FMN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanocyte differentiation (GO:0030318)7.67730226
2pigment cell differentiation (GO:0050931)7.66688249
3tyrosine metabolic process (GO:0006570)7.18003215
4phenol-containing compound biosynthetic process (GO:0046189)6.10677516
5melanosome organization (GO:0032438)5.20718817
6pigment granule organization (GO:0048753)4.96579086
7melanin biosynthetic process (GO:0042438)4.81777183
8neuroepithelial cell differentiation (GO:0060563)4.61975479
9endosome to melanosome transport (GO:0035646)4.53927758
10endosome to pigment granule transport (GO:0043485)4.53927758
11detection of light stimulus involved in sensory perception (GO:0050962)4.41934427
12detection of light stimulus involved in visual perception (GO:0050908)4.41934427
13melanin metabolic process (GO:0006582)4.23620538
14secondary metabolite biosynthetic process (GO:0044550)3.99068422
15secondary metabolic process (GO:0019748)3.83607617
16actin filament depolymerization (GO:0030042)3.83150779
17cellular potassium ion homeostasis (GO:0030007)3.67777925
18retinal rod cell development (GO:0046548)3.66375494
19pigmentation (GO:0043473)3.57584243
20cell adhesion mediated by integrin (GO:0033627)3.41477568
21sodium ion export (GO:0071436)3.38275847
22retinal cone cell development (GO:0046549)3.36970240
23regulation of water loss via skin (GO:0033561)3.33956695
24neuron remodeling (GO:0016322)3.33894018
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30542402
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.30542402
27modulation by symbiont of host immune response (GO:0052553)3.30542402
28positive regulation by symbiont of host defense response (GO:0052509)3.30542402
29modulation by symbiont of host defense response (GO:0052031)3.30542402
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30542402
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23775179
32response to host immune response (GO:0052572)3.23775179
33macroautophagy (GO:0016236)3.20566876
34oocyte development (GO:0048599)3.11764886
35regulation of integrin-mediated signaling pathway (GO:2001044)3.09920332
36Golgi to endosome transport (GO:0006895)3.06302346
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05166147
38plasma membrane repair (GO:0001778)2.99667096
39pigment biosynthetic process (GO:0046148)2.97992531
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97537740
41response to host (GO:0075136)2.97537740
42response to host defenses (GO:0052200)2.97537740
43establishment of skin barrier (GO:0061436)2.94476336
44osteoclast differentiation (GO:0030316)2.93281770
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90725355
46chondroitin sulfate catabolic process (GO:0030207)2.90393674
47peripheral nervous system development (GO:0007422)2.89253558
48regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.88098906
49lipoprotein transport (GO:0042953)2.86680987
50positive regulation of cardiac muscle hypertrophy (GO:0010613)2.84581980
51positive regulation of muscle hypertrophy (GO:0014742)2.84581980
52acrosome reaction (GO:0007340)2.83833740
53semaphorin-plexin signaling pathway (GO:0071526)2.82410911
54desmosome organization (GO:0002934)2.73409970
55centrosome duplication (GO:0051298)2.73292008
56basement membrane organization (GO:0071711)2.68816684
57multicellular organism reproduction (GO:0032504)2.68347311
58columnar/cuboidal epithelial cell differentiation (GO:0002065)2.67756201
59regulation of early endosome to late endosome transport (GO:2000641)2.64448325
60proline transport (GO:0015824)2.63637761
61fusion of sperm to egg plasma membrane (GO:0007342)2.63580519
62actin cytoskeleton reorganization (GO:0031532)2.61659179
63eye photoreceptor cell development (GO:0042462)2.60663719
64cellular response to reactive nitrogen species (GO:1902170)2.59604036
65endocardial cushion development (GO:0003197)2.58832316
66long-chain fatty acid biosynthetic process (GO:0042759)2.58443786
67axon extension involved in axon guidance (GO:0048846)2.58014994
68neuron projection extension involved in neuron projection guidance (GO:1902284)2.58014994
69regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57756991
70ketone body metabolic process (GO:1902224)2.57374197
71photoreceptor cell development (GO:0042461)2.57334414
72wound healing, spreading of epidermal cells (GO:0035313)2.57220596
73negative regulation of organelle assembly (GO:1902116)2.57009339
74mitotic G1 DNA damage checkpoint (GO:0031571)2.56627127
75negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56521302
76mitotic G1/S transition checkpoint (GO:0044819)2.55895454
77macrophage activation involved in immune response (GO:0002281)2.54861818
78regulation of clathrin-mediated endocytosis (GO:2000369)2.53229897
79potassium ion homeostasis (GO:0055075)2.53028461
80regulation of integrin activation (GO:0033623)2.50208554
81positive regulation of p38MAPK cascade (GO:1900745)2.49756861
82negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.49505523
83retrograde transport, vesicle recycling within Golgi (GO:0000301)2.48586766
84negative regulation of macroautophagy (GO:0016242)2.48208815
85relaxation of cardiac muscle (GO:0055119)2.47101983
86lipid translocation (GO:0034204)2.46560282
87phospholipid translocation (GO:0045332)2.46560282
88intestinal epithelial cell development (GO:0060576)2.45372427
89rhodopsin mediated signaling pathway (GO:0016056)2.43822175
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.43298512
91Rac protein signal transduction (GO:0016601)2.43131692
92regulation of interferon-beta biosynthetic process (GO:0045357)2.42443216
