FMO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.08261656
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.08261656
3epoxygenase P450 pathway (GO:0019373)6.88907082
4L-phenylalanine metabolic process (GO:0006558)6.80237723
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.80237723
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.58622274
7aromatic amino acid family catabolic process (GO:0009074)6.29950797
8omega-hydroxylase P450 pathway (GO:0097267)6.11025561
9indole-containing compound catabolic process (GO:0042436)5.60230787
10indolalkylamine catabolic process (GO:0046218)5.60230787
11tryptophan catabolic process (GO:0006569)5.60230787
12high-density lipoprotein particle remodeling (GO:0034375)5.53398814
13alpha-linolenic acid metabolic process (GO:0036109)5.46422169
14glyoxylate metabolic process (GO:0046487)5.44325054
15kynurenine metabolic process (GO:0070189)5.43195359
16urea metabolic process (GO:0019627)5.40664255
17urea cycle (GO:0000050)5.40664255
18cysteine metabolic process (GO:0006534)5.37339945
19tryptophan metabolic process (GO:0006568)5.31435108
20regulation of cholesterol esterification (GO:0010872)5.24852541
21bile acid biosynthetic process (GO:0006699)5.23233023
22sulfur amino acid catabolic process (GO:0000098)4.99861057
23phospholipid efflux (GO:0033700)4.96953065
24nitrogen cycle metabolic process (GO:0071941)4.96409628
25reverse cholesterol transport (GO:0043691)4.95471021
26lysine metabolic process (GO:0006553)4.91653309
27lysine catabolic process (GO:0006554)4.91653309
28regulation of triglyceride catabolic process (GO:0010896)4.89464045
29negative regulation of fibrinolysis (GO:0051918)4.89305651
30negative regulation of cholesterol transport (GO:0032375)4.88953959
31negative regulation of sterol transport (GO:0032372)4.88953959
32serine family amino acid catabolic process (GO:0009071)4.88931707
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81748327
34protein-lipid complex remodeling (GO:0034368)4.79275334
35macromolecular complex remodeling (GO:0034367)4.79275334
36plasma lipoprotein particle remodeling (GO:0034369)4.79275334
37peptidyl-glutamic acid carboxylation (GO:0017187)4.76211632
38protein carboxylation (GO:0018214)4.76211632
39homocysteine metabolic process (GO:0050667)4.73190754
40bile acid metabolic process (GO:0008206)4.71369770
41regulation of fibrinolysis (GO:0051917)4.65440079
42amino-acid betaine metabolic process (GO:0006577)4.63289320
43aromatic amino acid family metabolic process (GO:0009072)4.58148087
44intestinal cholesterol absorption (GO:0030299)4.56597707
45ethanol metabolic process (GO:0006067)4.54814431
46triglyceride homeostasis (GO:0070328)4.52867208
47acylglycerol homeostasis (GO:0055090)4.52867208
48cholesterol efflux (GO:0033344)4.49670033
49fibrinolysis (GO:0042730)4.49107097
50cellular ketone body metabolic process (GO:0046950)4.46564855
51plasma lipoprotein particle assembly (GO:0034377)4.39637259
52tyrosine metabolic process (GO:0006570)4.36465421
53alpha-amino acid catabolic process (GO:1901606)4.36096667
54bile acid and bile salt transport (GO:0015721)4.34443801
55regulation of protein activation cascade (GO:2000257)4.33774460
56plasma lipoprotein particle clearance (GO:0034381)4.33418539
57complement activation, alternative pathway (GO:0006957)4.21483818
58oxidative demethylation (GO:0070989)4.21195828
59drug transmembrane transport (GO:0006855)4.15386265
60glutamate metabolic process (GO:0006536)4.14151641
61positive regulation of lipoprotein lipase activity (GO:0051006)4.10714042
62positive regulation of triglyceride lipase activity (GO:0061365)4.10714042
63cellular amino acid catabolic process (GO:0009063)4.05960999
64cellular glucuronidation (GO:0052695)4.05540780
65very-low-density lipoprotein particle assembly (GO:0034379)4.04655930
66urate metabolic process (GO:0046415)4.04188835
67serine family amino acid metabolic process (GO:0009069)4.01147940
68flavonoid metabolic process (GO:0009812)4.00971653
69short-chain fatty acid metabolic process (GO:0046459)4.00545441
70protein-lipid complex assembly (GO:0065005)4.00494444
71indolalkylamine metabolic process (GO:0006586)3.99254899
72regulation of bile acid biosynthetic process (GO:0070857)3.99105579
73regulation of complement activation (GO:0030449)3.98418605
74cellular modified amino acid catabolic process (GO:0042219)3.96757663
75benzene-containing compound metabolic process (GO:0042537)3.95084489
76cholesterol homeostasis (GO:0042632)3.94939530
77fat-soluble vitamin biosynthetic process (GO:0042362)3.93593297
78phenylpropanoid metabolic process (GO:0009698)3.93077991
79S-adenosylmethionine metabolic process (GO:0046500)3.91919682
80glycine metabolic process (GO:0006544)3.91356330
81sterol homeostasis (GO:0055092)3.90999413
82regulation of cholesterol homeostasis (GO:2000188)3.89669581
83lipoprotein metabolic process (GO:0042157)3.89399366
84ketone body metabolic process (GO:1902224)3.85837196
85intestinal absorption (GO:0050892)3.84850478
86exogenous drug catabolic process (GO:0042738)3.84691545
87* drug catabolic process (GO:0042737)3.84691545
