FMO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.11984854
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.11984854
3angiotensin maturation (GO:0002003)7.09415617
4L-phenylalanine metabolic process (GO:0006558)6.66515771
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.66515771
6epoxygenase P450 pathway (GO:0019373)6.34781928
7aromatic amino acid family catabolic process (GO:0009074)6.03710533
8regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.54144483
9glyoxylate metabolic process (GO:0046487)5.36159855
10tryptophan catabolic process (GO:0006569)5.05301373
11indole-containing compound catabolic process (GO:0042436)5.05301373
12indolalkylamine catabolic process (GO:0046218)5.05301373
13bile acid biosynthetic process (GO:0006699)5.03691609
14lipoprotein transport (GO:0042953)4.98640561
15cysteine metabolic process (GO:0006534)4.87454223
16intestinal absorption (GO:0050892)4.85464481
17tryptophan metabolic process (GO:0006568)4.82855698
18hormone catabolic process (GO:0042447)4.81836516
19alpha-linolenic acid metabolic process (GO:0036109)4.80144847
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.72849151
21plasma lipoprotein particle assembly (GO:0034377)4.61862496
22kynurenine metabolic process (GO:0070189)4.60201156
23sulfur amino acid catabolic process (GO:0000098)4.58240856
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46574436
25aromatic amino acid family metabolic process (GO:0009072)4.37888025
26tyrosine metabolic process (GO:0006570)4.35461333
27lysine catabolic process (GO:0006554)4.35117650
28lysine metabolic process (GO:0006553)4.35117650
29sulfate transmembrane transport (GO:1902358)4.35012684
30fat-soluble vitamin biosynthetic process (GO:0042362)4.31956965
31short-chain fatty acid metabolic process (GO:0046459)4.30598379
32drug transmembrane transport (GO:0006855)4.30479971
33drug catabolic process (GO:0042737)4.26417428
34very-low-density lipoprotein particle assembly (GO:0034379)4.26301601
35bile acid metabolic process (GO:0008206)4.23379094
36ethanol oxidation (GO:0006069)4.23135557
37regulation of guanylate cyclase activity (GO:0031282)4.21718509
38high-density lipoprotein particle remodeling (GO:0034375)4.21117432
39serine family amino acid catabolic process (GO:0009071)4.16017018
40homocysteine metabolic process (GO:0050667)4.13505360
41alpha-amino acid catabolic process (GO:1901606)4.10511841
42cellular ketone body metabolic process (GO:0046950)4.06693676
43negative regulation of fibrinolysis (GO:0051918)4.06347531
44peptidyl-glutamic acid carboxylation (GO:0017187)4.06207721
45protein carboxylation (GO:0018214)4.06207721
46amino-acid betaine metabolic process (GO:0006577)4.03948821
47sphingoid metabolic process (GO:0046519)4.02976428
48complement activation, alternative pathway (GO:0006957)4.01799781
49regulation of fibrinolysis (GO:0051917)4.01532508
50regulation of triglyceride catabolic process (GO:0010896)3.99151754
51protein-lipid complex assembly (GO:0065005)3.98391075
52regulation of protein glycosylation (GO:0060049)3.96595728
53urea metabolic process (GO:0019627)3.96349404
54urea cycle (GO:0000050)3.96349404
55urate metabolic process (GO:0046415)3.95626712
56regulation of protein activation cascade (GO:2000257)3.89832257
57vitamin transmembrane transport (GO:0035461)3.89198840
58cellular amino acid catabolic process (GO:0009063)3.87427362
59sphingosine metabolic process (GO:0006670)3.87273296
60acetyl-CoA metabolic process (GO:0006084)3.83479814
61regulation of cholesterol esterification (GO:0010872)3.82965100
62fatty acid elongation (GO:0030497)3.82367953
63diol metabolic process (GO:0034311)3.78302053
64nitrogen cycle metabolic process (GO:0071941)3.76445640
65plasma lipoprotein particle clearance (GO:0034381)3.76395749
66triglyceride homeostasis (GO:0070328)3.76226768
67acylglycerol homeostasis (GO:0055090)3.76226768
68positive regulation of triglyceride lipase activity (GO:0061365)3.74953205
69positive regulation of lipoprotein lipase activity (GO:0051006)3.74953205
70NADH metabolic process (GO:0006734)3.74631812
71very long-chain fatty acid metabolic process (GO:0000038)3.74603803
72coenzyme catabolic process (GO:0009109)3.74482385
73cellular glucuronidation (GO:0052695)3.74201749
74diacylglycerol metabolic process (GO:0046339)3.72919888
75fatty acid beta-oxidation (GO:0006635)3.72072517
76amine catabolic process (GO:0009310)3.71873019
77cellular biogenic amine catabolic process (GO:0042402)3.71873019
78positive regulation of lipid catabolic process (GO:0050996)3.71283938
79fatty acid oxidation (GO:0019395)3.70704497
80reverse cholesterol transport (GO:0043691)3.70627942
81exogenous drug catabolic process (GO:0042738)3.68845934
82indolalkylamine metabolic process (GO:0006586)3.68813035
83endocrine process (GO:0050886)3.67129316
84regulation of systemic arterial blood pressure by hormone (GO:0001990)3.67129316
85regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.67129316
86aldehyde catabolic process (GO:0046185)3.66224058
87regulation of complement activation (GO:0030449)3.65985908
88glutamate metabolic process (GO:0006536)3.65984074
89protein-lipid complex remodeling (GO:0034368)3.64925546
90macromolecular complex remodeling (GO:0034367)3.64925546
