FLT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.46935282
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.46935282
3antigen processing and presentation of endogenous antigen (GO:0019883)6.04068120
4ribosomal small subunit assembly (GO:0000028)6.00952840
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.65211967
6antigen processing and presentation via MHC class Ib (GO:0002475)5.50308304
7response to peptidoglycan (GO:0032494)5.17623069
8positive regulation of B cell differentiation (GO:0045579)4.73010782
9mast cell activation (GO:0045576)4.64653071
10defense response to protozoan (GO:0042832)4.49476618
11NIK/NF-kappaB signaling (GO:0038061)4.47919759
12platelet dense granule organization (GO:0060155)4.44611046
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42097476
14mast cell degranulation (GO:0043303)4.35147167
15mast cell activation involved in immune response (GO:0002279)4.35147167
16purine deoxyribonucleotide catabolic process (GO:0009155)4.33017841
17viral transcription (GO:0019083)4.28956078
18negative regulation of B cell apoptotic process (GO:0002903)4.25392679
19G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.25137208
20angiogenesis involved in wound healing (GO:0060055)4.19423933
21neutrophil activation involved in immune response (GO:0002283)4.17951983
22positive regulation of T cell mediated cytotoxicity (GO:0001916)4.15716935
23response to protozoan (GO:0001562)4.12068261
24translational termination (GO:0006415)4.03751071
25Peyers patch development (GO:0048541)4.01474795
26mucosal-associated lymphoid tissue development (GO:0048537)4.01474795
27regulation of B cell apoptotic process (GO:0002902)3.95020157
28positive regulation of granulocyte differentiation (GO:0030854)3.94633923
29mature B cell differentiation involved in immune response (GO:0002313)3.89272042
30cellular response to interferon-beta (GO:0035458)3.83940410
31regulation of T cell mediated cytotoxicity (GO:0001914)3.80515656
32response to interferon-beta (GO:0035456)3.77191342
33necroptotic process (GO:0070266)3.75605100
34positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.73748782
35megakaryocyte development (GO:0035855)3.68471597
36immunoglobulin mediated immune response (GO:0016064)3.68462638
37poly(A)+ mRNA export from nucleus (GO:0016973)3.64295132
38DNA deamination (GO:0045006)3.63415183
39negative regulation of granulocyte differentiation (GO:0030853)3.61041062
40telomere maintenance via semi-conservative replication (GO:0032201)3.59583964
41regulation of myeloid leukocyte mediated immunity (GO:0002886)3.59547829
42positive thymic T cell selection (GO:0045059)3.58681578
43negative regulation of interleukin-17 production (GO:0032700)3.57784942
44translational elongation (GO:0006414)3.57726676
45positive regulation of gamma-delta T cell activation (GO:0046645)3.57577144
46negative regulation of erythrocyte differentiation (GO:0045647)3.56242232
47regulation of T-helper 1 cell differentiation (GO:0045625)3.56200141
48purinergic nucleotide receptor signaling pathway (GO:0035590)3.55387023
49mature B cell differentiation (GO:0002335)3.54350205
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54269538
51positive regulation of response to tumor cell (GO:0002836)3.52555851
52positive regulation of immune response to tumor cell (GO:0002839)3.52555851
53regulation of immune response to tumor cell (GO:0002837)3.52555851
54regulation of response to tumor cell (GO:0002834)3.52555851
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.50893884
56negative regulation of T-helper cell differentiation (GO:0045623)3.46676405
57negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.46676405
58cotranslational protein targeting to membrane (GO:0006613)3.46509555
59maturation of SSU-rRNA (GO:0030490)3.45666238
60regulation of leukocyte degranulation (GO:0043300)3.43148399
61protein targeting to ER (GO:0045047)3.42082349
62T cell homeostasis (GO:0043029)3.39114443
63response to muramyl dipeptide (GO:0032495)3.37485602
64negative regulation of type 2 immune response (GO:0002829)3.37271999
65positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.37006522
66regulation of B cell receptor signaling pathway (GO:0050855)3.36510634
67definitive hemopoiesis (GO:0060216)3.36097253
68positive regulation of mast cell activation involved in immune response (GO:0033008)3.34296578
69positive regulation of mast cell degranulation (GO:0043306)3.34296578
70* regulation of B cell differentiation (GO:0045577)3.33909955
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30743681
72cell differentiation involved in metanephros development (GO:0072202)3.29061927
73* lymphoid progenitor cell differentiation (GO:0002320)3.28218147
74leukocyte degranulation (GO:0043299)3.26475294
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24999869
76establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24832517
77regulation of mast cell degranulation (GO:0043304)3.23783951
78ribosomal small subunit biogenesis (GO:0042274)3.23686836
79protein localization to endoplasmic reticulum (GO:0070972)3.22304696
80cellular extravasation (GO:0045123)3.20894135
81regulation of necroptotic process (GO:0060544)3.19372690
