FLVCR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)4.79259509
2response to peptidoglycan (GO:0032494)4.64028238
3regulation of vitamin D biosynthetic process (GO:0060556)4.29917751
4glycosphingolipid catabolic process (GO:0046479)4.13616823
5regulation of mononuclear cell migration (GO:0071675)3.99339234
6macrophage activation involved in immune response (GO:0002281)3.92858597
7lipopolysaccharide-mediated signaling pathway (GO:0031663)3.92075567
8regulation of vitamin metabolic process (GO:0030656)3.84413417
9neutrophil activation involved in immune response (GO:0002283)3.83669482
10regulation of cytokine secretion involved in immune response (GO:0002739)3.83223759
11oligosaccharide catabolic process (GO:0009313)3.74309960
12glycolipid catabolic process (GO:0019377)3.72386125
13immunoglobulin mediated immune response (GO:0016064)3.71866423
14regulation of podosome assembly (GO:0071801)3.61789218
15T-helper 1 type immune response (GO:0042088)3.61735228
16cellular response to thyroid hormone stimulus (GO:0097067)3.61528827
17positive regulation of gamma-delta T cell activation (GO:0046645)3.46065756
18positive regulation of chemokine biosynthetic process (GO:0045080)3.44420724
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43846219
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43846219
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.43846219
22modulation by symbiont of host immune response (GO:0052553)3.43846219
23positive regulation by symbiont of host defense response (GO:0052509)3.43846219
24modulation by symbiont of host defense response (GO:0052031)3.43846219
25detection of molecule of bacterial origin (GO:0032490)3.39105636
26regulation of T-helper 1 cell differentiation (GO:0045625)3.38226547
27positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.37141544
28fat-soluble vitamin biosynthetic process (GO:0042362)3.30185850
29regulation of interferon-alpha production (GO:0032647)3.26116218
30myeloid dendritic cell differentiation (GO:0043011)3.25906334
31NIK/NF-kappaB signaling (GO:0038061)3.24732300
32ceramide catabolic process (GO:0046514)3.20817381
33virion attachment to host cell (GO:0019062)3.19237411
34adhesion of symbiont to host cell (GO:0044650)3.19237411
35negative regulation of cytokine production involved in immune response (GO:0002719)3.16139265
36monocyte chemotaxis (GO:0002548)3.14699104
37regulation of membrane protein ectodomain proteolysis (GO:0051043)3.11807878
38cellular response to type I interferon (GO:0071357)3.10598320
39type I interferon signaling pathway (GO:0060337)3.10598320
40germinal center formation (GO:0002467)3.10269763
41regulation of chronic inflammatory response (GO:0002676)3.08305461
42detection of other organism (GO:0098543)3.06370245
43response to type I interferon (GO:0034340)3.06337807
44interferon-gamma-mediated signaling pathway (GO:0060333)3.03491839
45regulation of chemokine biosynthetic process (GO:0045073)3.02428158
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01798618
47membrane lipid catabolic process (GO:0046466)3.00772271
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.00098580
49regulation of cholesterol storage (GO:0010885)2.96356126
50adhesion of symbiont to host (GO:0044406)2.95156032
51regulation of interferon-beta biosynthetic process (GO:0045357)2.95104707
52regulation of macrophage chemotaxis (GO:0010758)2.93619841
53detection of external biotic stimulus (GO:0098581)2.91924356
54angiotensin maturation (GO:0002003)2.91216991
55granulocyte activation (GO:0036230)2.89892557
56negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88976181
57positive regulation of type 2 immune response (GO:0002830)2.88825524
58branching involved in labyrinthine layer morphogenesis (GO:0060670)2.87880266
59regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87410404
60sphingolipid catabolic process (GO:0030149)2.87043429
61positive regulation of heat generation (GO:0031652)2.86329340
62myeloid dendritic cell activation (GO:0001773)2.84860581
63regulation of interleukin-8 biosynthetic process (GO:0045414)2.82593988
64negative regulation of nitric oxide biosynthetic process (GO:0045019)2.81999376
65response to thyroid hormone (GO:0097066)2.81717676
66positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.80476353
67defense response to protozoan (GO:0042832)2.80322547
68positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.79890964
69response to protozoan (GO:0001562)2.79119166
70regulation of fever generation (GO:0031620)2.78307304
71positive regulation of interferon-alpha production (GO:0032727)2.77753866
72regulation of T-helper 2 cell differentiation (GO:0045628)2.76700476
73B cell mediated immunity (GO:0019724)2.76269484
74cellular response to lipopolysaccharide (GO:0071222)2.75896948
75detection of bacterium (GO:0016045)2.75709365
76eosinophil chemotaxis (GO:0048245)2.74455977
77amino sugar catabolic process (GO:0046348)2.72515303
78low-density lipoprotein particle clearance (GO:0034383)2.71268761
79positive regulation of antigen processing and presentation (GO:0002579)2.71047277
80macrophage activation (GO:0042116)2.70905150
81cellular response to molecule of bacterial origin (GO:0071219)2.70030832
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69626594
83negative regulation of cell killing (GO:0031342)2.69626594
84positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68656312
85positive regulation of cellular amide metabolic process (GO:0034250)2.68398141
86regulation of antigen processing and presentation (GO:0002577)2.67743846
87negative regulation of myeloid cell apoptotic process (GO:0033033)2.67420164
88regulation of interleukin-12 production (GO:0032655)2.66822698
89positive regulation of monocyte chemotaxis (GO:0090026)2.65967517
90cellular extravasation (GO:0045123)2.65802893
91positive regulation of NF-kappaB import into nucleus (GO:0042346)2.64859914
92dendritic cell differentiation (GO:0097028)2.62923899
93regulation of mast cell degranulation (GO:0043304)2.61924964
94positive regulation of toll-like receptor signaling pathway (GO:0034123)2.61366182
95hydrogen peroxide biosynthetic process (GO:0050665)2.60500083
96detection of biotic stimulus (GO:0009595)2.60333848
97regulation of heterotypic cell-cell adhesion (GO:0034114)2.58036879
98myeloid cell activation involved in immune response (GO:0002275)2.57604143
99regulation of T cell tolerance induction (GO:0002664)2.57331121
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.57263062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.76064080
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.16622175
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.73225142
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.61891235
5* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.37368074
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.37195076
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.35491592
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.20485588
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07166804
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.05598862
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.72032722
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43661626
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40318594
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32669707
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29410012
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.26644486
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21855912
18VDR_24787735_ChIP-Seq_THP-1_Human2.19709075
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18832801
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09644098
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01247217
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.98877901
23VDR_24763502_ChIP-Seq_THP-1_Human1.93864820
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93738357
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92338628
26SPI1_23127762_ChIP-Seq_K562_Human1.86370285
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.85263655
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.76894815
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.76711137
30GATA1_22025678_ChIP-Seq_K562_Human1.73865137
31* SPI1_23547873_ChIP-Seq_NB4_Human1.69483558
32CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66288671