91plasma lipoprotein particle remodeling (GO:0034369)3.64925546
92L-ascorbic acid metabolic process (GO:0019852)3.64848987
93lipid oxidation (GO:0034440)3.64833835
94aspartate family amino acid catabolic process (GO:0009068)3.62802479
95sterol homeostasis (GO:0055092)3.61253234
96uronic acid metabolic process (GO:0006063)3.59172110
97glucuronate metabolic process (GO:0019585)3.59172110
98carboxylic acid catabolic process (GO:0046395)3.59052004
99organic acid catabolic process (GO:0016054)3.59052004
100benzene-containing compound metabolic process (GO:0042537)3.56527507
101ketone body metabolic process (GO:1902224)3.55116892
102monocarboxylic acid catabolic process (GO:0072329)3.54315791
103serine family amino acid metabolic process (GO:0009069)3.52689360
104cellular modified amino acid catabolic process (GO:0042219)3.52325204
105protein-chromophore linkage (GO:0018298)3.52143095
106fatty acid catabolic process (GO:0009062)3.51505152
107fructose metabolic process (GO:0006000)3.51207162
108trivalent inorganic anion homeostasis (GO:0072506)3.49777751
109phosphate ion homeostasis (GO:0055062)3.49777751
110lipoprotein metabolic process (GO:0042157)3.46859680
111sulfate transport (GO:0008272)3.46841498
112iron coordination entity transport (GO:1901678)3.46736694
113branched-chain amino acid catabolic process (GO:0009083)3.46552938
114omega-hydroxylase P450 pathway (GO:0097267)3.45848644
115regulation of systemic arterial blood pressure (GO:0003073)3.45667237
116valine metabolic process (GO:0006573)3.44972078
117* drug metabolic process (GO:0017144)3.44766183
118regulation of bile acid biosynthetic process (GO:0070857)3.43823982
119drug transport (GO:0015893)3.42532228
120excretion (GO:0007588)3.41868916
121transepithelial transport (GO:0070633)3.40235175
122phospholipid efflux (GO:0033700)3.39473612
123regulation of lipoprotein metabolic process (GO:0050746)3.39278091
124heme transport (GO:0015886)3.38050474
125vitamin transport (GO:0051180)3.36591542
126glycerol metabolic process (GO:0006071)3.35767622
127cholesterol efflux (GO:0033344)3.35371253
128negative regulation of cholesterol transport (GO:0032375)3.34298185
129negative regulation of sterol transport (GO:0032372)3.34298185
130branched-chain amino acid metabolic process (GO:0009081)3.32463199
131flavonoid metabolic process (GO:0009812)3.31908965
132positive regulation of guanylate cyclase activity (GO:0031284)3.31414237
133serine family amino acid biosynthetic process (GO:0009070)3.30075523
134regulation of cholesterol metabolic process (GO:0090181)3.29304632
135ethanol metabolic process (GO:0006067)3.28452300
136bile acid and bile salt transport (GO:0015721)3.28378553
137response to mercury ion (GO:0046689)3.26791254
138adhesion of symbiont to host cell (GO:0044650)3.24723517
139virion attachment to host cell (GO:0019062)3.24723517
140negative regulation of lipase activity (GO:0060192)3.24546390
141alkaloid metabolic process (GO:0009820)3.22732820
142plasma lipoprotein particle organization (GO:0071827)3.22417583
143arginine metabolic process (GO:0006525)3.20760587
144cholesterol homeostasis (GO:0042632)3.20668265
145cofactor catabolic process (GO:0051187)3.20446742
146acyl-CoA metabolic process (GO:0006637)3.20430839
147drinking behavior (GO:0042756)3.13656822
148positive regulation of triglyceride metabolic process (GO:0090208)3.13270460
149digestion (GO:0007586)3.12470784
150vitamin biosynthetic process (GO:0009110)3.12392408
151cellular response to nitric oxide (GO:0071732)3.10500070
152alditol metabolic process (GO:0019400)3.06752178
153vitamin D metabolic process (GO:0042359)3.06535777
154regulation of digestive system process (GO:0044058)3.05759353
155sulfur compound transport (GO:0072348)3.01629737
156fat-soluble vitamin metabolic process (GO:0006775)3.01153739
157sulfation (GO:0051923)2.99058269
158protein-lipid complex subunit organization (GO:0071825)2.96248014
159phospholipid homeostasis (GO:0055091)2.95031875
160adhesion of symbiont to host (GO:0044406)2.84009538
161glutamine family amino acid biosynthetic process (GO:0009084)2.79525005
162regulation of cGMP biosynthetic process (GO:0030826)2.78221956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.58279857
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.18901925
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.17790852
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.08426744
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.05243199
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.40439217
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.00202729
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.51302290
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.04130202
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.80282266
11PCGF2_27294783_Chip-Seq_NPCs_Mouse1.83935542
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79170015
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73757187
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73637195
15SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67428870
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64981136
17IGF1R_20145208_ChIP-Seq_DFB_Human1.63947275
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59024374
