FLOT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.21128544
2negative regulation of cell killing (GO:0031342)6.21128544
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.99330851
4positive regulation by symbiont of host defense response (GO:0052509)5.75172457
5modulation by symbiont of host defense response (GO:0052031)5.75172457
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.75172457
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.75172457
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.75172457
9modulation by symbiont of host immune response (GO:0052553)5.75172457
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.69539367
11antigen processing and presentation of endogenous antigen (GO:0019883)5.66599038
12positive regulation of gamma-delta T cell activation (GO:0046645)5.65236560
13neutrophil activation involved in immune response (GO:0002283)5.27071364
14detection of other organism (GO:0098543)5.25155960
15leukocyte aggregation (GO:0070486)5.18873069
16detection of bacterium (GO:0016045)5.17803797
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.07775258
18leukocyte migration involved in inflammatory response (GO:0002523)4.66913600
19plasma membrane repair (GO:0001778)4.64489524
20negative regulation of erythrocyte differentiation (GO:0045647)4.57080081
21response to peptidoglycan (GO:0032494)4.51581918
22macrophage activation involved in immune response (GO:0002281)4.50071656
23regulation of B cell receptor signaling pathway (GO:0050855)4.48852504
24detection of external biotic stimulus (GO:0098581)4.26230880
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.20881463
26respiratory burst (GO:0045730)4.20682498
27synaptic vesicle maturation (GO:0016188)4.20595757
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.17150863
29response to interleukin-15 (GO:0070672)3.99480293
30regulation of gamma-delta T cell activation (GO:0046643)3.99406411
31cellular extravasation (GO:0045123)3.98515394
32neutrophil activation (GO:0042119)3.98350093
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.97200279
34response to host immune response (GO:0052572)3.97200279
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.96153601
36regulation of interferon-beta biosynthetic process (GO:0045357)3.90912573
37regulation of mast cell degranulation (GO:0043304)3.90897725
38immunoglobulin mediated immune response (GO:0016064)3.80756218
39negative regulation of leukocyte mediated immunity (GO:0002704)3.80621061
40detection of temperature stimulus (GO:0016048)3.78973372
41detection of temperature stimulus involved in sensory perception (GO:0050961)3.76426985
42detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.76426985
43detection of biotic stimulus (GO:0009595)3.75435032
44regulation of myeloid leukocyte mediated immunity (GO:0002886)3.72773395
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.71572056
46response to host (GO:0075136)3.71572056
47response to host defenses (GO:0052200)3.71572056
48proline transport (GO:0015824)3.71086139
49regulation of gamma-delta T cell differentiation (GO:0045586)3.70654539
50detection of molecule of bacterial origin (GO:0032490)3.66168158
51cell communication by electrical coupling (GO:0010644)3.65231708
52negative regulation of microtubule polymerization (GO:0031115)3.64115166
53negative regulation of phagocytosis (GO:0050765)3.63471937
54negative regulation of cell size (GO:0045792)3.60231388
55regulation of leukocyte degranulation (GO:0043300)3.57021850
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.56680690
57granulocyte activation (GO:0036230)3.55446332
58activation of protein kinase A activity (GO:0034199)3.52821772
59production of molecular mediator involved in inflammatory response (GO:0002532)3.50273838
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.49997309
61regulation of mast cell activation involved in immune response (GO:0033006)3.49848325
62negative regulation of interleukin-12 production (GO:0032695)3.48668693
63B cell receptor signaling pathway (GO:0050853)3.47392029
64cellular response to interleukin-15 (GO:0071350)3.47267347
65response to muramyl dipeptide (GO:0032495)3.47128319
66cell communication involved in cardiac conduction (GO:0086065)3.46867333
67antigen processing and presentation via MHC class Ib (GO:0002475)3.41518376
68sodium ion export (GO:0071436)3.40432287
69alanine transport (GO:0032328)3.37884942
70positive thymic T cell selection (GO:0045059)3.37555578
71myeloid cell activation involved in immune response (GO:0002275)3.34807439
72positive regulation of B cell differentiation (GO:0045579)3.33606399
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.30284057
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.30066981
75regulation of B cell differentiation (GO:0045577)3.28517119
76tricarboxylic acid cycle (GO:0006099)3.28275316
77negative thymic T cell selection (GO:0045060)3.27278362
78regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.26305205
79barbed-end actin filament capping (GO:0051016)3.23871549
80regulation of early endosome to late endosome transport (GO:2000641)3.23349000
81regulation of T-helper 2 cell differentiation (GO:0045628)3.22490458
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.22318689
83carnitine shuttle (GO:0006853)3.21751803
84cellular response to type I interferon (GO:0071357)3.21221193
85type I interferon signaling pathway (GO:0060337)3.21221193
86macrophage activation (GO:0042116)3.19836632
87response to type I interferon (GO:0034340)3.17993686
88regulation of regulated secretory pathway (GO:1903305)3.17931962
89cell migration in hindbrain (GO:0021535)3.17891234
90negative regulation of T cell mediated immunity (GO:0002710)3.16314396
91germinal center formation (GO:0002467)3.16050782
92positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.11989770
93negative T cell selection (GO:0043383)3.11886536
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11863545
95regulation of NFAT protein import into nucleus (GO:0051532)3.08934976
96negative regulation of potassium ion transmembrane transport (GO:1901380)3.08138856
97microglial cell activation (GO:0001774)3.07278271
98regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06841379
99positive regulation of mast cell activation (GO:0033005)3.05601277
100regulation of T cell tolerance induction (GO:0002664)3.04660919
101thymic T cell selection (GO:0045061)3.04626398
102negative regulation of type 2 immune response (GO:0002829)3.04286154
103neutrophil mediated immunity (GO:0002446)3.03938195
