FMO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)6.91050348
2chemical homeostasis within a tissue (GO:0048875)5.44991056
3peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.42931690
4positive regulation of endothelial cell differentiation (GO:0045603)4.83168212
5drug catabolic process (GO:0042737)4.73389352
6regulation of endothelial cell differentiation (GO:0045601)4.71584345
7xenobiotic catabolic process (GO:0042178)4.67961131
8exogenous drug catabolic process (GO:0042738)4.53505477
9urate metabolic process (GO:0046415)4.30183427
10negative regulation of complement activation (GO:0045916)4.27894800
11cysteine metabolic process (GO:0006534)4.08887151
12homocysteine metabolic process (GO:0050667)4.06167949
13drug transmembrane transport (GO:0006855)4.03863723
14lysine metabolic process (GO:0006553)4.01962406
15lysine catabolic process (GO:0006554)4.01962406
16response to nitrosative stress (GO:0051409)3.99906026
17negative regulation of humoral immune response (GO:0002921)3.88609230
18epoxygenase P450 pathway (GO:0019373)3.84753409
19ethanol oxidation (GO:0006069)3.81376187
20polyol transport (GO:0015791)3.80554143
21negative regulation of protein activation cascade (GO:2000258)3.78960806
22phosphate ion transport (GO:0006817)3.76988621
23positive regulation of digestive system process (GO:0060456)3.74452701
24hormone catabolic process (GO:0042447)3.72589886
25phosphate ion transmembrane transport (GO:0035435)3.71236890
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.67647160
27L-phenylalanine catabolic process (GO:0006559)3.67647160
28blood vessel maturation (GO:0001955)3.63297209
29regulation of sequestering of triglyceride (GO:0010889)3.60124862
30L-phenylalanine metabolic process (GO:0006558)3.58662545
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.58662545
32glyoxylate metabolic process (GO:0046487)3.58628778
33lymphangiogenesis (GO:0001946)3.58502351
34sulfur amino acid catabolic process (GO:0000098)3.52511498
35myofibril assembly (GO:0030239)3.52366912
36response to mercury ion (GO:0046689)3.50963538
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49968862
38flavonoid metabolic process (GO:0009812)3.48392660
39morphogenesis of an endothelium (GO:0003159)3.42295119
40endothelial tube morphogenesis (GO:0061154)3.42295119
41regulation of vasculogenesis (GO:2001212)3.41837469
42positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.40893603
43cardiac myofibril assembly (GO:0055003)3.40455409
44induction of positive chemotaxis (GO:0050930)3.39067947
45cellular response to nitric oxide (GO:0071732)3.37914408
46cellular response to epinephrine stimulus (GO:0071872)3.31812286
47* drug metabolic process (GO:0017144)3.30749940
48fatty acid beta-oxidation (GO:0006635)3.30001144
49drug transport (GO:0015893)3.25991412
50valine metabolic process (GO:0006573)3.25884165
51peptide catabolic process (GO:0043171)3.25470938
52cilium or flagellum-dependent cell motility (GO:0001539)3.24929165
53muscle filament sliding (GO:0030049)3.22776769
54actin-myosin filament sliding (GO:0033275)3.22776769
55renal absorption (GO:0070293)3.20430743
56transcytosis (GO:0045056)3.19378176
57regulation of integrin-mediated signaling pathway (GO:2001044)3.18929060
58alpha-linolenic acid metabolic process (GO:0036109)3.18696400
59short-chain fatty acid metabolic process (GO:0046459)3.17353469
60benzene-containing compound metabolic process (GO:0042537)3.16677101
61endocrine hormone secretion (GO:0060986)3.15268256
62aromatic amino acid family catabolic process (GO:0009074)3.15117769
63low-density lipoprotein particle clearance (GO:0034383)3.14076331
64cGMP-mediated signaling (GO:0019934)3.13766094
65fatty acid oxidation (GO:0019395)3.13455713
66response to nitric oxide (GO:0071731)3.12623475
67axonemal dynein complex assembly (GO:0070286)3.11812209
68lung vasculature development (GO:0060426)3.11795903
69cellular glucuronidation (GO:0052695)3.09600287
70negative regulation of fibrinolysis (GO:0051918)3.09537591
71amino-acid betaine metabolic process (GO:0006577)3.08278882
72glomerular filtration (GO:0003094)3.07731895
73sarcomere organization (GO:0045214)3.07331819
74complement activation, alternative pathway (GO:0006957)3.07227882
75lipid oxidation (GO:0034440)3.06436114
76response to xenobiotic stimulus (GO:0009410)3.06177938
77uronic acid metabolic process (GO:0006063)3.03908112
78glucuronate metabolic process (GO:0019585)3.03908112
79regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.02504136
80primary alcohol catabolic process (GO:0034310)3.02384018
81phenylpropanoid metabolic process (GO:0009698)2.99604143
82triglyceride catabolic process (GO:0019433)2.99041699
83lymph vessel development (GO:0001945)2.98925134
84response to epinephrine (GO:0071871)2.97511926
85ethanol metabolic process (GO:0006067)2.97004454
86fibroblast migration (GO:0010761)2.94389645
87regulation of cholesterol storage (GO:0010885)2.93439324
88positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.93205537
89glutathione derivative metabolic process (GO:1901685)2.92569227
90glutathione derivative biosynthetic process (GO:1901687)2.92569227
91quaternary ammonium group transport (GO:0015697)2.92176918
92sodium-independent organic anion transport (GO:0043252)2.92033847
93fatty acid catabolic process (GO:0009062)2.90387676
94actin-mediated cell contraction (GO:0070252)2.88270528
95regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.87469963
96cellular response to reactive nitrogen species (GO:1902170)2.86717580
97regulation of cholesterol homeostasis (GO:2000188)2.86136257
98extracellular matrix assembly (GO:0085029)2.84652734
