FMO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.67879223
2L-phenylalanine catabolic process (GO:0006559)7.67879223
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.30559792
4L-phenylalanine metabolic process (GO:0006558)7.30559792
5aromatic amino acid family catabolic process (GO:0009074)6.68782286
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.57716575
7oxidative demethylation (GO:0070989)6.33768860
8high-density lipoprotein particle remodeling (GO:0034375)5.90824375
9epoxygenase P450 pathway (GO:0019373)5.79862090
10ethanol metabolic process (GO:0006067)5.79010502
11tryptophan catabolic process (GO:0006569)5.74572815
12indole-containing compound catabolic process (GO:0042436)5.74572815
13indolalkylamine catabolic process (GO:0046218)5.74572815
14phenylpropanoid metabolic process (GO:0009698)5.71621293
15urea cycle (GO:0000050)5.68299241
16urea metabolic process (GO:0019627)5.68299241
17kynurenine metabolic process (GO:0070189)5.67416250
18drug catabolic process (GO:0042737)5.59752798
19negative regulation of fibrinolysis (GO:0051918)5.55875738
20bile acid biosynthetic process (GO:0006699)5.51498808
21tryptophan metabolic process (GO:0006568)5.46436812
22peptidyl-glutamic acid carboxylation (GO:0017187)5.31749738
23protein carboxylation (GO:0018214)5.31749738
24regulation of fibrinolysis (GO:0051917)5.25088600
25cysteine metabolic process (GO:0006534)5.24818830
26sulfur amino acid catabolic process (GO:0000098)5.23674444
27alpha-linolenic acid metabolic process (GO:0036109)5.22511230
28nitrogen cycle metabolic process (GO:0071941)5.20846593
29glyoxylate metabolic process (GO:0046487)5.16171377
30regulation of cholesterol esterification (GO:0010872)5.14694231
31protein activation cascade (GO:0072376)5.13674086
32serine family amino acid catabolic process (GO:0009071)5.09901991
33exogenous drug catabolic process (GO:0042738)5.09736893
34bile acid metabolic process (GO:0008206)5.02886843
35reverse cholesterol transport (GO:0043691)4.97458498
36S-adenosylmethionine metabolic process (GO:0046500)4.96905894
37tyrosine metabolic process (GO:0006570)4.96613098
38protein-lipid complex remodeling (GO:0034368)4.90436696
39macromolecular complex remodeling (GO:0034367)4.90436696
40plasma lipoprotein particle remodeling (GO:0034369)4.90436696
41complement activation (GO:0006956)4.90142606
42aromatic amino acid family metabolic process (GO:0009072)4.85204212
43homocysteine metabolic process (GO:0050667)4.84772188
44negative regulation of cholesterol transport (GO:0032375)4.83477797
45negative regulation of sterol transport (GO:0032372)4.83477797
46flavonoid metabolic process (GO:0009812)4.78504325
47regulation of plasminogen activation (GO:0010755)4.77593858
48complement activation, classical pathway (GO:0006958)4.75744021
49regulation of triglyceride catabolic process (GO:0010896)4.66489323
50negative regulation of protein activation cascade (GO:2000258)4.65047315
51alpha-amino acid catabolic process (GO:1901606)4.64891650
52amino-acid betaine metabolic process (GO:0006577)4.64216785
53phospholipid efflux (GO:0033700)4.60269141
54cellular glucuronidation (GO:0052695)4.60240978
55negative regulation of blood coagulation (GO:0030195)4.56781666
56negative regulation of hemostasis (GO:1900047)4.56781666
57regulation of humoral immune response (GO:0002920)4.52207697
58triglyceride homeostasis (GO:0070328)4.49332698
59acylglycerol homeostasis (GO:0055090)4.49332698
60lysine metabolic process (GO:0006553)4.48740848
61lysine catabolic process (GO:0006554)4.48740848
62cellular ketone body metabolic process (GO:0046950)4.45381114
63plasma lipoprotein particle clearance (GO:0034381)4.44965384
64* drug metabolic process (GO:0017144)4.40043682
65regulation of protein activation cascade (GO:2000257)4.39196966
66acute-phase response (GO:0006953)4.37037672
67complement activation, alternative pathway (GO:0006957)4.36588149
68bile acid and bile salt transport (GO:0015721)4.27821931
69cholesterol efflux (GO:0033344)4.26185777
70low-density lipoprotein particle remodeling (GO:0034374)4.25276984
71cellular amino acid catabolic process (GO:0009063)4.25218833
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.25042068
73glycine metabolic process (GO:0006544)4.24406669
74imidazole-containing compound metabolic process (GO:0052803)4.18516448
75benzene-containing compound metabolic process (GO:0042537)4.17709455
76opsonization (GO:0008228)4.17626497
77hormone catabolic process (GO:0042447)4.15970558
78glutamate metabolic process (GO:0006536)4.15745954
79negative regulation of wound healing (GO:0061045)4.15650436
80negative regulation of coagulation (GO:0050819)4.14703823
81negative regulation of lipase activity (GO:0060192)4.12020619