104glutamate secretion (GO:0014047)3.03113823
105leukocyte degranulation (GO:0043299)3.03047814
106regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.02624213
107fatty acid transmembrane transport (GO:1902001)2.98997979
108regulation of synapse structural plasticity (GO:0051823)2.98969697
109T cell selection (GO:0045058)2.97768964
1103-UTR-mediated mRNA stabilization (GO:0070935)2.97154507
111negative regulation of innate immune response (GO:0045824)2.96531264
112negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.95753815
113protein targeting to plasma membrane (GO:0072661)2.95473853
114synaptic vesicle docking involved in exocytosis (GO:0016081)2.95289327
115regulation of tolerance induction (GO:0002643)2.94757546
116defense response to protozoan (GO:0042832)2.94240886
117regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.93433531
118positive regulation of axon extension (GO:0045773)2.93077385
119positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.91948075
120regulation of mast cell activation (GO:0033003)2.91330511
121negative regulation of dendrite morphogenesis (GO:0050774)2.90220065
122B cell mediated immunity (GO:0019724)2.89879089
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88400218
124regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84414680
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.81147477
126regulation of natural killer cell mediated immunity (GO:0002715)2.80926938
127regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.80926938
128negative regulation of glycoprotein biosynthetic process (GO:0010561)2.80637346
129tolerance induction (GO:0002507)2.80322557
130positive regulation of Cdc42 GTPase activity (GO:0043089)2.79804872
131positive regulation of mast cell activation involved in immune response (GO:0033008)2.79315426
132positive regulation of mast cell degranulation (GO:0043306)2.79315426
133regulation of translational termination (GO:0006449)2.78155778
134regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.77609138
135axon cargo transport (GO:0008088)2.77020793
136layer formation in cerebral cortex (GO:0021819)2.75849303
137negative regulation of interleukin-6 production (GO:0032715)2.75706740
138lysine metabolic process (GO:0006553)2.75204660
139lysine catabolic process (GO:0006554)2.75204660
140regulation of synaptic vesicle exocytosis (GO:2000300)2.74418870
141positive regulation of cellular amide metabolic process (GO:0034250)2.73964022
142negative regulation of T-helper cell differentiation (GO:0045623)2.73838148
143negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73838148
144COPI coating of Golgi vesicle (GO:0048205)2.73128583
145Golgi transport vesicle coating (GO:0048200)2.73128583
146regulation of fatty acid oxidation (GO:0046320)2.71887443
147regulation of fatty acid beta-oxidation (GO:0031998)2.71883467
148interferon-gamma-mediated signaling pathway (GO:0060333)2.71000996
149positive T cell selection (GO:0043368)2.69973648
150lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69817264
151synaptic vesicle exocytosis (GO:0016079)2.69516964
152oxaloacetate metabolic process (GO:0006107)2.68804083
153locomotory exploration behavior (GO:0035641)2.68025701
154stress fiber assembly (GO:0043149)2.67242267
155low-density lipoprotein particle clearance (GO:0034383)2.62582331
156actin filament capping (GO:0051693)2.61393500
157tricarboxylic acid metabolic process (GO:0072350)2.60838636
158negative regulation of protein polymerization (GO:0032272)2.59130799
159positive regulation of potassium ion transmembrane transport (GO:1901381)2.58619161
160regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.58223653
161NADH metabolic process (GO:0006734)2.58222498
162sarcomere organization (GO:0045214)2.57997356
163membrane repolarization (GO:0086009)2.57382256
1642-oxoglutarate metabolic process (GO:0006103)2.54504541
165membrane depolarization during action potential (GO:0086010)2.53769895
166negative regulation of actin filament polymerization (GO:0030837)2.52314832
167regulation of sodium ion transmembrane transporter activity (GO:2000649)2.52304092
168regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49342191
169pentose-phosphate shunt (GO:0006098)2.47842431
170antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.47619213
171neurofilament cytoskeleton organization (GO:0060052)2.46966625
172regulation of synaptic vesicle transport (GO:1902803)2.46860539
173regulation of membrane repolarization (GO:0060306)2.43095844
174positive regulation of fatty acid beta-oxidation (GO:0032000)2.42278181
175antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.42070210
176antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.42070210
177retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39273168
178cellular potassium ion homeostasis (GO:0030007)2.38187742
179regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34062570
180alpha-linolenic acid metabolic process (GO:0036109)2.33519849
181cardiac muscle contraction (GO:0060048)2.33003861
182mitochondrion transport along microtubule (GO:0047497)2.32417883
183establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.32417883
184killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.31379809
185disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.31379809
186negative regulation of fatty acid transport (GO:2000192)2.30162981
187potassium ion export (GO:0071435)2.30101149
188regulation of cholesterol storage (GO:0010885)2.30072664
189carnitine transmembrane transport (GO:1902603)2.29277108
190activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.28191285
191regulation of calcium ion transmembrane transporter activity (GO:1901019)2.28159214
192regulation of calcium ion transmembrane transport (GO:1903169)2.28159214
193NADPH regeneration (GO:0006740)2.27715751
194membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.27490312
195positive regulation of vesicle fusion (GO:0031340)2.26145933
196neurotransmitter secretion (GO:0007269)2.25836638
197regulation of potassium ion transmembrane transporter activity (GO:1901016)2.24675734
198apoptotic cell clearance (GO:0043277)2.24664689
199cardiac myofibril assembly (GO:0055003)2.24145110
200bundle of His cell to Purkinje myocyte communication (GO:0086069)2.23886635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.40237865
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.36363589
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.25974876
