FLYWCH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.45647394
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.19676110
3ATP synthesis coupled proton transport (GO:0015986)6.19676110
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.41133335
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.32041168
6neuron cell-cell adhesion (GO:0007158)5.09412908
7base-excision repair, AP site formation (GO:0006285)4.82365773
8protein maturation by protein folding (GO:0022417)4.77359369
9regulation of mitochondrial translation (GO:0070129)4.71339430
10respiratory electron transport chain (GO:0022904)4.69018979
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.62571056
12electron transport chain (GO:0022900)4.61465672
13vocalization behavior (GO:0071625)4.49426111
14viral transcription (GO:0019083)4.44599626
15postsynaptic membrane organization (GO:0001941)4.27969247
16translational termination (GO:0006415)4.26135780
17chaperone-mediated protein transport (GO:0072321)4.24862903
18GTP biosynthetic process (GO:0006183)4.16708510
19deoxyribonucleotide catabolic process (GO:0009264)4.15022479
20purine deoxyribonucleotide catabolic process (GO:0009155)4.11622486
21protein retention in ER lumen (GO:0006621)4.04774453
22GDP-mannose metabolic process (GO:0019673)4.01596623
23metallo-sulfur cluster assembly (GO:0031163)3.95326051
24iron-sulfur cluster assembly (GO:0016226)3.95326051
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.93500989
26protein complex biogenesis (GO:0070271)3.89904040
27deoxyribose phosphate catabolic process (GO:0046386)3.88601129
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.86675229
29NADH dehydrogenase complex assembly (GO:0010257)3.86675229
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86675229
31ribosomal small subunit biogenesis (GO:0042274)3.78174125
32ribosomal small subunit assembly (GO:0000028)3.78110531
33cotranslational protein targeting to membrane (GO:0006613)3.76560001
34pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.75836196
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.72937730
36protein insertion into membrane (GO:0051205)3.71742106
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.71391118
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.70335257
39protein targeting to ER (GO:0045047)3.68273260
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.65366106
41presynaptic membrane assembly (GO:0097105)3.65151661
42protein localization to synapse (GO:0035418)3.60886769
43pyrimidine nucleotide catabolic process (GO:0006244)3.58597741
44pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.58215591
45inner mitochondrial membrane organization (GO:0007007)3.57099349
46translational elongation (GO:0006414)3.55533065
47protein localization to cilium (GO:0061512)3.54418607
48mitochondrial respiratory chain complex assembly (GO:0033108)3.53912230
49peptidyl-arginine omega-N-methylation (GO:0035247)3.53676271
50positive regulation of synapse assembly (GO:0051965)3.52538255
51UTP biosynthetic process (GO:0006228)3.52511922
52protein localization to endoplasmic reticulum (GO:0070972)3.51273083
53Golgi transport vesicle coating (GO:0048200)3.49668834
54COPI coating of Golgi vesicle (GO:0048205)3.49668834
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.49510452
56cellular protein complex disassembly (GO:0043624)3.49059382
57guanosine-containing compound biosynthetic process (GO:1901070)3.48409323
58response to histamine (GO:0034776)3.47849303
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47252601
60peptidyl-histidine modification (GO:0018202)3.40984095
61mannosylation (GO:0097502)3.40464069
62viral life cycle (GO:0019058)3.40388374
63purine nucleoside triphosphate biosynthetic process (GO:0009145)3.35740095
642-deoxyribonucleotide metabolic process (GO:0009394)3.35326806
65hydrogen ion transmembrane transport (GO:1902600)3.34687295
66DNA deamination (GO:0045006)3.33630646
67nucleobase-containing small molecule interconversion (GO:0015949)3.32166098
682-deoxyribonucleotide biosynthetic process (GO:0009265)3.31877040
69deoxyribose phosphate biosynthetic process (GO:0046385)3.31877040
70ATP biosynthetic process (GO:0006754)3.30311007
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29970668
72regulation of glutamate receptor signaling pathway (GO:1900449)3.29560902
73ubiquinone biosynthetic process (GO:0006744)3.27734459
74protein localization to mitochondrion (GO:0070585)3.27319543
75positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.27206669
76synaptic vesicle exocytosis (GO:0016079)3.23734953
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23378825
78pentose metabolic process (GO:0019321)3.22028497
79deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.21274882
80lipopolysaccharide biosynthetic process (GO:0009103)3.19413038
81regulation of cellular amino acid metabolic process (GO:0006521)3.17917454
82pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.17504100
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15292795
84mitotic nuclear envelope reassembly (GO:0007084)3.14853952
85nuclear envelope reassembly (GO:0031468)3.14853952
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.14385407
87nucleotide salvage (GO:0043173)3.13911038
88negative regulation of microtubule polymerization (GO:0031115)3.13597453
89presynaptic membrane organization (GO:0097090)3.13420482
90deoxyribose phosphate metabolic process (GO:0019692)3.12991226
91positive regulation of TOR signaling (GO:0032008)3.11871687
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11509262
93regulation of response to food (GO:0032095)3.11305182
94telomere maintenance via semi-conservative replication (GO:0032201)3.11270712
95protein deneddylation (GO:0000338)3.10576756
96response to pheromone (GO:0019236)3.10320469
97termination of RNA polymerase III transcription (GO:0006386)3.09102031
98transcription elongation from RNA polymerase III promoter (GO:0006385)3.09102031
99ribonucleoside triphosphate biosynthetic process (GO:0009201)3.08282296
100protein complex disassembly (GO:0043241)3.06796992
101negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.05485214
102deoxyribonucleotide metabolic process (GO:0009262)3.03156315
103macromolecular complex disassembly (GO:0032984)3.02470170
104purine deoxyribonucleotide metabolic process (GO:0009151)3.02412927
105respiratory system process (GO:0003016)3.01282188
106negative regulation of ligase activity (GO:0051352)3.00097367
107negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00097367
108establishment of integrated proviral latency (GO:0075713)2.98742699
109ubiquinone metabolic process (GO:0006743)2.97780448
110DNA strand elongation involved in DNA replication (GO:0006271)2.96842998
111CTP biosynthetic process (GO:0006241)2.95905965
112CTP metabolic process (GO:0046036)2.95905965
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95537290
114negative regulation of cell size (GO:0045792)2.94283586
115maturation of SSU-rRNA (GO:0030490)2.94050146
116positive regulation of mitochondrial fission (GO:0090141)2.93188851
117proline biosynthetic process (GO:0006561)2.91483740
118proteasome assembly (GO:0043248)2.89347026
119histone arginine methylation (GO:0034969)2.88960668
120proton transport (GO:0015992)2.88430241
121UTP metabolic process (GO:0046051)2.87491099
122synaptic transmission, dopaminergic (GO:0001963)2.86050437
123dopamine biosynthetic process (GO:0042416)2.85403962
124DNA strand elongation (GO:0022616)2.85391365
125de novo posttranslational protein folding (GO:0051084)2.85358739
126translational initiation (GO:0006413)2.82807189
127regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82044868
128hydrogen transport (GO:0006818)2.79800635
129virion assembly (GO:0019068)2.79637090
130cullin deneddylation (GO:0010388)2.79499730
131NADH metabolic process (GO:0006734)2.79377592
132pseudouridine synthesis (GO:0001522)2.79108739
133ribosome biogenesis (GO:0042254)2.78473100
134dopamine transport (GO:0015872)2.77898719
135mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.77691952
136mitochondrial calcium ion transport (GO:0006851)2.76543524
137ionotropic glutamate receptor signaling pathway (GO:0035235)2.75940957
138establishment of viral latency (GO:0019043)2.75797481
139epithelial cilium movement (GO:0003351)2.75523396
140cellular response to nitric oxide (GO:0071732)2.75365671
141DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75051277
142regulation of protein kinase A signaling (GO:0010738)2.74767177
143regulation of synapse assembly (GO:0051963)2.74691842
144peptidyl-arginine methylation (GO:0018216)2.74287174
145peptidyl-arginine N-methylation (GO:0035246)2.74287174
146purine nucleotide salvage (GO:0032261)2.74193257
147anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74155984
148transcription-coupled nucleotide-excision repair (GO:0006283)2.71071009
149cellular component biogenesis (GO:0044085)2.71029547
150de novo protein folding (GO:0006458)2.70998954
151positive regulation of membrane potential (GO:0045838)2.70217871
152glutamate receptor signaling pathway (GO:0007215)2.69729358
153protein-cofactor linkage (GO:0018065)2.65958613
154deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.65199088
155positive regulation of synaptic transmission, GABAergic (GO:0032230)2.63058478
156nucleoside triphosphate biosynthetic process (GO:0009142)2.62844073
157positive regulation of dendritic spine development (GO:0060999)2.62619344
158neuron-neuron synaptic transmission (GO:0007270)2.62588765
159neuron recognition (GO:0008038)2.61924838
160positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.61474846
161synaptic transmission, glutamatergic (GO:0035249)2.61376488
162DNA damage response, detection of DNA damage (GO:0042769)2.60608092
163oxidative phosphorylation (GO:0006119)2.60480858
164opioid receptor signaling pathway (GO:0038003)2.60017687
165neuronal action potential propagation (GO:0019227)2.59068758
166dendritic spine morphogenesis (GO:0060997)2.57540377
167pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.56881970
168protein targeting to mitochondrion (GO:0006626)2.55529949
169pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.54456409
170exploration behavior (GO:0035640)2.54115446
171establishment of protein localization to mitochondrion (GO:0072655)2.53550103
172respiratory chain complex IV assembly (GO:0008535)2.53332882
173ATP hydrolysis coupled proton transport (GO:0015991)2.52619581
174energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.52619581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87781046
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94894033
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41703529
4BMI1_23680149_ChIP-Seq_NPCS_Mouse3.11865895
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03572856
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80957683
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.76965493
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70109251
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69164708
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68462563
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.67071373
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.64122341
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.60735594
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.59618637
15ZNF263_19887448_ChIP-Seq_K562_Human2.48467080
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.42823242
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42068269
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39946104
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35777183
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34892214
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.33478456
22* GABP_19822575_ChIP-Seq_HepG2_Human2.32995695
23TAF15_26573619_Chip-Seq_HEK293_Human2.31341584
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31114871
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31114871
26GBX2_23144817_ChIP-Seq_PC3_Human2.29076578
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27140775
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26726927
