FMNL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)4.11841693
2germinal center formation (GO:0002467)3.98120406
3NIK/NF-kappaB signaling (GO:0038061)3.90547740
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.79274740
5negative regulation of cell killing (GO:0031342)3.79274740
6vascular endothelial growth factor signaling pathway (GO:0038084)3.70130579
7regulation of dendritic cell antigen processing and presentation (GO:0002604)3.66683886
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.64541180
9regulation of gamma-delta T cell activation (GO:0046643)3.46795822
10response to peptidoglycan (GO:0032494)3.46294683
11T-helper 1 type immune response (GO:0042088)3.41553759
12regulation of T-helper 1 cell differentiation (GO:0045625)3.41497785
13myeloid dendritic cell differentiation (GO:0043011)3.40781471
14interferon-gamma-mediated signaling pathway (GO:0060333)3.37251876
15response to type I interferon (GO:0034340)3.30257845
16negative regulation of granulocyte differentiation (GO:0030853)3.28265618
17type I interferon signaling pathway (GO:0060337)3.27736723
18cellular response to type I interferon (GO:0071357)3.27736723
19regulation of antigen processing and presentation (GO:0002577)3.27621859
20positive regulation of antigen processing and presentation (GO:0002579)3.23406051
21lipopolysaccharide-mediated signaling pathway (GO:0031663)3.22071078
22germ cell migration (GO:0008354)3.15033081
23morphogenesis of an endothelium (GO:0003159)3.14839882
24endothelial tube morphogenesis (GO:0061154)3.14839882
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10845121
26myeloid dendritic cell activation (GO:0001773)3.09781628
27regulation of vitamin D biosynthetic process (GO:0060556)3.08816554
28regulation of interleukin-2 biosynthetic process (GO:0045076)3.06743290
29negative regulation of erythrocyte differentiation (GO:0045647)3.05730311
30regulation of interferon-beta biosynthetic process (GO:0045357)3.02410112
31T cell migration (GO:0072678)3.01930752
32substrate-dependent cell migration (GO:0006929)3.00984736
33cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.00924111
34CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.96666455
35regulation of mononuclear cell migration (GO:0071675)2.94174667
36negative thymic T cell selection (GO:0045060)2.92873416
37positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.91775162
38protein localization to endosome (GO:0036010)2.90704187
39defense response to protozoan (GO:0042832)2.90578300
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90445971
41positive regulation by organism of defense response of other organism involved in symbiotic interact2.90445971
42modulation by symbiont of host immune response (GO:0052553)2.90445971
43positive regulation by symbiont of host defense response (GO:0052509)2.90445971
44modulation by symbiont of host defense response (GO:0052031)2.90445971
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90445971
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.88704215
47response to laminar fluid shear stress (GO:0034616)2.88135368
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85185959
49regulation of T cell tolerance induction (GO:0002664)2.83373395
50response to protozoan (GO:0001562)2.82969342
51negative regulation of cytokine production involved in immune response (GO:0002719)2.82413010
52detection of other organism (GO:0098543)2.82080280
53positive regulation of type 2 immune response (GO:0002830)2.81267350
54nuclear pore complex assembly (GO:0051292)2.81162947
55detection of molecule of bacterial origin (GO:0032490)2.78382300
56regulation of interferon-alpha production (GO:0032647)2.77017564
57positive regulation of histone deacetylation (GO:0031065)2.74864622
58negative T cell selection (GO:0043383)2.73307007
59positive thymic T cell selection (GO:0045059)2.73103380
60endodermal cell differentiation (GO:0035987)2.71450593
61positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.71268592
62regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70889605
63mannose metabolic process (GO:0006013)2.70810679
64detection of bacterium (GO:0016045)2.70574313
65positive regulation of B cell differentiation (GO:0045579)2.70526869
66response to fluid shear stress (GO:0034405)2.69416841
67thymic T cell selection (GO:0045061)2.69045089
68regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.68475316
69cell adhesion mediated by integrin (GO:0033627)2.67260057
70positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67204777
71cellular response to ethanol (GO:0071361)2.66647827
72positive regulation of interferon-alpha production (GO:0032727)2.66504820
73keratan sulfate catabolic process (GO:0042340)2.66358664
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66289056
75regulation of B cell receptor signaling pathway (GO:0050855)2.66202016
76regulation of SMAD protein import into nucleus (GO:0060390)2.65160623
77dendritic cell differentiation (GO:0097028)2.65117229
78lymph vessel development (GO:0001945)2.65083657
79mitotic chromosome condensation (GO:0007076)2.64800180
80response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64082110
81response to host immune response (GO:0052572)2.64082110
82basement membrane organization (GO:0071711)2.63704618
83cortical actin cytoskeleton organization (GO:0030866)2.63640599
84B cell homeostasis (GO:0001782)2.63271356
85regulation of macrophage chemotaxis (GO:0010758)2.63232360
86detection of external biotic stimulus (GO:0098581)2.62965666