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.08521914
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97596714
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.80408631
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.63383624
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.58310302
9ZNF263_19887448_ChIP-Seq_K562_Human2.56088654
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54374831
11LXR_22292898_ChIP-Seq_THP-1_Human2.51092725
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.51082570
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.47916356
14VDR_24763502_ChIP-Seq_THP-1_Human2.44421168
15MAF_26560356_Chip-Seq_TH1_Human2.39331601
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.38747267
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32548620
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31256174
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26308713
20UTX_26944678_Chip-Seq_JUKART_Human2.23553317
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22868070
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17292263
23SPI1_23547873_ChIP-Seq_NB4_Human2.16241965
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12301109
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12121857
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.12005840
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.11724358
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.10288529
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05191387
30CLOCK_20551151_ChIP-Seq_293T_Human2.03062333
31* ELK3_25401928_ChIP-Seq_HUVEC_Human2.02877606
32KDM2B_26808549_Chip-Seq_K562_Human1.96912400
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96373451
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.93852535
35SCL_19346495_ChIP-Seq_HPC-7_Human1.93539513
36KDM2B_26808549_Chip-Seq_DND41_Human1.93360948
37MAF_26560356_Chip-Seq_TH2_Human1.91717602
38* RXR_22158963_ChIP-Seq_LIVER_Mouse1.89370347
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.87048821
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86220424
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.84921993
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81137880
43RACK7_27058665_Chip-Seq_MCF-7_Human1.80964850
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78305640
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78293189
46RUNX_20019798_ChIP-Seq_JUKART_Human1.71682795
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68762507
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67497033
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.66861461
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66350618
51* MYB_26560356_Chip-Seq_TH2_Human1.61121787
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.60707318
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.60234672
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58680177
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58155434
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57130416
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56073444
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55741769
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55405132
60MYB_26560356_Chip-Seq_TH1_Human1.54058987
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.52893727
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.52357211
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51278877
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50285062
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49582054
66ATF3_27146783_Chip-Seq_COLON_Human1.48948317
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48372825
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47706963
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47688287
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46028621
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45640852
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45253075
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44546032
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43044809
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42738264
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40726949
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39802935
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39771643
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.39368259
80P68_20966046_ChIP-Seq_HELA_Human1.39107323
81NCOR1_26117541_ChIP-Seq_K562_Human1.37922063
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36784896
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36181019
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35591775
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35325318
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34280681
87LXR_22158963_ChIP-Seq_LIVER_Mouse1.34153167
88* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34013634
89RARB_27405468_Chip-Seq_BRAIN_Mouse1.33237679
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32414084
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31242863
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30642310
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29657639
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26932953
95CTCF_27219007_Chip-Seq_Bcells_Human1.26757462
96CREB1_26743006_Chip-Seq_LNCaP_Human1.24825479
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24191516
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23744335
99MYC_22102868_ChIP-Seq_BL_Human1.22306962
100VDR_21846776_ChIP-Seq_THP-1_Human1.21158642
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20903880
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.20780130
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.20778544
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20583398
105BCL6_27268052_Chip-Seq_Bcells_Human1.20017223
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19699009
107DROSHA_22980978_ChIP-Seq_HELA_Human1.19224475
108TCF7_22412390_ChIP-Seq_EML_Mouse1.18953640
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18880144
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18814297
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18332053
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.17650243
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17320633
114TBX20_22328084_ChIP-Seq_HEART_Mouse1.17035076
115TBX20_22080862_ChIP-Seq_HEART_Mouse1.17035076
116BCOR_27268052_Chip-Seq_Bcells_Human1.16430402