93cellular response to nitric oxide (GO:0071732)2.41004554
94phospholipid homeostasis (GO:0055091)2.39481814
95cell communication involved in cardiac conduction (GO:0086065)2.38918331
96membrane protein ectodomain proteolysis (GO:0006509)2.37837797
97positive regulation of heat generation (GO:0031652)2.37382061
98apoptotic cell clearance (GO:0043277)2.37378067
99regulation of voltage-gated calcium channel activity (GO:1901385)2.37128345
100regulation of protein polyubiquitination (GO:1902914)2.36760739
101cilium or flagellum-dependent cell motility (GO:0001539)2.36280454
102regulation of rhodopsin mediated signaling pathway (GO:0022400)2.35862821
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35849516
104behavioral response to ethanol (GO:0048149)2.35653373
105I-kappaB phosphorylation (GO:0007252)2.35186350
106cellular response to thyroid hormone stimulus (GO:0097067)2.34794772
107cellular response to ATP (GO:0071318)2.34596539
108G1 DNA damage checkpoint (GO:0044783)2.33282348
109phenol-containing compound metabolic process (GO:0018958)2.33235330
110establishment of protein localization to Golgi (GO:0072600)2.33101816
111protein targeting to Golgi (GO:0000042)2.32734057
112cerebellar Purkinje cell differentiation (GO:0021702)2.32138880
113fibroblast migration (GO:0010761)2.32073405
114relaxation of smooth muscle (GO:0044557)2.31769956
115sperm motility (GO:0030317)2.30987504
116synaptic vesicle endocytosis (GO:0048488)2.30259085
117regulation of acrosome reaction (GO:0060046)2.27298420
118positive regulation of neuroblast proliferation (GO:0002052)2.27191275
119cell communication by electrical coupling (GO:0010644)2.26970714
120regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.26851268
121developmental pigmentation (GO:0048066)2.26634609
122regulation of female gonad development (GO:2000194)2.26022790
123regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.25887402
124negative regulation of inclusion body assembly (GO:0090084)2.25130949
125vitamin transmembrane transport (GO:0035461)2.24705751
126pigment metabolic process (GO:0042440)2.24456402
127pigment granule transport (GO:0051904)2.23165480
128urinary tract smooth muscle contraction (GO:0014848)2.23129192
129natural killer cell mediated cytotoxicity (GO:0042267)2.23054938
130natural killer cell mediated immunity (GO:0002228)2.23054938
131detection of visible light (GO:0009584)2.21678180
132chondroitin sulfate biosynthetic process (GO:0030206)2.21454302
133early endosome to late endosome transport (GO:0045022)2.20976435
134neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.20944202
135positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.20728323
136cardiac conduction (GO:0061337)2.20656613
137establishment of pigment granule localization (GO:0051905)2.20518486
138melanosome transport (GO:0032402)2.20408600
139vesicle transport along microtubule (GO:0047496)2.20222002
140endosome organization (GO:0007032)2.20032620
141cellular response to ethanol (GO:0071361)2.19935273
142dermatan sulfate biosynthetic process (GO:0030208)2.19917656
143multicellular organismal water homeostasis (GO:0050891)2.19776303
144regulation of alkaline phosphatase activity (GO:0010692)2.19762710
145glomerular epithelial cell development (GO:0072310)2.19483875
146pigment granule localization (GO:0051875)2.18833446
147positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.18777185
148positive regulation of cellular amide metabolic process (GO:0034250)2.18776756
149regulation of mononuclear cell migration (GO:0071675)2.18622309
150regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.18597138
151axonemal dynein complex assembly (GO:0070286)2.18538274
152regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.18299152
153establishment of melanosome localization (GO:0032401)2.17766601
154reproduction (GO:0000003)2.17623785
155virion attachment to host cell (GO:0019062)2.16819908
156adhesion of symbiont to host cell (GO:0044650)2.16819908
157membrane depolarization during action potential (GO:0086010)2.16455976
158melanosome localization (GO:0032400)2.16240675
159heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.16034406
160keratan sulfate catabolic process (GO:0042340)2.15665837
161protein localization to endosome (GO:0036010)2.15362543
162glial cell migration (GO:0008347)2.15110631
163positive regulation vascular endothelial growth factor production (GO:0010575)2.14715201
164angiogenesis involved in wound healing (GO:0060055)2.14701401
165aromatic amino acid family metabolic process (GO:0009072)2.14674357
166regulation of short-term neuronal synaptic plasticity (GO:0048172)2.14625799
167positive regulation of receptor recycling (GO:0001921)2.14625226
168glomerular visceral epithelial cell development (GO:0072015)2.12333806
169detection of light stimulus (GO:0009583)2.12192716
170smooth muscle tissue development (GO:0048745)2.11089080
171calcium ion-dependent exocytosis (GO:0017156)2.09941315
172protein-chromophore linkage (GO:0018298)2.09860443
173regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.09835224
174regulation of bile acid biosynthetic process (GO:0070857)2.09817887
175enteric nervous system development (GO:0048484)2.09556518
176regulation of chemokine-mediated signaling pathway (GO:0070099)2.08472825
177cellular sodium ion homeostasis (GO:0006883)2.07729711
178detection of temperature stimulus involved in sensory perception (GO:0050961)2.06855308
179detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.06855308
180detection of temperature stimulus (GO:0016048)2.06754485
