FLT3LG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.09818866
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.09818866
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.07842621
4negative T cell selection (GO:0043383)5.85397527
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.73522588
6antigen processing and presentation of endogenous antigen (GO:0019883)5.58219521
7negative thymic T cell selection (GO:0045060)5.51802144
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.51348208
9positive regulation of gamma-delta T cell activation (GO:0046645)5.29111091
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.22118410
11activated T cell proliferation (GO:0050798)5.01909558
12tolerance induction (GO:0002507)4.96775213
13DNA deamination (GO:0045006)4.92994404
14cellular response to interleukin-15 (GO:0071350)4.86537965
15response to interleukin-15 (GO:0070672)4.79818198
16regulation of B cell receptor signaling pathway (GO:0050855)4.69528958
17cytidine deamination (GO:0009972)4.62963045
18cytidine metabolic process (GO:0046087)4.62963045
19cytidine catabolic process (GO:0006216)4.62963045
20positive T cell selection (GO:0043368)4.58784390
21pyrimidine ribonucleoside catabolic process (GO:0046133)4.49459529
22leukocyte aggregation (GO:0070486)4.33464346
23regulation of gamma-delta T cell differentiation (GO:0045586)4.30427723
24positive thymic T cell selection (GO:0045059)4.29895367
25thymic T cell selection (GO:0045061)4.21447595
26T cell selection (GO:0045058)4.20752787
27positive regulation of T cell mediated cytotoxicity (GO:0001916)4.16602697
28regulation of gamma-delta T cell activation (GO:0046643)4.15433689
29regulation of T cell mediated cytotoxicity (GO:0001914)4.14790361
30regulation of regulatory T cell differentiation (GO:0045589)4.11900489
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.07829931
32regulation of T cell tolerance induction (GO:0002664)4.05532485
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.88365843
34regulation of alpha-beta T cell proliferation (GO:0046640)3.86053046
35antigen processing and presentation via MHC class Ib (GO:0002475)3.85741805
36regulation of natural killer cell mediated immunity (GO:0002715)3.76745052
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.76745052
38negative regulation of T cell mediated immunity (GO:0002710)3.76218324
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.75436369
40regulation of leukocyte mediated cytotoxicity (GO:0001910)3.67821327
41T cell migration (GO:0072678)3.62960020
42regulation of isotype switching to IgG isotypes (GO:0048302)3.62949098
43positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.62071086
44positive regulation of tolerance induction (GO:0002645)3.61735304
45mast cell activation (GO:0045576)3.48351248
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.46555439
47interferon-gamma production (GO:0032609)3.43475216
48positive regulation of defense response to virus by host (GO:0002230)3.41694112
49T cell receptor signaling pathway (GO:0050852)3.41201719
50regulation of tolerance induction (GO:0002643)3.39318377
51positive regulation of alpha-beta T cell proliferation (GO:0046641)3.38085535
52positive regulation of granulocyte differentiation (GO:0030854)3.36648950
53regulation of cell killing (GO:0031341)3.34347050
54negative regulation of interleukin-1 beta production (GO:0032691)3.30743223
55antigen receptor-mediated signaling pathway (GO:0050851)3.28795487
56regulation of B cell differentiation (GO:0045577)3.27372571
57positive regulation of cell killing (GO:0031343)3.26705134
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.25566755
59positive regulation of antigen processing and presentation (GO:0002579)3.22185089
60negative regulation of leukocyte mediated immunity (GO:0002704)3.19325547
61positive regulation of calcium-mediated signaling (GO:0050850)3.15552093
62negative regulation of interleukin-1 production (GO:0032692)3.13753760
63mast cell activation involved in immune response (GO:0002279)3.10798124
64mast cell degranulation (GO:0043303)3.10798124
65negative regulation of phagocytosis (GO:0050765)3.08832866