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.15561192
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15076969
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14549319
120SMC4_20622854_ChIP-Seq_HELA_Human1.13274872
121IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13085047
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13079880
123SPI1_23127762_ChIP-Seq_K562_Human1.12554653
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12474327
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11689961
126* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11525995
127TP53_22127205_ChIP-Seq_IMR90_Human1.11350546
128REST_18959480_ChIP-ChIP_MESCs_Mouse1.11153017
129NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09658711
130* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09452237
131* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09358930
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07791046
133* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07688012
134GATA3_27048872_Chip-Seq_THYMUS_Human1.07562184
135EP300_21415370_ChIP-Seq_HL-1_Mouse1.06950689
136MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05951349
137SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04739952
138SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03182915
139TRIM28_21343339_ChIP-Seq_HEK293_Human1.02955971
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02900060
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02656899
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02341117
143CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01313453
144CIITA_25753668_ChIP-Seq_RAJI_Human1.00481403
145* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99948265
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99283596
147CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98853791
148JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98664278
149EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98356662
150RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98022836
151EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98022836
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.97242900
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95417040
154EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95191830
155GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95016027
156* TP63_22573176_ChIP-Seq_HFKS_Human0.94613044
157MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94166603
158TP53_23651856_ChIP-Seq_MEFs_Mouse0.93927961
159SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93816786
160GATA1_19941826_ChIP-Seq_K562_Human0.93142844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.48091783
2MP0004858_abnormal_nervous_system4.47823617
3MP0003436_decreased_susceptibility_to4.25468395
4MP0002837_dystrophic_cardiac_calcinosis3.58071073
5MP0002735_abnormal_chemical_nociception3.39598096
6MP0001835_abnormal_antigen_presentation3.27121246
7MP0004859_abnormal_synaptic_plasticity3.15833996
8MP0001968_abnormal_touch/_nociception3.04583239
9MP0002419_abnormal_innate_immunity3.00891559
10MP0000751_myopathy2.96266674
11MP0003705_abnormal_hypodermis_morpholog2.90186149
12MP0005025_abnormal_response_to2.81861025
13MP0004270_analgesia2.76648549
14MP0008260_abnormal_autophagy2.65444210
15MP0009278_abnormal_bone_marrow2.59779412
16MP0001800_abnormal_humoral_immune2.59775576
17MP0005387_immune_system_phenotype2.58680550
18MP0001790_abnormal_immune_system2.58680550
19MP0005000_abnormal_immune_tolerance2.54856912
20MP0002736_abnormal_nociception_after2.53678974
21MP0005671_abnormal_response_to2.49392391
22MP0000685_abnormal_immune_system2.48194788
23MP0002420_abnormal_adaptive_immunity2.43758430
24MP0002733_abnormal_thermal_nociception2.42153123
25MP0001819_abnormal_immune_cell2.41154242
26MP0005464_abnormal_platelet_physiology2.36712254
27MP0009785_altered_susceptibility_to2.35572532
28MP0002723_abnormal_immune_serum2.35418108
29MP0002132_abnormal_respiratory_system2.33942823
30MP0003329_amyloid_beta_deposits2.32775197
31MP0003763_abnormal_thymus_physiology2.31932424
32MP0002452_abnormal_antigen_presenting2.28146043
33MP0004130_abnormal_muscle_cell2.22372547
34MP0005451_abnormal_body_composition2.19606500
35MP0004084_abnormal_cardiac_muscle2.19242057
36MP0000749_muscle_degeneration2.11712715
37MP0002398_abnormal_bone_marrow2.04512526
38MP0000465_gastrointestinal_hemorrhage2.01505155
39MP0001533_abnormal_skeleton_physiology2.00209622
40MP0008438_abnormal_cutaneous_collagen1.99138533
41MP0002396_abnormal_hematopoietic_system1.96163606
42MP0006082_CNS_inflammation1.95203501
43MP0002734_abnormal_mechanical_nocicepti1.94915068
44MP0002405_respiratory_system_inflammati1.91062469
45MP0000716_abnormal_immune_system1.87664199
46MP0001970_abnormal_pain_threshold1.87374245
47MP0002909_abnormal_adrenal_gland1.86387713
48MP0004087_abnormal_muscle_fiber1.80540039
49MP0003566_abnormal_cell_adhesion1.78989068
50MP0003279_aneurysm1.77927765
51MP0002148_abnormal_hypersensitivity_rea1.74940460
52MP0009333_abnormal_splenocyte_physiolog1.74669422
53MP0002269_muscular_atrophy1.73584448
54MP0009840_abnormal_foam_cell1.72050099
55MP0010155_abnormal_intestine_physiology1.71144969
56MP0004947_skin_inflammation1.70257571
57MP0001545_abnormal_hematopoietic_system1.70081547
58MP0005397_hematopoietic_system_phenotyp1.70081547
59MP0002722_abnormal_immune_system1.69236209
60MP0005083_abnormal_biliary_tract1.66452276
61MP0004036_abnormal_muscle_relaxation1.65234945
62MP0000689_abnormal_spleen_morphology1.64155009
63MP0000858_altered_metastatic_potential1.63442137
64MP0000747_muscle_weakness1.62693693
65MP0000604_amyloidosis1.62463395
66MP0000703_abnormal_thymus_morphology1.60776870
67MP0003828_pulmonary_edema1.60098026
68MP0002429_abnormal_blood_cell1.58309610
69MP0000013_abnormal_adipose_tissue1.51736867
70MP0001845_abnormal_inflammatory_respons1.51545930
71MP0003866_abnormal_defecation1.50694607
72MP0003646_muscle_fatigue1.47807482
73MP0003635_abnormal_synaptic_transmissio1.44710329
74MP0003183_abnormal_peptide_metabolism1.44195795
75MP0004510_myositis1.43209276
76MP0004381_abnormal_hair_follicle1.43017609
77MP0004215_abnormal_myocardial_fiber1.41965390
78MP0002972_abnormal_cardiac_muscle1.40807182
79MP0000759_abnormal_skeletal_muscle1.40292132
80MP0001851_eye_inflammation1.39689336
81MP0006276_abnormal_autonomic_nervous1.39125795
82MP0003172_abnormal_lysosome_physiology1.39108422
83MP0004811_abnormal_neuron_physiology1.38618486
