HP:0002529)2.26376623
68Type 1 muscle fiber predominance (HP:0003803)2.24867767
69Heart block (HP:0012722)2.20950589
70Systemic lupus erythematosus (HP:0002725)2.19678018
71Conjunctival hamartoma (HP:0100780)2.18959967
72Interstitial pulmonary disease (HP:0006530)2.18395213
73Abnormal atrioventricular conduction (HP:0005150)2.17637510
74Difficulty running (HP:0009046)2.16236472
75Bradycardia (HP:0001662)2.16059292
76Hypoventilation (HP:0002791)2.15783196
77Rhabdomyolysis (HP:0003201)2.15640105
78Abnormality of the Achilles tendon (HP:0005109)2.13438553
79Focal motor seizures (HP:0011153)2.13091738
80Myopathic facies (HP:0002058)2.12434309
81Nuclear cataract (HP:0100018)2.12410447
82Atrioventricular block (HP:0001678)2.12292772
83Urinary glycosaminoglycan excretion (HP:0003541)2.10659569
84Mucopolysacchariduria (HP:0008155)2.10659569
85Cervical subluxation (HP:0003308)2.09759759
86Abnormality of polysaccharide metabolism (HP:0011012)2.09658008
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09658008
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09658008
89Insomnia (HP:0100785)2.08705047
90Depression (HP:0000716)2.08492352
91Orchitis (HP:0100796)2.07287537
92Oligomenorrhea (HP:0000876)2.06875886
93Hemorrhage of the eye (HP:0011885)2.06446202
94Myositis (HP:0100614)2.06341082
95Distal arthrogryposis (HP:0005684)2.06332325
96Ragged-red muscle fibers (HP:0003200)2.05822449
97Hypothermia (HP:0002045)2.03958440
98Neoplasm of head and neck (HP:0012288)2.02852335
99Esophageal neoplasm (HP:0100751)2.02852335
100Foot dorsiflexor weakness (HP:0009027)2.02671251
101Recurrent abscess formation (HP:0002722)2.02179740
102Papilledema (HP:0001085)2.02105753
103Cellulitis (HP:0100658)2.01056565
104Failure to thrive in infancy (HP:0001531)1.99808557
105J-shaped sella turcica (HP:0002680)1.99240697
106Hepatocellular necrosis (HP:0001404)1.98941370
107Focal seizures (HP:0007359)1.98559147
108Hepatic necrosis (HP:0002605)1.97862442
109Loss of speech (HP:0002371)1.97848966
110Areflexia of lower limbs (HP:0002522)1.96566481
111Segmental peripheral demyelination/remyelination (HP:0003481)1.96079980
112Mildly elevated creatine phosphokinase (HP:0008180)1.96027551
113Action tremor (HP:0002345)1.95956930
114Cerebral hemorrhage (HP:0001342)1.95806451
115Striae distensae (HP:0001065)1.95141887
116Supranuclear gaze palsy (HP:0000605)1.94303422
117Abnormality of the foot musculature (HP:0001436)1.94017587
118Neoplasm of the adrenal gland (HP:0100631)1.93291461
119Increased muscle lipid content (HP:0009058)1.93059272
120Spinal rigidity (HP:0003306)1.92705764
121Growth hormone excess (HP:0000845)1.91986784
122Ankle clonus (HP:0011448)1.91578798
123Centrally nucleated skeletal muscle fibers (HP:0003687)1.91245800
124Dilatation of the ascending aorta (HP:0005111)1.89409660
125Peritonitis (HP:0002586)1.88606805
126Left ventricular hypertrophy (HP:0001712)1.88044041
127Abnormal mitochondria in muscle tissue (HP:0008316)1.86767515
128Mitral regurgitation (HP:0001653)1.86305886
129Distal lower limb muscle weakness (HP:0009053)1.85291021
130Purpura (HP:0000979)1.83578930
131Abnormality of complement system (HP:0005339)1.82221460
132Long toe (HP:0010511)1.81685400
133Polycythemia (HP:0001901)1.80079724
134Vertebral compression fractures (HP:0002953)1.79973385
135Sudden cardiac death (HP:0001645)1.79955904
136Deep venous thrombosis (HP:0002625)1.79826672
137Elevated erythrocyte sedimentation rate (HP:0003565)1.79290564
138Facial diplegia (HP:0001349)1.78461580
139Aneurysm (HP:0002617)1.78391985
140Enlarged penis (HP:0000040)1.78260474
141Decreased motor nerve conduction velocity (HP:0003431)1.78218258
142Bulbar palsy (HP:0001283)1.77670250
143Ulnar claw (HP:0001178)1.77342706
144Hypertriglyceridemia (HP:0002155)1.75976646
145Lower limb amyotrophy (HP:0007210)1.75920848
146Cerebral aneurysm (HP:0004944)1.75307030
147Atonic seizures (HP:0010819)1.74981604
148Apathy (HP:0000741)1.73369552
149Cholelithiasis (HP:0001081)1.73310415
150Anxiety (HP:0000739)1.73041151
