FLRT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)5.54301378
2presynaptic membrane assembly (GO:0097105)5.26810542
3somite development (GO:0061053)4.43074312
4embryonic foregut morphogenesis (GO:0048617)4.21772259
5hemidesmosome assembly (GO:0031581)4.00865322
6neuronal stem cell maintenance (GO:0097150)3.73320538
7vocalization behavior (GO:0071625)3.73180661
8regulation of transforming growth factor beta2 production (GO:0032909)3.65928507
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55866707
10lateral sprouting from an epithelium (GO:0060601)3.55025221
11* negative chemotaxis (GO:0050919)3.53521388
12neuron cell-cell adhesion (GO:0007158)3.53364864
13otic vesicle formation (GO:0030916)3.44175768
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43554832
15postsynaptic membrane organization (GO:0001941)3.40321049
16negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.37334868
17negative regulation of amino acid transport (GO:0051956)3.36998182
18protein localization to synapse (GO:0035418)3.31984810
19retinal ganglion cell axon guidance (GO:0031290)3.30116555
20neuron fate determination (GO:0048664)3.28119778
21neuron projection extension involved in neuron projection guidance (GO:1902284)3.21600993
22axon extension involved in axon guidance (GO:0048846)3.21600993
23membrane assembly (GO:0071709)3.19832072
24neurotransmitter-gated ion channel clustering (GO:0072578)3.18286869
25positive regulation of synapse assembly (GO:0051965)3.08843837
26mesenchymal cell proliferation (GO:0010463)3.07535013
27embryonic digestive tract morphogenesis (GO:0048557)3.07419945
28nephron epithelium morphogenesis (GO:0072088)3.06313646
29nephron tubule morphogenesis (GO:0072078)3.06313646
30artery development (GO:0060840)3.06122970
31hindbrain development (GO:0030902)3.05250851
32synaptic vesicle exocytosis (GO:0016079)3.04973196
33positive regulation of chemokine biosynthetic process (GO:0045080)3.04135511
34positive regulation of synapse maturation (GO:0090129)3.01485433
35thalamus development (GO:0021794)3.00285866
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00009493
37pyrimidine nucleobase catabolic process (GO:0006208)2.98317521
38regulation of fever generation (GO:0031620)2.97640881
39regulation of glutamate receptor signaling pathway (GO:1900449)2.96815233
40plasma membrane repair (GO:0001778)2.92300336
41regulation of mesoderm development (GO:2000380)2.92051962
42renal system development (GO:0072001)2.92003470
43regulation of mesenchymal cell apoptotic process (GO:2001053)2.91866619
44cerebral cortex radially oriented cell migration (GO:0021799)2.91522199
45dorsal/ventral axis specification (GO:0009950)2.91040037
46neuron recognition (GO:0008038)2.90663426
47branching involved in salivary gland morphogenesis (GO:0060445)2.89418134
48regulation of glutamate secretion (GO:0014048)2.89409837
49ionotropic glutamate receptor signaling pathway (GO:0035235)2.89190806
50regulation of short-term neuronal synaptic plasticity (GO:0048172)2.89058812
51phagosome maturation (GO:0090382)2.88916174
52dopaminergic neuron differentiation (GO:0071542)2.86799800
53bundle of His cell to Purkinje myocyte communication (GO:0086069)2.86764161
54negative regulation of protein localization to cell surface (GO:2000009)2.85772309
55notochord development (GO:0030903)2.85616256
56positive regulation of heat generation (GO:0031652)2.85515960
57negative regulation of keratinocyte proliferation (GO:0010839)2.84999062
58neural crest cell development (GO:0014032)2.83054639
59regulation of timing of cell differentiation (GO:0048505)2.82625156
60regulation of development, heterochronic (GO:0040034)2.81570192
61midbrain development (GO:0030901)2.81037952
62G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.80702927
63axonal fasciculation (GO:0007413)2.80036593
64cell proliferation involved in kidney development (GO:0072111)2.75440157
65regulation of non-canonical Wnt signaling pathway (GO:2000050)2.74215000
66renal tubule morphogenesis (GO:0061333)2.74207415
67glomerulus development (GO:0032835)2.73883182
68positive regulation of cardiac muscle cell differentiation (GO:2000727)2.73715359
69regulation of sarcomere organization (GO:0060297)2.72137832
70establishment of planar polarity (GO:0001736)2.72055440
71establishment of tissue polarity (GO:0007164)2.72055440
72lung-associated mesenchyme development (GO:0060484)2.71717068
73positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.71580676
74regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.71580676
75negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70763219
76eosinophil chemotaxis (GO:0048245)2.70694300
77regulation of synapse maturation (GO:0090128)2.69235644
78superoxide anion generation (GO:0042554)2.68307634
79positive regulation of cellular amide metabolic process (GO:0034250)2.68224930
80regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.67026458
81primitive streak formation (GO:0090009)2.66920445
82epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66634303
83intraciliary transport (GO:0042073)2.66198838
84transferrin transport (GO:0033572)2.65596937
85male genitalia development (GO:0030539)2.63992429
86radial glial cell differentiation (GO:0060019)2.63411072
87regulation of synapse assembly (GO:0051963)2.61988206
88positive regulation of gastrulation (GO:2000543)2.61970241
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.61414631
90cell proliferation involved in metanephros development (GO:0072203)2.60866218
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60666526
92positive regulation of monocyte chemotaxis (GO:0090026)2.58926176
93negative regulation of axon extension involved in axon guidance (GO:0048843)2.58868729
94negative regulation of oligodendrocyte differentiation (GO:0048715)2.58301909
95forebrain neuron differentiation (GO:0021879)2.57796169
96glutamate receptor signaling pathway (GO:0007215)2.57462724
97ectoderm development (GO:0007398)2.57290848