84MP0008961_abnormal_basal_metabolism1.38115304
85MP0005330_cardiomyopathy1.37510945
86MP0008775_abnormal_heart_ventricle1.30383520
87MP0008469_abnormal_protein_level1.29896727
88MP0000750_abnormal_muscle_regeneration1.28279597
89MP0001958_emphysema1.26872082
90MP0003075_altered_response_to1.24957626
91MP0003656_abnormal_erythrocyte_physiolo1.23789497
92MP0009780_abnormal_chondrocyte_physiolo1.23714936
93MP0003303_peritoneal_inflammation1.23417859
94MP0003221_abnormal_cardiomyocyte_apopto1.22192126
95MP0002277_abnormal_respiratory_mucosa1.21596916
96MP0001849_ear_inflammation1.19636259
97MP0005620_abnormal_muscle_contractility1.19301946
98MP0005385_cardiovascular_system_phenoty1.17499366
99MP0001544_abnormal_cardiovascular_syste1.17499366
100MP0005275_abnormal_skin_tensile1.15825156
101MP0000343_altered_response_to1.13631615
102MP0001348_abnormal_lacrimal_gland1.12929382
103MP0004233_abnormal_muscle_weight1.12836736
104MP0010630_abnormal_cardiac_muscle1.12801825
105MP0010329_abnormal_lipoprotein_level1.11091711
106MP0003633_abnormal_nervous_system1.08104556
107MP0002106_abnormal_muscle_physiology1.07094811
108MP0003300_gastrointestinal_ulcer1.06223333
109MP0000490_abnormal_crypts_of1.06150008
110MP0005623_abnormal_meninges_morphology1.05520772
111MP0005167_abnormal_blood-brain_barrier1.04260633
112MP0003806_abnormal_nucleotide_metabolis1.01490108
113MP0004145_abnormal_muscle_electrophysio1.00411585
114MP0005670_abnormal_white_adipose0.99935930
115MP0009764_decreased_sensitivity_to0.99233823
116MP0003690_abnormal_glial_cell0.98829765
117MP0002998_abnormal_bone_remodeling0.96477181
118MP0010352_gastrointestinal_tract_polyps0.94852213
119MP0008004_abnormal_stomach_pH0.94404837
120MP0002063_abnormal_learning/memory/cond0.94381669
121MP0003191_abnormal_cellular_cholesterol0.92836060
122MP0006138_congestive_heart_failure0.92201203
123MP0001873_stomach_inflammation0.91321524
124MP0002184_abnormal_innervation0.91283968
125MP0005310_abnormal_salivary_gland0.90994173
126MP0008874_decreased_physiological_sensi0.90189645
127MP0005076_abnormal_cell_differentiation0.89767091
128MP0002139_abnormal_hepatobiliary_system0.88754414
129MP0005023_abnormal_wound_healing0.88598736
130MP0005058_abnormal_lysosome_morphology0.88393839
131MP0005666_abnormal_adipose_tissue0.88020654
132MP0004085_abnormal_heartbeat0.86854743
133MP0002822_catalepsy0.85962705
134MP0003878_abnormal_ear_physiology0.85391741
135MP0005377_hearing/vestibular/ear_phenot0.85391741
136MP0005365_abnormal_bile_salt0.85122244
137MP0005584_abnormal_enzyme/coenzyme_acti0.84870171
138MP0005319_abnormal_enzyme/_coenzyme0.84805424
139MP0005390_skeleton_phenotype0.84755670
140MP0005369_muscle_phenotype0.83636621
141MP0001756_abnormal_urination0.83033987
142MP0000003_abnormal_adipose_tissue0.82161914
143MP0004808_abnormal_hematopoietic_stem0.82149054
144MP0004883_abnormal_blood_vessel0.81339211
145MP0005375_adipose_tissue_phenotype0.81167681
146MP0002166_altered_tumor_susceptibility0.80184862
147MP0000955_abnormal_spinal_cord0.80032613
148MP0003091_abnormal_cell_migration0.79796089
149MP0002118_abnormal_lipid_homeostasis0.79653620
150MP0002089_abnormal_postnatal_growth/wei0.79551535
151MP0005535_abnormal_body_temperature0.78343724
152MP0005164_abnormal_response_to0.78054919
153MP0009763_increased_sensitivity_to0.77063743
154MP0000358_abnormal_cell_content/0.76121513
155MP0001853_heart_inflammation0.74868785
156MP0002078_abnormal_glucose_homeostasis0.74849243
157MP0006036_abnormal_mitochondrial_physio0.74706819
158MP0004185_abnormal_adipocyte_glucose0.74539025
159MP0001663_abnormal_digestive_system0.74375689
160MP0003137_abnormal_impulse_conducting0.74337752
161MP0002064_seizures0.74079992
162MP0000534_abnormal_ureter_morphology0.72409709
163MP0005166_decreased_susceptibility_to0.72304795
164MP0000678_abnormal_parathyroid_gland0.71809465
165MP0003631_nervous_system_phenotype0.70822533
166MP0002877_abnormal_melanocyte_morpholog0.69996072
167MP0008569_lethality_at_weaning0.69087819
168MP0003448_altered_tumor_morphology0.65088610
169MP0002933_joint_inflammation0.63338775
170MP0005075_abnormal_melanosome_morpholog0.62837233
171MP0004264_abnormal_extraembryonic_tissu0.62653222
172MP0002653_abnormal_ependyma_morphology0.60809410
173MP0002019_abnormal_tumor_incidence0.58963706
174MP0003795_abnormal_bone_structure0.57341786
175MP0009765_abnormal_xenobiotic_induced0.55979959
176MP0001915_intracranial_hemorrhage0.54564267

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.72217432
2Recurrent abscess formation (HP:0002722)5.54641005
3Recurrent bacterial skin infections (HP:0005406)5.28168212
4Myositis (HP:0100614)5.08259801
5Abnormality of macrophages (HP:0004311)5.06207813
6Recurrent gram-negative bacterial infections (HP:0005420)4.54509801
7Orchitis (HP:0100796)4.48522312
8Chronic obstructive pulmonary disease (HP:0006510)4.44254172
9Obstructive lung disease (HP:0006536)4.44254172
10Stomatitis (HP:0010280)4.03379205
11Elevated erythrocyte sedimentation rate (HP:0003565)4.02148386
12Optic neuritis (HP:0100653)3.87634773
13Retrobulbar optic neuritis (HP:0100654)3.87634773
14Meningitis (HP:0001287)3.85558123
15Myokymia (HP:0002411)3.84362466
16Gastrointestinal infarctions (HP:0005244)3.84129476
17Increased IgE level (HP:0003212)3.82743271
18Cellulitis (HP:0100658)3.79279848
19Recurrent fungal infections (HP:0002841)3.78810537
20Mediastinal lymphadenopathy (HP:0100721)3.77606888
21Hypochromic microcytic anemia (HP:0004840)3.72978661
22Prolonged bleeding time (HP:0003010)3.66891308
23Spontaneous hematomas (HP:0007420)3.47210157
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.47057243
25Recurrent skin infections (HP:0001581)3.40492470
26Myotonia (HP:0002486)3.34008056
27Gingivitis (HP:0000230)3.32635240
28Urticaria (HP:0001025)3.29200458
29Hypochromic anemia (HP:0001931)3.27540968
30Pheochromocytoma (HP:0002666)3.26979301
31Encephalitis (HP:0002383)3.10818696
32Sudden death (HP:0001699)3.08222900
33Abnormality of the lower motor neuron (HP:0002366)3.06689851
34Gastrointestinal inflammation (HP:0004386)3.06335404
35Chest pain (HP:0100749)3.01021103
36Abnormality of the heme biosynthetic pathway (HP:0010472)2.97551656
37Recurrent cutaneous fungal infections (HP:0011370)2.97443796
38Chronic mucocutaneous candidiasis (HP:0002728)2.97443796
39Neuroendocrine neoplasm (HP:0100634)2.92604742
40Hyporeflexia of lower limbs (HP:0002600)2.92583708
41Abnormality of pain sensation (HP:0010832)2.92369003
42Impaired pain sensation (HP:0007328)2.92369003
43Petechiae (HP:0000967)2.91753465