82alkaloid metabolic process (GO:0009820)4.11005500
83uronic acid metabolic process (GO:0006063)4.10660272
84glucuronate metabolic process (GO:0019585)4.10660272
85positive regulation of triglyceride lipase activity (GO:0061365)4.10410188
86negative regulation of complement activation (GO:0045916)4.10208307
87arginine metabolic process (GO:0006525)4.09101657
88indolalkylamine metabolic process (GO:0006586)4.08692888
89plasma lipoprotein particle assembly (GO:0034377)4.04072613
90cellular biogenic amine catabolic process (GO:0042402)4.01494603
91amine catabolic process (GO:0009310)4.01494603
92serine family amino acid metabolic process (GO:0009069)4.00854961
93regulation of complement activation (GO:0030449)3.99781347
94aldehyde catabolic process (GO:0046185)3.98894442
95regulation of bile acid biosynthetic process (GO:0070857)3.98223221
96cytolysis (GO:0019835)3.95318503
97coenzyme catabolic process (GO:0009109)3.95217844
98cellular modified amino acid catabolic process (GO:0042219)3.94619550
99omega-hydroxylase P450 pathway (GO:0097267)3.90923457
100serine family amino acid biosynthetic process (GO:0009070)3.90101558
101ethanol oxidation (GO:0006069)3.89172590
102short-chain fatty acid metabolic process (GO:0046459)3.85234248
103ketone body metabolic process (GO:1902224)3.84853751
104fibrinolysis (GO:0042730)3.83449164
105positive regulation of blood coagulation (GO:0030194)3.81008465
106positive regulation of hemostasis (GO:1900048)3.81008465
107positive regulation of lipid catabolic process (GO:0050996)3.80330471
108dicarboxylic acid biosynthetic process (GO:0043650)3.78462296
109cholesterol homeostasis (GO:0042632)3.76990416
110carboxylic acid catabolic process (GO:0046395)3.74850656
111organic acid catabolic process (GO:0016054)3.74850656
112blood coagulation, intrinsic pathway (GO:0007597)3.74126915
113very-low-density lipoprotein particle assembly (GO:0034379)3.71991459
114steroid catabolic process (GO:0006706)3.71095666
115disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.70646283
116killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.70646283
117sterol homeostasis (GO:0055092)3.70630398
118plasma lipoprotein particle organization (GO:0071827)3.68513854
119* xenobiotic metabolic process (GO:0006805)3.66173992
120cofactor catabolic process (GO:0051187)3.66077777
121protein-lipid complex assembly (GO:0065005)3.62832107
122positive regulation of fatty acid beta-oxidation (GO:0032000)3.62300992
123phospholipid homeostasis (GO:0055091)3.59647818
124heme transport (GO:0015886)3.58395062
125xenobiotic catabolic process (GO:0042178)3.56960212
126positive regulation of lipoprotein lipase activity (GO:0051006)3.55755056
127positive regulation of coagulation (GO:0050820)3.49581664
128primary alcohol catabolic process (GO:0034310)3.43731072
129arginine catabolic process (GO:0006527)3.41315236
130acute inflammatory response (GO:0002526)3.41143962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.39538226
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.01057550
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.71092213
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.48944951
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.26381021
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.16106313
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.98036965
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.00300126
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87390562
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10621655
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7621765
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89915903
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88539014
14CLOCK_20551151_ChIP-Seq_293T_Human1.72761096
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.59745842
16GATA1_22025678_ChIP-Seq_K562_Human1.56419497
17HTT_18923047_ChIP-ChIP_STHdh_Human1.49750947
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39445525
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37302465
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.36729770
21GBX2_23144817_ChIP-Seq_PC3_Human1.34455795
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29394390
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.25913046
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23550435
25* NFE2_27457419_Chip-Seq_LIVER_Mouse1.21946284
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20925650
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20708353
28* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17507779
29ER_23166858_ChIP-Seq_MCF-7_Human1.14491994
30* PHF8_20622853_ChIP-Seq_HELA_Human1.11368218
31* HNFA_21074721_ChIP-Seq_CACO-2_Human1.10940133
32RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09588431
33* EZH2_27294783_Chip-Seq_NPCs_Mouse1.08428221
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.06290116
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05408498
36* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04946309
37* GATA6_21074721_ChIP-Seq_CACO-2_Human1.00139885
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99772043
39* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99729019
40* NFYA_21822215_ChIP-Seq_K562_Human0.97304315
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96968039
42PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96695736
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96377658
44ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95108451
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94333977
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93979510
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92420957
48RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91501270
49TP53_18474530_ChIP-ChIP_U2OS_Human0.91193543
50* ETV1_20927104_ChIP-Seq_GIST48_Human0.90946661
51SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90015971
52* CRX_20693478_ChIP-Seq_RETINA_Mouse0.89279352
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88886452
54AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88610768
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88207280
56* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87550222
57* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86676361
58GATA4_25053715_ChIP-Seq_YYC3_Human0.85706186
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85569007
60IGF1R_20145208_ChIP-Seq_DFB_Human0.85215649
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84302391
62CBP_20019798_ChIP-Seq_JUKART_Human0.83877862
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83877862
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82313717
65SOX2_19829295_ChIP-Seq_ESCs_Human0.81290769
66NANOG_19829295_ChIP-Seq_ESCs_Human0.81290769
67KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81046719
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80869701
69CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80792980
70* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.80163810
71* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.79228028
72ZNF263_19887448_ChIP-Seq_K562_Human0.78663280
73KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78439625
74ESR2_21235772_ChIP-Seq_MCF-7_Human0.78315920
75FOXH1_21741376_ChIP-Seq_EPCs_Human0.78121184
76* NFYB_21822215_ChIP-Seq_K562_Human0.77630392
77IRF8_22096565_ChIP-ChIP_GC-B_Human0.77401306
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77228366
79MYC_19829295_ChIP-Seq_ESCs_Human0.77200268
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76847296
81* RBPJ_21746931_ChIP-Seq_IB4_Human0.76631835
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76284224
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.76284224
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76034837
85TCF4_22108803_ChIP-Seq_LS180_Human0.75968350
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75601535
87* OCT4_18555785_Chip-Seq_ESCs_Mouse0.75198741
88* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.74438884
89* SOX2_21211035_ChIP-Seq_LN229_Human0.73631726
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.73437641
91* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.73312544
92ZFP57_27257070_Chip-Seq_ESCs_Mouse0.71096598
93ERG_20517297_ChIP-Seq_VCAP_Human0.70887737
94* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.70792969
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70769704
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.70182029
97* STAT3_18555785_Chip-Seq_ESCs_Mouse0.69872262
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69607685
99RAC3_21632823_ChIP-Seq_H3396_Human0.68879515
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68191944
101* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68180342
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67713582
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66707232
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65224818
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65224818
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64886757
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64769261
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63037937
109RARB_24833708_ChIP-Seq_LIVER_Mouse0.59010028
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.58877799
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57544780
112LXR_22292898_ChIP-Seq_THP-1_Human0.57246505