88ethanol oxidation (GO:0006069)3.84492952
89amine catabolic process (GO:0009310)3.83735159
90cellular biogenic amine catabolic process (GO:0042402)3.83735159
91phospholipid homeostasis (GO:0055091)3.83379566
92hormone catabolic process (GO:0042447)3.83202193
93serine family amino acid biosynthetic process (GO:0009070)3.81733435
94positive regulation of lipid catabolic process (GO:0050996)3.81417375
95low-density lipoprotein particle remodeling (GO:0034374)3.81309911
96arginine metabolic process (GO:0006525)3.78752441
97complement activation (GO:0006956)3.77830413
98blood coagulation, intrinsic pathway (GO:0007597)3.75964519
99protein activation cascade (GO:0072376)3.74633637
100coenzyme catabolic process (GO:0009109)3.74404746
101plasma lipoprotein particle organization (GO:0071827)3.73064917
102imidazole-containing compound metabolic process (GO:0052803)3.72362444
103positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.71627864
104dicarboxylic acid biosynthetic process (GO:0043650)3.70865546
105negative regulation of hemostasis (GO:1900047)3.67362902
106negative regulation of blood coagulation (GO:0030195)3.67362902
107negative regulation of protein activation cascade (GO:2000258)3.66453831
108glucuronate metabolic process (GO:0019585)3.65326064
109uronic acid metabolic process (GO:0006063)3.65326064
110organic acid catabolic process (GO:0016054)3.64594921
111carboxylic acid catabolic process (GO:0046395)3.64594921
112xenobiotic catabolic process (GO:0042178)3.61731794
113aldehyde catabolic process (GO:0046185)3.61399212
114complement activation, classical pathway (GO:0006958)3.61086007
115* drug metabolic process (GO:0017144)3.58261191
116primary alcohol catabolic process (GO:0034310)3.57888207
117acetyl-CoA metabolic process (GO:0006084)3.57464218
118aspartate family amino acid catabolic process (GO:0009068)3.56768047
119drug transport (GO:0015893)3.56482903
120regulation of humoral immune response (GO:0002920)3.50459708
121heme transport (GO:0015886)3.49900856
122acute-phase response (GO:0006953)3.47452920
123negative regulation of coagulation (GO:0050819)3.45697911
124negative regulation of wound healing (GO:0061045)3.33730688
125negative regulation of complement activation (GO:0045916)3.32260693
126alkaloid metabolic process (GO:0009820)3.31726023
127positive regulation of fatty acid biosynthetic process (GO:0045723)3.15506382
128L-ascorbic acid metabolic process (GO:0019852)3.14622292
129xenobiotic metabolic process (GO:0006805)3.06817744
130positive regulation of blood coagulation (GO:0030194)3.05928123
131positive regulation of hemostasis (GO:1900048)3.05928123
132glycosphingolipid catabolic process (GO:0046479)3.05825882
133regulation of plasminogen activation (GO:0010755)3.05819460
134positive regulation of coagulation (GO:0050820)3.05310045
135negative regulation of lipase activity (GO:0060192)3.01501148
136glutamine family amino acid biosynthetic process (GO:0009084)2.96467586
137regulation of sterol transport (GO:0032371)2.96113911
138regulation of cholesterol transport (GO:0032374)2.96113911
139negative regulation of humoral immune response (GO:0002921)2.91852076
140proline metabolic process (GO:0006560)2.89520198
141primary alcohol metabolic process (GO:0034308)2.89149266
142monocarboxylic acid catabolic process (GO:0072329)2.89026521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.09449325
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.97281146
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.41865149
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.39620842
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.80104306
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.73250905
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.63900518
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.88042034
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.69208540
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.83773268
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.35052884
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2359775
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99577534
14BP1_19119308_ChIP-ChIP_Hs578T_Human1.98967591
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96370823
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95709274
17IRF8_27001747_Chip-Seq_BMDM_Mouse1.87737742
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79827898
19CLOCK_20551151_ChIP-Seq_293T_Human1.74798974
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.73419911
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69408447
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63244791
23HNF4A_19822575_ChIP-Seq_HepG2_Human1.58381167
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57934302
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.51134887
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43862340
27GATA1_22025678_ChIP-Seq_K562_Human1.41047823
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40344732
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39542710
30HTT_18923047_ChIP-ChIP_STHdh_Human1.36672264