99positive regulation of vasculogenesis (GO:2001214)2.84281795
100barbed-end actin filament capping (GO:0051016)2.81793516
101carnitine metabolic process (GO:0009437)2.81549388
102cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.80503954
103cell migration involved in heart development (GO:0060973)2.78834861
104artery development (GO:0060840)2.78470813
105regulation of complement activation (GO:0030449)2.77095978
106apoptotic cell clearance (GO:0043277)2.77063884
107monocarboxylic acid catabolic process (GO:0072329)2.76942401
108lung lobe morphogenesis (GO:0060463)2.76212371
109tricarboxylic acid metabolic process (GO:0072350)2.75070424
110respiratory gaseous exchange (GO:0007585)2.75002980
111regulation of protein activation cascade (GO:2000257)2.74935782
112fatty acid transmembrane transport (GO:1902001)2.72326770
113motile cilium assembly (GO:0044458)2.71979301
114vascular endothelial growth factor signaling pathway (GO:0038084)2.71181583
115indolalkylamine catabolic process (GO:0046218)2.69483314
116tryptophan catabolic process (GO:0006569)2.69483314
117indole-containing compound catabolic process (GO:0042436)2.69483314
118regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.68605497
119branched-chain amino acid metabolic process (GO:0009081)2.68357849
120keratan sulfate catabolic process (GO:0042340)2.68183346
121phosphate ion homeostasis (GO:0055062)2.67589395
122trivalent inorganic anion homeostasis (GO:0072506)2.67589395
123extracellular fibril organization (GO:0043206)2.66699148
124actomyosin structure organization (GO:0031032)2.66676421
1252-oxoglutarate metabolic process (GO:0006103)2.65128634
126organic cation transport (GO:0015695)2.65101890
127regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.64767559
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64132768
129negative regulation of protein localization to cell surface (GO:2000009)2.64040395
130positive regulation of p38MAPK cascade (GO:1900745)2.63619331
131bile acid biosynthetic process (GO:0006699)2.63213268
132vitamin D metabolic process (GO:0042359)2.62736245
133midgut development (GO:0007494)2.61992348
134neutral lipid catabolic process (GO:0046461)2.61954828
135acylglycerol catabolic process (GO:0046464)2.61954828
136aspartate family amino acid catabolic process (GO:0009068)2.61910786
137negative regulation of norepinephrine secretion (GO:0010700)2.60848630
138renal filtration (GO:0097205)2.60461148
139cardiac muscle contraction (GO:0060048)2.60093291
140one-carbon compound transport (GO:0019755)2.59358048
141peptidyl-glutamic acid carboxylation (GO:0017187)2.59030266
142protein carboxylation (GO:0018214)2.59030266
143tryptophan metabolic process (GO:0006568)2.58900043
144endothelial cell morphogenesis (GO:0001886)2.58505043
145neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.58169827
146excretion (GO:0007588)2.58137559
147carnitine transport (GO:0015879)2.57579562
148amino-acid betaine transport (GO:0015838)2.57579562
149bundle of His cell to Purkinje myocyte communication (GO:0086069)2.57329844
150L-ascorbic acid metabolic process (GO:0019852)2.56382894
151retina vasculature morphogenesis in camera-type eye (GO:0061299)2.55659371
152iron ion import (GO:0097286)2.53953876
153protein localization to cell surface (GO:0034394)2.52128420
154ovulation from ovarian follicle (GO:0001542)2.51823072
155regulation of macrophage derived foam cell differentiation (GO:0010743)2.50392270
156complement activation (GO:0006956)2.47753164
157actin filament-based movement (GO:0030048)2.46359479
158regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.45441225
159growth hormone receptor signaling pathway (GO:0060396)2.42657150
160cell volume homeostasis (GO:0006884)2.41907948
161fibril organization (GO:0097435)2.41060641
162positive regulation of lipid storage (GO:0010884)2.40550810
163skeletal muscle adaptation (GO:0043501)2.40308626
164NADH metabolic process (GO:0006734)2.39270356
165endothelium development (GO:0003158)2.39152634
166cellular response to dexamethasone stimulus (GO:0071549)2.36016562
167cardiac muscle hypertrophy (GO:0003300)2.34929710
168negative regulation of actin filament bundle assembly (GO:0032232)2.33368296
169positive regulation of catecholamine secretion (GO:0033605)2.30884816
170negative regulation of stress fiber assembly (GO:0051497)2.30764985
171regulation of p38MAPK cascade (GO:1900744)2.29779873
172striated muscle hypertrophy (GO:0014897)2.28576180
173complement activation, classical pathway (GO:0006958)2.28241246
174import into cell (GO:0098657)2.27569399
175cilium movement (GO:0003341)2.27186306
176primary alcohol metabolic process (GO:0034308)2.26211662
177regulation of cell communication by electrical coupling (GO:0010649)2.26169576
178sarcoplasmic reticulum calcium ion transport (GO:0070296)2.25924185
179heart contraction (GO:0060047)2.25180211
180heart process (GO:0003015)2.25180211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.10572041
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81808834
3GATA1_22025678_ChIP-Seq_K562_Human3.96475715
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.90369463
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.50360180
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.35098046
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.33872213
8* CLOCK_20551151_ChIP-Seq_293T_Human3.19349487
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.02949008
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.95261232
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.50124100