98regulation of dendritic cell antigen processing and presentation (GO:0002604)2.54890042
99pericardium development (GO:0060039)2.54854147
100positive regulation of macrophage cytokine production (GO:0060907)2.54290072
101negative regulation of epidermis development (GO:0045683)2.53928557
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53682531
103limb bud formation (GO:0060174)2.52773491
104positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.52240749
105cerebellar granule cell differentiation (GO:0021707)2.52084899
106epithelial cilium movement (GO:0003351)2.51482214
107facial nerve structural organization (GO:0021612)2.51131811
108embryonic pattern specification (GO:0009880)2.50368551
109somite rostral/caudal axis specification (GO:0032525)2.50211557
110negative regulation of axon guidance (GO:1902668)2.50052979
111gastrulation with mouth forming second (GO:0001702)2.49994258
112regulation of T-helper 2 cell differentiation (GO:0045628)2.49854701
113cardiac right ventricle morphogenesis (GO:0003215)2.49828842
114paraxial mesoderm development (GO:0048339)2.49459020
115regulation of keratinocyte proliferation (GO:0010837)2.49374311
116positive regulation of embryonic development (GO:0040019)2.48939923
117negative regulation of mast cell activation (GO:0033004)2.48833984
118regulation of axon extension involved in axon guidance (GO:0048841)2.48707624
119regulation of mononuclear cell migration (GO:0071675)2.47483039
120positive regulation of type 2 immune response (GO:0002830)2.47383008
121calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.47243550
122dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46916571
123neuron-neuron synaptic transmission (GO:0007270)2.45981600
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.45612547
125regulation of axon guidance (GO:1902667)2.44198740
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.43751124
127ferric iron transport (GO:0015682)2.43030166
128trivalent inorganic cation transport (GO:0072512)2.43030166
129regulation of cardioblast differentiation (GO:0051890)2.42821912
130positive regulation of actin filament depolymerization (GO:0030836)2.42154888
131synaptic vesicle docking involved in exocytosis (GO:0016081)2.41408474
132glial cell proliferation (GO:0014009)2.41307564
133locomotory exploration behavior (GO:0035641)2.40333468
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40121133
135smoothened signaling pathway (GO:0007224)2.39325801
136regulation of amino acid transport (GO:0051955)2.39115178
137energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.38396912
138ATP hydrolysis coupled proton transport (GO:0015991)2.38396912
139cell surface receptor signaling pathway involved in heart development (GO:0061311)2.37635145
140synaptic transmission, glutamatergic (GO:0035249)2.37390475
141startle response (GO:0001964)2.37307121
142ventricular cardiac muscle cell action potential (GO:0086005)2.37089520
143genitalia morphogenesis (GO:0035112)2.37001478
144cholesterol biosynthetic process (GO:0006695)2.36478396
145response to histamine (GO:0034776)2.36114081
146wound healing, spreading of epidermal cells (GO:0035313)2.36005443
147regulation of synaptic vesicle exocytosis (GO:2000300)2.35737410
148pancreas development (GO:0031016)2.35619194
149neural tube formation (GO:0001841)2.35426401
150heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.34909397
151lung epithelium development (GO:0060428)2.34355978
152sympathetic nervous system development (GO:0048485)2.33998569
153negative regulation of interleukin-17 production (GO:0032700)2.33560127
154regulation of synaptic transmission, glutamatergic (GO:0051966)2.32786544
155positive regulation of interleukin-6 production (GO:0032755)2.32360186
156cellular response to cholesterol (GO:0071397)2.31913048
157endocardial cushion morphogenesis (GO:0003203)2.31736906
158negative regulation of dendrite morphogenesis (GO:0050774)2.31587228
159eosinophil migration (GO:0072677)2.30702544
160reproductive system development (GO:0061458)2.30628354
161glutamate secretion (GO:0014047)2.30623305
162neutrophil activation involved in immune response (GO:0002283)2.30114228
163DNA integration (GO:0015074)2.30084539
164negative regulation of exocytosis (GO:0045920)2.30035011
165hindlimb morphogenesis (GO:0035137)2.29973931
166embryonic axis specification (GO:0000578)2.29694657
167mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.29603444
168regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.29265906
169organ formation (GO:0048645)2.27787022
170regulation of action potential (GO:0098900)2.26901944
171epithelial tube branching involved in lung morphogenesis (GO:0060441)2.26535664
172mesenchyme morphogenesis (GO:0072132)2.26377262
173negative regulation of axon extension (GO:0030517)2.26185980
174long-term synaptic potentiation (GO:0060291)2.24947975
175histamine secretion (GO:0001821)2.23228133
176auditory behavior (GO:0031223)2.21101851
177exploration behavior (GO:0035640)2.20184043
178positive regulation of calcium ion import (GO:0090280)2.19622175
179cranial nerve structural organization (GO:0021604)2.19528432
180positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.18184831
181detection of other organism (GO:0098543)2.16364237
182regulation of chemokine biosynthetic process (GO:0045073)2.15883576
183regulation of T-helper 1 cell differentiation (GO:0045625)2.15637090
184regulation of synapse organization (GO:0050807)2.15464014
185positive regulation by organism of defense response of other organism involved in symbiotic interact2.11765433
186modulation by symbiont of host immune response (GO:0052553)2.11765433
187modulation by symbiont of host defense response (GO:0052031)2.11765433
188modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.11765433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.64494116
2EZH2_22144423_ChIP-Seq_EOC_Human3.54145563
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.88203054