82response to hydroperoxide (GO:0033194)3.17469805
83positive regulation of natural killer cell activation (GO:0032816)3.16816307
84regulation of granulocyte differentiation (GO:0030852)3.16393172
85regulation of hypersensitivity (GO:0002883)3.15073003
86B cell receptor signaling pathway (GO:0050853)3.14956089
87regulation of gamma-delta T cell activation (GO:0046643)3.14577213
88deoxyribonucleotide catabolic process (GO:0009264)3.14324550
89myeloid dendritic cell activation (GO:0001773)3.12975758
90DNA strand elongation involved in DNA replication (GO:0006271)3.12843089
91response to UV-B (GO:0010224)3.12657379
92viral life cycle (GO:0019058)3.11755875
93positive regulation of T-helper cell differentiation (GO:0045624)3.10613066
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09571671
95regulation of T cell receptor signaling pathway (GO:0050856)3.08350811
96myeloid cell activation involved in immune response (GO:0002275)3.08012416
97regulation of RIG-I signaling pathway (GO:0039535)3.07975971
98telomere maintenance via recombination (GO:0000722)3.07332981
99B cell mediated immunity (GO:0019724)3.06928304
100DNA strand elongation (GO:0022616)3.06775579
101programmed necrotic cell death (GO:0097300)3.06264254
102deoxyribose phosphate catabolic process (GO:0046386)3.05566636
103purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.04200229
104positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.04047949
105regulation of gamma-delta T cell differentiation (GO:0045586)3.03584210
106regulation of mast cell activation (GO:0033003)3.03325407
107regulation of germinal center formation (GO:0002634)3.03062882
108secretory granule organization (GO:0033363)3.02278583
109positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00888021
110T cell migration (GO:0072678)3.00495052
111cellular protein complex disassembly (GO:0043624)2.99376772
112regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99249978
113germinal center formation (GO:0002467)2.99178565
114regulation of mast cell activation involved in immune response (GO:0033006)2.98503737
115positive regulation of mast cell activation (GO:0033005)2.96364111
116purine deoxyribonucleotide metabolic process (GO:0009151)2.95368023
117regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95128435
118regulation of natural killer cell activation (GO:0032814)2.93768785
119regulation of female gonad development (GO:2000194)2.93344647
120positive regulation of alpha-beta T cell differentiation (GO:0046638)2.91927878
121epithelial cell differentiation involved in kidney development (GO:0035850)2.91145435
122negative regulation of nitric oxide biosynthetic process (GO:0045019)2.89738346
123type I interferon signaling pathway (GO:0060337)2.89013335
124cellular response to type I interferon (GO:0071357)2.89013335
125pinocytosis (GO:0006907)2.88215750
126regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87424730
127regulation of interleukin-12 biosynthetic process (GO:0045075)2.87205060
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.86706507
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.86706507
130modulation by symbiont of host immune response (GO:0052553)2.86706507
131positive regulation by symbiont of host defense response (GO:0052509)2.86706507
132modulation by symbiont of host defense response (GO:0052031)2.86706507
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.86706507
134histamine secretion (GO:0001821)2.86088440
135response to type I interferon (GO:0034340)2.85903311
136regulation of regulated secretory pathway (GO:1903305)2.85584451
137cellular response to exogenous dsRNA (GO:0071360)2.84931410
138regulation of antigen processing and presentation (GO:0002577)2.83191258
139endothelium development (GO:0003158)2.82942533
140negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81745039
141negative regulation of necroptotic process (GO:0060546)2.81490563
142lymphocyte homeostasis (GO:0002260)2.81435884
143negative regulation of phagocytosis (GO:0050765)2.80259094
144regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.79667401
145negative regulation of interleukin-12 production (GO:0032695)2.79397171
146positive regulation of B cell activation (GO:0050871)2.77047042
147myeloid dendritic cell differentiation (GO:0043011)2.76977092
148negative thymic T cell selection (GO:0045060)2.76785053
149necrotic cell death (GO:0070265)2.74981097
150negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.74601152
151modulation of growth of symbiont involved in interaction with host (GO:0044144)2.74601152
152regulation of growth of symbiont in host (GO:0044126)2.74601152
153negative regulation of growth of symbiont in host (GO:0044130)2.74601152
154protein complex disassembly (GO:0043241)2.73639618
155positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73628862
156polyketide metabolic process (GO:0030638)2.73376873
157doxorubicin metabolic process (GO:0044598)2.73376873
158daunorubicin metabolic process (GO:0044597)2.73376873
159interferon-gamma-mediated signaling pathway (GO:0060333)2.73353112
160mitotic recombination (GO:0006312)2.72448012
161* leukocyte homeostasis (GO:0001776)2.71928899