66regulation of memory T cell differentiation (GO:0043380)3.04616995
67positive regulation of natural killer cell mediated immunity (GO:0002717)3.04353051
68positive regulation of T cell differentiation in thymus (GO:0033089)3.04079057
69alpha-beta T cell differentiation (GO:0046632)2.95082145
70regulation of interleukin-2 biosynthetic process (GO:0045076)2.95004080
71regulation of T cell mediated immunity (GO:0002709)2.92979489
72positive regulation of B cell differentiation (GO:0045579)2.92467417
73positive regulation of T cell mediated immunity (GO:0002711)2.89256231
74T cell homeostasis (GO:0043029)2.88734365
75regulation of antigen processing and presentation (GO:0002577)2.87198856
76response to type I interferon (GO:0034340)2.85292246
77negative regulation of interleukin-12 production (GO:0032695)2.85001290
78regulation of T cell receptor signaling pathway (GO:0050856)2.84660892
79response to interferon-beta (GO:0035456)2.82410775
80type I interferon signaling pathway (GO:0060337)2.81772055
81cellular response to type I interferon (GO:0071357)2.81772055
82regulation of alpha-beta T cell activation (GO:0046634)2.81138075
83leukocyte degranulation (GO:0043299)2.77606678
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.76630269
85negative regulation of innate immune response (GO:0045824)2.76478807
86dendritic cell chemotaxis (GO:0002407)2.76223491
87B cell receptor signaling pathway (GO:0050853)2.74962060
88T cell differentiation (GO:0030217)2.72980551
89negative regulation of interleukin-6 production (GO:0032715)2.68925604
90positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.68331294
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.67926859
92immunoglobulin mediated immune response (GO:0016064)2.67110391
93dendritic cell migration (GO:0036336)2.65910732
94alpha-beta T cell activation (GO:0046631)2.65178917
95Peyers patch development (GO:0048541)2.64587160
96mucosal-associated lymphoid tissue development (GO:0048537)2.64587160
97neutrophil activation (GO:0042119)2.64563141
98T cell costimulation (GO:0031295)2.63307798
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.63275106
100positive regulation of lymphocyte mediated immunity (GO:0002708)2.62449378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.63934669
2* IRF8_22096565_ChIP-ChIP_GC-B_Human5.38537144
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.10863615
4RUNX_20019798_ChIP-Seq_JUKART_Human3.52342127
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.36352348
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.86904403
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76857021
8MYB_26560356_Chip-Seq_TH2_Human2.76339111
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.66635399
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.63485851
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26763026
12ZNF274_21170338_ChIP-Seq_K562_Hela2.26327698
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21595833
14* GATA3_26560356_Chip-Seq_TH2_Human2.13524524
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12235562
16GATA3_27048872_Chip-Seq_THYMUS_Human2.10817193
17MYB_26560356_Chip-Seq_TH1_Human2.08672814
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07862860
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05568530
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03198381
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02260643
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00730982
23* UTX_26944678_Chip-Seq_JUKART_Human1.96276245
24MAF_26560356_Chip-Seq_TH1_Human1.90228939
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87616831
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85067141
27* MAF_26560356_Chip-Seq_TH2_Human1.76724797
28EZH2_22144423_ChIP-Seq_EOC_Human1.71113585
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59857860
30SPI1_23547873_ChIP-Seq_NB4_Human1.56240212
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.52372155
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46665774
33VDR_22108803_ChIP-Seq_LS180_Human1.45733105
34BCL6_27268052_Chip-Seq_Bcells_Human1.44530082