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69105727
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67112086
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.66918543
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65589659
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60627687
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54433416
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.54049400
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53204319
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.47712093
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42829526
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32938260
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32938260
16ZNF274_21170338_ChIP-Seq_K562_Hela2.32129128
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31133664
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31042050
19TAF15_26573619_Chip-Seq_HEK293_Human2.30575781
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28579326
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.07670098
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.06592837
23IGF1R_20145208_ChIP-Seq_DFB_Human2.06104662
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05288410
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.01675379
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.99070134
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.95638509
28P300_19829295_ChIP-Seq_ESCs_Human1.93409499
29* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93219351
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92824591
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86926083
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82999570
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81785475
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81558304
35TP53_18474530_ChIP-ChIP_U2OS_Human1.78446806
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75675635
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74588784
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73925610
39SMAD4_21799915_ChIP-Seq_A2780_Human1.72278457
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.69807164
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68375138
42AR_21572438_ChIP-Seq_LNCaP_Human1.67142928
43RNF2_27304074_Chip-Seq_NSC_Mouse1.66898814
44FUS_26573619_Chip-Seq_HEK293_Human1.62372898
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59756039
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56585518
47* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56309713
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.54543959
49* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54199669
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50692313
51* PIAS1_25552417_ChIP-Seq_VCAP_Human1.49222200
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48178712
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46039592
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45987469
55VDR_22108803_ChIP-Seq_LS180_Human1.45941801
56* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43115018
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.41198642
58AHR_22903824_ChIP-Seq_MCF-7_Human1.39609493
59* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38421549
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36227459
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.34744405
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34326945
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34097984
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34097984
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34061113
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33555705
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32476790
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31501253
69AR_25329375_ChIP-Seq_VCAP_Human1.30335361
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29663779
71SMAD3_21741376_ChIP-Seq_HESCs_Human1.29364140
72ER_23166858_ChIP-Seq_MCF-7_Human1.28067319
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27885467
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27161038
75REST_21632747_ChIP-Seq_MESCs_Mouse1.25906796
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25789928
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.25286819
78* ISL1_27105846_Chip-Seq_CPCs_Mouse1.24500039
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23379708
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22434445
81TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22153606
82RXR_22108803_ChIP-Seq_LS180_Human1.22059931
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.22003428
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21836856
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21836856
86TRIM28_21343339_ChIP-Seq_HEK293_Human1.21545346
87* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20767085
88* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20332213
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19902429
90STAT3_23295773_ChIP-Seq_U87_Human1.17365654
91* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16775776
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.16635456
93* SMAD4_21741376_ChIP-Seq_HESCs_Human1.16456016
94* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15884457
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14350874
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.13242298
97BCAT_22108803_ChIP-Seq_LS180_Human1.10777784
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10548148
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.10364039
100CBP_20019798_ChIP-Seq_JUKART_Human1.10038343
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10038343
102* RING1B_27294783_Chip-Seq_NPCs_Mouse1.09810102
103* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08511772
104CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08318203
