FLRT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of extracellular ligand from receptor (GO:0035581)4.41786936
2chondrocyte proliferation (GO:0035988)4.34695699
3axon extension involved in axon guidance (GO:0048846)4.16750550
4neuron projection extension involved in neuron projection guidance (GO:1902284)4.16750550
5axonal fasciculation (GO:0007413)4.09205678
6kidney mesenchyme development (GO:0072074)3.70687592
7collagen fibril organization (GO:0030199)3.60161133
8neuron recognition (GO:0008038)3.53844170
9lymphangiogenesis (GO:0001946)3.50473371
10insulin-like growth factor receptor signaling pathway (GO:0048009)3.46226260
11response to pheromone (GO:0019236)3.43104077
12regulation of sarcomere organization (GO:0060297)3.32394910
13hemidesmosome assembly (GO:0031581)3.30808474
14artery development (GO:0060840)3.23121523
15bone trabecula formation (GO:0060346)3.18700857
16chondrocyte development (GO:0002063)3.15059407
17vocalization behavior (GO:0071625)3.06971152
18dendritic spine morphogenesis (GO:0060997)3.05186919
19behavioral response to nicotine (GO:0035095)3.04365864
20layer formation in cerebral cortex (GO:0021819)3.04187650
21locomotory exploration behavior (GO:0035641)3.02296842
22metanephric mesenchyme development (GO:0072075)2.97459345
23synaptic vesicle docking involved in exocytosis (GO:0016081)2.95321489
24limb bud formation (GO:0060174)2.94112113
25hippo signaling (GO:0035329)2.93977253
26dermatan sulfate biosynthetic process (GO:0030208)2.92219859
27G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.90605968
28positive regulation of fibroblast migration (GO:0010763)2.90375433
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88957761
30negative regulation of chondrocyte differentiation (GO:0032331)2.85911210
31neuron cell-cell adhesion (GO:0007158)2.85778685
32regulation of axon guidance (GO:1902667)2.85179154
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85002472
34axon extension (GO:0048675)2.83109952
35membrane depolarization during action potential (GO:0086010)2.81251494
36establishment of planar polarity (GO:0001736)2.80683704
37establishment of tissue polarity (GO:0007164)2.80683704
38regulation of axon extension involved in axon guidance (GO:0048841)2.78995589
39negative regulation of systemic arterial blood pressure (GO:0003085)2.78837474
40extracellular fibril organization (GO:0043206)2.76896449
41cell proliferation involved in metanephros development (GO:0072203)2.76461334
42gamma-aminobutyric acid transport (GO:0015812)2.75208278
43glomerular basement membrane development (GO:0032836)2.75187432
44protein heterotrimerization (GO:0070208)2.74813411
45regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74387797
46negative regulation of axon guidance (GO:1902668)2.74147427
47body morphogenesis (GO:0010171)2.72478921
48limb development (GO:0060173)2.69390490
49appendage development (GO:0048736)2.69390490
50regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.69018851
51synaptic vesicle exocytosis (GO:0016079)2.67192743
52protein localization to synapse (GO:0035418)2.65607155
53exocrine pancreas development (GO:0031017)2.65456778
54exploration behavior (GO:0035640)2.65057592
55positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.64248684
56dendrite morphogenesis (GO:0048813)2.63087276
57acrosome reaction (GO:0007340)2.63087136
58central nervous system projection neuron axonogenesis (GO:0021952)2.62430723
59negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61955276
60regulation of female gonad development (GO:2000194)2.61515677
61negative regulation of axon extension involved in axon guidance (GO:0048843)2.61389991
62extracellular regulation of signal transduction (GO:1900115)2.61357641
63extracellular negative regulation of signal transduction (GO:1900116)2.61357641
64dermatan sulfate metabolic process (GO:0030205)2.60308452
65presynaptic membrane organization (GO:0097090)2.60252493
66cell proliferation involved in kidney development (GO:0072111)2.60095088
67regulation of long-term neuronal synaptic plasticity (GO:0048169)2.59350072
68protein polyglutamylation (GO:0018095)2.58506357
69negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57946745
70retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57803480
71ephrin receptor signaling pathway (GO:0048013)2.57093655
72negative regulation of catenin import into nucleus (GO:0035414)2.57020382
73neuronal action potential propagation (GO:0019227)2.56410550
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.54849354
75smooth muscle tissue development (GO:0048745)2.54809898
76glutamate secretion (GO:0014047)2.54635781
77lymph vessel development (GO:0001945)2.54369453
78regulation of glutamate receptor signaling pathway (GO:1900449)2.53828875
79plasma membrane repair (GO:0001778)2.53697389
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.53325464
81regulation of dendritic spine morphogenesis (GO:0061001)2.52536686
82planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49670012
83positive regulation of cardiac muscle hypertrophy (GO:0010613)2.49014260
84positive regulation of muscle hypertrophy (GO:0014742)2.49014260
85positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.48836452
86craniofacial suture morphogenesis (GO:0097094)2.48252656
87negative regulation of embryonic development (GO:0045992)2.47651254
