FMN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47). Alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.15497302
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.12311698
3neuron cell-cell adhesion (GO:0007158)4.86963135
4locomotory exploration behavior (GO:0035641)4.79634925
5vocalization behavior (GO:0071625)4.77815231
6synaptic vesicle exocytosis (GO:0016079)4.75811774
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.59858688
8glutamate secretion (GO:0014047)4.44111878
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.41692571
10regulation of synaptic vesicle exocytosis (GO:2000300)4.33791994
11synaptic vesicle maturation (GO:0016188)4.32033111
12protein localization to synapse (GO:0035418)4.13715775
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.13442117
14regulation of glutamate receptor signaling pathway (GO:1900449)4.09719567
15neuronal action potential propagation (GO:0019227)4.06293289
16regulation of synaptic vesicle transport (GO:1902803)3.93992328
17glutamate receptor signaling pathway (GO:0007215)3.91556909
18synaptic transmission, glutamatergic (GO:0035249)3.86009634
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.83207687
20exploration behavior (GO:0035640)3.74946716
21neurotransmitter-gated ion channel clustering (GO:0072578)3.73376240
22neurotransmitter secretion (GO:0007269)3.71608544
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70035047
24regulation of neuronal synaptic plasticity (GO:0048168)3.68945386
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.68139394
26gamma-aminobutyric acid transport (GO:0015812)3.64733778
27layer formation in cerebral cortex (GO:0021819)3.64079266
28cellular potassium ion homeostasis (GO:0030007)3.62041550
29presynaptic membrane assembly (GO:0097105)3.60839959
30neuron recognition (GO:0008038)3.59916807
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58897539
32neuron-neuron synaptic transmission (GO:0007270)3.58750474
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54265421
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.51148044
35synaptic vesicle endocytosis (GO:0048488)3.46015660
36postsynaptic membrane organization (GO:0001941)3.43279189
37dendritic spine morphogenesis (GO:0060997)3.40432449
38regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.37865402
39long-term memory (GO:0007616)3.31771902
40axonal fasciculation (GO:0007413)3.30370829
41cerebellar Purkinje cell differentiation (GO:0021702)3.27899322
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26153970
43positive regulation of synapse maturation (GO:0090129)3.25076177
44presynaptic membrane organization (GO:0097090)3.24518815
45transmission of nerve impulse (GO:0019226)3.23372068
46proline transport (GO:0015824)3.22722627
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22055758
48long-term synaptic potentiation (GO:0060291)3.21346469
49positive regulation of membrane potential (GO:0045838)3.19824628
50response to pheromone (GO:0019236)3.19059901
51innervation (GO:0060384)3.18650368
52neurotransmitter transport (GO:0006836)3.18613380
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17777394
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.17344123
55regulation of synapse structural plasticity (GO:0051823)3.14767422
56positive regulation of synapse assembly (GO:0051965)3.14502404
57regulation of postsynaptic membrane potential (GO:0060078)3.14134061
58detection of calcium ion (GO:0005513)3.12654459
59regulation of vesicle fusion (GO:0031338)3.12417738
60regulation of calcium ion-dependent exocytosis (GO:0017158)3.11406727
61central nervous system myelination (GO:0022010)3.10460387
62axon ensheathment in central nervous system (GO:0032291)3.10460387
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10421010
64regulation of synaptic plasticity (GO:0048167)3.09391447
65cerebellar granule cell differentiation (GO:0021707)3.07223388
66auditory behavior (GO:0031223)3.06013617
67response to histamine (GO:0034776)3.02890851
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01723164
69activation of protein kinase A activity (GO:0034199)3.01396426
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00803631
71amino acid import (GO:0043090)3.00291391
72sodium ion export (GO:0071436)2.99889915
73response to auditory stimulus (GO:0010996)2.99272288
74synapse assembly (GO:0007416)2.98682634
75positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98378660
76dendrite morphogenesis (GO:0048813)2.97480599
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93776380
78regulation of neurotransmitter levels (GO:0001505)2.92556028