19* NFE2_27457419_Chip-Seq_LIVER_Mouse1.58543375
20CDX2_22108803_ChIP-Seq_LS180_Human1.57284930
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57080624
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.54572313
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49547671
24ZNF274_21170338_ChIP-Seq_K562_Hela1.49017103
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.46107670
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45642801
27* NANOG_19829295_ChIP-Seq_ESCs_Human1.42588312
28* SOX2_19829295_ChIP-Seq_ESCs_Human1.42588312
29TCF4_22108803_ChIP-Seq_LS180_Human1.42414880
30EZH2_22144423_ChIP-Seq_EOC_Human1.41686952
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38661888
32TAF15_26573619_Chip-Seq_HEK293_Human1.38423574
33HTT_18923047_ChIP-ChIP_STHdh_Human1.36682456
34* CLOCK_20551151_ChIP-Seq_293T_Human1.36489442
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34863273
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29644886
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28582335
38FUS_26573619_Chip-Seq_HEK293_Human1.27431061
39RXR_22108803_ChIP-Seq_LS180_Human1.27196379
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25856877
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25856877
42* CRX_20693478_ChIP-Seq_RETINA_Mouse1.24497125
43GBX2_23144817_ChIP-Seq_PC3_Human1.24191587
44GATA1_22025678_ChIP-Seq_K562_Human1.23877303
45AR_25329375_ChIP-Seq_VCAP_Human1.22141301
46FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21742245
47* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21305013
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20611669
49NCOR_22424771_ChIP-Seq_293T_Human1.18804201
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.18152368
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17187657
52* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16459879
53CJUN_26792858_Chip-Seq_BT549_Human1.15716111
54STAT3_23295773_ChIP-Seq_U87_Human1.15584623
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.14142553
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14128970
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.13865838
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13430668
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.13149164
60* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12619697
61SMAD4_21799915_ChIP-Seq_A2780_Human1.10490436
62* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10391190
63* FOXA1_25329375_ChIP-Seq_VCAP_Human1.10391190
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.10295641
65CBP_20019798_ChIP-Seq_JUKART_Human1.08012768
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08012768
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07867427
68* P53_22387025_ChIP-Seq_ESCs_Mouse1.07119476
69* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05311040
70TCF4_23295773_ChIP-Seq_U87_Human1.04653180
71HNF4A_19822575_ChIP-Seq_HepG2_Human1.04502587
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04448869
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04377342
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03815961
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03461691
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.03283374
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02977091
78AR_20517297_ChIP-Seq_VCAP_Human1.02965431
79* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02648377
80* STAT3_18555785_Chip-Seq_ESCs_Mouse1.02567265
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.02033490
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01150326
83TP63_23658742_ChIP-Seq_EP156T_Human1.01150030
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01097637
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00242720
86* PHF8_20622853_ChIP-Seq_HELA_Human0.99065156
87HOXB7_26014856_ChIP-Seq_BT474_Human0.98225374
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97508912
89* E2F1_18555785_Chip-Seq_ESCs_Mouse0.96539432
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92195711
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.89709128
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89679581
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88158355
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87364962
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86872677
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.86827449
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85315907
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.82654359
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82068632
100GATA4_25053715_ChIP-Seq_YYC3_Human0.81202012
101VDR_22108803_ChIP-Seq_LS180_Human0.80611343
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79864339
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.79653658
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79592149
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79319932
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79305080
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78322257
108* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77815369
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77139047
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76862373
