FMNL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.49042311
2central nervous system myelination (GO:0022010)5.49042311
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.65358168
4cellular potassium ion homeostasis (GO:0030007)4.61018256
5sodium ion export (GO:0071436)4.23688616
6glutamate secretion (GO:0014047)4.14003738
7neurotransmitter-gated ion channel clustering (GO:0072578)4.03254404
8postsynaptic membrane organization (GO:0001941)3.99455551
9L-amino acid import (GO:0043092)3.95221080
10amino acid import (GO:0043090)3.86808340
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.68732843
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67225595
13ensheathment of neurons (GO:0007272)3.60315256
14axon ensheathment (GO:0008366)3.60315256
15myelination (GO:0042552)3.58529744
16cellular sodium ion homeostasis (GO:0006883)3.42707945
17regulation of neuronal synaptic plasticity (GO:0048168)3.42094672
18negative regulation of neurotransmitter secretion (GO:0046929)3.41108570
19synaptic vesicle exocytosis (GO:0016079)3.37788015
20regulation of synaptic vesicle exocytosis (GO:2000300)3.36587942
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36533548
22cytoskeletal anchoring at plasma membrane (GO:0007016)3.34819315
23vocalization behavior (GO:0071625)3.33394309
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.26645392
25asymmetric protein localization (GO:0008105)3.24728927
26potassium ion homeostasis (GO:0055075)3.24062514
27positive regulation of dendritic spine morphogenesis (GO:0061003)3.21982092
28response to lipoprotein particle (GO:0055094)3.21801746
29membrane assembly (GO:0071709)3.21075949
30positive regulation of dendritic spine development (GO:0060999)3.19122121
31neuronal action potential propagation (GO:0019227)3.16346377
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15831650
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.14060504
34neuromuscular process controlling balance (GO:0050885)3.12905844
35dendrite morphogenesis (GO:0048813)3.08374717
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07576021
37nerve growth factor signaling pathway (GO:0038180)3.05627531
38positive regulation of synapse maturation (GO:0090129)3.03943583
39negative regulation of neurotransmitter transport (GO:0051589)3.03218262
40exploration behavior (GO:0035640)3.02838505
41negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.02391359
42protein localization to synapse (GO:0035418)3.01192811
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.00026962
44axonal fasciculation (GO:0007413)2.98075475
45cell communication by electrical coupling (GO:0010644)2.97768523
46presynaptic membrane organization (GO:0097090)2.97355197
47positive regulation of actin filament depolymerization (GO:0030836)2.93815537
48dendritic spine morphogenesis (GO:0060997)2.93192865
49import into cell (GO:0098657)2.92164548
50regulation of glutamate receptor signaling pathway (GO:1900449)2.91417524
51potassium ion import (GO:0010107)2.90325352
52apical protein localization (GO:0045176)2.88626436
53myelin maintenance (GO:0043217)2.86463316
54lateral sprouting from an epithelium (GO:0060601)2.86042606
55regulation of synaptic vesicle transport (GO:1902803)2.81617995
56semaphorin-plexin signaling pathway (GO:0071526)2.80967841
57myelination in peripheral nervous system (GO:0022011)2.80219558
58peripheral nervous system axon ensheathment (GO:0032292)2.80219558
59locomotory exploration behavior (GO:0035641)2.79787814
60embryonic retina morphogenesis in camera-type eye (GO:0060059)2.76126381
61Rap protein signal transduction (GO:0032486)2.74898705
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74204503
63neurotransmitter secretion (GO:0007269)2.73942161
64presynaptic membrane assembly (GO:0097105)2.71874685
65neuron recognition (GO:0008038)2.71707400
66growth hormone receptor signaling pathway (GO:0060396)2.69663809
67negative regulation of dendrite morphogenesis (GO:0050774)2.66898000
68cerebral cortex radially oriented cell migration (GO:0021799)2.66211188
69synaptic vesicle maturation (GO:0016188)2.65830559
70negative regulation of axon extension involved in axon guidance (GO:0048843)2.62844556
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62751623
72regulation of axon extension involved in axon guidance (GO:0048841)2.61953546
73acidic amino acid transport (GO:0015800)2.61806857
74regulation of dendritic spine morphogenesis (GO:0061001)2.61140500
75long-chain fatty acid biosynthetic process (GO:0042759)2.60000379
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57502428
77positive regulation of dendrite development (GO:1900006)2.56326042
78eye photoreceptor cell differentiation (GO:0001754)2.56285550
79photoreceptor cell differentiation (GO:0046530)2.56285550
80astrocyte differentiation (GO:0048708)2.55949523
81cell communication involved in cardiac conduction (GO:0086065)2.55611593
82regulation of synaptic plasticity (GO:0048167)2.53772237
83positive regulation of neurological system process (GO:0031646)2.53109279
84glutamate receptor signaling pathway (GO:0007215)2.52219635
85synaptic transmission, glutamatergic (GO:0035249)2.52062586
86mating behavior (GO:0007617)2.52053450
87hemidesmosome assembly (GO:0031581)2.51983984
88neurotransmitter uptake (GO:0001504)2.51875130
89regulation of axon guidance (GO:1902667)2.50974436
90C4-dicarboxylate transport (GO:0015740)2.49538891