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.64990872
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63680354
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63144403
36VDR_21846776_ChIP-Seq_THP-1_Human1.61896978
37* ESR2_21235772_ChIP-Seq_MCF-7_Human1.60785839
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60371800
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51898230
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48930446
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48928368
42SCL_19346495_ChIP-Seq_HPC-7_Human1.44274041
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41171795
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39686893
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36653615
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35413917
47RUNX_20019798_ChIP-Seq_JUKART_Human1.35246096
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.34751334
49PU_27001747_Chip-Seq_BMDM_Mouse1.34405676
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.32821734
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32156494
52LXR_22292898_ChIP-Seq_THP-1_Human1.30313131
53CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28688538
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28043933
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22706326
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21909462
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.21016690
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.20236423
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17387955
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15633608
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15425770
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15401890
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13890971
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.13367070
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12802674
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.12783210
67MAF_26560356_Chip-Seq_TH1_Human1.09851635
68MYB_26560356_Chip-Seq_TH2_Human1.09651915
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09316377
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08809666
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08379180
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07094796
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06991570
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06246237
75GATA1_19941826_ChIP-Seq_K562_Human1.05474368
76TCF7_22412390_ChIP-Seq_EML_Mouse1.01421691
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98669382
78SOX2_20726797_ChIP-Seq_SW620_Human0.97023796
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95695548
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95253805
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95253805
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95253805
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94851468
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94192833
85GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93857000
86MYB_26560356_Chip-Seq_TH1_Human0.91398622
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91350982
88STAT1_20625510_ChIP-Seq_HELA_Human0.90949107
89GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90433474
90TFEB_21752829_ChIP-Seq_HELA_Human0.87941994
91TP63_17297297_ChIP-ChIP_HaCaT_Human0.87808792
92KDM2B_26808549_Chip-Seq_DND41_Human0.83798056
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83788946
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83684043
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83505929
96UTX_26944678_Chip-Seq_JUKART_Human0.83043088
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82914974
98CLOCK_20551151_ChIP-Seq_293T_Human0.82661611
99RACK7_27058665_Chip-Seq_MCF-7_Human0.82228245
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81879820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.34638784
2MP0005058_abnormal_lysosome_morphology3.75944959
3MP0002139_abnormal_hepatobiliary_system3.73640736
4MP0009840_abnormal_foam_cell3.53466596
5MP0006082_CNS_inflammation3.17659273
6MP0003724_increased_susceptibility_to3.13214138
