FMNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.02582805
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.53149526
3negative regulation of cell killing (GO:0031342)6.53149526
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.78304394
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.78304394
6regulation of gamma-delta T cell differentiation (GO:0045586)5.69416745
7antigen processing and presentation of endogenous antigen (GO:0019883)5.48300682
8regulation of gamma-delta T cell activation (GO:0046643)5.29534045
9negative T cell selection (GO:0043383)5.13664794
10negative thymic T cell selection (GO:0045060)5.08162671
11response to interleukin-15 (GO:0070672)5.05753388
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.00842411
13regulation of B cell receptor signaling pathway (GO:0050855)4.95371904
14leukocyte aggregation (GO:0070486)4.94935869
15positive thymic T cell selection (GO:0045059)4.93178590
16detection of other organism (GO:0098543)4.75976238
17response to peptidoglycan (GO:0032494)4.71573866
18detection of bacterium (GO:0016045)4.63547350
19B cell receptor signaling pathway (GO:0050853)4.54803473
20cellular response to interleukin-15 (GO:0071350)4.49122272
21thymic T cell selection (GO:0045061)4.47451438
22T cell selection (GO:0045058)4.45327513
23positive T cell selection (GO:0043368)4.43873711
24tolerance induction (GO:0002507)4.37631801
25T cell migration (GO:0072678)4.34340667
26positive regulation of B cell differentiation (GO:0045579)4.32893535
27regulation of B cell differentiation (GO:0045577)4.30777911
28interferon-gamma production (GO:0032609)4.09897978
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.03644186
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98040330
31detection of external biotic stimulus (GO:0098581)3.90671567
32antigen receptor-mediated signaling pathway (GO:0050851)3.75687198
33regulation of interleukin-12 biosynthetic process (GO:0045075)3.73128024
34activated T cell proliferation (GO:0050798)3.70647537
35T cell receptor signaling pathway (GO:0050852)3.67139084
36response to host immune response (GO:0052572)3.67099593
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.67099593
38regulation of mast cell degranulation (GO:0043304)3.60388040
39positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.58169550
40cellular extravasation (GO:0045123)3.58167831
41detection of molecule of bacterial origin (GO:0032490)3.56687713
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.54295599
43T cell homeostasis (GO:0043029)3.49494586
44T cell costimulation (GO:0031295)3.49327542
45detection of biotic stimulus (GO:0009595)3.45829653
46mast cell activation (GO:0045576)3.45210269
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.43835844
48response to host (GO:0075136)3.43835844
49response to host defenses (GO:0052200)3.43835844
50lymphocyte costimulation (GO:0031294)3.43016615
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39812950
52positive regulation by organism of defense response of other organism involved in symbiotic interact3.39812950
53modulation by symbiont of host immune response (GO:0052553)3.39812950
54positive regulation by symbiont of host defense response (GO:0052509)3.39812950
55modulation by symbiont of host defense response (GO:0052031)3.39812950
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39812950
57leukocyte migration involved in inflammatory response (GO:0002523)3.39537569
58cellular response to type I interferon (GO:0071357)3.37464106
59type I interferon signaling pathway (GO:0060337)3.37464106
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.37234130
61positive regulation of interleukin-2 production (GO:0032743)3.37206938
62response to type I interferon (GO:0034340)3.35750513
63regulation of tolerance induction (GO:0002643)3.35363935
64microglial cell activation (GO:0001774)3.35291029
65negative regulation of phagocytosis (GO:0050765)3.34044346
66JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.33531727
67leukocyte cell-cell adhesion (GO:0007159)3.32000169
68mature B cell differentiation (GO:0002335)3.31945983
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.30942752
70regulation of interleukin-2 biosynthetic process (GO:0045076)3.30929081
71regulation of myeloid leukocyte mediated immunity (GO:0002886)3.30284971
72regulation of mast cell activation involved in immune response (GO:0033006)3.30259024
73regulation of T cell tolerance induction (GO:0002664)3.27731592