91regulation of synapse maturation (GO:0090128)2.49426326
92regulation of dendritic spine development (GO:0060998)2.48808360
93cytoplasmic mRNA processing body assembly (GO:0033962)2.46506795
94peptidyl-tyrosine autophosphorylation (GO:0038083)2.46216933
95negative regulation of axon guidance (GO:1902668)2.45714839
96auditory behavior (GO:0031223)2.45497013
97negative regulation of axon extension (GO:0030517)2.45350772
98response to methylmercury (GO:0051597)2.42975179
99central nervous system projection neuron axonogenesis (GO:0021952)2.40075314
100L-glutamate transport (GO:0015813)2.39715143
101layer formation in cerebral cortex (GO:0021819)2.39420743
102negative regulation of protein localization to cell surface (GO:2000009)2.38806176
103response to auditory stimulus (GO:0010996)2.38207163
104cerebellar Purkinje cell layer development (GO:0021680)2.37133241
105long-term memory (GO:0007616)2.36633589
106cellular response to growth hormone stimulus (GO:0071378)2.36481919
107establishment of mitochondrion localization (GO:0051654)2.35504754
108regulation of ARF protein signal transduction (GO:0032012)2.35452687
109oligodendrocyte differentiation (GO:0048709)2.34948549
110neurotransmitter transport (GO:0006836)2.34025854
111cholesterol biosynthetic process (GO:0006695)2.34014790
112negative regulation of axonogenesis (GO:0050771)2.33005013
113neuron cell-cell adhesion (GO:0007158)2.32620981
114regulation of synapse structural plasticity (GO:0051823)2.32278369
115paraxial mesoderm development (GO:0048339)2.31788550
116establishment of nucleus localization (GO:0040023)2.29548475
117adult walking behavior (GO:0007628)2.28715437
118ganglion development (GO:0061548)2.28634508
119neuronal ion channel clustering (GO:0045161)2.28182203
120regulation of cholesterol biosynthetic process (GO:0045540)2.27761587
121gamma-aminobutyric acid transport (GO:0015812)2.27725028
122synaptic vesicle endocytosis (GO:0048488)2.27522023
123fatty acid elongation (GO:0030497)2.27457069
124positive regulation of membrane potential (GO:0045838)2.26994113
125regulation of excitatory postsynaptic membrane potential (GO:0060079)2.26910707
126regulation of dendrite morphogenesis (GO:0048814)2.25854473
127positive regulation of oligodendrocyte differentiation (GO:0048714)2.23970609
128regulation of collateral sprouting (GO:0048670)2.20950993
129negative regulation of JUN kinase activity (GO:0043508)2.20860179
130limb bud formation (GO:0060174)2.20712554
131polarized epithelial cell differentiation (GO:0030859)2.20580902
132prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.19373839
133lens fiber cell development (GO:0070307)2.17495847
134cellular response to nerve growth factor stimulus (GO:1990090)2.17053264
135response to nerve growth factor (GO:1990089)2.17053264
136establishment of cell polarity (GO:0030010)2.14912041
137cellular response to cholesterol (GO:0071397)2.14676800
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.13141309
139protein localization to endosome (GO:0036010)2.12770388
140craniofacial suture morphogenesis (GO:0097094)2.11519776
141regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.10581912
142regulation of dendritic cell antigen processing and presentation (GO:0002604)2.09507566
143interleukin-6-mediated signaling pathway (GO:0070102)2.08999721
144substrate-independent telencephalic tangential migration (GO:0021826)2.08974681
145substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.08974681
146cerebellar granule cell differentiation (GO:0021707)2.08719957
147chondrocyte development (GO:0002063)2.08058394
148camera-type eye morphogenesis (GO:0048593)2.06667172
149platelet-derived growth factor receptor signaling pathway (GO:0048008)2.06442429
150regulation of neuron migration (GO:2001222)2.06398855
151establishment of epithelial cell polarity (GO:0090162)2.06176408
152central nervous system neuron axonogenesis (GO:0021955)2.05790855
153neuroblast proliferation (GO:0007405)2.05255207
154hippo signaling (GO:0035329)2.04859099
155negative regulation of exocytosis (GO:0045920)2.04724667
156enteric nervous system development (GO:0048484)2.04662154
157sterol biosynthetic process (GO:0016126)2.03951695
158regulation of oligodendrocyte differentiation (GO:0048713)2.03820634
159mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.03584815
160dendritic spine organization (GO:0097061)2.03238289
161astrocyte development (GO:0014002)2.03227320
162adhesion of symbiont to host cell (GO:0044650)2.00464725
163virion attachment to host cell (GO:0019062)2.00464725
164branching involved in prostate gland morphogenesis (GO:0060442)2.00357961
165regulation of respiratory system process (GO:0044065)2.00324594
166dermatan sulfate biosynthetic process (GO:0030208)1.99340729
167kidney morphogenesis (GO:0060993)1.99024939
168regulation of branching involved in salivary gland morphogenesis (GO:0060693)1.98729207
169regulation of respiratory gaseous exchange (GO:0043576)1.97915789
170positive regulation of protein depolymerization (GO:1901881)1.97031896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29092640
2GBX2_23144817_ChIP-Seq_PC3_Human2.23526219
3EZH2_22144423_ChIP-Seq_EOC_Human2.12730845
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09095321
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05821200
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05255318
7RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97433734
8EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97433734
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90274819
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88493415
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88467567
12WT1_19549856_ChIP-ChIP_CCG9911_Human1.88384652
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87845643
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86378027
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86191968
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83592915
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.80965810
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.80915942
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.80417451
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.80222312
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76119476
22AR_21572438_ChIP-Seq_LNCaP_Human1.75995661
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.74849772
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.71200845
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71111641
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70330394
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70007678
28REST_21632747_ChIP-Seq_MESCs_Mouse1.68114711
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.66937713
30* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66790381
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61688248
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60885988
33* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55225311
34* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55225311
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54897647
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54858381
37TP53_16413492_ChIP-PET_HCT116_Human1.53888311
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52594348
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52435478
40AHR_22903824_ChIP-Seq_MCF-7_Human1.52186297
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.50458534
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48988907
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46361882
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.45388467
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45115621
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44233811
47DROSHA_22980978_ChIP-Seq_HELA_Human1.42660176
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41528260
49* FOXA2_19822575_ChIP-Seq_HepG2_Human1.41225886
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.40384692
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.39548466
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.37060879
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34829480
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34562243
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34011543
56* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33948132
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33389785
58P300_19829295_ChIP-Seq_ESCs_Human1.31572457
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.31081092
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29259780
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26921196
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26684256
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.24526224
64SMAD4_21799915_ChIP-Seq_A2780_Human1.24168413
65* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23403655
66TP53_18474530_ChIP-ChIP_U2OS_Human1.22824187
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.22267929
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19771178
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.19689746
70* KDM2B_26808549_Chip-Seq_K562_Human1.19134034
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18838399
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.18746258
73* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17921150
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17641655
75AR_19668381_ChIP-Seq_PC3_Human1.17295920
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17248391
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16921118
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16012607
79STAT3_23295773_ChIP-Seq_U87_Human1.15902927
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14673246
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14493138
82FUS_26573619_Chip-Seq_HEK293_Human1.14127665
83* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13992881
84CLOCK_20551151_ChIP-Seq_293T_Human1.13598879
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12517276
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12015517
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11741873
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.11615224
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.11450449
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11437958
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11388815
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11245284
93* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10905116
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10368640
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10179378
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08762138
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08507416