88establishment of nucleus localization (GO:0040023)2.47614523
89central nervous system neuron axonogenesis (GO:0021955)2.47442435
90* negative chemotaxis (GO:0050919)2.46255571
91synaptic vesicle maturation (GO:0016188)2.45897527
92somite development (GO:0061053)2.45307869
93glutamate receptor signaling pathway (GO:0007215)2.45304923
94renal tubule morphogenesis (GO:0061333)2.43844135
95sperm motility (GO:0030317)2.43511829
96positive regulation of synapse maturation (GO:0090129)2.42299423
97endodermal cell differentiation (GO:0035987)2.41448931
98neuron projection extension (GO:1990138)2.41169899
99reflex (GO:0060004)2.41090486
100regulation of mesoderm development (GO:2000380)2.41073011
101regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40672155
102innervation (GO:0060384)2.40534028
103presynaptic membrane assembly (GO:0097105)2.39354212
104mesenchymal-epithelial cell signaling (GO:0060638)2.39166449
105positive regulation of male gonad development (GO:2000020)2.37286397
106positive regulation of cardiac muscle cell differentiation (GO:2000727)2.36665319
107regulation of hippo signaling (GO:0035330)2.36277046
108camera-type eye morphogenesis (GO:0048593)2.36125536
109postsynaptic membrane organization (GO:0001941)2.36072634
110prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.35850927
111startle response (GO:0001964)2.35415437
112dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.35050119
113membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.35043968
114collagen metabolic process (GO:0032963)2.34819750
115regulation of mesenchymal cell proliferation (GO:0010464)2.34705597
116collagen catabolic process (GO:0030574)2.33943199
117regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.32885641
118positive regulation of synapse assembly (GO:0051965)2.32159078
119positive regulation of mesenchymal cell proliferation (GO:0002053)2.32040728
120auditory behavior (GO:0031223)2.31362188
121embryonic cranial skeleton morphogenesis (GO:0048701)2.30380632
122mesenchymal cell proliferation (GO:0010463)2.29915264
123positive regulation of glycogen biosynthetic process (GO:0045725)2.29823250
124transmission of nerve impulse (GO:0019226)2.29621264
125calcium ion-dependent exocytosis (GO:0017156)2.29007196
126primary amino compound metabolic process (GO:1901160)2.28509157
127pyrimidine nucleobase catabolic process (GO:0006208)2.28029452
128negative regulation of keratinocyte proliferation (GO:0010839)2.27985409
129regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.27696484
130glomerular epithelial cell development (GO:0072310)2.27373189
131dendritic spine organization (GO:0097061)2.27107455
132retinal ganglion cell axon guidance (GO:0031290)2.26813422
133serotonin metabolic process (GO:0042428)2.26573629
134regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.26390059
135regulation of synapse assembly (GO:0051963)2.26231710
136neuromuscular junction development (GO:0007528)2.25150906
137negative regulation of protein localization to cell surface (GO:2000009)2.22828835
138cochlea development (GO:0090102)2.21645457
139atrial cardiac muscle cell action potential (GO:0086014)2.20734647
140kidney morphogenesis (GO:0060993)2.17974131
141nephron tubule morphogenesis (GO:0072078)2.17119735
142nephron epithelium morphogenesis (GO:0072088)2.17119735
143neuromuscular synaptic transmission (GO:0007274)2.17025129
144spinal cord motor neuron differentiation (GO:0021522)2.16472842
145detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.16352453
146neuronal action potential (GO:0019228)2.16286684
147interkinetic nuclear migration (GO:0022027)2.15960379
148regulation of non-canonical Wnt signaling pathway (GO:2000050)2.15512355
149cornea development in camera-type eye (GO:0061303)2.15443037
150detection of light stimulus involved in visual perception (GO:0050908)2.15132679
151detection of light stimulus involved in sensory perception (GO:0050962)2.15132679
152regulation of cardiac muscle cell differentiation (GO:2000725)2.14581282
153cranial nerve structural organization (GO:0021604)2.13898932
154cell proliferation in forebrain (GO:0021846)2.13152826
155homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.12845360
156ganglion development (GO:0061548)2.11260998
157detection of mechanical stimulus involved in sensory perception (GO:0050974)2.09318717
158cerebral cortex radially oriented cell migration (GO:0021799)2.08274386
159cAMP catabolic process (GO:0006198)2.08166634
160negative regulation of astrocyte differentiation (GO:0048712)2.06248048
161cardiac myofibril assembly (GO:0055003)2.05960821
162regulation of male gonad development (GO:2000018)2.05443018
163sulfation (GO:0051923)2.05021123
164establishment of protein localization to Golgi (GO:0072600)2.04095700
165neurotransmitter-gated ion channel clustering (GO:0072578)2.02698084
166cyclic nucleotide catabolic process (GO:0009214)2.02468423
167inner ear receptor stereocilium organization (GO:0060122)2.02447298
168regulation of pigment cell differentiation (GO:0050932)2.02113245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.64810948
2GBX2_23144817_ChIP-Seq_PC3_Human3.14286108
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99772428
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89510095
5* EED_16625203_ChIP-ChIP_MESCs_Mouse2.89093954
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79953181