162cell wall macromolecule catabolic process (GO:0016998)2.71677471
163regulation of T-helper 2 cell differentiation (GO:0045628)2.71620456
164microglial cell activation (GO:0001774)2.71228736
165neutrophil activation (GO:0042119)2.71218106
166regulation of interleukin-17 production (GO:0032660)2.71109968
167dosage compensation (GO:0007549)2.70978724
168positive regulation of antigen processing and presentation (GO:0002579)2.68089194
169regulation of necrotic cell death (GO:0010939)2.67197465
170Arp2/3 complex-mediated actin nucleation (GO:0034314)2.64375301
171telomere maintenance via telomere lengthening (GO:0010833)2.64197045
172regulation of histone phosphorylation (GO:0033127)2.63733626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.22020694
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.56644724
3SCL_19346495_ChIP-Seq_HPC-7_Human3.99975511
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.68419332
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45155938
6GATA1_22025678_ChIP-Seq_K562_Human3.39064519
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.23684761
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.20467527
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.15123447
10FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.75431454
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68080323
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.67340121
13VDR_21846776_ChIP-Seq_THP-1_Human2.64520756
14TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.59485346
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57394380
16MYC_22102868_ChIP-Seq_BL_Human2.49743649
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48529015
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46763820
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.46044669
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43429188
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.40378410
22SPI1_23547873_ChIP-Seq_NB4_Human2.37055685
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.19366194
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18893947
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.15899822
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.15160291
27ERG_20887958_ChIP-Seq_HPC-7_Mouse2.12069015
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.10659834
29SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.10320995
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05716914
31VDR_24763502_ChIP-Seq_THP-1_Human2.05540818
32MYB_26560356_Chip-Seq_TH2_Human2.04810363
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.04711485
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03456049
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.01768601
36RUNX_20019798_ChIP-Seq_JUKART_Human1.96018923
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.95482450
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94151692
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93552413
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89743477
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.88681698
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88667605
43VDR_24787735_ChIP-Seq_THP-1_Human1.88095495
44MAF_26560356_Chip-Seq_TH1_Human1.86826474
45CIITA_25753668_ChIP-Seq_RAJI_Human1.83405852
46MYB_26560356_Chip-Seq_TH1_Human1.83080192
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78286758
48FOXP3_21729870_ChIP-Seq_TREG_Human1.76633177
49VDR_23849224_ChIP-Seq_CD4+_Human1.76589775
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75981631
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69068484
52TCF7_22412390_ChIP-Seq_EML_Mouse1.67962734
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66520022
54GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.65683855
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65486609
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60330241
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57846748
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57813394
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.57029176
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56136409
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.54541570
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54129433
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53939235
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52276221
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48589428
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47429418
67UTX_26944678_Chip-Seq_JUKART_Human1.46955122
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42544685
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.39513211
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.38854294
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38200219
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37830139
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36031593
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.35558519
75SPI1_23127762_ChIP-Seq_K562_Human1.32614349
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29599788
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29100614