7MP0002148_abnormal_hypersensitivity_rea3.04066847
8MP0009785_altered_susceptibility_to2.94874937
9MP0003436_decreased_susceptibility_to2.91812235
10MP0001835_abnormal_antigen_presentation2.55543494
11MP0002419_abnormal_innate_immunity2.45972478
12MP0005671_abnormal_response_to2.37965239
13MP0003300_gastrointestinal_ulcer2.33226824
14MP0004510_myositis2.33134759
15MP0001790_abnormal_immune_system2.31226773
16MP0005387_immune_system_phenotype2.31226773
17MP0005025_abnormal_response_to2.24837291
18MP0003191_abnormal_cellular_cholesterol2.21840282
19MP0005000_abnormal_immune_tolerance2.21020601
20MP0005451_abnormal_body_composition2.20356953
21MP0003806_abnormal_nucleotide_metabolis2.19879512
22MP0003075_altered_response_to2.09852582
23MP0008004_abnormal_stomach_pH2.03993074
24MP0003172_abnormal_lysosome_physiology1.99742274
25MP0009764_decreased_sensitivity_to1.99155817
26MP0000343_altered_response_to1.97046123
27MP0000604_amyloidosis1.94936499
28MP0003195_calcinosis1.93028841
29MP0002452_abnormal_antigen_presenting1.87682972
30MP0001533_abnormal_skeleton_physiology1.82213677
31MP0002723_abnormal_immune_serum1.79420548
32MP0010155_abnormal_intestine_physiology1.74544891
33MP0001853_heart_inflammation1.73319319
34MP0001800_abnormal_humoral_immune1.73249791
35MP0005365_abnormal_bile_salt1.71570803
36MP0002254_reproductive_system_inflammat1.71226621
37MP0004947_skin_inflammation1.70947864
38MP0006054_spinal_hemorrhage1.70129333
39MP0001845_abnormal_inflammatory_respons1.69531352
40MP0000685_abnormal_immune_system1.63839639
41MP0008469_abnormal_protein_level1.63459380
42MP0002138_abnormal_hepatobiliary_system1.62842420
43MP0002998_abnormal_bone_remodeling1.61613141
44MP0005360_urolithiasis1.61575949
45MP0003453_abnormal_keratinocyte_physiol1.56811622
46MP0001819_abnormal_immune_cell1.48697828
47MP0002420_abnormal_adaptive_immunity1.48295706
48MP0005166_decreased_susceptibility_to1.46335140
49MP0003183_abnormal_peptide_metabolism1.40721334
50MP0003448_altered_tumor_morphology1.39056248
51MP0005464_abnormal_platelet_physiology1.37047338
52MP0009278_abnormal_bone_marrow1.36263654
53MP0002405_respiratory_system_inflammati1.34261189
54MP0005167_abnormal_blood-brain_barrier1.32578388
55MP0005310_abnormal_salivary_gland1.32294124
56MP0009333_abnormal_splenocyte_physiolog1.31733552
57MP0003690_abnormal_glial_cell1.27539988
58MP0001545_abnormal_hematopoietic_system1.25321293
59MP0005397_hematopoietic_system_phenotyp1.25321293
60MP0002332_abnormal_exercise_endurance1.21404001
61MP0000858_altered_metastatic_potential1.19867913
62MP0008260_abnormal_autophagy1.19252370
63MP0005085_abnormal_gallbladder_physiolo1.13333348
64MP0000716_abnormal_immune_system1.02388346
65MP0003656_abnormal_erythrocyte_physiolo1.01479344
66MP0005164_abnormal_response_to0.97000304
67MP0004019_abnormal_vitamin_homeostasis0.93843366
68MP0003828_pulmonary_edema0.91353579
69MP0003329_amyloid_beta_deposits0.90707208
70MP0003091_abnormal_cell_migration0.89921412
71MP0001666_abnormal_nutrient_absorption0.88657336
72MP0005319_abnormal_enzyme/_coenzyme0.88297625
73MP0009763_increased_sensitivity_to0.87813627
74MP0005165_increased_susceptibility_to0.87801563
75MP0005647_abnormal_sex_gland0.87640561
76MP0000609_abnormal_liver_physiology0.85279999
77MP0000920_abnormal_myelination0.84592324
78MP0010234_abnormal_vibrissa_follicle0.80370909
79MP0004883_abnormal_blood_vessel0.77611789
80MP0002429_abnormal_blood_cell0.76459667
81MP0001764_abnormal_homeostasis0.76111803
82MP0002398_abnormal_bone_marrow0.74850540
83MP0000689_abnormal_spleen_morphology0.74570654
84MP0005410_abnormal_fertilization0.74425400
85MP0000465_gastrointestinal_hemorrhage0.73209144
86MP0000249_abnormal_blood_vessel0.72359040
87MP0005076_abnormal_cell_differentiation0.72299284
88MP0005023_abnormal_wound_healing0.72276181
89MP0002722_abnormal_immune_system0.69017750
90MP0001663_abnormal_digestive_system0.69014086
91MP0009765_abnormal_xenobiotic_induced0.67983832
92MP0005584_abnormal_enzyme/coenzyme_acti0.67593126
93MP0005390_skeleton_phenotype0.66505789
94MP0002877_abnormal_melanocyte_morpholog0.66188634
95MP0008874_decreased_physiological_sensi0.65619448
96MP0010307_abnormal_tumor_latency0.64144616