98ER_23166858_ChIP-Seq_MCF-7_Human1.07862115
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07579509
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07354307
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.07346579
102* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07253610
103RXR_22108803_ChIP-Seq_LS180_Human1.07101524
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.06961473
105SOX9_26525672_Chip-Seq_HEART_Mouse1.06420019
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06333892
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05350556
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05350556
109* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04533440
110TAF15_26573619_Chip-Seq_HEK293_Human1.03845107
111VDR_24787735_ChIP-Seq_THP-1_Human1.03499626
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02763447
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02650112
114* SOX2_21211035_ChIP-Seq_LN229_Gbm1.01924527
115* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01736060
116CJUN_26792858_Chip-Seq_BT549_Human1.01408113
117RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00583696
118TCF4_18268006_ChIP-ChIP_LS174T_Human1.00230826
119IGF1R_20145208_ChIP-Seq_DFB_Human1.00078904
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.99905611
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98961368
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96862670
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96389009
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.94922396
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94675768
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94216416
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93644939
128AR_25329375_ChIP-Seq_VCAP_Human0.93355214
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.93216563
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.93066967
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92375148
132* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91856313
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91715027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland3.09615913
2MP0002254_reproductive_system_inflammat3.00374393
3MP0000778_abnormal_nervous_system2.91553561
4MP0005171_absent_coat_pigmentation2.86385834
5MP0000920_abnormal_myelination2.80791318
6MP0005623_abnormal_meninges_morphology2.56063879
7MP0004885_abnormal_endolymph2.40274509
8MP0003122_maternal_imprinting2.32188581
9MP0001299_abnormal_eye_distance/2.26450400
10MP0001348_abnormal_lacrimal_gland2.19712759
11MP0004270_analgesia2.02447699
12MP0000579_abnormal_nail_morphology1.98282735
13MP0002877_abnormal_melanocyte_morpholog1.92863370
14MP0003690_abnormal_glial_cell1.91088142
15MP0009250_abnormal_appendicular_skeleto1.83638079
16MP0009780_abnormal_chondrocyte_physiolo1.83403708
17MP0003880_abnormal_central_pattern1.83229369
18MP0003634_abnormal_glial_cell1.79904870
19MP0003123_paternal_imprinting1.79406213
20MP0004859_abnormal_synaptic_plasticity1.79366333
21MP0003937_abnormal_limbs/digits/tail_de1.76816136
22MP0010678_abnormal_skin_adnexa1.76095613
23MP0004858_abnormal_nervous_system1.73636371
24MP0005409_darkened_coat_color1.73396614
25MP0010030_abnormal_orbit_morphology1.68169394
26MP0004134_abnormal_chest_morphology1.65588622
27MP0005248_abnormal_Harderian_gland1.65061254
28MP0001984_abnormal_olfaction1.61335806
29MP0000569_abnormal_digit_pigmentation1.58746067
30MP0003385_abnormal_body_wall1.54797694
31MP0000383_abnormal_hair_follicle1.54742667
32MP0002938_white_spotting1.52254612
33MP0001485_abnormal_pinna_reflex1.52079917
34MP0000534_abnormal_ureter_morphology1.51653701
35MP0004272_abnormal_basement_membrane1.43427189
36MP0004811_abnormal_neuron_physiology1.41551521
37MP0003950_abnormal_plasma_membrane1.41312017
38MP0005187_abnormal_penis_morphology1.40773195
39MP0005367_renal/urinary_system_phenotyp1.39981491
40MP0000516_abnormal_urinary_system1.39981491
41MP0005167_abnormal_blood-brain_barrier1.39881754
42MP0001486_abnormal_startle_reflex1.37714970
43MP0000604_amyloidosis1.37275991
44MP0008438_abnormal_cutaneous_collagen1.35995145
45MP0003879_abnormal_hair_cell1.35306616
46MP0000733_abnormal_muscle_development1.35051131
47MP0004742_abnormal_vestibular_system1.33610534
48MP0005423_abnormal_somatic_nervous1.33199999
49MP0003755_abnormal_palate_morphology1.32774086
50MP0003632_abnormal_nervous_system1.29211091
51MP0000428_abnormal_craniofacial_morphol1.27943291
52MP0000462_abnormal_digestive_system1.26405900
53MP0003705_abnormal_hypodermis_morpholog1.25700194
54MP0003136_yellow_coat_color1.23969508
55MP0000537_abnormal_urethra_morphology1.23519448
56MP0003635_abnormal_synaptic_transmissio1.23131533
57MP0002067_abnormal_sensory_capabilities1.22634721
58MP0003942_abnormal_urinary_system1.21792810
59MP0001501_abnormal_sleep_pattern1.21552501
60MP0010368_abnormal_lymphatic_system1.21343194
61MP0003091_abnormal_cell_migration1.20649181
62MP0005257_abnormal_intraocular_pressure1.19904439
63MP0005503_abnormal_tendon_morphology1.18596625
64MP0002233_abnormal_nose_morphology1.18288162
65MP0000647_abnormal_sebaceous_gland1.17198582
66MP0002064_seizures1.16983598
67MP0002734_abnormal_mechanical_nocicepti1.16821889
68MP0000955_abnormal_spinal_cord1.16393676
69MP0000566_synostosis1.14850359
70MP0002089_abnormal_postnatal_growth/wei1.14733794
71MP0002735_abnormal_chemical_nociception1.14715806