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29046195
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26565695
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26321305
81XRN2_22483619_ChIP-Seq_HELA_Human1.23979096
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22402702
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.20973436
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.19981540
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19920252
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.19048682
87KDM2B_26808549_Chip-Seq_DND41_Human1.17331687
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13940041
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13582380
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13292854
91* GATA3_27048872_Chip-Seq_THYMUS_Human1.11924331
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11811828
93MAF_26560356_Chip-Seq_TH2_Human1.10468979
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06133988
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05583236
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04554333
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02889570
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01862727
99GATA3_26560356_Chip-Seq_TH2_Human1.00924558
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.00726792
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00490303
102E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00338853
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00303905
104BCL6_27268052_Chip-Seq_Bcells_Human1.00165583
105E2F1_21310950_ChIP-Seq_MCF-7_Human0.99543079
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99540363
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99068133
108GABP_19822575_ChIP-Seq_HepG2_Human0.98827822
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98304795
110PU_27001747_Chip-Seq_BMDM_Mouse0.98255944
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.97749673
112NCOR1_26117541_ChIP-Seq_K562_Human0.95282374
113SPI1_20517297_ChIP-Seq_HL60_Human0.94324704
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93367713
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92987723
116ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91958588
117P300_27268052_Chip-Seq_Bcells_Human0.91851618
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91479805
119TTF2_22483619_ChIP-Seq_HELA_Human0.90794963
120CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89411237
121KDM5A_27292631_Chip-Seq_BREAST_Human0.88924290
122ELK1_19687146_ChIP-ChIP_HELA_Human0.86379236
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85719383
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85634220
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85618627
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83226969
127STAT1_20625510_ChIP-Seq_HELA_Human0.82832097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.22681769
2MP0000685_abnormal_immune_system3.90637410
3* MP0002396_abnormal_hematopoietic_system3.90178169
4MP0005174_abnormal_tail_pigmentation3.51996328
5MP0005671_abnormal_response_to2.84600874
6MP0001800_abnormal_humoral_immune2.84071726
7* MP0009785_altered_susceptibility_to2.75149125
8MP0004808_abnormal_hematopoietic_stem2.61614161
9MP0002148_abnormal_hypersensitivity_rea2.57834565
10MP0002166_altered_tumor_susceptibility2.57600361
11* MP0002398_abnormal_bone_marrow2.54585671
12* MP0005025_abnormal_response_to2.54364386
13* MP0002452_abnormal_antigen_presenting2.52960566
14* MP0002420_abnormal_adaptive_immunity2.52437806
15MP0003763_abnormal_thymus_physiology2.51892533
16* MP0002723_abnormal_immune_serum2.50985292
17* MP0001819_abnormal_immune_cell2.49221474
18MP0001545_abnormal_hematopoietic_system2.42765863
19MP0005397_hematopoietic_system_phenotyp2.42765863
20MP0005000_abnormal_immune_tolerance2.39366256
21MP0005075_abnormal_melanosome_morpholog2.37731696
22MP0001873_stomach_inflammation2.35451819
23MP0005464_abnormal_platelet_physiology2.33627294
24MP0003436_decreased_susceptibility_to2.32477309
25MP0001790_abnormal_immune_system2.31459524
26MP0005387_immune_system_phenotype2.31459524
27MP0000716_abnormal_immune_system2.24422138
28MP0002095_abnormal_skin_pigmentation2.16194777
29* MP0002419_abnormal_innate_immunity2.15256360
30* MP0000689_abnormal_spleen_morphology2.08370224
31MP0002006_tumorigenesis2.03435537
32MP0003183_abnormal_peptide_metabolism2.00230714
33MP0003303_peritoneal_inflammation2.00115362
34* MP0002429_abnormal_blood_cell1.99214695
35MP0002722_abnormal_immune_system1.96890274
36MP0004147_increased_porphyrin_level1.90947306
37MP0001853_heart_inflammation1.88183620
38MP0010094_abnormal_chromosome_stability1.83643508
39MP0010155_abnormal_intestine_physiology1.79813185
40MP0005645_abnormal_hypothalamus_physiol1.76011821
41MP0000490_abnormal_crypts_of1.75802825
42MP0002405_respiratory_system_inflammati1.72880602
43MP0008057_abnormal_DNA_replication1.62527628
44MP0003866_abnormal_defecation1.62390979
45MP0000465_gastrointestinal_hemorrhage1.59032129
46* MP0000703_abnormal_thymus_morphology1.54178173
47MP0003172_abnormal_lysosome_physiology1.43483771