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28622128
32VDR_24787735_ChIP-Seq_THP-1_Human1.27249678
33GATA4_25053715_ChIP-Seq_YYC3_Human1.27231200
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27121770
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21518896
36SPI1_23547873_ChIP-Seq_NB4_Human1.20443848
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20132649
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19254681
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17803437
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.14990441
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.11139517
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09100700
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05175425
44RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04997250
45* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03132429
46HNFA_21074721_ChIP-Seq_CACO-2_Human1.02857905
47* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02837763
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01973029
49GATA2_21666600_ChIP-Seq_HMVEC_Human0.99486603
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98130499
51KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97463766
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97143309
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96503236
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95621551
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94995024
56AR_21909140_ChIP-Seq_LNCAP_Human0.94749487
57STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93396896
58* GATA6_21074721_ChIP-Seq_CACO-2_Human0.92952993
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92871580
60ESR2_21235772_ChIP-Seq_MCF-7_Human0.91298700
61NFE2_27457419_Chip-Seq_LIVER_Mouse0.90438193
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90394358
63* PHF8_20622853_ChIP-Seq_HELA_Human0.89391723
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88953285
65TFEB_21752829_ChIP-Seq_HELA_Human0.88041570
66SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87968001
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86918062
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86735011
69GATA3_26560356_Chip-Seq_TH2_Human0.86053084
70ESR1_21235772_ChIP-Seq_MCF-7_Human0.84041343
71* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83728424
72GATA6_25053715_ChIP-Seq_YYC3_Human0.83379455
73AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82333975
74RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82028881
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81574605
76MYB_26560356_Chip-Seq_TH2_Human0.79901065
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78104006
78* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77396994
79* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77031773
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76857529
81IRF8_22096565_ChIP-ChIP_GC-B_Human0.76122746
82* EZH2_27294783_Chip-Seq_NPCs_Mouse0.76082055
83PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76078556
84ZNF263_19887448_ChIP-Seq_K562_Human0.74327469
85* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74136543
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73887334
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73829057
88MYB_26560356_Chip-Seq_TH1_Human0.72708805
89STAT1_20625510_ChIP-Seq_HELA_Human0.72208481
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72167699
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71958977
92RARA_24833708_ChIP-Seq_LIVER_Mouse0.71128826
93CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69953028
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69670275
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69625170
96* CRX_20693478_ChIP-Seq_RETINA_Mouse0.69417497
97SOX2_20726797_ChIP-Seq_SW620_Human0.69350849
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68303388
99NFYA_21822215_ChIP-Seq_K562_Human0.68238226
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67966154
101FOXA1_25552417_ChIP-Seq_VCAP_Human0.67718337
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67014392
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67014392
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66173262
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.65813949
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.63123004
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62835904
108* STAT1_17558387_ChIP-Seq_HELA_Human0.62768657
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61084135
110CEBPB_22108803_ChIP-Seq_LS180_Human0.60967112
111* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59863406
112GATA2_19941826_ChIP-Seq_K562_Human0.59740152
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58945885
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57380565
115* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57192652
116ESET_19884257_ChIP-Seq_ESCs_Mouse0.57129107
117CDX2_22108803_ChIP-Seq_LS180_Human0.56897257
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.56151867
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56012370