72MP0001440_abnormal_grooming_behavior1.12481022
73MP0008789_abnormal_olfactory_epithelium1.11919635
74MP0002557_abnormal_social/conspecific_i1.11606122
75MP0000762_abnormal_tongue_morphology1.11332770
76MP0001293_anophthalmia1.08721374
77MP0001177_atelectasis1.08385354
78MP0002063_abnormal_learning/memory/cond1.08341858
79MP0002066_abnormal_motor_capabilities/c1.08292333
80MP0002272_abnormal_nervous_system1.07542475
81MP0002116_abnormal_craniofacial_bone1.07001453
82MP0002882_abnormal_neuron_morphology1.06893956
83MP0000049_abnormal_middle_ear1.06799750
84MP0001502_abnormal_circadian_rhythm1.06207048
85MP0002896_abnormal_bone_mineralization1.03989031
86MP0002229_neurodegeneration1.00991291
87MP0009053_abnormal_anal_canal1.00317134
88MP0001970_abnormal_pain_threshold0.99225803
89MP0003303_peritoneal_inflammation0.98933793
90MP0000613_abnormal_salivary_gland0.98727064
91MP0003861_abnormal_nervous_system0.98135959
92MP0000432_abnormal_head_morphology0.96754490
93MP0004924_abnormal_behavior0.95794060
94MP0005386_behavior/neurological_phenoty0.95794060
95MP0001915_intracranial_hemorrhage0.95627663
96MP0002177_abnormal_outer_ear0.95019300
97MP0002152_abnormal_brain_morphology0.92591157
98MP0001968_abnormal_touch/_nociception0.92523175
99MP0003631_nervous_system_phenotype0.92409632
100MP0003941_abnormal_skin_development0.92112168
101MP0003566_abnormal_cell_adhesion0.91152239
102MP0004510_myositis0.89562996
103MP0005197_abnormal_uvea_morphology0.89491025
104MP0003329_amyloid_beta_deposits0.89394237
105MP0009745_abnormal_behavioral_response0.89219188
106MP0005645_abnormal_hypothalamus_physiol0.87614461
107MP0003121_genomic_imprinting0.87358990
108MP0005499_abnormal_olfactory_system0.86975343
109MP0005394_taste/olfaction_phenotype0.86975343
110MP0005508_abnormal_skeleton_morphology0.86540286
111MP0003633_abnormal_nervous_system0.85737024
112MP0002295_abnormal_pulmonary_circulatio0.85674891
113MP0003935_abnormal_craniofacial_develop0.85270355
114MP0005646_abnormal_pituitary_gland0.85132315
115MP0002184_abnormal_innervation0.84143666
116MP0001340_abnormal_eyelid_morphology0.84110824
117MP0005076_abnormal_cell_differentiation0.83139276
118MP0002092_abnormal_eye_morphology0.82781341
119MP0002733_abnormal_thermal_nociception0.81660899
120MP0001958_emphysema0.81308908
121MP0000631_abnormal_neuroendocrine_gland0.81294845
122MP0009046_muscle_twitch0.80858695
123MP0003938_abnormal_ear_development0.80441036
124MP0002249_abnormal_larynx_morphology0.78962027
125MP0000163_abnormal_cartilage_morphology0.78858452
126MP0000372_irregular_coat_pigmentation0.77620800
127MP0003183_abnormal_peptide_metabolism0.77504676
128MP0001963_abnormal_hearing_physiology0.77011680
129MP0003890_abnormal_embryonic-extraembry0.75969043
130MP0002752_abnormal_somatic_nervous0.75795002
131MP0008569_lethality_at_weaning0.75596420
132MP0002572_abnormal_emotion/affect_behav0.75527396
133MP0002697_abnormal_eye_size0.75459549
134MP0002909_abnormal_adrenal_gland0.74181354
135MP0001849_ear_inflammation0.73159961
136MP0003868_abnormal_feces_composition0.71167612
137MP0001529_abnormal_vocalization0.71062516
138MP0003115_abnormal_respiratory_system0.67562480
139MP0005551_abnormal_eye_electrophysiolog0.67260570
140MP0005023_abnormal_wound_healing0.67103579
141MP0006276_abnormal_autonomic_nervous0.63601787

Predicted human phenotypes

RankGene SetZ-score
1Scanning speech (HP:0002168)3.92259065
2Focal motor seizures (HP:0011153)3.73060946
3Myokymia (HP:0002411)3.55117620
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.54569001
5Degeneration of the lateral corticospinal tracts (HP:0002314)3.54569001
6Neurofibrillary tangles (HP:0002185)3.50538755
7Focal seizures (HP:0007359)3.39983492
8Megalencephaly (HP:0001355)3.16146675
9Insidious onset (HP:0003587)3.15995248
10Termporal pattern (HP:0011008)3.15995248
11Abnormality of the corticospinal tract (HP:0002492)3.01147264
12Coronal craniosynostosis (HP:0004440)2.88676779
13Alacrima (HP:0000522)2.73614654
14Aplasia involving bones of the upper limbs (HP:0009823)2.72577775
15Aplasia of the phalanges of the hand (HP:0009802)2.72577775
16Aplasia involving bones of the extremities (HP:0009825)2.72577775
17Cerebral inclusion bodies (HP:0100314)2.65589860
18Segmental peripheral demyelination/remyelination (HP:0003481)2.58557850
19Onion bulb formation (HP:0003383)2.58069575
20Buphthalmos (HP:0000557)2.54545529
21Insomnia (HP:0100785)2.54001182
22Abnormality of binocular vision (HP:0011514)2.53742393
23Diplopia (HP:0000651)2.53742393
24Shallow orbits (HP:0000586)2.51523747
25Atonic seizures (HP:0010819)2.50686121
26Abnormality of the nasal septum (HP:0000419)2.49212271
27Peripheral hypomyelination (HP:0007182)2.48186192
28Epileptic encephalopathy (HP:0200134)2.48111458
29Stomach cancer (HP:0012126)2.45573641
30Action tremor (HP:0002345)2.44975756
31Febrile seizures (HP:0002373)2.42931023
32Anteriorly placed anus (HP:0001545)2.35548054
33Supranuclear gaze palsy (HP:0000605)2.33983854
34Dysmetria (HP:0001310)2.27583721
35Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.26191952
36Cupped ear (HP:0000378)2.22745656
37Urinary bladder sphincter dysfunction (HP:0002839)2.18799533
38Turricephaly (HP:0000262)2.17799099
39Renal duplication (HP:0000075)2.14781936
40Excessive salivation (HP:0003781)2.12901535
41Drooling (HP:0002307)2.12901535
42Obstructive sleep apnea (HP:0002870)2.12670890
43Abnormality of the middle phalanges of the toes (HP:0010183)2.10137126