181sequestering of extracellular ligand from receptor (GO:0035581)2.04588327
182neurofilament cytoskeleton organization (GO:0060052)2.03860110
183regulation of membrane protein ectodomain proteolysis (GO:0051043)2.03673328
184cellular response to interferon-alpha (GO:0035457)2.03646591
185peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.03447775
186G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.02179463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.60434613
2* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45247300
3CDX2_19796622_ChIP-Seq_MESCs_Mouse2.39403883
4GBX2_23144817_ChIP-Seq_PC3_Human2.36910067
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00885916
6SMAD_19615063_ChIP-ChIP_OVARY_Human1.90932816
7ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90055843
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86822050
9TRIM28_21343339_ChIP-Seq_HEK293_Human1.71523192
10TP63_17297297_ChIP-ChIP_HaCaT_Human1.70297637
11GATA1_22025678_ChIP-Seq_K562_Human1.65323548
12DROSHA_22980978_ChIP-Seq_HELA_Human1.65107176
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64804774
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64185030
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58696623
16* MITF_21258399_ChIP-Seq_MELANOMA_Human1.58047117
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.57432153
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56378841
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.55472471
20* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55131573
21CJUN_26792858_Chip-Seq_BT549_Human1.51306028
22AHR_22903824_ChIP-Seq_MCF-7_Human1.50692464
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.49449197
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47978809
25SMAD4_21799915_ChIP-Seq_A2780_Human1.47709183
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.47373791
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47360913
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47300580
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47300580
30VDR_24787735_ChIP-Seq_THP-1_Human1.41379566
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.37777484
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.36369254
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36012350
34TP53_16413492_ChIP-PET_HCT116_Human1.35063575
35AR_21572438_ChIP-Seq_LNCaP_Human1.34951812
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34340138
37BRD4_25478319_ChIP-Seq_HGPS_Human1.33922480
38* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32657910
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.27612530
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27078624
41* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26828812
42EZH2_22144423_ChIP-Seq_EOC_Human1.25576651
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22594742
44NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21982518
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19491912
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19036534
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18780340
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18399497
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17990575
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17829115
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16428371
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15157905
53STAT3_23295773_ChIP-Seq_U87_Human1.15136504
54IGF1R_20145208_ChIP-Seq_DFB_Human1.14886869
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.14113335
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13013472
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12981614
58* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12142118
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12031923
60CBP_20019798_ChIP-Seq_JUKART_Human1.12031923
61* SMAD3_21741376_ChIP-Seq_HESCs_Human1.11712137
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.11524532
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.11524532
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11121125
65* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11026562
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10968021
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.10815146
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10723242
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10225865
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10185616
71* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10158295
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10022522
73* AR_25329375_ChIP-Seq_VCAP_Human1.09699580
74BCAT_22108803_ChIP-Seq_LS180_Human1.09505908
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08979366
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08979366
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08737122
78JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08112257
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08094412
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08044864
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.07213708
82PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06351750
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06321657
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05895201
85* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05666774
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05562209
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05426914
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03394370
89TP53_18474530_ChIP-ChIP_U2OS_Human1.03354574