79regulation of neurotransmitter secretion (GO:0046928)2.91870066
80potassium ion homeostasis (GO:0055075)2.91836540
81positive regulation of dendritic spine development (GO:0060999)2.91141175
82behavioral fear response (GO:0001662)2.87951466
83behavioral defense response (GO:0002209)2.87951466
84fear response (GO:0042596)2.85921759
85membrane hyperpolarization (GO:0060081)2.84945714
86regulation of respiratory system process (GO:0044065)2.82493101
87startle response (GO:0001964)2.82325743
88positive regulation of neurotransmitter transport (GO:0051590)2.81670072
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81136600
90neuronal ion channel clustering (GO:0045161)2.81050904
91regulation of synapse assembly (GO:0051963)2.80831452
92membrane depolarization during action potential (GO:0086010)2.80475880
93regulation of dendritic spine morphogenesis (GO:0061001)2.79664048
94L-amino acid import (GO:0043092)2.78882561
95regulation of axon extension involved in axon guidance (GO:0048841)2.75739695
96regulation of neurotransmitter transport (GO:0051588)2.75468767
97membrane depolarization (GO:0051899)2.74533439
98cell communication by electrical coupling (GO:0010644)2.74444284
99regulation of axon guidance (GO:1902667)2.74162685
100potassium ion import (GO:0010107)2.73948146
101regulation of neurotransmitter uptake (GO:0051580)2.73374890
102cAMP-mediated signaling (GO:0019933)2.73214573
103synapse organization (GO:0050808)2.72382740
104synaptic transmission (GO:0007268)2.71945828
105learning (GO:0007612)2.69647984
106cochlea development (GO:0090102)2.69537381
107chemosensory behavior (GO:0007635)2.69110127
108regulation of synaptic transmission (GO:0050804)2.68532604
109positive regulation of synaptic transmission (GO:0050806)2.68009645
110social behavior (GO:0035176)2.66779776
111intraspecies interaction between organisms (GO:0051703)2.66779776
112negative regulation of axon extension (GO:0030517)2.64960723
113mechanosensory behavior (GO:0007638)2.64649404
114neuromuscular process controlling balance (GO:0050885)2.64028279
115negative regulation of dendrite morphogenesis (GO:0050774)2.62833268
116cell migration in hindbrain (GO:0021535)2.62452422
117urinary tract smooth muscle contraction (GO:0014848)2.62198825
118neuromuscular synaptic transmission (GO:0007274)2.61478758
119regulation of dendritic spine development (GO:0060998)2.61328449
120central nervous system projection neuron axonogenesis (GO:0021952)2.60206431
121adult walking behavior (GO:0007628)2.58385270
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57345736
123negative regulation of axonogenesis (GO:0050771)2.56506967
124axon extension (GO:0048675)2.55637111
125pyrimidine nucleobase catabolic process (GO:0006208)2.52575715
126suckling behavior (GO:0001967)2.51055591
127regulation of synaptic transmission, GABAergic (GO:0032228)2.50942996
128positive regulation of catecholamine secretion (GO:0033605)2.49786228
129membrane assembly (GO:0071709)2.47230561
130regulation of synapse organization (GO:0050807)2.46834773

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73567234
2GBX2_23144817_ChIP-Seq_PC3_Human3.64861917
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77024771
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76331747
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71030839
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.55443138
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43414237
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43414237
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.36662900
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33627917
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33416926
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26063722
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22542733
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21719000
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20973593
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.17126400
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.10398703
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05168602
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.04130036
20DROSHA_22980978_ChIP-Seq_HELA_Human2.03960274
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03581261
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01727724
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00816677
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.00092491
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.99294409