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79953181
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75187471
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68546649
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66537930
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.60923978
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.60818775
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58766284
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46792575
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45248214
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31227204
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21363651
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.14795922
19* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.14675396
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11236592
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01937881
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98177478
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.89966449
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83052373
25TP53_18474530_ChIP-ChIP_U2OS_Human1.80892316
26VDR_22108803_ChIP-Seq_LS180_Human1.79319283
27* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78154894
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.75810108
29* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73363589
30TP53_16413492_ChIP-PET_HCT116_Human1.73221028
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72584700
32AR_21572438_ChIP-Seq_LNCaP_Human1.71979651
33* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71908233
34* EZH2_27294783_Chip-Seq_ESCs_Mouse1.70383730
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.69946063
36* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68217441
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66647696
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66495090
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65971321
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63331421
41* CBX2_27304074_Chip-Seq_ESCs_Mouse1.63164423
42* EP300_21415370_ChIP-Seq_HL-1_Mouse1.56639891
43TAF15_26573619_Chip-Seq_HEK293_Human1.56562534
44FUS_26573619_Chip-Seq_HEK293_Human1.56312813
45* TP53_20018659_ChIP-ChIP_R1E_Mouse1.53305161
46SMAD4_21799915_ChIP-Seq_A2780_Human1.52568858
47* P300_19829295_ChIP-Seq_ESCs_Human1.52227890
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50852400
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50852400
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49113189
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49113189
52DROSHA_22980978_ChIP-Seq_HELA_Human1.48379339
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48206918
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.47007112
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46417481
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46139212
57* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45640322
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44938870
59* ARNT_22903824_ChIP-Seq_MCF-7_Human1.42401493
60* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41462663
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40944573
62* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.39143805
63ZNF274_21170338_ChIP-Seq_K562_Hela1.37475869
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36347006
65AHR_22903824_ChIP-Seq_MCF-7_Human1.35641656
66* TCF4_23295773_ChIP-Seq_U87_Human1.34729298
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34523648
68* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32597827
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32420864
70* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31767068
71RXR_22108803_ChIP-Seq_LS180_Human1.31763944
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31649284
73* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31059768
74* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30620315
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.30056253
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29840881
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29815426
78CJUN_26792858_Chip-Seq_BT549_Human1.28252303
79* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26518668
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26114416
81IGF1R_20145208_ChIP-Seq_DFB_Human1.24705930
82ER_23166858_ChIP-Seq_MCF-7_Human1.24052046
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22345437
84CBP_20019798_ChIP-Seq_JUKART_Human1.22345437
85* AR_25329375_ChIP-Seq_VCAP_Human1.22216905
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22208384
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21403751
88* SOX2_21211035_ChIP-Seq_LN229_Gbm1.21333539
89BCAT_22108803_ChIP-Seq_LS180_Human1.20071267
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19722667
91* KDM2B_26808549_Chip-Seq_REH_Human1.16592385
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16225689
93AR_19668381_ChIP-Seq_PC3_Human1.15138566
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13675133
95* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13315162
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.12905902
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.12695367
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.12524249