48MP0002132_abnormal_respiratory_system1.43240334
49MP0001845_abnormal_inflammatory_respons1.39147230
50MP0000015_abnormal_ear_pigmentation1.39053720
51MP0002254_reproductive_system_inflammat1.38624961
52MP0009333_abnormal_splenocyte_physiolog1.37028790
53MP0003693_abnormal_embryo_hatching1.35511960
54MP0008058_abnormal_DNA_repair1.34653042
55MP0001348_abnormal_lacrimal_gland1.33066129
56MP0002877_abnormal_melanocyte_morpholog1.32492068
57MP0003656_abnormal_erythrocyte_physiolo1.31201541
58MP0003077_abnormal_cell_cycle1.31052648
59MP0002019_abnormal_tumor_incidence1.27679714
60MP0009278_abnormal_bone_marrow1.26786076
61* MP0008469_abnormal_protein_level1.23004786
62MP0000371_diluted_coat_color1.16777518
63MP0001986_abnormal_taste_sensitivity1.16236346
64MP0002933_joint_inflammation1.16115004
65MP0005084_abnormal_gallbladder_morpholo1.15250802
66* MP0008007_abnormal_cellular_replicative1.12318025
67MP0003806_abnormal_nucleotide_metabolis1.11084710
68MP0004947_skin_inflammation1.10971497
69MP0000681_abnormal_thyroid_gland1.05972414
70MP0001188_hyperpigmentation1.04755008
71MP0004510_myositis1.02648379
72MP0003191_abnormal_cellular_cholesterol1.00291458
73MP0003943_abnormal_hepatobiliary_system0.99656455
74MP0002138_abnormal_hepatobiliary_system0.95532768
75MP0009379_abnormal_foot_pigmentation0.95499739
76MP0002998_abnormal_bone_remodeling0.91568485
77MP0000313_abnormal_cell_death0.90936949
78MP0003252_abnormal_bile_duct0.90268419
79MP0004957_abnormal_blastocyst_morpholog0.90152408
80MP0009765_abnormal_xenobiotic_induced0.89560090
81MP0002009_preneoplasia0.88414761
82MP0005310_abnormal_salivary_gland0.88341167
83MP0003075_altered_response_to0.88204562
84MP0003787_abnormal_imprinting0.87465803
85MP0005220_abnormal_exocrine_pancreas0.85473297
86MP0009764_decreased_sensitivity_to0.85431234
87MP0003111_abnormal_nucleus_morphology0.84744058
88MP0002075_abnormal_coat/hair_pigmentati0.83642526
89MP0000343_altered_response_to0.83208103
90MP0006082_CNS_inflammation0.81746147
91MP0003724_increased_susceptibility_to0.77093258
92MP0006292_abnormal_olfactory_placode0.76923052
93MP0002822_catalepsy0.76740877
94MP0000372_irregular_coat_pigmentation0.74530600
95MP0005409_darkened_coat_color0.74281035
96MP0001663_abnormal_digestive_system0.74244706
97MP0009697_abnormal_copulation0.73670822
98MP0001851_eye_inflammation0.72414918
99MP0000598_abnormal_liver_morphology0.71727356
100MP0009763_increased_sensitivity_to0.71503350
101MP0000569_abnormal_digit_pigmentation0.68943597
102MP0002876_abnormal_thyroid_physiology0.65866096
103MP0008877_abnormal_DNA_methylation0.65418374
104MP0005535_abnormal_body_temperature0.65055689
105MP0000350_abnormal_cell_proliferation0.64381443
106MP0003828_pulmonary_edema0.63819912
107MP0003300_gastrointestinal_ulcer0.63584386
108MP0000604_amyloidosis0.63265192
109MP0000858_altered_metastatic_potential0.61793764
110MP0001765_abnormal_ion_homeostasis0.61503086
111MP0003786_premature_aging0.60510705
112MP0005166_decreased_susceptibility_to0.60509893
113MP0005319_abnormal_enzyme/_coenzyme0.60355291
114MP0006036_abnormal_mitochondrial_physio0.58857145
115MP0005379_endocrine/exocrine_gland_phen0.58744447
116MP0004142_abnormal_muscle_tone0.58371466
117MP0001533_abnormal_skeleton_physiology0.57243229
118MP0008873_increased_physiological_sensi0.55541526
119MP0005058_abnormal_lysosome_morphology0.54375309
120MP0008995_early_reproductive_senescence0.53227296
121MP0010307_abnormal_tumor_latency0.53167301
122MP0005646_abnormal_pituitary_gland0.52845874
123MP0000013_abnormal_adipose_tissue0.52563449

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.84273691
2Thrombocytosis (HP:0001894)5.35884187
3Elevated erythrocyte sedimentation rate (HP:0003565)5.32900648
4Myositis (HP:0100614)5.06526801
5Recurrent abscess formation (HP:0002722)4.40898327
6IgM deficiency (HP:0002850)4.38252307
7Panhypogammaglobulinemia (HP:0003139)4.32623896
8Recurrent bacterial skin infections (HP:0005406)4.14015668
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.05971174
10Severe combined immunodeficiency (HP:0004430)3.97428194
11* Acute lymphatic leukemia (HP:0006721)3.90749711
12Recurrent bronchitis (HP:0002837)3.89518426
13Granulocytopenia (HP:0001913)3.80992694
14Agammaglobulinemia (HP:0004432)3.76186143
15Aplastic anemia (HP:0001915)3.69086534
16Reticulocytopenia (HP:0001896)3.66471028
17Recurrent viral infections (HP:0004429)3.51537958
18Autoimmune thrombocytopenia (HP:0001973)3.49264792
19Abnormality of T cell physiology (HP:0011840)3.45991037
20Stomatitis (HP:0010280)3.44225702
21B lymphocytopenia (HP:0010976)3.34011658
22Abnormality of B cell number (HP:0010975)3.34011658
23Colitis (HP:0002583)3.33816876
24Abnormality of cells of the erythroid lineage (HP:0012130)3.30737959
25Autoimmune hemolytic anemia (HP:0001890)3.29831922
26Chronic obstructive pulmonary disease (HP:0006510)3.28862729
27Obstructive lung disease (HP:0006536)3.28862729
28Recurrent fungal infections (HP:0002841)3.23231148
29Inflammation of the large intestine (HP:0002037)3.21186115
30Abnormal number of erythroid precursors (HP:0012131)3.19131241
31Nasal polyposis (HP:0100582)3.17919357
32Gastrointestinal inflammation (HP:0004386)3.17016377
33Meningitis (HP:0001287)3.14877281