120GATA1_19941826_ChIP-Seq_K562_Human0.55610516
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.54785938
122AR_20517297_ChIP-Seq_VCAP_Human0.54691766
123MYC_19915707_ChIP-ChIP_AK7_Human0.54003802
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53698915
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.53683542
126EGR1_19032775_ChIP-ChIP_M12_Human0.53136851
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.52924313
128CBP_21632823_ChIP-Seq_H3396_Human0.52857972
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51598542
130LXR_22292898_ChIP-Seq_THP-1_Human0.51533734
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.50123988
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.48787035
133PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48346827
134BCAT_22108803_ChIP-Seq_LS180_Human0.47439431
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.46944730
136P53_21459846_ChIP-Seq_SAOS-2_Human0.46797086
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.45166190
138* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.44797239
139* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42598455
140TP63_23658742_ChIP-Seq_EP156T_Human0.41595864
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.40862251
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40632772
143RACK7_27058665_Chip-Seq_MCF-7_Human0.40553985
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.40396555
145TAF2_19829295_ChIP-Seq_ESCs_Human0.40112809
146SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39622099
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.39012995
148ERG_20517297_ChIP-Seq_VCAP_Human0.38551539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.37378436
2MP0002139_abnormal_hepatobiliary_system8.10615097
3MP0005085_abnormal_gallbladder_physiolo5.99527412
4MP0005365_abnormal_bile_salt5.73657089
5MP0008875_abnormal_xenobiotic_pharmacok5.08659881
6MP0003252_abnormal_bile_duct3.98855959
7MP0003806_abnormal_nucleotide_metabolis3.72735177
8MP0010329_abnormal_lipoprotein_level3.51298493
9MP0009840_abnormal_foam_cell3.47723491
10MP0001666_abnormal_nutrient_absorption3.11709090
11MP0005332_abnormal_amino_acid2.94768942
12MP0003195_calcinosis2.83757268
13MP0005083_abnormal_biliary_tract2.64644680
14MP0004019_abnormal_vitamin_homeostasis2.61593863
15MP0006054_spinal_hemorrhage2.35976018
16MP0003191_abnormal_cellular_cholesterol2.23031149
17MP0002138_abnormal_hepatobiliary_system2.08838370
18MP0000609_abnormal_liver_physiology2.04406395
19MP0002118_abnormal_lipid_homeostasis2.03644449
20MP0005319_abnormal_enzyme/_coenzyme1.70975346
21MP0006082_CNS_inflammation1.68122420
22MP0005451_abnormal_body_composition1.67889723
23MP0009785_altered_susceptibility_to1.66070438
24MP0009643_abnormal_urine_homeostasis1.62425015
25MP0003868_abnormal_feces_composition1.57084901
26MP0001764_abnormal_homeostasis1.53991017
27MP0009697_abnormal_copulation1.53027125
28MP0005584_abnormal_enzyme/coenzyme_acti1.47195272
29MP0003303_peritoneal_inflammation1.45054336
30MP0003183_abnormal_peptide_metabolism1.43074848
31MP0001835_abnormal_antigen_presentation1.41547854
32MP0002148_abnormal_hypersensitivity_rea1.34341241
33MP0002132_abnormal_respiratory_system1.27759521
34MP0010155_abnormal_intestine_physiology1.21170654
35MP0005636_abnormal_mineral_homeostasis1.20348044
36MP0005084_abnormal_gallbladder_morpholo1.15627966
37MP0005025_abnormal_response_to1.15348480
38MP0004043_abnormal_pH_regulation1.13427855
39MP0005387_immune_system_phenotype1.12682778
40MP0001790_abnormal_immune_system1.12682778
41MP0003186_abnormal_redox_activity1.12213254
42MP0003705_abnormal_hypodermis_morpholog1.07913226
43MP0001845_abnormal_inflammatory_respons1.06998559
44MP0000598_abnormal_liver_morphology1.06726698
45MP0003656_abnormal_erythrocyte_physiolo1.05429989
46MP0000604_amyloidosis1.03446621
47MP0002419_abnormal_innate_immunity1.03251653
48MP0000685_abnormal_immune_system1.02397656
49MP0001853_heart_inflammation0.99596968
50MP0005000_abnormal_immune_tolerance0.98755120
51MP0005023_abnormal_wound_healing0.97859989
52MP0008004_abnormal_stomach_pH0.97572321
53MP0003011_delayed_dark_adaptation0.96441949
54MP0009764_decreased_sensitivity_to0.95742745
55MP0001800_abnormal_humoral_immune0.93609187
56MP0002254_reproductive_system_inflammat0.93431594
57MP0001756_abnormal_urination0.92698305
58MP0005408_hypopigmentation0.92284698
59MP0004264_abnormal_extraembryonic_tissu0.92164559
60MP0002876_abnormal_thyroid_physiology0.91399341
61MP0009642_abnormal_blood_homeostasis0.89293801
62MP0005647_abnormal_sex_gland0.84798894
63MP0002078_abnormal_glucose_homeostasis0.83943518
64MP0002452_abnormal_antigen_presenting0.83335316
65MP0009763_increased_sensitivity_to0.83278371
66MP0006036_abnormal_mitochondrial_physio0.80165633
67MP0008469_abnormal_protein_level0.78778311
68MP0002136_abnormal_kidney_physiology0.78624927
69MP0001533_abnormal_skeleton_physiology0.74601255
70MP0004947_skin_inflammation0.73952176
71MP0005376_homeostasis/metabolism_phenot0.73769005
72MP0002723_abnormal_immune_serum0.73609862
73MP0010368_abnormal_lymphatic_system0.73147368