151Frequent falls (HP:0002359)1.72745359
152Hyperparathyroidism (HP:0000843)1.71591358
153Vascular tortuosity (HP:0004948)1.70808053
154Broad face (HP:0000283)1.70671478
155Peripheral hypomyelination (HP:0007182)1.70627168
156Ulnar bowing (HP:0003031)1.70149110
157Torticollis (HP:0000473)1.69408119
158Wormian bones (HP:0002645)1.69083446
159Slow saccadic eye movements (HP:0000514)1.68549001
160Mitral stenosis (HP:0001718)1.67890176
161Recurrent gram-negative bacterial infections (HP:0005420)1.67508971
162Blue sclerae (HP:0000592)1.67405382
163Distal lower limb amyotrophy (HP:0008944)1.67374449
164Hyperacusis (HP:0010780)1.66871174
165Progressive neurologic deterioration (HP:0002344)1.66811924
166Shallow orbits (HP:0000586)1.66552371
167Diminished motivation (HP:0000745)1.65242348
168Stridor (HP:0010307)1.63917638
169Disproportionate tall stature (HP:0001519)1.63690830
170Arterial tortuosity (HP:0005116)1.61750981
171Thin bony cortex (HP:0002753)1.61465007
172Recurrent bacterial skin infections (HP:0005406)1.61444364
173Joint stiffness (HP:0001387)1.61329056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.11563695
2PKN23.08612925
3MAP3K123.02797810
4PRPF4B2.97492886
5TTN2.68865860
6TESK12.60670826
7MYLK2.59823093
8LMTK22.55044002
9MAP3K92.47120213
10KSR22.41941810
11PHKG12.11476812
12PHKG22.11476812
13TESK22.09099916
14ICK1.99596961
15IRAK31.89977792
16MINK11.87409632
17SMG11.85076301
18SIK11.80267547
19NTRK11.75788483
20FLT31.75203372
21TAOK21.71364625
22MAPKAPK31.64251379
23ARAF1.55809721
24DAPK21.52054735
25RIPK41.49740623
26ERN11.49344283
27GRK51.48699281
28NTRK31.45247002
29KIT1.42787147
30CAMKK21.41019785
31SCYL21.40228775
32RET1.39287577
33TAOK11.37016019
34EPHA21.36913714
35CAMKK11.36800386
36MAP3K31.35610149
37FGFR41.31436116
38MAP2K31.30430825
39NEK11.28913182
40MARK21.24055309
41MAP3K11.23402457
42MUSK1.22679857
43RIPK11.22446879
44DAPK31.21239726
45BCKDK1.20736221
46MOS1.20519633
47MAP2K41.20348995
48ILK1.16191569
49TIE11.15110272
50MAP3K111.13820969
51TYK21.13187962
52MATK1.12758850
53PRKD21.10395684
54PINK11.10338779
55PAK41.08450483
56PAK61.08385189
57OBSCN1.08291608
58IRAK41.06467081
59CDK191.06466335
60PIM21.06448093
61PDK31.06079211
62PDK41.06079211
63DAPK11.04855032
64CAMK11.03335009
65PTK60.97462536
66MAP3K20.97245495
67EEF2K0.96575643
68CDC42BPA0.96177442
69LRRK20.95891878
70DMPK0.94529895
71LIMK10.94529160
72RAF10.93722006
73MAP3K60.93463750
74PRKD30.91197489
75PTK2B0.90897033
76MAP4K10.90507354
77STK380.87433682
78RPS6KA20.86923672
79EPHA30.84052582
80PRKG20.83563552
81CSK0.82301394
82IRAK20.82051429
83TBK10.81800281
84MAP2K10.80928202
85MAP2K60.79188434
86ZAP700.78109507
87EPHB10.77259678
88MAP3K70.77241821
89GRK60.74917261
90FES0.74499544
91TNK20.74030757
92MAP2K70.72527791
93DDR20.70864059
94PRKCH0.70823262
95PAK30.69884613
96HIPK20.69712365
97MAPK120.67438796
98BRAF0.66053361
99MAP3K40.65908821
100PIK3CA0.65018771
101CDK150.63156425
102BMX0.63128702
103CDK11A0.63093449
104KDR0.62769974
105TGFBR20.59214596
106LATS20.59056842
107PDK10.58480967
108GRK70.58472281
109CDK140.58313983
110CDK50.58113665
111TGFBR10.58060891
112CDK180.57678917
113FER0.55645384
114PAK10.54190469
115JAK20.53344676
116MST1R0.52759661
117CAMK40.52017819
118TYRO30.51974400
119PRKD10.51664853
120TNIK0.51563210
121SYK0.50271647
122UHMK10.50212525
123NME20.49887310
124MAP3K130.49499649
125MAPKAPK50.49218180
126PDGFRA0.48882279
127MAP3K140.48800236
128PDPK10.48696731
129JAK10.48576579
130SIK30.48300538
131ROCK20.48300026
132MAP3K80.48038815
133ABL20.47697088
134SIK20.46569174
135JAK30.46392788
136MAPK130.45665039
137KSR10.45563838
138DYRK1B0.45559425
139MAPK110.45244154
140CAMK2G0.45192770
141TEC0.45146876
142BLK0.44795048
143SGK30.42995954
144PTK20.42991319
145MAPK40.42581534
146ROCK10.42198197
147MAP3K50.40615654
148MAPK70.40524541

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.65940096
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49575470
3Synaptic vesicle cycle_Homo sapiens_hsa047212.42137436
4Cardiac muscle contraction_Homo sapiens_hsa042602.39800221