97MP0008875_abnormal_xenobiotic_pharmacok0.63719646
98MP0001542_abnormal_bone_strength0.62959789
99MP0002118_abnormal_lipid_homeostasis0.62634924
100MP0009115_abnormal_fat_cell0.61246497

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.70717275
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.70717275
3Abnormality of glycolipid metabolism (HP:0010969)6.70717275
4Systemic lupus erythematosus (HP:0002725)5.46811751
5Vacuolated lymphocytes (HP:0001922)5.09661471
6Abnormality of macrophages (HP:0004311)5.06059390
7Increased cerebral lipofuscin (HP:0011813)4.62847696
8Eczematoid dermatitis (HP:0000976)4.32317901
9Recurrent bacterial skin infections (HP:0005406)4.23835538
10Recurrent abscess formation (HP:0002722)4.14581954
11Loss of speech (HP:0002371)4.11496850
12Dysostosis multiplex (HP:0000943)4.03944378
13Recurrent gram-negative bacterial infections (HP:0005420)3.95188579
14Disinhibition (HP:0000734)3.90950736
15Orchitis (HP:0100796)3.86608446
16Retrobulbar optic neuritis (HP:0100654)3.74501746
17Optic neuritis (HP:0100653)3.74501746
18Glomerulonephritis (HP:0000099)3.74167514
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.72519912
20Myositis (HP:0100614)3.48200541
21Myocardial infarction (HP:0001658)3.44410530
22Mutism (HP:0002300)3.24507132
23Stomatitis (HP:0010280)3.22887307
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22531164
25Abnormality of polysaccharide metabolism (HP:0011012)3.22531164
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22531164
27Complement deficiency (HP:0004431)3.21508101
28Mediastinal lymphadenopathy (HP:0100721)3.18065864
29Autoimmune thrombocytopenia (HP:0001973)3.15977175
30Urinary glycosaminoglycan excretion (HP:0003541)3.11666894
31Mucopolysacchariduria (HP:0008155)3.11666894
32Axonal loss (HP:0003447)3.06574967
33Malnutrition (HP:0004395)2.98285962
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.89817084
35Amyloidosis (HP:0011034)2.84449234
36Neurofibrillary tangles (HP:0002185)2.81947363
37Increased serum ferritin (HP:0003281)2.79490185
38Nuclear cataract (HP:0100018)2.71610862
39Abnormality of complement system (HP:0005339)2.67020050
40Keratoconjunctivitis sicca (HP:0001097)2.59508009
41Nausea (HP:0002018)2.58822556
42Purpura (HP:0000979)2.55625631
43Gingivitis (HP:0000230)2.53213059
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49830044
45Abnormality of the vasculature of the conjunctiva (HP:0008054)2.49509583
46Metaphyseal irregularity (HP:0003025)2.48209367
47Pulmonary infiltrates (HP:0002113)2.43259013
48Recurrent skin infections (HP:0001581)2.42830232
49Hematochezia (HP:0002573)2.40975508
50Gangrene (HP:0100758)2.38280824
51Apathy (HP:0000741)2.37974176
52Diminished motivation (HP:0000745)2.33005660
53Obstructive lung disease (HP:0006536)2.31124918
54Chronic obstructive pulmonary disease (HP:0006510)2.31124918
55Increased IgM level (HP:0003496)2.30321438
56Keratoconjunctivitis (HP:0001096)2.29388593
57Vasculitis (HP:0002633)2.27449004
58Progressive neurologic deterioration (HP:0002344)2.26525055
59Interstitial pulmonary disease (HP:0006530)2.25847551
60Hemoptysis (HP:0002105)2.22308218
61Polyneuropathy (HP:0001271)2.21869280
62Abnormality of iron homeostasis (HP:0011031)2.21257818
63Agnosia (HP:0010524)2.19182138
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16917253
65Asymmetric septal hypertrophy (HP:0001670)2.16768952
66Xanthomatosis (HP:0000991)2.16049637
67Nephritis (HP:0000123)2.13820547
68Thin bony cortex (HP:0002753)2.12138948
69Deep venous thrombosis (HP:0002625)2.11354642
70Hepatosplenomegaly (HP:0001433)2.10050630
71Intrahepatic cholestasis (HP:0001406)2.07880316
72Neuronal loss in central nervous system (HP:0002529)2.06636564
73Peripheral demyelination (HP:0011096)2.06105228
74Recurrent fungal infections (HP:0002841)2.05308857
75Cerebral inclusion bodies (HP:0100314)2.05240349
76Upper motor neuron abnormality (HP:0002127)2.04158405
77Pathologic fracture (HP:0002756)2.01821217
78Bone pain (HP:0002653)2.00438560
79Petechiae (HP:0000967)2.00038008
80Thoracic kyphosis (HP:0002942)1.99765355
81Esophageal varix (HP:0002040)1.99566816
82Dementia (HP:0000726)1.96406633
83Prolonged neonatal jaundice (HP:0006579)1.95778953
84Spontaneous hematomas (HP:0007420)1.93098790