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49768239
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.45912710
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.42932611
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.36377822
16* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.18687648
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.17255256
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.06999309
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99789196
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.90397877
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.87957975
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83783419
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72765305
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68415148
25* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65023389
26BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.62484406
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58907243
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57593405
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56946451
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56846033
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.56318803
32NFIB_24661679_ChIP-Seq_LUNG_Mouse1.52796910
33SOX2_20726797_ChIP-Seq_SW620_Human1.51771974
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.47374430
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45561255
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.43886687
37EZH2_22144423_ChIP-Seq_EOC_Human1.42588645
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.41875966
39TBX20_22328084_ChIP-Seq_HEART_Mouse1.41875966
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41242391
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39444526
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37000944
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.35960943
44CJUN_26792858_Chip-Seq_BT549_Human1.35913488
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.33302136
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32116470
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31331703
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30673801
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28808478
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28199745
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28199745
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.27392358
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26491891
54GATA4_25053715_ChIP-Seq_YYC3_Human1.25198526
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24697029
56AHR_22903824_ChIP-Seq_MCF-7_Human1.23535545
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23064637
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22578153
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20114464
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15411731
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15303565
62DROSHA_22980978_ChIP-Seq_HELA_Human1.15293935
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15166157
64AR_21572438_ChIP-Seq_LNCaP_Human1.15092299
65ZNF263_19887448_ChIP-Seq_K562_Human1.13082374
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12724243
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10675443
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10636985
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10351668
70RACK7_27058665_Chip-Seq_MCF-7_Human1.10297254
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08873591
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08526723
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08489175
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08130071
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06982045
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06156708
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05172681
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.02384909
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01752291
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01572405
81* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01489323
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01440570
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00556688
84EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98635121
85RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98635121
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.98234044
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97686037
88GATA1_19941826_ChIP-Seq_K562_Human0.97251218
89BCAT_22108803_ChIP-Seq_LS180_Human0.96399523
90HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96012140
91RXR_22108803_ChIP-Seq_LS180_Human0.94513232
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94017529
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93399463
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92763754
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92763754
96RUNX1_27514584_Chip-Seq_MCF-7_Human0.92083748
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.91792790
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.91579982
99EED_16625203_ChIP-ChIP_MESCs_Mouse0.91266678
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91169035
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91134273
102P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90929226
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90736054
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.90502466
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88415826