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02585942
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.02258766
92CDX2_22108803_ChIP-Seq_LS180_Human1.02257909
93GF1_26923725_Chip-Seq_HPCs_Mouse1.01648495
94* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01553237
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00913474
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00866669
97KLF5_25053715_ChIP-Seq_YYC3_Human0.99825125
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99643968
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98782354
100TCF4_23295773_ChIP-Seq_U87_Human0.98777115
101SOX2_21211035_ChIP-Seq_LN229_Gbm0.97632963
102* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97540922
103ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97238282
104* P300_19829295_ChIP-Seq_ESCs_Human0.97211776
105* FOXO3_23340844_ChIP-Seq_DLD1_Human0.97113859
106SMAD3_21741376_ChIP-Seq_EPCs_Human0.97080207
107TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96795446
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96330325
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95337654
110TCF4_22108803_ChIP-Seq_LS180_Human0.94602409
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94412371
112RUNX_20019798_ChIP-Seq_JUKART_Human0.94286173
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.94082807
114RXR_22108803_ChIP-Seq_LS180_Human0.93580184
115CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93372909
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92776853
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92679484
118* TP63_23658742_ChIP-Seq_EP156T_Human0.92554988
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.92396122
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92148601
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.92053975
122ER_23166858_ChIP-Seq_MCF-7_Human0.91959028
123SPI1_23127762_ChIP-Seq_K562_Human0.91881140
124SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91662860
125EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90704396
126RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90704396
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90562275
128SOX2_20726797_ChIP-Seq_SW620_Human0.88605037
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88344616
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88250127
131* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88186927
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88000061
133* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87769653
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87506745
135AR_19668381_ChIP-Seq_PC3_Human0.87503918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.48686010
2MP0003136_yellow_coat_color6.02430589
3MP0005075_abnormal_melanosome_morpholog4.47472378
4MP0000372_irregular_coat_pigmentation4.03582063
5MP0005551_abnormal_eye_electrophysiolog3.31702671
6MP0005257_abnormal_intraocular_pressure3.30305240
7MP0005171_absent_coat_pigmentation3.11495909
8MP0002090_abnormal_vision2.99452050
9MP0003950_abnormal_plasma_membrane2.77065676
10MP0005058_abnormal_lysosome_morphology2.73104154
11MP0003172_abnormal_lysosome_physiology2.59075855
12MP0000371_diluted_coat_color2.42583412
13MP0003011_delayed_dark_adaptation2.35601090
14MP0001324_abnormal_eye_pigmentation2.34347758
15MP0008438_abnormal_cutaneous_collagen2.26416157
16MP0003045_fibrosis2.25824836
17MP0003705_abnormal_hypodermis_morpholog2.24545151
18MP0003183_abnormal_peptide_metabolism2.23967299
19MP0005409_darkened_coat_color2.16610962
20MP0000015_abnormal_ear_pigmentation1.82087299
21MP0010386_abnormal_urinary_bladder1.81192739
22MP0005253_abnormal_eye_physiology1.77421410
23MP0005408_hypopigmentation1.75085193
24MP0008004_abnormal_stomach_pH1.69004081
25MP0005275_abnormal_skin_tensile1.64581118
26MP0003300_gastrointestinal_ulcer1.59650589
27MP0004858_abnormal_nervous_system1.56207044
28MP0003091_abnormal_cell_migration1.55800367
29MP0001958_emphysema1.54619931
30MP0003566_abnormal_cell_adhesion1.54045943
31MP0004084_abnormal_cardiac_muscle1.53395558
32MP0004510_myositis1.47361230
33MP0005197_abnormal_uvea_morphology1.46720166
34MP0002254_reproductive_system_inflammat1.41705545
35MP0005174_abnormal_tail_pigmentation1.39582713
36MP0003252_abnormal_bile_duct1.35789513
37MP0000751_myopathy1.34906445
38MP0008775_abnormal_heart_ventricle1.30737474
39MP0009046_muscle_twitch1.30688297
40MP0004233_abnormal_muscle_weight1.28965220
41MP0002938_white_spotting1.27543079
42MP0002735_abnormal_chemical_nociception1.26511488
43MP0003879_abnormal_hair_cell1.22602824
44MP0003279_aneurysm1.20810299
45MP0000604_amyloidosis1.18999595
46MP0010352_gastrointestinal_tract_polyps1.17874206
47MP0001299_abnormal_eye_distance/1.16307599
48MP0005195_abnormal_posterior_eye1.15018743
49MP0005248_abnormal_Harderian_gland1.11544158
50MP0005360_urolithiasis1.08343690
51MP0000749_muscle_degeneration1.04774809
52MP0006072_abnormal_retinal_apoptosis1.03371368
53MP0003436_decreased_susceptibility_to1.03314801
54MP0002229_neurodegeneration1.02242426
55MP0002928_abnormal_bile_duct1.02193205
56MP0004036_abnormal_muscle_relaxation1.01368414
57MP0005503_abnormal_tendon_morphology1.00671739
58MP0002998_abnormal_bone_remodeling0.99734987
59MP0005377_hearing/vestibular/ear_phenot0.97483167
60MP0003878_abnormal_ear_physiology0.97483167
61MP0002168_other_aberrant_phenotype0.97309078
62MP0002332_abnormal_exercise_endurance0.96417337
63MP0004947_skin_inflammation0.96322223
64MP0005623_abnormal_meninges_morphology0.95757731
65MP0002972_abnormal_cardiac_muscle0.92772597