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08245074
106* E2F1_18555785_Chip-Seq_ESCs_Mouse1.07806214
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07723779
108* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06019863
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05237253
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05136397
111RUNX2_22187159_ChIP-Seq_PCA_Human1.05038106
112* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04829689
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04018231
114JUN_21703547_ChIP-Seq_K562_Human1.03966195
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.03917379
116* P53_22387025_ChIP-Seq_ESCs_Mouse1.03548467
117EWS_26573619_Chip-Seq_HEK293_Human1.02933864
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02249480
119* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01755524
120* EP300_21415370_ChIP-Seq_HL-1_Mouse1.01401035
121TCF4_23295773_ChIP-Seq_U87_Human1.01346840
122TCF4_22108803_ChIP-Seq_LS180_Human1.01176254
123RING1B_27294783_Chip-Seq_ESCs_Mouse1.01175186
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00414517
125SALL1_21062744_ChIP-ChIP_HESCs_Human0.99505715
126* CJUN_26792858_Chip-Seq_BT549_Human0.98961371
127TP53_16413492_ChIP-PET_HCT116_Human0.97828521
128* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97410052
129* CMYC_18555785_Chip-Seq_ESCs_Mouse0.96284571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.09046487
2MP0000566_synostosis3.33107819
3MP0001188_hyperpigmentation3.15629994
4MP0003122_maternal_imprinting3.06282361
5MP0005171_absent_coat_pigmentation2.90173906
6MP0003283_abnormal_digestive_organ2.81537580
7MP0004859_abnormal_synaptic_plasticity2.67924033
8MP0002234_abnormal_pharynx_morphology2.67696718
9MP0003303_peritoneal_inflammation2.62122691
10MP0003890_abnormal_embryonic-extraembry2.55003168
11MP0005248_abnormal_Harderian_gland2.43408446
12MP0003136_yellow_coat_color2.31378791
13MP0003941_abnormal_skin_development2.29738229
14MP0009046_muscle_twitch2.18722443
15MP0003635_abnormal_synaptic_transmissio2.14931909
16MP0001293_anophthalmia2.12874581
17MP0001968_abnormal_touch/_nociception2.11879255
18MP0009745_abnormal_behavioral_response2.11643560
19MP0000383_abnormal_hair_follicle2.05818854
20MP0005423_abnormal_somatic_nervous2.05544529
21MP0002735_abnormal_chemical_nociception2.05534844
22MP0005499_abnormal_olfactory_system2.03350137
23MP0004133_heterotaxia1.97211427
24MP0002063_abnormal_learning/memory/cond1.96881910
25MP0010030_abnormal_orbit_morphology1.89688845
26MP0003119_abnormal_digestive_system1.86088462
27MP0000778_abnormal_nervous_system1.83502940
28MP0002064_seizures1.80197675
29MP0006292_abnormal_olfactory_placode1.79419323
30MP0002697_abnormal_eye_size1.79357714
31MP0009379_abnormal_foot_pigmentation1.76870453
32MP0006276_abnormal_autonomic_nervous1.70498135
33MP0000467_abnormal_esophagus_morphology1.70372399
34MP0002736_abnormal_nociception_after1.69703759
35MP0001286_abnormal_eye_development1.64000877
36MP0001984_abnormal_olfaction1.62652047
37MP0002572_abnormal_emotion/affect_behav1.61215279
38MP0002163_abnormal_gland_morphology1.56241612
39MP0002148_abnormal_hypersensitivity_rea1.53399650
40MP0010678_abnormal_skin_adnexa1.51223603
41* MP0003385_abnormal_body_wall1.48273678
42MP0002184_abnormal_innervation1.47527625
43* MP0004272_abnormal_basement_membrane1.46717474
44MP0003950_abnormal_plasma_membrane1.43852904
45MP0000569_abnormal_digit_pigmentation1.43733151
46MP0003121_genomic_imprinting1.42389231
47MP0005377_hearing/vestibular/ear_phenot1.41516320
48MP0003878_abnormal_ear_physiology1.41516320
49MP0009780_abnormal_chondrocyte_physiolo1.40238979
50MP0002751_abnormal_autonomic_nervous1.31157913
51MP0004270_analgesia1.29691365
52MP0003315_abnormal_perineum_morphology1.29646000
53MP0004782_abnormal_surfactant_physiolog1.29617499
54MP0002102_abnormal_ear_morphology1.28404620
55MP0005646_abnormal_pituitary_gland1.27801501
56MP0003828_pulmonary_edema1.26838386
57MP0004858_abnormal_nervous_system1.26763846
58MP0003935_abnormal_craniofacial_develop1.26587127
59MP0000462_abnormal_digestive_system1.24389771
60MP0003724_increased_susceptibility_to1.24129251
61MP0001501_abnormal_sleep_pattern1.23494287
62MP0001346_abnormal_lacrimal_gland1.23220032
63MP0001440_abnormal_grooming_behavior1.21665464
64MP0002734_abnormal_mechanical_nocicepti1.19897010
65MP0002928_abnormal_bile_duct1.19700352
66MP0000049_abnormal_middle_ear1.18889852
67MP0002938_white_spotting1.17895788
68MP0001486_abnormal_startle_reflex1.16418918
69MP0002067_abnormal_sensory_capabilities1.15696983
70MP0000579_abnormal_nail_morphology1.15104089
71MP0003787_abnormal_imprinting1.13748505
72MP0005187_abnormal_penis_morphology1.13044413
73MP0000631_abnormal_neuroendocrine_gland1.12416232
74MP0002092_abnormal_eye_morphology1.11833169
75MP0002098_abnormal_vibrissa_morphology1.11029798
76MP0002557_abnormal_social/conspecific_i1.10987501
77MP0009250_abnormal_appendicular_skeleto1.09672636
78MP0002638_abnormal_pupillary_reflex1.09517349
79MP0003755_abnormal_palate_morphology1.08873598
80MP0002282_abnormal_trachea_morphology1.07350962
81MP0001485_abnormal_pinna_reflex1.03991419
82MP0009053_abnormal_anal_canal1.03603904
83MP0004811_abnormal_neuron_physiology1.03583848
84MP0000428_abnormal_craniofacial_morphol1.02541869
85MP0000537_abnormal_urethra_morphology1.02317386
86MP0000516_abnormal_urinary_system1.01709824
87MP0005367_renal/urinary_system_phenotyp1.01709824
88MP0005084_abnormal_gallbladder_morpholo1.01452468
89MP0002272_abnormal_nervous_system1.00649252
90MP0004885_abnormal_endolymph1.00068474
91MP0002733_abnormal_thermal_nociception0.99987588
92MP0000762_abnormal_tongue_morphology0.99956940
93MP0003436_decreased_susceptibility_to0.98733220
94MP0003567_abnormal_fetal_cardiomyocyte0.98702593
95* MP0003861_abnormal_nervous_system0.95427722
96MP0002277_abnormal_respiratory_mucosa0.94881946
97MP0005275_abnormal_skin_tensile0.94044393