74MP0003718_maternal_effect0.73062671
75MP0005164_abnormal_response_to0.73042292
76MP0009765_abnormal_xenobiotic_induced0.72786448
77MP0001545_abnormal_hematopoietic_system0.71962196
78MP0005397_hematopoietic_system_phenotyp0.71962196
79MP0010234_abnormal_vibrissa_follicle0.71594791
80MP0005220_abnormal_exocrine_pancreas0.71054511
81MP0002971_abnormal_brown_adipose0.70314729
82MP0005310_abnormal_salivary_gland0.69291469
83MP0005448_abnormal_energy_balance0.67964183
84MP0002295_abnormal_pulmonary_circulatio0.65671997
85MP0005334_abnormal_fat_pad0.64798748
86MP0003941_abnormal_skin_development0.64587431
87MP0005535_abnormal_body_temperature0.64579836
88MP0003329_amyloid_beta_deposits0.64560759
89MP0009333_abnormal_splenocyte_physiolog0.64322538
90MP0001765_abnormal_ion_homeostasis0.63257927
91MP0005395_other_phenotype0.62985767
92MP0005266_abnormal_metabolism0.62111130
93MP0001661_extended_life_span0.61864908
94MP0005671_abnormal_response_to0.60133654
95MP0009053_abnormal_anal_canal0.59109359
96MP0005670_abnormal_white_adipose0.58354818
97MP0002822_catalepsy0.58120319
98MP0003172_abnormal_lysosome_physiology0.57005190
99MP0001915_intracranial_hemorrhage0.55399643
100MP0000538_abnormal_urinary_bladder0.55223634
101MP0010352_gastrointestinal_tract_polyps0.55014935
102MP0002405_respiratory_system_inflammati0.53028622
103MP0000343_altered_response_to0.52914631
104MP0008438_abnormal_cutaneous_collagen0.52163765
105MP0003448_altered_tumor_morphology0.51883145
106MP0004782_abnormal_surfactant_physiolog0.51581691
107MP0002928_abnormal_bile_duct0.51046210
108MP0000639_abnormal_adrenal_gland0.50935075
109MP0003638_abnormal_response/metabolism_0.50631398
110MP0003953_abnormal_hormone_level0.49118326
111MP0003300_gastrointestinal_ulcer0.48862461
112MP0004130_abnormal_muscle_cell0.48165093
113MP0003690_abnormal_glial_cell0.46390270
114MP0005464_abnormal_platelet_physiology0.45318325
115MP0006035_abnormal_mitochondrial_morpho0.44258064
116MP0000230_abnormal_systemic_arterial0.43611650
117MP0005666_abnormal_adipose_tissue0.40435461
118MP0002168_other_aberrant_phenotype0.39561526
119MP0002796_impaired_skin_barrier0.39511710
120MP0008872_abnormal_physiological_respon0.39127741
121MP0008873_increased_physiological_sensi0.39019656
122MP0009115_abnormal_fat_cell0.36312021
123MP0003724_increased_susceptibility_to0.35908479
124MP0008874_decreased_physiological_sensi0.35773863
125MP0005167_abnormal_blood-brain_barrier0.34853849
126MP0005058_abnormal_lysosome_morphology0.33936134
127MP0009672_abnormal_birth_weight0.33292189
128MP0005166_decreased_susceptibility_to0.31336450
129MP0002135_abnormal_kidney_morphology0.31328755
130MP0005248_abnormal_Harderian_gland0.30710003
131MP0002837_dystrophic_cardiac_calcinosis0.30708403
132MP0003075_altered_response_to0.30069376
133MP0004147_increased_porphyrin_level0.30042845
134MP0000249_abnormal_blood_vessel0.28955394
135MP0000579_abnormal_nail_morphology0.28601464
136MP0001944_abnormal_pancreas_morphology0.27810403
137MP0000462_abnormal_digestive_system0.27122457
138MP0003436_decreased_susceptibility_to0.26703400
139MP0001881_abnormal_mammary_gland0.26606338

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.84642238
2Intrahepatic cholestasis (HP:0001406)6.64598886
3Hypobetalipoproteinemia (HP:0003563)6.64198823
4Deep venous thrombosis (HP:0002625)6.48498271
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.21719184
6Xanthomatosis (HP:0000991)5.98072725
7Prolonged partial thromboplastin time (HP:0003645)5.54415159
8Abnormality of glutamine family amino acid metabolism (HP:0010902)5.14112131
9Hypolipoproteinemia (HP:0010981)4.77201457
10Hyperlipoproteinemia (HP:0010980)4.73864100
11Hyperglycinuria (HP:0003108)4.66897445
12Hyperammonemia (HP:0001987)4.54836049
13Abnormality of glycine metabolism (HP:0010895)4.36117627
14Abnormality of serine family amino acid metabolism (HP:0010894)4.36117627
15Ketosis (HP:0001946)4.33892788
16Hyperglycinemia (HP:0002154)4.28916616
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.26434140
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26233776
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.19345335
20Joint hemorrhage (HP:0005261)4.15561704
21Conjugated hyperbilirubinemia (HP:0002908)4.13648600
22Fat malabsorption (HP:0002630)4.13017106
23Epidermoid cyst (HP:0200040)4.12359233
24Hypoglycemic coma (HP:0001325)4.11025022
25Recurrent gram-negative bacterial infections (HP:0005420)4.05888861
26Abnormality of the common coagulation pathway (HP:0010990)3.98639670
27Complement deficiency (HP:0004431)3.85722061
28Hypoalphalipoproteinemia (HP:0003233)3.81187388
29Abnormality of methionine metabolism (HP:0010901)3.64167655
30Hypercholesterolemia (HP:0003124)3.61878327
31Abnormality of glycolipid metabolism (HP:0010969)3.56384702
32Abnormality of liposaccharide metabolism (HP:0010968)3.56384702
33Abnormality of glycosphingolipid metabolism (HP:0004343)3.56384702
34Ketoacidosis (HP:0001993)3.54860659
35Vacuolated lymphocytes (HP:0001922)3.45464683
36Abnormality of pyrimidine metabolism (HP:0004353)3.45440762
37Abnormality of fatty-acid metabolism (HP:0004359)3.44566917