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41635939
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41196035
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39117795
38* VDR_23849224_ChIP-Seq_CD4+_Human1.36030619
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35148264
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32240095
41VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.31450717
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29533587
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28470122
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28039085
45GATA1_22025678_ChIP-Seq_K562_Human1.27684473
46RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27560253
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.25502194
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22746874
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22186362
50NANOG_20526341_ChIP-Seq_ESCs_Human1.21727540
51SCL_19346495_ChIP-Seq_HPC-7_Human1.19664864
52ERA_21632823_ChIP-Seq_H3396_Human1.18922488
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17892646
54TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17299024
55SPI1_23127762_ChIP-Seq_K562_Human1.16735262
56FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12283844
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11253197
58* GATA3_21878914_ChIP-Seq_MCF-7_Human1.09901993
59P300_27268052_Chip-Seq_Bcells_Human1.08053047
60BCOR_27268052_Chip-Seq_Bcells_Human1.07797437
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07790077
62TP53_22573176_ChIP-Seq_HFKS_Human1.04479263
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.04175101
64TAF2_19829295_ChIP-Seq_ESCs_Human1.04071094
65CIITA_25753668_ChIP-Seq_RAJI_Human1.03031925
66VDR_24763502_ChIP-Seq_THP-1_Human1.02932447
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02660006
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02418064
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.01997202
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00175147
71ELF1_20517297_ChIP-Seq_JURKAT_Human0.99637569
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99223153
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96255428
74ER_23166858_ChIP-Seq_MCF-7_Human0.95656140
75MYC_22102868_ChIP-Seq_BL_Human0.94323550
76VDR_21846776_ChIP-Seq_THP-1_Human0.94303330
77E2F1_20622854_ChIP-Seq_HELA_Human0.93877929
78GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93791978
79SMRT_27268052_Chip-Seq_Bcells_Human0.93735482
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93170186
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.93170186
82FOXP3_21729870_ChIP-Seq_TREG_Human0.92531236
83GATA3_26560356_Chip-Seq_TH1_Human0.92187283
84ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92045557
85SPI1_20517297_ChIP-Seq_HL60_Human0.90029116
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89839651
87MYC_19829295_ChIP-Seq_ESCs_Human0.89019650
88RAC3_21632823_ChIP-Seq_H3396_Human0.88697124
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86970918
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85299259
91DROSHA_22980978_ChIP-Seq_HELA_Human0.84308693
92PHF8_20622854_ChIP-Seq_HELA_Human0.84205124
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.83894219
94OCT4_20526341_ChIP-Seq_ESCs_Human0.82840521
95BCAT_22108803_ChIP-Seq_LS180_Human0.82795175
96VDR_24787735_ChIP-Seq_THP-1_Human0.82669156
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82335825
98NCOR_22424771_ChIP-Seq_293T_Human0.81634119
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81258307
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.80347462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.32901640
2MP0003724_increased_susceptibility_to3.55891088
3MP0003763_abnormal_thymus_physiology3.54707033
4MP0003436_decreased_susceptibility_to3.42055900
5MP0001835_abnormal_antigen_presentation3.19785511
6MP0001800_abnormal_humoral_immune3.17656858
7MP0000685_abnormal_immune_system3.13509764
8MP0005000_abnormal_immune_tolerance2.86877314
9MP0001790_abnormal_immune_system2.84924559
10MP0005387_immune_system_phenotype2.84924559
11MP0009785_altered_susceptibility_to2.64098449