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12105854
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10345167
101* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10127976
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09965496
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.09933654
104* RARB_27405468_Chip-Seq_BRAIN_Mouse1.09138445
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.08390855
106SMAD3_21741376_ChIP-Seq_ESCs_Human1.07477884
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06962621
108* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06709367
109JUN_21703547_ChIP-Seq_K562_Human1.06402930
110EWS_26573619_Chip-Seq_HEK293_Human1.06266209
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06103272
112TP63_17297297_ChIP-ChIP_HaCaT_Human1.05632676
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05441393
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05393302
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03806361
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03581340
117* PRDM14_20953172_ChIP-Seq_ESCs_Human1.03021194
118BRD4_25478319_ChIP-Seq_HGPS_Human1.02680237
119RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01918994
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.01456154
121* STAT3_23295773_ChIP-Seq_U87_Human1.01149025
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99933320
123* RUNX2_22187159_ChIP-Seq_PCA_Human0.98800198
124REST_21632747_ChIP-Seq_MESCs_Mouse0.95113848
125RNF2_27304074_Chip-Seq_NSC_Mouse0.94456715
126* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93918260
127* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93219838
128* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91429514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.33166462
2MP0005503_abnormal_tendon_morphology3.60378633
3MP0004859_abnormal_synaptic_plasticity3.18015281
4MP0003122_maternal_imprinting3.01016508
5MP0005275_abnormal_skin_tensile2.81384470
6MP0003385_abnormal_body_wall2.73525618
7MP0005623_abnormal_meninges_morphology2.64740642
8MP0003880_abnormal_central_pattern2.58098333
9MP0004272_abnormal_basement_membrane2.41984077
10MP0003279_aneurysm2.13473304
11MP0003705_abnormal_hypodermis_morpholog2.07153118
12MP0009384_cardiac_valve_regurgitation2.05669325
13MP0009250_abnormal_appendicular_skeleto2.05450044
14MP0003635_abnormal_synaptic_transmissio1.96261171
15MP0003942_abnormal_urinary_system1.95253636
16MP0005171_absent_coat_pigmentation1.87242898
17MP0000534_abnormal_ureter_morphology1.83874769
18MP0003123_paternal_imprinting1.70976873
19MP0002249_abnormal_larynx_morphology1.70821566
20MP0004885_abnormal_endolymph1.69719776
21MP0004270_analgesia1.68587746
22MP0005508_abnormal_skeleton_morphology1.59773734
23MP0001299_abnormal_eye_distance/1.59212529
24MP0001958_emphysema1.58497452
25MP0002735_abnormal_chemical_nociception1.58385239
26MP0000579_abnormal_nail_morphology1.55339027
27MP0005410_abnormal_fertilization1.55099021
28MP0002272_abnormal_nervous_system1.54072279
29MP0002102_abnormal_ear_morphology1.52674691
30MP0002063_abnormal_learning/memory/cond1.52326027
31MP0003755_abnormal_palate_morphology1.51708061
32MP0010030_abnormal_orbit_morphology1.50888936
33MP0002108_abnormal_muscle_morphology1.50852495
34MP0001501_abnormal_sleep_pattern1.50516893
35MP0000778_abnormal_nervous_system1.47969695
36MP0009780_abnormal_chondrocyte_physiolo1.46165002
37MP0002282_abnormal_trachea_morphology1.45748514
38MP0000049_abnormal_middle_ear1.45568009
39MP0004233_abnormal_muscle_weight1.44525451
40MP0005257_abnormal_intraocular_pressure1.42267307
41MP0003121_genomic_imprinting1.41608795
42MP0005551_abnormal_eye_electrophysiolog1.41378222
43MP0001968_abnormal_touch/_nociception1.40157091
44MP0002938_white_spotting1.38790646
45MP0003941_abnormal_skin_development1.37447675
46MP0009053_abnormal_anal_canal1.35956618
47MP0006054_spinal_hemorrhage1.33275454
48MP0006276_abnormal_autonomic_nervous1.31586876
49MP0003115_abnormal_respiratory_system1.30396457
50MP0001485_abnormal_pinna_reflex1.30103194
51MP0000537_abnormal_urethra_morphology1.28867179
52MP0009745_abnormal_behavioral_response1.25184805
53MP0002295_abnormal_pulmonary_circulatio1.23341402
54MP0010386_abnormal_urinary_bladder1.21677539
55MP0002736_abnormal_nociception_after1.21522660
56MP0002932_abnormal_joint_morphology1.21428812
57MP0002896_abnormal_bone_mineralization1.21210398
58MP0003787_abnormal_imprinting1.20789098
59MP0001879_abnormal_lymphatic_vessel1.19760021
60MP0000383_abnormal_hair_follicle1.19292757
61MP0003091_abnormal_cell_migration1.17427340
62MP0000428_abnormal_craniofacial_morphol1.17092502
63MP0002116_abnormal_craniofacial_bone1.16870806
64MP0000516_abnormal_urinary_system1.15424505
65MP0005367_renal/urinary_system_phenotyp1.15424505
66MP0002233_abnormal_nose_morphology1.15188996
67MP0000733_abnormal_muscle_development1.14363094
68MP0002184_abnormal_innervation1.12982598
69MP0005670_abnormal_white_adipose1.12027795
70MP0000026_abnormal_inner_ear1.11579372
71MP0000569_abnormal_digit_pigmentation1.10603717
72MP0003646_muscle_fatigue1.10212366
73MP0002064_seizures1.10059905
74MP0002557_abnormal_social/conspecific_i1.09962776
75MP0000163_abnormal_cartilage_morphology1.09899526
76MP0003935_abnormal_craniofacial_develop1.09634097
77MP0002067_abnormal_sensory_capabilities1.08989434
78MP0002572_abnormal_emotion/affect_behav1.07220985