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95677481
27TAF15_26573619_Chip-Seq_HEK293_Human1.85461967
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81901375
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78717799
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.78504235
31AR_21572438_ChIP-Seq_LNCaP_Human1.74940118
32* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73344692
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61153517
34* P300_19829295_ChIP-Seq_ESCs_Human1.60347710
35IGF1R_20145208_ChIP-Seq_DFB_Human1.59395604
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.57557163
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56952781
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53992475
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50436865
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50013231
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49631252
42RNF2_27304074_Chip-Seq_NSC_Mouse1.47903586
43STAT3_23295773_ChIP-Seq_U87_Human1.47524923
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45483484
45* PIAS1_25552417_ChIP-Seq_VCAP_Human1.42680309
46FUS_26573619_Chip-Seq_HEK293_Human1.41996038
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.38696305
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38070489
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37637269
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35222783
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33908622
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33589418
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.33266606
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32747528
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32672958
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32322523
57* AR_25329375_ChIP-Seq_VCAP_Human1.32318305
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.31220434
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29946039
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26486619
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24954403
62ZNF274_21170338_ChIP-Seq_K562_Hela1.24296659
63TP53_16413492_ChIP-PET_HCT116_Human1.23932671
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23150070
65TCF4_23295773_ChIP-Seq_U87_Human1.22639419
66* AR_19668381_ChIP-Seq_PC3_Human1.22291489
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.21163407
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.20952620
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20921267
70* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20396212
71TP53_18474530_ChIP-ChIP_U2OS_Human1.19265738
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18897968
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.18302248
74* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17056347
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16177654
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14969620
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.14800996
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14485704
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14485704
80* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14033177
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13209360
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12707596
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12238824
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11420617
85* RUNX2_22187159_ChIP-Seq_PCA_Human1.11055075
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10907535
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09740804
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09217360
89* RING1B_27294783_Chip-Seq_NPCs_Mouse1.08797614
90* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08688879
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08552056
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08552056
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08501584
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08392733
95VDR_22108803_ChIP-Seq_LS180_Human1.08352415
96* NANOG_18555785_Chip-Seq_ESCs_Mouse1.07739126
97* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07430704
98BCAT_22108803_ChIP-Seq_LS180_Human1.07341598
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07236618
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06853590
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06355283
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03982955
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02599097
104SMAD3_21741376_ChIP-Seq_ESCs_Human1.02415384
105CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02112833
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00542674
107AHR_22903824_ChIP-Seq_MCF-7_Human1.00068007
108KDM2B_26808549_Chip-Seq_REH_Human0.99856665
109* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99807149
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.99588161
111* SMAD3_21741376_ChIP-Seq_HESCs_Human0.98702485
112* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97129321
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93347210
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91897092
115* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91500909
116* JUN_21703547_ChIP-Seq_K562_Human0.90126888
117* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89158506
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88163960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.06794376
2MP0003880_abnormal_central_pattern4.68151156
3MP0003635_abnormal_synaptic_transmissio3.56912858
4MP0004270_analgesia3.38661123
5MP0002063_abnormal_learning/memory/cond2.87623832
6MP0005423_abnormal_somatic_nervous2.86776066
7MP0009745_abnormal_behavioral_response2.83602427
8MP0002064_seizures2.71404642
9MP0009046_muscle_twitch2.65839405
10MP0002572_abnormal_emotion/affect_behav2.59996808
11MP0009780_abnormal_chondrocyte_physiolo2.47602305
12MP0001486_abnormal_startle_reflex2.46282970
13MP0002734_abnormal_mechanical_nocicepti2.45133926
14MP0001968_abnormal_touch/_nociception2.43866911
15MP0005646_abnormal_pituitary_gland2.43742920
16MP0002272_abnormal_nervous_system2.34037177
17MP0001984_abnormal_olfaction2.10432189
18MP0000778_abnormal_nervous_system2.05216783
19MP0003787_abnormal_imprinting2.02989523
20MP0005623_abnormal_meninges_morphology2.01376648
21MP0001501_abnormal_sleep_pattern2.00533490
22MP0001440_abnormal_grooming_behavior1.99066020
23MP0002733_abnormal_thermal_nociception1.91428947
24MP0006276_abnormal_autonomic_nervous1.90148972
25MP0002736_abnormal_nociception_after1.88189515
26MP0005503_abnormal_tendon_morphology1.84882726
27MP0002067_abnormal_sensory_capabilities1.82825016
28MP0008438_abnormal_cutaneous_collagen1.79912337
29MP0001970_abnormal_pain_threshold1.78259406
30MP0002909_abnormal_adrenal_gland1.77846325
31MP0005645_abnormal_hypothalamus_physiol1.74065751
32* MP0002557_abnormal_social/conspecific_i1.73343635
33MP0002184_abnormal_innervation1.72349950
34MP0002735_abnormal_chemical_nociception1.70852175
35MP0002653_abnormal_ependyma_morphology1.68063673
36MP0001958_emphysema1.66145796
37MP0008569_lethality_at_weaning1.59875602
38MP0004885_abnormal_endolymph1.59503025
39MP0000955_abnormal_spinal_cord1.58351270
40MP0001502_abnormal_circadian_rhythm1.57269630
41MP0005386_behavior/neurological_phenoty1.55402623
42MP0004924_abnormal_behavior1.55402623
43MP0001529_abnormal_vocalization1.49124091
44MP0004858_abnormal_nervous_system1.47283543
45MP0003122_maternal_imprinting1.46451069
46MP0002822_catalepsy1.45614548
47MP0002882_abnormal_neuron_morphology1.44118535
48MP0003329_amyloid_beta_deposits1.42764484
49MP0003283_abnormal_digestive_organ1.42417853
50MP0001188_hyperpigmentation1.40028071
51MP0004811_abnormal_neuron_physiology1.39114224
52MP0003879_abnormal_hair_cell1.38120212
53MP0006292_abnormal_olfactory_placode1.36681912
54MP0006072_abnormal_retinal_apoptosis1.30212319
55MP0010386_abnormal_urinary_bladder1.29881078
56MP0002066_abnormal_motor_capabilities/c1.27792497
57MP0001905_abnormal_dopamine_level1.26384707
58MP0002638_abnormal_pupillary_reflex1.25311905
59MP0000534_abnormal_ureter_morphology1.25132784
60MP0000631_abnormal_neuroendocrine_gland1.24865971
61MP0005499_abnormal_olfactory_system1.20848091
62MP0005394_taste/olfaction_phenotype1.20848091
63MP0003279_aneurysm1.19663023
64MP0005257_abnormal_intraocular_pressure1.19544753
65MP0002152_abnormal_brain_morphology1.19016890
66MP0004043_abnormal_pH_regulation1.18248916
67MP0004133_heterotaxia1.17891696
68MP0004145_abnormal_muscle_electrophysio1.16058232
69MP0000566_synostosis1.14812373
70MP0004142_abnormal_muscle_tone1.13246726
71MP0005551_abnormal_eye_electrophysiolog1.12843836
72MP0005171_absent_coat_pigmentation1.11997035
73MP0001485_abnormal_pinna_reflex1.11963558
74MP0003633_abnormal_nervous_system1.11521455
75MP0004742_abnormal_vestibular_system1.03584986
76MP0001348_abnormal_lacrimal_gland1.02514353
77MP0001963_abnormal_hearing_physiology0.99905513
78MP0003634_abnormal_glial_cell0.99048843
79MP0005379_endocrine/exocrine_gland_phen0.98052869
80MP0009384_cardiac_valve_regurgitation0.97910002
81MP0009250_abnormal_appendicular_skeleto0.97148655