12MP0002723_abnormal_immune_serum2.62378604
13MP0002420_abnormal_adaptive_immunity2.54180202
14MP0001819_abnormal_immune_cell2.50204676
15MP0005025_abnormal_response_to2.42590775
16MP0002452_abnormal_antigen_presenting2.35742495
17MP0001873_stomach_inflammation2.27182568
18MP0009333_abnormal_splenocyte_physiolog2.24595810
19MP0002148_abnormal_hypersensitivity_rea2.17132270
20MP0002419_abnormal_innate_immunity2.06423251
21MP0002405_respiratory_system_inflammati2.05661755
22MP0002398_abnormal_bone_marrow1.97162844
23MP0000716_abnormal_immune_system1.95543164
24MP0003866_abnormal_defecation1.95053771
25MP0006082_CNS_inflammation1.92735582
26MP0000703_abnormal_thymus_morphology1.84676655
27MP0002933_joint_inflammation1.81914165
28MP0002277_abnormal_respiratory_mucosa1.79709524
29MP0005075_abnormal_melanosome_morpholog1.76539782
30MP0010155_abnormal_intestine_physiology1.73639369
31MP0000689_abnormal_spleen_morphology1.73209047
32MP0001533_abnormal_skeleton_physiology1.71564480
33MP0003646_muscle_fatigue1.69696590
34MP0002138_abnormal_hepatobiliary_system1.66976843
35MP0002722_abnormal_immune_system1.58711960
36MP0001845_abnormal_inflammatory_respons1.57203169
37MP0001986_abnormal_taste_sensitivity1.52613232
38MP0002429_abnormal_blood_cell1.46236018
39MP0009764_decreased_sensitivity_to1.41539161
40MP0004381_abnormal_hair_follicle1.40584305
41MP0002102_abnormal_ear_morphology1.38449386
42MP0001501_abnormal_sleep_pattern1.30165837
43MP0004147_increased_porphyrin_level1.24594348
44MP0004947_skin_inflammation1.24188415
45MP0005377_hearing/vestibular/ear_phenot1.23959565
46MP0003878_abnormal_ear_physiology1.23959565
47MP0001348_abnormal_lacrimal_gland1.23880094
48MP0002132_abnormal_respiratory_system1.21726723
49MP0008872_abnormal_physiological_respon1.20476112
50MP0000465_gastrointestinal_hemorrhage1.18698144
51MP0005310_abnormal_salivary_gland1.17752218
52MP0004130_abnormal_muscle_cell1.16761917
53MP0008877_abnormal_DNA_methylation1.15205003
54MP0008469_abnormal_protein_level1.14600938
55MP0002166_altered_tumor_susceptibility1.13281486
56MP0004142_abnormal_muscle_tone1.13135120
57MP0000372_irregular_coat_pigmentation0.99084670
58MP0001663_abnormal_digestive_system0.97753694
59MP0001968_abnormal_touch/_nociception0.97289916
60MP0005645_abnormal_hypothalamus_physiol0.96836919
61MP0005167_abnormal_blood-brain_barrier0.96290357
62MP0001851_eye_inflammation0.94206208
63MP0005464_abnormal_platelet_physiology0.93764947
64MP0003011_delayed_dark_adaptation0.92841767
65MP0003300_gastrointestinal_ulcer0.92722510
66MP0002693_abnormal_pancreas_physiology0.92359542
67MP0001919_abnormal_reproductive_system0.92190810
68MP0003787_abnormal_imprinting0.86901106
69MP0005551_abnormal_eye_electrophysiolog0.86036488
70MP0008961_abnormal_basal_metabolism0.83017483
71MP0002163_abnormal_gland_morphology0.82224704
72MP0002638_abnormal_pupillary_reflex0.81926177
73MP0003303_peritoneal_inflammation0.81650872
74MP0005174_abnormal_tail_pigmentation0.81381739
75MP0003195_calcinosis0.79430784
76MP0002928_abnormal_bile_duct0.78554022
77MP0002006_tumorigenesis0.78101619
78MP0004043_abnormal_pH_regulation0.76405375
79MP0002876_abnormal_thyroid_physiology0.75545698
80MP0000015_abnormal_ear_pigmentation0.74138395
81MP0004742_abnormal_vestibular_system0.73778176
82MP0009745_abnormal_behavioral_response0.73242707
83MP0005084_abnormal_gallbladder_morpholo0.72789181
84MP0003638_abnormal_response/metabolism_0.72270672
85MP0004885_abnormal_endolymph0.67735969
86MP0005390_skeleton_phenotype0.67158414
87MP0002837_dystrophic_cardiac_calcinosis0.66418836
88MP0000569_abnormal_digit_pigmentation0.65432273
89MP0002009_preneoplasia0.65337782
90MP0002653_abnormal_ependyma_morphology0.64776198
91MP0009765_abnormal_xenobiotic_induced0.64359823
92MP0003045_fibrosis0.64008579
93MP0008875_abnormal_xenobiotic_pharmacok0.63418137
94MP0009763_increased_sensitivity_to0.60849378
95MP0005389_reproductive_system_phenotype0.60677313
96MP0006072_abnormal_retinal_apoptosis0.60624275
97MP0004883_abnormal_blood_vessel0.59437153
98MP0002396_abnormal_hematopoietic_system0.59060300
99MP0005253_abnormal_eye_physiology0.57299941