66MP0004215_abnormal_myocardial_fiber0.91394932
67MP0005023_abnormal_wound_healing0.91392612
68MP0005410_abnormal_fertilization0.89406730
69MP0002075_abnormal_coat/hair_pigmentati0.89388095
70MP0003303_peritoneal_inflammation0.88645641
71MP0001968_abnormal_touch/_nociception0.87116082
72MP0001533_abnormal_skeleton_physiology0.85964622
73MP0004381_abnormal_hair_follicle0.81698531
74MP0002419_abnormal_innate_immunity0.80735993
75MP0004130_abnormal_muscle_cell0.79093113
76MP0002177_abnormal_outer_ear0.75986414
77MP0009780_abnormal_chondrocyte_physiolo0.74946642
78MP0000538_abnormal_urinary_bladder0.74005914
79MP0002877_abnormal_melanocyte_morpholog0.73001518
80MP0003191_abnormal_cellular_cholesterol0.72835720
81MP0001986_abnormal_taste_sensitivity0.72790614
82MP0004270_analgesia0.71697071
83MP0009840_abnormal_foam_cell0.71526279
84MP0010234_abnormal_vibrissa_follicle0.70401053
85MP0000733_abnormal_muscle_development0.69275458
86MP0002734_abnormal_mechanical_nocicepti0.68825824
87MP0001984_abnormal_olfaction0.68592001
88MP0003646_muscle_fatigue0.67455344
89MP0010678_abnormal_skin_adnexa0.67401580
90MP0004043_abnormal_pH_regulation0.66834511
91MP0004087_abnormal_muscle_fiber0.66141946
92MP0000427_abnormal_hair_cycle0.64771164
93MP0010307_abnormal_tumor_latency0.64319721
94MP0002089_abnormal_postnatal_growth/wei0.64216153
95MP0001186_pigmentation_phenotype0.60933901
96MP0002166_altered_tumor_susceptibility0.60394950
97MP0009697_abnormal_copulation0.60256822
98MP0004484_altered_response_of0.60224384
99MP0005076_abnormal_cell_differentiation0.59722990
100MP0005620_abnormal_muscle_contractility0.59672030
101MP0002060_abnormal_skin_morphology0.58485293
102MP0002095_abnormal_skin_pigmentation0.57729817
103MP0002909_abnormal_adrenal_gland0.56159881
104MP0002295_abnormal_pulmonary_circulatio0.55092363
105MP0009764_decreased_sensitivity_to0.54621606
106MP0003448_altered_tumor_morphology0.54517515
107MP0003634_abnormal_glial_cell0.53820610
108MP0003453_abnormal_keratinocyte_physiol0.53688095
109MP0003828_pulmonary_edema0.53212806
110MP0000367_abnormal_coat/_hair0.52885105
111MP0002796_impaired_skin_barrier0.51917332
112MP0000920_abnormal_myelination0.49954402
113MP0009384_cardiac_valve_regurgitation0.48468773
114MP0002638_abnormal_pupillary_reflex0.44732038
115MP0005379_endocrine/exocrine_gland_phen0.44519800
116MP0006054_spinal_hemorrhage0.41253838
117MP0003632_abnormal_nervous_system0.40570139
118MP0000377_abnormal_hair_follicle0.39716705
119MP0002896_abnormal_bone_mineralization0.39555709
120MP0003718_maternal_effect0.38262938
121MP0002102_abnormal_ear_morphology0.38048327
122MP0005165_increased_susceptibility_to0.37883910
123MP0005395_other_phenotype0.33843677
124MP0005164_abnormal_response_to0.32829153
125MP0004885_abnormal_endolymph0.32697664
126MP0005451_abnormal_body_composition0.32387807
127MP0003195_calcinosis0.30290819
128MP0001851_eye_inflammation0.27099623
129MP0006082_CNS_inflammation0.26533651
130MP0004272_abnormal_basement_membrane0.25098319
131MP0003329_amyloid_beta_deposits0.24148024
132MP0000627_abnormal_mammary_gland0.23991404
133MP0003795_abnormal_bone_structure0.23243183
134MP0000465_gastrointestinal_hemorrhage0.22981669
135MP0001664_abnormal_digestion0.22377350
136MP0001756_abnormal_urination0.21823545
137MP0005595_abnormal_vascular_smooth0.21354959
138MP0005193_abnormal_anterior_eye0.20859955
139MP0004264_abnormal_extraembryonic_tissu0.20843220
140MP0006138_congestive_heart_failure0.20296215
141MP0008569_lethality_at_weaning0.19595436

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.75631298
2White forelock (HP:0002211)7.53680572
3Patchy hypopigmentation of hair (HP:0011365)6.79942198
4Hypopigmentation of the fundus (HP:0007894)5.42665514
5Generalized hypopigmentation of hair (HP:0011358)4.57362592
6Hypoplasia of the iris (HP:0007676)4.00989600
7Central scotoma (HP:0000603)3.95712701
8Abnormality of macular pigmentation (HP:0008002)3.95109548
9Abnormality of liposaccharide metabolism (HP:0010968)3.94550555
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.94550555
11Abnormality of glycolipid metabolism (HP:0010969)3.94550555
12Aplasia/Hypoplasia of the macula (HP:0008059)3.91941482
13Heterochromia iridis (HP:0001100)3.74631262
14Abnormal auditory evoked potentials (HP:0006958)3.73018759
15Aplasia/Hypoplasia affecting the retina (HP:0008061)3.66231882
16Dyschromatopsia (HP:0007641)3.56009280
17Congenital sensorineural hearing impairment (HP:0008527)3.50568891
18Premature graying of hair (HP:0002216)3.44136644
19Bilateral sensorineural hearing impairment (HP:0008619)3.29034458
20Freckling (HP:0001480)3.26336778
21Pigmentary retinal degeneration (HP:0001146)3.13931936
22Hypoplastic ischia (HP:0003175)3.09133140
23Generalized hypopigmentation (HP:0007513)2.95633365
24Hypoplasia of the fovea (HP:0007750)2.94262929
25Aplasia/Hypoplasia of the fovea (HP:0008060)2.94262929
26Decreased central vision (HP:0007663)2.92449386
27Abnormality of the ischium (HP:0003174)2.90944504
28Scotoma (HP:0000575)2.86010658
29Hydroxyprolinuria (HP:0003080)2.75972501
30Abnormality of proline metabolism (HP:0010907)2.75972501
31Submucous cleft hard palate (HP:0000176)2.75229243
32Increased cerebral lipofuscin (HP:0011813)2.75174454
33Febrile seizures (HP:0002373)2.70481348
34Bony spicule pigmentary retinopathy (HP:0007737)2.66498558
35Ocular albinism (HP:0001107)2.59953372
36Thick nail (HP:0001805)2.58178776
37Axonal loss (HP:0003447)2.57608439
38Blue irides (HP:0000635)2.49594207
39Aortic aneurysm (HP:0004942)2.49265796
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.45597419
41Cone-rod dystrophy (HP:0000548)2.41785951