82MP0002229_neurodegeneration0.96994380
83MP0000013_abnormal_adipose_tissue0.96959357
84MP0003121_genomic_imprinting0.96089266
85MP0003631_nervous_system_phenotype0.95633524
86MP0000920_abnormal_myelination0.94885291
87MP0003942_abnormal_urinary_system0.93893305
88MP0002752_abnormal_somatic_nervous0.91304999
89MP0010368_abnormal_lymphatic_system0.90869106
90MP0002837_dystrophic_cardiac_calcinosis0.89721083
91MP0003183_abnormal_peptide_metabolism0.88458541
92MP0003890_abnormal_embryonic-extraembry0.87625845
93MP0002069_abnormal_eating/drinking_beha0.86481989
94MP0002102_abnormal_ear_morphology0.86307323
95MP0001299_abnormal_eye_distance/0.84268482
96MP0000026_abnormal_inner_ear0.79850585
97MP0002295_abnormal_pulmonary_circulatio0.79730365
98MP0003861_abnormal_nervous_system0.79649129
99MP0000462_abnormal_digestive_system0.78278726
100MP0000569_abnormal_digit_pigmentation0.76904443
101MP0008961_abnormal_basal_metabolism0.76009807
102MP0003632_abnormal_nervous_system0.75477880
103MP0005253_abnormal_eye_physiology0.75233695
104MP0003119_abnormal_digestive_system0.74819924
105MP0003705_abnormal_hypodermis_morpholog0.74642932
106MP0008789_abnormal_olfactory_epithelium0.73854297
107MP0004085_abnormal_heartbeat0.73853163
108MP0003385_abnormal_body_wall0.73828985
109MP0003690_abnormal_glial_cell0.72370962
110MP0004134_abnormal_chest_morphology0.72350954
111MP0008877_abnormal_DNA_methylation0.71587119
112MP0001944_abnormal_pancreas_morphology0.71470038
113MP0005508_abnormal_skeleton_morphology0.71098757
114MP0002938_white_spotting0.70373988
115MP0003937_abnormal_limbs/digits/tail_de0.70308519
116MP0005535_abnormal_body_temperature0.69209172
117MP0002751_abnormal_autonomic_nervous0.67170489
118MP0000049_abnormal_middle_ear0.66936739
119MP0005187_abnormal_penis_morphology0.65413360
120MP0002876_abnormal_thyroid_physiology0.65411180
121MP0001664_abnormal_digestion0.64783369
122MP0002693_abnormal_pancreas_physiology0.63464236
123MP0008872_abnormal_physiological_respon0.61432275
124MP0003137_abnormal_impulse_conducting0.60695704
125MP0004215_abnormal_myocardial_fiber0.57935199
126MP0001943_abnormal_respiration0.56586726
127MP0001177_atelectasis0.56392069

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.34958410
2Focal seizures (HP:0007359)4.54008190
3Myokymia (HP:0002411)4.37943797
4Epileptic encephalopathy (HP:0200134)4.31507358
5Visual hallucinations (HP:0002367)4.18834552
6Atonic seizures (HP:0010819)4.10596390
7Progressive cerebellar ataxia (HP:0002073)3.81907509
8Febrile seizures (HP:0002373)3.77319112
9Absence seizures (HP:0002121)3.62438401
10Generalized tonic-clonic seizures (HP:0002069)3.40918097
11Dialeptic seizures (HP:0011146)3.34365203
12Action tremor (HP:0002345)3.03252645
13Hyperventilation (HP:0002883)3.02612919
14Genetic anticipation (HP:0003743)2.87387870
15Broad-based gait (HP:0002136)2.87337056
16Hemiparesis (HP:0001269)2.84523936
17Drooling (HP:0002307)2.80640325
18Excessive salivation (HP:0003781)2.80640325
19Abnormal respiratory motile cilium physiology (HP:0012261)2.78221392
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.72848609
21Premature rupture of membranes (HP:0001788)2.72686384
22Abnormal ciliary motility (HP:0012262)2.71957602
23Megalencephaly (HP:0001355)2.70014246
24Epileptiform EEG discharges (HP:0011182)2.67500679
25Supranuclear gaze palsy (HP:0000605)2.67458343
26Gaze-evoked nystagmus (HP:0000640)2.64039876
27Obstructive sleep apnea (HP:0002870)2.63104853
28EEG with generalized epileptiform discharges (HP:0011198)2.60458577
29Dysdiadochokinesis (HP:0002075)2.59720348
30Amblyopia (HP:0000646)2.58893267
31Torticollis (HP:0000473)2.58888730
32Papilledema (HP:0001085)2.58532661
33Gait imbalance (HP:0002141)2.58022272
34Protrusio acetabuli (HP:0003179)2.53626333
35Hypoventilation (HP:0002791)2.46590715
36Aplasia involving bones of the extremities (HP:0009825)2.46440857
37Aplasia involving bones of the upper limbs (HP:0009823)2.46440857
38Aplasia of the phalanges of the hand (HP:0009802)2.46440857
39Neurofibrillary tangles (HP:0002185)2.46172116
40Diplopia (HP:0000651)2.44867732
41Abnormality of binocular vision (HP:0011514)2.44867732
42Shallow orbits (HP:0000586)2.44858342
43Bowel diverticulosis (HP:0005222)2.42253902
44Urinary bladder sphincter dysfunction (HP:0002839)2.42207400
45Abnormal eating behavior (HP:0100738)2.41836322
46Hypsarrhythmia (HP:0002521)2.40216498
47Ankle clonus (HP:0011448)2.39053365
48Dysmetria (HP:0001310)2.38043694
49Impaired vibration sensation in the lower limbs (HP:0002166)2.37962539
50Depression (HP:0000716)2.37911666
51Truncal ataxia (HP:0002078)2.36304663