100MP0002095_abnormal_skin_pigmentation0.56766829

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.53679134
2Elevated erythrocyte sedimentation rate (HP:0003565)5.20042782
3Myositis (HP:0100614)4.38013410
4T lymphocytopenia (HP:0005403)4.31312734
5Abnormality of T cell number (HP:0011839)4.15368624
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.11964687
7IgG deficiency (HP:0004315)4.00868820
8Panhypogammaglobulinemia (HP:0003139)3.90320809
9Optic neuritis (HP:0100653)3.88634707
10Retrobulbar optic neuritis (HP:0100654)3.88634707
11Abnormality of T cells (HP:0002843)3.82801709
12Severe combined immunodeficiency (HP:0004430)3.78486086
13Pustule (HP:0200039)3.74813635
14Orchitis (HP:0100796)3.65727558
15Congenital stationary night blindness (HP:0007642)3.56972327
16Eczematoid dermatitis (HP:0000976)3.55207392
17Recurrent fungal infections (HP:0002841)3.53771366
18Encephalitis (HP:0002383)3.51406527
19Abnormality of T cell physiology (HP:0011840)3.13650525
20Increased IgM level (HP:0003496)3.12134027
21Recurrent cutaneous fungal infections (HP:0011370)3.10748808
22Chronic mucocutaneous candidiasis (HP:0002728)3.10748808
23Abnormality of eosinophils (HP:0001879)2.97048231
24Meningitis (HP:0001287)2.88301031
25Pancreatic cysts (HP:0001737)2.85851352
26Recurrent bacterial skin infections (HP:0005406)2.83418019
27Gastrointestinal infarctions (HP:0005244)2.82649364
28Hypochromic microcytic anemia (HP:0004840)2.79710864
29Hypochromic anemia (HP:0001931)2.78856774
30Recurrent abscess formation (HP:0002722)2.76380686
31Leukocytosis (HP:0001974)2.74661868
32Keratoconjunctivitis (HP:0001096)2.70048867
33Eosinophilia (HP:0001880)2.68969736
34Combined immunodeficiency (HP:0005387)2.66727161
35Abnormality of macrophages (HP:0004311)2.66664225
36Pulmonary infiltrates (HP:0002113)2.63819411
37Vasculitis (HP:0002633)2.62628531
38Autoimmune hemolytic anemia (HP:0001890)2.62051688
39Keratoconjunctivitis sicca (HP:0001097)2.56123065
40Granulocytopenia (HP:0001913)2.52705301
41Molar tooth sign on MRI (HP:0002419)2.49323733
42Abnormality of midbrain morphology (HP:0002418)2.49323733
43Thyroiditis (HP:0100646)2.48422578
44Abnormal rod and cone electroretinograms (HP:0008323)2.46077101
45Stomach cancer (HP:0012126)2.45670117
46Lymphopenia (HP:0001888)2.44709616
47Recurrent skin infections (HP:0001581)2.42535425
48Recurrent bronchitis (HP:0002837)2.40176592
49Mediastinal lymphadenopathy (HP:0100721)2.37993731
50Abnormality of the renal cortex (HP:0011035)2.35786522
51Hemoptysis (HP:0002105)2.35378044
52Attenuation of retinal blood vessels (HP:0007843)2.32638734
53Abnormality of B cell number (HP:0010975)2.31997014
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28853106
55Recurrent viral infections (HP:0004429)2.23695802
56Chronic obstructive pulmonary disease (HP:0006510)2.22561694
57Obstructive lung disease (HP:0006536)2.22561694
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21704690
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.20182613
60Type II lissencephaly (HP:0007260)2.16989638
61Birth length less than 3rd percentile (HP:0003561)2.16185491
623-Methylglutaconic aciduria (HP:0003535)2.14981380
63Pancreatic fibrosis (HP:0100732)2.13866574
64Agammaglobulinemia (HP:0004432)2.11002730
65IgM deficiency (HP:0002850)2.10537206
66Increased IgE level (HP:0003212)2.07908649
67Nephronophthisis (HP:0000090)2.03836820
68Chronic diarrhea (HP:0002028)2.03180616
69Hyperventilation (HP:0002883)2.02194493
70Hypoproteinemia (HP:0003075)2.00030565
71Aplastic anemia (HP:0001915)1.98642490
72True hermaphroditism (HP:0010459)1.98005174
73Spontaneous hematomas (HP:0007420)1.96698525
74Inability to walk (HP:0002540)1.96403487
75Chronic otitis media (HP:0000389)1.95760503
76Inflammation of the large intestine (HP:0002037)1.94746388
77Chronic sinusitis (HP:0011109)1.94247340
78B lymphocytopenia (HP:0010976)1.92844866
79Chest pain (HP:0100749)1.92692617
80Autoimmune thrombocytopenia (HP:0001973)1.92571893
81Microcytic anemia (HP:0001935)1.91799315
82Anorexia (HP:0002039)1.91562956
83Verrucae (HP:0200043)1.90115830
84Papilloma (HP:0012740)1.90115830
85Prolonged bleeding time (HP:0003010)1.89786572