74regulation of alpha-beta T cell proliferation (GO:0046640)3.27602888
75macrophage activation (GO:0042116)3.27456108
76lymphocyte homeostasis (GO:0002260)3.23940448
77regulation of leukocyte degranulation (GO:0043300)3.23661241
78natural killer cell differentiation (GO:0001779)3.23106334
79regulation of isotype switching to IgG isotypes (GO:0048302)3.21965914
80mast cell activation involved in immune response (GO:0002279)3.20800527
81mast cell degranulation (GO:0043303)3.20800527
82antigen processing and presentation via MHC class Ib (GO:0002475)3.18846313
83leukocyte degranulation (GO:0043299)3.17872854
84neutrophil mediated immunity (GO:0002446)3.17852587
85positive regulation of mast cell activation (GO:0033005)3.17750688
86regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17434615
87myeloid dendritic cell activation (GO:0001773)3.11882545
88regulation of mast cell activation (GO:0033003)3.10961391
89positive regulation of isotype switching (GO:0045830)3.10808756
90immune response-activating cell surface receptor signaling pathway (GO:0002429)3.10220150
91regulation of interferon-beta biosynthetic process (GO:0045357)3.09760894
92negative regulation of erythrocyte differentiation (GO:0045647)3.07795428
93NIK/NF-kappaB signaling (GO:0038061)3.06617511
94negative regulation of interleukin-12 production (GO:0032695)3.06046209
95Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04629299
96negative regulation of T cell mediated immunity (GO:0002710)3.04179808
97neutrophil activation (GO:0042119)3.03501302
98negative regulation of innate immune response (GO:0045824)3.01251601
99production of molecular mediator involved in inflammatory response (GO:0002532)3.00952902
100B cell mediated immunity (GO:0019724)3.00549038
101negative regulation of interleukin-6 production (GO:0032715)2.99909376
102regulation of regulatory T cell differentiation (GO:0045589)2.99885746
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.98815409
104negative regulation of cytokine production involved in immune response (GO:0002719)2.98426469
105regulation of T cell receptor signaling pathway (GO:0050856)2.97992095
106negative regulation of lymphocyte mediated immunity (GO:0002707)2.97807354
107positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97257775
108immunoglobulin mediated immune response (GO:0016064)2.96842504
109myeloid dendritic cell differentiation (GO:0043011)2.96110743
110T cell proliferation (GO:0042098)2.96017053
111natural killer cell activation (GO:0030101)2.95811423
112interferon-gamma-mediated signaling pathway (GO:0060333)2.95174496
113regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94869812
114regulation of natural killer cell mediated immunity (GO:0002715)2.94869812
115regulation of T cell mediated cytotoxicity (GO:0001914)2.93889059
116positive regulation of histone deacetylation (GO:0031065)2.93002493
117regulation of T-helper 2 cell differentiation (GO:0045628)2.92992376
118myeloid cell activation involved in immune response (GO:0002275)2.92799960
119positive regulation of granulocyte differentiation (GO:0030854)2.89940797
120B cell homeostasis (GO:0001782)2.89610145
121negative regulation of T-helper cell differentiation (GO:0045623)2.89138537
122negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.89138537
123macrophage activation involved in immune response (GO:0002281)2.88772777
124response to protozoan (GO:0001562)2.88681378
125neutrophil activation involved in immune response (GO:0002283)2.88524825
126response to muramyl dipeptide (GO:0032495)2.88493048
127negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.88045540
128positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87570651
129negative regulation of leukocyte mediated immunity (GO:0002704)2.86528416
130granulocyte activation (GO:0036230)2.83406399
131positive regulation of tolerance induction (GO:0002645)2.82686340
132leukocyte homeostasis (GO:0001776)2.82633262
133regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81955277
134regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81613724
135regulation of response to interferon-gamma (GO:0060330)2.80259370
136regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.78987596
137germinal center formation (GO:0002467)2.78436456
138respiratory burst (GO:0045730)2.76414105
139defense response to protozoan (GO:0042832)2.75951248
140megakaryocyte development (GO:0035855)2.74777020