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56979344
114* CEBPB_22108803_ChIP-Seq_LS180_Human0.54570556
115GATA1_19941826_ChIP-Seq_K562_Human0.53321760
116EGR1_19032775_ChIP-ChIP_M12_Human0.53015824
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.52549033
118STAT1_17558387_ChIP-Seq_HELA_Human0.51641137
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.51382398
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50648884
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.49816984
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.49641929
123AR_20517297_ChIP-Seq_VCAP_Human0.49328117
124CBP_21632823_ChIP-Seq_H3396_Human0.48882476
125MYC_19915707_ChIP-ChIP_AK7_Human0.47828258
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47236644
127P53_21459846_ChIP-Seq_SAOS-2_Human0.46834497
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46159139
129BCAT_22108803_ChIP-Seq_LS180_Human0.45337172
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.44850930
131TAF15_26573619_Chip-Seq_HEK293_Human0.44743081
132GATA2_19941826_ChIP-Seq_K562_Human0.44116458
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42469118
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.41342234
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.41276466
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.40677400
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.40614485
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38893681
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.38840322
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.38439998
141* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.38235933
142SOX2_20726797_ChIP-Seq_SW620_Human0.38067739
143MYC_27129775_Chip-Seq_CORNEA_Mouse0.38030720
144CDX2_22108803_ChIP-Seq_LS180_Human0.37987856
145LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.37777699
146GATA6_25053715_ChIP-Seq_YYC3_Human0.37593750
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36745435
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.35869568
149* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.35692337
150STAT3_1855785_ChIP-Seq_MESCs_Mouse0.35382319
151IRF1_19129219_ChIP-ChIP_H3396_Human0.34101838
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.34049456
153TAF2_19829295_ChIP-Seq_ESCs_Human0.34015731
154SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33107947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.27895810
2MP0005360_urolithiasis7.44687345
3MP0008875_abnormal_xenobiotic_pharmacok6.36772513
4MP0005085_abnormal_gallbladder_physiolo6.21172761
5MP0005365_abnormal_bile_salt5.93884995
6MP0003806_abnormal_nucleotide_metabolis3.93835318
7MP0003252_abnormal_bile_duct3.58375323
8MP0010329_abnormal_lipoprotein_level3.54918725
9MP0009840_abnormal_foam_cell3.36827545
10MP0005083_abnormal_biliary_tract3.14801505
11MP0003195_calcinosis2.95094535
12MP0005332_abnormal_amino_acid2.81296397
13MP0001666_abnormal_nutrient_absorption2.42662420
14MP0004019_abnormal_vitamin_homeostasis2.24427111
15MP0000609_abnormal_liver_physiology2.10991846
16MP0003191_abnormal_cellular_cholesterol2.09586515
17MP0002118_abnormal_lipid_homeostasis2.06818672
18MP0002138_abnormal_hepatobiliary_system2.01039807
19MP0005451_abnormal_body_composition1.85060957
20MP0005319_abnormal_enzyme/_coenzyme1.81066896
21MP0003868_abnormal_feces_composition1.77734651
22MP0001764_abnormal_homeostasis1.67408994
23MP0005584_abnormal_enzyme/coenzyme_acti1.56471521
24MP0009697_abnormal_copulation1.55152113
25MP0003186_abnormal_redox_activity1.27039704
26MP0009643_abnormal_urine_homeostasis1.25198123
27MP0003656_abnormal_erythrocyte_physiolo1.23575472
28MP0003011_delayed_dark_adaptation1.18494652
29MP0000598_abnormal_liver_morphology1.15839274
30MP0009764_decreased_sensitivity_to1.15127631
31MP0000604_amyloidosis1.13204332
32MP0003705_abnormal_hypodermis_morpholog1.10762206
33MP0010368_abnormal_lymphatic_system1.03938338
34MP0005670_abnormal_white_adipose1.03406249
35MP0009763_increased_sensitivity_to1.01457321
36MP0002254_reproductive_system_inflammat0.97067106
37MP0005647_abnormal_sex_gland0.92606957
38MP0005408_hypopigmentation0.88396629
39MP0005636_abnormal_mineral_homeostasis0.86771746
40MP0009642_abnormal_blood_homeostasis0.86572539
41MP0004782_abnormal_surfactant_physiolog0.85671374
42MP0009765_abnormal_xenobiotic_induced0.85339664
43MP0008469_abnormal_protein_level0.84162866
44MP0002282_abnormal_trachea_morphology0.82552270
45MP0005376_homeostasis/metabolism_phenot0.79588648
46MP0002078_abnormal_glucose_homeostasis0.76649534
47MP0006036_abnormal_mitochondrial_physio0.75179464
48MP0003329_amyloid_beta_deposits0.74091335
49MP0002971_abnormal_brown_adipose0.73314910
50MP0005084_abnormal_gallbladder_morpholo0.72962188