79MP0000762_abnormal_tongue_morphology1.06931410
80MP0004142_abnormal_muscle_tone1.05841934
81MP0003937_abnormal_limbs/digits/tail_de1.04877277
82MP0006138_congestive_heart_failure1.04173493
83MP0003283_abnormal_digestive_organ1.04004851
84MP0005253_abnormal_eye_physiology1.03886231
85MP0004858_abnormal_nervous_system1.02848119
86MP0005248_abnormal_Harderian_gland1.02256537
87MP0004145_abnormal_muscle_electrophysio1.01631496
88MP0002115_abnormal_skeleton_extremities1.01022226
89MP0004484_altered_response_of1.00360460
90MP0002733_abnormal_thermal_nociception0.99708712
91MP0001970_abnormal_pain_threshold0.98617056
92MP0000432_abnormal_head_morphology0.98240489
93MP0004085_abnormal_heartbeat0.98097768
94MP0003878_abnormal_ear_physiology0.98091899
95MP0005377_hearing/vestibular/ear_phenot0.98091899
96MP0006292_abnormal_olfactory_placode0.96834267
97MP0002109_abnormal_limb_morphology0.95213634
98MP0000538_abnormal_urinary_bladder0.94778300
99MP0001177_atelectasis0.94413104
100MP0003938_abnormal_ear_development0.94357978
101MP0006072_abnormal_retinal_apoptosis0.94166058
102MP0000751_myopathy0.94081779
103MP0001486_abnormal_startle_reflex0.93040565
104MP0003890_abnormal_embryonic-extraembry0.92954366
105MP0005423_abnormal_somatic_nervous0.92616410
106MP0000427_abnormal_hair_cycle0.92217467
107MP0002734_abnormal_mechanical_nocicepti0.92105920
108MP0000631_abnormal_neuroendocrine_gland0.89907617
109MP0002177_abnormal_outer_ear0.89770205
110MP0009046_muscle_twitch0.88538096
111MP0000767_abnormal_smooth_muscle0.88233489
112MP0002113_abnormal_skeleton_development0.86807517
113MP0002882_abnormal_neuron_morphology0.85485147
114MP0005076_abnormal_cell_differentiation0.84599775
115MP0002752_abnormal_somatic_nervous0.84535165
116MP0004924_abnormal_behavior0.84425719
117MP0005386_behavior/neurological_phenoty0.84425719
118MP0001963_abnormal_hearing_physiology0.83682448
119MP0005620_abnormal_muscle_contractility0.83437416
120MP0003011_delayed_dark_adaptation0.82952710
121MP0004133_heterotaxia0.82756822
122MP0004215_abnormal_myocardial_fiber0.82545524
123MP0001340_abnormal_eyelid_morphology0.81263485
124MP0002114_abnormal_axial_skeleton0.81026460
125MP0008775_abnormal_heart_ventricle0.80924053
126MP0005195_abnormal_posterior_eye0.80834834
127MP0003828_pulmonary_edema0.80807888
128MP0005595_abnormal_vascular_smooth0.78272554
129MP0002837_dystrophic_cardiac_calcinosis0.77708867
130MP0002081_perinatal_lethality0.77202523
131MP0001440_abnormal_grooming_behavior0.76613886
132MP0010368_abnormal_lymphatic_system0.76102295
133MP0002234_abnormal_pharynx_morphology0.76044557
134MP0004134_abnormal_chest_morphology0.75903010
135MP0005187_abnormal_penis_morphology0.75185519
136MP0000955_abnormal_spinal_cord0.75034445
137MP0004811_abnormal_neuron_physiology0.74938054
138MP0002133_abnormal_respiratory_system0.74684163
139MP0005388_respiratory_system_phenotype0.74684163
140MP0003119_abnormal_digestive_system0.74393947

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.18427506
2Premature rupture of membranes (HP:0001788)4.32505505
3Shallow orbits (HP:0000586)4.23006695
4Genetic anticipation (HP:0003743)3.48827478
5Asymmetry of the thorax (HP:0001555)3.37452033
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.36179725
7Short 4th metacarpal (HP:0010044)3.36179725
8Abnormality of the ischium (HP:0003174)3.33656405
9Progressive cerebellar ataxia (HP:0002073)3.24085474
10Hypoplastic ischia (HP:0003175)3.20423180
11Buphthalmos (HP:0000557)3.18962890
12Overgrowth (HP:0001548)3.13206247
13Aortic dissection (HP:0002647)3.02485828
14Soft skin (HP:0000977)2.94914153
15Follicular hyperkeratosis (HP:0007502)2.91792908
16Hepatoblastoma (HP:0002884)2.86100168
17Focal motor seizures (HP:0011153)2.84381823
18Bladder diverticulum (HP:0000015)2.83553395
19Broad metatarsal (HP:0001783)2.82569324
20Keratoconus (HP:0000563)2.79608884
21Increased corneal curvature (HP:0100692)2.79608884
22Mitral valve prolapse (HP:0001634)2.70801908
23Aplasia/Hypoplasia of the tibia (HP:0005772)2.67186781
24Dilatation of the ascending aorta (HP:0005111)2.65764581
25Cerebral aneurysm (HP:0004944)2.62680973
26Atonic seizures (HP:0010819)2.61332826
27Abnormality of the 4th metacarpal (HP:0010012)2.61237773
28Pancreatic cysts (HP:0001737)2.60451089
29Nephronophthisis (HP:0000090)2.60184034
30Ankle contracture (HP:0006466)2.58090482
31Pancreatic fibrosis (HP:0100732)2.57234838
32Atrophic scars (HP:0001075)2.56492915
33Abnormality of dentin (HP:0010299)2.52972981
34Vascular tortuosity (HP:0004948)2.51169589
35Aortic aneurysm (HP:0004942)2.50062554
36Neonatal short-limb short stature (HP:0008921)2.48528877
37True hermaphroditism (HP:0010459)2.45954841
38Microglossia (HP:0000171)2.45782745
39Genu recurvatum (HP:0002816)2.41809852
40Abnormality of the renal medulla (HP:0100957)2.41226882
41Chorioretinal atrophy (HP:0000533)2.40348383
42Spinal cord lesions (HP:0100561)2.38799743
43Syringomyelia (HP:0003396)2.38799743
44Arterial tortuosity (HP:0005116)2.37547572
45Focal seizures (HP:0007359)2.37214648
46Preaxial foot polydactyly (HP:0001841)2.33472563
47Ankyloglossia (HP:0010296)2.27224100
48Abnormality of the pubic bones (HP:0003172)2.26000160
49Hyperextensible skin (HP:0000974)2.25128480
50Epileptic encephalopathy (HP:0200134)2.25077156
51Hyperventilation (HP:0002883)2.22817310
52Broad ribs (HP:0000885)2.21788687