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87642458
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.87014959
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86283818
109GATA3_24758297_ChIP-Seq_MCF-7_Human0.86254506
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85996802
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85881054
112TP63_23658742_ChIP-Seq_EP156T_Human0.85791158
113IRF8_22096565_ChIP-ChIP_GC-B_Human0.85059918
114GATA6_25053715_ChIP-Seq_YYC3_Human0.84677838
115* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84365995
116SMAD4_21799915_ChIP-Seq_A2780_Human0.83754868
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83568793
118LXR_22292898_ChIP-Seq_THP-1_Human0.83153534
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82879426
120GATA2_19941826_ChIP-Seq_K562_Human0.82572363
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82343184
122TP53_18474530_ChIP-ChIP_U2OS_Human0.81713988
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81390029
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80301762
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78940316
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.78423757
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77175457
128JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77090391
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77016536
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76565902
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75712791
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.74639348
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72677519
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71716436
135HNF4A_19822575_ChIP-Seq_HepG2_Human0.71640103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.39750925
2MP0002139_abnormal_hepatobiliary_system4.82733512
3MP0008875_abnormal_xenobiotic_pharmacok4.47413312
4MP0005360_urolithiasis4.34765933
5MP0001958_emphysema3.68091933
6MP0010368_abnormal_lymphatic_system3.62639013
7MP0005365_abnormal_bile_salt2.94601579
8MP0004782_abnormal_surfactant_physiolog2.93162863
9MP0005503_abnormal_tendon_morphology2.85440385
10MP0000751_myopathy2.82418570
11MP0005085_abnormal_gallbladder_physiolo2.78699786
12MP0001879_abnormal_lymphatic_vessel2.67704368
13MP0003252_abnormal_bile_duct2.52099956
14MP0003191_abnormal_cellular_cholesterol2.46784301
15MP0003724_increased_susceptibility_to2.43697899
16MP0005332_abnormal_amino_acid2.38839223
17MP0005167_abnormal_blood-brain_barrier2.33907746
18MP0004215_abnormal_myocardial_fiber2.30025607
19MP0004019_abnormal_vitamin_homeostasis2.26328900
20MP0005083_abnormal_biliary_tract2.04107215
21MP0009643_abnormal_urine_homeostasis2.00178623
22MP0004043_abnormal_pH_regulation1.97300785
23MP0010329_abnormal_lipoprotein_level1.93312562
24MP0001542_abnormal_bone_strength1.88695443
25MP0004272_abnormal_basement_membrane1.88006074
26MP0002108_abnormal_muscle_morphology1.85108533
27MP0005375_adipose_tissue_phenotype1.83155004
28MP0008775_abnormal_heart_ventricle1.79374355
29MP0001756_abnormal_urination1.77366530
30MP0003950_abnormal_plasma_membrane1.72454004
31MP0000749_muscle_degeneration1.66338638
32MP0004087_abnormal_muscle_fiber1.65567389
33MP0005275_abnormal_skin_tensile1.63983719
34MP0001661_extended_life_span1.59537672
35MP0003195_calcinosis1.56008490
36MP0003705_abnormal_hypodermis_morpholog1.54312433
37MP0003300_gastrointestinal_ulcer1.53995305
38MP0008438_abnormal_cutaneous_collagen1.51811873
39MP0003806_abnormal_nucleotide_metabolis1.51811196
40MP0005620_abnormal_muscle_contractility1.50269783
41MP0000013_abnormal_adipose_tissue1.47642133
42MP0002136_abnormal_kidney_physiology1.40601771
43MP0001765_abnormal_ion_homeostasis1.37465812
44MP0002295_abnormal_pulmonary_circulatio1.37073785
45MP0003566_abnormal_cell_adhesion1.35103085
46MP0010234_abnormal_vibrissa_follicle1.32154396
47MP0002127_abnormal_cardiovascular_syste1.29371237
48MP0003186_abnormal_redox_activity1.27662895
49MP0002118_abnormal_lipid_homeostasis1.27477249
50MP0006138_congestive_heart_failure1.27381500
51MP0000759_abnormal_skeletal_muscle1.25763727
52MP0001851_eye_inflammation1.25489129
53MP0010630_abnormal_cardiac_muscle1.25162820
54MP0009764_decreased_sensitivity_to1.25109617
55MP0005670_abnormal_white_adipose1.24736527
56MP0005319_abnormal_enzyme/_coenzyme1.24528186
57MP0001666_abnormal_nutrient_absorption1.24083618
58MP0009115_abnormal_fat_cell1.23606458
59MP0005636_abnormal_mineral_homeostasis1.22132052
60MP0002133_abnormal_respiratory_system1.21059936
61MP0005388_respiratory_system_phenotype1.21059936
62MP0000343_altered_response_to1.20360155
63MP0008995_early_reproductive_senescence1.18271304
64MP0002132_abnormal_respiratory_system1.17845784
65MP0000003_abnormal_adipose_tissue1.16883549
66MP0004085_abnormal_heartbeat1.14806640
67MP0003690_abnormal_glial_cell1.13535291
68MP0005164_abnormal_response_to1.13456968
69MP0005084_abnormal_gallbladder_morpholo1.13266605
70MP0005595_abnormal_vascular_smooth1.11290672
71MP0002168_other_aberrant_phenotype1.11077162
72MP0002998_abnormal_bone_remodeling1.09309364
73MP0005397_hematopoietic_system_phenotyp1.08026586
74MP0001545_abnormal_hematopoietic_system1.08026586
75MP0000249_abnormal_blood_vessel1.07185626
76MP0004130_abnormal_muscle_cell1.05636995
77MP0000767_abnormal_smooth_muscle1.05521925
78MP0000609_abnormal_liver_physiology1.03121753
79MP0003646_muscle_fatigue1.02929052
80MP0005369_muscle_phenotype1.02411561
81MP0002269_muscular_atrophy1.02310883
82MP0004185_abnormal_adipocyte_glucose1.02236129