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.75680260
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74853018
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74677797
114SOX2_20726797_ChIP-Seq_SW620_Human0.74156314
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73258947
116FOXA1_25552417_ChIP-Seq_VCAP_Human0.73238428
117EED_16625203_ChIP-ChIP_MESCs_Mouse0.72593324
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.72269086
119ZFP57_27257070_Chip-Seq_ESCs_Mouse0.72259748
120BCAT_22108803_ChIP-Seq_LS180_Human0.71224813
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.70896536
122MTF2_20144788_ChIP-Seq_MESCs_Mouse0.70705269
123CBP_21632823_ChIP-Seq_H3396_Human0.69866802
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67634659
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.67633133
126IRF1_19129219_ChIP-ChIP_H3396_Human0.67525412
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.67018271
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.66994004
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.65277205
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.64948913
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.64727283
132P300_19829295_ChIP-Seq_ESCs_Human0.64482453
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64432773
134ER_23166858_ChIP-Seq_MCF-7_Human0.64397580
135PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63965679
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.63779892
137AR_21572438_ChIP-Seq_LNCaP_Human0.62823766
138AHR_22903824_ChIP-Seq_MCF-7_Human0.62030490
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.61992420
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.61846326
141CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.61753692
142* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.60950663
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.60812414
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60720953
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60688477
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.60323154
147GATA1_19941826_ChIP-Seq_K562_Human0.60024653
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.59283656
149SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.59230782
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.59198743
151WT1_19549856_ChIP-ChIP_CCG9911_Human0.59030424
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.58898997
153TP53_18474530_ChIP-ChIP_U2OS_Human0.58846538
154RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58625781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.26825330
2MP0005360_urolithiasis7.04843108
3MP0005085_abnormal_gallbladder_physiolo5.20536232
4MP0005365_abnormal_bile_salt5.09763001
5MP0008875_abnormal_xenobiotic_pharmacok5.06528297
6MP0003806_abnormal_nucleotide_metabolis3.62104660
7MP0003252_abnormal_bile_duct3.24181027
8MP0005332_abnormal_amino_acid3.19707791
9MP0003195_calcinosis3.12746173
10MP0003136_yellow_coat_color3.05816606
11MP0010329_abnormal_lipoprotein_level2.98844474
12MP0004019_abnormal_vitamin_homeostasis2.74096682
13MP0005083_abnormal_biliary_tract2.53168035
14MP0002138_abnormal_hepatobiliary_system2.51843479
15MP0003183_abnormal_peptide_metabolism2.42252503
16MP0004264_abnormal_extraembryonic_tissu2.38897991
17MP0009840_abnormal_foam_cell2.34862077
18MP0002118_abnormal_lipid_homeostasis2.09232301
19MP0001666_abnormal_nutrient_absorption2.04763154
20MP0003191_abnormal_cellular_cholesterol2.02619719
21MP0004043_abnormal_pH_regulation1.96266435
22MP0003890_abnormal_embryonic-extraembry1.95062364
23MP0003879_abnormal_hair_cell1.83377043
24MP0009643_abnormal_urine_homeostasis1.80824839
25MP0002653_abnormal_ependyma_morphology1.79172035
26MP0003045_fibrosis1.77371944
27MP0000609_abnormal_liver_physiology1.74850584
28MP0005171_absent_coat_pigmentation1.66609966
29MP0005451_abnormal_body_composition1.66251414
30MP0003690_abnormal_glial_cell1.65546794
31MP0009379_abnormal_foot_pigmentation1.64093459
32MP0005584_abnormal_enzyme/coenzyme_acti1.63570188
33MP0005319_abnormal_enzyme/_coenzyme1.54406240
34MP0003186_abnormal_redox_activity1.52609903
35MP0010368_abnormal_lymphatic_system1.43749089
36MP0001764_abnormal_homeostasis1.42025564
37MP0002938_white_spotting1.40646544
38MP0005408_hypopigmentation1.36839166
39MP0003868_abnormal_feces_composition1.34979304
40MP0005670_abnormal_white_adipose1.34974311
41MP0000920_abnormal_myelination1.32300370
42MP0005636_abnormal_mineral_homeostasis1.32173907
43MP0003724_increased_susceptibility_to1.28558401
44MP0005503_abnormal_tendon_morphology1.28033646
45MP0008872_abnormal_physiological_respon1.26016324
46MP0001661_extended_life_span1.24207033
47MP0004147_increased_porphyrin_level1.16963073
48MP0001485_abnormal_pinna_reflex1.16627767
49MP0009697_abnormal_copulation1.15688284
50MP0000604_amyloidosis1.12594699
51MP0003329_amyloid_beta_deposits1.12182553
52MP0001501_abnormal_sleep_pattern1.12180976
53MP0003011_delayed_dark_adaptation1.11777999
54MP0003646_muscle_fatigue1.11456098
55MP0001664_abnormal_digestion1.06141530
56MP0005275_abnormal_skin_tensile1.05061689
57MP0005084_abnormal_gallbladder_morpholo1.04876418
58MP0001756_abnormal_urination1.03771922