44Macroorchidism (HP:0000053)2.09402789
45Protrusio acetabuli (HP:0003179)2.07756498
46Abnormality of the parietal bone (HP:0002696)2.06868195
47Generalized tonic-clonic seizures (HP:0002069)2.06250670
48Thickened helices (HP:0000391)2.04235676
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02813559
50Short 4th metacarpal (HP:0010044)2.02813559
51Decreased lacrimation (HP:0000633)2.02205141
52Arterial tortuosity (HP:0005116)2.01030478
53Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00916396
54Deep venous thrombosis (HP:0002625)1.99891811
55Cerebral aneurysm (HP:0004944)1.99604696
56Aqueductal stenosis (HP:0002410)1.97633183
57Retinal dysplasia (HP:0007973)1.96804475
58Hypoplasia of the iris (HP:0007676)1.96274342
59Mixed hearing impairment (HP:0000410)1.95154441
60Apathy (HP:0000741)1.93946626
61Large earlobe (HP:0009748)1.92962405
62Midline defect of the nose (HP:0004122)1.92453224
63Microglossia (HP:0000171)1.91617787
64Hyperacusis (HP:0010780)1.91426568
65Urinary urgency (HP:0000012)1.90835487
66Esophageal atresia (HP:0002032)1.89956172
67Atrophic scars (HP:0001075)1.89842890
68Hepatoblastoma (HP:0002884)1.85613396
69Renovascular hypertension (HP:0100817)1.85284825
70Abnormal auditory evoked potentials (HP:0006958)1.84125324
71Truncal ataxia (HP:0002078)1.83899694
72Cutaneous syndactyly (HP:0012725)1.83862308
73Neuronal loss in central nervous system (HP:0002529)1.83054096
74Ulnar claw (HP:0001178)1.83008332
75Intention tremor (HP:0002080)1.82724052
76Torticollis (HP:0000473)1.81776016
77Akinesia (HP:0002304)1.79153072
78Vascular tortuosity (HP:0004948)1.78844818
79Bronchomalacia (HP:0002780)1.78370664
80Arnold-Chiari malformation (HP:0002308)1.78277732
81Papillary thyroid carcinoma (HP:0002895)1.78185494
82Neonatal short-limb short stature (HP:0008921)1.77448538
83Abnormality of salivation (HP:0100755)1.76918080
84Postural instability (HP:0002172)1.73829405
85Postural tremor (HP:0002174)1.73466033
86Trigonocephaly (HP:0000243)1.72791474
87Complement deficiency (HP:0004431)1.72387334
88Relative macrocephaly (HP:0004482)1.71580020
89Absent speech (HP:0001344)1.71003195
90Myelomeningocele (HP:0002475)1.70396647
91Intellectual disability, moderate (HP:0002342)1.70211176
92Choanal stenosis (HP:0000452)1.70191084
93Spastic gait (HP:0002064)1.69410443
94Absence seizures (HP:0002121)1.69298986
95Dialeptic seizures (HP:0011146)1.68041221
96Epidermoid cyst (HP:0200040)1.67641343
97Spastic tetraparesis (HP:0001285)1.67344639
98Ankle clonus (HP:0011448)1.67276563
99Abnormal eating behavior (HP:0100738)1.67168619
100Bifid scrotum (HP:0000048)1.66771734
101Broad metatarsal (HP:0001783)1.66187610
102Impaired vibration sensation in the lower limbs (HP:0002166)1.66181021
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.66056621
104Osteolytic defects of the hand bones (HP:0009699)1.66056621
105Elfin facies (HP:0004428)1.65729877
106Bell-shaped thorax (HP:0001591)1.65211698
107Progressive cerebellar ataxia (HP:0002073)1.64388992
108Humeroradial synostosis (HP:0003041)1.62608326
109Synostosis involving the elbow (HP:0003938)1.62608326
110Abnormality of the lower motor neuron (HP:0002366)1.62278614
111Septo-optic dysplasia (HP:0100842)1.62148221
112Diminished motivation (HP:0000745)1.61846656
113Sensory axonal neuropathy (HP:0003390)1.61741206
114Broad ribs (HP:0000885)1.61282402
115Congenital glaucoma (HP:0001087)1.61241546
116Dysdiadochokinesis (HP:0002075)1.60687548
117Small epiphyses (HP:0010585)1.60575761
118Stenosis of the external auditory canal (HP:0000402)1.60179610
119Infantile muscular hypotonia (HP:0008947)1.60073771
120White forelock (HP:0002211)1.60024221
121Absent septum pellucidum (HP:0001331)1.59024186
122Overriding aorta (HP:0002623)1.58466135
123Mutism (HP:0002300)1.58322471
124Depression (HP:0000716)1.58199901
125Decreased motor nerve conduction velocity (HP:0003431)1.58144006
126Abnormality of the diencephalon (HP:0010662)1.57138803
127Scapular winging (HP:0003691)1.56650622
128Absent frontal sinuses (HP:0002688)1.55847115
129Increased circulating renin level (HP:0000848)1.55494760
130Short clavicles (HP:0000894)1.55035747
131Gastrointestinal atresia (HP:0002589)1.54833063
132Cutaneous finger syndactyly (HP:0010554)1.54574632
133Abnormality of the 4th metacarpal (HP:0010012)1.54430908
134Broad palm (HP:0001169)1.54060091
135Vertebral arch anomaly (HP:0008438)1.53924665
136Glomerulonephritis (HP:0000099)1.53875734
137Lower limb muscle weakness (HP:0007340)1.53451473
138Heterochromia iridis (HP:0001100)1.53445652
139Asymmetry of the thorax (HP:0001555)1.53041410
140Submucous cleft hard palate (HP:0000176)1.52154438
141Pulmonic stenosis (HP:0001642)1.52128821
142Tracheomalacia (HP:0002779)1.51310370
143Hammertoe (HP:0001765)1.51105567
144Clumsiness (HP:0002312)1.50970034
145Vitreoretinal degeneration (HP:0000655)1.50955143
146Limited hip movement (HP:0008800)1.50838236
147Blue irides (HP:0000635)1.50512779
148Ankyloglossia (HP:0010296)1.50126500
149Widely spaced teeth (HP:0000687)1.49982674
150Broad face (HP:0000283)1.49731552
151Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.49488647
152Aplasia/Hypoplasia of the clavicles (HP:0006710)1.49277431
153Partial duplication of thumb phalanx (HP:0009944)1.49104705
154Hemiparesis (HP:0001269)1.47362875
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.47179576
156Epiphyseal dysplasia (HP:0002656)1.46410254