5Other glycan degradation_Homo sapiens_hsa005112.29904874
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21440876
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.13927642
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07341206
9Dilated cardiomyopathy_Homo sapiens_hsa054142.02533096
10Olfactory transduction_Homo sapiens_hsa047401.89205143
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.89010677
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.88601465
13Parkinsons disease_Homo sapiens_hsa050121.83926190
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74854524
15Prion diseases_Homo sapiens_hsa050201.55887979
16Oxidative phosphorylation_Homo sapiens_hsa001901.54068860
17Circadian entrainment_Homo sapiens_hsa047131.50001672
18Fructose and mannose metabolism_Homo sapiens_hsa000511.48532952
19Pentose phosphate pathway_Homo sapiens_hsa000301.38089214
20Alzheimers disease_Homo sapiens_hsa050101.36900236
21Long-term potentiation_Homo sapiens_hsa047201.31325920
22Insulin secretion_Homo sapiens_hsa049111.30153702
23Cholinergic synapse_Homo sapiens_hsa047251.28727573
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25870560
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25523882
26Dopaminergic synapse_Homo sapiens_hsa047281.24932746
27Lysosome_Homo sapiens_hsa041421.22974758
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.20772490
29Gastric acid secretion_Homo sapiens_hsa049711.19483465
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19076336
31Oxytocin signaling pathway_Homo sapiens_hsa049211.18556223
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14729047
33Pancreatic cancer_Homo sapiens_hsa052121.14574536
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12779733
35* Insulin signaling pathway_Homo sapiens_hsa049101.12741759
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12359409
37Calcium signaling pathway_Homo sapiens_hsa040201.12187872
38VEGF signaling pathway_Homo sapiens_hsa043701.12181137
39GnRH signaling pathway_Homo sapiens_hsa049121.12008382
40Glioma_Homo sapiens_hsa052141.10631566
41Salivary secretion_Homo sapiens_hsa049701.10234434
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.10064552
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.08503330
44B cell receptor signaling pathway_Homo sapiens_hsa046621.08010241
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07330778
46Notch signaling pathway_Homo sapiens_hsa043301.05974946
47Carbon metabolism_Homo sapiens_hsa012001.05772680
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05042305
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03280984
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02553104
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02258007
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01152763
53Thyroid cancer_Homo sapiens_hsa052161.00075215
54Gap junction_Homo sapiens_hsa045401.00034999
55Morphine addiction_Homo sapiens_hsa050320.98206197
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96667304
57Staphylococcus aureus infection_Homo sapiens_hsa051500.96393255
58Acute myeloid leukemia_Homo sapiens_hsa052210.95203850
59Platelet activation_Homo sapiens_hsa046110.94962439
60Pertussis_Homo sapiens_hsa051330.94939949
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94859609
62Renin secretion_Homo sapiens_hsa049240.94191421
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92792420
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92208153
65Biosynthesis of amino acids_Homo sapiens_hsa012300.92095228
66Hepatitis C_Homo sapiens_hsa051600.91717421
67Amphetamine addiction_Homo sapiens_hsa050310.89716286
68Renal cell carcinoma_Homo sapiens_hsa052110.89578632
69GABAergic synapse_Homo sapiens_hsa047270.88649153
70Toxoplasmosis_Homo sapiens_hsa051450.87682553
71Estrogen signaling pathway_Homo sapiens_hsa049150.86728456
72HIF-1 signaling pathway_Homo sapiens_hsa040660.86515249
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85222323