83MP0003137_abnormal_impulse_conducting1.00980079
84MP0009840_abnormal_foam_cell1.00774146
85MP0009780_abnormal_chondrocyte_physiolo1.00703296
86MP0003828_pulmonary_edema1.00444520
87MP0005165_increased_susceptibility_to1.00318768
88MP0004883_abnormal_blood_vessel1.00099733
89MP0005584_abnormal_enzyme/coenzyme_acti0.99738088
90MP0000230_abnormal_systemic_arterial0.98479812
91MP0000747_muscle_weakness0.93725375
92MP0002254_reproductive_system_inflammat0.93596015
93MP0005385_cardiovascular_system_phenoty0.92934663
94MP0001544_abnormal_cardiovascular_syste0.92934663
95MP0005408_hypopigmentation0.91664480
96MP0002928_abnormal_bile_duct0.89802278
97MP0005334_abnormal_fat_pad0.89177376
98MP0006054_spinal_hemorrhage0.88948168
99MP0003279_aneurysm0.87294918
100MP0001177_atelectasis0.86524917
101MP0002933_joint_inflammation0.86174613
102MP0004084_abnormal_cardiac_muscle0.84004138
103MP0005647_abnormal_sex_gland0.83087479
104MP0008004_abnormal_stomach_pH0.82643439
105MP0002796_impaired_skin_barrier0.82484239
106MP0009278_abnormal_bone_marrow0.81206623
107MP0002106_abnormal_muscle_physiology0.81146961
108MP0003075_altered_response_to0.79226997
109MP0000534_abnormal_ureter_morphology0.79105905
110MP0000465_gastrointestinal_hemorrhage0.78268574
111MP0005666_abnormal_adipose_tissue0.78124976
112MP0005058_abnormal_lysosome_morphology0.76288047
113MP0005535_abnormal_body_temperature0.76118649
114MP0004510_myositis0.75769548
115MP0002135_abnormal_kidney_morphology0.75233032
116MP0002837_dystrophic_cardiac_calcinosis0.74924757
117MP0005023_abnormal_wound_healing0.74087161
118MP0008961_abnormal_basal_metabolism0.72484534
119MP0001614_abnormal_blood_vessel0.71963148
120MP0003959_abnormal_lean_body0.70380641
121MP0000750_abnormal_muscle_regeneration0.68893777
122MP0000537_abnormal_urethra_morphology0.66727362
123MP0004036_abnormal_muscle_relaxation0.66043269
124MP0003638_abnormal_response/metabolism_0.65952619
125MP0005220_abnormal_exocrine_pancreas0.65866891
126MP0005508_abnormal_skeleton_morphology0.65819499
127MP0004484_altered_response_of0.65634710
128MP0000681_abnormal_thyroid_gland0.65466335
129MP0001501_abnormal_sleep_pattern0.65322935
130MP0003045_fibrosis0.65253765
131MP0002128_abnormal_blood_circulation0.65206416
132MP0002332_abnormal_exercise_endurance0.64316553
133MP0001175_abnormal_lung_morphology0.63138473
134MP0005166_decreased_susceptibility_to0.62587966
135MP0000266_abnormal_heart_morphology0.61898242
136MP0005330_cardiomyopathy0.61228843
137MP0002925_abnormal_cardiovascular_devel0.60295983
138MP0002972_abnormal_cardiac_muscle0.58137863
139MP0002971_abnormal_brown_adipose0.57779696
140MP0005376_homeostasis/metabolism_phenot0.57297146
141MP0004147_increased_porphyrin_level0.57279633
142MP0003453_abnormal_keratinocyte_physiol0.56910565
143MP0000598_abnormal_liver_morphology0.55424831
144MP0001270_distended_abdomen0.54842422
145MP0008469_abnormal_protein_level0.53542790
146MP0009642_abnormal_blood_homeostasis0.53408214
147MP0003091_abnormal_cell_migration0.52720875

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.42794753
2Polycythemia (HP:0001901)5.04960308
3Gout (HP:0001997)5.01464355
4Hypokalemic alkalosis (HP:0001949)4.44332346
5Renal salt wasting (HP:0000127)4.16946037
6Interstitial pulmonary disease (HP:0006530)4.09529921
7Deep venous thrombosis (HP:0002625)4.02313821
8Hematochezia (HP:0002573)4.01223353
9Hyporeflexia of lower limbs (HP:0002600)3.92694259
10Sudden death (HP:0001699)3.92641184
11Esophageal varix (HP:0002040)3.87802962
12Facial shape deformation (HP:0011334)3.85152203
13Potter facies (HP:0002009)3.85152203
14Abnormality of chloride homeostasis (HP:0011422)3.84868530
15Spontaneous hematomas (HP:0007420)3.73463414
16Hyperaldosteronism (HP:0000859)3.66040392
17Abnormality of renin-angiotensin system (HP:0000847)3.54165126
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.53924211
19Vascular calcification (HP:0004934)3.48799632
20Abnormality of purine metabolism (HP:0004352)3.46330721
21Increased variability in muscle fiber diameter (HP:0003557)3.43797923
22Abnormal ciliary motility (HP:0012262)3.42345913
23Hyperkalemia (HP:0002153)3.42277203
24Tubulointerstitial fibrosis (HP:0005576)3.40404380
25Increased connective tissue (HP:0009025)3.37991825
26Vascular tortuosity (HP:0004948)3.37758953
27Hyperglycinuria (HP:0003108)3.37478192
28Rhinitis (HP:0012384)3.33799493
29Cardiovascular calcification (HP:0011915)3.33378804
30Abnormality of the nasal mucosa (HP:0000433)3.31648793
31Exercise-induced myalgia (HP:0003738)3.31572173
32Dynein arm defect of respiratory motile cilia (HP:0012255)3.27286161
33Absent/shortened dynein arms (HP:0200106)3.27286161
34Abnormal respiratory motile cilium physiology (HP:0012261)3.21313596
35Hyperuricemia (HP:0002149)3.19646884
36Increased purine levels (HP:0004368)3.19646884
37Abnormality of glutamine family amino acid metabolism (HP:0010902)3.19432095
38Distal lower limb muscle weakness (HP:0009053)3.17785020
39Asymmetric septal hypertrophy (HP:0001670)3.17065958
40Abnormality of skeletal muscle fiber size (HP:0012084)3.14610482
41Glomerulonephritis (HP:0000099)3.07318668
42Arterial tortuosity (HP:0005116)3.06644336
43Type 1 muscle fiber predominance (HP:0003803)3.04916539
44Visceral angiomatosis (HP:0100761)3.04857755
45Increased circulating renin level (HP:0000848)3.03879719
46Abnormal respiratory motile cilium morphology (HP:0005938)3.00409164
47Abnormal respiratory epithelium morphology (HP:0012253)3.00409164
48Alkalosis (HP:0001948)2.98994300
49Ventricular tachycardia (HP:0004756)2.98081891
50Lipoatrophy (HP:0100578)2.97466563
51Metabolic alkalosis (HP:0200114)2.95756002