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.22101680
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19409677
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.16816117
32DCP1A_22483619_ChIP-Seq_HELA_Human2.13856628
33REST_21632747_ChIP-Seq_MESCs_Mouse2.11708756
34E2F7_22180533_ChIP-Seq_HELA_Human2.06749239
35MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00939776
36E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00100341
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99428256
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.98154232
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97629766
40RNF2_27304074_Chip-Seq_NSC_Mouse1.96434114
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87985588
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87324327
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87320055
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.86830533
45FUS_26573619_Chip-Seq_HEK293_Human1.86465666
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83274818
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76893097
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.76472003
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75963591
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75122751
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.69475707
52ZNF274_21170338_ChIP-Seq_K562_Hela1.68730551
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.67494768
54IGF1R_20145208_ChIP-Seq_DFB_Human1.65303774
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60271309
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57376426
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55623403
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54109193
59P68_20966046_ChIP-Seq_HELA_Human1.53226528
60FOXP3_21729870_ChIP-Seq_TREG_Human1.53092722
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52879291
62LXR_22292898_ChIP-Seq_THP-1_Human1.51745046
63VDR_21846776_ChIP-Seq_THP-1_Human1.51258982
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50536432
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50203570
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.48483662
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47568597
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46493511
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.44236301
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42633449
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41991006
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40711227
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40343719
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39767946
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.38245734
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.37744972
77KDM5A_27292631_Chip-Seq_BREAST_Human1.37130199
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36602938
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.36135434
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.35988916
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33917878
82VDR_23849224_ChIP-Seq_CD4+_Human1.33707807
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31894560
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29509115
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26654677
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26519968
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26341684
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25564202
89CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24758901
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23826628
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23129580
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.22881054
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22648117
94* RING1B_27294783_Chip-Seq_ESCs_Mouse1.22549569
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22466200
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21757523
97CIITA_25753668_ChIP-Seq_RAJI_Human1.21387284
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.20731236
99BCL6_27268052_Chip-Seq_Bcells_Human1.20473810
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20340171
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19956229
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19759290
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19160248
104P300_19829295_ChIP-Seq_ESCs_Human1.18950200
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.18743452
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.18720473
107TBX5_21415370_ChIP-Seq_HL-1_Mouse1.18464064
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17854348
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15862096
110RACK7_27058665_Chip-Seq_MCF-7_Human1.14632258
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14610565
112TTF2_22483619_ChIP-Seq_HELA_Human1.13910193
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12590691
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12496641
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12323154
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12287305
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12148391
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11468407
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11348240
120HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09847593
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09054308
122* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08585525
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08194723
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06707508
125VDR_22108803_ChIP-Seq_LS180_Human1.06532810
126BCOR_27268052_Chip-Seq_Bcells_Human1.05880060
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05143634
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.04744733
129PHF8_20622854_ChIP-Seq_HELA_Human1.04665046
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04457079
131RARB_24833708_ChIP-Seq_LIVER_Mouse1.04380221
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04360258