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.23407138
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.05973151
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.27061284
4MYC_22102868_ChIP-Seq_BL_Human4.09779159
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.65733783
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.47675640
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.42437870
8VDR_21846776_ChIP-Seq_THP-1_Human3.30420764
9RUNX_20019798_ChIP-Seq_JUKART_Human3.19379453
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.19212974
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08626134
12* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.02350941
13E2F7_22180533_ChIP-Seq_HELA_Human2.89177628
14* MYB_26560356_Chip-Seq_TH2_Human2.85602802
15SCL_19346495_ChIP-Seq_HPC-7_Human2.84762209
16* MAF_26560356_Chip-Seq_TH1_Human2.83722283
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.82766064
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.80785181
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80277562
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74630396
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.65427938
22* TCF7_22412390_ChIP-Seq_EML_Mouse2.63171359
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62316666
24* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58560448
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56535607
26* UTX_26944678_Chip-Seq_JUKART_Human2.55328278
27MYB_26560356_Chip-Seq_TH1_Human2.54564899
28* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48655944
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.45211631
30VDR_24763502_ChIP-Seq_THP-1_Human2.41206402
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.35380087
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.24625334
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20012926
34* KDM2B_26808549_Chip-Seq_DND41_Human2.19552069
35SPI1_23127762_ChIP-Seq_K562_Human2.18052374
36* RUNX1_22412390_ChIP-Seq_EML_Mouse2.18015547
37KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15394789
38* SPI1_23547873_ChIP-Seq_NB4_Human2.14091977
39* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12930340
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09550004
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91996946
42MAF_26560356_Chip-Seq_TH2_Human1.91509375
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89788794
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85745801
45* GATA3_27048872_Chip-Seq_THYMUS_Human1.76563698
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70036961
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.59006128
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.48588921
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47247304
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46248227
51CIITA_25753668_ChIP-Seq_RAJI_Human1.44913317
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44260360
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41128966
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37589464
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37449751
56* PU_27001747_Chip-Seq_BMDM_Mouse1.37182865
57* KDM2B_26808549_Chip-Seq_JURKAT_Human1.36764445
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36405498
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.35715256
60* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35656809
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33529334
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30455097
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29037885
64* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26404529
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.24692739
66* LXR_22292898_ChIP-Seq_THP-1_Human1.23180492
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21341355
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18205819
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18071122
70GATA3_26560356_Chip-Seq_TH2_Human1.13839116
71* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13799181
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13527010
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11247413
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10788585
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09767493
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09112733
77BCOR_27268052_Chip-Seq_Bcells_Human1.08785470