85Inappropriate behavior (HP:0000719)1.92170665
86Pulmonary embolism (HP:0002204)1.92126049
87T lymphocytopenia (HP:0005403)1.91581471
88Urticaria (HP:0001025)1.90949100
89Arterial thrombosis (HP:0004420)1.90161626
90Basal ganglia calcification (HP:0002135)1.88901873
91Retinal atrophy (HP:0001105)1.87842159
92Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86621639
93Meningitis (HP:0001287)1.86321568
94Anorexia (HP:0002039)1.86078418
95Protuberant abdomen (HP:0001538)1.85815469
96Hypophosphatemia (HP:0002148)1.82471010
97Recurrent viral infections (HP:0004429)1.82432462
98Abnormality of T cell number (HP:0011839)1.82102298
99Abnormality of transition element cation homeostasis (HP:0011030)1.80936158
100Encephalitis (HP:0002383)1.77877228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.61372796
2NME23.55133543
3GRK73.16506355
4MAP3K143.06049270
5BLK2.69578484
6ACVR1B2.62347952
7DDR22.60192026
8RIPK42.53842494
9TYK22.53600346
10PRPF4B2.46695244
11TBK12.43255210
12MATK2.39915577
13TAOK22.38004253
14TGFBR22.34728593
15CSK2.14801984
16RIPK12.14515820
17FGR2.12576073
18MAP3K32.12424779
19ERN12.12112644
20MOS2.07109774
21IRAK41.98799724
22IKBKB1.71804057
23IKBKE1.70385439
24MAP3K131.69518601
25MAP2K31.57632636
26MAP4K11.57527835
27MAP3K111.52932658
28TAOK11.46270229
29CDC42BPA1.45881172
30TXK1.44420863
31MAP3K11.38149297
32JAK31.36294756
33ZAP701.36011292
34MARK31.26629771
35LATS21.20526853
36PIM21.20481639
37JAK11.18558486
38CSF1R1.14826259
39BMPR21.12964649
40ABL21.11803455
41IRAK21.06847078
42CHUK1.05165329
43STK101.04266839
44JAK21.02409619
45MAP3K51.00651862
46ADRBK21.00457944
47ARAF0.92466197
48IRAK10.91887654
49TESK20.90980570
50PDPK10.87384485
51LYN0.85685678
52SYK0.72678233
53NEK90.71532281
54TESK10.71302668
55TYRO30.67629492
56PAK40.67445550
57PDK20.66926893
58PDK10.66604141
59KSR20.65537162
60PIM10.65388771
61LCK0.64285903
62FGFR40.63112977
63HCK0.61452810
64SIK30.58946767
65FES0.58643598
66MELK0.57472755
67EPHB10.57174238
68CDK60.57166500
69PRKG20.55055883
70BTK0.54346588
71CLK10.47844481
72CAMKK20.46337302
73TRIB30.46083149
74CAMK1D0.45861493
75SIK10.44541854
76PDGFRA0.44148852
77MST1R0.42517897
78MAP3K80.41542851
79PRKAA20.35125828
80BMX0.34934430
81MAP3K90.32954736
82MAP3K20.32761329
83MAPKAPK20.32686022
84ABL10.31979257
85KIT0.31763134
86DAPK20.30290848
87EGFR0.29731842
88RPS6KC10.29201180
89RPS6KL10.29201180
90MAP2K60.29078202
91NLK0.28975257
92MAPK70.26969482
93ICK0.26687608
94MAPK40.25607410
95DYRK30.24175333
96RPS6KA20.23740117
97FGFR30.23695236
98STK240.21964142
99EPHA30.21455124
100GSK3A0.21396875

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.25961079
2Staphylococcus aureus infection_Homo sapiens_hsa051503.12084428
3Lysosome_Homo sapiens_hsa041422.67545885
4Osteoclast differentiation_Homo sapiens_hsa043802.55755011
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.52067375
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.45562517
7Leishmaniasis_Homo sapiens_hsa051402.40734037
8Rheumatoid arthritis_Homo sapiens_hsa053232.37404862
9Allograft rejection_Homo sapiens_hsa053302.28717012
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.12267833
11Asthma_Homo sapiens_hsa053102.10505831
12Pertussis_Homo sapiens_hsa051332.04246310
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.01560952
14Tuberculosis_Homo sapiens_hsa051521.97216224
15Malaria_Homo sapiens_hsa051441.95816379
16Graft-versus-host disease_Homo sapiens_hsa053321.91386634
17Autoimmune thyroid disease_Homo sapiens_hsa053201.89381298
18TNF signaling pathway_Homo sapiens_hsa046681.85667732
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84081479
20Legionellosis_Homo sapiens_hsa051341.83798271
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82451113
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77977593
23Complement and coagulation cascades_Homo sapiens_hsa046101.74698612
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.64938845
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53065910
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51334777
27Phagosome_Homo sapiens_hsa041451.45392646
28Influenza A_Homo sapiens_hsa051641.43206287
29Salmonella infection_Homo sapiens_hsa051321.38713182