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03135669
134SMC4_20622854_ChIP-Seq_HELA_Human1.02360022
135SA1_27219007_Chip-Seq_ERYTHROID_Human1.02104062
136AR_21572438_ChIP-Seq_LNCaP_Human1.01694548
137TFEB_21752829_ChIP-Seq_HELA_Human1.00642866
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00352207
139RING1B_27294783_Chip-Seq_NPCs_Mouse1.00193709
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99761384
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97579931
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.97284955
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96896648
144SOX2_16153702_ChIP-ChIP_HESCs_Human0.96782586
145E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95928519
146XRN2_22483619_ChIP-Seq_HELA_Human0.95127602
147DROSHA_22980978_ChIP-Seq_HELA_Human0.94653326
148MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94192802
149SRF_21415370_ChIP-Seq_HL-1_Mouse0.94029784
150RARB_27405468_Chip-Seq_BRAIN_Mouse0.92602309
151MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92177642
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91765033
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91573787
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.89111860
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87785150
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87076287
157JUN_21703547_ChIP-Seq_K562_Human0.85975586
158SMAD3_21741376_ChIP-Seq_EPCs_Human0.84984279
159CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83573708
160CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82087718
161POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81838444
162POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81722964
163TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81722964
164UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81487317
165ELK1_22589737_ChIP-Seq_MCF10A_Human0.81449247
166CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80897941
167ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78792195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.48796204
2MP0006276_abnormal_autonomic_nervous3.40207077
3MP0009278_abnormal_bone_marrow3.10721264
4MP0003186_abnormal_redox_activity3.06983846
5MP0009379_abnormal_foot_pigmentation3.01283302
6MP0003806_abnormal_nucleotide_metabolis2.98762137
7MP0005058_abnormal_lysosome_morphology2.92117998
8MP0003122_maternal_imprinting2.87241631
9MP0001968_abnormal_touch/_nociception2.86701014
10MP0001984_abnormal_olfaction2.63615174
11MP0001529_abnormal_vocalization2.63451908
12MP0006036_abnormal_mitochondrial_physio2.55330628
13MP0005645_abnormal_hypothalamus_physiol2.54985639
14MP0003786_premature_aging2.47774409
15MP0004859_abnormal_synaptic_plasticity2.47525283
16MP0002736_abnormal_nociception_after2.46159935
17MP0001188_hyperpigmentation2.44380171
18MP0010030_abnormal_orbit_morphology2.42605749
19MP0003693_abnormal_embryo_hatching2.42586182
20MP0000750_abnormal_muscle_regeneration2.42236370
21MP0005423_abnormal_somatic_nervous2.41432390
22MP0003635_abnormal_synaptic_transmissio2.33971164
23MP0002735_abnormal_chemical_nociception2.22188534
24MP0009745_abnormal_behavioral_response2.17675472
25MP0006035_abnormal_mitochondrial_morpho2.16409757
26MP0008260_abnormal_autophagy2.14875484
27MP0008058_abnormal_DNA_repair2.13918216
28MP0001905_abnormal_dopamine_level2.11007231
29MP0002184_abnormal_innervation2.08763069
30MP0006292_abnormal_olfactory_placode2.03602106
31MP0005646_abnormal_pituitary_gland2.03471298
32MP0009840_abnormal_foam_cell2.02352701
33MP0000358_abnormal_cell_content/1.96188408
34MP0002063_abnormal_learning/memory/cond1.96090149
35MP0004142_abnormal_muscle_tone1.94615589
36MP0004233_abnormal_muscle_weight1.94372503
37MP0005394_taste/olfaction_phenotype1.92171033
38MP0005499_abnormal_olfactory_system1.92171033
39MP0002734_abnormal_mechanical_nocicepti1.91380408
40MP0008932_abnormal_embryonic_tissue1.90562904
41MP0002572_abnormal_emotion/affect_behav1.88822920
42MP0002272_abnormal_nervous_system1.87955721
43MP0004270_analgesia1.83945154
44MP0002557_abnormal_social/conspecific_i1.83502644
45MP0000372_irregular_coat_pigmentation1.82160980
46MP0008438_abnormal_cutaneous_collagen1.81238649
47MP0006072_abnormal_retinal_apoptosis1.81133400
48MP0001486_abnormal_startle_reflex1.80524716
49MP0001727_abnormal_embryo_implantation1.80144585
50MP0002064_seizures1.79074128
51MP0000013_abnormal_adipose_tissue1.77370694
52MP0002067_abnormal_sensory_capabilities1.77361407
53MP0001501_abnormal_sleep_pattern1.74971373
54MP0001986_abnormal_taste_sensitivity1.74752793
55MP0008789_abnormal_olfactory_epithelium1.71350717
56MP0001542_abnormal_bone_strength1.71252516
57MP0002733_abnormal_thermal_nociception1.71125288
58MP0002102_abnormal_ear_morphology1.70839268
59MP0005171_absent_coat_pigmentation1.65866633
60MP0002751_abnormal_autonomic_nervous1.65390654
61MP0009046_muscle_twitch1.62410032
62MP0004885_abnormal_endolymph1.57406145
63MP0003121_genomic_imprinting1.52518336
64MP0005623_abnormal_meninges_morphology1.52259525
65MP0000049_abnormal_middle_ear1.52040880
66MP0004858_abnormal_nervous_system1.51108439
67MP0000631_abnormal_neuroendocrine_gland1.49648727
68MP0003787_abnormal_imprinting1.49605783
69MP0003111_abnormal_nucleus_morphology1.49014190
70MP0005379_endocrine/exocrine_gland_phen1.48298989
71MP0003123_paternal_imprinting1.46258592
72MP0001661_extended_life_span1.45929144
73MP0001970_abnormal_pain_threshold1.45035857
74MP0003879_abnormal_hair_cell1.44048883
75MP0000003_abnormal_adipose_tissue1.42578203
76MP0002638_abnormal_pupillary_reflex1.40065143
77MP0000747_muscle_weakness1.37863736
78MP0002837_dystrophic_cardiac_calcinosis1.37365349
79MP0002938_white_spotting1.36976740
80MP0000778_abnormal_nervous_system1.36957133
81MP0002909_abnormal_adrenal_gland1.36877440
82MP0010094_abnormal_chromosome_stability1.36823947
83MP0004924_abnormal_behavior1.35763621
84MP0005386_behavior/neurological_phenoty1.35763621
85MP0001440_abnormal_grooming_behavior1.34885901
86MP0001764_abnormal_homeostasis1.33883149
87MP0003718_maternal_effect1.32797274
88MP0000026_abnormal_inner_ear1.30405454