87apoptotic cell clearance (GO:0043277)2.62461804
88monocyte chemotaxis (GO:0002548)2.62062472
89cellular response to interferon-gamma (GO:0071346)2.61931770
90macrophage activation involved in immune response (GO:0002281)2.61926582
91blood vessel maturation (GO:0001955)2.60744602
92stress fiber assembly (GO:0043149)2.60731657
93regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59792888
94positive regulation of SMAD protein import into nucleus (GO:0060391)2.59780592
95adenosine receptor signaling pathway (GO:0001973)2.58459907
96myeloid cell activation involved in immune response (GO:0002275)2.55805342
97regulation of interleukin-12 production (GO:0032655)2.54824650
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53739526
99response to host (GO:0075136)2.53739526
100response to host defenses (GO:0052200)2.53739526
101endothelium development (GO:0003158)2.52782260
102pore complex assembly (GO:0046931)2.52471538
103pathway-restricted SMAD protein phosphorylation (GO:0060389)2.51829164
104T cell costimulation (GO:0031295)2.51612691
105microglial cell activation (GO:0001774)2.51404084
106regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.50728683
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.50678053
108B cell mediated immunity (GO:0019724)2.50677607
109positive regulation of B cell mediated immunity (GO:0002714)2.49808655
110positive regulation of immunoglobulin mediated immune response (GO:0002891)2.49808655
111T cell selection (GO:0045058)2.49141602
112macrophage activation (GO:0042116)2.48927437
113platelet-derived growth factor receptor signaling pathway (GO:0048008)2.48780920
114positive regulation of blood vessel endothelial cell migration (GO:0043536)2.47712894
115negative regulation of stress fiber assembly (GO:0051497)2.47260664
116negative regulation of T cell mediated immunity (GO:0002710)2.46899433
117lymphocyte costimulation (GO:0031294)2.46779897
118protein heterotrimerization (GO:0070208)2.46641426
119mature B cell differentiation involved in immune response (GO:0002313)2.46589605
120tolerance induction (GO:0002507)2.45103684
121regulation of interferon-gamma biosynthetic process (GO:0045072)2.44909562
122substrate adhesion-dependent cell spreading (GO:0034446)2.43863677
123positive regulation of gamma-delta T cell activation (GO:0046645)2.43703753
124collagen fibril organization (GO:0030199)2.42816559
125retina vasculature morphogenesis in camera-type eye (GO:0061299)2.40078357
126hyaluronan catabolic process (GO:0030214)2.39914517
127mitotic sister chromatid cohesion (GO:0007064)2.39481858
128cytoplasmic mRNA processing body assembly (GO:0033962)2.39333191
129positive regulation of chemokine secretion (GO:0090197)2.37908845
130cell migration involved in sprouting angiogenesis (GO:0002042)2.37799355
131growth hormone receptor signaling pathway (GO:0060396)2.37548463
132regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36439120
133antigen processing and presentation of endogenous antigen (GO:0019883)2.35397493
134positive regulation of epithelial to mesenchymal transition (GO:0010718)2.33596314
135RNA stabilization (GO:0043489)2.33381093
136mRNA stabilization (GO:0048255)2.33381093
137regulation of interleukin-12 biosynthetic process (GO:0045075)2.33061190
138nuclear pore organization (GO:0006999)2.32804932
139negative regulation of fatty acid transport (GO:2000192)2.30814971
140regulation of hippo signaling (GO:0035330)2.29990745
141corticosteroid receptor signaling pathway (GO:0031958)2.29727430
142patterning of blood vessels (GO:0001569)2.29268347
143antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27911843
144antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27911843
145regulation of integrin activation (GO:0033623)2.27824726
146regulation of gamma-delta T cell differentiation (GO:0045586)2.27381112
147positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25474402
148cellular extravasation (GO:0045123)2.24523929
149epithelial cell-cell adhesion (GO:0090136)2.24380475
150glucocorticoid receptor signaling pathway (GO:0042921)2.24290976
151skin morphogenesis (GO:0043589)2.21838736
152histone H2A monoubiquitination (GO:0035518)2.19681076
153fibroblast migration (GO:0010761)2.18655277
154coronary vasculature morphogenesis (GO:0060977)2.18643632
155blood vessel endothelial cell migration (GO:0043534)2.18485631
156cortical cytoskeleton organization (GO:0030865)2.18149318
157adherens junction assembly (GO:0034333)2.18053901
158integrin-mediated signaling pathway (GO:0007229)2.16762268
159chondrocyte proliferation (GO:0035988)2.15148447
160hippo signaling (GO:0035329)2.14108753
161response to muramyl dipeptide (GO:0032495)2.13867494
162cell-substrate junction assembly (GO:0007044)2.12928064
163wound healing, spreading of epidermal cells (GO:0035313)2.11719119
164mRNA transcription (GO:0009299)2.11445745
165regulation of mitotic spindle organization (GO:0060236)2.09238779
166establishment of endothelial barrier (GO:0061028)2.09114398
167immunoglobulin mediated immune response (GO:0016064)2.08666713
168regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.08664940
169NLS-bearing protein import into nucleus (GO:0006607)2.08314372
170axon extension involved in axon guidance (GO:0048846)2.08233374
171neuron projection extension involved in neuron projection guidance (GO:1902284)2.08233374
172B cell receptor signaling pathway (GO:0050853)2.08201052
173regulation of tight junction assembly (GO:2000810)2.07319616
174cardiac myofibril assembly (GO:0055003)2.07314491