42Premature rupture of membranes (HP:0001788)2.39114918
43Long toe (HP:0010511)2.38809031
44Chorioretinal atrophy (HP:0000533)2.37528632
45Absent frontal sinuses (HP:0002688)2.36507996
46Abnormality of the fovea (HP:0000493)2.36050816
47Cutaneous melanoma (HP:0012056)2.33736146
48Progressive visual loss (HP:0000529)2.33005829
49Recurrent bacterial skin infections (HP:0005406)2.32368808
50Distal lower limb muscle weakness (HP:0009053)2.29642042
51Vitreoretinal degeneration (HP:0000655)2.28852031
52Right ventricular cardiomyopathy (HP:0011663)2.26087457
53Keratoconus (HP:0000563)2.24469196
54Increased corneal curvature (HP:0100692)2.24469196
55Loss of speech (HP:0002371)2.24164076
56Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.23971831
57Macular degeneration (HP:0000608)2.23860947
58J-shaped sella turcica (HP:0002680)2.23424089
59Distal lower limb amyotrophy (HP:0008944)2.22065549
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20107558
61Abnormality of polysaccharide metabolism (HP:0011012)2.20107558
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20107558
63Vascular tortuosity (HP:0004948)2.18692717
64Iris hypopigmentation (HP:0007730)2.18608011
65Choroideremia (HP:0001139)2.15817102
66Urethral obstruction (HP:0000796)2.15542041
67Recurrent abscess formation (HP:0002722)2.15419315
68Gingivitis (HP:0000230)2.12637035
69Severe visual impairment (HP:0001141)2.12170755
70Abnormal rod and cone electroretinograms (HP:0008323)2.12017841
71Cupped ribs (HP:0000887)2.11923850
72Flat acetabular roof (HP:0003180)2.10962284
73Increased connective tissue (HP:0009025)2.08948052
74Prolonged QT interval (HP:0001657)2.08137207
75Arterial tortuosity (HP:0005116)2.08112652
76Hand muscle atrophy (HP:0009130)2.07845354
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.07691804
78Osteolytic defects of the hand bones (HP:0009699)2.07691804
79Underdeveloped nasal alae (HP:0000430)2.05848536
80Protuberant abdomen (HP:0001538)2.05348447
81Cerebral inclusion bodies (HP:0100314)2.04481986
82Hyporeflexia of lower limbs (HP:0002600)2.03675595
83Peripheral hypomyelination (HP:0007182)2.00971797
84Atrophic scars (HP:0001075)1.99875582
85Lip pit (HP:0100267)1.97839858
86Prostate neoplasm (HP:0100787)1.97558650
87Hyperkalemia (HP:0002153)1.97259143
88Photophobia (HP:0000613)1.97082102
89Distal upper limb amyotrophy (HP:0007149)1.96625056
90Upper limb amyotrophy (HP:0009129)1.96625056
91Genetic anticipation (HP:0003743)1.96104978
92Dysostosis multiplex (HP:0000943)1.95926630
93Urinary glycosaminoglycan excretion (HP:0003541)1.95054492
94Mucopolysacchariduria (HP:0008155)1.95054492
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94070717
96Ulnar claw (HP:0001178)1.93527122
97Neurofibrillary tangles (HP:0002185)1.93081315
98Albinism (HP:0001022)1.93031073
99Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92190719
100Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.91781672
101Synophrys (HP:0000664)1.91355948
102Syncope (HP:0001279)1.91040235
103Eczematoid dermatitis (HP:0000976)1.91006571
104Vacuolated lymphocytes (HP:0001922)1.88739036
105Abnormality of vision evoked potentials (HP:0000649)1.88636225
106Epiphyseal dysplasia (HP:0002656)1.87852179
107Spinal muscular atrophy (HP:0007269)1.87709271
108Retinal atrophy (HP:0001105)1.86639222
109Lower limb amyotrophy (HP:0007210)1.85361393
110Aortic dissection (HP:0002647)1.84407313
111Progressive cerebellar ataxia (HP:0002073)1.83854756
112Abolished electroretinogram (ERG) (HP:0000550)1.83265169
113Mitral stenosis (HP:0001718)1.81124450
114Epileptic encephalopathy (HP:0200134)1.80430422
115Vertebral compression fractures (HP:0002953)1.77651288
116Frequent falls (HP:0002359)1.77342503
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76347985
118Abnormality of the distal phalanges of the toes (HP:0010182)1.75947204
119Asymmetric septal hypertrophy (HP:0001670)1.75938474
120Cervical subluxation (HP:0003308)1.75762627
121Absence seizures (HP:0002121)1.74222952
122Cerebral aneurysm (HP:0004944)1.74041947
123Atrial fibrillation (HP:0005110)1.73074408
124Progressive sensorineural hearing impairment (HP:0000408)1.71562580
125Premature loss of primary teeth (HP:0006323)1.70332675
126Severe Myopia (HP:0011003)1.70282157
127Ovoid vertebral bodies (HP:0003300)1.70109363
128Myocardial infarction (HP:0001658)1.70090125
129Autoimmune thrombocytopenia (HP:0001973)1.69353603
130Akinesia (HP:0002304)1.69233113
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69146332
132Deformed sella turcica (HP:0002681)1.58316601
133Abnormal glucose tolerance (HP:0001952)1.57904570
134Protrusio acetabuli (HP:0003179)1.57899269
135Neonatal short-limb short stature (HP:0008921)1.56126145
136Glucose intolerance (HP:0000833)1.52043786
137Decreased motor nerve conduction velocity (HP:0003431)1.49442228
138Paraparesis (HP:0002385)1.49343187
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.49328732
140Spastic paraparesis (HP:0002313)1.47469711
141Spondylolisthesis (HP:0003302)1.46505369
142Femoral bowing (HP:0002980)1.46312911
143Germ cell neoplasia (HP:0100728)1.45002333
144Interstitial pulmonary disease (HP:0006530)1.42413118
145Absent/shortened dynein arms (HP:0200106)1.42042980
146Dynein arm defect of respiratory motile cilia (HP:0012255)1.42042980
147Upper limb muscle weakness (HP:0003484)1.41633373
148Rhinitis (HP:0012384)1.38042774
149Action tremor (HP:0002345)1.37524715
150Subacute progressive viral hepatitis (HP:0006572)1.36872979
151Supranuclear gaze palsy (HP:0000605)1.36519951
152Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.36412930