86Hemiplegia (HP:0002301)1.88148470
87Abolished electroretinogram (ERG) (HP:0000550)1.87724943
88Clumsiness (HP:0002312)1.87344240
89Abnormal drinking behavior (HP:0030082)1.87341942
90Polydipsia (HP:0001959)1.87341942
91Hypergammaglobulinemia (HP:0010702)1.86889726
92Papilledema (HP:0001085)1.86824774
93Joint swelling (HP:0001386)1.85564793
94Abnormality of the pleura (HP:0002103)1.84517208
95Keratitis (HP:0000491)1.83612012
96Recurrent gram-negative bacterial infections (HP:0005420)1.82523365
97Pulmonary embolism (HP:0002204)1.81730139
98Microretrognathia (HP:0000308)1.80887419
99Abnormality of the renal medulla (HP:0100957)1.79323384
100Episodic fever (HP:0001954)1.78911944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.61193456
2TXK4.53168817
3TAOK34.39308227
4GRK62.52739366
5FES2.37751275
6ITK2.28166854
7TNK22.19871680
8ADRBK22.19157879
9RIPK42.16265091
10CAMKK22.15899354
11ACVR1B2.11308211
12ZAP701.95885695
13FRK1.93339188
14IKBKE1.91134877
15SYK1.84590519
16BTK1.83276425
17SIK21.79782480
18TLK11.76986814
19TYK21.71531780
20JAK31.68718118
21CAMKK11.67972519
22LCK1.65803802
23CSK1.64593535
24IRAK41.63951469
25BMPR1B1.57059670
26KDR1.54207037
27IKBKB1.47123619
28GRK11.42715260
29TEC1.40544644
30DAPK21.34056078
31HCK1.32660946
32LYN1.32338322
33PRKCQ1.29524294
34ZAK1.25392737
35KIT1.24142685
36TESK21.18939311
37PASK1.18193345
38NLK1.17915619
39MARK31.16894001
40SIK31.11071268
41BLK1.10305735
42TBK11.08458340
43MAP4K21.06904102
44WNK41.05187952
45MAPK131.03175507
46MAP3K110.96495179
47PTK2B0.95443051
48JAK10.92349164
49MAP2K60.90828117
50MAP2K20.90489870
51NUAK10.88896554
52ADRBK10.87111685
53MAP3K140.84252852
54PINK10.80457758
55TGFBR10.75580776
56EPHB10.75521386
57CSF1R0.74242130
58MAP3K70.73701532
59NTRK20.72907416
60HIPK20.72777991
61MAP2K30.69068959
62PIM10.68828014
63MAPK150.68754222
64PRKCH0.65854592
65INSRR0.65631541
66GRK70.65242824
67JAK20.61664129
68WNK30.61045790
69PRKD20.60435262
70BCKDK0.60188261
71FGR0.59420669
72STK110.57163690
73MAPK120.57036226
74RPS6KA60.56489189
75MAP3K130.52112096
76ERN10.52004176
77PDK10.49286122
78CDK190.47857422
79CAMK40.44067576
80TYRO30.43798724
81OXSR10.43702168
82IRAK10.42463977
83CHUK0.42205224
84MAPK70.41692628
85MAPK110.40398161
86STK380.39303588
87TAOK10.39102602
88RPS6KA50.39050703
89FYN0.38826424
90MELK0.36414264
91CASK0.35883762
92CAMK10.34945696
93STK100.31849816
94PAK30.28633250
95CDK40.27233410
96EPHA30.26138109
97MAPKAPK30.25905472
98CDC42BPA0.25857610
99PRKCZ0.24666430
100ABL10.24363873

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.27875970
2Allograft rejection_Homo sapiens_hsa053303.28815913
3Graft-versus-host disease_Homo sapiens_hsa053323.26155626
4Autoimmune thyroid disease_Homo sapiens_hsa053203.21373259
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.82179228
6T cell receptor signaling pathway_Homo sapiens_hsa046602.79962451
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.60371368
8Type I diabetes mellitus_Homo sapiens_hsa049402.49039377
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.45675936
10Antigen processing and presentation_Homo sapiens_hsa046122.20304209
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.02413015
12* Hematopoietic cell lineage_Homo sapiens_hsa046402.00355783
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96510755
14Asthma_Homo sapiens_hsa053101.80580944
15Measles_Homo sapiens_hsa051621.77038265
16Osteoclast differentiation_Homo sapiens_hsa043801.76320799
17Leishmaniasis_Homo sapiens_hsa051401.57563605
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57503083
19Staphylococcus aureus infection_Homo sapiens_hsa051501.53194779
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51256152
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50480884
22Linoleic acid metabolism_Homo sapiens_hsa005911.48757386
23B cell receptor signaling pathway_Homo sapiens_hsa046621.45001375
24* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44607428
25Viral myocarditis_Homo sapiens_hsa054161.41994185
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.36650908
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35295769