175plasma membrane repair (GO:0001778)2.06518685
176protein localization to kinetochore (GO:0034501)2.05581536
177vagina development (GO:0060068)2.05566015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.50160615
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.36038152
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.11310265
4E2F7_22180533_ChIP-Seq_HELA_Human3.86993614
5MYC_22102868_ChIP-Seq_BL_Human3.18980985
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86422699
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.71354689
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66469170
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.64510502
10VDR_21846776_ChIP-Seq_THP-1_Human2.52365780
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.47451186
12TCF7_22412390_ChIP-Seq_EML_Mouse2.42002250
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.21767721
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21062147
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.17473531
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13397742
17* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.12605039
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10664477
19KDM2B_26808549_Chip-Seq_DND41_Human2.08362126
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02478289
21* IRF8_27001747_Chip-Seq_BMDM_Mouse2.01319112
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.98135220
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97110275
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.96845249
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.94877989
26MAF_26560356_Chip-Seq_TH1_Human1.91651919
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91375677
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91139343
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87987000
30CLOCK_20551151_ChIP-Seq_293T_Human1.87675833
31UTX_26944678_Chip-Seq_JUKART_Human1.86934380
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86195674
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85556954
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85075398
35VDR_24787735_ChIP-Seq_THP-1_Human1.82220946
36VDR_24763502_ChIP-Seq_THP-1_Human1.77521822
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77281296
38SCL_19346495_ChIP-Seq_HPC-7_Human1.76796173
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.73573214
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69642380
41SPI1_23127762_ChIP-Seq_K562_Human1.69209172
42GATA1_22025678_ChIP-Seq_K562_Human1.63367676
43* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62594261
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62413671
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62402163
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.62001077
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61468228
48MYB_26560356_Chip-Seq_TH2_Human1.51216944
49RUNX_20019798_ChIP-Seq_JUKART_Human1.50656190
50* MYB_26560356_Chip-Seq_TH1_Human1.49088031
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48897729
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48189103
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47460752
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.45279420
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44321395
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44030324
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43617510
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40620776
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40263076
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39942642
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.39121612
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.38590335
63BRD4_25478319_ChIP-Seq_HGPS_Human1.38406167
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38024032
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34809799
66ATF3_27146783_Chip-Seq_COLON_Human1.34770159
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.34328763
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34274947
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.32186069
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30393675
71* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29226048
72SPI1_23547873_ChIP-Seq_NB4_Human1.28989966
73FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.28296381
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.26550506
75AR_21909140_ChIP-Seq_LNCAP_Human1.25401090
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25342635
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.24492531
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.24492531
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.24259708
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24219632
81NCOR1_26117541_ChIP-Seq_K562_Human1.23427173
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20724839
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19745332
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.19666351
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18521012
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18236931
87GATA3_27048872_Chip-Seq_THYMUS_Human1.15580483
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15062377
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14180877
90* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14107296
91RACK7_27058665_Chip-Seq_MCF-7_Human1.13175954
92GATA1_19941826_ChIP-Seq_K562_Human1.13070132