153Wormian bones (HP:0002645)1.35867067
154Abnormal ciliary motility (HP:0012262)1.34149480
155Cranial hyperostosis (HP:0004437)1.31535722
156Diminished movement (HP:0002374)1.30084824
157Abnormality of the sella turcica (HP:0002679)1.29800604
158Decreased circulating renin level (HP:0003351)1.29714258
159Global brain atrophy (HP:0002283)1.29546202
160Infertility (HP:0000789)1.29042448
161Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.28891977
162Tubulointerstitial nephritis (HP:0001970)1.27641078
163Hypokinesia (HP:0002375)1.26961665
164Large for gestational age (HP:0001520)1.25369677
165Abnormal respiratory motile cilium physiology (HP:0012261)1.24269855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.46482024
2WEE13.65865466
3TTN2.77020576
4EPHA32.61079099
5DDR22.54629767
6LMTK22.13852614
7CAMK1D2.05234513
8RIPK12.03988738
9FRK2.03472004
10CAMK1G1.95467487
11RIPK41.94154179
12MET1.90642626
13ACVR1B1.89594231
14MAP3K141.79395573
15STK381.71179878
16ICK1.67227067
17ERBB41.65762006
18LATS11.65715498
19MAP3K131.65006744
20NTRK11.63069119
21JAK11.61960727
22TAOK31.57027710
23MAPKAPK31.54374656
24NEK61.53989409
25TRPM71.42450196
26FER1.38436082
27PIK3CA1.37822486
28PAK41.37735324
29TYK21.37573392
30MARK31.34549872
31WNK11.28011799
32BMX1.26185571
33DMPK1.22583650
34PAK61.22336197
35TBK11.19565995
36KSR21.19447281
37PDPK11.18300341
38INSRR1.18129899
39GSK3A1.17875264
40NEK91.14433760
41MAP3K21.14317673
42DAPK21.14297113
43MAP3K91.13672999
44NUAK11.08474034
45ZAP701.07204779
46CDK121.06839457
47CAMKK11.06702351
48AKT31.03947582
49BMPR21.02280374
50SGK30.99559788
51PLK20.96769198
52NEK10.95151819
53PTK20.95016842
54SGK20.94677165
55PHKG20.91886873
56PHKG10.91886873
57CAMKK20.90391361
58SIK20.88839470
59PAK30.88363302
60PTK60.86495058
61PRKAA20.86322379
62MUSK0.85768848
63MELK0.85351325
64PTK2B0.84603700
65PRKG20.84522103
66RET0.81641211
67PDK20.81518429
68WNK40.81280420
69TYRO30.80264881
70STK38L0.79062100
71CSNK1A1L0.78107583
72GRK70.77354235
73PRKCH0.77029033
74ERBB20.75396651
75MYLK0.74459778
76PRKD30.74244234
77MAP3K40.72774653
78SIK10.72657170
79STK30.72552259
80TESK10.72501520
81FGFR30.71883493
82PRKCE0.71436792
83LATS20.71037925
84PRKD10.70319825
85SGK10.70292096
86ABL20.69719977
87MOS0.69686772
88PRKAA10.69613342
89CDK70.69181109
90ERN10.66921802
91KIT0.66467735
92IRAK30.66442127
93MAPK110.64792590
94TRIB30.63822435
95PNCK0.63175867
96PKN20.62391113
97SGK4940.60580873
98SGK2230.60580873
99IKBKE0.60476572
100PRKD20.60347933
101BMPR1B0.59267398
102FGFR20.58841148
103MAP3K70.57989097
104CAMK2D0.57900387
105RPS6KA20.56656591
106EPHB10.55582520
107GRK10.54902725
108PBK0.54635263
109CHUK0.54369371
110SCYL20.54325385
111CDK30.53998745
112JAK30.53911424
113ROCK10.53862032
114MTOR0.53854201
115MINK10.53092501
116MAP3K50.52864546
117CDC42BPA0.52268323
118MAP2K10.51087209
119PDGFRB0.51071220
120CDK60.50981002
121MATK0.50349133
122EGFR0.49139784
123MAP3K10.48737467
124ADRBK10.48634269
125SRC0.48374888
126HCK0.48136706
127PDGFRA0.47444797
128PIK3CG0.47363918
129CSNK1G20.45731129
130YES10.45535936
131PDK10.44654452
132GRK50.44423116
133TGFBR20.44240947
134MAPK150.43967967
135MAPK70.43711414
136FYN0.42345546
137MAP3K30.41417135
138IKBKB0.40022881
139JAK20.39790942
140AKT20.39548835
141STK390.34714845
142CSNK1G10.34541829
143PAK20.33381431
144FGFR10.33362473
145CSNK1G30.32009945
146MAPK10.31547304

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.79813851
2Synaptic vesicle cycle_Homo sapiens_hsa047212.04792640
3Mineral absorption_Homo sapiens_hsa049781.78066872
4Melanogenesis_Homo sapiens_hsa049161.69909384
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64322459
6Fatty acid biosynthesis_Homo sapiens_hsa000611.62917589
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62700067
8Collecting duct acid secretion_Homo sapiens_hsa049661.60051376
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.50014349
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47701421
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45717708
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45657231
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45218445
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43300369
15Dilated cardiomyopathy_Homo sapiens_hsa054141.41088664
16Caffeine metabolism_Homo sapiens_hsa002321.35519446
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27201882
18Lysosome_Homo sapiens_hsa041421.23366839
19Type II diabetes mellitus_Homo sapiens_hsa049301.22084479
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20795627
21Prostate cancer_Homo sapiens_hsa052151.18594809
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17534796
23Salivary secretion_Homo sapiens_hsa049701.15115336
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.14671219
25Olfactory transduction_Homo sapiens_hsa047401.14135529
26Osteoclast differentiation_Homo sapiens_hsa043801.12546896
27Thyroid cancer_Homo sapiens_hsa052161.08944956
28Small cell lung cancer_Homo sapiens_hsa052221.08574436
29Phagosome_Homo sapiens_hsa041451.08509383
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06318447
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02684000
32Rheumatoid arthritis_Homo sapiens_hsa053231.02216698
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01829304
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99951026
35Dorso-ventral axis formation_Homo sapiens_hsa043200.97298529
36Tuberculosis_Homo sapiens_hsa051520.97225773
37ECM-receptor interaction_Homo sapiens_hsa045120.97125413
38Amoebiasis_Homo sapiens_hsa051460.96628096
39Insulin secretion_Homo sapiens_hsa049110.94526146