89MP0003315_abnormal_perineum_morphology1.30370929
90MP0002877_abnormal_melanocyte_morpholog1.29342650
91MP0002160_abnormal_reproductive_system1.28208294
92MP0008007_abnormal_cellular_replicative1.27816329
93MP0004133_heterotaxia1.25256288
94MP0000955_abnormal_spinal_cord1.20835014
95MP0005330_cardiomyopathy1.19895098
96MP0001963_abnormal_hearing_physiology1.19363183
97MP0004742_abnormal_vestibular_system1.18701238
98MP0002752_abnormal_somatic_nervous1.18284416
99MP0002882_abnormal_neuron_morphology1.18169338
100MP0002277_abnormal_respiratory_mucosa1.16690143
101MP0000566_synostosis1.14686165
102MP0001502_abnormal_circadian_rhythm1.11423519
103MP0003077_abnormal_cell_cycle1.09865552
104MP0005397_hematopoietic_system_phenotyp1.09567651
105MP0001545_abnormal_hematopoietic_system1.09567651
106MP0004811_abnormal_neuron_physiology1.07393942
107MP0001664_abnormal_digestion1.07306508
108MP0005551_abnormal_eye_electrophysiolog1.06405381
109MP0000759_abnormal_skeletal_muscle1.04997664
110MP0002163_abnormal_gland_morphology1.04284104
111MP0002653_abnormal_ependyma_morphology1.02065293
112MP0005451_abnormal_body_composition1.00316274
113MP0003942_abnormal_urinary_system0.98118773
114MP0009250_abnormal_appendicular_skeleto0.94909450
115MP0003136_yellow_coat_color0.94580157
116MP0008872_abnormal_physiological_respon0.94384332
117MP0010386_abnormal_urinary_bladder0.94229410
118MP0002066_abnormal_motor_capabilities/c0.94036772
119MP0005409_darkened_coat_color0.92991710
120MP0005083_abnormal_biliary_tract0.90871181
121MP0000751_myopathy0.90630421
122MP0000749_muscle_degeneration0.90571324
123MP0005084_abnormal_gallbladder_morpholo0.89999340
124MP0005647_abnormal_sex_gland0.89859197
125MP0005670_abnormal_white_adipose0.89622897
126MP0002249_abnormal_larynx_morphology0.89386166
127MP0008995_early_reproductive_senescence0.87487673
128MP0000678_abnormal_parathyroid_gland0.87329974
129MP0003938_abnormal_ear_development0.87168820
130MP0002295_abnormal_pulmonary_circulatio0.86715748
131MP0002152_abnormal_brain_morphology0.86662811
132MP0001485_abnormal_pinna_reflex0.85023526
133MP0002132_abnormal_respiratory_system0.83951007
134MP0009384_cardiac_valve_regurgitation0.81937471
135MP0002822_catalepsy0.81341991
136MP0002069_abnormal_eating/drinking_beha0.80447066
137MP0002234_abnormal_pharynx_morphology0.80277761
138MP0005508_abnormal_skeleton_morphology0.80125089
139MP0004957_abnormal_blastocyst_morpholog0.78530498
140MP0005501_abnormal_skin_physiology0.78456782
141MP0005389_reproductive_system_phenotype0.78378224
142MP0005253_abnormal_eye_physiology0.77747179
143MP0002970_abnormal_white_adipose0.77715198
144MP0001270_distended_abdomen0.76671078
145MP0002233_abnormal_nose_morphology0.76656655
146MP0003137_abnormal_impulse_conducting0.76000946
147MP0003011_delayed_dark_adaptation0.75540819
148MP0005384_cellular_phenotype0.75126407
149MP0005174_abnormal_tail_pigmentation0.75070766
150MP0001243_abnormal_dermal_layer0.74215886
151MP0005410_abnormal_fertilization0.73284903
152MP0008569_lethality_at_weaning0.73104637
153MP0000313_abnormal_cell_death0.72735180
154MP0003119_abnormal_digestive_system0.72290190
155MP0001881_abnormal_mammary_gland0.71881022
156MP0000639_abnormal_adrenal_gland0.71337188
157MP0002090_abnormal_vision0.71188749
158MP0003861_abnormal_nervous_system0.70884365
159MP0002282_abnormal_trachea_morphology0.69761893
160MP0000681_abnormal_thyroid_gland0.68079476
161MP0008875_abnormal_xenobiotic_pharmacok0.68075001
162MP0005075_abnormal_melanosome_morpholog0.67831376
163MP0002269_muscular_atrophy0.65643400
164MP0000516_abnormal_urinary_system0.63962760
165MP0005367_renal/urinary_system_phenotyp0.63962760
166MP0003329_amyloid_beta_deposits0.63882601
167MP0000490_abnormal_crypts_of0.63803186
168MP0003221_abnormal_cardiomyocyte_apopto0.61334703
169MP0000462_abnormal_digestive_system0.61279299
170MP0002080_prenatal_lethality0.61195811
171MP0005266_abnormal_metabolism0.58907798

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.45386119
2Mitochondrial inheritance (HP:0001427)4.86373901
3Abnormal mitochondria in muscle tissue (HP:0008316)4.66695744
4Progressive macrocephaly (HP:0004481)4.60974542
5Increased hepatocellular lipid droplets (HP:0006565)4.01376991
6Increased CSF lactate (HP:0002490)3.99976568
7Acute encephalopathy (HP:0006846)3.97958473
8Ragged-red muscle fibers (HP:0003200)3.96759637
9Microvesicular hepatic steatosis (HP:0001414)3.74631352
10Hepatocellular necrosis (HP:0001404)3.67369991
11Limb dystonia (HP:0002451)3.66612532
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.58893524
13Myokymia (HP:0002411)3.53729675
14Focal motor seizures (HP:0011153)3.52304192
15Renal Fanconi syndrome (HP:0001994)3.49397254
16Testicular atrophy (HP:0000029)3.33246980
17Progressive muscle weakness (HP:0003323)3.33117073
18Abnormality of glycolysis (HP:0004366)3.25132267
19Lipid accumulation in hepatocytes (HP:0006561)3.25078498
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.18525359
21Increased serum pyruvate (HP:0003542)3.08948399
22Hypokinesia (HP:0002375)3.04465710
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98690387
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98690387
25Hypothermia (HP:0002045)2.92056924
26Optic disc pallor (HP:0000543)2.89513717
27Abnormality of cells of the erythroid lineage (HP:0012130)2.86903677
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.86344425
29Reticulocytopenia (HP:0001896)2.85755357
30Exercise intolerance (HP:0003546)2.79586289
31Abnormal hair whorl (HP:0010721)2.79193660
32Type I transferrin isoform profile (HP:0003642)2.78672394
33Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78494134
34Dicarboxylic aciduria (HP:0003215)2.78494134
35Abnormal respiratory motile cilium morphology (HP:0005938)2.78125815
36Abnormal respiratory epithelium morphology (HP:0012253)2.78125815
37Increased intramyocellular lipid droplets (HP:0012240)2.77702486
38Poor suck (HP:0002033)2.74455536
39Hepatic necrosis (HP:0002605)2.71255501
40Polyphagia (HP:0002591)2.65454987
41Exertional dyspnea (HP:0002875)2.64274111
42Emotional lability (HP:0000712)2.62228861