52Atrial fibrillation (HP:0005110)2.93593139
53Generalized aminoaciduria (HP:0002909)2.92954874
54Abnormality of renal excretion (HP:0011036)2.91959722
55Neck muscle weakness (HP:0000467)2.90809654
56Chronic bronchitis (HP:0004469)2.89861962
57Bundle branch block (HP:0011710)2.89614493
58Abnormality of the calf musculature (HP:0001430)2.88912081
59Ketoacidosis (HP:0001993)2.84003380
60Hemangiomatosis (HP:0007461)2.80437148
61Pulmonary artery stenosis (HP:0004415)2.79234397
62Abnormality of glycine metabolism (HP:0010895)2.79151824
63Abnormality of serine family amino acid metabolism (HP:0010894)2.79151824
64EMG: myopathic abnormalities (HP:0003458)2.76965693
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76317364
66Cerebral hemorrhage (HP:0001342)2.75954991
67Abnormality of the fingertips (HP:0001211)2.75640705
68Abnormal urine output (HP:0012590)2.75619694
69Right ventricular cardiomyopathy (HP:0011663)2.75554323
70Proximal tubulopathy (HP:0000114)2.73402860
71Tachypnea (HP:0002789)2.73018132
72Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72484666
73Complement deficiency (HP:0004431)2.72349246
74Ketosis (HP:0001946)2.72109408
75Frequent falls (HP:0002359)2.69302784
76Xanthomatosis (HP:0000991)2.67117374
77Intrahepatic cholestasis (HP:0001406)2.65471250
78Growth hormone excess (HP:0000845)2.65014400
79Primary atrial arrhythmia (HP:0001692)2.62348497
80Acanthosis nigricans (HP:0000956)2.57340351
81Spinal rigidity (HP:0003306)2.56812764
82Atrioventricular block (HP:0001678)2.55482599
83Protrusio acetabuli (HP:0003179)2.55029099
84Abnormality of fatty-acid metabolism (HP:0004359)2.53048323
85Syncope (HP:0001279)2.50647595
86Difficulty running (HP:0009046)2.48525972
87Supraventricular tachycardia (HP:0004755)2.46819681
88Abnormality of nucleobase metabolism (HP:0010932)2.46308947
89Hyperammonemia (HP:0001987)2.43931479
90Supraventricular arrhythmia (HP:0005115)2.43665814
91Scapular winging (HP:0003691)2.42540582
92Aortic dissection (HP:0002647)2.42049850
93Hypomagnesemia (HP:0002917)2.41776772
94Muscle fiber inclusion bodies (HP:0100299)2.39004477
95Conjunctival telangiectasia (HP:0000524)2.38718695
96Abnormality of potassium homeostasis (HP:0011042)2.35801847
97Abnormal atrioventricular conduction (HP:0005150)2.35490394
98Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.33875799
99Decreased circulating renin level (HP:0003351)2.33042347
100Aortic aneurysm (HP:0004942)2.32403895
101Skin nodule (HP:0200036)2.31107135
102Dilated cardiomyopathy (HP:0001644)2.30083172
103Aneurysm (HP:0002617)2.30003910
104Polyuria (HP:0000103)2.29477612
105Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29400561
106Heart block (HP:0012722)2.27463166
107Foot dorsiflexor weakness (HP:0009027)2.25141900
108Pulmonary hypertension (HP:0002092)2.24354208
109Oligomenorrhea (HP:0000876)2.24200670
110Abnormality of proline metabolism (HP:0010907)2.23941320
111Hydroxyprolinuria (HP:0003080)2.23941320
112Abnormality of the foot musculature (HP:0001436)2.23102262
113Hypotension (HP:0002615)2.22251975
114Cavernous hemangioma (HP:0001048)2.21960989
115Striae distensae (HP:0001065)2.21942093
116Hypoglycemic coma (HP:0001325)2.21708275
117Ventricular fibrillation (HP:0001663)2.21401765
118Nephrolithiasis (HP:0000787)2.15822948
119Alveolar cell carcinoma (HP:0006519)2.15506377
120Centrally nucleated skeletal muscle fibers (HP:0003687)2.14508692
121Rimmed vacuoles (HP:0003805)2.12994588
122Long toe (HP:0010511)2.12485173
123Neonatal death (HP:0003811)2.12478532
124Respiratory distress (HP:0002098)2.11761662
125Osteolytic defects of the phalanges of the hand (HP:0009771)2.10982685
126Osteolytic defects of the hand bones (HP:0009699)2.10982685
127Metabolic acidosis (HP:0001942)2.10813925
128Hypokalemia (HP:0002900)2.10383962
129Proximal amyotrophy (HP:0007126)2.10149738
130Ventricular arrhythmia (HP:0004308)2.09892671
131Nasal polyposis (HP:0100582)2.09752358
132Hypertriglyceridemia (HP:0002155)2.08941353
133Broad metatarsal (HP:0001783)2.08154856
134Joint hemorrhage (HP:0005261)2.07959504
135Hyperglycinemia (HP:0002154)2.07503193
136Tetany (HP:0001281)2.07177622
137Glucose intolerance (HP:0000833)2.06583638
138Bronchiectasis (HP:0002110)2.04060130
139Tubulointerstitial abnormality (HP:0001969)2.03616663
140Nemaline bodies (HP:0003798)2.03480286
141Dehydration (HP:0001944)2.03374120
142Mildly elevated creatine phosphokinase (HP:0008180)2.01244906
143Myocardial infarction (HP:0001658)2.00787694
144Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00060606
145Neoplasm of the tracheobronchial system (HP:0100552)1.99228017
146Delayed CNS myelination (HP:0002188)1.97890119
147Abnormal cartilage morphology (HP:0002763)1.96932324
148Hypercortisolism (HP:0001578)1.96029973
149Mitral stenosis (HP:0001718)1.95947601
150Bell-shaped thorax (HP:0001591)1.95939145
151Hyponatremia (HP:0002902)1.95732227
152Lymphangioma (HP:0100764)1.95508872
153Steppage gait (HP:0003376)1.94919685
154Cerebral palsy (HP:0100021)1.94135112
155Malnutrition (HP:0004395)1.92809656
156Calf muscle hypertrophy (HP:0008981)1.92662287
157Chondrocalcinosis (HP:0000934)1.92122289
158Axonal loss (HP:0003447)1.90951008
159Muscle hypertrophy of the lower extremities (HP:0008968)1.90869818
160Abnormality of magnesium homeostasis (HP:0004921)1.90843783
161Prolonged QT interval (HP:0001657)1.90160919
162Glycosuria (HP:0003076)1.90133692
163Abnormality of urine glucose concentration (HP:0011016)1.90133692
164Fat malabsorption (HP:0002630)1.89469183
165Portal hypertension (HP:0001409)1.87601034
166Hypoalphalipoproteinemia (HP:0003233)1.87101683