98MP0000647_abnormal_sebaceous_gland0.93527117
99MP0005391_vision/eye_phenotype0.93290635
100MP0003115_abnormal_respiratory_system0.93102720
101MP0003123_paternal_imprinting0.92804354
102MP0002177_abnormal_outer_ear0.91624543
103MP0001177_atelectasis0.91452017
104MP0003942_abnormal_urinary_system0.91295524
105MP0002254_reproductive_system_inflammat0.90828056
106MP0009785_altered_susceptibility_to0.88787062
107MP0004742_abnormal_vestibular_system0.88124844
108MP0001970_abnormal_pain_threshold0.87813738
109MP0002111_abnormal_tail_morphology0.86367201
110MP0002653_abnormal_ependyma_morphology0.86068599
111MP0000372_irregular_coat_pigmentation0.85606472
112MP0000955_abnormal_spinal_cord0.85560376
113MP0000432_abnormal_head_morphology0.85293860
114MP0001529_abnormal_vocalization0.84559606
115MP0001299_abnormal_eye_distance/0.84419792
116MP0005645_abnormal_hypothalamus_physiol0.83056804
117MP0002109_abnormal_limb_morphology0.82152155
118MP0002932_abnormal_joint_morphology0.81736675
119MP0008995_early_reproductive_senescence0.80969279
120MP0002233_abnormal_nose_morphology0.80439892
121MP0000534_abnormal_ureter_morphology0.78826093
122* MP0002084_abnormal_developmental_patter0.78767673
123MP0001340_abnormal_eyelid_morphology0.78515568
124MP0002249_abnormal_larynx_morphology0.78457396
125MP0003938_abnormal_ear_development0.78109954
126MP0001958_emphysema0.77207827
127MP0003448_altered_tumor_morphology0.75634994
128MP0002752_abnormal_somatic_nervous0.75523669
129MP0009764_decreased_sensitivity_to0.75283307
130MP0005623_abnormal_meninges_morphology0.73992351
131MP0001835_abnormal_antigen_presentation0.73941795
132MP0005195_abnormal_posterior_eye0.73541316
133MP0002882_abnormal_neuron_morphology0.72916827
134MP0005000_abnormal_immune_tolerance0.71927397
135MP0002152_abnormal_brain_morphology0.71541376
136MP0000538_abnormal_urinary_bladder0.71478484
137MP0000026_abnormal_inner_ear0.70985260
138MP0009384_cardiac_valve_regurgitation0.69554562
139MP0002116_abnormal_craniofacial_bone0.69400929
140MP0004883_abnormal_blood_vessel0.69364531
141MP0004924_abnormal_behavior0.69322958
142MP0005386_behavior/neurological_phenoty0.69322958
143MP0000015_abnormal_ear_pigmentation0.69060517
144MP0009703_decreased_birth_body0.69005300
145MP0003937_abnormal_limbs/digits/tail_de0.68989462
146MP0008789_abnormal_olfactory_epithelium0.68802780
147MP0005167_abnormal_blood-brain_barrier0.68433563
148MP0008004_abnormal_stomach_pH0.68173642
149MP0005394_taste/olfaction_phenotype0.67889877
150MP0004264_abnormal_extraembryonic_tissu0.67439982
151MP0002081_perinatal_lethality0.66925499
152MP0004215_abnormal_myocardial_fiber0.66919482
153MP0005253_abnormal_eye_physiology0.66740812

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.20640168
2Atonic seizures (HP:0010819)3.72263973
3Epileptic encephalopathy (HP:0200134)3.64733247
4Febrile seizures (HP:0002373)3.64560721
5Hyperventilation (HP:0002883)3.41046546
6True hermaphroditism (HP:0010459)3.11906175
7Hypoplastic labia majora (HP:0000059)3.01733674
8Abnormality of the nasal septum (HP:0000419)2.97247067
9Bilateral microphthalmos (HP:0007633)2.89295304
10Esophageal atresia (HP:0002032)2.85996583
11Absence seizures (HP:0002121)2.81934585
12Septo-optic dysplasia (HP:0100842)2.81330494
13Focal seizures (HP:0007359)2.79024674
14Hypoplastic female external genitalia (HP:0012815)2.75360951
15Aplasia cutis congenita (HP:0001057)2.70747720
16Abnormality of the labia majora (HP:0012881)2.68703963
17Myokymia (HP:0002411)2.62380484
18Dialeptic seizures (HP:0011146)2.59755251
19Abnormality of incisor morphology (HP:0011063)2.59554674
20Hepatoblastoma (HP:0002884)2.57821047
21Mediastinal lymphadenopathy (HP:0100721)2.56855282
22Abnormal hair whorl (HP:0010721)2.56059496
23Bifid tongue (HP:0010297)2.50158483
24Onycholysis (HP:0001806)2.49294314
25Anterior segment dysgenesis (HP:0007700)2.47986610
26Calf muscle hypertrophy (HP:0008981)2.46773437
27Absent speech (HP:0001344)2.46451314
28Conical tooth (HP:0000698)2.46194347
29Preaxial foot polydactyly (HP:0001841)2.45491428
30Prostate neoplasm (HP:0100787)2.45293778
31Milia (HP:0001056)2.44106822
32Hypoplastic pelvis (HP:0008839)2.44078318
33Thick nail (HP:0001805)2.42476640
34Gastrointestinal atresia (HP:0002589)2.38286479
35Alacrima (HP:0000522)2.36816521
36Midline defect of the nose (HP:0004122)2.36376797
37Recurrent abscess formation (HP:0002722)2.35935089
38Stomach cancer (HP:0012126)2.35718556
39Heterochromia iridis (HP:0001100)2.34800929
40Eczematoid dermatitis (HP:0000976)2.34131867
41Absent eyebrow (HP:0002223)2.33755118
42Pancreatic cysts (HP:0001737)2.33497915
43Intestinal atresia (HP:0011100)2.32531344
44Cerebellar dysplasia (HP:0007033)2.32311595
45Oligodactyly (hands) (HP:0001180)2.31658925
46Optic neuritis (HP:0100653)2.31097659
47Retrobulbar optic neuritis (HP:0100654)2.31097659
48Renal hypoplasia (HP:0000089)2.30862201
49Tubular atrophy (HP:0000092)2.30588486
50Abnormality of the ischium (HP:0003174)2.29116593
51Narrow nasal bridge (HP:0000446)2.28485609
52Broad-based gait (HP:0002136)2.28368686
53Decreased lacrimation (HP:0000633)2.26299936
54Pancreatic fibrosis (HP:0100732)2.25422748
55Chronic hepatic failure (HP:0100626)2.24154744
56Inability to walk (HP:0002540)2.23419243
57Exercise-induced muscle cramps (HP:0003710)2.21948334
58Atrophic scars (HP:0001075)2.17274301
59Abnormality of the nasolacrimal system (HP:0000614)2.14606499
60Muscle hypertrophy of the lower extremities (HP:0008968)2.14033529
61Increased number of teeth (HP:0011069)2.13751653
62Progressive cerebellar ataxia (HP:0002073)2.13197043
63Split foot (HP:0001839)2.12085278
64Coronal craniosynostosis (HP:0004440)2.11079052
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.10671322
66Parakeratosis (HP:0001036)2.10632349
67Abnormality of nail color (HP:0100643)2.08477525
68Short tibia (HP:0005736)2.08267782
69Drooling (HP:0002307)2.07983541
70Excessive salivation (HP:0003781)2.07983541