44Hand muscle atrophy (HP:0009130)2.90704608
45Inflammation of the large intestine (HP:0002037)2.90193058
46Protrusio acetabuli (HP:0003179)2.89825775
47Keratoconjunctivitis sicca (HP:0001097)2.89078216
48Upper limb amyotrophy (HP:0009129)2.88557861
49Distal upper limb amyotrophy (HP:0007149)2.88557861
50Episodic fever (HP:0001954)2.88429825
51Hypercortisolism (HP:0001578)2.87977246
52Asymmetric septal hypertrophy (HP:0001670)2.87740357
53Epistaxis (HP:0000421)2.86662239
54Myoglobinuria (HP:0002913)2.84772367
55Action tremor (HP:0002345)2.84498406
56Vasculitis (HP:0002633)2.83602279
57Increased connective tissue (HP:0009025)2.79997004
58Panhypogammaglobulinemia (HP:0003139)2.73473822
59Gingival bleeding (HP:0000225)2.71861232
60Ulnar claw (HP:0001178)2.59945954
61Recurrent viral infections (HP:0004429)2.59655696
62Exercise-induced muscle cramps (HP:0003710)2.58781296
63Cerebral aneurysm (HP:0004944)2.56599446
64Keratoconjunctivitis (HP:0001096)2.55946736
65Osteomyelitis (HP:0002754)2.55854115
66Amyloidosis (HP:0011034)2.54408918
67Agammaglobulinemia (HP:0004432)2.53037682
68Polycythemia (HP:0001901)2.50661805
69Difficulty running (HP:0009046)2.50227305
70Sepsis (HP:0100806)2.48987144
71Colitis (HP:0002583)2.48562711
72Difficulty climbing stairs (HP:0003551)2.47458730
73Pustule (HP:0200039)2.46204390
74Termporal pattern (HP:0011008)2.46068286
75Insidious onset (HP:0003587)2.46068286
76Increased variability in muscle fiber diameter (HP:0003557)2.44300625
77Exercise-induced myalgia (HP:0003738)2.44037994
78Microcytic anemia (HP:0001935)2.43999764
79Purpura (HP:0000979)2.43139972
80Palpitations (HP:0001962)2.42631931
81Achilles tendon contracture (HP:0001771)2.40549000
82Bundle branch block (HP:0011710)2.40244001
83Abnormality of the vocal cords (HP:0008777)2.39813462
84Arterial thrombosis (HP:0004420)2.36938292
85Granulocytopenia (HP:0001913)2.36351567
86Anorexia (HP:0002039)2.35996524
87Abnormality of the Achilles tendon (HP:0005109)2.35472716
88Leukocytosis (HP:0001974)2.34033476
89Metaphyseal cupping (HP:0003021)2.33608066
90Long toe (HP:0010511)2.33116288
91Neoplasm of the peripheral nervous system (HP:0100007)2.33022540
92Abnormal platelet volume (HP:0011876)2.32716324
93Ventricular fibrillation (HP:0001663)2.32371325
94Visual hallucinations (HP:0002367)2.31007828
95Hypertensive crisis (HP:0100735)2.30727828
96Hemoptysis (HP:0002105)2.29168688
97Muscle stiffness (HP:0003552)2.29013341
98Increased IgM level (HP:0003496)2.27436708
99Pulmonary embolism (HP:0002204)2.25266968
100Hepatosplenomegaly (HP:0001433)2.24455254
101Pulmonary infiltrates (HP:0002113)2.23223796
102Polygenic inheritance (HP:0010982)2.22482444
103EMG: myopathic abnormalities (HP:0003458)2.20815157
104Foot dorsiflexor weakness (HP:0009027)2.19826516
105Distal arthrogryposis (HP:0005684)2.19788230
106Abnormality of skeletal muscle fiber size (HP:0012084)2.19622074
107Abnormality of the peritoneum (HP:0002585)2.18886634
108Supranuclear gaze palsy (HP:0000605)2.18563348
109Striae distensae (HP:0001065)2.18267285
110Neonatal onset (HP:0003623)2.17171549
111Type 1 muscle fiber predominance (HP:0003803)2.14055756
112Hypoventilation (HP:0002791)2.13325152
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12935708
114Lymphopenia (HP:0001888)2.11619870
115Ventricular tachycardia (HP:0004756)2.11219894
116Skin ulcer (HP:0200042)2.11137137
117Rapidly progressive (HP:0003678)2.10715116
118Abnormal gallbladder physiology (HP:0012438)2.09977794
119Cholecystitis (HP:0001082)2.09977794
120Segmental peripheral demyelination/remyelination (HP:0003481)2.09628125
121Hammertoe (HP:0001765)2.09554771
122Hypergammaglobulinemia (HP:0010702)2.08513873
123Increased serum ferritin (HP:0003281)2.05542305
124T lymphocytopenia (HP:0005403)2.05217300
125Ankle clonus (HP:0011448)2.04959087
126Slow saccadic eye movements (HP:0000514)2.04541787
127Broad metatarsal (HP:0001783)2.03322668
128Ankle contracture (HP:0006466)2.03216487
129Premature loss of primary teeth (HP:0006323)2.02814596
130Torticollis (HP:0000473)2.02647560
131Abnormality of T cells (HP:0002843)2.01928717
132Enlarged penis (HP:0000040)2.01821398
133Abnormality of the foot musculature (HP:0001436)2.01525508
134Oligomenorrhea (HP:0000876)2.01505824
135Muscle fiber splitting (HP:0003555)2.01473373
136Abnormality of cells of the lymphoid lineage (HP:0012140)1.98862707
137Deep venous thrombosis (HP:0002625)1.98846444
138Viral hepatitis (HP:0006562)1.98351022
139EMG: neuropathic changes (HP:0003445)1.95948742
140Papilledema (HP:0001085)1.94303173
141Acne (HP:0001061)1.93278956
142Interstitial pulmonary disease (HP:0006530)1.93244632
143Growth hormone excess (HP:0000845)1.92242950
144Hyperacusis (HP:0010780)1.90843245
145Lymphangioma (HP:0100764)1.90077874
146Papilloma (HP:0012740)1.89231905
147Verrucae (HP:0200043)1.89231905
148Rhabdomyolysis (HP:0003201)1.89167073
149Bowel diverticulosis (HP:0005222)1.89062464
150Abnormality of iron homeostasis (HP:0011031)1.89000424
151Peritonitis (HP:0002586)1.88952402
152Centrally nucleated skeletal muscle fibers (HP:0003687)1.88578944
153Conjunctival hamartoma (HP:0100780)1.87958304
154Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87932734
155Increased cerebral lipofuscin (HP:0011813)1.87843598
156Insomnia (HP:0100785)1.87177547
157Right ventricular cardiomyopathy (HP:0011663)1.86076254
158Abnormal hemoglobin (HP:0011902)1.86076191
159Abnormality of T cell number (HP:0011839)1.84555487
160Depression (HP:0000716)1.84389081
161Loss of speech (HP:0002371)1.84276250
162Hypermelanotic macule (HP:0001034)1.84243194
163Limb-girdle muscle atrophy (HP:0003797)1.84020063
164Craniofacial dystonia (HP:0012179)1.82865489
165Gastrointestinal dysmotility (HP:0002579)1.82837728
166Neoplasm of the adrenal gland (HP:0100631)1.82788702
167Frequent falls (HP:0002359)1.82500599
168Skin rash (HP:0000988)1.82135956
169Abnormality of the pleura (HP:0002103)1.81703207
170Hypertriglyceridemia (HP:0002155)1.80666620
171Nasal polyposis (HP:0100582)1.80211907
172Failure to thrive in infancy (HP:0001531)1.79786122
173Acute hepatic failure (HP:0006554)1.79606125
174Abnormality of T cell physiology (HP:0011840)1.79116354
175Resting tremor (HP:0002322)1.78949142
176Ventricular arrhythmia (HP:0004308)1.77532429
177Urinary urgency (HP:0000012)1.77503032
178Ketoacidosis (HP:0001993)1.76450774
179Focal seizures (HP:0007359)1.76098836
180Vertebral compression fractures (HP:0002953)1.75020931
181Focal dystonia (HP:0004373)1.74172029
182Primary atrial arrhythmia (HP:0001692)1.72972245