59MP0003718_maternal_effect1.02723008
60MP0006054_spinal_hemorrhage1.02688502
61MP0002876_abnormal_thyroid_physiology1.00399191
62MP0003656_abnormal_erythrocyte_physiolo0.99888831
63MP0009764_decreased_sensitivity_to0.99075548
64MP0002971_abnormal_brown_adipose0.94110297
65MP0005535_abnormal_body_temperature0.92863768
66MP0005647_abnormal_sex_gland0.91497724
67MP0008961_abnormal_basal_metabolism0.91266857
68MP0002136_abnormal_kidney_physiology0.89509377
69MP0002638_abnormal_pupillary_reflex0.88179269
70MP0005666_abnormal_adipose_tissue0.88153106
71MP0004130_abnormal_muscle_cell0.87272083
72MP0005551_abnormal_eye_electrophysiolog0.86974815
73MP0006036_abnormal_mitochondrial_physio0.86344897
74MP0001765_abnormal_ion_homeostasis0.84589494
75MP0009763_increased_sensitivity_to0.83250897
76MP0000598_abnormal_liver_morphology0.82104032
77MP0005167_abnormal_blood-brain_barrier0.79757960
78MP0009642_abnormal_blood_homeostasis0.79494172
79MP0005377_hearing/vestibular/ear_phenot0.78283581
80MP0003878_abnormal_ear_physiology0.78283581
81MP0005058_abnormal_lysosome_morphology0.77804128
82MP0009115_abnormal_fat_cell0.77121898
83MP0002254_reproductive_system_inflammat0.74295569
84MP0000230_abnormal_systemic_arterial0.73624005
85MP0010155_abnormal_intestine_physiology0.73321104
86MP0002295_abnormal_pulmonary_circulatio0.73042195
87MP0008469_abnormal_protein_level0.73013348
88MP0009765_abnormal_xenobiotic_induced0.70368100
89MP0005334_abnormal_fat_pad0.70128386
90MP0002078_abnormal_glucose_homeostasis0.69938307
91MP0005376_homeostasis/metabolism_phenot0.69799080
92MP0003950_abnormal_plasma_membrane0.65132965
93MP0001879_abnormal_lymphatic_vessel0.63717876
94MP0004885_abnormal_endolymph0.63650759
95MP0000566_synostosis0.63637263
96MP0004782_abnormal_surfactant_physiolog0.61714076
97MP0000427_abnormal_hair_cycle0.60500202
98MP0005595_abnormal_vascular_smooth0.60248557
99MP0002837_dystrophic_cardiac_calcinosis0.59964541
100MP0004381_abnormal_hair_follicle0.57279518
101MP0003638_abnormal_response/metabolism_0.56665026
102MP0002277_abnormal_respiratory_mucosa0.54216717
103MP0004185_abnormal_adipocyte_glucose0.53851036
104MP0002135_abnormal_kidney_morphology0.53640549
105MP0000534_abnormal_ureter_morphology0.53639064
106MP0010352_gastrointestinal_tract_polyps0.53435604
107MP0005174_abnormal_tail_pigmentation0.52414828
108MP0002736_abnormal_nociception_after0.51981300
109MP0002168_other_aberrant_phenotype0.51499077
110MP0005164_abnormal_response_to0.51478559
111MP0005220_abnormal_exocrine_pancreas0.50983165
112MP0001324_abnormal_eye_pigmentation0.50364566
113MP0005395_other_phenotype0.49802333
114MP0001958_emphysema0.49437845
115MP0002735_abnormal_chemical_nociception0.49315385
116MP0000639_abnormal_adrenal_gland0.47122396
117MP0004272_abnormal_basement_membrane0.47025822
118MP0005409_darkened_coat_color0.46683251
119MP0005075_abnormal_melanosome_morpholog0.46653477
120MP0003633_abnormal_nervous_system0.46534070
121MP0001986_abnormal_taste_sensitivity0.46364472
122MP0000249_abnormal_blood_vessel0.45215185
123MP0004215_abnormal_myocardial_fiber0.44461596
124MP0002928_abnormal_bile_duct0.44252065
125MP0005375_adipose_tissue_phenotype0.43709726
126MP0003075_altered_response_to0.42834186
127MP0005448_abnormal_energy_balance0.42773518
128MP0004883_abnormal_blood_vessel0.42645982
129MP0008874_decreased_physiological_sensi0.41385325
130MP0009384_cardiac_valve_regurgitation0.40465805
131MP0003953_abnormal_hormone_level0.40454739
132MP0003866_abnormal_defecation0.39078908
133MP0005646_abnormal_pituitary_gland0.38709281
134MP0005266_abnormal_metabolism0.38553508
135MP0006082_CNS_inflammation0.38526248
136MP0005165_increased_susceptibility_to0.37858022
137MP0003631_nervous_system_phenotype0.37454304
138MP0005410_abnormal_fertilization0.36491654
139MP0002796_impaired_skin_barrier0.35972507
140MP0000026_abnormal_inner_ear0.35948341
141MP0000477_abnormal_intestine_morphology0.35703856
142MP0003632_abnormal_nervous_system0.35678071
143MP0000538_abnormal_urinary_bladder0.35492723
144MP0002822_catalepsy0.35301080
145MP0005166_decreased_susceptibility_to0.35156588
146MP0000516_abnormal_urinary_system0.34549215

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.50353739
2Intrahepatic cholestasis (HP:0001406)5.85099528
3Deep venous thrombosis (HP:0002625)5.63146963
4Xanthomatosis (HP:0000991)5.15566433
5Prolonged partial thromboplastin time (HP:0003645)4.88326439
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.81060826
7Acanthocytosis (HP:0001927)4.67926949
8Hyperlipoproteinemia (HP:0010980)4.61595613
9Facial shape deformation (HP:0011334)4.51401405
10Potter facies (HP:0002009)4.51401405
11Hyperglycinuria (HP:0003108)4.42756261
12Abnormality of glycine metabolism (HP:0010895)4.39355098
13Abnormality of serine family amino acid metabolism (HP:0010894)4.39355098
14Hypobetalipoproteinemia (HP:0003563)4.34966024
15Ketosis (HP:0001946)4.12857383
16Hyperammonemia (HP:0001987)4.10830291
17Pigmentary retinal degeneration (HP:0001146)4.10509599
18Hyperglycinemia (HP:0002154)4.08369517
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.97485432
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.91820308
21Abnormality of the vitamin B12 metabolism (HP:0004341)3.87412418