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12808447
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12257459
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12227103
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11748916
97CJUN_26792858_Chip-Seq_BT549_Human1.10668314
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10411266
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10044964
100TP53_22127205_ChIP-Seq_IMR90_Human1.08680612
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07438898
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07438898
103* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06394340
104MAF_26560356_Chip-Seq_TH2_Human1.06251054
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05607647
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.05358920
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05292730
108ESR2_21235772_ChIP-Seq_MCF-7_Human1.03461598
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03433031
110* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03105349
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03016100
112KDM2B_26808549_Chip-Seq_K562_Human1.02375388
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02139954
114LXR_22292898_ChIP-Seq_THP-1_Human1.01380225
115PU_27001747_Chip-Seq_BMDM_Mouse1.00878834
116* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99725491
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.97482372
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96576079
119* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96224127
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95955104
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95136037
122CIITA_25753668_ChIP-Seq_RAJI_Human0.94394245
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94304954
124E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93966770
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91322983
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90178086
127* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87666307
128CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86762839
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86642047
130* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85311423
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84312626
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82892510
133SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82335433
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80747159
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79478177
136VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78735992
137* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.77581051
138DROSHA_22980978_ChIP-Seq_HELA_Human0.77305286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.16865957
2MP0003724_increased_susceptibility_to3.16129830
3MP0003705_abnormal_hypodermis_morpholog2.84541011
4MP0003303_peritoneal_inflammation2.67595405
5MP0003279_aneurysm2.59671533
6MP0002148_abnormal_hypersensitivity_rea2.57650427
7MP0010368_abnormal_lymphatic_system2.56107811
8MP0009785_altered_susceptibility_to2.50547223
9MP0005025_abnormal_response_to2.32853704
10MP0003566_abnormal_cell_adhesion2.31414124
11MP0009278_abnormal_bone_marrow2.23066411
12MP0003300_gastrointestinal_ulcer2.18240962
13MP0010352_gastrointestinal_tract_polyps1.97689301
14MP0000767_abnormal_smooth_muscle1.92295363
15MP0003172_abnormal_lysosome_physiology1.91800723
16MP0004272_abnormal_basement_membrane1.87862037
17MP0002396_abnormal_hematopoietic_system1.85029023
18MP0003091_abnormal_cell_migration1.83570615
19MP0005023_abnormal_wound_healing1.81157354
20MP0002138_abnormal_hepatobiliary_system1.80028601
21MP0005076_abnormal_cell_differentiation1.79791817
22MP0009840_abnormal_foam_cell1.77874736
23MP0000733_abnormal_muscle_development1.77388654
24MP0004808_abnormal_hematopoietic_stem1.76244198
25MP0001879_abnormal_lymphatic_vessel1.75406781
26MP0004185_abnormal_adipocyte_glucose1.67191594
27MP0010155_abnormal_intestine_physiology1.64682299
28MP0001853_heart_inflammation1.63294106
29MP0006054_spinal_hemorrhage1.62739892
30MP0001958_emphysema1.62718130
31MP0003828_pulmonary_edema1.57259285
32MP0005257_abnormal_intraocular_pressure1.55163877
33MP0005503_abnormal_tendon_morphology1.52860295
34MP0001845_abnormal_inflammatory_respons1.52617953
35MP0009764_decreased_sensitivity_to1.51711253
36MP0003075_altered_response_to1.49443748
37MP0000604_amyloidosis1.48883200
38MP0004084_abnormal_cardiac_muscle1.48520499
39MP0005275_abnormal_skin_tensile1.46420676
40MP0001915_intracranial_hemorrhage1.45012812
41MP0005310_abnormal_salivary_gland1.44076193
42MP0005623_abnormal_meninges_morphology1.39225404
43MP0004510_myositis1.37665785
44MP0009384_cardiac_valve_regurgitation1.35378262
45MP0001835_abnormal_antigen_presentation1.34407591
46MP0008007_abnormal_cellular_replicative1.29475729
47MP0005397_hematopoietic_system_phenotyp1.27890353
48MP0001545_abnormal_hematopoietic_system1.27890353
49MP0002925_abnormal_cardiovascular_devel1.22777621
50MP0001800_abnormal_humoral_immune1.22594090
51MP0002452_abnormal_antigen_presenting1.22386802
52MP0003045_fibrosis1.22118218
53MP0003690_abnormal_glial_cell1.21346842
54MP0008469_abnormal_protein_level1.21185285
55MP0000465_gastrointestinal_hemorrhage1.19197966
56MP0002933_joint_inflammation1.17199346
57MP0005167_abnormal_blood-brain_barrier1.16323132
58MP0000750_abnormal_muscle_regeneration1.15555332
59MP0009333_abnormal_splenocyte_physiolog1.15301859