52Absent speech (HP:0001344)2.33412373
53Broad metatarsal (HP:0001783)2.32342044
54Impaired smooth pursuit (HP:0007772)2.31195110
55Agitation (HP:0000713)2.28905584
56Congenital primary aphakia (HP:0007707)2.25030607
57Thickened helices (HP:0000391)2.24022639
58Cerebral inclusion bodies (HP:0100314)2.23876802
59Anxiety (HP:0000739)2.22333910
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19684442
61Rhinitis (HP:0012384)2.19514117
62Limb dystonia (HP:0002451)2.18846285
63Poor eye contact (HP:0000817)2.17124338
64Medial flaring of the eyebrow (HP:0010747)2.12884944
65Neonatal short-limb short stature (HP:0008921)2.11601694
66Postural instability (HP:0002172)2.11228984
67Sleep apnea (HP:0010535)2.10494919
68Mild short stature (HP:0003502)2.08939077
69Overgrowth (HP:0001548)2.08552867
70Abnormality of dentin (HP:0010299)2.08063917
71Coronal craniosynostosis (HP:0004440)2.07747031
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.05351421
73Absent/shortened dynein arms (HP:0200106)2.05351421
74Termporal pattern (HP:0011008)2.04307914
75Insidious onset (HP:0003587)2.04307914
76Nephrogenic diabetes insipidus (HP:0009806)2.03849810
77Polyphagia (HP:0002591)2.03503966
78Abnormality of midbrain morphology (HP:0002418)2.01033602
79Molar tooth sign on MRI (HP:0002419)2.01033602
80Vascular tortuosity (HP:0004948)2.00582643
81Abnormality of ocular smooth pursuit (HP:0000617)1.99842380
82Abnormal respiratory motile cilium morphology (HP:0005938)1.99658523
83Abnormal respiratory epithelium morphology (HP:0012253)1.99658523
84Spastic gait (HP:0002064)1.99575736
85Morphological abnormality of the middle ear (HP:0008609)1.98880981
86Specific learning disability (HP:0001328)1.98553833
87Abnormality of salivation (HP:0100755)1.98110299
88Papillary thyroid carcinoma (HP:0002895)1.97766802
89Genital tract atresia (HP:0001827)1.95381480
90Intention tremor (HP:0002080)1.93642317
91Abnormal social behavior (HP:0012433)1.93460033
92Impaired social interactions (HP:0000735)1.93460033
93Bladder diverticulum (HP:0000015)1.91998921
94Genu recurvatum (HP:0002816)1.91542459
95Soft skin (HP:0000977)1.90101940
96Vaginal atresia (HP:0000148)1.89494148
97Abnormality of calcium-phosphate metabolism (HP:0100530)1.87918394
98Focal dystonia (HP:0004373)1.87917251
99Wide anterior fontanel (HP:0000260)1.86952567
100Aortic aneurysm (HP:0004942)1.86497464
101Intestinal atresia (HP:0011100)1.84549521
102Ankle contracture (HP:0006466)1.83988896
103Hemiplegia (HP:0002301)1.83727525
104Abnormality of the corticospinal tract (HP:0002492)1.83094404
105Follicular hyperkeratosis (HP:0007502)1.82690583
106Bradykinesia (HP:0002067)1.82659740
107Scanning speech (HP:0002168)1.82326632
108Protruding tongue (HP:0010808)1.81725996
109Hypoplasia of the iris (HP:0007676)1.80110561
110Fetal akinesia sequence (HP:0001989)1.78780010
111Pheochromocytoma (HP:0002666)1.78756441
112Increased circulating renin level (HP:0000848)1.78684199
113Retinal dysplasia (HP:0007973)1.78530219
114Abnormality of the labia minora (HP:0012880)1.76344018
115Hyperinsulinemic hypoglycemia (HP:0000825)1.76026670
116Turricephaly (HP:0000262)1.75997372
117Pancreatic fibrosis (HP:0100732)1.75421515
118Lower limb muscle weakness (HP:0007340)1.75407866
119Craniofacial dystonia (HP:0012179)1.75397480
120Failure to thrive in infancy (HP:0001531)1.74521298
121Impaired vibratory sensation (HP:0002495)1.74348495
122Stereotypic behavior (HP:0000733)1.73688303
123Blue irides (HP:0000635)1.69949740
124Aqueductal stenosis (HP:0002410)1.69686882
125Oligodactyly (hands) (HP:0001180)1.69502728
126Postural tremor (HP:0002174)1.69159723
127Chronic bronchitis (HP:0004469)1.67750675
128Shawl scrotum (HP:0000049)1.66898711
129Generalized myoclonic seizures (HP:0002123)1.66794763
130Urinary urgency (HP:0000012)1.66297419
131Widely spaced teeth (HP:0000687)1.65459703
132Hyperthyroidism (HP:0000836)1.65365379
133Abnormality of the lower motor neuron (HP:0002366)1.63551807
134Renal duplication (HP:0000075)1.61937447
135Aortic dissection (HP:0002647)1.59374697
136Arterial tortuosity (HP:0005116)1.57522276
137Hyperextensible skin (HP:0000974)1.57262719
138Cutaneous finger syndactyly (HP:0010554)1.56595409
139Round face (HP:0000311)1.55759278
140Delayed gross motor development (HP:0002194)1.54820023
141Bell-shaped thorax (HP:0001591)1.53207299
142Atrioventricular canal defect (HP:0006695)1.49631636
143Insomnia (HP:0100785)1.48247425
144Buphthalmos (HP:0000557)1.47323848
145Mitral regurgitation (HP:0001653)1.45996449
146Complete atrioventricular canal defect (HP:0001674)1.44563541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.23371296