34Recurrent skin infections (HP:0001581)3.09434160
35Combined immunodeficiency (HP:0005387)3.03832597
36Interstitial pulmonary disease (HP:0006530)2.99129512
37Hypothermia (HP:0002045)2.97530180
38Gastrointestinal stroma tumor (HP:0100723)2.94737833
39Mediastinal lymphadenopathy (HP:0100721)2.90115523
40Abnormality of the nasal mucosa (HP:0000433)2.86476227
41Cellulitis (HP:0100658)2.82175334
42Aplasia/Hypoplasia of the thymus (HP:0010515)2.81624617
43Poikiloderma (HP:0001029)2.81279056
44Reduced antithrombin III activity (HP:0001976)2.77400251
45Eosinophilia (HP:0001880)2.75708013
46Recurrent cutaneous fungal infections (HP:0011370)2.73206118
47Chronic mucocutaneous candidiasis (HP:0002728)2.73206118
48Type II lissencephaly (HP:0007260)2.70804562
49Chronic sinusitis (HP:0011109)2.68790034
50Fatigue (HP:0012378)2.67346764
51Abnormality of T cells (HP:0002843)2.66746756
52Prostate neoplasm (HP:0100787)2.66410413
53Spondylolisthesis (HP:0003302)2.66053102
54Viral hepatitis (HP:0006562)2.65462449
55Abnormality of macrophages (HP:0004311)2.65274013
56Type I transferrin isoform profile (HP:0003642)2.59607160
57Abnormality of DNA repair (HP:0003254)2.59292779
58Chest pain (HP:0100749)2.59144296
59Leukocytosis (HP:0001974)2.57675656
60IgG deficiency (HP:0004315)2.51426379
61Eczematoid dermatitis (HP:0000976)2.50717420
62Thoracic kyphosis (HP:0002942)2.48902881
63Urticaria (HP:0001025)2.48101173
64Lymphopenia (HP:0001888)2.46547216
65Thyroiditis (HP:0100646)2.44964733
66Encephalitis (HP:0002383)2.41653165
67Hypoplasia of the thymus (HP:0000778)2.41624540
68Abnormality of the prostate (HP:0008775)2.39752945
69Recurrent sinusitis (HP:0011108)2.38311579
70Metaphyseal dysplasia (HP:0100255)2.38067179
71Lymphoma (HP:0002665)2.37031028
72Skin rash (HP:0000988)2.34139867
73Prolonged bleeding time (HP:0003010)2.34114315
74Severe visual impairment (HP:0001141)2.32932082
75Abnormality of cells of the lymphoid lineage (HP:0012140)2.32702299
76* Acute myeloid leukemia (HP:0004808)2.31297762
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30929945
78Chronic diarrhea (HP:0002028)2.29574015
79Abnormality of male internal genitalia (HP:0000022)2.28658744
80Hypoproteinemia (HP:0003075)2.28445349
81Amaurosis fugax (HP:0100576)2.27479234
82Myelodysplasia (HP:0002863)2.25369013
83Pallor (HP:0000980)2.25274417
84Petechiae (HP:0000967)2.24987535
85Gingival bleeding (HP:0000225)2.21427277
86Vasculitis (HP:0002633)2.20983148
87Abnormality of eosinophils (HP:0001879)2.20926099
88Failure to thrive in infancy (HP:0001531)2.20653573
89Abnormality of the columella (HP:0009929)2.20621303
90Erythema (HP:0010783)2.20260128
91Sepsis (HP:0100806)2.19852400
92Amyloidosis (HP:0011034)2.18343744
93Bronchitis (HP:0012387)2.17966668
94Arterial thrombosis (HP:0004420)2.15560762
95Abnormality of the heme biosynthetic pathway (HP:0010472)2.15398894
96Agnosia (HP:0010524)2.13463347
97Syringomyelia (HP:0003396)2.12723251
98Spinal cord lesions (HP:0100561)2.12723251
99Orchitis (HP:0100796)2.12361063
100Abnormality of the thymus (HP:0000777)2.11915125
101Entropion (HP:0000621)2.10297323
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08583383
103Abnormal protein N-linked glycosylation (HP:0012347)2.08583383
104Abnormal protein glycosylation (HP:0012346)2.08583383
105Abnormal glycosylation (HP:0012345)2.08583383
106Albinism (HP:0001022)2.08224840
107Increased IgE level (HP:0003212)2.08201768
108Hemoptysis (HP:0002105)2.07343254
109Epistaxis (HP:0000421)2.07296168
110Osteomyelitis (HP:0002754)2.07252852
111Retrobulbar optic neuritis (HP:0100654)2.04523358
112Optic neuritis (HP:0100653)2.04523358
113Pulmonary infiltrates (HP:0002113)2.03756619
114Hypergammaglobulinemia (HP:0010702)2.03182434
115Neutropenia (HP:0001875)1.98575869
116Self-mutilation (HP:0000742)1.98553235
117Increased neuronal autofluorescent lipopigment (HP:0002074)1.97899550
118Emphysema (HP:0002097)1.97417427
119Thyroid-stimulating hormone excess (HP:0002925)1.97295213
120Chromsome breakage (HP:0040012)1.96584076
121Birth length less than 3rd percentile (HP:0003561)1.96464836
122Stomach cancer (HP:0012126)1.96263386
123Verrucae (HP:0200043)1.92567860
124Papilloma (HP:0012740)1.92567860
125Abnormal platelet function (HP:0011869)1.91058853
126Impaired platelet aggregation (HP:0003540)1.91058853
127Abnormality of the fingertips (HP:0001211)1.90744988
128Increased cerebral lipofuscin (HP:0011813)1.90069492
129Alveolar cell carcinoma (HP:0006519)1.89873918
130Recurrent lower respiratory tract infections (HP:0002783)1.89222953
131Recurrent pneumonia (HP:0006532)1.89089892
132Leukopenia (HP:0001882)1.88935786
133Broad face (HP:0000283)1.87785525
134Exertional dyspnea (HP:0002875)1.87551695
135Cerebellar dysplasia (HP:0007033)1.86796652
136Macrocytic anemia (HP:0001972)1.86538874
137Abolished electroretinogram (ERG) (HP:0000550)1.85542769
138Clubbing of toes (HP:0100760)1.84676740
139Spontaneous hematomas (HP:0007420)1.84648501
14011 pairs of ribs (HP:0000878)1.82649546
141Pulmonary embolism (HP:0002204)1.82384521
142Skin ulcer (HP:0200042)1.81578038
143Dysostosis multiplex (HP:0000943)1.79736522
144Abnormality of the pleura (HP:0002103)1.79514418