53Coronal craniosynostosis (HP:0004440)2.21375643
54Febrile seizures (HP:0002373)2.20883714
55Wrist flexion contracture (HP:0001239)2.20714919
56Gaze-evoked nystagmus (HP:0000640)2.20653462
57Congenital stationary night blindness (HP:0007642)2.20531813
58Absent speech (HP:0001344)2.18120391
59Chronic hepatic failure (HP:0100626)2.18079900
60Bulbous nose (HP:0000414)2.17972745
61Molar tooth sign on MRI (HP:0002419)2.17787137
62Abnormality of midbrain morphology (HP:0002418)2.17787137
63Wormian bones (HP:0002645)2.14987219
64Tubular atrophy (HP:0000092)2.09519773
65Fragile skin (HP:0001030)2.09280764
66Wide anterior fontanel (HP:0000260)2.08103033
67Type II lissencephaly (HP:0007260)2.06365252
68Anterior segment dysgenesis (HP:0007700)2.02999020
69Vitreoretinal degeneration (HP:0000655)2.01396956
70Cerebellar dysplasia (HP:0007033)2.00698650
71Cervical subluxation (HP:0003308)2.00475913
72Hypoplasia of the iris (HP:0007676)2.00014165
73Infantile muscular hypotonia (HP:0008947)1.99572574
74Morphological abnormality of the middle ear (HP:0008609)1.99202124
75Hypoventilation (HP:0002791)1.98617567
76Broad toe (HP:0001837)1.97259342
77Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96884649
78Drooling (HP:0002307)1.96343832
79Congenital glaucoma (HP:0001087)1.96274647
80Blue sclerae (HP:0000592)1.96159090
81Abnormality of oral frenula (HP:0000190)1.95769462
82Amblyopia (HP:0000646)1.95705569
83Cutaneous finger syndactyly (HP:0010554)1.95497885
84Oligodontia (HP:0000677)1.95099284
85Broad long bones (HP:0005622)1.94422135
86Short tibia (HP:0005736)1.93990730
87Fragile nails (HP:0001808)1.92221021
88Fibular hypoplasia (HP:0003038)1.91761861
89Protruding tongue (HP:0010808)1.91321025
90Increased number of teeth (HP:0011069)1.89687300
91Broad-based gait (HP:0002136)1.88475570
92Absent frontal sinuses (HP:0002688)1.87962798
93Mesomelia (HP:0003027)1.87589251
94Cystic liver disease (HP:0006706)1.86292894
95Aplasia involving bones of the extremities (HP:0009825)1.85912506
96Aplasia involving bones of the upper limbs (HP:0009823)1.85912506
97Aplasia of the phalanges of the hand (HP:0009802)1.85912506
98Sclerocornea (HP:0000647)1.85859128
99Narrow nasal bridge (HP:0000446)1.85132650
100Aplasia/Hypoplasia of the fibula (HP:0006492)1.85121037
101Deviation of the hallux (HP:0010051)1.85056458
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.84266797
103Biconcave vertebral bodies (HP:0004586)1.82257388
104Peritonitis (HP:0002586)1.81930703
105Milia (HP:0001056)1.81421144
106Nuclear cataract (HP:0100018)1.80421777
107Cupped ear (HP:0000378)1.80178505
108Inability to walk (HP:0002540)1.80072847
109Hemiparesis (HP:0001269)1.79563552
110Absence seizures (HP:0002121)1.79140140
111Type 1 muscle fiber predominance (HP:0003803)1.78956278
112Widely spaced teeth (HP:0000687)1.78359804
113Lymphangioma (HP:0100764)1.77385614
114Midline defect of the nose (HP:0004122)1.76590867
115Genital tract atresia (HP:0001827)1.76444821
116Hypoplastic labia majora (HP:0000059)1.76026592
117Joint laxity (HP:0001388)1.75830831
118Venous insufficiency (HP:0005293)1.75054455
119Hip contracture (HP:0003273)1.74450831
120Hallux valgus (HP:0001822)1.74222331
121Anophthalmia (HP:0000528)1.73746833
122Mitral regurgitation (HP:0001653)1.73315670
123Renal duplication (HP:0000075)1.72625380
124Abnormality of binocular vision (HP:0011514)1.71912553
125Diplopia (HP:0000651)1.71912553
126Slender build (HP:0001533)1.71907851
127Attenuation of retinal blood vessels (HP:0007843)1.71748739
128Broad thumb (HP:0011304)1.71671469
129Short hallux (HP:0010109)1.71484681
130Narrow palate (HP:0000189)1.71297648
131Abnormality of the labia majora (HP:0012881)1.70900169
132Broad phalanx (HP:0006009)1.70650777
133Increased variability in muscle fiber diameter (HP:0003557)1.70583037
134Spinal rigidity (HP:0003306)1.70143250
135Exotropia (HP:0000577)1.69913089
136Abnormality of the renal cortex (HP:0011035)1.67689171
137Abnormality of the parietal bone (HP:0002696)1.67532236
138Osteopenia (HP:0000938)1.65756617
139Excessive salivation (HP:0003781)1.65585114
140Abnormality of the phalanges of the hallux (HP:0010057)1.65498860
141Stenosis of the external auditory canal (HP:0000402)1.65341376
142Bony spicule pigmentary retinopathy (HP:0007737)1.65238034
143Bowel diverticulosis (HP:0005222)1.65180694
144Conical tooth (HP:0000698)1.64968140
145Abnormality of the nasal septum (HP:0000419)1.64800653
146Limited hip movement (HP:0008800)1.64509586
147Hydroureter (HP:0000072)1.64212081
148Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64127622
149Flat face (HP:0012368)1.63711364
150Hypoplasia of the maxilla (HP:0000327)1.63481316
151Renal hypoplasia (HP:0000089)1.63122739
152Heterochromia iridis (HP:0001100)1.62419194
153Occipital encephalocele (HP:0002085)1.62002902
154Cutaneous syndactyly (HP:0012725)1.61889225
155Congenital, generalized hypertrichosis (HP:0004540)1.61847851
156Vaginal atresia (HP:0000148)1.61730232
157Broad finger (HP:0001500)1.61568944
158Camptodactyly of toe (HP:0001836)1.61313084
159Synostosis of carpal bones (HP:0005048)1.61067620
160Broad hallux (HP:0010055)1.60384071
161Lower limb amyotrophy (HP:0007210)1.59506444
162Venous abnormality (HP:0002624)1.59281581
163Action tremor (HP:0002345)1.59185563
164Long nose (HP:0003189)1.58414202
165Renal dysplasia (HP:0000110)1.57864652
166Round ear (HP:0100830)1.57754815