60MP0003077_abnormal_cell_cycle1.14680160
61MP0006082_CNS_inflammation1.13714837
62MP0010307_abnormal_tumor_latency1.13299503
63MP0010630_abnormal_cardiac_muscle1.12436249
64MP0003453_abnormal_keratinocyte_physiol1.12066272
65MP0000343_altered_response_to1.11300217
66MP0008004_abnormal_stomach_pH1.11258396
67MP0001614_abnormal_blood_vessel1.08949235
68MP0001851_eye_inflammation1.08251599
69MP0002405_respiratory_system_inflammati1.08074600
70MP0005451_abnormal_body_composition1.06435429
71MP0000685_abnormal_immune_system1.06433064
72MP0005166_decreased_susceptibility_to1.06257235
73MP0003984_embryonic_growth_retardation1.05484285
74MP0005464_abnormal_platelet_physiology1.05309063
75MP0002128_abnormal_blood_circulation1.04534304
76MP0001873_stomach_inflammation1.04046926
77MP0002088_abnormal_embryonic_growth/wei1.03736001
78MP0005508_abnormal_skeleton_morphology1.03504670
79MP0005387_immune_system_phenotype1.03450625
80MP0001790_abnormal_immune_system1.03450625
81MP0001533_abnormal_skeleton_physiology1.02864394
82MP0000350_abnormal_cell_proliferation1.02837904
83MP0002877_abnormal_melanocyte_morpholog1.02175471
84MP0002254_reproductive_system_inflammat1.01943751
85MP0002398_abnormal_bone_marrow1.01777764
86MP0002166_altered_tumor_susceptibility1.00534303
87MP0001849_ear_inflammation0.99482996
88MP0003448_altered_tumor_morphology0.99372872
89MP0003436_decreased_susceptibility_to0.98893465
90MP0003191_abnormal_cellular_cholesterol0.98825196
91MP0002420_abnormal_adaptive_immunity0.97948262
92MP0001819_abnormal_immune_cell0.96899506
93MP0003763_abnormal_thymus_physiology0.96733142
94MP0002419_abnormal_innate_immunity0.96681175
95MP0005058_abnormal_lysosome_morphology0.96216618
96MP0000858_altered_metastatic_potential0.95639137
97MP0005380_embryogenesis_phenotype0.95284664
98MP0001672_abnormal_embryogenesis/_devel0.95284664
99MP0002998_abnormal_bone_remodeling0.95117766
100MP0005000_abnormal_immune_tolerance0.94950874
101MP0009053_abnormal_anal_canal0.94619495
102MP0002086_abnormal_extraembryonic_tissu0.94059765
103MP0000689_abnormal_spleen_morphology0.92128017
104MP0005595_abnormal_vascular_smooth0.92107722
105MP0005390_skeleton_phenotype0.91619632
106MP0002723_abnormal_immune_serum0.91236992
107MP0000266_abnormal_heart_morphology0.89589323
108MP0005671_abnormal_response_to0.89581101
109MP0005666_abnormal_adipose_tissue0.88450581
110MP0004087_abnormal_muscle_fiber0.88041962
111MP0001730_embryonic_growth_arrest0.87865275
112MP0000249_abnormal_blood_vessel0.87369042
113MP0005164_abnormal_response_to0.86601160
114MP0003385_abnormal_body_wall0.86302357
115MP0000716_abnormal_immune_system0.85721508
116MP0003111_abnormal_nucleus_morphology0.85152540
117MP0002722_abnormal_immune_system0.84841728
118MP0004883_abnormal_blood_vessel0.83983600
119MP0002928_abnormal_bile_duct0.82183643
120MP0003795_abnormal_bone_structure0.81737499
121MP0000703_abnormal_thymus_morphology0.81631912
122MP0001697_abnormal_embryo_size0.80084574
123MP0001663_abnormal_digestive_system0.80044469
124MP0006138_congestive_heart_failure0.79934663
125MP0005165_increased_susceptibility_to0.79898876
126MP0000490_abnormal_crypts_of0.79394240
127MP0002332_abnormal_exercise_endurance0.78352114
128MP0002429_abnormal_blood_cell0.78318398
129MP0004947_skin_inflammation0.78203294
130MP0003866_abnormal_defecation0.76425553
131MP0009763_increased_sensitivity_to0.76354439
132MP0000920_abnormal_myelination0.76027456
133MP0001542_abnormal_bone_strength0.73527572
134MP0003183_abnormal_peptide_metabolism0.73419665
135MP0008260_abnormal_autophagy0.70209678
136MP0003329_amyloid_beta_deposits0.68567376
137MP0002006_tumorigenesis0.61288515
138MP0001348_abnormal_lacrimal_gland0.60577455

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)5.01298991
2Protrusio acetabuli (HP:0003179)4.73213863
3Aortic aneurysm (HP:0004942)4.06357194
4Aortic dissection (HP:0002647)3.86646343
5Premature rupture of membranes (HP:0001788)3.74906227
6Mediastinal lymphadenopathy (HP:0100721)3.71316070
7Abnormality of macrophages (HP:0004311)3.70076993
8Gastrointestinal stroma tumor (HP:0100723)3.44413901
9Arterial tortuosity (HP:0005116)3.40901210
10Vascular tortuosity (HP:0004948)3.33533909
11Hematochezia (HP:0002573)3.26529977
12Shallow orbits (HP:0000586)3.24910820
13Ankle contracture (HP:0006466)3.18248824
14Dysostosis multiplex (HP:0000943)3.16530794
15Increased cerebral lipofuscin (HP:0011813)3.14780171
16Mitral valve prolapse (HP:0001634)3.14524736
17Recurrent viral infections (HP:0004429)3.03319004
18Recurrent fungal infections (HP:0002841)2.99552910
19Orchitis (HP:0100796)2.90333286
20Myositis (HP:0100614)2.87851585
21Vasculitis (HP:0002633)2.84072068
22Recurrent cutaneous fungal infections (HP:0011370)2.83786077
23Chronic mucocutaneous candidiasis (HP:0002728)2.83786077
24Pulmonary infiltrates (HP:0002113)2.83193295
25Optic neuritis (HP:0100653)2.79090238
26Retrobulbar optic neuritis (HP:0100654)2.79090238
27Meningitis (HP:0001287)2.75225245
28Dilatation of the ascending aorta (HP:0005111)2.70813327
29T lymphocytopenia (HP:0005403)2.68806391
30Aneurysm (HP:0002617)2.68288924
31Vacuolated lymphocytes (HP:0001922)2.65801198
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.63770061
33Camptodactyly of toe (HP:0001836)2.62681057
34Restrictive lung disease (HP:0002091)2.61546793
35Genu recurvatum (HP:0002816)2.57632848
36Hemoptysis (HP:0002105)2.56755893
37Cervical subluxation (HP:0003308)2.56408210
38Peritonitis (HP:0002586)2.55164089
39Bladder diverticulum (HP:0000015)2.54476235