167Cerebral aneurysm (HP:0004944)1.87044943
168Shawl scrotum (HP:0000049)1.86780618
169Systemic lupus erythematosus (HP:0002725)1.86670857
170Abnormality of complement system (HP:0005339)1.86408186
171Nephritis (HP:0000123)1.85323284
172Hyperlipoproteinemia (HP:0010980)1.83868563
173Amyloidosis (HP:0011034)1.82968841
174Muscle fiber splitting (HP:0003555)1.82819806
175Bronchitis (HP:0012387)1.77488752
176Recurrent gram-negative bacterial infections (HP:0005420)1.77125324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.60935775
2TGFBR23.65143023
3WNK42.51981529
4MYLK2.49841809
5RIPK12.41096854
6FGFR42.35742068
7BCKDK2.26308959
8MAP3K32.19082661
9ERN12.10642948
10OXSR12.07689170
11EPHB12.07108346
12TTN1.95908025
13FER1.80840948
14EPHB21.78688925
15CDC42BPA1.78032899
16WNK31.77893643
17MAP3K61.72984608
18TRIB31.70610405
19NLK1.57929066
20MAPKAPK31.55243227
21GRK11.50254576
22LRRK21.50122903
23MAP3K21.46733177
24LATS21.46309544
25MAP3K131.45405820
26PTK61.43552218
27MST1R1.41878376
28MST41.41241560
29KDR1.40226089
30MAP2K31.29179879
31PDK21.26605087
32LMTK21.26267669
33PAK41.26096589
34AKT31.24970413
35FGFR21.22286363
36TGFBR11.19005684
37EEF2K1.17617540
38CSK1.15369034
39MAP3K71.11677761
40STK391.09726329
41PDGFRA1.09029440
42MAPK71.08066025
43SIK11.04536682
44PDK31.03468856
45PDK41.03468856
46LATS11.01719293
47EPHA31.01332777
48FRK1.00404104
49MAPK150.99155489
50STK38L0.98826277
51PAK30.98808773
52INSRR0.98676617
53MOS0.97191229
54MAP2K20.94416146
55MAPK40.93828235
56STK100.92682395
57GSK3A0.91192453
58FGFR30.89525179
59SGK4940.86926286
60SGK2230.86926286
61PTK20.86506574
62GRK50.86045902
63SGK30.85539350
64KIT0.84218412
65PDPK10.83670086
66ILK0.81233026
67PTK2B0.78803001
68BLK0.78310501
69MUSK0.78010184
70DMPK0.76777673
71PRKD10.76105760
72NEK90.72498465
73CAMK1D0.71924634
74DAPK20.71917113
75SGK20.71842639
76DAPK30.71537714
77MET0.69478562
78PKN20.66927879
79EPHA20.66631562
80TYK20.66432884
81JAK10.65399769
82TEC0.64003449
83STK380.62280366
84RET0.62251934
85PRKG10.60225138
86PRKCH0.59047696
87PDGFRB0.57254712
88PRPF4B0.56315931
89GRK70.55421922
90MTOR0.54684901
91CAMK10.53912795
92PINK10.51395861
93JAK20.50636107
94ROCK20.50323615
95PRKAA20.49343009
96CAMK40.46867571
97NEK10.46856652
98MARK30.46136523
99MAP2K10.45489420
100IRAK10.45023272
101STK240.44652123
102TBK10.44483075
103ARAF0.44119751
104PHKG10.43653151
105PHKG20.43653151
106PRKACG0.42736738
107ZAP700.42377366
108DDR20.41845592
109WNK10.41734935
110PRKACB0.41719245
111PIK3CG0.41568801
112PRKCE0.41231926
113PAK20.41139944
114PRKAA10.40612760
115ABL20.39641720
116RPS6KA20.39543564
117RPS6KC10.39379706
118RPS6KL10.39379706
119CDK60.39040046
120MAPK120.38927059
121ROCK10.38896035
122PIK3CA0.37471022
123CAMK1G0.37035409
124TRPM70.35594305
125OBSCN0.35584622
126IKBKE0.34910179
127MAP3K10.34882387
128EGFR0.34732068
129MAP3K140.33539537
130STK30.33011268
131MARK20.32715903
132BMX0.31903402
133TESK10.31821714
134TAOK30.30936496
135HIPK20.28640992

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41966397
2Pentose and glucuronate interconversions_Homo sapiens_hsa000402.76592402
3Tryptophan metabolism_Homo sapiens_hsa003802.71888998
4Fatty acid degradation_Homo sapiens_hsa000712.68904625
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60904579
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.50419871
7* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.49398691
8Propanoate metabolism_Homo sapiens_hsa006402.46367637
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.32150377
10Chemical carcinogenesis_Homo sapiens_hsa052042.26810100
11Butanoate metabolism_Homo sapiens_hsa006502.16758925
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04383394
13Caffeine metabolism_Homo sapiens_hsa002322.02559230
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99865604
15Nitrogen metabolism_Homo sapiens_hsa009101.98539047
16Fatty acid metabolism_Homo sapiens_hsa012121.89536331
17Peroxisome_Homo sapiens_hsa041461.86662800
18beta-Alanine metabolism_Homo sapiens_hsa004101.85564916
19PPAR signaling pathway_Homo sapiens_hsa033201.85381093
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82739979
21Complement and coagulation cascades_Homo sapiens_hsa046101.76814562
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75384269
23Sulfur metabolism_Homo sapiens_hsa009201.73291860
24Circadian rhythm_Homo sapiens_hsa047101.67709766
25Histidine metabolism_Homo sapiens_hsa003401.62376183
26Retinol metabolism_Homo sapiens_hsa008301.61481567
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.61379661
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60913563
29Arginine biosynthesis_Homo sapiens_hsa002201.57993589
30Bile secretion_Homo sapiens_hsa049761.57602600
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55404640
32Selenocompound metabolism_Homo sapiens_hsa004501.49467120
33Pyruvate metabolism_Homo sapiens_hsa006201.47753104
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46610147
35Glutathione metabolism_Homo sapiens_hsa004801.41604347
36Phenylalanine metabolism_Homo sapiens_hsa003601.37173183
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32165178
38Vitamin digestion and absorption_Homo sapiens_hsa049771.30136729
39Starch and sucrose metabolism_Homo sapiens_hsa005001.23482726
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20317185
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13059518
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05213216
43Glycerolipid metabolism_Homo sapiens_hsa005611.00189696
44Phagosome_Homo sapiens_hsa041450.99424048
45Carbon metabolism_Homo sapiens_hsa012000.97051086