22Abnormality of fatty-acid metabolism (HP:0004359)3.80282695
23Complement deficiency (HP:0004431)3.79794999
24Joint hemorrhage (HP:0005261)3.72757502
25Abnormality of vitamin B metabolism (HP:0004340)3.67505975
26Hypoglycemic coma (HP:0001325)3.63608869
27Abnormality of magnesium homeostasis (HP:0004921)3.51122539
28Abnormality of methionine metabolism (HP:0010901)3.49297128
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.45089163
30Hypolipoproteinemia (HP:0010981)3.42196109
31Epidermoid cyst (HP:0200040)3.39018033
32Ketoacidosis (HP:0001993)3.38602690
33Ileus (HP:0002595)3.36696840
34Fat malabsorption (HP:0002630)3.36289111
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.34724141
36Widely patent fontanelles and sutures (HP:0004492)3.31356713
37Nausea (HP:0002018)3.25837316
38Chronic diarrhea (HP:0002028)3.22495791
39Hypoalphalipoproteinemia (HP:0003233)3.15914898
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.15262855
41Abnormality of the common coagulation pathway (HP:0010990)3.14357180
42Hypokalemic alkalosis (HP:0001949)3.12055727
43Decreased circulating renin level (HP:0003351)3.09300183
44Gout (HP:0001997)3.07170587
45Hypokalemia (HP:0002900)3.06943040
46Alkalosis (HP:0001948)3.05947926
47Conjugated hyperbilirubinemia (HP:0002908)3.02994348
48Delayed CNS myelination (HP:0002188)3.01691821
49Dicarboxylic aciduria (HP:0003215)3.00182693
50Abnormality of dicarboxylic acid metabolism (HP:0010995)3.00182693
51Vascular calcification (HP:0004934)2.98572473
52Abnormality of purine metabolism (HP:0004352)2.95883367
53Increased circulating renin level (HP:0000848)2.92654000
54Hyperaldosteronism (HP:0000859)2.88728975
55Amelogenesis imperfecta (HP:0000705)2.88138082
56Generalized aminoaciduria (HP:0002909)2.87747525
57Metabolic acidosis (HP:0001942)2.83845259
58Proximal tubulopathy (HP:0000114)2.79333182
59Abnormality of serum amino acid levels (HP:0003112)2.77082342
60Lethargy (HP:0001254)2.75415892
61Nephrolithiasis (HP:0000787)2.74345216
62Abnormality of nucleobase metabolism (HP:0010932)2.74242584
63Hypercholesterolemia (HP:0003124)2.72509352
64Abnormality of urine glucose concentration (HP:0011016)2.68965204
65Glycosuria (HP:0003076)2.68965204
66Hyperactive renin-angiotensin system (HP:0000841)2.68670376
67Enlarged epiphyses (HP:0010580)2.66472867
68Steatorrhea (HP:0002570)2.65616643
69Abnormality of the intrinsic pathway (HP:0010989)2.63569794
70Tetany (HP:0001281)2.61480411
71Cardiovascular calcification (HP:0011915)2.61313633
72Congenital sensorineural hearing impairment (HP:0008527)2.59549706
73Cerebral edema (HP:0002181)2.59495660
74Abnormality of potassium homeostasis (HP:0011042)2.57179350
75Hyperbilirubinemia (HP:0002904)2.56075573
76Megaloblastic anemia (HP:0001889)2.55289057
77Metabolic alkalosis (HP:0200114)2.54655747
78Hypophosphatemic rickets (HP:0004912)2.53440771
79Abnormality of complement system (HP:0005339)2.53403937
80Vomiting (HP:0002013)2.46333005
81Enlarged kidneys (HP:0000105)2.45425926
82Rickets (HP:0002748)2.42408195
83Hepatocellular carcinoma (HP:0001402)2.40010085
84Neurofibrillary tangles (HP:0002185)2.39515907
85Hypomagnesemia (HP:0002917)2.33330321
86Parakeratosis (HP:0001036)2.33227411
87Hypoglycemic seizures (HP:0002173)2.31746331
88Abnormality of pyrimidine metabolism (HP:0004353)2.30961017
89Irritability (HP:0000737)2.27676356
90Confusion (HP:0001289)2.27170693
91Increased purine levels (HP:0004368)2.26027379
92Hyperuricemia (HP:0002149)2.26027379
93Amyloidosis (HP:0011034)2.25781191
94Poikilocytosis (HP:0004447)2.21548301
95Cerebral hemorrhage (HP:0001342)2.21113835
96Hyperventilation (HP:0002883)2.18653196
97Malnutrition (HP:0004395)2.13018293
98Opisthotonus (HP:0002179)2.12547543
99Myocardial infarction (HP:0001658)2.11691576
100Pancreatitis (HP:0001733)2.10503051
101Cerebral palsy (HP:0100021)2.09561358
102Hydroxyprolinuria (HP:0003080)2.08852084
103Abnormality of proline metabolism (HP:0010907)2.08852084
104Hypophosphatemia (HP:0002148)2.08706560
105Chorioretinal atrophy (HP:0000533)2.08472043
106Polyuria (HP:0000103)2.07880270
107Wide cranial sutures (HP:0010537)2.01422438
108Abnormal urine output (HP:0012590)2.01394155
109Mitral stenosis (HP:0001718)2.00896999
110Methylmalonic aciduria (HP:0012120)2.00191055
111Long clavicles (HP:0000890)1.99926928
112Hyperphosphaturia (HP:0003109)1.99367494
113Hyperinsulinemic hypoglycemia (HP:0000825)1.99263009
114Renal cortical cysts (HP:0000803)1.97534105
115Systemic lupus erythematosus (HP:0002725)1.97145812
116Abnormality of chloride homeostasis (HP:0011422)1.96345642
117Dehydration (HP:0001944)1.96034561
118Esophageal varix (HP:0002040)1.95443329
119Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95429166
120Abnormality of vitamin metabolism (HP:0100508)1.94189867
121Osteomalacia (HP:0002749)1.93935598
122Spontaneous abortion (HP:0005268)1.93636272
123Ulnar claw (HP:0001178)1.93043522
124Pancreatic cysts (HP:0001737)1.92666336
125Abnormality of the renal cortex (HP:0011035)1.92351593
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.91871008
127Hypoplasia of the fovea (HP:0007750)1.91871008
128Brushfield spots (HP:0001088)1.91259977
129Skin nodule (HP:0200036)1.90785741
130Congenital ichthyosiform erythroderma (HP:0007431)1.89730368