40Nicotine addiction_Homo sapiens_hsa050330.91844046
41Bile secretion_Homo sapiens_hsa049760.90866021
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90789190
43Malaria_Homo sapiens_hsa051440.90184496
44Protein digestion and absorption_Homo sapiens_hsa049740.88232288
45Estrogen signaling pathway_Homo sapiens_hsa049150.88180822
46TNF signaling pathway_Homo sapiens_hsa046680.88001735
47Renin secretion_Homo sapiens_hsa049240.87878401
48GABAergic synapse_Homo sapiens_hsa047270.86781042
49Cholinergic synapse_Homo sapiens_hsa047250.86378791
50Renin-angiotensin system_Homo sapiens_hsa046140.85932180
51Leishmaniasis_Homo sapiens_hsa051400.85606602
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85230633
53Staphylococcus aureus infection_Homo sapiens_hsa051500.85049853
54Inositol phosphate metabolism_Homo sapiens_hsa005620.84649368
55Starch and sucrose metabolism_Homo sapiens_hsa005000.83351654
56Vibrio cholerae infection_Homo sapiens_hsa051100.83003925
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82562203
58mTOR signaling pathway_Homo sapiens_hsa041500.82321543
59Oxytocin signaling pathway_Homo sapiens_hsa049210.80918961
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78543222
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78145433
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77259759
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77037641
64Salmonella infection_Homo sapiens_hsa051320.76965541
65Focal adhesion_Homo sapiens_hsa045100.76955655
66Glioma_Homo sapiens_hsa052140.76894777
67Endometrial cancer_Homo sapiens_hsa052130.76693717
68Circadian entrainment_Homo sapiens_hsa047130.76534229
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76139859
70Ovarian steroidogenesis_Homo sapiens_hsa049130.75744060
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.75409645
72Circadian rhythm_Homo sapiens_hsa047100.75339321
73Prolactin signaling pathway_Homo sapiens_hsa049170.74794643
74Morphine addiction_Homo sapiens_hsa050320.74788583
75Gastric acid secretion_Homo sapiens_hsa049710.74387588
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74367501
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74339061
78MicroRNAs in cancer_Homo sapiens_hsa052060.74161240
79Melanoma_Homo sapiens_hsa052180.73152839
80Fructose and mannose metabolism_Homo sapiens_hsa000510.72601321
81Adherens junction_Homo sapiens_hsa045200.72578594
82African trypanosomiasis_Homo sapiens_hsa051430.71855275
83Galactose metabolism_Homo sapiens_hsa000520.71389579
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70749382
85HIF-1 signaling pathway_Homo sapiens_hsa040660.70575797
86Toxoplasmosis_Homo sapiens_hsa051450.70524433
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70279037
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69577008
89ABC transporters_Homo sapiens_hsa020100.69503709
90GnRH signaling pathway_Homo sapiens_hsa049120.69397944
91Proteoglycans in cancer_Homo sapiens_hsa052050.68533090
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67476247
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.67461109
94Lysine degradation_Homo sapiens_hsa003100.66524693
95Pancreatic secretion_Homo sapiens_hsa049720.66031501
96Platelet activation_Homo sapiens_hsa046110.65375461
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64320356
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.64073826
99Tyrosine metabolism_Homo sapiens_hsa003500.63828922
100FoxO signaling pathway_Homo sapiens_hsa040680.63713549
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62726017
102Arginine biosynthesis_Homo sapiens_hsa002200.62058532
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.61570141
104Non-small cell lung cancer_Homo sapiens_hsa052230.61026182
105Influenza A_Homo sapiens_hsa051640.60258537
106Sphingolipid metabolism_Homo sapiens_hsa006000.59563295
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59553924
108Rap1 signaling pathway_Homo sapiens_hsa040150.59520805
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.58074209
110Insulin resistance_Homo sapiens_hsa049310.56749597
111Pertussis_Homo sapiens_hsa051330.55992670
112Long-term potentiation_Homo sapiens_hsa047200.55880939
113Chronic myeloid leukemia_Homo sapiens_hsa052200.55779462
114Calcium signaling pathway_Homo sapiens_hsa040200.55288368
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55026094
116Renal cell carcinoma_Homo sapiens_hsa052110.54864313
117Hepatitis B_Homo sapiens_hsa051610.54673836
118Other glycan degradation_Homo sapiens_hsa005110.51984859
119Ras signaling pathway_Homo sapiens_hsa040140.51799763
120ErbB signaling pathway_Homo sapiens_hsa040120.51737783
121Glutamatergic synapse_Homo sapiens_hsa047240.50690037
122Vitamin digestion and absorption_Homo sapiens_hsa049770.50407217
123Pancreatic cancer_Homo sapiens_hsa052120.50089928
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.49823776
125Thyroid hormone synthesis_Homo sapiens_hsa049180.49323166
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.49003066
127Endocytosis_Homo sapiens_hsa041440.48524994
128cAMP signaling pathway_Homo sapiens_hsa040240.48077295
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47731754
130Serotonergic synapse_Homo sapiens_hsa047260.47730079
131Choline metabolism in cancer_Homo sapiens_hsa052310.47181036
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.46461390
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46133664
134Tight junction_Homo sapiens_hsa045300.45694457
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.45156964

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