43Gait imbalance (HP:0002141)2.59401410
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.56519852
45Respiratory difficulties (HP:0002880)2.55299424
46Supernumerary spleens (HP:0009799)2.54522080
47Abnormality of renal resorption (HP:0011038)2.51504215
48Medial flaring of the eyebrow (HP:0010747)2.50178750
49Microretrognathia (HP:0000308)2.47992181
50Febrile seizures (HP:0002373)2.47453700
51Abnormal pupillary function (HP:0007686)2.47148102
52Pancreatic fibrosis (HP:0100732)2.44713434
53Failure to thrive in infancy (HP:0001531)2.43475552
54Abnormal gallbladder physiology (HP:0012438)2.41704270
55Cholecystitis (HP:0001082)2.41704270
56Opisthotonus (HP:0002179)2.40680708
57Abnormal number of erythroid precursors (HP:0012131)2.38991001
58Atonic seizures (HP:0010819)2.38969704
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37739758
60Abnormal protein N-linked glycosylation (HP:0012347)2.37739758
61Abnormal protein glycosylation (HP:0012346)2.37739758
62Abnormal glycosylation (HP:0012345)2.37739758
63Nephrogenic diabetes insipidus (HP:0009806)2.35950315
64Epileptic encephalopathy (HP:0200134)2.35700130
65Esotropia (HP:0000565)2.35118830
66Lactic acidosis (HP:0003128)2.34578120
67Macrocytic anemia (HP:0001972)2.34502482
68Rimmed vacuoles (HP:0003805)2.34171411
69Pallor (HP:0000980)2.34012503
70Respiratory failure (HP:0002878)2.33832377
71Congenital primary aphakia (HP:0007707)2.31383489
72Cerebral hypomyelination (HP:0006808)2.29511190
73Abnormality of the labia minora (HP:0012880)2.27256675
74Vertebral compression fractures (HP:0002953)2.26525698
75Visual hallucinations (HP:0002367)2.19638814
76Abnormal ciliary motility (HP:0012262)2.18857575
77Cerebral edema (HP:0002181)2.18398590
78Hand muscle atrophy (HP:0009130)2.18108332
79Sleep apnea (HP:0010535)2.17874489
80Prolonged neonatal jaundice (HP:0006579)2.16400231
81True hermaphroditism (HP:0010459)2.15932266
82J-shaped sella turcica (HP:0002680)2.15446627
83Growth hormone excess (HP:0000845)2.12538051
84Hyperventilation (HP:0002883)2.11706925
85Leukodystrophy (HP:0002415)2.10914902
86Cerebellar dysplasia (HP:0007033)2.10862189
87Focal seizures (HP:0007359)2.10385314
88Amblyopia (HP:0000646)2.09885935
89Abnormality of glycolipid metabolism (HP:0010969)2.08060200
90Abnormality of liposaccharide metabolism (HP:0010968)2.08060200
91Abnormality of glycosphingolipid metabolism (HP:0004343)2.08060200
92Abnormal respiratory motile cilium physiology (HP:0012261)2.07607161
93Increased serum lactate (HP:0002151)2.06459631
94Broad distal phalanx of finger (HP:0009836)2.06047772
95Broad-based gait (HP:0002136)2.05060009
96Hypoplastic pelvis (HP:0008839)2.04254768
97Hyperthyroidism (HP:0000836)2.03585599
98Increased muscle lipid content (HP:0009058)2.03375291
99Growth hormone deficiency (HP:0000824)2.02112565
100Myoglobinuria (HP:0002913)2.02101050
101Distal upper limb amyotrophy (HP:0007149)2.01492942
102Upper limb amyotrophy (HP:0009129)2.01492942
103Rhabdomyolysis (HP:0003201)2.00589639
104Lethargy (HP:0001254)1.99308471
105CNS demyelination (HP:0007305)1.97209025
1063-Methylglutaconic aciduria (HP:0003535)1.96185747
107Progressive microcephaly (HP:0000253)1.95630331
108Hyperphosphaturia (HP:0003109)1.93357076
109Adducted thumb (HP:0001181)1.93079639
110Loss of speech (HP:0002371)1.91636506
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91599338
112Rough bone trabeculation (HP:0100670)1.87456712
113Muscle fiber atrophy (HP:0100295)1.87391992
114Genital tract atresia (HP:0001827)1.87145608
115Abnormality of the axillary hair (HP:0100134)1.86842333
116Abnormality of secondary sexual hair (HP:0009888)1.86842333
117Lissencephaly (HP:0001339)1.86386412
118Methylmalonic aciduria (HP:0012120)1.85787376
119Asplenia (HP:0001746)1.85380977
120Vaginal atresia (HP:0000148)1.85283696
121Aplastic anemia (HP:0001915)1.84744100
122Rhinitis (HP:0012384)1.84226248
123Specific learning disability (HP:0001328)1.83848889
124Septo-optic dysplasia (HP:0100842)1.82888482
125Flat capital femoral epiphysis (HP:0003370)1.82538326
126Nephronophthisis (HP:0000090)1.82423372
127Abnormality of fatty-acid metabolism (HP:0004359)1.81940263
128Thyroid-stimulating hormone excess (HP:0002925)1.81877917
129Fasciculations (HP:0002380)1.81569895
130Abnormality of the tricuspid valve (HP:0001702)1.79907704
131X-linked dominant inheritance (HP:0001423)1.79745599
132Multiple enchondromatosis (HP:0005701)1.79045698
133Oligomenorrhea (HP:0000876)1.78589577
134Hyperammonemia (HP:0001987)1.78360005
135Abnormality of midbrain morphology (HP:0002418)1.78193520
136Molar tooth sign on MRI (HP:0002419)1.78193520
137Myopathic facies (HP:0002058)1.77659791
138Narrow nasal bridge (HP:0000446)1.77314657
139Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76816500
140Severe visual impairment (HP:0001141)1.76677640
141Elbow flexion contracture (HP:0002987)1.76595467
142Morphological abnormality of the middle ear (HP:0008609)1.75628016
143Aplasia/Hypoplasia of the spleen (HP:0010451)1.75534257
144Death in infancy (HP:0001522)1.75047500
145Concave nail (HP:0001598)1.74299018
146Hypoventilation (HP:0002791)1.73892320
147Absent/shortened dynein arms (HP:0200106)1.72400710
148Dynein arm defect of respiratory motile cilia (HP:0012255)1.72400710
149Stridor (HP:0010307)1.72262461
150Short tibia (HP:0005736)1.71495266
151Metaphyseal dysplasia (HP:0100255)1.70644736
152Diminished movement (HP:0002374)1.70308851
153Abnormality of the anterior horn cell (HP:0006802)1.70075046
154Degeneration of anterior horn cells (HP:0002398)1.70075046
155Abnormality of dentin (HP:0010299)1.69549241
156Retinal dysplasia (HP:0007973)1.69548173
157Neuroendocrine neoplasm (HP:0100634)1.68548308
158Pancreatic cysts (HP:0001737)1.67793458
159Progressive inability to walk (HP:0002505)1.67750184
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.67738477
161Abnormal number of incisors (HP:0011064)1.67303604
162Secondary amenorrhea (HP:0000869)1.66680064
163Cerebral palsy (HP:0100021)1.66540106
164Agitation (HP:0000713)1.65695816
165Generalized amyotrophy (HP:0003700)1.65488934
166Achilles tendon contracture (HP:0001771)1.63301398