2EPHA43.63368837
3MAP3K93.15800248
4MAP3K43.08000754
5MARK12.78793183
6MAP2K72.69264355
7PRKD32.51367118
8CASK2.50032799
9NTRK22.46294905
10FRK2.41661323
11MINK12.04721715
12PNCK2.03277041
13PAK61.97858649
14TNIK1.95434254
15KSR21.73358055
16MAP2K41.71587662
17MAPK131.70893362
18NTRK11.59400465
19DAPK21.58141752
20MAP3K61.52047523
21KSR11.50813222
22LATS21.42782008
23INSRR1.40178263
24UHMK11.37973700
25DDR21.32947216
26CDK51.32377143
27FGFR21.28823397
28TYRO31.28410473
29PLK21.25824334
30GRK51.25179695
31LIMK11.24074701
32TAOK31.23271705
33PRPF4B1.21582049
34PDGFRA1.20913122
35BMPR21.19351404
36RIPK41.18628382
37STK381.17019388
38WNK31.12437546
39SGK4941.09512930
40SGK2231.09512930
41MAP3K121.07046044
42ARAF1.06740470
43CAMK2A1.05806884
44CAMKK11.04859041
45PTK21.03755330
46PHKG11.03090872
47PHKG21.03090872
48PRKCG1.02302567
49MAP3K21.01583328
50DAPK10.98884439
51SGK20.98616881
52CAMK1G0.91369072
53MAP3K130.91261863
54MYLK0.91054448
55PAK30.91020618
56CDK190.90020219
57BRAF0.89703506
58PINK10.89205786
59SIK20.88847010
60CSNK1G20.87944497
61DYRK1A0.85377417
62PAK20.85201327
63FES0.84873215
64CAMK2B0.83161726
65PKN10.83037496
66MARK20.80930912
67ROCK10.78901430
68AKT30.78530883
69CDK180.78204592
70ROCK20.77805385
71CDC42BPA0.76605928
72CDK150.76484390
73RET0.76062654
74OXSR10.74380307
75PTK2B0.74287392
76MUSK0.73024349
77SGK10.71511400
78CAMKK20.71498113
79CDK140.70777616
80STK110.69449532
81HIPK20.69040641
82CDK30.68416182
83NEK90.67977561
84RAF10.65090782
85PDGFRB0.64168299
86CDK11A0.63763165
87CAMK10.62420356
88PRKCH0.61886092
89ACVR1B0.61319250
90RIPK10.61197248
91SGK30.61124002
92TRIM280.61013553
93MAPK150.59069810
94CAMK2D0.58551264
95MAPK100.58068056
96NEK60.57527411
97PRKCE0.57216323
98EPHB20.55713320
99PRKD20.55407090
100BMPR1B0.53755788
101CAMK40.53422702
102TAOK10.53413119
103RPS6KA30.52930296
104MAP3K10.52408019
105MAP2K10.50365935
106ERBB40.47676483
107MKNK20.47389381
108LATS10.46988256
109PRKAA10.46663840
110PRKCZ0.46530859
111STK38L0.44997774
112CAMK2G0.44992231
113DYRK20.44699614
114CSNK1A1L0.43791093
115WNK10.43769574
116ADRBK20.42269000
117FGR0.42175864
118MOS0.38889739
119ADRBK10.38887096
120NME10.37994092
121CSNK1G10.36867604
122PRKG10.36650813
123BCR0.36247261
124CSNK1G30.36214930
125PRKACA0.35946737
126WNK40.35872863

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68285091
2Synaptic vesicle cycle_Homo sapiens_hsa047212.80278543
3GABAergic synapse_Homo sapiens_hsa047272.73408665
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66736198
5Glutamatergic synapse_Homo sapiens_hsa047242.62435623
6Olfactory transduction_Homo sapiens_hsa047402.60728047
7Circadian entrainment_Homo sapiens_hsa047132.58879188
8Insulin secretion_Homo sapiens_hsa049112.57703882
9Long-term potentiation_Homo sapiens_hsa047202.49492170
10Morphine addiction_Homo sapiens_hsa050322.47388092
11Amphetamine addiction_Homo sapiens_hsa050312.43261597
12Dopaminergic synapse_Homo sapiens_hsa047282.12276624
13Taste transduction_Homo sapiens_hsa047422.06814644
14Salivary secretion_Homo sapiens_hsa049702.00589545
15Serotonergic synapse_Homo sapiens_hsa047261.89232209
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83814250
17Cholinergic synapse_Homo sapiens_hsa047251.83788814
18Cocaine addiction_Homo sapiens_hsa050301.81878296
19Long-term depression_Homo sapiens_hsa047301.74472738
20Gastric acid secretion_Homo sapiens_hsa049711.74242142
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74232788
22Renin secretion_Homo sapiens_hsa049241.68917572
23Oxytocin signaling pathway_Homo sapiens_hsa049211.45981831
24Calcium signaling pathway_Homo sapiens_hsa040201.45615431
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45289484
26GnRH signaling pathway_Homo sapiens_hsa049121.41743283
27Collecting duct acid secretion_Homo sapiens_hsa049661.39989270
28Type II diabetes mellitus_Homo sapiens_hsa049301.39782081
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34989514
30cAMP signaling pathway_Homo sapiens_hsa040241.34368957
31Gap junction_Homo sapiens_hsa045401.29197266
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.28049483
33Circadian rhythm_Homo sapiens_hsa047101.26571696
34Nitrogen metabolism_Homo sapiens_hsa009101.24915144
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23422805
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23015485
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21823163
38Estrogen signaling pathway_Homo sapiens_hsa049151.19158136
39Hippo signaling pathway_Homo sapiens_hsa043901.17521435
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16948623