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08500714
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07113703
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06677157
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06074135
82* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04671530
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.02247398
84RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00562498
85* NCOR1_26117541_ChIP-Seq_K562_Human1.00460679
86* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99855132
87GATA1_19941826_ChIP-Seq_K562_Human0.98761351
88* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98739346
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97816483
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97063893
91VDR_24787735_ChIP-Seq_THP-1_Human0.96691397
92GATA1_22025678_ChIP-Seq_K562_Human0.93998325
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93122932
94GATA2_19941826_ChIP-Seq_K562_Human0.91223343
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.90477919
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90033199
97* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89543625
98* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89191949
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87705968
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86727872
101SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.85617899
102BCL6_27268052_Chip-Seq_Bcells_Human0.81554708
103SPI1_20517297_ChIP-Seq_HL60_Human0.80832795
104ELF1_20517297_ChIP-Seq_JURKAT_Human0.78043680
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75025554
106* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74449420
107EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.74388658
108* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.73458008
109* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71358696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.80485062
2MP0003303_peritoneal_inflammation3.45244731
3MP0005671_abnormal_response_to3.39846134
4MP0000685_abnormal_immune_system3.36327655
5MP0001800_abnormal_humoral_immune3.34857704
6MP0001790_abnormal_immune_system3.30410598
7MP0005387_immune_system_phenotype3.30410598
8MP0003763_abnormal_thymus_physiology3.28292363
9MP0005000_abnormal_immune_tolerance2.91034388
10MP0003436_decreased_susceptibility_to2.88416523
11MP0002452_abnormal_antigen_presenting2.83895717
12MP0002723_abnormal_immune_serum2.79166975
13MP0002420_abnormal_adaptive_immunity2.78035807
14MP0001819_abnormal_immune_cell2.74876980
15MP0003300_gastrointestinal_ulcer2.69017503
16MP0002398_abnormal_bone_marrow2.66933356
17MP0002396_abnormal_hematopoietic_system2.56736150
18MP0009785_altered_susceptibility_to2.54533647
19MP0004510_myositis2.49134754
20MP0005025_abnormal_response_to2.46202404
21MP0002419_abnormal_innate_immunity2.38197082
22MP0000716_abnormal_immune_system2.36694552
23MP0001873_stomach_inflammation2.23520827
24MP0002405_respiratory_system_inflammati2.23098230
25MP0005464_abnormal_platelet_physiology2.22149273
26MP0000689_abnormal_spleen_morphology2.18279546
27MP0002166_altered_tumor_susceptibility2.15476183
28MP0002722_abnormal_immune_system2.13607992
29MP0004808_abnormal_hematopoietic_stem2.12437695
30MP0006082_CNS_inflammation2.10948310
31MP0002148_abnormal_hypersensitivity_rea2.09250514
32MP0000703_abnormal_thymus_morphology2.07694182
33MP0009278_abnormal_bone_marrow2.05812885
34MP0010155_abnormal_intestine_physiology2.00195973
35MP0002429_abnormal_blood_cell1.94793584
36MP0009333_abnormal_splenocyte_physiolog1.91803326
37MP0003866_abnormal_defecation1.90500171
38MP0004947_skin_inflammation1.85200886
39MP0008260_abnormal_autophagy1.84142273
40MP0002006_tumorigenesis1.78468176
41MP0001845_abnormal_inflammatory_respons1.75567888
42MP0001545_abnormal_hematopoietic_system1.69149584
43MP0005397_hematopoietic_system_phenotyp1.69149584
44MP0001853_heart_inflammation1.67355118
45MP0000465_gastrointestinal_hemorrhage1.66151209
46MP0005310_abnormal_salivary_gland1.54910669
47MP0005451_abnormal_body_composition1.51949293
48MP0003172_abnormal_lysosome_physiology1.51439964
49MP0002933_joint_inflammation1.43347778
50MP0003183_abnormal_peptide_metabolism1.41886789
51MP0003724_increased_susceptibility_to1.40248993
52MP0005174_abnormal_tail_pigmentation1.35925795
53MP0004381_abnormal_hair_follicle1.35909138
54MP0008961_abnormal_basal_metabolism1.34130829
55MP0001533_abnormal_skeleton_physiology1.28332168