157Split foot (HP:0001839)1.46365581
158Long nose (HP:0003189)1.45718877
159Overgrowth (HP:0001548)1.45537364
160Abnormality of the distal phalanx of the thumb (HP:0009617)1.45325819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.97408966
2EPHA43.47898169
3STK393.25963094
4LATS22.90264656
5TYRO32.34187476
6MARK12.25253621
7FGFR22.00447210
8BCR1.97070185
9NTRK11.94010476
10OXSR11.88768346
11WNK11.84632925
12DDR21.83451136
13EPHA31.79776679
14PKN11.76929577
15PBK1.75243410
16MAP3K21.71634491
17MET1.64866613
18TNIK1.57522165
19PAK31.56659673
20PDGFRA1.51960885
21ERBB31.49781290
22CASK1.42467161
23SGK21.42371409
24LATS11.40685400
25MAP3K141.38231720
26PRKD31.38226863
27IRAK11.37875161
28CAMK1G1.36853112
29CSNK1A1L1.35814729
30FGFR41.34595376
31BMX1.34530090
32SGK31.31742447
33PDGFRB1.27746234
34IRAK21.25170092
35SGK2231.25020108
36SGK4941.25020108
37FGR1.22878272
38UHMK11.21841687
39DAPK21.20828327
40PTK21.10905086
41MAPK131.08483553
42PAK61.08098672
43WNK41.07511641
44RIPK11.03573031
45DYRK21.01354788
46RET1.01129223
47ICK0.98486822
48ROCK20.98336451
49EPHB20.98121607
50MAPKAPK50.95755285
51HIPK20.95077840
52CHUK0.94833409
53MAPK100.93786397
54FER0.91479459
55KSR10.90858011
56PNCK0.90207441
57PTK60.86680521
58CDK150.86018166
59CSNK1G20.85498439
60DMPK0.85157254
61CAMK2G0.84632016
62GSK3A0.84450145
63CAMKK10.84166465
64LIMK10.83967247
65PRKCE0.83433537
66CDK180.82934371
67INSRR0.82830446
68MAP3K90.82783218
69CAMK1D0.81748252
70NEK60.80808974
71PLK20.79457479
72STK38L0.78989614
73MAP3K40.77592623
74NTRK30.76938963
75NTRK20.76781246
76PRKCG0.75726187
77DYRK1A0.74312891
78LMTK20.73865904
79CDK120.73220855
80CDK11A0.72761748
81NLK0.72066334
82ERBB40.70577852
83BMPR20.70530302
84CSNK1G10.67689360
85SGK10.67439852
86MAP2K20.66632266
87CAMK2A0.66589924
88FGFR10.65466592
89CLK10.65101917
90STK380.64878771
91KSR20.64734919
92IKBKB0.63686298
93JAK10.63457399
94AKT30.63267623
95CSNK1G30.62237297
96CDK50.61363086
97CAMK2B0.60535083
98ROCK10.60308412
99MAPK150.60291496
100CAMK10.58471431
101FES0.57545237
102CAMK2D0.57234375
103ALK0.56160744
104PHKG20.55961215
105PHKG10.55961215
106PRKCH0.55469397
107RPS6KA30.55310908
108MKNK10.55211432
109FGFR30.55097600
110BRD40.54652477
111ARAF0.53972660
112MINK10.53220659
113MARK20.52573574
114MST1R0.52431173
115SIK10.51847949
116CSNK1E0.50015057
117MTOR0.48816338
118NEK90.48765688
119CSK0.48576804
120INSR0.47687018
121CDK140.47120359
122PIK3CA0.46408169
123DYRK1B0.46155759
124ERBB20.46083461
125MAP2K40.46070010
126IRAK40.45992859
127TGFBR20.45722752
128BMPR1B0.44309714
129STK110.44228836
130PRKD10.43945443
131FYN0.43297816
132CDC42BPA0.42778212
133CSNK1D0.41884201
134PDPK10.41722285
135SRC0.40946285
136CAMK40.40605619
137PRKCZ0.40531764
138PRKG10.39644427

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.68570026
2Steroid biosynthesis_Homo sapiens_hsa001002.43632898
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28165910
4Synaptic vesicle cycle_Homo sapiens_hsa047212.06825697
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.06106847
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99598785
7Axon guidance_Homo sapiens_hsa043601.96318317
8Insulin secretion_Homo sapiens_hsa049111.54247649
9Dorso-ventral axis formation_Homo sapiens_hsa043201.54185982
10Renal cell carcinoma_Homo sapiens_hsa052111.46924142
11Histidine metabolism_Homo sapiens_hsa003401.46498907
12Ether lipid metabolism_Homo sapiens_hsa005651.43644606
13Thyroid hormone synthesis_Homo sapiens_hsa049181.34880558
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34473391
15Bile secretion_Homo sapiens_hsa049761.28280666
16Glutamatergic synapse_Homo sapiens_hsa047241.27938830
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26637334
18Hedgehog signaling pathway_Homo sapiens_hsa043401.26187589
19Fatty acid biosynthesis_Homo sapiens_hsa000611.25559472
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25486939
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23171748
22Basal cell carcinoma_Homo sapiens_hsa052171.21811060
23Cholinergic synapse_Homo sapiens_hsa047251.20650445
24Hippo signaling pathway_Homo sapiens_hsa043901.20138001
25Nitrogen metabolism_Homo sapiens_hsa009101.19420348
26Salivary secretion_Homo sapiens_hsa049701.15018689
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14375407
28Long-term depression_Homo sapiens_hsa047301.14254270
29ErbB signaling pathway_Homo sapiens_hsa040121.12783460
30Type II diabetes mellitus_Homo sapiens_hsa049301.11024717
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10298010
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09189951
33Complement and coagulation cascades_Homo sapiens_hsa046101.09146240
34Adherens junction_Homo sapiens_hsa045201.08492169
35TNF signaling pathway_Homo sapiens_hsa046681.05573277
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05464755
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05405633
38Proteoglycans in cancer_Homo sapiens_hsa052051.04100476
39Glioma_Homo sapiens_hsa052141.03151799
40Sphingolipid signaling pathway_Homo sapiens_hsa040711.02715366
41GABAergic synapse_Homo sapiens_hsa047271.02590924
42MicroRNAs in cancer_Homo sapiens_hsa052061.01480480
43Colorectal cancer_Homo sapiens_hsa052101.00834682
44Circadian entrainment_Homo sapiens_hsa047131.00695258
45Focal adhesion_Homo sapiens_hsa045100.99552137
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99471766
47Chemokine signaling pathway_Homo sapiens_hsa040620.99104921