167Abnormality of the umbilical cord (HP:0010881)1.62918393
168Hyperacusis (HP:0010780)1.60317618
169Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.59028005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.98032944
2TESK13.81596950
3BCKDK3.62928354
4CASK3.56448953
5MAP3K123.43132524
6NME13.23794415
7VRK23.18073582
8LIMK13.13364385
9PBK3.06705940
10STK162.80078571
11CDK192.78782162
12MAP2K72.74122229
13MARK12.51737147
14ARAF2.40699398
15CCNB12.29346127
16MAPK132.26866466
17NTRK32.06935883
18CAMKK21.98661048
19ADRBK21.89429227
20BUB11.88200274
21SIK31.88176916
22MAP4K21.85486128
23MAP3K111.84956229
24KDR1.84595581
25MAP3K41.82126382
26ABL21.81211860
27PRKD31.76926173
28MAP3K91.73396083
29GRK71.72667136
30TRIB31.70669545
31ERN11.70253872
32SCYL21.70000013
33MAPKAPK51.68648658
34NTRK21.55088628
35MINK11.54218840
36SRPK11.53533069
37GRK51.51410679
38PDK21.50597515
39MUSK1.38612275
40SIK21.37140443
41DYRK21.36068429
42TNIK1.34065388
43UHMK11.32809619
44PAK61.31643818
45VRK11.30755586
46NME21.30560966
47ADRBK11.27830750
48BRAF1.24324621
49MKNK11.24078338
50NEK11.21386371
51PNCK1.19509985
52MAP2K21.18398212
53CSNK1A1L1.11819783
54PHKG21.11715587
55PHKG11.11715587
56MYLK1.11456585
57DAPK11.09770144
58MAP2K41.06778579
59PRKCG0.97063564
60TAOK20.96932841
61CDK30.94699907
62PIM20.93986246
63RPS6KA50.92585479
64CDC70.91574944
65CDK70.91262830
66MAP2K60.90568697
67ILK0.89424928
68WEE10.88642258
69CAMK40.87526148
70CSNK1G30.86976156
71CAMK2A0.86800760
72CDK80.86784503
73IRAK30.86443680
74EPHA20.86035845
75CAMK10.84874033
76WNK30.84082042
77CAMK2B0.82032863
78DYRK30.81866560
79MAPK40.81710165
80MAPK150.81419917
81TIE10.81118455
82SMG10.80347714
83EPHB20.79894006
84DYRK1A0.79205571
85WNK40.79026942
86CDK50.78010044
87ERBB30.77724170
88RPS6KA40.76998227
89MAPKAPK30.76631335
90PKN20.76561966
91PLK20.73438512
92LRRK20.73277432
93TRIM280.72447755
94RPS6KB20.72288176
95CAMK1D0.70957281
96KSR10.70764728
97PAK40.70274531
98PRKD20.69240988
99PAK10.68935308
100CAMK1G0.68645767
101LATS20.67462788
102CDK11A0.67427797
103MATK0.67165761
104MKNK20.66981883
105AKT20.66334118
106BMPR20.65880219
107PASK0.65744596
108DAPK20.65405022
109CDK180.65218330
110TLK10.64645682
111TBK10.64236111
112TNK20.63775300
113PRKCI0.63148458
114AURKB0.61586676
115RPS6KA20.60287212
116BRSK10.58691765
117ATR0.58270203
118BCR0.58065357
119CDK150.58063629
120CAMK2G0.57878715
121ICK0.57324279
122CDK140.56345867
123CLK10.55626165
124MAPK110.55118325
125PLK10.52266269
126ZAK0.51295810
127MAPK90.51058279
128CAMK2D0.50584152
129CSNK1G20.50326683
130PRKCE0.47359671
131CSNK1G10.47315116
132OXSR10.46395341
133CHEK20.43235126
134SIK10.43117099
135DYRK1B0.42606113
136PRKG20.42001643
137BMPR1B0.41537004
138TTN0.40727841
139DAPK30.39811847
140TGFBR10.39625737
141IRAK20.38096954
142PRKACA0.37863715
143CSNK2A10.37376676
144EEF2K0.36834992
145RPS6KL10.36788251
146RPS6KC10.36788251
147GRK60.36371186
148CSNK2A20.34954353
149CSNK1E0.34870435
150AURKA0.33170966
151PRKD10.29573783
152MAP3K80.28563540
153EIF2AK10.28255880

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.19635899
2Parkinsons disease_Homo sapiens_hsa050124.47474118
3Ribosome_Homo sapiens_hsa030104.16264057
4Alzheimers disease_Homo sapiens_hsa050103.45727500
5Huntingtons disease_Homo sapiens_hsa050163.41711548
6Nicotine addiction_Homo sapiens_hsa050333.19457208
7Sulfur relay system_Homo sapiens_hsa041223.04582653
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.70777626
9Cardiac muscle contraction_Homo sapiens_hsa042602.56548504
10Synaptic vesicle cycle_Homo sapiens_hsa047212.55436637
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.48803133
12Fatty acid elongation_Homo sapiens_hsa000622.39195196
13Collecting duct acid secretion_Homo sapiens_hsa049662.34522487
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21064029
15Folate biosynthesis_Homo sapiens_hsa007902.15522996
16Proteasome_Homo sapiens_hsa030502.07738680
17RNA polymerase_Homo sapiens_hsa030202.02192919
18Biosynthesis of amino acids_Homo sapiens_hsa012302.01679099
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89120994
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78394506
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73909056
22Carbon metabolism_Homo sapiens_hsa012001.72478635
23Pentose phosphate pathway_Homo sapiens_hsa000301.72006697
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69988713
25Olfactory transduction_Homo sapiens_hsa047401.69523385
26GABAergic synapse_Homo sapiens_hsa047271.68866233
27Glutathione metabolism_Homo sapiens_hsa004801.66336165
28Circadian entrainment_Homo sapiens_hsa047131.63160024
29Protein export_Homo sapiens_hsa030601.60976937
30Amphetamine addiction_Homo sapiens_hsa050311.59064076
31Vibrio cholerae infection_Homo sapiens_hsa051101.57321776
32Taste transduction_Homo sapiens_hsa047421.56381067
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54644891
34Serotonergic synapse_Homo sapiens_hsa047261.54537602
35Phototransduction_Homo sapiens_hsa047441.49289149
36Morphine addiction_Homo sapiens_hsa050321.47239689
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45833826
38Glutamatergic synapse_Homo sapiens_hsa047241.40439513
39Cocaine addiction_Homo sapiens_hsa050301.39975035
40Fructose and mannose metabolism_Homo sapiens_hsa000511.37986546
41Dopaminergic synapse_Homo sapiens_hsa047281.35237168
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25775061
43Pyruvate metabolism_Homo sapiens_hsa006201.24886135
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22023404
45Pyrimidine metabolism_Homo sapiens_hsa002401.21450957
46Long-term potentiation_Homo sapiens_hsa047201.19488280
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18826223
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.18590900
49Vitamin B6 metabolism_Homo sapiens_hsa007501.17986036
50Spliceosome_Homo sapiens_hsa030401.16227062
51Long-term depression_Homo sapiens_hsa047301.10256649
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09283794
53Cholinergic synapse_Homo sapiens_hsa047251.07158654
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06347856