71Abnormality of the lacrimal duct (HP:0011481)2.07654446
72Failure to thrive in infancy (HP:0001531)2.06880582
73Gait imbalance (HP:0002141)2.06711175
74Maternal diabetes (HP:0009800)2.06236038
75Thickened helices (HP:0000391)2.05739804
76Nephronophthisis (HP:0000090)2.05356269
77Abnormality of salivation (HP:0100755)2.04512651
78Congenital sensorineural hearing impairment (HP:0008527)2.04001143
79Tubulointerstitial abnormality (HP:0001969)2.02288810
80Choroideremia (HP:0001139)2.01818694
81Molar tooth sign on MRI (HP:0002419)2.00420780
82Abnormality of midbrain morphology (HP:0002418)2.00420780
83Tubulointerstitial fibrosis (HP:0005576)1.98272547
84Congenital primary aphakia (HP:0007707)1.97709465
85Xerostomia (HP:0000217)1.97570872
86Generalized tonic-clonic seizures (HP:0002069)1.96884215
87Vaginal atresia (HP:0000148)1.95643934
88Abnormality of the renal medulla (HP:0100957)1.94516702
89Protruding tongue (HP:0010808)1.94473956
90Medial flaring of the eyebrow (HP:0010747)1.94293340
91Papillary thyroid carcinoma (HP:0002895)1.93418494
92Vitreoretinal degeneration (HP:0000655)1.93093379
93Plantar hyperkeratosis (HP:0007556)1.92971084
94Recurrent gram-negative bacterial infections (HP:0005420)1.92484766
95Orchitis (HP:0100796)1.91036630
96Nasolacrimal duct obstruction (HP:0000579)1.90515701
97Epidermoid cyst (HP:0200040)1.88632118
98Abnormality of the renal cortex (HP:0011035)1.87384002
99Aplasia involving bones of the upper limbs (HP:0009823)1.87082176
100Aplasia of the phalanges of the hand (HP:0009802)1.87082176
101Aplasia involving bones of the extremities (HP:0009825)1.87082176
102Cutaneous syndactyly (HP:0012725)1.85440083
103Genital tract atresia (HP:0001827)1.85433027
104Optic nerve hypoplasia (HP:0000609)1.85138064
105Specific learning disability (HP:0001328)1.85083026
106Postaxial hand polydactyly (HP:0001162)1.84207107
107Abnormality of the middle phalanges of the toes (HP:0010183)1.83963198
108Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82628167
109Vertebral hypoplasia (HP:0008417)1.82628167
110Tubulointerstitial nephritis (HP:0001970)1.82547901
111Abnormality of the labia (HP:0000058)1.81977881
112Cutaneous finger syndactyly (HP:0010554)1.81650343
113Bicornuate uterus (HP:0000813)1.80442484
114Amblyopia (HP:0000646)1.79368425
115Recurrent corneal erosions (HP:0000495)1.78799258
116Limb dystonia (HP:0002451)1.78484552
117Disproportionate short-trunk short stature (HP:0003521)1.78395010
118Nephrogenic diabetes insipidus (HP:0009806)1.78179034
119Exotropia (HP:0000577)1.77658251
120Anophthalmia (HP:0000528)1.76417362
121Postaxial foot polydactyly (HP:0001830)1.76132300
122Myelomeningocele (HP:0002475)1.76118706
123Progressive inability to walk (HP:0002505)1.76044742
124Renal cortical cysts (HP:0000803)1.74885262
125Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74697411
126Recurrent bacterial skin infections (HP:0005406)1.74096421
127Popliteal pterygium (HP:0009756)1.73893397
128Alveolar cell carcinoma (HP:0006519)1.73723259
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.73192992
130Right ventricular cardiomyopathy (HP:0011663)1.73054309
131Broad toe (HP:0001837)1.71393621
132Hypodontia (HP:0000668)1.70800757
133Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70569666
134Hip dysplasia (HP:0001385)1.70395695
135Arterial tortuosity (HP:0005116)1.70122844
136Oligodactyly (HP:0012165)1.69638447
137Absent septum pellucidum (HP:0001331)1.69443989
138Concave nail (HP:0001598)1.68680521
139Ulnar claw (HP:0001178)1.68425510
140Humeroradial synostosis (HP:0003041)1.68305261
141Synostosis involving the elbow (HP:0003938)1.68305261
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.68243936
143Cystic liver disease (HP:0006706)1.68072207
144Sclerocornea (HP:0000647)1.67632144
145Anal stenosis (HP:0002025)1.66955283
146Cupped ear (HP:0000378)1.66670394
147Polyphagia (HP:0002591)1.66524734
148Morphological abnormality of the middle ear (HP:0008609)1.66468658
149Intellectual disability, moderate (HP:0002342)1.65890284
150Shoulder girdle muscle weakness (HP:0003547)1.65876498
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65610596
152Anhidrosis (HP:0000970)1.65363838
153Long nose (HP:0003189)1.65187671
154Stomatitis (HP:0010280)1.65141925
155Labial hypoplasia (HP:0000066)1.64860851
156Growth hormone deficiency (HP:0000824)1.64211632
157Porencephaly (HP:0002132)1.63726419
158Neoplasm of the adrenal cortex (HP:0100641)1.63558609
159Bronchomalacia (HP:0002780)1.62372245
160Hypoplasia of the ulna (HP:0003022)1.59743212
161Abnormality of the labia minora (HP:0012880)1.59621465
162Uterine leiomyosarcoma (HP:0002891)1.59113176
163Leiomyosarcoma (HP:0100243)1.59113176
164Fragile nails (HP:0001808)1.59000628
165Occipital encephalocele (HP:0002085)1.58986445
166Mixed hearing impairment (HP:0000410)1.58844286
167Preaxial hand polydactyly (HP:0001177)1.58832405
168Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.58678753
169Short 4th metacarpal (HP:0010044)1.58678753
170Severe Myopia (HP:0011003)1.58361046
171Oligodontia (HP:0000677)1.57838922
172Hyperglycinemia (HP:0002154)1.57544670
173Asymmetry of the thorax (HP:0001555)1.56412724
174Aqueductal stenosis (HP:0002410)1.56266102
175Subacute progressive viral hepatitis (HP:0006572)1.55057773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.37861655
2PNCK3.69561382
3EPHB22.83610023
4RIPK42.82541239
5MAP3K122.72881385
6EPHA42.63609342
7SIK32.55583844
8PLK22.47709236
9MAPK152.38370450
10MAP3K142.25964004
11BCR2.24702799
12AKT32.19222723
13NTRK32.09488411
14WEE12.01422946
15YES11.89836966
16MARK11.89662857
17MAP2K71.83815537
18PBK1.81937706
19KSR11.77919010
20ERBB31.72804437
21TRIM281.66813166
22BRD41.57807631
23FER1.57493355
24MAPKAPK51.57255311
25BMPR21.55047412
26EPHA31.52800518
27FGFR21.52611089
28MINK11.49381390
29INSRR1.46044320
30DAPK21.44766406
31TGFBR11.43563169
32LMTK21.41769956
33LATS11.38617166
34NTRK21.33944410
35PRPF4B1.32960644
36MAPK131.31968568