183Cholelithiasis (HP:0001081)1.71474630
184Dysmetric saccades (HP:0000641)1.70874518
185Spinal canal stenosis (HP:0003416)1.70033665
186Wrist flexion contracture (HP:0001239)1.69200111
187Lipoatrophy (HP:0100578)1.68646414
188Atrial fibrillation (HP:0005110)1.67178771
189Axonal loss (HP:0003447)1.67172676
190Supraventricular arrhythmia (HP:0005115)1.67020489
191Athetosis (HP:0002305)1.66449484
192Hamartoma of the eye (HP:0010568)1.66437693
193Supraventricular tachycardia (HP:0004755)1.65866911
194Aneurysm (HP:0002617)1.65321132
195Bladder diverticulum (HP:0000015)1.65071103
196Shallow orbits (HP:0000586)1.64989403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.17904790
2MAP4K13.69960854
3PKN23.03497550
4MAP3K92.85870747
5KSR22.82382492
6NTRK12.79701163
7NEK12.65378248
8FES2.62691602
9IRAK42.61447753
10PRPF4B2.59725383
11RIPK12.53812847
12TYK22.51253809
13TNK22.51179167
14TTN2.41602786
15LMTK22.32539426
16GRK62.30518132
17MINK12.29158793
18CSK2.22027140
19ERN12.19179691
20LATS22.18451152
21SMG12.11565284
22LIMK11.98426278
23DAPK21.97520171
24ZAP701.94354850
25PHKG21.91404824
26PHKG11.91404824
27TESK11.81293949
28PRKD31.79971592
29MAP3K31.79855940
30ARAF1.73197862
31MAP3K21.71722585
32PAK61.70728143
33JAK31.70404647
34CAMKK11.67993370
35BTK1.66225374
36RET1.65550169
37HCK1.58211713
38SIK31.52270825
39SCYL21.51659579
40PDGFRA1.49809161
41MAPKAPK31.42095798
42MAP3K131.38242591
43NTRK31.35660171
44GRK51.35600206
45PRKD21.33607120
46FGR1.30792833
47MARK21.29986998
48MAP2K41.27552767
49SYK1.22941365
50TBK11.22431194
51TAOK11.19924623
52MAP2K11.19351776
53STK101.14412428
54MAP3K121.14179630
55MATK1.10419727
56MAP3K11.07741525
57PTK21.07162810
58RPS6KA21.06479169
59LYN1.06218763
60MAP3K111.03124639
61CAMKK21.02204231
62DAPK10.98198704
63TAOK20.97665768
64MARK10.97588351
65LCK0.96760291
66TESK20.96254778
67PTK60.95230588
68SIK20.95003384
69IKBKE0.94149152
70MAP3K140.93918622
71LRRK20.92807289
72EEF2K0.92276449
73PDK30.91987872
74PDK40.91987872
75MAP3K40.91507024
76CSF1R0.90989152
77TXK0.90971490
78STK380.90608126
79PTK2B0.89952743
80MAP3K60.88837282
81YES10.88597922
82DAPK30.88404022
83BCKDK0.87374119
84PAK30.85177417
85ITK0.83848138
86MAP3K70.83218607
87DYRK1B0.82712250
88MYLK0.81548104
89FER0.81546532
90ICK0.81365816
91CDK190.80858183
92CAMK1D0.78490457
93DMPK0.72738072
94CDK120.72673522
95MARK30.72548599
96RIPK40.71563781
97ILK0.70771822
98PRKCH0.70247942
99ALK0.69873051
100FLT30.69423312
101HIPK20.68542481
102IRAK20.67359979
103MAP2K30.66237440
104PIM20.66200951
105FGFR40.65336543
106MAPK120.65217727
107CDK140.64947139
108MAP3K80.64437229
109* FYN0.63208934
110CDK50.61548441
111SIK10.60801261
112RPS6KC10.57261235
113RPS6KL10.57261235
114BMX0.54548593
115CDC42BPA0.54526972
116EPHB10.54370473
117RAF10.54356542
118SGK30.53237563
119PDPK10.53160433
120IRAK10.52102436
121KSR10.50513055
122MAP3K50.49314887
123ROCK10.49034308
124JAK20.48938185
125CDK150.48077290
126PRKG20.47897846
127STK110.47393672
128CDK180.47169340
129DDR20.47056064
130PDK10.46650736
131CAMK1G0.44847897
132MAP3K100.44121329
133MAP2K20.43257986
134TEC0.43206777
135KDR0.43003308
136PAK40.42117306
137MAP2K60.40956053
138UHMK10.40927781
139CAMK40.40116897
140CDK11A0.39966209
141KIT0.39943342
142RPS6KA60.39066008
143MAPKAPK20.39051927
144CDK40.38948004
145BRSK10.38910106
146FGFR30.38633613
147MAPK70.38003849
148EPHA30.37410797
149PRKCQ0.36986455
150STK240.35618212
151PRKCZ0.35567934
152PINK10.35554473
153IKBKB0.34333072
154FGFR10.33816060
155BLK0.32834079
156JAK10.31914819
157PRKD10.31548987

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.16680502
2Osteoclast differentiation_Homo sapiens_hsa043802.85566286
3Leishmaniasis_Homo sapiens_hsa051402.82764392
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.59792529
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58241348
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.54797534
7Staphylococcus aureus infection_Homo sapiens_hsa051502.44927595
8B cell receptor signaling pathway_Homo sapiens_hsa046622.42277411
9Synaptic vesicle cycle_Homo sapiens_hsa047212.27465793
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.26848285
11Acute myeloid leukemia_Homo sapiens_hsa052212.26803394
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.23134826
13Primary immunodeficiency_Homo sapiens_hsa053401.99425184
14Tuberculosis_Homo sapiens_hsa051521.95550683
15Nitrogen metabolism_Homo sapiens_hsa009101.91630258
16Allograft rejection_Homo sapiens_hsa053301.82882005
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82811117
18Graft-versus-host disease_Homo sapiens_hsa053321.81300042
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77402618
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73500710
21Autoimmune thyroid disease_Homo sapiens_hsa053201.72943965
22Malaria_Homo sapiens_hsa051441.69149712
23Measles_Homo sapiens_hsa051621.59475006
24Chemokine signaling pathway_Homo sapiens_hsa040621.58073935
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55126794
26T cell receptor signaling pathway_Homo sapiens_hsa046601.53819790
27Fatty acid degradation_Homo sapiens_hsa000711.51255928
28Carbon metabolism_Homo sapiens_hsa012001.50475929
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.50085485
30Hematopoietic cell lineage_Homo sapiens_hsa046401.43356605
31Other glycan degradation_Homo sapiens_hsa005111.43053718
32Toxoplasmosis_Homo sapiens_hsa051451.43047918
33Olfactory transduction_Homo sapiens_hsa047401.42483855
34Antigen processing and presentation_Homo sapiens_hsa046121.39811466
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.36093071
36Arginine biosynthesis_Homo sapiens_hsa002201.35325851
37Influenza A_Homo sapiens_hsa051641.35314821
38Pancreatic cancer_Homo sapiens_hsa052121.32403442
39Herpes simplex infection_Homo sapiens_hsa051681.32375436
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.31580494
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29437706
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27356094
43Notch signaling pathway_Homo sapiens_hsa043301.27023175
44* Insulin signaling pathway_Homo sapiens_hsa049101.23361430
45Dilated cardiomyopathy_Homo sapiens_hsa054141.23053499
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.20495963
47Platelet activation_Homo sapiens_hsa046111.20445785
48Type I diabetes mellitus_Homo sapiens_hsa049401.20249004
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20079493
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19937825
51Shigellosis_Homo sapiens_hsa051311.18371901