56MP0000569_abnormal_digit_pigmentation1.26344356
57MP0008469_abnormal_protein_level1.17790009
58MP0005058_abnormal_lysosome_morphology1.17285686
59MP0004883_abnormal_blood_vessel1.14796890
60MP0003448_altered_tumor_morphology1.14567412
61MP0001851_eye_inflammation1.14101999
62MP0002277_abnormal_respiratory_mucosa1.13889506
63MP0000858_altered_metastatic_potential1.10834913
64MP0000490_abnormal_crypts_of1.09227836
65MP0005076_abnormal_cell_differentiation1.05947993
66MP0003191_abnormal_cellular_cholesterol1.01766237
67MP0003690_abnormal_glial_cell1.01401759
68MP0002019_abnormal_tumor_incidence0.89927504
69MP0003075_altered_response_to0.89319100
70MP0005164_abnormal_response_to0.87922649
71MP0010307_abnormal_tumor_latency0.87593704
72MP0010352_gastrointestinal_tract_polyps0.87445329
73MP0002998_abnormal_bone_remodeling0.87090560
74MP0000015_abnormal_ear_pigmentation0.86710260
75MP0005166_decreased_susceptibility_to0.85177504
76MP0005390_skeleton_phenotype0.84223624
77MP0008004_abnormal_stomach_pH0.81651111
78MP0003045_fibrosis0.79420804
79MP0002009_preneoplasia0.78705549
80MP0001986_abnormal_taste_sensitivity0.77736329
81MP0003656_abnormal_erythrocyte_physiolo0.75550562
82MP0001663_abnormal_digestive_system0.74927758
83MP0008874_decreased_physiological_sensi0.74468978
84MP0000343_altered_response_to0.71873550
85MP0004859_abnormal_synaptic_plasticity0.71133770
86MP0003828_pulmonary_edema0.69872650
87MP0009764_decreased_sensitivity_to0.69043699
88MP0000604_amyloidosis0.66994582
89MP0005075_abnormal_melanosome_morpholog0.65430586
90MP0003566_abnormal_cell_adhesion0.64791542
91MP0003091_abnormal_cell_migration0.62212582
92MP0008569_lethality_at_weaning0.59718712
93MP0003221_abnormal_cardiomyocyte_apopto0.58211394
94MP0003787_abnormal_imprinting0.57884317
95MP0002095_abnormal_skin_pigmentation0.57800131
96MP0002928_abnormal_bile_duct0.56833173
97MP0004130_abnormal_muscle_cell0.56104291
98MP0002138_abnormal_hepatobiliary_system0.55496057
99MP0003806_abnormal_nucleotide_metabolis0.53667534
100MP0005023_abnormal_wound_healing0.53364893
101MP0002136_abnormal_kidney_physiology0.52683583
102MP0000249_abnormal_blood_vessel0.52211435
103MP0009763_increased_sensitivity_to0.52078955
104MP0002693_abnormal_pancreas_physiology0.49953779
105MP0002332_abnormal_exercise_endurance0.49028781
106MP0002132_abnormal_respiratory_system0.48906866
107MP0008873_increased_physiological_sensi0.48647072
108MP0000313_abnormal_cell_death0.47222217
109MP0000371_diluted_coat_color0.47176337
110MP0005381_digestive/alimentary_phenotyp0.46043431
111MP0005621_abnormal_cell_physiology0.45587282
112MP0005319_abnormal_enzyme/_coenzyme0.45524593
113MP0002083_premature_death0.45063083
114MP0009840_abnormal_foam_cell0.44933042
115MP0000609_abnormal_liver_physiology0.43756955
116MP0003795_abnormal_bone_structure0.43436453
117MP0003453_abnormal_keratinocyte_physiol0.42336925
118MP0003077_abnormal_cell_cycle0.39071006
119MP0009765_abnormal_xenobiotic_induced0.38692940
120MP0004185_abnormal_adipocyte_glucose0.38243689

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.65718338
2Eczematoid dermatitis (HP:0000976)4.64810993
3Recurrent viral infections (HP:0004429)4.64610043
4Recurrent fungal infections (HP:0002841)4.63841613
5T lymphocytopenia (HP:0005403)4.53073442
6IgM deficiency (HP:0002850)4.41088449
7Panhypogammaglobulinemia (HP:0003139)4.36869560
8Abnormality of T cell number (HP:0011839)4.31590835
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.29010518
10Chronic otitis media (HP:0000389)4.27100706
11Recurrent bacterial skin infections (HP:0005406)4.11636244
12Recurrent bronchitis (HP:0002837)4.03695987
13Myositis (HP:0100614)3.94084621
14Cellulitis (HP:0100658)3.82247026
15Inflammation of the large intestine (HP:0002037)3.81016970
16Elevated erythrocyte sedimentation rate (HP:0003565)3.78724154
17Meningitis (HP:0001287)3.75646542
18Agammaglobulinemia (HP:0004432)3.74999819
19Gastrointestinal inflammation (HP:0004386)3.73659116
20Nasal polyposis (HP:0100582)3.67205400
21Recurrent cutaneous fungal infections (HP:0011370)3.66102105
22Chronic mucocutaneous candidiasis (HP:0002728)3.66102105
23Abnormality of T cells (HP:0002843)3.63647210
24Abnormality of the fingertips (HP:0001211)3.53221119
25Colitis (HP:0002583)3.48897708
26Papilloma (HP:0012740)3.46785881
27Verrucae (HP:0200043)3.46785881
28Thyroiditis (HP:0100646)3.33061200
29Abnormality of B cell number (HP:0010975)3.29796523
30B lymphocytopenia (HP:0010976)3.29796523