46ECM-receptor interaction_Homo sapiens_hsa045120.95655153
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.93403905
48Staphylococcus aureus infection_Homo sapiens_hsa051500.92797533
49Oxytocin signaling pathway_Homo sapiens_hsa049210.92510131
50ABC transporters_Homo sapiens_hsa020100.91823753
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90904728
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.90105262
53Fatty acid elongation_Homo sapiens_hsa000620.88640299
54Tyrosine metabolism_Homo sapiens_hsa003500.86474770
55Protein digestion and absorption_Homo sapiens_hsa049740.86455027
56Platelet activation_Homo sapiens_hsa046110.84403146
57Prion diseases_Homo sapiens_hsa050200.84077784
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82675388
59Arginine and proline metabolism_Homo sapiens_hsa003300.81038303
60Dorso-ventral axis formation_Homo sapiens_hsa043200.80942371
61Arachidonic acid metabolism_Homo sapiens_hsa005900.80763229
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79984963
63Cardiac muscle contraction_Homo sapiens_hsa042600.79828685
64Insulin signaling pathway_Homo sapiens_hsa049100.79442548
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78585756
66Viral myocarditis_Homo sapiens_hsa054160.74629693
67Mineral absorption_Homo sapiens_hsa049780.71755138
68Lysine degradation_Homo sapiens_hsa003100.68550355
69Fat digestion and absorption_Homo sapiens_hsa049750.67437515
70GnRH signaling pathway_Homo sapiens_hsa049120.67410877
71Focal adhesion_Homo sapiens_hsa045100.67046284
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.66547339
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65802133
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.65505396
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.63681875
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.63087501
77Linoleic acid metabolism_Homo sapiens_hsa005910.62434318
78Insulin resistance_Homo sapiens_hsa049310.62421229
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62420858
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.61538283
81Renal cell carcinoma_Homo sapiens_hsa052110.61496913
82Renin-angiotensin system_Homo sapiens_hsa046140.58015943
83Adherens junction_Homo sapiens_hsa045200.56516642
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.56214395
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55564926
86Salivary secretion_Homo sapiens_hsa049700.55500333
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52826974
88Fatty acid biosynthesis_Homo sapiens_hsa000610.51657416
89Gap junction_Homo sapiens_hsa045400.51539509
90Choline metabolism in cancer_Homo sapiens_hsa052310.50658099
91Tight junction_Homo sapiens_hsa045300.50174684
92cAMP signaling pathway_Homo sapiens_hsa040240.49422135
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49015390
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48007135
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47146947
96Osteoclast differentiation_Homo sapiens_hsa043800.46660603
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46459021
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43756870
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43429212
100Calcium signaling pathway_Homo sapiens_hsa040200.43069247
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.41454524
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41243675
103Toxoplasmosis_Homo sapiens_hsa051450.41222017
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41177255
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40869359
106TGF-beta signaling pathway_Homo sapiens_hsa043500.40414138
107Notch signaling pathway_Homo sapiens_hsa043300.38102844
108Biosynthesis of amino acids_Homo sapiens_hsa012300.37741462
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.37550861
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37011246
111Amoebiasis_Homo sapiens_hsa051460.35270689
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35263273
113Sulfur relay system_Homo sapiens_hsa041220.35117384
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34841793
115Asthma_Homo sapiens_hsa053100.34177669
116VEGF signaling pathway_Homo sapiens_hsa043700.33442068
117Lysosome_Homo sapiens_hsa041420.32532757
118Malaria_Homo sapiens_hsa051440.31095487
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30872631
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29889428
121Thyroid hormone synthesis_Homo sapiens_hsa049180.29784353
122Pertussis_Homo sapiens_hsa051330.29365990
123Dilated cardiomyopathy_Homo sapiens_hsa054140.29223610
124Ovarian steroidogenesis_Homo sapiens_hsa049130.28150924
125Folate biosynthesis_Homo sapiens_hsa007900.27248563
126Collecting duct acid secretion_Homo sapiens_hsa049660.25957756
127Pentose phosphate pathway_Homo sapiens_hsa000300.25580231
128Gastric acid secretion_Homo sapiens_hsa049710.23022451
129Renin secretion_Homo sapiens_hsa049240.22990758
130Hepatitis C_Homo sapiens_hsa051600.21612380
131Bladder cancer_Homo sapiens_hsa052190.20798016
132Proteoglycans in cancer_Homo sapiens_hsa052050.20603932
133AMPK signaling pathway_Homo sapiens_hsa041520.19602801
134Pancreatic secretion_Homo sapiens_hsa049720.19136135
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18904791
136Small cell lung cancer_Homo sapiens_hsa052220.17953016
137Rheumatoid arthritis_Homo sapiens_hsa053230.17724013
138Rap1 signaling pathway_Homo sapiens_hsa040150.17421539
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.15816701
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.15237805

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