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.84986288
75Type II diabetes mellitus_Homo sapiens_hsa049300.83892290
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83035633
77cAMP signaling pathway_Homo sapiens_hsa040240.82352916
78Huntingtons disease_Homo sapiens_hsa050160.82228997
79Glucagon signaling pathway_Homo sapiens_hsa049220.82056733
80ErbB signaling pathway_Homo sapiens_hsa040120.81965810
81Collecting duct acid secretion_Homo sapiens_hsa049660.81651017
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81138508
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80236946
84Apoptosis_Homo sapiens_hsa042100.79601375
85Taste transduction_Homo sapiens_hsa047420.79411576
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.79276586
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.78687717
88Chemokine signaling pathway_Homo sapiens_hsa040620.78583554
89Galactose metabolism_Homo sapiens_hsa000520.78022149
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.77991789
91Salmonella infection_Homo sapiens_hsa051320.77843526
92TNF signaling pathway_Homo sapiens_hsa046680.77329725
93Glutamatergic synapse_Homo sapiens_hsa047240.76615411
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76477498
95Insulin resistance_Homo sapiens_hsa049310.76420400
96Malaria_Homo sapiens_hsa051440.76041083
97Viral myocarditis_Homo sapiens_hsa054160.74527383
98Hepatitis B_Homo sapiens_hsa051610.73929500
99Vibrio cholerae infection_Homo sapiens_hsa051100.73765218
100Sulfur relay system_Homo sapiens_hsa041220.71109416
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70647939
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69996090
103Propanoate metabolism_Homo sapiens_hsa006400.69702044
104Focal adhesion_Homo sapiens_hsa045100.69329731
105Pyruvate metabolism_Homo sapiens_hsa006200.69288544
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68929610
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68882807
108Serotonergic synapse_Homo sapiens_hsa047260.68663381
109Influenza A_Homo sapiens_hsa051640.67848477
110AMPK signaling pathway_Homo sapiens_hsa041520.67135540
111Prolactin signaling pathway_Homo sapiens_hsa049170.66744418
112Leishmaniasis_Homo sapiens_hsa051400.66532128
113Fatty acid degradation_Homo sapiens_hsa000710.66068203
114Proteoglycans in cancer_Homo sapiens_hsa052050.65499027
115Endocytosis_Homo sapiens_hsa041440.64256677
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63056248
117Amoebiasis_Homo sapiens_hsa051460.62983331
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61769163
119Chronic myeloid leukemia_Homo sapiens_hsa052200.60805033
120Shigellosis_Homo sapiens_hsa051310.60689010
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58651128
122Phagosome_Homo sapiens_hsa041450.58524542
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57840053
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.56454335
125Bladder cancer_Homo sapiens_hsa052190.55998497
126Inositol phosphate metabolism_Homo sapiens_hsa005620.55972029
127Non-small cell lung cancer_Homo sapiens_hsa052230.55364450
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54347131
129mTOR signaling pathway_Homo sapiens_hsa041500.54088727
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53948692
131Endometrial cancer_Homo sapiens_hsa052130.53310830
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53090631
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53076416
134Osteoclast differentiation_Homo sapiens_hsa043800.52993684
135Long-term depression_Homo sapiens_hsa047300.52249837
136Tuberculosis_Homo sapiens_hsa051520.51707029
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51289497
138Nicotine addiction_Homo sapiens_hsa050330.51205683
139Rap1 signaling pathway_Homo sapiens_hsa040150.50986707
140Choline metabolism in cancer_Homo sapiens_hsa052310.49845750
141Cocaine addiction_Homo sapiens_hsa050300.49596176
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.48207503

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