31Mediastinal lymphadenopathy (HP:0100721)3.28537769
32Urticaria (HP:0001025)3.25242724
33Pustule (HP:0200039)3.24032643
34Abnormality of the nasal mucosa (HP:0000433)3.23079190
35Recurrent skin infections (HP:0001581)3.22211316
36Spontaneous hematomas (HP:0007420)3.19772013
37Stomatitis (HP:0010280)3.15917620
38Keratoconjunctivitis (HP:0001096)3.14276817
39Chronic obstructive pulmonary disease (HP:0006510)3.10274819
40Obstructive lung disease (HP:0006536)3.10274819
41Vasculitis (HP:0002633)3.05013100
42Autoimmune thrombocytopenia (HP:0001973)3.02853673
43Severe combined immunodeficiency (HP:0004430)2.99862122
44Increased IgE level (HP:0003212)2.96755071
45Lymphopenia (HP:0001888)2.88980550
46Episodic fever (HP:0001954)2.85300050
47Hypochromic anemia (HP:0001931)2.83749253
48Prolonged bleeding time (HP:0003010)2.83558479
49Combined immunodeficiency (HP:0005387)2.83177251
50Hypochromic microcytic anemia (HP:0004840)2.81983011
51Eosinophilia (HP:0001880)2.78526219
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.78491749
53Abnormality of macrophages (HP:0004311)2.75760592
54Abnormality of T cell physiology (HP:0011840)2.74876591
55Optic neuritis (HP:0100653)2.70842245
56Retrobulbar optic neuritis (HP:0100654)2.70842245
57Orchitis (HP:0100796)2.68361286
58Recurrent gram-negative bacterial infections (HP:0005420)2.67516821
59Leukocytosis (HP:0001974)2.67212276
60Thrombocytosis (HP:0001894)2.66672107
61Chronic sinusitis (HP:0011109)2.59232673
62Increased IgM level (HP:0003496)2.58229756
63Abnormality of eosinophils (HP:0001879)2.56768478
64Recurrent sinusitis (HP:0011108)2.56442351
65Chest pain (HP:0100749)2.56213995
66Gastrointestinal stroma tumor (HP:0100723)2.52065867
67Encephalitis (HP:0002383)2.48808759
68Anorexia (HP:0002039)2.48405299
69Amyloidosis (HP:0011034)2.48253739
70IgG deficiency (HP:0004315)2.47612308
71Arterial thrombosis (HP:0004420)2.46417804
72Increased density of long bones (HP:0006392)2.43535694
73Granulocytopenia (HP:0001913)2.42443589
74Chronic diarrhea (HP:0002028)2.41225739
75Interstitial pulmonary disease (HP:0006530)2.36741125
76Periodontitis (HP:0000704)2.33420566
77Hemoptysis (HP:0002105)2.33035212
78Epistaxis (HP:0000421)2.31256525
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31128197
80Osteomyelitis (HP:0002754)2.30851958
81Pulmonary infiltrates (HP:0002113)2.29530175
82Impaired platelet aggregation (HP:0003540)2.26919016
83Abnormal platelet function (HP:0011869)2.26919016
84Petechiae (HP:0000967)2.25702181
85Gingivitis (HP:0000230)2.24726203
86Emphysema (HP:0002097)2.21915717
87Slow saccadic eye movements (HP:0000514)2.21694484
88Bronchitis (HP:0012387)2.19864469
89Abnormality of the pleura (HP:0002103)2.19692404
90Peritonitis (HP:0002586)2.19652780
91IgA deficiency (HP:0002720)2.16061816
92Loss of speech (HP:0002371)2.15433337
93Abnormality of glycolipid metabolism (HP:0010969)2.14851781
94Abnormality of liposaccharide metabolism (HP:0010968)2.14851781
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.14851781
96Increased serum ferritin (HP:0003281)2.14710124
97Microcytic anemia (HP:0001935)2.13569622
98Gangrene (HP:0100758)2.13251758
99Sepsis (HP:0100806)2.12951985
100Fatigue (HP:0012378)2.10449114
101Autoimmune hemolytic anemia (HP:0001890)2.09117448
102Viral hepatitis (HP:0006562)2.08572176
103Gingival bleeding (HP:0000225)2.06254432
104Purpura (HP:0000979)2.06132006
105Abnormal platelet volume (HP:0011876)2.04619122
106Lymphoma (HP:0002665)2.03884708
107Hepatosplenomegaly (HP:0001433)2.02156602
108Glomerulopathy (HP:0100820)2.01882857
109Premature loss of primary teeth (HP:0006323)2.01521123
110Abnormality of the peritoneum (HP:0002585)2.00550933
111Hematochezia (HP:0002573)2.00367084
112Skin ulcer (HP:0200042)1.97685545
113Abnormality of the endocardium (HP:0004306)1.96840658
114Dysostosis multiplex (HP:0000943)1.94151913
115Restrictive lung disease (HP:0002091)1.93340779
116Abnormality of iron homeostasis (HP:0011031)1.92900604
117Increased cerebral lipofuscin (HP:0011813)1.91834434
118Keratoconjunctivitis sicca (HP:0001097)1.91301361
119Basal cell carcinoma (HP:0002671)1.90462960
120Joint swelling (HP:0001386)1.89620915
121Increased neuronal autofluorescent lipopigment (HP:0002074)1.88184841
122Cheilitis (HP:0100825)1.85902728
123Acne (HP:0001061)1.85744743
124Pulmonary embolism (HP:0002204)1.78953289
125Recurrent otitis media (HP:0000403)1.78866395
126Hypergammaglobulinemia (HP:0010702)1.78582775