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.06134073
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05747053
57Insulin secretion_Homo sapiens_hsa049111.01764128
58Steroid biosynthesis_Homo sapiens_hsa001001.01390614
59Peroxisome_Homo sapiens_hsa041461.00599718
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00566806
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98560667
62Fatty acid metabolism_Homo sapiens_hsa012120.96228457
63Salivary secretion_Homo sapiens_hsa049700.95539462
64Other glycan degradation_Homo sapiens_hsa005110.95068628
65Purine metabolism_Homo sapiens_hsa002300.94166268
66Sulfur metabolism_Homo sapiens_hsa009200.93475186
67Fanconi anemia pathway_Homo sapiens_hsa034600.91882172
68Calcium signaling pathway_Homo sapiens_hsa040200.91456450
69Lysosome_Homo sapiens_hsa041420.91043661
70Alcoholism_Homo sapiens_hsa050340.90569840
71Gap junction_Homo sapiens_hsa045400.90289096
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90087393
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89856661
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88917377
75Oxytocin signaling pathway_Homo sapiens_hsa049210.80935422
76Renin secretion_Homo sapiens_hsa049240.80698651
77Melanogenesis_Homo sapiens_hsa049160.79447505
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78918754
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74419920
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73899089
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73871361
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69720648
83Regulation of autophagy_Homo sapiens_hsa041400.68701281
84Arginine and proline metabolism_Homo sapiens_hsa003300.67309559
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66787061
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65192244
87Rheumatoid arthritis_Homo sapiens_hsa053230.64581575
88GnRH signaling pathway_Homo sapiens_hsa049120.63857914
89Hedgehog signaling pathway_Homo sapiens_hsa043400.62460247
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61502251
91One carbon pool by folate_Homo sapiens_hsa006700.59260282
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57367608
93Gastric acid secretion_Homo sapiens_hsa049710.54959140
94Cell cycle_Homo sapiens_hsa041100.52838163
95Basal transcription factors_Homo sapiens_hsa030220.52123250
96Axon guidance_Homo sapiens_hsa043600.50954165
97Fatty acid degradation_Homo sapiens_hsa000710.48194938
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47793922
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47749682
100RNA degradation_Homo sapiens_hsa030180.47304865
101Wnt signaling pathway_Homo sapiens_hsa043100.47020970
102Oocyte meiosis_Homo sapiens_hsa041140.46055830
103Systemic lupus erythematosus_Homo sapiens_hsa053220.46044686
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44053021
105Circadian rhythm_Homo sapiens_hsa047100.42618462
106Metabolic pathways_Homo sapiens_hsa011000.40780834
107Non-homologous end-joining_Homo sapiens_hsa034500.39608012
108Basal cell carcinoma_Homo sapiens_hsa052170.38694012
109Propanoate metabolism_Homo sapiens_hsa006400.38105406
110beta-Alanine metabolism_Homo sapiens_hsa004100.37626166
111Mismatch repair_Homo sapiens_hsa034300.37114619
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.36754650
113Nucleotide excision repair_Homo sapiens_hsa034200.36707416
114N-Glycan biosynthesis_Homo sapiens_hsa005100.35144897
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34922184
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34392841
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34234470
118RNA transport_Homo sapiens_hsa030130.33372901
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31124387
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.30877548
121DNA replication_Homo sapiens_hsa030300.30811106
122cAMP signaling pathway_Homo sapiens_hsa040240.30773615
123Base excision repair_Homo sapiens_hsa034100.30657751
124Phagosome_Homo sapiens_hsa041450.30471624
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30196515
126Shigellosis_Homo sapiens_hsa051310.29067289
127Glucagon signaling pathway_Homo sapiens_hsa049220.27995609
128Phenylalanine metabolism_Homo sapiens_hsa003600.27739704
129Type I diabetes mellitus_Homo sapiens_hsa049400.27654300
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27590293
131Homologous recombination_Homo sapiens_hsa034400.27370083
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.25559740
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25449134
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24854508
135Arachidonic acid metabolism_Homo sapiens_hsa005900.24562461
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23388018
137African trypanosomiasis_Homo sapiens_hsa051430.23036540
138Tyrosine metabolism_Homo sapiens_hsa003500.22788861
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22457240
140Sphingolipid metabolism_Homo sapiens_hsa006000.22389630
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.22172170
142Estrogen signaling pathway_Homo sapiens_hsa049150.20651128
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.20624503
144ErbB signaling pathway_Homo sapiens_hsa040120.20198954
145mRNA surveillance pathway_Homo sapiens_hsa030150.19934706
146Arginine biosynthesis_Homo sapiens_hsa002200.18703320
147Ras signaling pathway_Homo sapiens_hsa040140.18671302
148AMPK signaling pathway_Homo sapiens_hsa041520.17658550
149Epstein-Barr virus infection_Homo sapiens_hsa051690.17200312
150Thyroid hormone synthesis_Homo sapiens_hsa049180.16922987
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16595369
152Galactose metabolism_Homo sapiens_hsa000520.15382466
153Ether lipid metabolism_Homo sapiens_hsa005650.15261959
154Butanoate metabolism_Homo sapiens_hsa006500.14791962
155Dilated cardiomyopathy_Homo sapiens_hsa054140.14686985
156cGMP-PKG signaling pathway_Homo sapiens_hsa040220.14392577
157Cyanoamino acid metabolism_Homo sapiens_hsa004600.14081460
158Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13123709

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