145Thrombophlebitis (HP:0004418)1.78943310
146Neoplasm of the tracheobronchial system (HP:0100552)1.78940683
147Thickened calvaria (HP:0002684)1.78865941
148Increased IgM level (HP:0003496)1.78100394
149Hypochromic anemia (HP:0001931)1.77279138
150Decreased central vision (HP:0007663)1.73725065
151Constricted visual fields (HP:0001133)1.71153616
152Cutis marmorata (HP:0000965)1.70441974

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.95264053
2* KIT3.52212107
3TNIK3.21361049
4BRSK22.96262716
5IRAK42.84926138
6TEC2.84260469
7BMPR22.62110463
8ADRBK22.59019260
9PIK3CG2.39065610
10BTK2.35640993
11WEE12.30197370
12NME22.16168416
13ACVR1B2.16000281
14TBK12.14980884
15TGFBR12.10241231
16MAP3K141.92212322
17SYK1.88535063
18PRPF4B1.82067769
19TYK21.81579335
20JAK31.78046343
21CCNB11.77364363
22TNK21.76024312
23EEF2K1.75859540
24IKBKB1.67717370
25CDK191.66401996
26TXK1.66201679
27ZAP701.61794865
28* CSF1R1.60627951
29STK161.53438594
30IKBKE1.51099287
31MATK1.45166048
32FES1.44514468
33MAP2K31.43826296
34SCYL21.43419532
35BLK1.40127235
36ERN11.38660044
37RIPK41.37463934
38NLK1.30950324
39TAOK31.29790624
40CDK61.28184975
41VRK11.27838954
42BRSK11.26332711
43TRPM71.24911594
44MAP3K131.23666073
45PIM21.23607452
46NUAK11.21785649
47MAPKAPK31.18758040
48CAMKK21.14070913
49MAP3K121.13404110
50CDK121.13002203
51CLK11.12541231
52LYN1.09322306
53VRK21.08244637
54CDK81.00760657
55* LCK0.98225156
56DYRK30.97016641
57SIK30.94569505
58RPS6KB20.91587479
59MUSK0.89921054
60JAK20.86350041
61BMPR1B0.84981828
62CHUK0.82663708
63PRKCQ0.80971037
64PASK0.79075145
65RPS6KC10.78018420
66RPS6KL10.78018420
67PIM10.77164208
68MAP3K100.76562342
69BCKDK0.75010090
70MAP3K10.74732742
71GRK60.74587975
72ITK0.74079402
73TESK20.74042101
74BRD40.73957744
75LRRK20.73721747
76RIPK10.71671824
77BUB10.70996887
78MAP2K20.68912182
79ATR0.68721399
80HCK0.68517442
81TSSK60.66187686
82MAP4K20.64568653
83MKNK10.64065289
84MAP2K60.63971886
85MAPK120.63649808
86MAPKAPK50.62730564
87TAOK20.62465683
88PRKAA20.60091609
89CDC70.57458077
90MAP3K60.57199603
91MAPK40.57009362
92HIPK20.56409223
93PIK3CA0.56194408
94CAMK10.54489519
95DAPK10.53347720
96CDK90.51541754
97PDK10.51282032
98TLK10.50658572
99MAPK70.50234184
100FRK0.49329124
101GRK70.47004285
102ABL10.45969368
103YES10.45299442
104NEK20.45229791
105PRKD20.45172169
106CDK70.44991090
107STK40.44374625
108RPS6KA40.43194483
109JAK10.41741147
110DYRK1B0.41127440
111EIF2AK30.39363431
112MAP3K50.39207688
113RPS6KA60.38921554
114CDK40.38854597
115CDK30.37508028
116TAF10.37388259
117MAPK110.36771259
118CAMKK10.36509539
119MAPK150.36237834
120CDK20.35838786
121KDR0.35213190
122SIK20.34820274
123PRKG20.34669047
124IRAK30.34459233
125RPS6KA10.34329143
126MAPKAPK20.33513752
127PRKCH0.32789020
128PINK10.32612246
129MAP3K70.32195989
130AKT20.32148085
131PAK20.31758706
132MAP3K110.30770295
133MKNK20.30142627
134MARK30.30070669
135MAPK30.29690694
136STK100.27976293
137MAP2K70.27594793

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.68499440
2DNA replication_Homo sapiens_hsa030304.23367295
3Ribosome_Homo sapiens_hsa030103.54139098
4Mismatch repair_Homo sapiens_hsa034303.27922290
5Autoimmune thyroid disease_Homo sapiens_hsa053203.27379425
6Graft-versus-host disease_Homo sapiens_hsa053323.26871392
7Primary immunodeficiency_Homo sapiens_hsa053403.04811939
8Non-homologous end-joining_Homo sapiens_hsa034502.75521215
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56643311
10Base excision repair_Homo sapiens_hsa034102.49882296
11Homologous recombination_Homo sapiens_hsa034402.39424973
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.35257395
13Staphylococcus aureus infection_Homo sapiens_hsa051502.29251793
14B cell receptor signaling pathway_Homo sapiens_hsa046622.27993566
15Leishmaniasis_Homo sapiens_hsa051402.27798746
16Antigen processing and presentation_Homo sapiens_hsa046122.09818098
17Allograft rejection_Homo sapiens_hsa053302.02427093
18Herpes simplex infection_Homo sapiens_hsa051681.98173187
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.92969121
20Measles_Homo sapiens_hsa051621.89247298
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86942276
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86769650
23Nucleotide excision repair_Homo sapiens_hsa034201.79052347
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74597754
25Pyrimidine metabolism_Homo sapiens_hsa002401.66657189
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.60861801
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59657294
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.54693808
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54553796
30Legionellosis_Homo sapiens_hsa051341.53264274
31Rheumatoid arthritis_Homo sapiens_hsa053231.53042065
32Spliceosome_Homo sapiens_hsa030401.51334456
33Osteoclast differentiation_Homo sapiens_hsa043801.49233496
34* Hematopoietic cell lineage_Homo sapiens_hsa046401.41425697
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31454273
36RNA polymerase_Homo sapiens_hsa030201.31084527
37Influenza A_Homo sapiens_hsa051641.30952897
38* Acute myeloid leukemia_Homo sapiens_hsa052211.29670582
39* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22960344