37BRSK21.30939027
38PKN21.30297825
39ACVR1B1.29892592
40MAP3K41.28722081
41ERBB41.27391111
42FLT31.27135636
43MAP3K91.14643811
44MST41.14576632
45STK38L1.10235684
46MET1.09389574
47PRKCE1.04840923
48PIM21.03788980
49WNK31.03147407
50ARAF1.02980745
51MST1R1.01467187
52BMPR1B0.97627158
53CSNK1G10.94494504
54GRK10.92044431
55PINK10.89254562
56FES0.88902116
57TAOK20.88477897
58SGK20.88361403
59BRAF0.87464349
60TYRO30.87359094
61OBSCN0.87164988
62VRK10.87131533
63NTRK10.84928115
64CAMK2A0.84453029
65CCNB10.80237083
66SGK2230.79050533
67SGK4940.79050533
68DAPK10.77940690
69LATS20.74248224
70FGFR10.74158282
71ERBB20.74003455
72CDK80.73194721
73CHUK0.72797207
74MAP4K20.72704433
75PLK40.72423467
76BLK0.72400802
77DYRK20.72040809
78PRKCG0.70166922
79TBK10.69166645
80GRK50.69050005
81EIF2AK20.68164104
82STK30.67761817
83IKBKB0.67401051
84STK390.67118782
85CDK50.66784221
86MAP2K40.66478166
87FRK0.64923049
88CDK30.63890886
89ADRBK20.62955178
90BMX0.62785019
91NUAK10.62455987
92LIMK10.62228891
93PAK30.62015999
94CDK140.60204289
95SGK10.58919411
96DYRK30.58545808
97TIE10.56283325
98TSSK60.55971557
99MAP3K50.54017321
100CAMK2B0.53455999
101ADRBK10.53316543
102CDK180.53226832
103PKN10.52243790
104MUSK0.52165064
105NLK0.50426197
106FGFR30.49635481
107PLK30.49514782
108PDGFRA0.49510484
109MAP3K20.47668050
110CAMK1G0.47404635
111MELK0.47098756
112PDK20.46353317
113STK240.46158954
114ROCK10.45936779
115EPHA20.45683614
116TXK0.45631221
117PRKACB0.45592909
118CDK190.44846811
119PRKCZ0.44673911
120CSNK1A1L0.44508808
121PTK2B0.43993916
122GRK70.43147391
123DAPK30.43136894
124IRAK20.42139301
125RPS6KA20.41242045
126TNIK0.41108832
127CSNK1G20.40911733
128FGR0.40217162
129PAK60.40168393
130MAP3K100.39718816
131OXSR10.39678071
132CSNK1G30.39422917
133CSNK1D0.38779522
134PIK3CA0.38474623
135DMPK0.38193833
136MKNK10.37999938
137MYLK0.37935422
138CDK150.36957073
139UHMK10.36785297
140ROCK20.36246419
141NEK90.31901481
142PRKCD0.31838686
143NEK60.31793664
144IRAK10.31688203
145MKNK20.31211957
146DDR20.30833145
147FYN0.30641764
148CAMKK20.29591342

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.87998523
2Steroid biosynthesis_Homo sapiens_hsa001002.77854665
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.62906326
4Collecting duct acid secretion_Homo sapiens_hsa049662.61322029
5Rheumatoid arthritis_Homo sapiens_hsa053232.56904207
6Synaptic vesicle cycle_Homo sapiens_hsa047212.55491174
7Graft-versus-host disease_Homo sapiens_hsa053322.46835417
8Type I diabetes mellitus_Homo sapiens_hsa049402.09954989
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09350178
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02878775
11ECM-receptor interaction_Homo sapiens_hsa045121.96732670
12Butanoate metabolism_Homo sapiens_hsa006501.90534766
13Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.90247618
14Propanoate metabolism_Homo sapiens_hsa006401.89231278
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.87717761
16Protein export_Homo sapiens_hsa030601.86934153
17Phagosome_Homo sapiens_hsa041451.76915342
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.70840730
19Vibrio cholerae infection_Homo sapiens_hsa051101.70764730
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65686581
21Legionellosis_Homo sapiens_hsa051341.59832654
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57140716
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.49492437
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45932636
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45145908
26Morphine addiction_Homo sapiens_hsa050321.44595005
27Allograft rejection_Homo sapiens_hsa053301.44276714
28GABAergic synapse_Homo sapiens_hsa047271.43177776
29African trypanosomiasis_Homo sapiens_hsa051431.42577284
30Axon guidance_Homo sapiens_hsa043601.39443188
31Circadian entrainment_Homo sapiens_hsa047131.38004369
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37374390
33Salmonella infection_Homo sapiens_hsa051321.36872209
34Long-term depression_Homo sapiens_hsa047301.36074847
35Leishmaniasis_Homo sapiens_hsa051401.35555286
36Nitrogen metabolism_Homo sapiens_hsa009101.33043379
37Tuberculosis_Homo sapiens_hsa051521.32144648
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31507663
39Glutamatergic synapse_Homo sapiens_hsa047241.26749694
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24061890
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24042304
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22735092
43Malaria_Homo sapiens_hsa051441.22524092
44TNF signaling pathway_Homo sapiens_hsa046681.21701406
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21699855
46Tryptophan metabolism_Homo sapiens_hsa003801.20618845
47Renin secretion_Homo sapiens_hsa049241.19649621
48Protein digestion and absorption_Homo sapiens_hsa049741.18583595
49Long-term potentiation_Homo sapiens_hsa047201.18420874
50Serotonergic synapse_Homo sapiens_hsa047261.17228512
51Amphetamine addiction_Homo sapiens_hsa050311.16096601
52Olfactory transduction_Homo sapiens_hsa047401.15099619
53Dopaminergic synapse_Homo sapiens_hsa047281.14512695
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14374855
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14150862
56beta-Alanine metabolism_Homo sapiens_hsa004101.13529349
57Pertussis_Homo sapiens_hsa051331.12684142
58Tight junction_Homo sapiens_hsa045301.12676250
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12632345
60Selenocompound metabolism_Homo sapiens_hsa004501.12552801
61Retinol metabolism_Homo sapiens_hsa008301.10887189
62Basal cell carcinoma_Homo sapiens_hsa052171.07555004
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.07085624
64Histidine metabolism_Homo sapiens_hsa003401.05038161
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04528011
66Fat digestion and absorption_Homo sapiens_hsa049751.04000593
67Asthma_Homo sapiens_hsa053101.01623456
68Pyruvate metabolism_Homo sapiens_hsa006201.01466674