127Hypoplasia of the thymus (HP:0000778)1.77056458
128Papilledema (HP:0001085)1.76984833
129Gastrointestinal infarctions (HP:0005244)1.71790382
130Arthralgia (HP:0002829)1.71194622
131Hyperacusis (HP:0010780)1.71013538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.77145677
2PRPF4B3.18717789
3TXK3.00296952
4EEF2K2.83923687
5GRK62.71041370
6JAK32.54028569
7TYK22.43255285
8MAP3K102.42900001
9ZAP702.30429940
10STK102.27489707
11SIK22.10212794
12ITK2.06239704
13RIPK42.05840520
14FES1.99399401
15SYK1.95846105
16BTK1.95743641
17JAK11.93804470
18MAP3K131.92423760
19TRIB31.89269721
20MAP3K141.87858175
21PKN21.86982670
22BLK1.80653606
23CSF1R1.75980587
24HCK1.69360217
25MAP3K31.59016724
26EPHB11.56410532
27IKBKE1.55384390
28TBK11.54881438
29IRAK41.53043260
30LCK1.52121118
31CSK1.51989626
32MAP3K111.50336452
33KIT1.47813892
34ERN11.44832165
35TGFBR21.41291523
36FGFR41.38129411
37FGFR31.34675867
38CLK11.34113750
39TEC1.32611190
40LRRK21.32420963
41CDK121.30620035
42MAP3K11.22531829
43TNK21.17069588
44MARK31.13074938
45PRKCH1.10994593
46MAP2K31.07391188
47ALK1.04947879
48JAK21.04632199
49MAP3K71.02130549
50IKBKB0.99753056
51SMG10.99412696
52PIM10.97924444
53TAOK20.96252275
54SIK30.93983792
55LYN0.93958845
56YES10.90697178
57IRAK10.90496576
58PDK10.88460941
59TAOK10.88191296
60MATK0.85428660
61IRAK20.84888918
62BMPR20.83734726
63SIK10.83455013
64PRKCQ0.83183915
65NLK0.82259775
66CDC42BPA0.80972499
67IRAK30.75450229
68PTK60.72919753
69TTN0.69368939
70CDK40.68512031
71CAMK1G0.67659383
72CHUK0.64180675
73MARK20.62243889
74RPS6KA40.62104013
75HIPK20.61656846
76SGK30.59331550
77CAMK1D0.59104442
78TAOK30.57770990
79MAP3K60.54752725
80FLT30.53561366
81MAPK40.52347114
82CAMKK10.52058353
83NEK20.51602095
84MAPK120.49487514
85RPS6KC10.48864826
86RPS6KL10.48864826
87DAPK10.48322254
88TESK20.47360678
89CAMKK20.46010092
90FGR0.45361767
91PIK3CG0.44477149
92PRKD20.43516991
93TRPM70.43383311
94DYRK1B0.41987211
95FYN0.41638361
96MAP3K90.40921767
97MAPK70.40533489
98STK110.39894075
99MAP3K50.39324876
100RET0.39130142
101DMPK0.38760863
102STK40.38551839
103CDK190.38413714
104STK380.37383217
105PTK2B0.37354125
106PDPK10.37114007
107CDK90.36397277
108KSR20.35763869
109DAPK20.35513988
110CDK60.35412963
111MAP2K60.35168206
112MAP3K20.35012406
113GRK70.34984469
114RPS6KA60.34635082
115PDGFRB0.33694794
116BRD40.33686134
117RIPK10.31492910
118EPHA30.31112096
119EGFR0.31019980
120RAF10.29854578
121MAPKAPK20.29026654
122ABL10.27772255
123CAMK40.27375092
124MAP3K80.27135353
125MAPK110.26680378
126SCYL20.26633130

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.74670600
2B cell receptor signaling pathway_Homo sapiens_hsa046622.95265414
3T cell receptor signaling pathway_Homo sapiens_hsa046602.50442687
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.47366656
5Osteoclast differentiation_Homo sapiens_hsa043802.46501229
6Leishmaniasis_Homo sapiens_hsa051402.42049548
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19415039
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.10736658
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.07296725
10Measles_Homo sapiens_hsa051622.02794915
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.99433616
12Antigen processing and presentation_Homo sapiens_hsa046121.89773875
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.84777669
14Hematopoietic cell lineage_Homo sapiens_hsa046401.82125705
15Chemokine signaling pathway_Homo sapiens_hsa040621.69414180
16Acute myeloid leukemia_Homo sapiens_hsa052211.57902170
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.54264225
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53848569
19Graft-versus-host disease_Homo sapiens_hsa053321.46963073
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42600601
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42489152
22Toxoplasmosis_Homo sapiens_hsa051451.40953470
23Tuberculosis_Homo sapiens_hsa051521.40724627
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.39435440
25Chronic myeloid leukemia_Homo sapiens_hsa052201.38478933
26Allograft rejection_Homo sapiens_hsa053301.34656889
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34563708
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33647608
29Shigellosis_Homo sapiens_hsa051311.32650357
30Platelet activation_Homo sapiens_hsa046111.32055255
31Hepatitis B_Homo sapiens_hsa051611.30954338
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27249656
33Herpes simplex infection_Homo sapiens_hsa051681.24347189