40Toxoplasmosis_Homo sapiens_hsa051451.22460204
41Pertussis_Homo sapiens_hsa051331.21077006
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15306865
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12539308
44Shigellosis_Homo sapiens_hsa051311.12353407
45Fanconi anemia pathway_Homo sapiens_hsa034601.12348175
46RNA degradation_Homo sapiens_hsa030181.12091116
47Cell cycle_Homo sapiens_hsa041101.09471632
48African trypanosomiasis_Homo sapiens_hsa051431.06596163
49Type I diabetes mellitus_Homo sapiens_hsa049401.05829607
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04036386
51Epstein-Barr virus infection_Homo sapiens_hsa051691.01064528
52Apoptosis_Homo sapiens_hsa042100.98854184
53Tuberculosis_Homo sapiens_hsa051520.96128246
54N-Glycan biosynthesis_Homo sapiens_hsa005100.91799194
55p53 signaling pathway_Homo sapiens_hsa041150.90425617
56Hepatitis B_Homo sapiens_hsa051610.88352585
57Platelet activation_Homo sapiens_hsa046110.87164578
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86413320
59Purine metabolism_Homo sapiens_hsa002300.84946748
60Malaria_Homo sapiens_hsa051440.82565098
61Pentose phosphate pathway_Homo sapiens_hsa000300.79858322
62* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77611803
63T cell receptor signaling pathway_Homo sapiens_hsa046600.76967881
64TNF signaling pathway_Homo sapiens_hsa046680.76865390
65Proteasome_Homo sapiens_hsa030500.75885437
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75826136
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72618944
68Protein export_Homo sapiens_hsa030600.72384055
69Chemokine signaling pathway_Homo sapiens_hsa040620.71375753
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70654208
71Viral carcinogenesis_Homo sapiens_hsa052030.69006134
72Folate biosynthesis_Homo sapiens_hsa007900.67449130
73Other glycan degradation_Homo sapiens_hsa005110.66653276
74One carbon pool by folate_Homo sapiens_hsa006700.66614486
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.63645415
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63121547
77Thyroid cancer_Homo sapiens_hsa052160.61947215
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61285523
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.59318912
80Chronic myeloid leukemia_Homo sapiens_hsa052200.58200933
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.57864258
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.54999361
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.54886283
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54239635
85Hepatitis C_Homo sapiens_hsa051600.52904152
86Non-small cell lung cancer_Homo sapiens_hsa052230.51702261
87Small cell lung cancer_Homo sapiens_hsa052220.51435821
88Basal transcription factors_Homo sapiens_hsa030220.48467372
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46510408
90HTLV-I infection_Homo sapiens_hsa051660.45885283
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45238088
92Salmonella infection_Homo sapiens_hsa051320.45138255
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44921016
94Regulation of autophagy_Homo sapiens_hsa041400.44856553
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.44457584
96Systemic lupus erythematosus_Homo sapiens_hsa053220.43821385
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43545855
98Renin-angiotensin system_Homo sapiens_hsa046140.43315701
99Salivary secretion_Homo sapiens_hsa049700.43311142
100Phagosome_Homo sapiens_hsa041450.42681080
101Ether lipid metabolism_Homo sapiens_hsa005650.42325148
102Arachidonic acid metabolism_Homo sapiens_hsa005900.41075092
103Colorectal cancer_Homo sapiens_hsa052100.40445830
104Pancreatic cancer_Homo sapiens_hsa052120.39929895
105Lysosome_Homo sapiens_hsa041420.38873338
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37282389
107Olfactory transduction_Homo sapiens_hsa047400.36855703
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35745680
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34799480
110Caffeine metabolism_Homo sapiens_hsa002320.34782771
111RNA transport_Homo sapiens_hsa030130.34779747
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34370381
113Peroxisome_Homo sapiens_hsa041460.33748912
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32188721
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31177941
116Selenocompound metabolism_Homo sapiens_hsa004500.29874206
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.28030357
118Viral myocarditis_Homo sapiens_hsa054160.27171189
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26761141
120Dorso-ventral axis formation_Homo sapiens_hsa043200.26337044
121VEGF signaling pathway_Homo sapiens_hsa043700.26220911
122Prolactin signaling pathway_Homo sapiens_hsa049170.25949146
123Renin secretion_Homo sapiens_hsa049240.24947820
124Linoleic acid metabolism_Homo sapiens_hsa005910.24770178
125mRNA surveillance pathway_Homo sapiens_hsa030150.24288268
126Pancreatic secretion_Homo sapiens_hsa049720.24074629
127mTOR signaling pathway_Homo sapiens_hsa041500.24022026
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21583612
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21100879

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