131Hemorrhage of the eye (HP:0011885)1.89175467
132Abnormal gallbladder morphology (HP:0012437)1.86365604
133Abnormality of renal excretion (HP:0011036)1.86238425
134Glomerulonephritis (HP:0000099)1.85567639
135Abnormal urine phosphate concentration (HP:0012599)1.85318270
136Axonal loss (HP:0003447)1.85004054
137Tubular atrophy (HP:0000092)1.84373845
138Abnormality of renin-angiotensin system (HP:0000847)1.84292059
139Abnormal enzyme/coenzyme activity (HP:0012379)1.83741897
140Hypercalciuria (HP:0002150)1.82865870
141Renal salt wasting (HP:0000127)1.82718282
142Acute encephalopathy (HP:0006846)1.82408480
143Abnormal drinking behavior (HP:0030082)1.81665862
144Polydipsia (HP:0001959)1.81665862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.34388095
2BCKDK4.58348414
3STK394.57892144
4WNK43.96621835
5OXSR13.94948367
6INSRR2.91768662
7TIE12.88502663
8EPHB12.84616137
9FGFR42.70042028
10LATS22.41194740
11SIK12.41044574
12ZAK2.39298383
13FGFR22.33472136
14ADRBK22.04392888
15MET1.85005591
16MAPK151.81912327
17SGK4941.68726484
18SGK2231.68726484
19WNK31.68496864
20EIF2AK31.64779505
21ERBB41.64285336
22PKN11.55590304
23TAOK31.48174719
24PBK1.46840134
25ERN11.44225687
26MAP3K21.41750197
27KDR1.41454068
28MST1R1.40688507
29STK31.38374400
30PRKG21.35756734
31BCR1.25983661
32MST41.24075278
33WNK11.14606253
34MELK1.13559210
35PRKAA21.12578083
36PIK3CG1.12027330
37TGFBR11.11620373
38NUAK11.06107314
39GRK11.05273020
40STK381.04992861
41TGFBR21.04712493
42ADRBK10.97347101
43CSNK1G10.96913924
44GSK3A0.94730704
45EPHA30.94307864
46PRKCQ0.94106567
47PRKD30.92336606
48PINK10.88496429
49CSNK1A1L0.88112955
50FER0.85315852
51CSNK1G30.84945417
52PNCK0.84920821
53MAP3K140.82878066
54CAMK2G0.82494158
55CAMK1G0.81277056
56SGK20.78954839
57NEK90.78418053
58MAP4K20.78264835
59BMPR1B0.77002993
60PIK3CA0.76959700
61IRAK10.74576739
62PDPK10.74340491
63CAMK1D0.74216278
64SGK30.73853510
65MAP2K40.71830847
66IRAK20.71637226
67PDK20.71483432
68MAPK110.71301076
69MAPK120.71234059
70MAPKAPK50.70987585
71MAP3K70.70488872
72ABL20.68438559
73PRKD10.67137906
74DAPK20.66885499
75RIPK10.66344972
76NEK60.65627214
77TLK10.65522717
78CAMK2B0.65164848
79CSK0.64713097
80MAPK70.62318957
81LATS10.62073574
82MYLK0.61707499
83MAPK130.60178317
84KIT0.58785718
85MUSK0.57589016
86CSNK1G20.57406645
87NTRK10.57117350
88LMTK20.56730198
89AKT30.55680872
90MAP2K20.54973596
91NEK20.54731751
92CAMK2D0.54349374
93ICK0.54035425
94ITK0.53249815
95PAK30.52793461
96MAPK40.52288060
97PRKCG0.52001810
98TYK20.51539458
99PRKCE0.51253471
100MAP2K60.49325826
101EPHB20.48990534
102PRKACG0.48721765
103FRK0.48545980
104GRK70.48030636
105JAK20.47651687
106EPHA40.46975434
107IGF1R0.46687843
108PRKCZ0.46387752
109PDK40.46224914
110PDK30.46224914
111PRKCA0.46063151
112VRK10.45636047
113JAK10.44543163
114OBSCN0.44194286
115MAP3K30.44118619
116STK38L0.43100625
117MAP2K30.41317735
118NLK0.41144879
119PTK2B0.40341968
120CAMK2A0.39395461
121PIM10.38822205
122CSNK1A10.38320986
123ERBB20.37995414
124PRKACA0.37729723
125NTRK30.37278591
126PRKAA10.37113700
127TEC0.36822405
128ROCK20.36550577
129PRKCH0.36255248
130TNIK0.36114375
131FGR0.35765578
132MAP3K120.35699603
133PRKD20.35633201
134CASK0.34711360
135GRK50.34304506
136MAP2K10.34198568
137TAF10.30572474
138STK110.30549490
139TYRO30.29753344
140DDR20.28959237
141TNK20.27235468
142PRKCD0.26115079
143TXK0.24271196
144WEE10.24070667
145NME10.22811869
146MATK0.22465808
147PRKCI0.21733181

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.64843419
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10293396
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.90577336
4Nitrogen metabolism_Homo sapiens_hsa009102.89859440
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82972299
6Butanoate metabolism_Homo sapiens_hsa006502.59447976
7Fatty acid degradation_Homo sapiens_hsa000712.58960321
8Tryptophan metabolism_Homo sapiens_hsa003802.52767698
9Propanoate metabolism_Homo sapiens_hsa006402.50404832
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45685060
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45008158
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43131234
13* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.33477704
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29419841
15Fatty acid elongation_Homo sapiens_hsa000622.29158907
16Arginine biosynthesis_Homo sapiens_hsa002202.29005495
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24112376
18Peroxisome_Homo sapiens_hsa041462.22212413
19Complement and coagulation cascades_Homo sapiens_hsa046102.13235908
20Histidine metabolism_Homo sapiens_hsa003402.12504428
21Fatty acid metabolism_Homo sapiens_hsa012122.11636115
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01749506
23Chemical carcinogenesis_Homo sapiens_hsa052041.97667059
24Sulfur metabolism_Homo sapiens_hsa009201.96248608
25beta-Alanine metabolism_Homo sapiens_hsa004101.89285659
26Steroid biosynthesis_Homo sapiens_hsa001001.87704156
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.87541149
28PPAR signaling pathway_Homo sapiens_hsa033201.86330521
29Retinol metabolism_Homo sapiens_hsa008301.78302681
30Pyruvate metabolism_Homo sapiens_hsa006201.53885990
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50947449