51MP0003690_abnormal_glial_cell0.72944673
52MP0008872_abnormal_physiological_respon0.71685655
53MP0009053_abnormal_anal_canal0.70428611
54MP0001661_extended_life_span0.69447304
55MP0008874_decreased_physiological_sensi0.69133044
56MP0002876_abnormal_thyroid_physiology0.68197979
57MP0004130_abnormal_muscle_cell0.66540585
58MP0003879_abnormal_hair_cell0.65562431
59MP0005334_abnormal_fat_pad0.65163124
60MP0005535_abnormal_body_temperature0.65017335
61MP0001756_abnormal_urination0.64860499
62MP0000639_abnormal_adrenal_gland0.63662054
63MP0001915_intracranial_hemorrhage0.63261941
64MP0005266_abnormal_metabolism0.61724497
65MP0005220_abnormal_exocrine_pancreas0.58179638
66MP0005464_abnormal_platelet_physiology0.57308381
67MP0003638_abnormal_response/metabolism_0.54601161
68MP0005448_abnormal_energy_balance0.54430170
69MP0008873_increased_physiological_sensi0.52708203
70MP0002822_catalepsy0.51422541
71MP0009785_altered_susceptibility_to0.50597675
72MP0005248_abnormal_Harderian_gland0.49463917
73MP0002136_abnormal_kidney_physiology0.48414292
74MP0005395_other_phenotype0.46985018
75MP0003075_altered_response_to0.46607585
76MP0002837_dystrophic_cardiac_calcinosis0.44709956
77MP0002249_abnormal_larynx_morphology0.44584454
78MP0010386_abnormal_urinary_bladder0.43157881
79MP0004043_abnormal_pH_regulation0.42415973
80MP0003718_maternal_effect0.41991255
81MP0003436_decreased_susceptibility_to0.41900259
82MP0005167_abnormal_blood-brain_barrier0.41368876
83MP0000249_abnormal_blood_vessel0.40652514
84MP0003953_abnormal_hormone_level0.40074943
85MP0005666_abnormal_adipose_tissue0.39621977
86MP0001986_abnormal_taste_sensitivity0.39358560
87MP0006035_abnormal_mitochondrial_morpho0.38545545
88MP0004883_abnormal_blood_vessel0.38486430
89MP0009672_abnormal_birth_weight0.38189414
90MP0005551_abnormal_eye_electrophysiolog0.37963695
91MP0002090_abnormal_vision0.35925634
92MP0002928_abnormal_bile_duct0.34989508
93MP0003724_increased_susceptibility_to0.34951237
94MP0002332_abnormal_exercise_endurance0.34418358
95MP0002168_other_aberrant_phenotype0.34300946
96MP0001243_abnormal_dermal_layer0.33965461
97MP0009115_abnormal_fat_cell0.33032617
98MP0004142_abnormal_muscle_tone0.32920132
99MP0000230_abnormal_systemic_arterial0.32884236
100MP0005023_abnormal_wound_healing0.30547536
101MP0001853_heart_inflammation0.28652136
102MP0005164_abnormal_response_to0.28184008
103MP0006082_CNS_inflammation0.27854457
104MP0005187_abnormal_penis_morphology0.27854402
105MP0002132_abnormal_respiratory_system0.27128208
106MP0002970_abnormal_white_adipose0.26820784
107MP0001881_abnormal_mammary_gland0.25616195
108MP0001845_abnormal_inflammatory_respons0.25241185
109MP0005166_decreased_susceptibility_to0.24850272
110MP0003959_abnormal_lean_body0.23465227
111MP0005595_abnormal_vascular_smooth0.23219897
112MP0000467_abnormal_esophagus_morphology0.22286830
113MP0001984_abnormal_olfaction0.21305983
114MP0002135_abnormal_kidney_morphology0.21084179
115MP0002269_muscular_atrophy0.20572651
116MP0003633_abnormal_nervous_system0.19691889
117MP0001440_abnormal_grooming_behavior0.19518784
118MP0000566_synostosis0.18490946
119MP0001944_abnormal_pancreas_morphology0.17861277
120MP0002295_abnormal_pulmonary_circulatio0.16563018
121MP0005646_abnormal_pituitary_gland0.16434366

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.80134177
2Deep venous thrombosis (HP:0002625)7.78914340
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.97704818
4Intrahepatic cholestasis (HP:0001406)6.78389537
5Hypobetalipoproteinemia (HP:0003563)6.65807271
6Prolonged partial thromboplastin time (HP:0003645)6.56538488
7Xanthomatosis (HP:0000991)6.33169835
8Hyperlipoproteinemia (HP:0010980)6.12029016
9Joint hemorrhage (HP:0005261)4.95537067
10Hypolipoproteinemia (HP:0010981)4.93200828
11Hyperammonemia (HP:0001987)4.75680825
12Abnormality of methionine metabolism (HP:0010901)4.70595677
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.56410219
14Epidermoid cyst (HP:0200040)4.43378542
15Recurrent gram-negative bacterial infections (HP:0005420)4.42984124
16Abnormality of sulfur amino acid metabolism (HP:0004339)4.42952206
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.41967630
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.41210617
19Ketosis (HP:0001946)4.38723531
20Hypoalphalipoproteinemia (HP:0003233)4.32816832
21Abnormality of the common coagulation pathway (HP:0010990)4.27294264
22Hyperglycinemia (HP:0002154)4.18960579
23Abnormality of pyrimidine metabolism (HP:0004353)4.17823078
24Hyperglycinuria (HP:0003108)3.99452203
25Abnormality of glycine metabolism (HP:0010895)3.93538138
26Abnormality of serine family amino acid metabolism (HP:0010894)3.93538138
27Hypercholesterolemia (HP:0003124)3.91084762