38Abnormality of nucleobase metabolism (HP:0010932)3.40484797
39Abnormality of purine metabolism (HP:0004352)3.38006814
40Abnormality of the intrinsic pathway (HP:0010989)3.35738148
41Hyperbilirubinemia (HP:0002904)3.31055759
42Gout (HP:0001997)3.27327351
43Acanthocytosis (HP:0001927)3.24700613
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.20871842
45Malnutrition (HP:0004395)3.09586613
46Delayed CNS myelination (HP:0002188)3.05398522
47Nausea (HP:0002018)3.04390150
48Metabolic acidosis (HP:0001942)3.03345706
49Nephritis (HP:0000123)2.90712715
50Abnormality of serum amino acid levels (HP:0003112)2.87630827
51Hepatocellular carcinoma (HP:0001402)2.81910472
52Vascular calcification (HP:0004934)2.77926420
53Hypoglycemic seizures (HP:0002173)2.77681543
54Abnormality of complement system (HP:0005339)2.74274417
55Abnormality of proline metabolism (HP:0010907)2.72928499
56Hydroxyprolinuria (HP:0003080)2.72928499
57Steatorrhea (HP:0002570)2.69545364
58Dicarboxylic aciduria (HP:0003215)2.69538196
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69538196
60Proximal tubulopathy (HP:0000114)2.60812175
61Lethargy (HP:0001254)2.60812035
62Generalized aminoaciduria (HP:0002909)2.58603320
63Spontaneous abortion (HP:0005268)2.55773625
64Skin nodule (HP:0200036)2.54271107
65Glycosuria (HP:0003076)2.53348585
66Abnormality of urine glucose concentration (HP:0011016)2.53348585
67Myocardial infarction (HP:0001658)2.52043262
68Alkalosis (HP:0001948)2.47730987
69Late onset (HP:0003584)2.46988549
70Cardiovascular calcification (HP:0011915)2.46412351
71Irritability (HP:0000737)2.42571345
72Purpura (HP:0000979)2.41521058
73Hyperuricemia (HP:0002149)2.38685955
74Increased purine levels (HP:0004368)2.38685955
75Reduced antithrombin III activity (HP:0001976)2.35216319
76Gingival bleeding (HP:0000225)2.32983881
77Hypochromic microcytic anemia (HP:0004840)2.32473212
78Poikilocytosis (HP:0004447)2.31489480
79Autoimmune hemolytic anemia (HP:0001890)2.30172143
80Abnormal gallbladder physiology (HP:0012438)2.27927463
81Cholecystitis (HP:0001082)2.27927463
82Spastic diplegia (HP:0001264)2.27911630
83Abnormal gallbladder morphology (HP:0012437)2.27811638
84Hyperinsulinemic hypoglycemia (HP:0000825)2.27622766
85Pancreatitis (HP:0001733)2.23121445
86Abnormality of the vasculature of the conjunctiva (HP:0008054)2.21090763
87Cholelithiasis (HP:0001081)2.20800412
88Vomiting (HP:0002013)2.20266394
89Rickets (HP:0002748)2.19909906
90Esophageal varix (HP:0002040)2.18605103
91Glomerulonephritis (HP:0000099)2.18257816
92Beaking of vertebral bodies (HP:0004568)2.17751905
93Enlarged kidneys (HP:0000105)2.15576727
94Dysostosis multiplex (HP:0000943)2.11922838
95Amyloidosis (HP:0011034)2.11665097
96Systemic lupus erythematosus (HP:0002725)2.11615243
97Cerebral edema (HP:0002181)2.11545918
98Increased serum ferritin (HP:0003281)2.11529652
99Elevated alkaline phosphatase (HP:0003155)2.11022666
100Sensorimotor neuropathy (HP:0007141)2.10799230
101Neonatal onset (HP:0003623)2.08480531
102Joint swelling (HP:0001386)2.07690381
103Mitral stenosis (HP:0001718)2.07440619
104Confusion (HP:0001289)2.07430755
105Symptomatic seizures (HP:0011145)2.05610822
106Thrombophlebitis (HP:0004418)2.02808725
107Abnormality of iron homeostasis (HP:0011031)2.02056349
108Abnormality of alkaline phosphatase activity (HP:0004379)2.01208386
109Abnormality of vitamin metabolism (HP:0100508)2.00822809
110Recurrent abscess formation (HP:0002722)1.99296651
111Brushfield spots (HP:0001088)1.98394868
112Nephrolithiasis (HP:0000787)1.98163494
113Autoimmune thrombocytopenia (HP:0001973)1.96414289
114Abnormality of macrophages (HP:0004311)1.95242184
115Abnormal biliary tract physiology (HP:0012439)1.94694401
116Bile duct proliferation (HP:0001408)1.94694401
117Abnormal enzyme/coenzyme activity (HP:0012379)1.93948124
118Petechiae (HP:0000967)1.93597575
119Conjunctival telangiectasia (HP:0000524)1.91299575
120Menorrhagia (HP:0000132)1.90701447
121Disinhibition (HP:0000734)1.90642963
122Pulmonary embolism (HP:0002204)1.89380752
123Hypophosphatemic rickets (HP:0004912)1.88498578
124Abnormal cartilage morphology (HP:0002763)1.88046914
125Abnormality of transition element cation homeostasis (HP:0011030)1.87130126
126Cerebral palsy (HP:0100021)1.86319131
127Abnormality of the gallbladder (HP:0005264)1.85642631
128Hyperglycemia (HP:0003074)1.85615999
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85602833
130Abnormality of polysaccharide metabolism (HP:0011012)1.85602833
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85602833
132Ileus (HP:0002595)1.85056781
133Hemorrhage of the eye (HP:0011885)1.84265508
134Urinary glycosaminoglycan excretion (HP:0003541)1.84057803
135Mucopolysacchariduria (HP:0008155)1.84057803
136Hypophosphatemia (HP:0002148)1.82715501
137Gangrene (HP:0100758)1.77991938
138Recurrent bacterial skin infections (HP:0005406)1.74609732
139Increased cerebral lipofuscin (HP:0011813)1.71375330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.16892771
2FGFR43.93258387
3ERN13.84515739
4TRIM283.81870074
5SIK13.71695283
6FRK3.45688062