69Oxidative phosphorylation_Homo sapiens_hsa001901.01231238
70Salivary secretion_Homo sapiens_hsa049701.00898897
71Peroxisome_Homo sapiens_hsa041460.99980708
72Linoleic acid metabolism_Homo sapiens_hsa005910.98890900
73Cholinergic synapse_Homo sapiens_hsa047250.96993733
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96670525
75Ether lipid metabolism_Homo sapiens_hsa005650.96513108
76Chemical carcinogenesis_Homo sapiens_hsa052040.96426382
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96251634
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95246158
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95088234
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93887227
81Cocaine addiction_Homo sapiens_hsa050300.93652952
82Taste transduction_Homo sapiens_hsa047420.92782569
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90993007
84Autoimmune thyroid disease_Homo sapiens_hsa053200.90536667
85Amoebiasis_Homo sapiens_hsa051460.90270371
86Oxytocin signaling pathway_Homo sapiens_hsa049210.90237766
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90164512
88Hippo signaling pathway_Homo sapiens_hsa043900.89216875
89Fatty acid degradation_Homo sapiens_hsa000710.89097528
90Vitamin digestion and absorption_Homo sapiens_hsa049770.87530956
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87438409
92Melanogenesis_Homo sapiens_hsa049160.87433261
93Osteoclast differentiation_Homo sapiens_hsa043800.86932227
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86373555
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85996194
96Calcium signaling pathway_Homo sapiens_hsa040200.85571550
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85420566
98ErbB signaling pathway_Homo sapiens_hsa040120.84627365
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.83641595
100Hedgehog signaling pathway_Homo sapiens_hsa043400.82655426
101Gap junction_Homo sapiens_hsa045400.80532596
102MAPK signaling pathway_Homo sapiens_hsa040100.75363161
103Phototransduction_Homo sapiens_hsa047440.74606443
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74562924
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74214557
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73988932
107Dilated cardiomyopathy_Homo sapiens_hsa054140.73852421
108Caffeine metabolism_Homo sapiens_hsa002320.73561807
109Chemokine signaling pathway_Homo sapiens_hsa040620.73457243
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72893193
111Parkinsons disease_Homo sapiens_hsa050120.72083282
112Melanoma_Homo sapiens_hsa052180.71799487
113Type II diabetes mellitus_Homo sapiens_hsa049300.71347189
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70665227
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69578117
116Glycerolipid metabolism_Homo sapiens_hsa005610.69348631
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68971188
118Arginine and proline metabolism_Homo sapiens_hsa003300.68894428
119Gastric acid secretion_Homo sapiens_hsa049710.68762147
120Complement and coagulation cascades_Homo sapiens_hsa046100.67946036
121Cardiac muscle contraction_Homo sapiens_hsa042600.67648829
122PPAR signaling pathway_Homo sapiens_hsa033200.65483319
123Toxoplasmosis_Homo sapiens_hsa051450.63507274
124Influenza A_Homo sapiens_hsa051640.63195193
125Proteoglycans in cancer_Homo sapiens_hsa052050.62462800
126TGF-beta signaling pathway_Homo sapiens_hsa043500.62003911
127Focal adhesion_Homo sapiens_hsa045100.61875122
128Huntingtons disease_Homo sapiens_hsa050160.60748067
129Hematopoietic cell lineage_Homo sapiens_hsa046400.59884053
130Wnt signaling pathway_Homo sapiens_hsa043100.59844110
131Shigellosis_Homo sapiens_hsa051310.59817181
132Fatty acid metabolism_Homo sapiens_hsa012120.59512122
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59193282
134GnRH signaling pathway_Homo sapiens_hsa049120.59145283
135Basal transcription factors_Homo sapiens_hsa030220.58271134
136Rap1 signaling pathway_Homo sapiens_hsa040150.58106143
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58096725
138Alzheimers disease_Homo sapiens_hsa050100.57994536
139Glioma_Homo sapiens_hsa052140.57878895
140cAMP signaling pathway_Homo sapiens_hsa040240.57273392
141Insulin secretion_Homo sapiens_hsa049110.56943685
142Fanconi anemia pathway_Homo sapiens_hsa034600.55643481
143Pathways in cancer_Homo sapiens_hsa052000.54171570
144Endometrial cancer_Homo sapiens_hsa052130.53692684
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53558352
146Adherens junction_Homo sapiens_hsa045200.53481808
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53397863
148Bile secretion_Homo sapiens_hsa049760.53217904
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.52804994
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.52087307
151Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51636642
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51216754
153Dorso-ventral axis formation_Homo sapiens_hsa043200.51116792
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50222628
155ABC transporters_Homo sapiens_hsa020100.49950732
156Colorectal cancer_Homo sapiens_hsa052100.49843428
157Prion diseases_Homo sapiens_hsa050200.49227881
158Measles_Homo sapiens_hsa051620.49036997
159Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48799327
160Phenylalanine metabolism_Homo sapiens_hsa003600.48033643
161Ras signaling pathway_Homo sapiens_hsa040140.47151207
162Mineral absorption_Homo sapiens_hsa049780.45666411
163Tyrosine metabolism_Homo sapiens_hsa003500.45633143
164PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44885306
165Lysine degradation_Homo sapiens_hsa003100.44200447
166Cysteine and methionine metabolism_Homo sapiens_hsa002700.43303834
167Ovarian steroidogenesis_Homo sapiens_hsa049130.42634377
168Glutathione metabolism_Homo sapiens_hsa004800.41845072
169Sphingolipid metabolism_Homo sapiens_hsa006000.41349758
170Metabolic pathways_Homo sapiens_hsa011000.40972613

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