40Short 4th metacarpal (HP:0010044)2.54464584
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54464584
42Recurrent gram-negative bacterial infections (HP:0005420)2.54345063
43Recurrent skin infections (HP:0001581)2.54238383
44Agammaglobulinemia (HP:0004432)2.52286525
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.52073209
46Urethral obstruction (HP:0000796)2.51496249
47Abnormality of the fingertips (HP:0001211)2.48661008
48IgA deficiency (HP:0002720)2.47720305
49Soft skin (HP:0000977)2.47424064
50Increased density of long bones (HP:0006392)2.47078412
51Loss of speech (HP:0002371)2.46798055
52Disproportionate tall stature (HP:0001519)2.46554742
53Abnormality of T cell number (HP:0011839)2.44173742
54Spondylolisthesis (HP:0003302)2.44077016
55Striae distensae (HP:0001065)2.42405055
56Lymphopenia (HP:0001888)2.42222659
57Increased IgE level (HP:0003212)2.41436960
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35869884
59Abnormality of polysaccharide metabolism (HP:0011012)2.35869884
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35869884
61Increased connective tissue (HP:0009025)2.35703981
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.35241543
63Osteolytic defects of the hand bones (HP:0009699)2.35241543
64Gingivitis (HP:0000230)2.34212380
65Ulnar bowing (HP:0003031)2.32183933
66Urinary glycosaminoglycan excretion (HP:0003541)2.30829545
67Mucopolysacchariduria (HP:0008155)2.30829545
68Neurofibrillary tangles (HP:0002185)2.27689689
69Interstitial pulmonary disease (HP:0006530)2.24934371
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.24661294
71Broad metatarsal (HP:0001783)2.23179018
72Abnormality of the vasculature of the conjunctiva (HP:0008054)2.21922344
73Panhypogammaglobulinemia (HP:0003139)2.19754257
74Wrist flexion contracture (HP:0001239)2.19442894
75Bicuspid aortic valve (HP:0001647)2.16491743
76Chronic obstructive pulmonary disease (HP:0006510)2.15207467
77Obstructive lung disease (HP:0006536)2.15207467
78Flexion contracture of toe (HP:0005830)2.13523107
79Joint contractures involving the joints of the feet (HP:0100492)2.13523107
80Abnormality of the peritoneum (HP:0002585)2.12538313
81Spontaneous hematomas (HP:0007420)2.11481928
82Blue sclerae (HP:0000592)2.11432365
83Pustule (HP:0200039)2.10035789
84Porencephaly (HP:0002132)2.09775098
85Stomatitis (HP:0010280)2.08667794
86Cellulitis (HP:0100658)2.07272488
87Complement deficiency (HP:0004431)2.07005740
88Esophageal varix (HP:0002040)2.05988112
89Recurrent bronchitis (HP:0002837)2.05494572
90Subacute progressive viral hepatitis (HP:0006572)2.04318072
91Axonal loss (HP:0003447)2.04025308
92Upper motor neuron abnormality (HP:0002127)2.02616039
93Elevated erythrocyte sedimentation rate (HP:0003565)2.01833541
94Acrocyanosis (HP:0001063)2.01075956
95Atrophic scars (HP:0001075)2.00860876
96Dislocated radial head (HP:0003083)1.99744932
97Abnormality of the 4th metacarpal (HP:0010012)1.98288783
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97697385
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96339007
100Emphysema (HP:0002097)1.94781779
101Chest pain (HP:0100749)1.93532065
102Hyperacusis (HP:0010780)1.92872095
103Systemic lupus erythematosus (HP:0002725)1.92281113
104Recurrent abscess formation (HP:0002722)1.92254719
105Encephalitis (HP:0002383)1.92058069
106Keratoconjunctivitis sicca (HP:0001097)1.90564170
107Arthralgia (HP:0002829)1.90314998
108Colitis (HP:0002583)1.89630341
109Conjunctival telangiectasia (HP:0000524)1.89601026
110Eczematoid dermatitis (HP:0000976)1.87977096
111Abnormality of the radial head (HP:0003995)1.87909868
112Gastrointestinal infarctions (HP:0005244)1.86606104
113Wormian bones (HP:0002645)1.85903991
114Increased IgM level (HP:0003496)1.85753968
115Abnormality of complement system (HP:0005339)1.85336401
116Osteomyelitis (HP:0002754)1.84990129
117Asymmetric septal hypertrophy (HP:0001670)1.83901617
118Basal ganglia calcification (HP:0002135)1.83195293
119Persistence of primary teeth (HP:0006335)1.82458224
120Recurrent lower respiratory tract infections (HP:0002783)1.82207403
121Epistaxis (HP:0000421)1.81960069
122Autoimmune hemolytic anemia (HP:0001890)1.81738994
123Polycythemia (HP:0001901)1.81322170
124Joint laxity (HP:0001388)1.81313957
125Syringomyelia (HP:0003396)1.81121866
126Spinal cord lesions (HP:0100561)1.81121866
127Bowel diverticulosis (HP:0005222)1.80569620
128Abnormality of T cells (HP:0002843)1.80479238
129Glomerulonephritis (HP:0000099)1.80412055
130Abnormality of liposaccharide metabolism (HP:0010968)1.78777036
131Abnormality of glycosphingolipid metabolism (HP:0004343)1.78777036
132Abnormality of glycolipid metabolism (HP:0010969)1.78777036
133Thoracic kyphosis (HP:0002942)1.78660120
134Long eyelashes (HP:0000527)1.78083907
135Neuronal loss in central nervous system (HP:0002529)1.77763298
136Scapular winging (HP:0003691)1.77702765
137Leukocytosis (HP:0001974)1.77003098
138Obstructive sleep apnea (HP:0002870)1.76526097
139High pitched voice (HP:0001620)1.76359197
140Joint stiffness (HP:0001387)1.76128342
141Hypergammaglobulinemia (HP:0010702)1.76101667
142Hallux valgus (HP:0001822)1.75361559
143Thin bony cortex (HP:0002753)1.75354568
144Myocardial infarction (HP:0001658)1.75246387
145Deviation of the hallux (HP:0010051)1.74914669
146Type 1 muscle fiber predominance (HP:0003803)1.74164843
147Mitral regurgitation (HP:0001653)1.72067932
148Spinal rigidity (HP:0003306)1.71913784
149Lymphangioma (HP:0100764)1.69623205
150Abnormality of the acetabulum (HP:0003170)1.67906170