7TAOK33.33672803
8ACVR1B3.19766386
9INSRR2.99680352
10MST1R2.92800137
11ERBB42.42066280
12GRK72.41779613
13SIK32.41246262
14LATS12.32315219
15BCR2.17551141
16EIF2AK32.06302141
17WNK42.00039501
18PKN21.91622316
19PDK21.81786042
20MAP2K41.80123789
21WNK31.71089717
22PTK61.70732030
23MYLK1.66027600
24PIK3CG1.62911118
25MAP4K11.61084571
26STK241.60525808
27MAPK111.58944046
28GRK61.58736652
29DDR21.56079054
30FLT31.55815567
31STK38L1.53317413
32PRKAA21.46748382
33TYK21.44479318
34STK161.42997752
35BLK1.41704314
36BUB11.41200801
37TRIB31.39494372
38MUSK1.37174885
39OXSR11.36392400
40BMPR21.32992953
41NME21.29858611
42IKBKE1.27572599
43ABL21.23413701
44MAP3K121.20974027
45DAPK21.17689084
46RIPK11.17487281
47TEC1.17025689
48MET1.15687597
49STK101.15480656
50MAP3K101.13244754
51NEK91.12640978
52FGFR21.12467635
53MAP3K71.10889719
54BRSK21.03968045
55PINK11.01352737
56JAK20.99411128
57MAPKAPK30.99208349
58PRKAA10.97687568
59PLK40.95050256
60KDR0.91557514
61PTK20.89558104
62JAK30.88870635
63KIT0.88154467
64EPHB10.87966978
65SGK30.86765598
66MAP3K30.86537159
67ERBB20.84758618
68MELK0.83552810
69CSF1R0.82362093
70TAOK20.81668114
71PRPF4B0.81494233
72IKBKB0.81223894
73WEE10.80401196
74PRKCZ0.80133783
75MAP3K60.79171509
76AKT30.78525090
77MAP3K110.77572075
78GSK3A0.77570618
79TAF10.77262511
80TNK20.77102690
81MATK0.77050607
82TBK10.75930334
83MOS0.75851738
84EIF2AK20.75325189
85PRKG20.72707600
86IRAK40.72635913
87MARK30.72452744
88PRKACG0.72124081
89SGK2230.71879876
90SGK4940.71879876
91JAK10.71859988
92SGK20.71061115
93KSR20.71003614
94MAP2K30.70587378
95MAP3K20.68838579
96DYRK1B0.67407190
97CDK60.65766172
98MAP2K20.64639253
99TIE10.63847355
100TRPM70.63810734
101NLK0.63800492
102LRRK20.63653616
103MAPK40.63194343
104CAMK1D0.62835437
105CSK0.62140279
106MAPK150.60814341
107TXK0.60466390
108PDK30.60196935
109PDK40.60196935
110MAPKAPK20.60113641
111PDPK10.59741037
112ZAP700.58758715
113CDC42BPA0.57960872
114MAP2K60.57573672
115MAP3K140.57321220
116LYN0.56767273
117TESK10.56704479
118MAP2K10.56565063
119LMTK20.56396874
120TESK20.54122850
121EPHA30.54085291
122NUAK10.51304549
123SMG10.51087878
124IRAK30.50844459
125MAP3K10.49566058
126FGR0.49090287
127GRK10.47832911
128YES10.47796524
129MAP3K130.47631059
130FGFR30.47622074
131PAK40.46473004
132CAMK2G0.46206431
133STK30.44484150
134KSR10.43725912
135PAK30.42841157
136PBK0.42745870
137BTK0.42477504
138DYRK30.42196422
139VRK20.41966964
140CSNK1G10.41202720
141CDK90.41094563
142RET0.40223728
143MAPK120.39960605
144ABL10.39789062
145PRKCQ0.39717682
146ITK0.39423569
147TGFBR20.38278757
148PIK3CA0.37748851
149EPHA20.35211033
150TAOK10.35094544
151IGF1R0.34957554
152MAP3K50.34580768
153FER0.33877989
154PRKCD0.33085923
155LATS20.32995861
156NEK10.32691430
157STK390.32207269
158EPHB20.32036255
159PDK10.31774755
160MTOR0.30138201
161PRKCA0.29167913
162MST40.28334740

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.79516131
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.57603422
3Nitrogen metabolism_Homo sapiens_hsa009103.35141950
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96575033
5Arginine biosynthesis_Homo sapiens_hsa002202.87658375
6Tryptophan metabolism_Homo sapiens_hsa003802.70083501
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68831613
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58737227
9Fatty acid degradation_Homo sapiens_hsa000712.55109640
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44877892
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40225187
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31892388
13Butanoate metabolism_Homo sapiens_hsa006502.28275659
14Complement and coagulation cascades_Homo sapiens_hsa046102.24512819
15Peroxisome_Homo sapiens_hsa041462.04974323
16* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04624237
17Propanoate metabolism_Homo sapiens_hsa006402.03784458
18Histidine metabolism_Homo sapiens_hsa003402.02816579
19PPAR signaling pathway_Homo sapiens_hsa033201.92046545
20Chemical carcinogenesis_Homo sapiens_hsa052041.86520396
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85979173
22Fatty acid metabolism_Homo sapiens_hsa012121.85784468
23beta-Alanine metabolism_Homo sapiens_hsa004101.79033932
24Fat digestion and absorption_Homo sapiens_hsa049751.77623475
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75657431
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.73256769
27Caffeine metabolism_Homo sapiens_hsa002321.71906409
28Bile secretion_Homo sapiens_hsa049761.68576303
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68182001
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.66698458
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60810011
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59869725
33Retinol metabolism_Homo sapiens_hsa008301.58686142
34Sulfur metabolism_Homo sapiens_hsa009201.57490432
35Starch and sucrose metabolism_Homo sapiens_hsa005001.53653044
36Pyruvate metabolism_Homo sapiens_hsa006201.52473482
37Vitamin digestion and absorption_Homo sapiens_hsa049771.48727379
38Selenocompound metabolism_Homo sapiens_hsa004501.48364916