167Congenital sensorineural hearing impairment (HP:0008527)1.57552204
168Tubulointerstitial fibrosis (HP:0005576)1.56984295
169Optic nerve hypoplasia (HP:0000609)1.56689830
170Elbow flexion contracture (HP:0002987)1.56522227
171Bell-shaped thorax (HP:0001591)1.56416629
172Small hand (HP:0200055)1.55312758
173Tracheomalacia (HP:0002779)1.55113917
174Fibular aplasia (HP:0002990)1.54673140
175Hypoplastic iliac wings (HP:0002866)1.54158853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.05351057
2DDR23.16949008
3CASK3.09112259
4NTRK32.88508182
5PLK22.82011701
6EPHB22.74390646
7TIE12.62645525
8KSR12.44139798
9MAP3K42.40127594
10INSRR2.33096185
11BMPR1B2.31204524
12ADRBK22.29875534
13CAMK1G2.22695709
14NTRK12.22114320
15MARK12.18418506
16LATS22.07362982
17PNCK1.99897699
18PDGFRA1.97794941
19MINK11.91321242
20MAP2K71.87180176
21GRK11.85189243
22PTK2B1.78040589
23WNK31.77945302
24TTN1.73150218
25RIPK41.71157734
26EPHA31.70334922
27PAK61.68135509
28ACVR1B1.67831258
29STK38L1.57361455
30LATS11.56892893
31DMPK1.56790329
32MAP3K91.52803661
33DAPK21.50956400
34TGFBR11.50201584
35NTRK21.49294067
36TNIK1.47855192
37PAK31.39745665
38ERBB31.36471743
39PINK11.30541434
40FER1.26205728
41TRIB31.24991232
42AKT31.22705647
43MAPK151.22157593
44STK381.19756322
45MAP2K41.19086483
46STK391.16518428
47CAMK1D1.13965735
48OBSCN1.12113891
49OXSR11.11961255
50SGK2231.10309655
51SGK4941.10309655
52CAMKK11.07907908
53FRK1.06996823
54PRKD31.05317600
55SIK31.04712495
56PAK21.03718518
57BCR1.03477486
58ROCK10.94174611
59SIK20.93811383
60KSR20.93424213
61PIK3CA0.90973065
62MAPK130.90626294
63CDK180.90048257
64CDK50.89951938
65CDK140.89376054
66FGFR20.88837101
67PRKCG0.86429599
68PRKCE0.86023329
69WNK40.85712357
70ROCK20.85514424
71CAMK2A0.82468265
72FGFR10.82127750
73PTK20.81902798
74RIPK10.80706736
75PHKG10.80539786
76PHKG20.80539786
77CDK150.79748024
78MKNK20.79443089
79PLK40.78148405
80MOS0.76005344
81MAP3K120.75868599
82PIK3CG0.75267369
83WNK10.74934919
84CAMKK20.71109835
85ADRBK10.70728000
86NUAK10.70697445
87GRK50.70043222
88MAP4K20.69951327
89PRKCH0.69548664
90DAPK10.68704590
91PKN10.67773945
92MAPK70.67743680
93TGFBR20.66801536
94MAP2K10.66025841
95CDK11A0.65374439
96SIK10.64809272
97CDK30.63811016
98PLK30.62071381
99PDGFRB0.61874956
100RPS6KA20.61353129
101FGR0.59134547
102RPS6KA60.58653728
103LMTK20.58071371
104NEK90.56726849
105SGK10.56562006
106CAMK2B0.55380379
107SCYL20.53891997
108RET0.53380695
109MAPKAPK50.52586185
110BMX0.52127182
111SRC0.51582444
112CAMK40.51415175
113ERBB20.51061694
114PKN20.49454019
115FYN0.49312901
116MAP3K20.48982226
117CSNK1G20.48699711
118PRKG10.48514831
119DYRK20.48081464
120TYRO30.46212952
121ILK0.45386389
122TAF10.44374443
123CAMK10.43644868
124MAP3K70.43581543
125SGK20.43031597
126STK110.42431938
127PRKACA0.42386174
128DAPK30.42317699
129INSR0.41907126
130CSNK1A10.40533013
131BMPR20.39032376
132CSNK1G10.38774792
133PRKAA10.37722373
134MARK20.36816006
135CSNK1A1L0.36799630
136SGK30.36655249
137MET0.35686494
138RAF10.35084578
139PRKCZ0.34442893
140CDC42BPA0.33939395
141STK30.33808405
142PRPF4B0.33264704
143MAPK100.32652763
144CCNB10.31691628
145DYRK1A0.31226612

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.30191067
2Phototransduction_Homo sapiens_hsa047441.94250682
3Long-term potentiation_Homo sapiens_hsa047201.92804126
4Circadian entrainment_Homo sapiens_hsa047131.84939738
5Axon guidance_Homo sapiens_hsa043601.82346863
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74954187
7ECM-receptor interaction_Homo sapiens_hsa045121.74329376
8Amphetamine addiction_Homo sapiens_hsa050311.69443300
9Glutamatergic synapse_Homo sapiens_hsa047241.66232765
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.65629956
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65112411
12GABAergic synapse_Homo sapiens_hsa047271.64876590
13Salivary secretion_Homo sapiens_hsa049701.63807344
14Glioma_Homo sapiens_hsa052141.63420415
15Focal adhesion_Homo sapiens_hsa045101.57238612
16Dilated cardiomyopathy_Homo sapiens_hsa054141.55553633
17Synaptic vesicle cycle_Homo sapiens_hsa047211.54812615
18Long-term depression_Homo sapiens_hsa047301.53246808
19Dopaminergic synapse_Homo sapiens_hsa047281.53073016
20Morphine addiction_Homo sapiens_hsa050321.50760658
21Melanogenesis_Homo sapiens_hsa049161.48689817
22Renin secretion_Homo sapiens_hsa049241.48154800
23Gap junction_Homo sapiens_hsa045401.44459495
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42798476
25Oxytocin signaling pathway_Homo sapiens_hsa049211.42083519
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41956056
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41495469
28Hedgehog signaling pathway_Homo sapiens_hsa043401.41315938
29Proteoglycans in cancer_Homo sapiens_hsa052051.41308210
30Adherens junction_Homo sapiens_hsa045201.38465618
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38307359
32Hippo signaling pathway_Homo sapiens_hsa043901.36744771
33Basal cell carcinoma_Homo sapiens_hsa052171.36675051
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35384259
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34482963
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32798923
37Olfactory transduction_Homo sapiens_hsa047401.32103735
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31739626
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30395424
40GnRH signaling pathway_Homo sapiens_hsa049121.30334225