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08535983
42Melanogenesis_Homo sapiens_hsa049161.07978420
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07573311
44Axon guidance_Homo sapiens_hsa043601.05763738
45Pancreatic secretion_Homo sapiens_hsa049721.04180148
46Vitamin B6 metabolism_Homo sapiens_hsa007501.02304634
47Vibrio cholerae infection_Homo sapiens_hsa051101.01733905
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.00343109
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00151106
50* Dorso-ventral axis formation_Homo sapiens_hsa043200.99837634
51Oocyte meiosis_Homo sapiens_hsa041140.94032534
52Thyroid hormone synthesis_Homo sapiens_hsa049180.90208967
53ErbB signaling pathway_Homo sapiens_hsa040120.89694630
54Glioma_Homo sapiens_hsa052140.89603665
55ECM-receptor interaction_Homo sapiens_hsa045120.84828291
56Phototransduction_Homo sapiens_hsa047440.84550255
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83912463
58Cardiac muscle contraction_Homo sapiens_hsa042600.83051955
59Choline metabolism in cancer_Homo sapiens_hsa052310.81652912
60Ovarian steroidogenesis_Homo sapiens_hsa049130.81126352
61Basal cell carcinoma_Homo sapiens_hsa052170.80193237
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.74533398
63Focal adhesion_Homo sapiens_hsa045100.73436031
64Glucagon signaling pathway_Homo sapiens_hsa049220.72927124
65Type I diabetes mellitus_Homo sapiens_hsa049400.71142437
66MAPK signaling pathway_Homo sapiens_hsa040100.69242163
67Melanoma_Homo sapiens_hsa052180.69239571
68Wnt signaling pathway_Homo sapiens_hsa043100.66087933
69Protein digestion and absorption_Homo sapiens_hsa049740.64551772
70Hedgehog signaling pathway_Homo sapiens_hsa043400.64351032
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64139727
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63790617
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63484331
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62556688
75Ras signaling pathway_Homo sapiens_hsa040140.62182103
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61087061
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60599024
78Dilated cardiomyopathy_Homo sapiens_hsa054140.59983843
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58795613
80Alcoholism_Homo sapiens_hsa050340.57323980
81mTOR signaling pathway_Homo sapiens_hsa041500.56975504
82Tight junction_Homo sapiens_hsa045300.56512508
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55350065
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55201813
85TGF-beta signaling pathway_Homo sapiens_hsa043500.54829149
86Butanoate metabolism_Homo sapiens_hsa006500.50510487
87Proteoglycans in cancer_Homo sapiens_hsa052050.49694553
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49639127
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48704437
90Inositol phosphate metabolism_Homo sapiens_hsa005620.48396504
91Renal cell carcinoma_Homo sapiens_hsa052110.47384597
92Prion diseases_Homo sapiens_hsa050200.45947238
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.45304391
94Adherens junction_Homo sapiens_hsa045200.44872631
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44010761
96Bile secretion_Homo sapiens_hsa049760.43568809
97Rap1 signaling pathway_Homo sapiens_hsa040150.43470931
98VEGF signaling pathway_Homo sapiens_hsa043700.42785520
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41337339
100Fatty acid biosynthesis_Homo sapiens_hsa000610.40680984
101Ether lipid metabolism_Homo sapiens_hsa005650.40560755
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40296979
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39756074
104Endometrial cancer_Homo sapiens_hsa052130.39732974
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.39640818
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39337844
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38437704
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.37444720
109Insulin signaling pathway_Homo sapiens_hsa049100.36530086
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35437430
111AMPK signaling pathway_Homo sapiens_hsa041520.35035012
112Alzheimers disease_Homo sapiens_hsa050100.34102381
113MicroRNAs in cancer_Homo sapiens_hsa052060.34010815
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33271493
115Colorectal cancer_Homo sapiens_hsa052100.32255928
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30169680
117Prolactin signaling pathway_Homo sapiens_hsa049170.29200494
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27831619

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