48Prostate cancer_Homo sapiens_hsa052150.99071690
49Tight junction_Homo sapiens_hsa045300.98948611
50Prolactin signaling pathway_Homo sapiens_hsa049170.98502968
51Vitamin B6 metabolism_Homo sapiens_hsa007500.98073276
52Endometrial cancer_Homo sapiens_hsa052130.96821241
53Ras signaling pathway_Homo sapiens_hsa040140.95050949
54Serotonergic synapse_Homo sapiens_hsa047260.94633926
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.93690237
56Chronic myeloid leukemia_Homo sapiens_hsa052200.93618548
57Estrogen signaling pathway_Homo sapiens_hsa049150.92732629
58Pancreatic cancer_Homo sapiens_hsa052120.92120894
59TGF-beta signaling pathway_Homo sapiens_hsa043500.91486957
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91318853
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91290526
62ECM-receptor interaction_Homo sapiens_hsa045120.89088131
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89034925
64Rheumatoid arthritis_Homo sapiens_hsa053230.88460985
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88394422
66Calcium signaling pathway_Homo sapiens_hsa040200.88041722
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86918095
68Cocaine addiction_Homo sapiens_hsa050300.86618208
69Melanoma_Homo sapiens_hsa052180.86536116
70Dopaminergic synapse_Homo sapiens_hsa047280.86519006
71Melanogenesis_Homo sapiens_hsa049160.86462057
72Prion diseases_Homo sapiens_hsa050200.86168221
73Sulfur metabolism_Homo sapiens_hsa009200.85883518
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85830023
75Dilated cardiomyopathy_Homo sapiens_hsa054140.85588151
76MAPK signaling pathway_Homo sapiens_hsa040100.85574616
77Taste transduction_Homo sapiens_hsa047420.85084071
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84958024
79Wnt signaling pathway_Homo sapiens_hsa043100.84946155
80Viral myocarditis_Homo sapiens_hsa054160.83956327
81Osteoclast differentiation_Homo sapiens_hsa043800.83920325
82Gastric acid secretion_Homo sapiens_hsa049710.83897792
83Toxoplasmosis_Homo sapiens_hsa051450.83428018
84Choline metabolism in cancer_Homo sapiens_hsa052310.82679691
85Inositol phosphate metabolism_Homo sapiens_hsa005620.82349401
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82348549
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82344232
88Amoebiasis_Homo sapiens_hsa051460.80921973
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79699760
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.78487004
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78148507
92Graft-versus-host disease_Homo sapiens_hsa053320.77879860
93Pancreatic secretion_Homo sapiens_hsa049720.77492545
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77357374
95Morphine addiction_Homo sapiens_hsa050320.77086529
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76932209
97Renin secretion_Homo sapiens_hsa049240.76535974
98Arginine and proline metabolism_Homo sapiens_hsa003300.76412762
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76346186
100Endocytosis_Homo sapiens_hsa041440.75697176
101Salmonella infection_Homo sapiens_hsa051320.75176949
102Circadian rhythm_Homo sapiens_hsa047100.74727329
103Pertussis_Homo sapiens_hsa051330.74065274
104Gap junction_Homo sapiens_hsa045400.73380936
105Ovarian steroidogenesis_Homo sapiens_hsa049130.73045027
106Small cell lung cancer_Homo sapiens_hsa052220.72970326
107Pathways in cancer_Homo sapiens_hsa052000.72563740
108Vibrio cholerae infection_Homo sapiens_hsa051100.72074854
109cAMP signaling pathway_Homo sapiens_hsa040240.71741522
110Rap1 signaling pathway_Homo sapiens_hsa040150.71403116
111PPAR signaling pathway_Homo sapiens_hsa033200.71066083
112Type I diabetes mellitus_Homo sapiens_hsa049400.70952295
113Allograft rejection_Homo sapiens_hsa053300.70935323
114Leishmaniasis_Homo sapiens_hsa051400.69295535
115GnRH signaling pathway_Homo sapiens_hsa049120.68718351
116Notch signaling pathway_Homo sapiens_hsa043300.68077580
117African trypanosomiasis_Homo sapiens_hsa051430.68033158
118Long-term potentiation_Homo sapiens_hsa047200.67687734
119Autoimmune thyroid disease_Homo sapiens_hsa053200.67266292
120Amphetamine addiction_Homo sapiens_hsa050310.64193399
121Mineral absorption_Homo sapiens_hsa049780.64107449
122VEGF signaling pathway_Homo sapiens_hsa043700.63024902
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62644196
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62054806
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61505780
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.61352042
127Phagosome_Homo sapiens_hsa041450.60799587
128Oxytocin signaling pathway_Homo sapiens_hsa049210.60473102
129Hepatitis C_Homo sapiens_hsa051600.60360377
130Protein digestion and absorption_Homo sapiens_hsa049740.59470124
131Oocyte meiosis_Homo sapiens_hsa041140.58407455
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.58258549
133beta-Alanine metabolism_Homo sapiens_hsa004100.57914579
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57665977
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.56415945
136Glucagon signaling pathway_Homo sapiens_hsa049220.55154575
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53685336
138ABC transporters_Homo sapiens_hsa020100.53365085
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52422514
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51262322

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