41Gastric acid secretion_Homo sapiens_hsa049711.29561558
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28711740
43Cholinergic synapse_Homo sapiens_hsa047251.28541743
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27737258
45Linoleic acid metabolism_Homo sapiens_hsa005911.25656371
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22181785
47Estrogen signaling pathway_Homo sapiens_hsa049151.21265966
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20757979
49Insulin secretion_Homo sapiens_hsa049111.19115882
50Calcium signaling pathway_Homo sapiens_hsa040201.18791890
51Wnt signaling pathway_Homo sapiens_hsa043101.17949662
52Serotonergic synapse_Homo sapiens_hsa047261.17295270
53Butanoate metabolism_Homo sapiens_hsa006501.16209582
54cAMP signaling pathway_Homo sapiens_hsa040241.15658406
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.14026364
56Amoebiasis_Homo sapiens_hsa051461.12366167
57Cocaine addiction_Homo sapiens_hsa050301.11995225
58ErbB signaling pathway_Homo sapiens_hsa040121.11878639
59TGF-beta signaling pathway_Homo sapiens_hsa043501.11613496
60Protein digestion and absorption_Homo sapiens_hsa049741.09514065
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09024761
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08244285
63Nitrogen metabolism_Homo sapiens_hsa009101.07001838
64Rap1 signaling pathway_Homo sapiens_hsa040151.03987680
65Melanoma_Homo sapiens_hsa052181.03659066
66Ether lipid metabolism_Homo sapiens_hsa005651.03557529
67MicroRNAs in cancer_Homo sapiens_hsa052061.02184142
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.98940250
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97469975
70Renal cell carcinoma_Homo sapiens_hsa052110.93906692
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93438840
72Taste transduction_Homo sapiens_hsa047420.91970076
73Selenocompound metabolism_Homo sapiens_hsa004500.91696765
74Fatty acid biosynthesis_Homo sapiens_hsa000610.89001101
75Dorso-ventral axis formation_Homo sapiens_hsa043200.88742301
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88559334
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87652693
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87602226
79Tight junction_Homo sapiens_hsa045300.87123278
80ABC transporters_Homo sapiens_hsa020100.86421644
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85822454
82Colorectal cancer_Homo sapiens_hsa052100.85651788
83Vibrio cholerae infection_Homo sapiens_hsa051100.84963945
84Bladder cancer_Homo sapiens_hsa052190.82550455
85Ras signaling pathway_Homo sapiens_hsa040140.81809514
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.81260483
87Endometrial cancer_Homo sapiens_hsa052130.81208545
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.80139058
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79641268
90Steroid biosynthesis_Homo sapiens_hsa001000.79062850
91Oocyte meiosis_Homo sapiens_hsa041140.77857262
92mTOR signaling pathway_Homo sapiens_hsa041500.77760534
93Glycerolipid metabolism_Homo sapiens_hsa005610.76876276
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.76653733
95Prostate cancer_Homo sapiens_hsa052150.76487366
96Tryptophan metabolism_Homo sapiens_hsa003800.75412816
97VEGF signaling pathway_Homo sapiens_hsa043700.74894768
98Thyroid hormone synthesis_Homo sapiens_hsa049180.74435903
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74046816
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73171040
101MAPK signaling pathway_Homo sapiens_hsa040100.72858982
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.72404523
103Choline metabolism in cancer_Homo sapiens_hsa052310.72121371
104Collecting duct acid secretion_Homo sapiens_hsa049660.69797300
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69511150
106Type II diabetes mellitus_Homo sapiens_hsa049300.69352524
107Small cell lung cancer_Homo sapiens_hsa052220.69057325
108Pancreatic secretion_Homo sapiens_hsa049720.68763516
109Pathways in cancer_Homo sapiens_hsa052000.68673019
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68633543
111Circadian rhythm_Homo sapiens_hsa047100.67863760
112Ovarian steroidogenesis_Homo sapiens_hsa049130.67613152
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66302996
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66094960
115Chronic myeloid leukemia_Homo sapiens_hsa052200.65822746
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65152666
117Pancreatic cancer_Homo sapiens_hsa052120.63837317
118Cardiac muscle contraction_Homo sapiens_hsa042600.62968125
119Platelet activation_Homo sapiens_hsa046110.62755012
120Fat digestion and absorption_Homo sapiens_hsa049750.62022258
121Viral myocarditis_Homo sapiens_hsa054160.60709474
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.60596343
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60291620
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57963491
125Bile secretion_Homo sapiens_hsa049760.57856927
126Chemical carcinogenesis_Homo sapiens_hsa052040.51956809
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51927976
128Caffeine metabolism_Homo sapiens_hsa002320.48908402
129Retinol metabolism_Homo sapiens_hsa008300.46700274
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46531546
131Vitamin digestion and absorption_Homo sapiens_hsa049770.45812617

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