28Complement deficiency (HP:0004431)3.87540360
29Hypoglycemic coma (HP:0001325)3.76606241
30Fat malabsorption (HP:0002630)3.68152243
31Abnormality of the intrinsic pathway (HP:0010989)3.67942768
32Conjugated hyperbilirubinemia (HP:0002908)3.51377220
33Hyperbilirubinemia (HP:0002904)3.42018170
34Abnormality of fatty-acid metabolism (HP:0004359)3.28747011
35Delayed CNS myelination (HP:0002188)3.28334163
36Abnormality of nucleobase metabolism (HP:0010932)3.25788179
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.24250806
38Abnormality of serum amino acid levels (HP:0003112)3.06946396
39Ketoacidosis (HP:0001993)3.03495483
40Fair hair (HP:0002286)2.99513058
41Hepatocellular carcinoma (HP:0001402)2.98135777
42Reduced antithrombin III activity (HP:0001976)2.94574125
43Metabolic acidosis (HP:0001942)2.86174992
44Myocardial infarction (HP:0001658)2.85866105
45Vascular calcification (HP:0004934)2.84717612
46Osteomalacia (HP:0002749)2.82334099
47Abnormality of complement system (HP:0005339)2.80151670
48Abnormality of purine metabolism (HP:0004352)2.79770729
49Skin nodule (HP:0200036)2.76496586
50Spontaneous abortion (HP:0005268)2.73502744
51Steatorrhea (HP:0002570)2.72718001
52Glomerulonephritis (HP:0000099)2.69213963
53Lethargy (HP:0001254)2.68531219
54Spastic diplegia (HP:0001264)2.62455197
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60593483
56Dicarboxylic aciduria (HP:0003215)2.60593483
57Gout (HP:0001997)2.57092517
58Cerebral edema (HP:0002181)2.54571048
59Cardiovascular calcification (HP:0011915)2.54043300
60Mitral stenosis (HP:0001718)2.50744776
61Neonatal hypoglycemia (HP:0001998)2.49574394
62Hypochromic microcytic anemia (HP:0004840)2.45676672
63Irritability (HP:0000737)2.45173352
64Abnormal gallbladder morphology (HP:0012437)2.37837634
65Menorrhagia (HP:0000132)2.35887254
66Bile duct proliferation (HP:0001408)2.34024649
67Abnormal biliary tract physiology (HP:0012439)2.34024649
68Esophageal varix (HP:0002040)2.33645600
69Hypoglycemic seizures (HP:0002173)2.33366306
70Cholelithiasis (HP:0001081)2.30328892
71Acanthocytosis (HP:0001927)2.30112887
72Malnutrition (HP:0004395)2.28710814
73Neonatal onset (HP:0003623)2.26044368
74Amyloidosis (HP:0011034)2.22478987
75Purpura (HP:0000979)2.21965036
76Arthropathy (HP:0003040)2.21946493
77Hyperphosphaturia (HP:0003109)2.21842360
78Alkalosis (HP:0001948)2.17688776
79Abnormality of urine glucose concentration (HP:0011016)2.16688563
80Glycosuria (HP:0003076)2.16688563
81Vomiting (HP:0002013)2.12794823
82Generalized hypopigmentation of hair (HP:0011358)2.11188907
83Enlarged kidneys (HP:0000105)2.09416767
84Brushfield spots (HP:0001088)2.08788020
85Late onset (HP:0003584)2.08414522
86Gingival bleeding (HP:0000225)2.06654620
87Generalized aminoaciduria (HP:0002909)2.05421829
88Hydroxyprolinuria (HP:0003080)2.04612100
89Abnormality of proline metabolism (HP:0010907)2.04612100
90Pancreatitis (HP:0001733)2.04478277
91Thrombophlebitis (HP:0004418)2.04225568
92Poikilocytosis (HP:0004447)2.01704862
93Opisthotonus (HP:0002179)1.98326627
94Systemic lupus erythematosus (HP:0002725)1.97979165
95Abnormal gallbladder physiology (HP:0012438)1.95938189
96Cholecystitis (HP:0001082)1.95938189
97Nephritis (HP:0000123)1.94057730
98Hemorrhage of the eye (HP:0011885)1.92129304
99Hypophosphatemic rickets (HP:0004912)1.90118332
100Sensorimotor neuropathy (HP:0007141)1.88092034
101Hyperinsulinemic hypoglycemia (HP:0000825)1.87415252
102Abnormal cartilage morphology (HP:0002763)1.86792443
103Abnormality of the gallbladder (HP:0005264)1.86228635
104Abnormality of iron homeostasis (HP:0011031)1.85654810
105Status epilepticus (HP:0002133)1.85481463
106Gangrene (HP:0100758)1.84167858
107Rickets (HP:0002748)1.83619229
108Abnormality of transition element cation homeostasis (HP:0011030)1.83056043
109Elevated alkaline phosphatase (HP:0003155)1.81445291
110Reticulocytosis (HP:0001923)1.78998189
111Pulmonary embolism (HP:0002204)1.78962433
112Renal cortical cysts (HP:0000803)1.77012490
113Increased serum ferritin (HP:0003281)1.76537664
114Abnormality of vitamin metabolism (HP:0100508)1.76508420
115Stroke (HP:0001297)1.74933161
116Cerebral palsy (HP:0100021)1.74743944
117Abnormal enzyme/coenzyme activity (HP:0012379)1.73146639
118Abnormal urine phosphate concentration (HP:0012599)1.68740022
119Abnormality of alkaline phosphatase activity (HP:0004379)1.67745251
120Atrioventricular block (HP:0001678)1.67253848
121Blue irides (HP:0000635)1.66034590
122Potter facies (HP:0002009)1.62739980
123Facial shape deformation (HP:0011334)1.62739980
124Joint swelling (HP:0001386)1.61424461
125Retinal atrophy (HP:0001105)1.60281107
126Chronic hepatic failure (HP:0100626)1.52751935