151Abnormality of the nasal mucosa (HP:0000433)1.63013335
152Absent frontal sinuses (HP:0002688)1.61663314
153Asymmetry of the thorax (HP:0001555)1.59813831
154Broad thumb (HP:0011304)1.57083006
155Recurrent bacterial skin infections (HP:0005406)1.56927528
156Elbow flexion contracture (HP:0002987)1.56537708
157Biconcave vertebral bodies (HP:0004586)1.55809011
158Difficulty climbing stairs (HP:0003551)1.55234894
159Abnormality of the calcaneus (HP:0008364)1.54895881
160Inflammation of the large intestine (HP:0002037)1.52770636
161Aortic regurgitation (HP:0001659)1.51950988
162Enlarged penis (HP:0000040)1.51945569
163Muscle fiber splitting (HP:0003555)1.51894641
164Viral hepatitis (HP:0006562)1.51826114
165Autoimmune thrombocytopenia (HP:0001973)1.51768559
166Radial bowing (HP:0002986)1.51328067
167Fragile skin (HP:0001030)1.50997218
168Limited elbow extension (HP:0001377)1.50580341
169Gastrointestinal inflammation (HP:0004386)1.50379062
170Disinhibition (HP:0000734)1.50127161
171Nonimmune hydrops fetalis (HP:0001790)1.49620489
172Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.48866278
173Slender build (HP:0001533)1.48367112
174Arnold-Chiari malformation (HP:0002308)1.48186297
175Vertebral compression fractures (HP:0002953)1.47933224
176Venous abnormality (HP:0002624)1.47188785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.30084572
2TRIB33.76297819
3LATS13.29023361
4PKN23.12380000
5MAP3K142.99866882
6RIPK42.88800216
7IRAK32.86538042
8PRPF4B2.84524676
9TTN2.79422635
10EEF2K2.74185628
11STK102.47738245
12MAP4K12.43725884
13CDK122.40817746
14ERN12.17146288
15MAP3K132.05503350
16CDC42BPA1.98564801
17FES1.96256377
18PAK41.91138088
19CSF1R1.88001536
20KDR1.85740328
21TIE11.82986779
22MAP3K101.82886378
23LATS21.81971852
24PDGFRA1.76120139
25IKBKE1.69343323
26STK31.66246877
27CAMK1D1.63833672
28DMPK1.58008916
29PTK61.56052979
30LRRK21.52493007
31SYK1.46085831
32MATK1.45887031
33TXK1.45550326
34IRAK41.37328000
35FGR1.35654944
36RIPK11.34805422
37NEK21.34602946
38GRK71.29446527
39RPS6KA41.28028009
40JAK31.27058960
41TAOK21.26715018
42TYK21.23254411
43PAK21.21443911
44KIT1.20596406
45EPHB11.20072839
46MAP2K31.16856657
47CAMK1G1.16701499
48TGFBR11.16419384
49NME21.14900991
50SMG11.13429336
51TAOK11.12905772
52MAP3K111.10790756
53PDGFRB1.09031489
54ZAP701.07241998
55MOS1.06160564
56JAK11.05923278
57MAPK71.03805372
58DDR21.00207304
59STK38L0.98334914
60ICK0.97200453
61TRPM70.97047381
62HCK0.95083703
63MTOR0.93933777
64MARK20.91718906
65CSK0.88252563
66MAP3K80.86660560
67CDC70.85630175
68CDK60.80866253
69CLK10.79071301
70CDK40.78914607
71ITK0.78335828
72TBK10.77856006
73NEK90.76543387
74SIK10.76077681
75CDK90.75021960
76MAP3K10.73223678
77MELK0.72595924
78FGFR40.71706840
79PRKD20.71345728
80TEC0.70278854
81PTK20.69988432
82MAP3K60.69792281
83FGFR30.69297529
84RPS6KA20.67222518
85PTK2B0.66725520
86HIPK20.66555423
87CDK80.66261334
88TAOK30.65568324
89MARK30.63011562
90MAPK150.61809462
91CHUK0.60388823
92ILK0.59602986
93PRKD10.59247562
94PDK10.58690347
95SIK20.58067586
96BLK0.57969560
97BMX0.57534798
98RPS6KC10.56693720
99RPS6KL10.56693720
100BTK0.56572932
101RET0.56544122
102BMPR20.56307623
103MAPK40.55627047
104TTK0.54918116
105PRKCH0.54651489
106MAP3K30.54066814
107TNK20.54064362
108FLT30.53147390
109ALK0.52852845
110ABL10.51846331
111PDPK10.51797566
112CAMKK10.51543010
113MAP3K70.49945571
114EPHA30.48498838
115LCK0.46219391
116RPS6KA60.46168731
117SCYL20.46036177
118SGK30.45607381
119PIM10.45438171
120MAPKAPK30.44993891
121FYN0.44821685
122MAPK110.44459835
123JAK20.44308670
124MAPKAPK20.44113975
125CDK70.43076203
126RPS6KB20.42384435
127CAMKK20.41510916
128IRAK10.41340271
129TESK20.41000600
130NLK0.40770465
131PRKCQ0.38304158
132SIK30.37888888
133TYRO30.36703198
134IKBKB0.36358417
135STK40.36301019
136INSR0.33771693
137EGFR0.32735439
138TSSK60.31757573
139MAPK120.30695538
140IGF1R0.29429166
141LYN0.28140317
142STK380.27959551
143EPHB20.26502826
144PRKD30.26177467

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.66373250
2Graft-versus-host disease_Homo sapiens_hsa053322.49624279
3Autoimmune thyroid disease_Homo sapiens_hsa053202.40481118
4Asthma_Homo sapiens_hsa053102.14739003
5B cell receptor signaling pathway_Homo sapiens_hsa046622.08943224
6Chronic myeloid leukemia_Homo sapiens_hsa052201.96265540
7Osteoclast differentiation_Homo sapiens_hsa043801.89921841
8Rheumatoid arthritis_Homo sapiens_hsa053231.85922168
9Focal adhesion_Homo sapiens_hsa045101.83314970
10Type I diabetes mellitus_Homo sapiens_hsa049401.80558943
11Pancreatic cancer_Homo sapiens_hsa052121.80450257
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.77711993
13Adherens junction_Homo sapiens_hsa045201.75768244
14Small cell lung cancer_Homo sapiens_hsa052221.74106838
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.72757017
16ECM-receptor interaction_Homo sapiens_hsa045121.72055428
17Leishmaniasis_Homo sapiens_hsa051401.71588635
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67682546
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.65013407
20Toxoplasmosis_Homo sapiens_hsa051451.59709747
21MicroRNAs in cancer_Homo sapiens_hsa052061.55596061
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54195806
23Viral myocarditis_Homo sapiens_hsa054161.49649480
24Other glycan degradation_Homo sapiens_hsa005111.47833305
25Notch signaling pathway_Homo sapiens_hsa043301.47665754
26Proteoglycans in cancer_Homo sapiens_hsa052051.43960708
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39383570
28Platelet activation_Homo sapiens_hsa046111.39246512