39Phenylalanine metabolism_Homo sapiens_hsa003601.43088592
40Staphylococcus aureus infection_Homo sapiens_hsa051501.41192376
41Folate biosynthesis_Homo sapiens_hsa007901.40443414
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.39776323
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.31673303
44Fatty acid elongation_Homo sapiens_hsa000621.24913335
45ABC transporters_Homo sapiens_hsa020101.23539475
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21883833
47Tyrosine metabolism_Homo sapiens_hsa003501.21868065
48Carbon metabolism_Homo sapiens_hsa012001.19312641
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18267601
50Steroid biosynthesis_Homo sapiens_hsa001001.17981711
51Biosynthesis of amino acids_Homo sapiens_hsa012301.13392686
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.13177426
53Arginine and proline metabolism_Homo sapiens_hsa003301.11581847
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02295731
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95363319
56Lysine degradation_Homo sapiens_hsa003100.91816786
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88701114
58Glycerolipid metabolism_Homo sapiens_hsa005610.87337287
59Glutathione metabolism_Homo sapiens_hsa004800.85377980
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84513289
61Allograft rejection_Homo sapiens_hsa053300.83817214
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83128712
63Asthma_Homo sapiens_hsa053100.80592721
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77205920
65Sulfur relay system_Homo sapiens_hsa041220.76880004
66Lysosome_Homo sapiens_hsa041420.68788100
67Vitamin B6 metabolism_Homo sapiens_hsa007500.66622661
68Graft-versus-host disease_Homo sapiens_hsa053320.66126129
69Autoimmune thyroid disease_Homo sapiens_hsa053200.66097401
70Pertussis_Homo sapiens_hsa051330.65476338
71Galactose metabolism_Homo sapiens_hsa000520.58560318
72Pentose phosphate pathway_Homo sapiens_hsa000300.58413776
73Sphingolipid metabolism_Homo sapiens_hsa006000.58010732
74Fatty acid biosynthesis_Homo sapiens_hsa000610.55657016
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.55394091
76One carbon pool by folate_Homo sapiens_hsa006700.53586282
77Fructose and mannose metabolism_Homo sapiens_hsa000510.46938365
78Metabolic pathways_Homo sapiens_hsa011000.46859232
79Renin-angiotensin system_Homo sapiens_hsa046140.45960820
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40807456
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40465122
82Mineral absorption_Homo sapiens_hsa049780.33209420
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32248846
84Leishmaniasis_Homo sapiens_hsa051400.31888651
85Type I diabetes mellitus_Homo sapiens_hsa049400.31169733
86Linoleic acid metabolism_Homo sapiens_hsa005910.27705786
87Rheumatoid arthritis_Homo sapiens_hsa053230.26757859
88Insulin resistance_Homo sapiens_hsa049310.24671422
89Antigen processing and presentation_Homo sapiens_hsa046120.23116521
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.22576619
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20438871
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.18631920
93Osteoclast differentiation_Homo sapiens_hsa043800.17753496
94Malaria_Homo sapiens_hsa051440.16663854
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15745551
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.13843038
97Tuberculosis_Homo sapiens_hsa051520.12979459
98Protein digestion and absorption_Homo sapiens_hsa049740.12702370
99Influenza A_Homo sapiens_hsa051640.12196304
100Herpes simplex infection_Homo sapiens_hsa051680.10884757
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.09283623
102Glucagon signaling pathway_Homo sapiens_hsa049220.08399293
103Systemic lupus erythematosus_Homo sapiens_hsa053220.07272743
104Hematopoietic cell lineage_Homo sapiens_hsa046400.06931474
105TNF signaling pathway_Homo sapiens_hsa046680.05879205
106Legionellosis_Homo sapiens_hsa051340.05119701
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03814984
108AMPK signaling pathway_Homo sapiens_hsa041520.03785111
109Prion diseases_Homo sapiens_hsa050200.01061233
110Circadian rhythm_Homo sapiens_hsa04710-0.2285167
111Regulation of autophagy_Homo sapiens_hsa04140-0.2116297
112Other glycan degradation_Homo sapiens_hsa00511-0.2028047
113African trypanosomiasis_Homo sapiens_hsa05143-0.1889124
114Bladder cancer_Homo sapiens_hsa05219-0.1829914
115Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1688222
116Type II diabetes mellitus_Homo sapiens_hsa04930-0.1647889
117Ether lipid metabolism_Homo sapiens_hsa00565-0.1613742
118Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1610660
119Hepatitis C_Homo sapiens_hsa05160-0.1593282
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1532958
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1072298
122Insulin signaling pathway_Homo sapiens_hsa04910-0.1051076
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0723875
124Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0330366
125Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0022733

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