127Abnormality of the Achilles tendon (HP:0005109)1.52048587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.25982224
2SIK14.61726660
3FGFR44.34702731
4ERN13.62082248
5PKN23.37906893
6INSRR2.91360506
7TAOK32.73987417
8MAP4K22.57627734
9MAP2K42.42649748
10FLT32.32274757
11WNK32.28834941
12TRIB32.11883236
13ADRBK22.11782065
14MST1R2.08795664
15DAPK22.05547276
16PIK3CG1.85601804
17MYLK1.81360868
18ERBB41.76422923
19TYK21.69860016
20LATS11.55539191
21PTK61.54122424
22FGFR21.51255217
23ABL21.49604485
24TXK1.48025977
25KDR1.46092377
26NTRK31.41370891
27ACVR1B1.39133750
28BMPR1B1.35453033
29MAPK111.34643070
30WNK41.32970146
31TIE11.30616986
32KIT1.29323466
33FRK1.28073492
34NLK1.26838147
35CAMKK21.21352878
36MAP2K31.20201865
37PINK11.17974641
38JAK21.15727698
39PDK21.15085760
40PRKG11.14918686
41PRKACA1.13318322
42PRKAA21.11822656
43TNK21.07671246
44MAP3K71.07372855
45GRK61.07024878
46NEK91.06964966
47MAPKAPK31.05720609
48MUSK1.03922587
49MAPK41.03572752
50FER1.02989225
51MAP2K21.00714040
52TBK10.99716530
53MAP3K140.99105965
54MAP3K30.98565424
55TLK10.96755947
56TGFBR20.95357484
57PRKCZ0.95225628
58CSK0.94688104
59JAK10.93754060
60NUAK10.91901477
61MAPK120.89289677
62EPHB10.86559154
63EPHA40.86127603
64MAP2K60.84584678
65MET0.83688758
66MAP3K110.82479328
67PRKCE0.78807169
68PRKACG0.77328692
69CDK60.76191187
70CSNK1D0.75584292
71MAP3K100.75412761
72RIPK10.75330984
73DYRK1B0.75240336
74SGK30.73538045
75STK38L0.71650804
76ERBB20.71364604
77ADRBK10.68934059
78OBSCN0.66542334
79GRK70.65996326
80SGK10.65571890
81RET0.63374416
82GSK3A0.63055908
83PRKACB0.62494615
84PTK20.62315442
85GRK10.61950104
86OXSR10.61834855
87MAPK70.61369193
88MAP3K40.60493754
89TAOK20.58823794
90MAP3K120.58526798
91CAMK1D0.58481996
92MAPK130.57334332
93TRPM70.56792606
94RPS6KA30.56763287
95PDPK10.56250232
96PRKAA10.55321732
97CSF1R0.54950350
98PRKCB0.54763779
99SGK20.54546554
100ZAK0.54258293
101CAMK2G0.53994482
102PRKCQ0.53863126
103EPHA30.53697801
104FGFR30.53607423
105STK160.52043225
106CASK0.51802476
107IKBKE0.51693241
108CSNK1A10.51649278
109IGF1R0.50565906
110EIF2AK30.49876451
111DYRK20.48666088
112CSNK1G10.48143778
113STK390.46977501
114MAP3K60.46271538
115IKBKB0.45421874
116MAP3K130.44339348
117MAP2K10.44202149
118MAPK150.43491058
119MAP3K50.42995406
120PHKG20.42401497
121PHKG10.42401497
122BCR0.42034905
123STK110.41882413
124SGK2230.41782089
125SGK4940.41782089
126PRKCG0.40843524
127PDK10.40544986
128LATS20.36263929
129CSNK1G20.35935486
130MAP3K20.35583481
131PIK3CA0.35520220
132CAMKK10.33276182
133PDK30.32066818
134PDK40.32066818
135PRKCA0.31796063
136EGFR0.29034810
137CAMK40.28915840
138PBK0.27837361
139CSNK1G30.27685738
140MTOR0.27049519
141EPHB20.26604659
142AKT30.26388909
143CDK40.26342122
144FGFR10.25042727
145MAP3K10.24419333
146ICK0.23880863
147PAK30.22583509
148ITK0.21679151

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.03615248
2Nitrogen metabolism_Homo sapiens_hsa009103.72530769
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.71570612
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46898049
5Arginine biosynthesis_Homo sapiens_hsa002203.07985008
6Tryptophan metabolism_Homo sapiens_hsa003802.74043828
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73862225
8Caffeine metabolism_Homo sapiens_hsa002322.69020549
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.50204572
10Complement and coagulation cascades_Homo sapiens_hsa046102.44100179
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40981631
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38228568
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.38038501
14* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37918248
15Chemical carcinogenesis_Homo sapiens_hsa052042.37261382
16Fatty acid degradation_Homo sapiens_hsa000712.35207543
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.33706581
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26575055
19Butanoate metabolism_Homo sapiens_hsa006502.04476126
20Retinol metabolism_Homo sapiens_hsa008301.96788952
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.94409927
22Peroxisome_Homo sapiens_hsa041461.89385257
23Histidine metabolism_Homo sapiens_hsa003401.88874077
24Propanoate metabolism_Homo sapiens_hsa006401.84661256
25PPAR signaling pathway_Homo sapiens_hsa033201.76938236
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75879541
27beta-Alanine metabolism_Homo sapiens_hsa004101.72112542
28Staphylococcus aureus infection_Homo sapiens_hsa051501.67418504
29Fatty acid metabolism_Homo sapiens_hsa012121.64782856
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63052231
31Phenylalanine metabolism_Homo sapiens_hsa003601.62074342
32Selenocompound metabolism_Homo sapiens_hsa004501.61096460
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53577143