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.23309899
35Influenza A_Homo sapiens_hsa051641.22003488
36Pancreatic cancer_Homo sapiens_hsa052121.19040010
37Staphylococcus aureus infection_Homo sapiens_hsa051501.17168931
38TNF signaling pathway_Homo sapiens_hsa046681.16459043
39Non-small cell lung cancer_Homo sapiens_hsa052231.15913526
40Viral myocarditis_Homo sapiens_hsa054161.15629184
41Phagosome_Homo sapiens_hsa041451.15141259
42VEGF signaling pathway_Homo sapiens_hsa043701.12803226
43Pertussis_Homo sapiens_hsa051331.07031566
44Apoptosis_Homo sapiens_hsa042101.06419764
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02171892
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02055609
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96664732
48Salmonella infection_Homo sapiens_hsa051320.95212712
49Legionellosis_Homo sapiens_hsa051340.92518835
50Prolactin signaling pathway_Homo sapiens_hsa049170.91826557
51Colorectal cancer_Homo sapiens_hsa052100.88236017
52Malaria_Homo sapiens_hsa051440.85179036
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83750078
54HTLV-I infection_Homo sapiens_hsa051660.83563420
55Epstein-Barr virus infection_Homo sapiens_hsa051690.82043175
56Asthma_Homo sapiens_hsa053100.80716688
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79069555
58Hepatitis C_Homo sapiens_hsa051600.76044747
59Other glycan degradation_Homo sapiens_hsa005110.75254424
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75062148
61Endocytosis_Homo sapiens_hsa041440.74838316
62Type I diabetes mellitus_Homo sapiens_hsa049400.74742576
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74389554
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73329905
65MAPK signaling pathway_Homo sapiens_hsa040100.73191575
66Glioma_Homo sapiens_hsa052140.70825896
67mTOR signaling pathway_Homo sapiens_hsa041500.69307906
68Long-term potentiation_Homo sapiens_hsa047200.67075725
69Viral carcinogenesis_Homo sapiens_hsa052030.66687123
70Inositol phosphate metabolism_Homo sapiens_hsa005620.66465604
71GnRH signaling pathway_Homo sapiens_hsa049120.66175163
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.66046410
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.65391425
74Autoimmune thyroid disease_Homo sapiens_hsa053200.65311912
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64279909
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63165505
77Renal cell carcinoma_Homo sapiens_hsa052110.62660206
78Type II diabetes mellitus_Homo sapiens_hsa049300.61538114
79FoxO signaling pathway_Homo sapiens_hsa040680.60897330
80HIF-1 signaling pathway_Homo sapiens_hsa040660.59873216
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58886707
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57746756
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.57719608
84Olfactory transduction_Homo sapiens_hsa047400.57632370
85African trypanosomiasis_Homo sapiens_hsa051430.57133392
86Notch signaling pathway_Homo sapiens_hsa043300.56802503
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56075754
88Choline metabolism in cancer_Homo sapiens_hsa052310.54989896
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54805008
90Insulin resistance_Homo sapiens_hsa049310.54600455
91Amoebiasis_Homo sapiens_hsa051460.54306871
92Rheumatoid arthritis_Homo sapiens_hsa053230.54306799
93Dorso-ventral axis formation_Homo sapiens_hsa043200.53535409
94Lysosome_Homo sapiens_hsa041420.52111757
95Estrogen signaling pathway_Homo sapiens_hsa049150.51705536
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51588056
97Rap1 signaling pathway_Homo sapiens_hsa040150.51016487
98Endometrial cancer_Homo sapiens_hsa052130.50244104
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46680029
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46222245
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44411962
102Gastric acid secretion_Homo sapiens_hsa049710.43929520
103Oxytocin signaling pathway_Homo sapiens_hsa049210.43691476
104ErbB signaling pathway_Homo sapiens_hsa040120.43219496
105Small cell lung cancer_Homo sapiens_hsa052220.42117958
106Prostate cancer_Homo sapiens_hsa052150.42019904
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41863176
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.40583480
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.40132604
110Regulation of autophagy_Homo sapiens_hsa041400.39533596

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