30Toxoplasmosis_Homo sapiens_hsa051451.38094780
31African trypanosomiasis_Homo sapiens_hsa051431.35574276
32Antigen processing and presentation_Homo sapiens_hsa046121.31797054
33Type I diabetes mellitus_Homo sapiens_hsa049401.30078422
34Hematopoietic cell lineage_Homo sapiens_hsa046401.27730599
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.19799642
36Prion diseases_Homo sapiens_hsa050201.18257921
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15515039
38PPAR signaling pathway_Homo sapiens_hsa033201.14797520
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09740903
40Viral myocarditis_Homo sapiens_hsa054161.08634072
41Mineral absorption_Homo sapiens_hsa049781.08537728
42B cell receptor signaling pathway_Homo sapiens_hsa046621.05669848
43Sphingolipid metabolism_Homo sapiens_hsa006001.02783325
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02500777
45Hepatitis C_Homo sapiens_hsa051601.02005184
46Herpes simplex infection_Homo sapiens_hsa051681.01030751
47Chemokine signaling pathway_Homo sapiens_hsa040621.00951979
48Measles_Homo sapiens_hsa051620.99681301
49Galactose metabolism_Homo sapiens_hsa000520.99246624
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98580916
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90320101
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89316724
53Renin-angiotensin system_Homo sapiens_hsa046140.88819903
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88172483
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.87883643
56Apoptosis_Homo sapiens_hsa042100.85936151
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84627128
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.82994937
59Amoebiasis_Homo sapiens_hsa051460.80971471
60Sulfur metabolism_Homo sapiens_hsa009200.80758192
61Hepatitis B_Homo sapiens_hsa051610.77763614
62Acute myeloid leukemia_Homo sapiens_hsa052210.76120157
63Tryptophan metabolism_Homo sapiens_hsa003800.75900762
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.71660374
65Shigellosis_Homo sapiens_hsa051310.71629174
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71058903
67Fructose and mannose metabolism_Homo sapiens_hsa000510.68953184
68Bladder cancer_Homo sapiens_hsa052190.64203666
69T cell receptor signaling pathway_Homo sapiens_hsa046600.61657956
70Caffeine metabolism_Homo sapiens_hsa002320.59006227
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57746666
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56213727
73Starch and sucrose metabolism_Homo sapiens_hsa005000.56019914
74Collecting duct acid secretion_Homo sapiens_hsa049660.52687801
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.52448197
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52422797
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.50384990
78Chemical carcinogenesis_Homo sapiens_hsa052040.50130624
79Fatty acid degradation_Homo sapiens_hsa000710.45018118
80Prolactin signaling pathway_Homo sapiens_hsa049170.44469610
81Primary immunodeficiency_Homo sapiens_hsa053400.43012462
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.41761317
83VEGF signaling pathway_Homo sapiens_hsa043700.40498444
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39165943
85Histidine metabolism_Homo sapiens_hsa003400.38935513
86Insulin resistance_Homo sapiens_hsa049310.38819353
87Epstein-Barr virus infection_Homo sapiens_hsa051690.37859018
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36987278
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36155909
90HIF-1 signaling pathway_Homo sapiens_hsa040660.35402701
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35084698
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31124020
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30765396
94Vibrio cholerae infection_Homo sapiens_hsa051100.30041287
95Bile secretion_Homo sapiens_hsa049760.27654106
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27248796
97Glutathione metabolism_Homo sapiens_hsa004800.26788888
98Retinol metabolism_Homo sapiens_hsa008300.26628833
99Phenylalanine metabolism_Homo sapiens_hsa003600.25363495
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.24617167

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