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38448086
30Antigen processing and presentation_Homo sapiens_hsa046121.37584650
31Colorectal cancer_Homo sapiens_hsa052101.33555985
32Renal cell carcinoma_Homo sapiens_hsa052111.29011327
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27336479
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.26999803
35HTLV-I infection_Homo sapiens_hsa051661.25475360
36Shigellosis_Homo sapiens_hsa051311.24807470
37Malaria_Homo sapiens_hsa051441.24628531
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22723748
39Hepatitis B_Homo sapiens_hsa051611.20910012
40TGF-beta signaling pathway_Homo sapiens_hsa043501.18901350
41VEGF signaling pathway_Homo sapiens_hsa043701.18551170
42Hematopoietic cell lineage_Homo sapiens_hsa046401.17562648
43Amoebiasis_Homo sapiens_hsa051461.17510836
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17432217
45Cell cycle_Homo sapiens_hsa041101.14893196
46Staphylococcus aureus infection_Homo sapiens_hsa051501.14455282
47TNF signaling pathway_Homo sapiens_hsa046681.11767082
48Prion diseases_Homo sapiens_hsa050201.11503528
49Acute myeloid leukemia_Homo sapiens_hsa052211.10653596
50Measles_Homo sapiens_hsa051621.10520831
51Phagosome_Homo sapiens_hsa041451.10398315
52Apoptosis_Homo sapiens_hsa042101.10033233
53Non-small cell lung cancer_Homo sapiens_hsa052231.09590653
54Primary immunodeficiency_Homo sapiens_hsa053401.07893928
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06027661
56p53 signaling pathway_Homo sapiens_hsa041151.04129871
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.03132524
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03027860
59mTOR signaling pathway_Homo sapiens_hsa041501.02282857
60Dilated cardiomyopathy_Homo sapiens_hsa054141.01967257
61Dorso-ventral axis formation_Homo sapiens_hsa043201.01807007
62Prostate cancer_Homo sapiens_hsa052151.00789681
63African trypanosomiasis_Homo sapiens_hsa051431.00317558
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00313073
65Hepatitis C_Homo sapiens_hsa051600.99873190
66T cell receptor signaling pathway_Homo sapiens_hsa046600.98373910
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97789259
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97254830
69Herpes simplex infection_Homo sapiens_hsa051680.97034646
70Pathways in cancer_Homo sapiens_hsa052000.95691914
71Viral carcinogenesis_Homo sapiens_hsa052030.95001312
72Rap1 signaling pathway_Homo sapiens_hsa040150.94748631
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.93861482
74Tuberculosis_Homo sapiens_hsa051520.93859006
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91757082
76Chemokine signaling pathway_Homo sapiens_hsa040620.90991666
77Lysine degradation_Homo sapiens_hsa003100.90042976
78Glioma_Homo sapiens_hsa052140.89731637
79Influenza A_Homo sapiens_hsa051640.88818051
80Endometrial cancer_Homo sapiens_hsa052130.88557243
81Prolactin signaling pathway_Homo sapiens_hsa049170.88162568
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87128866
83Pertussis_Homo sapiens_hsa051330.85953051
84HIF-1 signaling pathway_Homo sapiens_hsa040660.85889383
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85681622
86Salmonella infection_Homo sapiens_hsa051320.84318279
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83727560
88FoxO signaling pathway_Homo sapiens_hsa040680.83051538
89Lysosome_Homo sapiens_hsa041420.82316643
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82132488
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80013797
92Hippo signaling pathway_Homo sapiens_hsa043900.79689826
93Endocytosis_Homo sapiens_hsa041440.79277721
94Bladder cancer_Homo sapiens_hsa052190.78867888
95Estrogen signaling pathway_Homo sapiens_hsa049150.75355260
96Legionellosis_Homo sapiens_hsa051340.74878676
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74805331
98Epstein-Barr virus infection_Homo sapiens_hsa051690.73903208
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73282629
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72251186
101Insulin resistance_Homo sapiens_hsa049310.70961689
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70418436
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68433621
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.67700547
105MAPK signaling pathway_Homo sapiens_hsa040100.66533385
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65587734
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64582545
108Melanoma_Homo sapiens_hsa052180.62609683
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.61247061
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60969779
111GnRH signaling pathway_Homo sapiens_hsa049120.60895959
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60194140
113Choline metabolism in cancer_Homo sapiens_hsa052310.59948391
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59247036
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57921541
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.57372496
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.57114639
118RNA transport_Homo sapiens_hsa030130.56042131
119Type II diabetes mellitus_Homo sapiens_hsa049300.46539424
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46283219
121Systemic lupus erythematosus_Homo sapiens_hsa053220.45778153
122Complement and coagulation cascades_Homo sapiens_hsa046100.41716606
123Ras signaling pathway_Homo sapiens_hsa040140.41268949

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