34Bile secretion_Homo sapiens_hsa049761.53283470
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50950013
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46111550
37Tyrosine metabolism_Homo sapiens_hsa003501.35360164
38Sulfur metabolism_Homo sapiens_hsa009201.33974034
39Starch and sucrose metabolism_Homo sapiens_hsa005001.31119157
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.30256035
41Pyruvate metabolism_Homo sapiens_hsa006201.26128720
42Fatty acid elongation_Homo sapiens_hsa000621.22154956
43Biosynthesis of amino acids_Homo sapiens_hsa012301.19833056
44ABC transporters_Homo sapiens_hsa020101.15672947
45Steroid biosynthesis_Homo sapiens_hsa001001.13474130
46Folate biosynthesis_Homo sapiens_hsa007901.08054814
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05440242
48Carbon metabolism_Homo sapiens_hsa012001.04867852
49Fat digestion and absorption_Homo sapiens_hsa049751.03296093
50Arginine and proline metabolism_Homo sapiens_hsa003301.00185829
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.90797847
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90778893
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83169621
54Sulfur relay system_Homo sapiens_hsa041220.81868313
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.81699539
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77033992
57Lysine degradation_Homo sapiens_hsa003100.76546781
58Vitamin digestion and absorption_Homo sapiens_hsa049770.76413497
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67483245
60Glycerolipid metabolism_Homo sapiens_hsa005610.66393463
61One carbon pool by folate_Homo sapiens_hsa006700.65368352
62Glutathione metabolism_Homo sapiens_hsa004800.61988858
63Pentose phosphate pathway_Homo sapiens_hsa000300.53846042
64Vitamin B6 metabolism_Homo sapiens_hsa007500.49657960
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47967548
66Metabolic pathways_Homo sapiens_hsa011000.43313392
67Fatty acid biosynthesis_Homo sapiens_hsa000610.43051075
68Linoleic acid metabolism_Homo sapiens_hsa005910.41385916
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25836370
70Insulin resistance_Homo sapiens_hsa049310.20730002
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.19697009
72Fructose and mannose metabolism_Homo sapiens_hsa000510.19020115
73Galactose metabolism_Homo sapiens_hsa000520.18424700
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17289460
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16308344
76Systemic lupus erythematosus_Homo sapiens_hsa053220.11668955
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.11050153
78Serotonergic synapse_Homo sapiens_hsa047260.08487777
79Glucagon signaling pathway_Homo sapiens_hsa049220.07840401
80Ovarian steroidogenesis_Homo sapiens_hsa049130.04404771
81AMPK signaling pathway_Homo sapiens_hsa041520.01421802
82Mineral absorption_Homo sapiens_hsa049780.00744508
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2680053
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2652871
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2589221
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2492063
87Pertussis_Homo sapiens_hsa05133-0.2428602
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.2368172
89Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2362335
90Hepatitis C_Homo sapiens_hsa05160-0.2310773
91Type II diabetes mellitus_Homo sapiens_hsa04930-0.2274255
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.2250781
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2031367
94Regulation of autophagy_Homo sapiens_hsa04140-0.2009248
95Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1970642
96Sphingolipid metabolism_Homo sapiens_hsa00600-0.1858629
97Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1796159
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1734771
99Renin-angiotensin system_Homo sapiens_hsa04614-0.1684855
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1661407
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1647181
102Other glycan degradation_Homo sapiens_hsa00511-0.1612726
103African trypanosomiasis_Homo sapiens_hsa05143-0.1577038
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1550922
105Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1507582
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1306068
107Insulin signaling pathway_Homo sapiens_hsa04910-0.1229046
108Circadian rhythm_Homo sapiens_hsa04710-0.1214856
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1075034
110Amoebiasis_Homo sapiens_hsa05146-0.1037608
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0615007
112Prion diseases_Homo sapiens_hsa05020-0.0348918

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