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31917021
29Nitrogen metabolism_Homo sapiens_hsa009101.26258535
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24132624
31Rheumatoid arthritis_Homo sapiens_hsa053231.22153650
32Malaria_Homo sapiens_hsa051441.22106638
33Phototransduction_Homo sapiens_hsa047441.21618385
34Chemokine signaling pathway_Homo sapiens_hsa040621.17225468
35Herpes simplex infection_Homo sapiens_hsa051681.16376209
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12998766
37Regulation of autophagy_Homo sapiens_hsa041401.10307620
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09984964
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04236447
40Oxidative phosphorylation_Homo sapiens_hsa001901.00820670
41Tuberculosis_Homo sapiens_hsa051521.00134051
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95801191
43TNF signaling pathway_Homo sapiens_hsa046680.93386913
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92291192
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89895528
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89891017
47African trypanosomiasis_Homo sapiens_hsa051430.85267486
48Ether lipid metabolism_Homo sapiens_hsa005650.81504099
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80204746
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80088307
51ABC transporters_Homo sapiens_hsa020100.76134869
52Ribosome_Homo sapiens_hsa030100.73333411
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73061032
54Morphine addiction_Homo sapiens_hsa050320.71007759
55Arachidonic acid metabolism_Homo sapiens_hsa005900.68346092
56Parkinsons disease_Homo sapiens_hsa050120.66847038
57Toxoplasmosis_Homo sapiens_hsa051450.66339829
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64314417
59Influenza A_Homo sapiens_hsa051640.64262445
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.63523734
61Platelet activation_Homo sapiens_hsa046110.59236216
62Acute myeloid leukemia_Homo sapiens_hsa052210.57497946
63Epstein-Barr virus infection_Homo sapiens_hsa051690.56031225
64Collecting duct acid secretion_Homo sapiens_hsa049660.54129680
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53451793
66MAPK signaling pathway_Homo sapiens_hsa040100.53193878
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.52930423
68Dorso-ventral axis formation_Homo sapiens_hsa043200.51855270
69Glycerolipid metabolism_Homo sapiens_hsa005610.50911177
70RNA polymerase_Homo sapiens_hsa030200.50779554
71Olfactory transduction_Homo sapiens_hsa047400.49500487
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47658704
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44447196
74Legionellosis_Homo sapiens_hsa051340.43938763
75RNA degradation_Homo sapiens_hsa030180.43241563
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41864330
77Apoptosis_Homo sapiens_hsa042100.38917606
78Caffeine metabolism_Homo sapiens_hsa002320.38754937
79Hepatitis B_Homo sapiens_hsa051610.37347147
80Alzheimers disease_Homo sapiens_hsa050100.36972933
81HTLV-I infection_Homo sapiens_hsa051660.36712416
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36457045
83Proteasome_Homo sapiens_hsa030500.33386442
84Serotonergic synapse_Homo sapiens_hsa047260.32233132
85Phagosome_Homo sapiens_hsa041450.32226841
86Calcium signaling pathway_Homo sapiens_hsa040200.31488901
87Butanoate metabolism_Homo sapiens_hsa006500.31146177
88Shigellosis_Homo sapiens_hsa051310.29493055
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.29115125
90Pertussis_Homo sapiens_hsa051330.28849663
91Ras signaling pathway_Homo sapiens_hsa040140.28056033
92Nicotine addiction_Homo sapiens_hsa050330.27242634
93Hepatitis C_Homo sapiens_hsa051600.26805756
94Ovarian steroidogenesis_Homo sapiens_hsa049130.26681575
95Homologous recombination_Homo sapiens_hsa034400.26637884
96VEGF signaling pathway_Homo sapiens_hsa043700.26265163
97FoxO signaling pathway_Homo sapiens_hsa040680.25056646
98Taste transduction_Homo sapiens_hsa047420.23361355
99Chemical carcinogenesis_Homo sapiens_hsa052040.23133593
100Oxytocin signaling pathway_Homo sapiens_hsa049210.23117045

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