32Caffeine metabolism_Homo sapiens_hsa002321.48365278
33Phenylalanine metabolism_Homo sapiens_hsa003601.46618218
34Tyrosine metabolism_Homo sapiens_hsa003501.45739873
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43293809
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41241182
37Bile secretion_Homo sapiens_hsa049761.38379305
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37359087
39Staphylococcus aureus infection_Homo sapiens_hsa051501.28086135
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.28046486
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21668371
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20868531
43Vitamin digestion and absorption_Homo sapiens_hsa049771.19936872
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18145016
45Selenocompound metabolism_Homo sapiens_hsa004501.17485507
46Arginine and proline metabolism_Homo sapiens_hsa003301.16275406
47ABC transporters_Homo sapiens_hsa020101.12891019
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12835570
49Starch and sucrose metabolism_Homo sapiens_hsa005001.12791621
50Folate biosynthesis_Homo sapiens_hsa007901.11584598
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09194888
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98655085
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.98417937
54Carbon metabolism_Homo sapiens_hsa012000.96741516
55Glutathione metabolism_Homo sapiens_hsa004800.96246852
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.94318356
57Phototransduction_Homo sapiens_hsa047440.92944802
58Fat digestion and absorption_Homo sapiens_hsa049750.92593771
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.89481200
60Glycerolipid metabolism_Homo sapiens_hsa005610.87238883
61Vitamin B6 metabolism_Homo sapiens_hsa007500.83783880
62Sulfur relay system_Homo sapiens_hsa041220.82324086
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72568589
64Biosynthesis of amino acids_Homo sapiens_hsa012300.70476854
65Lysine degradation_Homo sapiens_hsa003100.70284352
66Fatty acid biosynthesis_Homo sapiens_hsa000610.69069930
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68450772
68Metabolic pathways_Homo sapiens_hsa011000.56189221
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54517857
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52315355
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51903638
72Linoleic acid metabolism_Homo sapiens_hsa005910.47987913
73Pentose phosphate pathway_Homo sapiens_hsa000300.39142050
74Ether lipid metabolism_Homo sapiens_hsa005650.38500698
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37333256
76Serotonergic synapse_Homo sapiens_hsa047260.36952537
77Taste transduction_Homo sapiens_hsa047420.35148854
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30325516
79Asthma_Homo sapiens_hsa053100.29357559
80Dorso-ventral axis formation_Homo sapiens_hsa043200.28522445
81Oxidative phosphorylation_Homo sapiens_hsa001900.27378052
82Pancreatic secretion_Homo sapiens_hsa049720.24453542
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24290128
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.23485306
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.22490594
86Nicotine addiction_Homo sapiens_hsa050330.22436788
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22389674
88Arachidonic acid metabolism_Homo sapiens_hsa005900.21747258
89N-Glycan biosynthesis_Homo sapiens_hsa005100.21369203
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.18557516
91Protein export_Homo sapiens_hsa030600.14633684
92TGF-beta signaling pathway_Homo sapiens_hsa043500.13325989
93Mineral absorption_Homo sapiens_hsa049780.12093326
94Insulin resistance_Homo sapiens_hsa049310.10790820
95Ovarian steroidogenesis_Homo sapiens_hsa049130.08786191
96Glucagon signaling pathway_Homo sapiens_hsa049220.07820154
97Prion diseases_Homo sapiens_hsa050200.06350445
98Parkinsons disease_Homo sapiens_hsa050120.06162255
99Sphingolipid metabolism_Homo sapiens_hsa006000.06043743
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.05732983
101Cocaine addiction_Homo sapiens_hsa050300.04807025
102Renin secretion_Homo sapiens_hsa049240.04317583
103Alzheimers disease_Homo sapiens_hsa050100.03932987
104Fructose and mannose metabolism_Homo sapiens_hsa000510.02197837
105Renin-angiotensin system_Homo sapiens_hsa046140.01731158
106Protein digestion and absorption_Homo sapiens_hsa049740.00766415
107Lysosome_Homo sapiens_hsa041420.00256424
108Collecting duct acid secretion_Homo sapiens_hsa04966-0.1036183
109Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0905375
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0889006
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0851161
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0836410
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0705480
114Galactose metabolism_Homo sapiens_hsa00052-0.0596367
115Regulation of autophagy_Homo sapiens_hsa04140-0.0327358
116AMPK signaling pathway_Homo sapiens_hsa04152-0.0137020
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0118107
118One carbon pool by folate_Homo sapiens_hsa00670-0.0048947
119Other glycan degradation_Homo sapiens_hsa00511-0.0015014

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