52Glioma_Homo sapiens_hsa052141.17014875
53Hepatitis B_Homo sapiens_hsa051611.16533416
54Insulin secretion_Homo sapiens_hsa049111.15199898
55Pyruvate metabolism_Homo sapiens_hsa006201.12316410
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.12268117
57Hepatitis C_Homo sapiens_hsa051601.11836189
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11603286
59Fatty acid metabolism_Homo sapiens_hsa012121.11456621
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10390886
61Legionellosis_Homo sapiens_hsa051341.08976612
62Insulin resistance_Homo sapiens_hsa049311.07366184
63Type II diabetes mellitus_Homo sapiens_hsa049301.06704946
64Bile secretion_Homo sapiens_hsa049761.05589287
65Cardiac muscle contraction_Homo sapiens_hsa042601.05086991
66African trypanosomiasis_Homo sapiens_hsa051431.04855943
67Renal cell carcinoma_Homo sapiens_hsa052111.04572397
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04481306
69Biosynthesis of amino acids_Homo sapiens_hsa012301.02664791
70Glucagon signaling pathway_Homo sapiens_hsa049221.01536462
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01292451
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99972853
73VEGF signaling pathway_Homo sapiens_hsa043700.99735846
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99142372
75Cholinergic synapse_Homo sapiens_hsa047250.98920403
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97323756
77PPAR signaling pathway_Homo sapiens_hsa033200.96847487
78Dopaminergic synapse_Homo sapiens_hsa047280.95609779
79Gap junction_Homo sapiens_hsa045400.95089443
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.94546572
81TNF signaling pathway_Homo sapiens_hsa046680.93855379
82Bladder cancer_Homo sapiens_hsa052190.93834851
83Long-term potentiation_Homo sapiens_hsa047200.93095550
84GnRH signaling pathway_Homo sapiens_hsa049120.92884156
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92622540
86mTOR signaling pathway_Homo sapiens_hsa041500.92245418
87Apoptosis_Homo sapiens_hsa042100.92067094
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91512097
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90131914
90Thyroid cancer_Homo sapiens_hsa052160.89832268
91Propanoate metabolism_Homo sapiens_hsa006400.89187039
92Estrogen signaling pathway_Homo sapiens_hsa049150.88319167
93Circadian entrainment_Homo sapiens_hsa047130.87585203
94Gastric acid secretion_Homo sapiens_hsa049710.84654007
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.83514556
96Prion diseases_Homo sapiens_hsa050200.82735074
97Colorectal cancer_Homo sapiens_hsa052100.82339603
98Pertussis_Homo sapiens_hsa051330.81325944
99Endometrial cancer_Homo sapiens_hsa052130.81070027
100Amoebiasis_Homo sapiens_hsa051460.79731156
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79240251
102Oxytocin signaling pathway_Homo sapiens_hsa049210.78395212
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77778207
104Galactose metabolism_Homo sapiens_hsa000520.77354411
105Starch and sucrose metabolism_Homo sapiens_hsa005000.76914437
106Choline metabolism in cancer_Homo sapiens_hsa052310.76830349
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74683243
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74427942
109Endocytosis_Homo sapiens_hsa041440.73541053
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73076321
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72924295
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72477551
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.71281088
114AMPK signaling pathway_Homo sapiens_hsa041520.69437159
115Focal adhesion_Homo sapiens_hsa045100.69157394
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69034561
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68635758
118Epstein-Barr virus infection_Homo sapiens_hsa051690.68044520
119Salivary secretion_Homo sapiens_hsa049700.67923690
120Chronic myeloid leukemia_Homo sapiens_hsa052200.67809627
121Inositol phosphate metabolism_Homo sapiens_hsa005620.66885272
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.66600319
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65798769
124Asthma_Homo sapiens_hsa053100.65311984
125FoxO signaling pathway_Homo sapiens_hsa040680.64940217
126HIF-1 signaling pathway_Homo sapiens_hsa040660.64896285
127HTLV-I infection_Homo sapiens_hsa051660.64772220
128ErbB signaling pathway_Homo sapiens_hsa040120.64295287
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64193844
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64076772
131Rap1 signaling pathway_Homo sapiens_hsa040150.64027097
132Thyroid hormone synthesis_Homo sapiens_hsa049180.63901854
133Viral carcinogenesis_Homo sapiens_hsa052030.63538095
134Salmonella infection_Homo sapiens_hsa051320.63436577
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63168545
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62067136
137Non-small cell lung cancer_Homo sapiens_hsa052230.61831862
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.61648775
139Lysosome_Homo sapiens_hsa041420.61540043
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60463413
141Prolactin signaling pathway_Homo sapiens_hsa049170.59779383
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59508640
143Phagosome_Homo sapiens_hsa041450.59028066
144Fructose and mannose metabolism_Homo sapiens_hsa000510.58638884
145Dorso-ventral axis formation_Homo sapiens_hsa043200.58129061
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.55904028
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55390030
148Butanoate metabolism_Homo sapiens_hsa006500.54912027
149Pentose phosphate pathway_Homo sapiens_hsa000300.54592308
150Proteoglycans in cancer_Homo sapiens_hsa052050.54383107
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54278975
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53450909
153Renin secretion_Homo sapiens_hsa049240.53299209
154GABAergic synapse_Homo sapiens_hsa047270.53043226
155Tryptophan metabolism_Homo sapiens_hsa003800.51771161
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.50769263
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50629086
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48685671
159Vibrio cholerae infection_Homo sapiens_hsa051100.48443228
160Viral myocarditis_Homo sapiens_hsa054160.48161977
161Glycerolipid metabolism_Homo sapiens_hsa005610.48152708
162Complement and coagulation cascades_Homo sapiens_hsa046100.46946276
163Melanogenesis_Homo sapiens_hsa049160.45089518

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